-- dump date   	20140620_074746
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1194085000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1194085000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1194085000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085000004	Walker A motif; other site
1194085000005	ATP binding site [chemical binding]; other site
1194085000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1194085000007	Walker B motif; other site
1194085000008	arginine finger; other site
1194085000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1194085000010	DnaA box-binding interface [nucleotide binding]; other site
1194085000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
1194085000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1194085000013	putative DNA binding surface [nucleotide binding]; other site
1194085000014	dimer interface [polypeptide binding]; other site
1194085000015	beta-clamp/clamp loader binding surface; other site
1194085000016	beta-clamp/translesion DNA polymerase binding surface; other site
1194085000017	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1194085000018	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1194085000019	recF protein; Region: recf; TIGR00611
1194085000020	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1194085000021	Walker A/P-loop; other site
1194085000022	ATP binding site [chemical binding]; other site
1194085000023	Q-loop/lid; other site
1194085000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085000025	ABC transporter signature motif; other site
1194085000026	Walker B; other site
1194085000027	D-loop; other site
1194085000028	H-loop/switch region; other site
1194085000029	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1194085000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085000031	Mg2+ binding site [ion binding]; other site
1194085000032	G-X-G motif; other site
1194085000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1194085000034	anchoring element; other site
1194085000035	dimer interface [polypeptide binding]; other site
1194085000036	ATP binding site [chemical binding]; other site
1194085000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1194085000038	active site
1194085000039	putative metal-binding site [ion binding]; other site
1194085000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1194085000041	DNA gyrase subunit A; Validated; Region: PRK05560
1194085000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1194085000043	CAP-like domain; other site
1194085000044	active site
1194085000045	primary dimer interface [polypeptide binding]; other site
1194085000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1194085000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1194085000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1194085000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1194085000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1194085000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1194085000052	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1194085000053	putative substrate binding site [chemical binding]; other site
1194085000054	putative ATP binding site [chemical binding]; other site
1194085000055	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1194085000056	active sites [active]
1194085000057	tetramer interface [polypeptide binding]; other site
1194085000058	seryl-tRNA synthetase; Provisional; Region: PRK05431
1194085000059	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1194085000060	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1194085000061	dimer interface [polypeptide binding]; other site
1194085000062	active site
1194085000063	motif 1; other site
1194085000064	motif 2; other site
1194085000065	motif 3; other site
1194085000066	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1194085000067	Predicted membrane protein [Function unknown]; Region: COG4392
1194085000068	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1194085000069	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1194085000070	Predicted membrane protein [Function unknown]; Region: COG4241
1194085000071	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1194085000072	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1194085000073	DHH family; Region: DHH; pfam01368
1194085000074	DHHA1 domain; Region: DHHA1; pfam02272
1194085000075	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1194085000076	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1194085000077	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1194085000078	replicative DNA helicase; Region: DnaB; TIGR00665
1194085000079	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1194085000080	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1194085000081	Walker A motif; other site
1194085000082	ATP binding site [chemical binding]; other site
1194085000083	Walker B motif; other site
1194085000084	DNA binding loops [nucleotide binding]
1194085000085	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1194085000086	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1194085000087	GDP-binding site [chemical binding]; other site
1194085000088	ACT binding site; other site
1194085000089	IMP binding site; other site
1194085000090	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1194085000091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085000092	active site
1194085000093	phosphorylation site [posttranslational modification]
1194085000094	intermolecular recognition site; other site
1194085000095	dimerization interface [polypeptide binding]; other site
1194085000096	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1194085000097	DNA binding site [nucleotide binding]
1194085000098	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1194085000099	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1194085000100	dimerization interface [polypeptide binding]; other site
1194085000101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1194085000102	putative active site [active]
1194085000103	heme pocket [chemical binding]; other site
1194085000104	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1194085000105	dimer interface [polypeptide binding]; other site
1194085000106	phosphorylation site [posttranslational modification]
1194085000107	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085000108	ATP binding site [chemical binding]; other site
1194085000109	Mg2+ binding site [ion binding]; other site
1194085000110	G-X-G motif; other site
1194085000111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1194085000112	YycH protein; Region: YycH; pfam07435
1194085000113	YycH protein; Region: YycI; cl02015
1194085000114	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1194085000115	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1194085000116	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
1194085000117	putative active site [active]
1194085000118	putative metal binding site [ion binding]; other site
1194085000119	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1194085000120	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1194085000121	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1194085000122	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
1194085000123	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
1194085000124	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
1194085000125	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1194085000126	Integrase core domain; Region: rve; pfam00665
1194085000127	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
1194085000128	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1194085000129	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1194085000130	putative active site [active]
1194085000131	catalytic site [active]
1194085000132	putative metal binding site [ion binding]; other site
1194085000133	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1194085000134	putative active site [active]
1194085000135	putative catalytic site [active]
1194085000136	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1194085000137	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1194085000138	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1194085000139	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1194085000140	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1194085000141	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
1194085000142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085000143	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085000144	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1194085000145	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1194085000146	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
1194085000147	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
1194085000148	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1194085000149	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1194085000150	catalytic residues [active]
1194085000151	catalytic nucleophile [active]
1194085000152	Presynaptic Site I dimer interface [polypeptide binding]; other site
1194085000153	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1194085000154	Synaptic Flat tetramer interface [polypeptide binding]; other site
1194085000155	Synaptic Site I dimer interface [polypeptide binding]; other site
1194085000156	DNA binding site [nucleotide binding]
1194085000157	Recombinase; Region: Recombinase; pfam07508
1194085000158	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1194085000159	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1194085000160	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1194085000161	catalytic residues [active]
1194085000162	catalytic nucleophile [active]
1194085000163	Recombinase; Region: Recombinase; pfam07508
1194085000164	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1194085000165	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
1194085000166	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
1194085000167	Homeodomain-like domain; Region: HTH_23; cl17451
1194085000168	putative transposase OrfB; Reviewed; Region: PHA02517
1194085000169	HTH-like domain; Region: HTH_21; pfam13276
1194085000170	Integrase core domain; Region: rve; pfam00665
1194085000171	Integrase core domain; Region: rve_3; pfam13683
1194085000172	SIR2-like domain; Region: SIR2_2; pfam13289
1194085000173	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1194085000174	Domain of unknown function DUF87; Region: DUF87; pfam01935
1194085000175	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1194085000176	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1194085000177	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1194085000178	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1194085000179	putative DNA binding site [nucleotide binding]; other site
1194085000180	putative Zn2+ binding site [ion binding]; other site
1194085000181	AsnC family; Region: AsnC_trans_reg; pfam01037
1194085000182	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085000183	Coenzyme A binding pocket [chemical binding]; other site
1194085000184	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1194085000185	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1194085000186	FMN binding site [chemical binding]; other site
1194085000187	active site
1194085000188	catalytic residues [active]
1194085000189	substrate binding site [chemical binding]; other site
1194085000190	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
1194085000191	H+ Antiporter protein; Region: 2A0121; TIGR00900
1194085000192	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085000193	putative substrate translocation pore; other site
1194085000194	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1194085000195	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1194085000196	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1194085000197	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1194085000198	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1194085000199	Winged helix-turn helix; Region: HTH_29; pfam13551
1194085000200	Integrase core domain; Region: rve; pfam00665
1194085000201	transposase/IS protein; Provisional; Region: PRK09183
1194085000202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085000203	Walker A motif; other site
1194085000204	ATP binding site [chemical binding]; other site
1194085000205	Walker B motif; other site
1194085000206	arginine finger; other site
1194085000207	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1194085000208	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1194085000209	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1194085000210	Part of AAA domain; Region: AAA_19; pfam13245
1194085000211	AAA domain; Region: AAA_12; pfam13087
1194085000212	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1194085000213	active site
1194085000214	catalytic site [active]
1194085000215	putative metal binding site [ion binding]; other site
1194085000216	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085000217	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1194085000218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1194085000219	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1194085000220	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1194085000221	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1194085000222	metal binding site [ion binding]; metal-binding site
1194085000223	dimer interface [polypeptide binding]; other site
1194085000224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085000225	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085000226	putative substrate translocation pore; other site
1194085000227	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085000228	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1194085000229	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1194085000230	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1194085000231	PhoU domain; Region: PhoU; pfam01895
1194085000232	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
1194085000233	EamA-like transporter family; Region: EamA; pfam00892
1194085000234	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1194085000235	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1194085000236	DNA-binding site [nucleotide binding]; DNA binding site
1194085000237	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1194085000238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085000239	homodimer interface [polypeptide binding]; other site
1194085000240	catalytic residue [active]
1194085000241	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1194085000242	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1194085000243	L-lactate permease; Region: Lactate_perm; cl00701
1194085000244	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1194085000245	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1194085000246	B domain; Region: B; pfam02216
1194085000247	B domain; Region: B; pfam02216
1194085000248	B domain; Region: B; pfam02216
1194085000249	B domain; Region: B; pfam02216
1194085000250	B domain; Region: B; pfam02216
1194085000251	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1194085000252	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085000253	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1194085000254	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085000255	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1194085000256	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1194085000257	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085000258	ABC-ATPase subunit  interface; other site
1194085000259	dimer interface [polypeptide binding]; other site
1194085000260	putative PBP binding regions; other site
1194085000261	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1194085000262	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085000263	ABC-ATPase subunit  interface; other site
1194085000264	dimer interface [polypeptide binding]; other site
1194085000265	putative PBP binding regions; other site
1194085000266	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1194085000267	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1194085000268	siderophore binding site; other site
1194085000269	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
1194085000270	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1194085000271	dimer interface [polypeptide binding]; other site
1194085000272	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085000273	catalytic residue [active]
1194085000274	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
1194085000275	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1194085000276	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1194085000277	IucA / IucC family; Region: IucA_IucC; pfam04183
1194085000278	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1194085000279	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085000280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085000281	putative substrate translocation pore; other site
1194085000282	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1194085000283	IucA / IucC family; Region: IucA_IucC; pfam04183
1194085000284	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1194085000285	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1194085000286	IucA / IucC family; Region: IucA_IucC; pfam04183
1194085000287	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1194085000288	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1194085000289	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1194085000290	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
1194085000291	dimer interface [polypeptide binding]; other site
1194085000292	active site
1194085000293	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1194085000294	catalytic residues [active]
1194085000295	substrate binding site [chemical binding]; other site
1194085000296	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1194085000297	ParB-like nuclease domain; Region: ParBc; pfam02195
1194085000298	acetoin reductase; Validated; Region: PRK08643
1194085000299	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1194085000300	NAD binding site [chemical binding]; other site
1194085000301	homotetramer interface [polypeptide binding]; other site
1194085000302	homodimer interface [polypeptide binding]; other site
1194085000303	active site
1194085000304	substrate binding site [chemical binding]; other site
1194085000305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1194085000306	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1194085000307	NAD(P) binding site [chemical binding]; other site
1194085000308	active site
1194085000309	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1194085000310	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1194085000311	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1194085000312	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1194085000313	putative ADP-binding pocket [chemical binding]; other site
1194085000314	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1194085000315	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1194085000316	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1194085000317	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1194085000318	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1194085000319	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085000320	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085000321	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1194085000322	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085000323	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1194085000324	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1194085000325	DNA-binding site [nucleotide binding]; DNA binding site
1194085000326	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1194085000327	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1194085000328	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085000329	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1194085000330	intersubunit interface [polypeptide binding]; other site
1194085000331	active site
1194085000332	catalytic residue [active]
1194085000333	phosphopentomutase; Provisional; Region: PRK05362
1194085000334	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1194085000335	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1194085000336	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085000337	dimer interface [polypeptide binding]; other site
1194085000338	conserved gate region; other site
1194085000339	putative PBP binding loops; other site
1194085000340	ABC-ATPase subunit interface; other site
1194085000341	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1194085000342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085000343	dimer interface [polypeptide binding]; other site
1194085000344	conserved gate region; other site
1194085000345	ABC-ATPase subunit interface; other site
1194085000346	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1194085000347	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1194085000348	Walker A/P-loop; other site
1194085000349	ATP binding site [chemical binding]; other site
1194085000350	Q-loop/lid; other site
1194085000351	ABC transporter signature motif; other site
1194085000352	Walker B; other site
1194085000353	D-loop; other site
1194085000354	H-loop/switch region; other site
1194085000355	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1194085000356	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1194085000357	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1194085000358	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1194085000359	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1194085000360	active site
1194085000361	metal binding site [ion binding]; metal-binding site
1194085000362	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1194085000363	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1194085000364	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1194085000365	non-specific DNA binding site [nucleotide binding]; other site
1194085000366	salt bridge; other site
1194085000367	sequence-specific DNA binding site [nucleotide binding]; other site
1194085000368	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1194085000369	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1194085000370	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1194085000371	putative catalytic cysteine [active]
1194085000372	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1194085000373	putative active site [active]
1194085000374	metal binding site [ion binding]; metal-binding site
1194085000375	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1194085000376	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
1194085000377	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1194085000378	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1194085000379	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1194085000380	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1194085000381	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
1194085000382	NAD(P) binding site [chemical binding]; other site
1194085000383	homodimer interface [polypeptide binding]; other site
1194085000384	substrate binding site [chemical binding]; other site
1194085000385	active site
1194085000386	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
1194085000387	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1194085000388	NAD(P) binding site [chemical binding]; other site
1194085000389	homodimer interface [polypeptide binding]; other site
1194085000390	substrate binding site [chemical binding]; other site
1194085000391	active site
1194085000392	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
1194085000393	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
1194085000394	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1194085000395	putative NAD(P) binding site [chemical binding]; other site
1194085000396	active site
1194085000397	putative substrate binding site [chemical binding]; other site
1194085000398	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1194085000399	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1194085000400	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1194085000401	active site
1194085000402	homodimer interface [polypeptide binding]; other site
1194085000403	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1194085000404	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1194085000405	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1194085000406	trimer interface [polypeptide binding]; other site
1194085000407	active site
1194085000408	substrate binding site [chemical binding]; other site
1194085000409	CoA binding site [chemical binding]; other site
1194085000410	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1194085000411	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1194085000412	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1194085000413	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1194085000414	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
1194085000415	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1194085000416	putative NAD(P) binding site [chemical binding]; other site
1194085000417	active site
1194085000418	putative substrate binding site [chemical binding]; other site
1194085000419	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1194085000420	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1194085000421	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1194085000422	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1194085000423	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1194085000424	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1194085000425	active site
1194085000426	homodimer interface [polypeptide binding]; other site
1194085000427	heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313
1194085000428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1194085000429	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
1194085000430	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1194085000431	NAD(P) binding site [chemical binding]; other site
1194085000432	catalytic residues [active]
1194085000433	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1194085000434	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1194085000435	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
1194085000436	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1194085000437	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1194085000438	Walker A/P-loop; other site
1194085000439	ATP binding site [chemical binding]; other site
1194085000440	Q-loop/lid; other site
1194085000441	ABC transporter signature motif; other site
1194085000442	Walker B; other site
1194085000443	D-loop; other site
1194085000444	H-loop/switch region; other site
1194085000445	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1194085000446	NMT1-like family; Region: NMT1_2; pfam13379
1194085000447	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1194085000448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1194085000449	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1194085000450	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1194085000451	active site
1194085000452	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085000453	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1194085000454	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1194085000455	acyl-activating enzyme (AAE) consensus motif; other site
1194085000456	AMP binding site [chemical binding]; other site
1194085000457	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1194085000458	Condensation domain; Region: Condensation; pfam00668
1194085000459	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1194085000460	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1194085000461	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1194085000462	acyl-activating enzyme (AAE) consensus motif; other site
1194085000463	AMP binding site [chemical binding]; other site
1194085000464	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1194085000465	thioester reductase domain; Region: Thioester-redct; TIGR01746
1194085000466	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1194085000467	NAD(P) binding site [chemical binding]; other site
1194085000468	active site
1194085000469	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1194085000470	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1194085000471	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
1194085000472	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1194085000473	nucleotide binding site [chemical binding]; other site
1194085000474	N-acetyl-L-glutamate binding site [chemical binding]; other site
1194085000475	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1194085000476	heterotetramer interface [polypeptide binding]; other site
1194085000477	active site pocket [active]
1194085000478	cleavage site
1194085000479	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1194085000480	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1194085000481	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1194085000482	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1194085000483	inhibitor-cofactor binding pocket; inhibition site
1194085000484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085000485	catalytic residue [active]
1194085000486	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1194085000487	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1194085000488	Isochorismatase family; Region: Isochorismatase; pfam00857
1194085000489	catalytic triad [active]
1194085000490	conserved cis-peptide bond; other site
1194085000491	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1194085000492	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1194085000493	dimer interface [polypeptide binding]; other site
1194085000494	PYR/PP interface [polypeptide binding]; other site
1194085000495	TPP binding site [chemical binding]; other site
1194085000496	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1194085000497	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1194085000498	TPP-binding site [chemical binding]; other site
1194085000499	dimer interface [polypeptide binding]; other site
1194085000500	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1194085000501	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1194085000502	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1194085000503	active site turn [active]
1194085000504	phosphorylation site [posttranslational modification]
1194085000505	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1194085000506	HPr interaction site; other site
1194085000507	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1194085000508	active site
1194085000509	phosphorylation site [posttranslational modification]
1194085000510	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1194085000511	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1194085000512	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
1194085000513	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1194085000514	putative active site [active]
1194085000515	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1194085000516	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1194085000517	active site turn [active]
1194085000518	phosphorylation site [posttranslational modification]
1194085000519	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1194085000520	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1194085000521	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1194085000522	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1194085000523	putative active site [active]
1194085000524	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1194085000525	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1194085000526	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1194085000527	ATP binding site [chemical binding]; other site
1194085000528	putative Mg++ binding site [ion binding]; other site
1194085000529	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1194085000530	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085000531	Walker A/P-loop; other site
1194085000532	ATP binding site [chemical binding]; other site
1194085000533	Q-loop/lid; other site
1194085000534	ABC transporter signature motif; other site
1194085000535	Walker B; other site
1194085000536	D-loop; other site
1194085000537	H-loop/switch region; other site
1194085000538	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1194085000539	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085000540	Walker A/P-loop; other site
1194085000541	ATP binding site [chemical binding]; other site
1194085000542	Q-loop/lid; other site
1194085000543	ABC transporter signature motif; other site
1194085000544	Walker B; other site
1194085000545	D-loop; other site
1194085000546	H-loop/switch region; other site
1194085000547	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1194085000548	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1194085000549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085000550	dimer interface [polypeptide binding]; other site
1194085000551	conserved gate region; other site
1194085000552	putative PBP binding loops; other site
1194085000553	ABC-ATPase subunit interface; other site
1194085000554	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1194085000555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085000556	dimer interface [polypeptide binding]; other site
1194085000557	conserved gate region; other site
1194085000558	ABC-ATPase subunit interface; other site
1194085000559	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1194085000560	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1194085000561	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1194085000562	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1194085000563	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1194085000564	Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742
1194085000565	azoreductase; Reviewed; Region: PRK00170
1194085000566	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1194085000567	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1194085000568	Peptidase family M23; Region: Peptidase_M23; pfam01551
1194085000569	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1194085000570	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1194085000571	Walker A/P-loop; other site
1194085000572	ATP binding site [chemical binding]; other site
1194085000573	Q-loop/lid; other site
1194085000574	ABC transporter signature motif; other site
1194085000575	Walker B; other site
1194085000576	D-loop; other site
1194085000577	H-loop/switch region; other site
1194085000578	TOBE domain; Region: TOBE; pfam03459
1194085000579	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1194085000580	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1194085000581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085000582	dimer interface [polypeptide binding]; other site
1194085000583	conserved gate region; other site
1194085000584	ABC-ATPase subunit interface; other site
1194085000585	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1194085000586	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085000587	dimer interface [polypeptide binding]; other site
1194085000588	conserved gate region; other site
1194085000589	putative PBP binding loops; other site
1194085000590	ABC-ATPase subunit interface; other site
1194085000591	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1194085000592	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1194085000593	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1194085000594	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1194085000595	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1194085000596	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1194085000597	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1194085000598	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1194085000599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1194085000600	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1194085000601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085000602	putative substrate translocation pore; other site
1194085000603	Response regulator receiver domain; Region: Response_reg; pfam00072
1194085000604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085000605	active site
1194085000606	phosphorylation site [posttranslational modification]
1194085000607	intermolecular recognition site; other site
1194085000608	dimerization interface [polypeptide binding]; other site
1194085000609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1194085000610	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1194085000611	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1194085000612	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1194085000613	Histidine kinase; Region: His_kinase; pfam06580
1194085000614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085000615	ATP binding site [chemical binding]; other site
1194085000616	Mg2+ binding site [ion binding]; other site
1194085000617	G-X-G motif; other site
1194085000618	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1194085000619	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1194085000620	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1194085000621	Pyruvate formate lyase 1; Region: PFL1; cd01678
1194085000622	coenzyme A binding site [chemical binding]; other site
1194085000623	active site
1194085000624	catalytic residues [active]
1194085000625	glycine loop; other site
1194085000626	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1194085000627	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085000628	FeS/SAM binding site; other site
1194085000629	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1194085000630	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
1194085000631	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1194085000632	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1194085000633	putative active site [active]
1194085000634	catalytic site [active]
1194085000635	putative metal binding site [ion binding]; other site
1194085000636	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1194085000637	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1194085000638	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1194085000639	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1194085000640	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1194085000641	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1194085000642	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1194085000643	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1194085000644	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1194085000645	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1194085000646	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1194085000647	dimer interface [polypeptide binding]; other site
1194085000648	active site
1194085000649	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1194085000650	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1194085000651	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1194085000652	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1194085000653	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1194085000654	substrate binding site [chemical binding]; other site
1194085000655	oxyanion hole (OAH) forming residues; other site
1194085000656	trimer interface [polypeptide binding]; other site
1194085000657	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1194085000658	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1194085000659	active site
1194085000660	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1194085000661	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1194085000662	acyl-activating enzyme (AAE) consensus motif; other site
1194085000663	AMP binding site [chemical binding]; other site
1194085000664	active site
1194085000665	CoA binding site [chemical binding]; other site
1194085000666	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1194085000667	Coenzyme A transferase; Region: CoA_trans; smart00882
1194085000668	Coenzyme A transferase; Region: CoA_trans; cl17247
1194085000669	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1194085000670	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1194085000671	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1194085000672	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1194085000673	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1194085000674	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1194085000675	heme-binding site [chemical binding]; other site
1194085000676	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1194085000677	FAD binding pocket [chemical binding]; other site
1194085000678	FAD binding motif [chemical binding]; other site
1194085000679	phosphate binding motif [ion binding]; other site
1194085000680	beta-alpha-beta structure motif; other site
1194085000681	NAD binding pocket [chemical binding]; other site
1194085000682	Heme binding  pocket [chemical binding]; other site
1194085000683	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1194085000684	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1194085000685	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1194085000686	NAD binding site [chemical binding]; other site
1194085000687	dimer interface [polypeptide binding]; other site
1194085000688	substrate binding site [chemical binding]; other site
1194085000689	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1194085000690	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1194085000691	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1194085000692	active site turn [active]
1194085000693	phosphorylation site [posttranslational modification]
1194085000694	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1194085000695	active site
1194085000696	tetramer interface [polypeptide binding]; other site
1194085000697	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1194085000698	Mga helix-turn-helix domain; Region: Mga; pfam05043
1194085000699	PRD domain; Region: PRD; pfam00874
1194085000700	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1194085000701	active site
1194085000702	P-loop; other site
1194085000703	phosphorylation site [posttranslational modification]
1194085000704	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1194085000705	active site
1194085000706	phosphorylation site [posttranslational modification]
1194085000707	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1194085000708	active site
1194085000709	phosphorylation site [posttranslational modification]
1194085000710	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1194085000711	active site
1194085000712	P-loop; other site
1194085000713	phosphorylation site [posttranslational modification]
1194085000714	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1194085000715	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1194085000716	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1194085000717	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
1194085000718	putative NAD(P) binding site [chemical binding]; other site
1194085000719	catalytic Zn binding site [ion binding]; other site
1194085000720	structural Zn binding site [ion binding]; other site
1194085000721	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1194085000722	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
1194085000723	putative NAD(P) binding site [chemical binding]; other site
1194085000724	catalytic Zn binding site [ion binding]; other site
1194085000725	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1194085000726	substrate binding site; other site
1194085000727	dimer interface; other site
1194085000728	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1194085000729	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1194085000730	NAD(P) binding site [chemical binding]; other site
1194085000731	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1194085000732	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1194085000733	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1194085000734	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1194085000735	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1194085000736	substrate binding site; other site
1194085000737	dimer interface; other site
1194085000738	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
1194085000739	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1194085000740	putative NAD(P) binding site [chemical binding]; other site
1194085000741	putative catalytic Zn binding site [ion binding]; other site
1194085000742	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1194085000743	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1194085000744	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1194085000745	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1194085000746	active site
1194085000747	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
1194085000748	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1194085000749	Hemerythrin-like domain; Region: Hr-like; cd12108
1194085000750	Fe binding site [ion binding]; other site
1194085000751	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1194085000752	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1194085000753	Histidine kinase; Region: His_kinase; pfam06580
1194085000754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085000755	Mg2+ binding site [ion binding]; other site
1194085000756	G-X-G motif; other site
1194085000757	two-component response regulator; Provisional; Region: PRK14084
1194085000758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085000759	active site
1194085000760	phosphorylation site [posttranslational modification]
1194085000761	intermolecular recognition site; other site
1194085000762	dimerization interface [polypeptide binding]; other site
1194085000763	LytTr DNA-binding domain; Region: LytTR; pfam04397
1194085000764	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
1194085000765	antiholin-like protein LrgB; Provisional; Region: PRK04288
1194085000766	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1194085000767	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1194085000768	DNA-binding site [nucleotide binding]; DNA binding site
1194085000769	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1194085000770	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1194085000771	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1194085000772	HPr interaction site; other site
1194085000773	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1194085000774	active site
1194085000775	phosphorylation site [posttranslational modification]
1194085000776	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1194085000777	beta-galactosidase; Region: BGL; TIGR03356
1194085000778	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1194085000779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085000780	S-adenosylmethionine binding site [chemical binding]; other site
1194085000781	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1194085000782	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1194085000783	substrate binding site [chemical binding]; other site
1194085000784	dimer interface [polypeptide binding]; other site
1194085000785	ATP binding site [chemical binding]; other site
1194085000786	D-ribose pyranase; Provisional; Region: PRK11797
1194085000787	Sugar transport protein; Region: Sugar_transport; pfam06800
1194085000788	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1194085000789	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1194085000790	DNA binding site [nucleotide binding]
1194085000791	domain linker motif; other site
1194085000792	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1194085000793	dimerization interface [polypeptide binding]; other site
1194085000794	ligand binding site [chemical binding]; other site
1194085000795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085000796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085000797	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1194085000798	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1194085000799	active site
1194085000800	Surface antigen [General function prediction only]; Region: COG3942
1194085000801	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1194085000802	Peptidase family M23; Region: Peptidase_M23; pfam01551
1194085000803	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1194085000804	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1194085000805	Walker A/P-loop; other site
1194085000806	ATP binding site [chemical binding]; other site
1194085000807	Q-loop/lid; other site
1194085000808	ABC transporter signature motif; other site
1194085000809	Walker B; other site
1194085000810	D-loop; other site
1194085000811	H-loop/switch region; other site
1194085000812	Surface antigen [General function prediction only]; Region: COG3942
1194085000813	CHAP domain; Region: CHAP; pfam05257
1194085000814	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1194085000815	Predicted membrane protein [Function unknown]; Region: COG1511
1194085000816	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1194085000817	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1194085000818	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
1194085000819	Uncharacterized small protein [Function unknown]; Region: COG5417
1194085000820	Predicted membrane protein [Function unknown]; Region: COG4499
1194085000821	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1194085000822	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1194085000823	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1194085000824	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1194085000825	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1194085000826	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
1194085000827	LXG domain of WXG superfamily; Region: LXG; pfam04740
1194085000828	Protein of unknown function, DUF600; Region: DUF600; cl04640
1194085000829	Protein of unknown function, DUF600; Region: DUF600; cl04640
1194085000830	conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741
1194085000831	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1194085000832	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1194085000833	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1194085000834	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
1194085000835	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1194085000836	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1194085000837	FtsX-like permease family; Region: FtsX; pfam02687
1194085000838	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1194085000839	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1194085000840	Walker A/P-loop; other site
1194085000841	ATP binding site [chemical binding]; other site
1194085000842	Q-loop/lid; other site
1194085000843	ABC transporter signature motif; other site
1194085000844	Walker B; other site
1194085000845	D-loop; other site
1194085000846	H-loop/switch region; other site
1194085000847	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1194085000848	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1194085000849	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1194085000850	non-specific DNA binding site [nucleotide binding]; other site
1194085000851	salt bridge; other site
1194085000852	sequence-specific DNA binding site [nucleotide binding]; other site
1194085000853	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1194085000854	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1194085000855	substrate binding site [chemical binding]; other site
1194085000856	ATP binding site [chemical binding]; other site
1194085000857	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
1194085000858	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1194085000859	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1194085000860	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1194085000861	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
1194085000862	putative transporter; Provisional; Region: PRK10484
1194085000863	Na binding site [ion binding]; other site
1194085000864	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1194085000865	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1194085000866	inhibitor site; inhibition site
1194085000867	active site
1194085000868	dimer interface [polypeptide binding]; other site
1194085000869	catalytic residue [active]
1194085000870	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1194085000871	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1194085000872	nucleotide binding site [chemical binding]; other site
1194085000873	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1194085000874	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1194085000875	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1194085000876	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1194085000877	putative active site [active]
1194085000878	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1194085000879	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1194085000880	putative active site cavity [active]
1194085000881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1194085000882	Nucleoside recognition; Region: Gate; pfam07670
1194085000883	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1194085000884	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1194085000885	PGAP1-like protein; Region: PGAP1; pfam07819
1194085000886	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1194085000887	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1194085000888	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1194085000889	putative active site [active]
1194085000890	putative FMN binding site [chemical binding]; other site
1194085000891	putative substrate binding site [chemical binding]; other site
1194085000892	putative catalytic residue [active]
1194085000893	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1194085000894	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1194085000895	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1194085000896	lipoyl attachment site [posttranslational modification]; other site
1194085000897	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1194085000898	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
1194085000899	putative ADP-ribose binding site [chemical binding]; other site
1194085000900	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
1194085000901	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1194085000902	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1194085000903	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1194085000904	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1194085000905	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1194085000906	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1194085000907	active site
1194085000908	P-loop; other site
1194085000909	phosphorylation site [posttranslational modification]
1194085000910	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1194085000911	active site
1194085000912	phosphorylation site [posttranslational modification]
1194085000913	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1194085000914	HTH domain; Region: HTH_11; pfam08279
1194085000915	HTH domain; Region: HTH_11; pfam08279
1194085000916	PRD domain; Region: PRD; pfam00874
1194085000917	PRD domain; Region: PRD; pfam00874
1194085000918	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1194085000919	active site
1194085000920	P-loop; other site
1194085000921	phosphorylation site [posttranslational modification]
1194085000922	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1194085000923	active site
1194085000924	phosphorylation site [posttranslational modification]
1194085000925	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1194085000926	MarR family; Region: MarR_2; pfam12802
1194085000927	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1194085000928	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1194085000929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
1194085000930	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1194085000931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085000932	putative substrate translocation pore; other site
1194085000933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085000934	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1194085000935	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1194085000936	Zn binding site [ion binding]; other site
1194085000937	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1194085000938	Zn binding site [ion binding]; other site
1194085000939	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1194085000940	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1194085000941	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1194085000942	Predicted flavoprotein [General function prediction only]; Region: COG0431
1194085000943	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1194085000944	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
1194085000945	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1194085000946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1194085000947	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
1194085000948	Imelysin; Region: Peptidase_M75; pfam09375
1194085000949	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1194085000950	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1194085000951	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1194085000952	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1194085000953	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1194085000954	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
1194085000955	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1194085000956	non-specific DNA binding site [nucleotide binding]; other site
1194085000957	salt bridge; other site
1194085000958	sequence-specific DNA binding site [nucleotide binding]; other site
1194085000959	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
1194085000960	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1194085000961	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1194085000962	Walker A/P-loop; other site
1194085000963	ATP binding site [chemical binding]; other site
1194085000964	Q-loop/lid; other site
1194085000965	ABC transporter signature motif; other site
1194085000966	Walker B; other site
1194085000967	D-loop; other site
1194085000968	H-loop/switch region; other site
1194085000969	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1194085000970	Predicted membrane protein [Function unknown]; Region: COG4292
1194085000971	putative acyltransferase; Provisional; Region: PRK05790
1194085000972	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1194085000973	dimer interface [polypeptide binding]; other site
1194085000974	active site
1194085000975	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1194085000976	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1194085000977	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
1194085000978	THF binding site; other site
1194085000979	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1194085000980	substrate binding site [chemical binding]; other site
1194085000981	THF binding site; other site
1194085000982	zinc-binding site [ion binding]; other site
1194085000983	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1194085000984	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1194085000985	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1194085000986	FAD binding site [chemical binding]; other site
1194085000987	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1194085000988	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1194085000989	homodimer interface [polypeptide binding]; other site
1194085000990	substrate-cofactor binding pocket; other site
1194085000991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085000992	catalytic residue [active]
1194085000993	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1194085000994	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1194085000995	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1194085000996	catalytic residue [active]
1194085000997	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1194085000998	ParB-like nuclease domain; Region: ParB; smart00470
1194085000999	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1194085001000	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1194085001001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
1194085001002	GTP-binding protein YchF; Reviewed; Region: PRK09601
1194085001003	YchF GTPase; Region: YchF; cd01900
1194085001004	G1 box; other site
1194085001005	GTP/Mg2+ binding site [chemical binding]; other site
1194085001006	Switch I region; other site
1194085001007	G2 box; other site
1194085001008	Switch II region; other site
1194085001009	G3 box; other site
1194085001010	G4 box; other site
1194085001011	G5 box; other site
1194085001012	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1194085001013	Winged helix-turn helix; Region: HTH_29; pfam13551
1194085001014	Integrase core domain; Region: rve; pfam00665
1194085001015	transposase/IS protein; Provisional; Region: PRK09183
1194085001016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085001017	Walker A motif; other site
1194085001018	ATP binding site [chemical binding]; other site
1194085001019	Walker B motif; other site
1194085001020	arginine finger; other site
1194085001021	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1194085001022	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1194085001023	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1194085001024	dimer interface [polypeptide binding]; other site
1194085001025	ssDNA binding site [nucleotide binding]; other site
1194085001026	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1194085001027	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1194085001028	Abi-like protein; Region: Abi_2; pfam07751
1194085001029	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1194085001031	Predicted membrane protein [Function unknown]; Region: COG3212
1194085001032	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1194085001033	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1194085001034	non-specific DNA binding site [nucleotide binding]; other site
1194085001035	salt bridge; other site
1194085001036	sequence-specific DNA binding site [nucleotide binding]; other site
1194085001037	Predicted membrane protein [Function unknown]; Region: COG2261
1194085001038	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1194085001039	catalytic core [active]
1194085001040	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1194085001041	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1194085001042	catalytic residue [active]
1194085001043	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1194085001044	catalytic residues [active]
1194085001045	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1194085001046	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085001047	peroxiredoxin; Region: AhpC; TIGR03137
1194085001048	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1194085001049	dimer interface [polypeptide binding]; other site
1194085001050	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1194085001051	catalytic triad [active]
1194085001052	peroxidatic and resolving cysteines [active]
1194085001053	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1194085001054	dimer interface [polypeptide binding]; other site
1194085001055	FMN binding site [chemical binding]; other site
1194085001056	NADPH bind site [chemical binding]; other site
1194085001057	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1194085001058	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1194085001059	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1194085001060	active site
1194085001061	xanthine permease; Region: pbuX; TIGR03173
1194085001062	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1194085001063	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1194085001064	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1194085001065	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1194085001066	active site
1194085001067	GMP synthase; Reviewed; Region: guaA; PRK00074
1194085001068	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1194085001069	AMP/PPi binding site [chemical binding]; other site
1194085001070	candidate oxyanion hole; other site
1194085001071	catalytic triad [active]
1194085001072	potential glutamine specificity residues [chemical binding]; other site
1194085001073	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1194085001074	ATP Binding subdomain [chemical binding]; other site
1194085001075	Ligand Binding sites [chemical binding]; other site
1194085001076	Dimerization subdomain; other site
1194085001077	Abi-like protein; Region: Abi_2; pfam07751
1194085001078	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
1194085001079	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1194085001080	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
1194085001081	Divergent AAA domain; Region: AAA_4; pfam04326
1194085001082	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1194085001083	Predicted membrane protein [Function unknown]; Region: COG3759
1194085001084	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1194085001085	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1194085001086	NADP binding site [chemical binding]; other site
1194085001087	superantigen-like protein; Reviewed; Region: PRK13037
1194085001088	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001089	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001090	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1194085001091	superantigen-like protein; Reviewed; Region: PRK13041
1194085001092	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001093	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001094	superantigen-like protein; Reviewed; Region: PRK13335
1194085001095	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001096	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001097	superantigen-like protein; Reviewed; Region: PRK13042
1194085001098	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001099	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001100	superantigen-like protein 5; Reviewed; Region: PRK13035
1194085001101	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001102	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001103	superantigen-like protein 7; Reviewed; Region: PRK13346
1194085001104	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001105	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001106	superantigen-like protein; Reviewed; Region: PRK13039
1194085001107	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001108	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001109	superantigen-like protein; Reviewed; Region: PRK13345
1194085001110	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001111	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001112	superantigen-like protein; Reviewed; Region: PRK13038
1194085001113	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001114	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001115	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1194085001116	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1194085001117	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1194085001118	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1194085001119	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1194085001120	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1194085001121	superantigen-like protein; Reviewed; Region: PRK13036
1194085001122	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1194085001123	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085001124	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085001125	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085001126	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085001127	Protein of unknown function, DUF576; Region: DUF576; cl04553
1194085001128	transposase/IS protein; Provisional; Region: PRK09183
1194085001129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085001130	Walker A motif; other site
1194085001131	ATP binding site [chemical binding]; other site
1194085001132	Walker B motif; other site
1194085001133	arginine finger; other site
1194085001134	Winged helix-turn helix; Region: HTH_29; pfam13551
1194085001135	Integrase core domain; Region: rve; pfam00665
1194085001136	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085001137	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085001138	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085001139	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085001140	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1194085001141	nucleophilic elbow; other site
1194085001142	catalytic triad; other site
1194085001143	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1194085001144	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1194085001145	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1194085001146	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1194085001147	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1194085001148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1194085001149	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1194085001150	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
1194085001151	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1194085001152	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1194085001153	active site
1194085001154	Esterase/lipase [General function prediction only]; Region: COG1647
1194085001155	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1194085001156	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1194085001157	Na2 binding site [ion binding]; other site
1194085001158	putative substrate binding site 1 [chemical binding]; other site
1194085001159	Na binding site 1 [ion binding]; other site
1194085001160	putative substrate binding site 2 [chemical binding]; other site
1194085001161	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1194085001162	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1194085001163	dimer interface [polypeptide binding]; other site
1194085001164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085001165	catalytic residue [active]
1194085001166	cystathionine beta-lyase; Provisional; Region: PRK07671
1194085001167	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1194085001168	homodimer interface [polypeptide binding]; other site
1194085001169	substrate-cofactor binding pocket; other site
1194085001170	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085001171	catalytic residue [active]
1194085001172	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1194085001173	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1194085001174	Walker A/P-loop; other site
1194085001175	ATP binding site [chemical binding]; other site
1194085001176	Q-loop/lid; other site
1194085001177	ABC transporter signature motif; other site
1194085001178	Walker B; other site
1194085001179	D-loop; other site
1194085001180	H-loop/switch region; other site
1194085001181	NIL domain; Region: NIL; pfam09383
1194085001182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085001183	dimer interface [polypeptide binding]; other site
1194085001184	conserved gate region; other site
1194085001185	ABC-ATPase subunit interface; other site
1194085001186	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1194085001187	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1194085001188	LysM domain; Region: LysM; pfam01476
1194085001189	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1194085001190	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1194085001191	Surface antigen [General function prediction only]; Region: COG3942
1194085001192	CHAP domain; Region: CHAP; pfam05257
1194085001193	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1194085001194	nudix motif; other site
1194085001195	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085001196	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1194085001197	Coenzyme A binding pocket [chemical binding]; other site
1194085001198	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1194085001199	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1194085001200	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1194085001201	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1194085001202	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1194085001203	dimerization interface [polypeptide binding]; other site
1194085001204	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1194085001205	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1194085001206	active site
1194085001207	dimer interface [polypeptide binding]; other site
1194085001208	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1194085001209	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1194085001210	active site
1194085001211	FMN binding site [chemical binding]; other site
1194085001212	substrate binding site [chemical binding]; other site
1194085001213	3Fe-4S cluster binding site [ion binding]; other site
1194085001214	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1194085001215	domain interface; other site
1194085001216	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1194085001217	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1194085001218	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1194085001219	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1194085001220	active site turn [active]
1194085001221	phosphorylation site [posttranslational modification]
1194085001222	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1194085001223	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1194085001224	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1194085001225	Ca binding site [ion binding]; other site
1194085001226	active site
1194085001227	catalytic site [active]
1194085001228	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1194085001229	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1194085001230	DNA-binding site [nucleotide binding]; DNA binding site
1194085001231	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1194085001232	UTRA domain; Region: UTRA; pfam07702
1194085001233	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1194085001234	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085001235	Coenzyme A binding pocket [chemical binding]; other site
1194085001236	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1194085001237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085001238	Walker A motif; other site
1194085001239	ATP binding site [chemical binding]; other site
1194085001240	Walker B motif; other site
1194085001241	arginine finger; other site
1194085001242	hypothetical protein; Validated; Region: PRK00153
1194085001243	recombination protein RecR; Reviewed; Region: recR; PRK00076
1194085001244	RecR protein; Region: RecR; pfam02132
1194085001245	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1194085001246	putative active site [active]
1194085001247	putative metal-binding site [ion binding]; other site
1194085001248	tetramer interface [polypeptide binding]; other site
1194085001249	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1194085001250	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1194085001251	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1194085001252	catalytic residue [active]
1194085001253	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1194085001254	thymidylate kinase; Validated; Region: tmk; PRK00698
1194085001255	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1194085001256	TMP-binding site; other site
1194085001257	ATP-binding site [chemical binding]; other site
1194085001258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
1194085001259	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1194085001260	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1194085001261	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1194085001262	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
1194085001263	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1194085001264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085001265	S-adenosylmethionine binding site [chemical binding]; other site
1194085001266	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1194085001267	GIY-YIG motif/motif A; other site
1194085001268	putative active site [active]
1194085001269	putative metal binding site [ion binding]; other site
1194085001270	Predicted methyltransferases [General function prediction only]; Region: COG0313
1194085001271	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1194085001272	putative SAM binding site [chemical binding]; other site
1194085001273	putative homodimer interface [polypeptide binding]; other site
1194085001274	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1194085001275	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1194085001276	active site
1194085001277	HIGH motif; other site
1194085001278	KMSKS motif; other site
1194085001279	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1194085001280	tRNA binding surface [nucleotide binding]; other site
1194085001281	anticodon binding site; other site
1194085001282	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1194085001283	dimer interface [polypeptide binding]; other site
1194085001284	putative tRNA-binding site [nucleotide binding]; other site
1194085001285	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1194085001286	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1194085001287	active site
1194085001288	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1194085001289	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1194085001290	putative active site [active]
1194085001291	putative metal binding site [ion binding]; other site
1194085001292	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1194085001293	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1194085001294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085001295	S-adenosylmethionine binding site [chemical binding]; other site
1194085001296	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1194085001297	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1194085001298	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1194085001299	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1194085001300	pur operon repressor; Provisional; Region: PRK09213
1194085001301	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1194085001302	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1194085001303	active site
1194085001304	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1194085001305	homotrimer interaction site [polypeptide binding]; other site
1194085001306	putative active site [active]
1194085001307	regulatory protein SpoVG; Reviewed; Region: PRK13259
1194085001308	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1194085001309	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1194085001310	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1194085001311	Substrate binding site; other site
1194085001312	Mg++ binding site; other site
1194085001313	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1194085001314	active site
1194085001315	substrate binding site [chemical binding]; other site
1194085001316	CoA binding site [chemical binding]; other site
1194085001317	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1194085001318	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1194085001319	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1194085001320	active site
1194085001321	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1194085001322	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1194085001323	5S rRNA interface [nucleotide binding]; other site
1194085001324	CTC domain interface [polypeptide binding]; other site
1194085001325	L16 interface [polypeptide binding]; other site
1194085001326	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1194085001327	putative active site [active]
1194085001328	catalytic residue [active]
1194085001329	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1194085001330	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
1194085001331	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1194085001332	ATP binding site [chemical binding]; other site
1194085001333	putative Mg++ binding site [ion binding]; other site
1194085001334	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1194085001335	nucleotide binding region [chemical binding]; other site
1194085001336	ATP-binding site [chemical binding]; other site
1194085001337	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1194085001338	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1194085001339	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1194085001340	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1194085001341	putative SAM binding site [chemical binding]; other site
1194085001342	putative homodimer interface [polypeptide binding]; other site
1194085001343	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1194085001344	homodimer interface [polypeptide binding]; other site
1194085001345	metal binding site [ion binding]; metal-binding site
1194085001346	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1194085001347	RNA binding surface [nucleotide binding]; other site
1194085001348	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1194085001349	Septum formation initiator; Region: DivIC; pfam04977
1194085001350	hypothetical protein; Provisional; Region: PRK08582
1194085001351	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1194085001352	RNA binding site [nucleotide binding]; other site
1194085001353	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1194085001354	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1194085001355	Ligand Binding Site [chemical binding]; other site
1194085001356	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1194085001357	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1194085001358	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1194085001359	active site
1194085001360	FtsH Extracellular; Region: FtsH_ext; pfam06480
1194085001361	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1194085001362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085001363	Walker A motif; other site
1194085001364	ATP binding site [chemical binding]; other site
1194085001365	Walker B motif; other site
1194085001366	arginine finger; other site
1194085001367	Peptidase family M41; Region: Peptidase_M41; pfam01434
1194085001368	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1194085001369	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1194085001370	dimerization interface [polypeptide binding]; other site
1194085001371	domain crossover interface; other site
1194085001372	redox-dependent activation switch; other site
1194085001373	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1194085001374	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1194085001375	dimer interface [polypeptide binding]; other site
1194085001376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085001377	catalytic residue [active]
1194085001378	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1194085001379	dihydropteroate synthase; Region: DHPS; TIGR01496
1194085001380	substrate binding pocket [chemical binding]; other site
1194085001381	dimer interface [polypeptide binding]; other site
1194085001382	inhibitor binding site; inhibition site
1194085001383	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1194085001384	homooctamer interface [polypeptide binding]; other site
1194085001385	active site
1194085001386	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1194085001387	catalytic center binding site [active]
1194085001388	ATP binding site [chemical binding]; other site
1194085001389	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1194085001390	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1194085001391	dimer interface [polypeptide binding]; other site
1194085001392	putative anticodon binding site; other site
1194085001393	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1194085001394	motif 1; other site
1194085001395	active site
1194085001396	motif 2; other site
1194085001397	motif 3; other site
1194085001398	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1194085001399	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1194085001400	DNA-binding site [nucleotide binding]; DNA binding site
1194085001401	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1194085001402	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085001403	homodimer interface [polypeptide binding]; other site
1194085001404	catalytic residue [active]
1194085001405	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1194085001406	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1194085001407	active site
1194085001408	multimer interface [polypeptide binding]; other site
1194085001409	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1194085001410	predicted active site [active]
1194085001411	catalytic triad [active]
1194085001412	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1194085001413	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1194085001414	Nucleoside recognition; Region: Gate; pfam07670
1194085001415	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1194085001416	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
1194085001417	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1194085001418	UvrB/uvrC motif; Region: UVR; pfam02151
1194085001419	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
1194085001420	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1194085001421	ADP binding site [chemical binding]; other site
1194085001422	phosphagen binding site; other site
1194085001423	substrate specificity loop; other site
1194085001424	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1194085001425	Clp amino terminal domain; Region: Clp_N; pfam02861
1194085001426	Clp amino terminal domain; Region: Clp_N; pfam02861
1194085001427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085001428	Walker A motif; other site
1194085001429	ATP binding site [chemical binding]; other site
1194085001430	Walker B motif; other site
1194085001431	arginine finger; other site
1194085001432	UvrB/uvrC motif; Region: UVR; pfam02151
1194085001433	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085001434	Walker A motif; other site
1194085001435	ATP binding site [chemical binding]; other site
1194085001436	Walker B motif; other site
1194085001437	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1194085001438	DNA repair protein RadA; Provisional; Region: PRK11823
1194085001439	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1194085001440	Walker A motif/ATP binding site; other site
1194085001441	ATP binding site [chemical binding]; other site
1194085001442	Walker B motif; other site
1194085001443	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1194085001444	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1194085001445	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1194085001446	putative active site [active]
1194085001447	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1194085001448	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1194085001449	active site
1194085001450	HIGH motif; other site
1194085001451	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1194085001452	active site
1194085001453	KMSKS motif; other site
1194085001454	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1194085001455	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1194085001456	trimer interface [polypeptide binding]; other site
1194085001457	active site
1194085001458	substrate binding site [chemical binding]; other site
1194085001459	CoA binding site [chemical binding]; other site
1194085001460	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1194085001461	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1194085001462	active site
1194085001463	HIGH motif; other site
1194085001464	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1194085001465	KMSKS motif; other site
1194085001466	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1194085001467	tRNA binding surface [nucleotide binding]; other site
1194085001468	anticodon binding site; other site
1194085001469	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1194085001470	active site
1194085001471	dimerization interface [polypeptide binding]; other site
1194085001472	metal binding site [ion binding]; metal-binding site
1194085001473	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1194085001474	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1194085001475	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1194085001476	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
1194085001477	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1194085001478	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1194085001479	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1194085001480	DNA binding residues [nucleotide binding]
1194085001481	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1194085001482	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1194085001483	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1194085001484	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1194085001485	putative homodimer interface [polypeptide binding]; other site
1194085001486	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1194085001487	heterodimer interface [polypeptide binding]; other site
1194085001488	homodimer interface [polypeptide binding]; other site
1194085001489	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1194085001490	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1194085001491	23S rRNA interface [nucleotide binding]; other site
1194085001492	L7/L12 interface [polypeptide binding]; other site
1194085001493	putative thiostrepton binding site; other site
1194085001494	L25 interface [polypeptide binding]; other site
1194085001495	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1194085001496	mRNA/rRNA interface [nucleotide binding]; other site
1194085001497	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1194085001498	23S rRNA interface [nucleotide binding]; other site
1194085001499	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1194085001500	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1194085001501	peripheral dimer interface [polypeptide binding]; other site
1194085001502	core dimer interface [polypeptide binding]; other site
1194085001503	L10 interface [polypeptide binding]; other site
1194085001504	L11 interface [polypeptide binding]; other site
1194085001505	putative EF-Tu interaction site [polypeptide binding]; other site
1194085001506	putative EF-G interaction site [polypeptide binding]; other site
1194085001507	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1194085001508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085001509	S-adenosylmethionine binding site [chemical binding]; other site
1194085001510	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1194085001511	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1194085001512	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1194085001513	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1194085001514	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1194085001515	RPB10 interaction site [polypeptide binding]; other site
1194085001516	RPB1 interaction site [polypeptide binding]; other site
1194085001517	RPB11 interaction site [polypeptide binding]; other site
1194085001518	RPB3 interaction site [polypeptide binding]; other site
1194085001519	RPB12 interaction site [polypeptide binding]; other site
1194085001520	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1194085001521	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1194085001522	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1194085001523	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1194085001524	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1194085001525	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1194085001526	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1194085001527	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1194085001528	G-loop; other site
1194085001529	DNA binding site [nucleotide binding]
1194085001530	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
1194085001531	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1194085001532	S17 interaction site [polypeptide binding]; other site
1194085001533	S8 interaction site; other site
1194085001534	16S rRNA interaction site [nucleotide binding]; other site
1194085001535	streptomycin interaction site [chemical binding]; other site
1194085001536	23S rRNA interaction site [nucleotide binding]; other site
1194085001537	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1194085001538	30S ribosomal protein S7; Validated; Region: PRK05302
1194085001539	elongation factor G; Reviewed; Region: PRK00007
1194085001540	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1194085001541	G1 box; other site
1194085001542	putative GEF interaction site [polypeptide binding]; other site
1194085001543	GTP/Mg2+ binding site [chemical binding]; other site
1194085001544	Switch I region; other site
1194085001545	G2 box; other site
1194085001546	G3 box; other site
1194085001547	Switch II region; other site
1194085001548	G4 box; other site
1194085001549	G5 box; other site
1194085001550	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1194085001551	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1194085001552	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1194085001553	elongation factor Tu; Reviewed; Region: PRK00049
1194085001554	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1194085001555	G1 box; other site
1194085001556	GEF interaction site [polypeptide binding]; other site
1194085001557	GTP/Mg2+ binding site [chemical binding]; other site
1194085001558	Switch I region; other site
1194085001559	G2 box; other site
1194085001560	G3 box; other site
1194085001561	Switch II region; other site
1194085001562	G4 box; other site
1194085001563	G5 box; other site
1194085001564	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1194085001565	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1194085001566	Antibiotic Binding Site [chemical binding]; other site
1194085001567	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1194085001568	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1194085001569	metal binding site [ion binding]; metal-binding site
1194085001570	dimer interface [polypeptide binding]; other site
1194085001571	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1194085001572	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1194085001573	substrate-cofactor binding pocket; other site
1194085001574	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085001575	catalytic residue [active]
1194085001576	chaperone protein HchA; Provisional; Region: PRK04155
1194085001577	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1194085001578	conserved cys residue [active]
1194085001579	ribulokinase; Provisional; Region: PRK04123
1194085001580	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1194085001581	N- and C-terminal domain interface [polypeptide binding]; other site
1194085001582	active site
1194085001583	MgATP binding site [chemical binding]; other site
1194085001584	catalytic site [active]
1194085001585	metal binding site [ion binding]; metal-binding site
1194085001586	carbohydrate binding site [chemical binding]; other site
1194085001587	homodimer interface [polypeptide binding]; other site
1194085001588	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1194085001589	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1194085001590	NAD(P) binding site [chemical binding]; other site
1194085001591	active site
1194085001592	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1194085001593	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1194085001594	homodimer interface [polypeptide binding]; other site
1194085001595	substrate-cofactor binding pocket; other site
1194085001596	catalytic residue [active]
1194085001597	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1194085001598	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085001599	motif II; other site
1194085001600	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1194085001601	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1194085001602	Substrate-binding site [chemical binding]; other site
1194085001603	Substrate specificity [chemical binding]; other site
1194085001604	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1194085001605	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1194085001606	Substrate-binding site [chemical binding]; other site
1194085001607	Substrate specificity [chemical binding]; other site
1194085001608	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1194085001609	nucleoside/Zn binding site; other site
1194085001610	dimer interface [polypeptide binding]; other site
1194085001611	catalytic motif [active]
1194085001612	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1194085001613	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085001614	active site
1194085001615	motif I; other site
1194085001616	motif II; other site
1194085001617	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085001618	Predicted flavoprotein [General function prediction only]; Region: COG0431
1194085001619	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1194085001620	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1194085001621	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1194085001622	Cna protein B-type domain; Region: Cna_B; pfam05738
1194085001623	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1194085001624	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1194085001625	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1194085001626	Cna protein B-type domain; Region: Cna_B; pfam05738
1194085001627	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1194085001628	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1194085001629	Cna protein B-type domain; Region: Cna_B; pfam05738
1194085001630	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1194085001631	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1194085001632	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1194085001633	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1194085001634	Cna protein B-type domain; Region: Cna_B; pfam05738
1194085001635	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1194085001636	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1194085001637	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1194085001638	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1194085001639	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1194085001640	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1194085001641	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1194085001642	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085001643	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085001644	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1194085001645	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085001646	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1194085001647	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
1194085001648	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
1194085001649	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1194085001650	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1194085001651	active site
1194085001652	trimer interface [polypeptide binding]; other site
1194085001653	allosteric site; other site
1194085001654	active site lid [active]
1194085001655	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1194085001656	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1194085001657	active site
1194085001658	dimer interface [polypeptide binding]; other site
1194085001659	magnesium binding site [ion binding]; other site
1194085001660	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1194085001661	tetramer interface [polypeptide binding]; other site
1194085001662	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1194085001663	active site
1194085001664	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1194085001665	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085001666	motif II; other site
1194085001667	proline/glycine betaine transporter; Provisional; Region: PRK10642
1194085001668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085001669	putative substrate translocation pore; other site
1194085001670	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1194085001671	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1194085001672	acyl-activating enzyme (AAE) consensus motif; other site
1194085001673	AMP binding site [chemical binding]; other site
1194085001674	active site
1194085001675	CoA binding site [chemical binding]; other site
1194085001676	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1194085001677	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1194085001678	dimer interface [polypeptide binding]; other site
1194085001679	active site
1194085001680	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1194085001681	dimer interface [polypeptide binding]; other site
1194085001682	substrate binding site [chemical binding]; other site
1194085001683	ATP binding site [chemical binding]; other site
1194085001684	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1194085001685	ligand binding site [chemical binding]; other site
1194085001686	active site
1194085001687	UGI interface [polypeptide binding]; other site
1194085001688	catalytic site [active]
1194085001689	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1194085001690	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1194085001691	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1194085001692	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1194085001693	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1194085001694	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1194085001695	putative heme peroxidase; Provisional; Region: PRK12276
1194085001696	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1194085001697	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1194085001698	mevalonate kinase; Region: mevalon_kin; TIGR00549
1194085001699	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1194085001700	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1194085001701	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
1194085001702	diphosphomevalonate decarboxylase; Region: PLN02407
1194085001703	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1194085001704	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1194085001705	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1194085001706	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1194085001707	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1194085001708	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1194085001709	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085001710	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1194085001711	Predicted transcriptional regulator [Transcription]; Region: COG1959
1194085001712	Transcriptional regulator; Region: Rrf2; pfam02082
1194085001713	LXG domain of WXG superfamily; Region: LXG; pfam04740
1194085001714	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1194085001715	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1194085001716	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1194085001717	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1194085001718	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1194085001719	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1194085001720	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1194085001721	active site
1194085001722	catalytic tetrad [active]
1194085001723	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1194085001724	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1194085001725	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1194085001726	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085001727	Coenzyme A binding pocket [chemical binding]; other site
1194085001728	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1194085001729	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1194085001730	Zn2+ binding site [ion binding]; other site
1194085001731	Mg2+ binding site [ion binding]; other site
1194085001732	YwhD family; Region: YwhD; pfam08741
1194085001733	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1194085001734	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1194085001735	NAD binding site [chemical binding]; other site
1194085001736	substrate binding site [chemical binding]; other site
1194085001737	catalytic Zn binding site [ion binding]; other site
1194085001738	tetramer interface [polypeptide binding]; other site
1194085001739	structural Zn binding site [ion binding]; other site
1194085001740	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
1194085001741	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1194085001742	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
1194085001743	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1194085001744	active site
1194085001745	HIGH motif; other site
1194085001746	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1194085001747	KMSK motif region; other site
1194085001748	tRNA binding surface [nucleotide binding]; other site
1194085001749	DALR anticodon binding domain; Region: DALR_1; smart00836
1194085001750	anticodon binding site; other site
1194085001751	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
1194085001752	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1194085001753	minor groove reading motif; other site
1194085001754	helix-hairpin-helix signature motif; other site
1194085001755	substrate binding pocket [chemical binding]; other site
1194085001756	active site
1194085001757	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1194085001758	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1194085001759	putative binding site residues; other site
1194085001760	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1194085001761	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1194085001762	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085001763	ABC-ATPase subunit  interface; other site
1194085001764	dimer interface [polypeptide binding]; other site
1194085001765	putative PBP binding regions; other site
1194085001766	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1194085001767	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085001768	motif II; other site
1194085001769	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1194085001770	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1194085001771	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1194085001772	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1194085001773	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085001774	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1194085001775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1194085001776	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1194085001777	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1194085001778	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1194085001779	active site
1194085001780	DNA binding site [nucleotide binding]
1194085001781	Int/Topo IB signature motif; other site
1194085001782	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
1194085001783	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1194085001784	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1194085001785	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
1194085001786	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
1194085001787	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
1194085001788	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1194085001789	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1194085001790	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
1194085001791	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
1194085001792	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1194085001793	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1194085001794	metal binding site [ion binding]; metal-binding site
1194085001795	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1194085001796	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085001797	ABC-ATPase subunit  interface; other site
1194085001798	dimer interface [polypeptide binding]; other site
1194085001799	putative PBP binding regions; other site
1194085001800	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1194085001801	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1194085001802	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1194085001803	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1194085001804	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1194085001805	FeoA domain; Region: FeoA; pfam04023
1194085001806	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1194085001807	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1194085001808	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1194085001809	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
1194085001810	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1194085001811	Walker A/P-loop; other site
1194085001812	ATP binding site [chemical binding]; other site
1194085001813	Q-loop/lid; other site
1194085001814	ABC transporter signature motif; other site
1194085001815	Walker B; other site
1194085001816	D-loop; other site
1194085001817	H-loop/switch region; other site
1194085001818	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1194085001819	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1194085001820	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1194085001821	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1194085001822	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1194085001823	active site
1194085001824	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1194085001825	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1194085001826	active site
1194085001827	nucleotide binding site [chemical binding]; other site
1194085001828	HIGH motif; other site
1194085001829	KMSKS motif; other site
1194085001830	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1194085001831	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1194085001832	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
1194085001833	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1194085001834	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1194085001835	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085001836	Walker A/P-loop; other site
1194085001837	ATP binding site [chemical binding]; other site
1194085001838	Q-loop/lid; other site
1194085001839	ABC transporter signature motif; other site
1194085001840	Walker B; other site
1194085001841	D-loop; other site
1194085001842	H-loop/switch region; other site
1194085001843	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1194085001844	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1194085001845	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1194085001846	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1194085001847	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1194085001848	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1194085001849	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1194085001850	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1194085001851	Walker A/P-loop; other site
1194085001852	ATP binding site [chemical binding]; other site
1194085001853	Q-loop/lid; other site
1194085001854	ABC transporter signature motif; other site
1194085001855	Walker B; other site
1194085001856	D-loop; other site
1194085001857	H-loop/switch region; other site
1194085001858	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1194085001859	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085001860	ABC-ATPase subunit  interface; other site
1194085001861	dimer interface [polypeptide binding]; other site
1194085001862	putative PBP binding regions; other site
1194085001863	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1194085001864	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085001865	ABC-ATPase subunit  interface; other site
1194085001866	dimer interface [polypeptide binding]; other site
1194085001867	putative PBP binding regions; other site
1194085001868	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1194085001869	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1194085001870	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1194085001871	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1194085001872	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
1194085001873	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1194085001874	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1194085001875	Na binding site [ion binding]; other site
1194085001876	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1194085001877	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1194085001878	substrate binding pocket [chemical binding]; other site
1194085001879	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1194085001880	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1194085001881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085001882	Coenzyme A binding pocket [chemical binding]; other site
1194085001883	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1194085001884	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1194085001885	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1194085001886	NAD(P) binding site [chemical binding]; other site
1194085001887	active site
1194085001888	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1194085001889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085001890	active site
1194085001891	phosphorylation site [posttranslational modification]
1194085001892	intermolecular recognition site; other site
1194085001893	dimerization interface [polypeptide binding]; other site
1194085001894	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1194085001895	DNA binding site [nucleotide binding]
1194085001896	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1194085001897	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1194085001898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085001899	ATP binding site [chemical binding]; other site
1194085001900	Mg2+ binding site [ion binding]; other site
1194085001901	G-X-G motif; other site
1194085001902	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1194085001903	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1194085001904	Walker A/P-loop; other site
1194085001905	ATP binding site [chemical binding]; other site
1194085001906	Q-loop/lid; other site
1194085001907	ABC transporter signature motif; other site
1194085001908	Walker B; other site
1194085001909	D-loop; other site
1194085001910	H-loop/switch region; other site
1194085001911	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1194085001912	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1194085001913	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1194085001914	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1194085001915	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1194085001916	Surface antigen [General function prediction only]; Region: COG3942
1194085001917	CHAP domain; Region: CHAP; pfam05257
1194085001918	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1194085001919	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
1194085001920	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1194085001921	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085001922	hypothetical protein; Provisional; Region: PRK12378
1194085001923	Uncharacterized conserved protein [Function unknown]; Region: COG3542
1194085001924	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1194085001925	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1194085001926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1194085001927	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1194085001928	dimerization interface [polypeptide binding]; other site
1194085001929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085001930	sugar efflux transporter; Region: 2A0120; TIGR00899
1194085001931	putative substrate translocation pore; other site
1194085001932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
1194085001933	Serine incorporator (Serinc); Region: Serinc; pfam03348
1194085001934	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1194085001935	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085001936	Coenzyme A binding pocket [chemical binding]; other site
1194085001937	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1194085001938	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1194085001939	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
1194085001940	hypothetical protein; Validated; Region: PRK00124
1194085001941	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1194085001942	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1194085001943	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1194085001944	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1194085001945	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1194085001946	Walker A/P-loop; other site
1194085001947	ATP binding site [chemical binding]; other site
1194085001948	Q-loop/lid; other site
1194085001949	ABC transporter signature motif; other site
1194085001950	Walker B; other site
1194085001951	D-loop; other site
1194085001952	H-loop/switch region; other site
1194085001953	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1194085001954	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1194085001955	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1194085001956	Walker A/P-loop; other site
1194085001957	ATP binding site [chemical binding]; other site
1194085001958	Q-loop/lid; other site
1194085001959	ABC transporter signature motif; other site
1194085001960	Walker B; other site
1194085001961	D-loop; other site
1194085001962	H-loop/switch region; other site
1194085001963	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1194085001964	MarR family; Region: MarR; pfam01047
1194085001965	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1194085001966	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1194085001967	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1194085001968	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1194085001969	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1194085001970	active site
1194085001971	catalytic tetrad [active]
1194085001972	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1194085001973	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1194085001974	transmembrane helices; other site
1194085001975	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1194085001976	DNA photolyase; Region: DNA_photolyase; pfam00875
1194085001977	Predicted membrane protein [Function unknown]; Region: COG4330
1194085001978	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
1194085001979	trimer interface [polypeptide binding]; other site
1194085001980	putative Zn binding site [ion binding]; other site
1194085001981	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1194085001982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085001983	putative substrate translocation pore; other site
1194085001984	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1194085001985	putative deacylase active site [active]
1194085001986	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1194085001987	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1194085001988	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1194085001989	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1194085001990	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1194085001991	putative substrate binding site [chemical binding]; other site
1194085001992	putative ATP binding site [chemical binding]; other site
1194085001993	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1194085001994	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1194085001995	active site
1194085001996	phosphorylation site [posttranslational modification]
1194085001997	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1194085001998	active site
1194085001999	P-loop; other site
1194085002000	phosphorylation site [posttranslational modification]
1194085002001	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1194085002002	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1194085002003	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1194085002004	active site
1194085002005	dimer interface [polypeptide binding]; other site
1194085002006	Domain of unknown function DUF21; Region: DUF21; pfam01595
1194085002007	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1194085002008	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1194085002009	Transporter associated domain; Region: CorC_HlyC; pfam03471
1194085002010	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1194085002011	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1194085002012	active site
1194085002013	catalytic tetrad [active]
1194085002014	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1194085002015	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1194085002016	Ligand binding site; other site
1194085002017	Putative Catalytic site; other site
1194085002018	DXD motif; other site
1194085002019	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1194085002020	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1194085002021	dimer interface [polypeptide binding]; other site
1194085002022	phosphorylation site [posttranslational modification]
1194085002023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085002024	ATP binding site [chemical binding]; other site
1194085002025	Mg2+ binding site [ion binding]; other site
1194085002026	G-X-G motif; other site
1194085002027	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1194085002028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085002029	active site
1194085002030	phosphorylation site [posttranslational modification]
1194085002031	intermolecular recognition site; other site
1194085002032	dimerization interface [polypeptide binding]; other site
1194085002033	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1194085002034	DNA binding site [nucleotide binding]
1194085002035	DoxX; Region: DoxX; pfam07681
1194085002036	Electron transfer DM13; Region: DM13; pfam10517
1194085002037	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1194085002038	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1194085002039	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
1194085002040	active site
1194085002041	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1194085002042	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1194085002043	Ligand Binding Site [chemical binding]; other site
1194085002044	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1194085002045	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1194085002046	glutamine binding [chemical binding]; other site
1194085002047	catalytic triad [active]
1194085002048	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1194085002049	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1194085002050	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1194085002051	substrate-cofactor binding pocket; other site
1194085002052	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1194085002053	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085002054	catalytic residue [active]
1194085002055	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1194085002056	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1194085002057	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1194085002058	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1194085002059	Sulfatase; Region: Sulfatase; pfam00884
1194085002060	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1194085002061	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1194085002062	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1194085002063	ABC transporter; Region: ABC_tran_2; pfam12848
1194085002064	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1194085002065	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1194085002066	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1194085002067	ATP binding site [chemical binding]; other site
1194085002068	putative Mg++ binding site [ion binding]; other site
1194085002069	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1194085002070	nucleotide binding region [chemical binding]; other site
1194085002071	ATP-binding site [chemical binding]; other site
1194085002072	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1194085002073	HRDC domain; Region: HRDC; pfam00570
1194085002074	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1194085002075	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1194085002076	Walker A/P-loop; other site
1194085002077	ATP binding site [chemical binding]; other site
1194085002078	Q-loop/lid; other site
1194085002079	ABC transporter signature motif; other site
1194085002080	Walker B; other site
1194085002081	D-loop; other site
1194085002082	H-loop/switch region; other site
1194085002083	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1194085002084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085002085	dimer interface [polypeptide binding]; other site
1194085002086	conserved gate region; other site
1194085002087	ABC-ATPase subunit interface; other site
1194085002088	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1194085002089	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1194085002090	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1194085002091	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1194085002092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085002093	homodimer interface [polypeptide binding]; other site
1194085002094	catalytic residue [active]
1194085002095	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
1194085002096	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1194085002097	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1194085002098	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1194085002099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085002100	putative substrate translocation pore; other site
1194085002101	POT family; Region: PTR2; cl17359
1194085002102	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1194085002103	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1194085002104	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
1194085002105	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
1194085002106	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1194085002107	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1194085002108	active site
1194085002109	dimer interface [polypeptide binding]; other site
1194085002110	catalytic residues [active]
1194085002111	effector binding site; other site
1194085002112	R2 peptide binding site; other site
1194085002113	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1194085002114	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1194085002115	dimer interface [polypeptide binding]; other site
1194085002116	putative radical transfer pathway; other site
1194085002117	diiron center [ion binding]; other site
1194085002118	tyrosyl radical; other site
1194085002119	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085002120	ABC-ATPase subunit  interface; other site
1194085002121	dimer interface [polypeptide binding]; other site
1194085002122	putative PBP binding regions; other site
1194085002123	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085002124	ABC-ATPase subunit  interface; other site
1194085002125	dimer interface [polypeptide binding]; other site
1194085002126	putative PBP binding regions; other site
1194085002127	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1194085002128	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1194085002129	Walker A/P-loop; other site
1194085002130	ATP binding site [chemical binding]; other site
1194085002131	Q-loop/lid; other site
1194085002132	ABC transporter signature motif; other site
1194085002133	Walker B; other site
1194085002134	D-loop; other site
1194085002135	H-loop/switch region; other site
1194085002136	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1194085002137	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1194085002138	putative ligand binding residues [chemical binding]; other site
1194085002139	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
1194085002140	FAD binding domain; Region: FAD_binding_4; pfam01565
1194085002141	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1194085002142	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1194085002143	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
1194085002144	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1194085002145	peptidase T; Region: peptidase-T; TIGR01882
1194085002146	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1194085002147	metal binding site [ion binding]; metal-binding site
1194085002148	dimer interface [polypeptide binding]; other site
1194085002149	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1194085002150	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1194085002151	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1194085002152	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1194085002153	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1194085002154	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1194085002155	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1194085002156	metal binding site [ion binding]; metal-binding site
1194085002157	active site
1194085002158	I-site; other site
1194085002159	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1194085002160	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1194085002161	Mg++ binding site [ion binding]; other site
1194085002162	putative catalytic motif [active]
1194085002163	substrate binding site [chemical binding]; other site
1194085002164	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1194085002165	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1194085002166	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1194085002167	EDD domain protein, DegV family; Region: DegV; TIGR00762
1194085002168	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1194085002169	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1194085002170	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1194085002171	ATP binding site [chemical binding]; other site
1194085002172	putative Mg++ binding site [ion binding]; other site
1194085002173	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1194085002174	nucleotide binding region [chemical binding]; other site
1194085002175	ATP-binding site [chemical binding]; other site
1194085002176	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1194085002177	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1194085002178	active site
1194085002179	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1194085002180	30S subunit binding site; other site
1194085002181	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1194085002182	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1194085002183	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1194085002184	nucleotide binding region [chemical binding]; other site
1194085002185	ATP-binding site [chemical binding]; other site
1194085002186	SEC-C motif; Region: SEC-C; pfam02810
1194085002187	peptide chain release factor 2; Provisional; Region: PRK06746
1194085002188	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1194085002189	RF-1 domain; Region: RF-1; pfam00472
1194085002190	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1194085002191	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1194085002192	Surface antigen [General function prediction only]; Region: COG3942
1194085002193	CHAP domain; Region: CHAP; pfam05257
1194085002194	HD domain; Region: HD_3; cl17350
1194085002195	Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559
1194085002196	excinuclease ABC subunit B; Provisional; Region: PRK05298
1194085002197	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1194085002198	ATP binding site [chemical binding]; other site
1194085002199	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1194085002200	nucleotide binding region [chemical binding]; other site
1194085002201	ATP-binding site [chemical binding]; other site
1194085002202	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1194085002203	UvrB/uvrC motif; Region: UVR; pfam02151
1194085002204	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1194085002205	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1194085002206	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1194085002207	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1194085002208	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1194085002209	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1194085002210	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1194085002211	Hpr binding site; other site
1194085002212	active site
1194085002213	homohexamer subunit interaction site [polypeptide binding]; other site
1194085002214	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1194085002215	putative acyl transferase; Provisional; Region: PRK10191
1194085002216	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1194085002217	trimer interface [polypeptide binding]; other site
1194085002218	active site
1194085002219	substrate binding site [chemical binding]; other site
1194085002220	CoA binding site [chemical binding]; other site
1194085002221	TPR repeat; Region: TPR_11; pfam13414
1194085002222	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1194085002223	binding surface
1194085002224	TPR motif; other site
1194085002225	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1194085002226	TPR motif; other site
1194085002227	binding surface
1194085002228	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1194085002229	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1194085002230	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085002231	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
1194085002232	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1194085002233	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
1194085002234	phosphate binding site [ion binding]; other site
1194085002235	dimer interface [polypeptide binding]; other site
1194085002236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1194085002237	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1194085002238	Clp protease; Region: CLP_protease; pfam00574
1194085002239	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1194085002240	oligomer interface [polypeptide binding]; other site
1194085002241	active site residues [active]
1194085002242	malate dehydrogenase; Provisional; Region: PRK13529
1194085002243	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1194085002244	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1194085002245	NAD(P) binding site [chemical binding]; other site
1194085002246	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1194085002247	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1194085002248	NAD(P) binding site [chemical binding]; other site
1194085002249	active site
1194085002250	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1194085002251	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1194085002252	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1194085002253	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1194085002254	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1194085002255	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1194085002256	Phosphoglycerate kinase; Region: PGK; pfam00162
1194085002257	substrate binding site [chemical binding]; other site
1194085002258	hinge regions; other site
1194085002259	ADP binding site [chemical binding]; other site
1194085002260	catalytic site [active]
1194085002261	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1194085002262	triosephosphate isomerase; Provisional; Region: PRK14565
1194085002263	substrate binding site [chemical binding]; other site
1194085002264	dimer interface [polypeptide binding]; other site
1194085002265	catalytic triad [active]
1194085002266	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1194085002267	phosphoglyceromutase; Provisional; Region: PRK05434
1194085002268	enolase; Provisional; Region: eno; PRK00077
1194085002269	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1194085002270	dimer interface [polypeptide binding]; other site
1194085002271	metal binding site [ion binding]; metal-binding site
1194085002272	substrate binding pocket [chemical binding]; other site
1194085002273	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1194085002274	Esterase/lipase [General function prediction only]; Region: COG1647
1194085002275	ribonuclease R; Region: RNase_R; TIGR02063
1194085002276	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1194085002277	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1194085002278	RNB domain; Region: RNB; pfam00773
1194085002279	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1194085002280	RNA binding site [nucleotide binding]; other site
1194085002281	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1194085002282	SmpB-tmRNA interface; other site
1194085002283	Integral membrane protein DUF95; Region: DUF95; cl00572
1194085002284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085002285	Coenzyme A binding pocket [chemical binding]; other site
1194085002286	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1194085002287	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1194085002288	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1194085002289	Staphylococcal nuclease homologues; Region: SNc; smart00318
1194085002290	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1194085002291	Catalytic site; other site
1194085002292	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1194085002293	DNA-binding site [nucleotide binding]; DNA binding site
1194085002294	RNA-binding motif; other site
1194085002295	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
1194085002296	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1194085002297	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1194085002298	catalytic core [active]
1194085002299	Lysine efflux permease [General function prediction only]; Region: COG1279
1194085002300	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1194085002301	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1194085002302	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1194085002303	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1194085002304	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1194085002305	active site
1194085002306	catalytic residue [active]
1194085002307	dimer interface [polypeptide binding]; other site
1194085002308	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1194085002309	putative FMN binding site [chemical binding]; other site
1194085002310	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1194085002311	catalytic residues [active]
1194085002312	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1194085002313	ArsC family; Region: ArsC; pfam03960
1194085002314	putative ArsC-like catalytic residues; other site
1194085002315	putative TRX-like catalytic residues [active]
1194085002316	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1194085002317	lipoyl attachment site [posttranslational modification]; other site
1194085002318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
1194085002319	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1194085002320	putative active site [active]
1194085002321	putative metal binding site [ion binding]; other site
1194085002322	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1194085002323	catalytic residues [active]
1194085002324	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1194085002325	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1194085002326	Walker A/P-loop; other site
1194085002327	ATP binding site [chemical binding]; other site
1194085002328	Q-loop/lid; other site
1194085002329	ABC transporter signature motif; other site
1194085002330	Walker B; other site
1194085002331	D-loop; other site
1194085002332	H-loop/switch region; other site
1194085002333	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1194085002334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085002335	dimer interface [polypeptide binding]; other site
1194085002336	conserved gate region; other site
1194085002337	ABC-ATPase subunit interface; other site
1194085002338	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1194085002339	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1194085002340	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1194085002341	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
1194085002342	Int/Topo IB signature motif; other site
1194085002343	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1194085002344	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085002345	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1194085002346	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085002347	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1194085002348	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1194085002349	non-specific DNA binding site [nucleotide binding]; other site
1194085002350	salt bridge; other site
1194085002351	sequence-specific DNA binding site [nucleotide binding]; other site
1194085002352	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1194085002353	non-specific DNA binding site [nucleotide binding]; other site
1194085002354	salt bridge; other site
1194085002355	sequence-specific DNA binding site [nucleotide binding]; other site
1194085002356	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1194085002357	Protein of unknown function (DUF1474); Region: DUF1474; pfam07342
1194085002358	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
1194085002359	Virulence-associated protein E; Region: VirE; pfam05272
1194085002360	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1194085002361	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
1194085002362	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1194085002363	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085002364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1194085002365	Predicted membrane protein [Function unknown]; Region: COG2035
1194085002366	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1194085002367	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1194085002368	Walker A/P-loop; other site
1194085002369	ATP binding site [chemical binding]; other site
1194085002370	Q-loop/lid; other site
1194085002371	ABC transporter signature motif; other site
1194085002372	Walker B; other site
1194085002373	D-loop; other site
1194085002374	H-loop/switch region; other site
1194085002375	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1194085002376	FeS assembly protein SufD; Region: sufD; TIGR01981
1194085002377	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1194085002378	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1194085002379	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1194085002380	catalytic residue [active]
1194085002381	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1194085002382	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1194085002383	trimerization site [polypeptide binding]; other site
1194085002384	active site
1194085002385	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1194085002386	FeS assembly protein SufB; Region: sufB; TIGR01980
1194085002387	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1194085002388	Domain of unknown function DUF21; Region: DUF21; pfam01595
1194085002389	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1194085002390	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1194085002391	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1194085002392	FMN binding site [chemical binding]; other site
1194085002393	substrate binding site [chemical binding]; other site
1194085002394	putative catalytic residue [active]
1194085002395	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1194085002396	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1194085002397	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1194085002398	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1194085002399	active site
1194085002400	metal binding site [ion binding]; metal-binding site
1194085002401	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1194085002402	lipoyl synthase; Provisional; Region: PRK05481
1194085002403	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085002404	FeS/SAM binding site; other site
1194085002405	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
1194085002406	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1194085002407	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1194085002408	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1194085002409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085002410	active site
1194085002411	motif I; other site
1194085002412	motif II; other site
1194085002413	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085002414	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1194085002415	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1194085002416	dimerization interface [polypeptide binding]; other site
1194085002417	ligand binding site [chemical binding]; other site
1194085002418	NADP binding site [chemical binding]; other site
1194085002419	catalytic site [active]
1194085002420	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
1194085002421	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1194085002422	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1194085002423	acyl-activating enzyme (AAE) consensus motif; other site
1194085002424	AMP binding site [chemical binding]; other site
1194085002425	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1194085002426	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1194085002427	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1194085002428	DltD N-terminal region; Region: DltD_N; pfam04915
1194085002429	DltD central region; Region: DltD_M; pfam04918
1194085002430	DltD C-terminal region; Region: DltD_C; pfam04914
1194085002431	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1194085002432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
1194085002433	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1194085002434	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085002435	hypothetical protein; Provisional; Region: PRK13669
1194085002436	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1194085002437	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1194085002438	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085002439	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
1194085002440	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1194085002441	interface (dimer of trimers) [polypeptide binding]; other site
1194085002442	Substrate-binding/catalytic site; other site
1194085002443	Zn-binding sites [ion binding]; other site
1194085002444	Predicted permease [General function prediction only]; Region: COG2056
1194085002445	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1194085002446	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1194085002447	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1194085002448	CoenzymeA binding site [chemical binding]; other site
1194085002449	subunit interaction site [polypeptide binding]; other site
1194085002450	PHB binding site; other site
1194085002451	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1194085002452	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1194085002453	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
1194085002454	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
1194085002455	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
1194085002456	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
1194085002457	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1194085002458	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
1194085002459	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
1194085002460	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
1194085002461	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1194085002462	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1194085002463	Kinase associated protein B; Region: KapB; pfam08810
1194085002464	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1194085002465	active site
1194085002466	general stress protein 13; Validated; Region: PRK08059
1194085002467	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1194085002468	RNA binding site [nucleotide binding]; other site
1194085002469	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1194085002470	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1194085002471	putative active site [active]
1194085002472	putative FMN binding site [chemical binding]; other site
1194085002473	putative substrate binding site [chemical binding]; other site
1194085002474	putative catalytic residue [active]
1194085002475	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1194085002476	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1194085002477	inhibitor-cofactor binding pocket; inhibition site
1194085002478	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085002479	catalytic residue [active]
1194085002480	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1194085002481	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1194085002482	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1194085002483	NAD(P) binding site [chemical binding]; other site
1194085002484	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1194085002485	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1194085002486	active site
1194085002487	catalytic site [active]
1194085002488	metal binding site [ion binding]; metal-binding site
1194085002489	argininosuccinate lyase; Provisional; Region: PRK00855
1194085002490	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1194085002491	active sites [active]
1194085002492	tetramer interface [polypeptide binding]; other site
1194085002493	argininosuccinate synthase; Provisional; Region: PRK13820
1194085002494	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1194085002495	ANP binding site [chemical binding]; other site
1194085002496	Substrate Binding Site II [chemical binding]; other site
1194085002497	Substrate Binding Site I [chemical binding]; other site
1194085002498	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1194085002499	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1194085002500	active site
1194085002501	dimer interface [polypeptide binding]; other site
1194085002502	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1194085002503	dimer interface [polypeptide binding]; other site
1194085002504	active site
1194085002505	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1194085002506	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1194085002507	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1194085002508	Catalytic site [active]
1194085002509	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1194085002510	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1194085002511	Catalytic site [active]
1194085002512	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1194085002513	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1194085002514	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1194085002515	Part of AAA domain; Region: AAA_19; pfam13245
1194085002516	Family description; Region: UvrD_C_2; pfam13538
1194085002517	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1194085002518	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1194085002519	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1194085002520	hypothetical protein; Provisional; Region: PRK13673
1194085002521	coenzyme A disulfide reductase; Provisional; Region: PRK13512
1194085002522	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1194085002523	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085002524	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1194085002525	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1194085002526	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085002527	active site
1194085002528	motif I; other site
1194085002529	motif II; other site
1194085002530	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085002531	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1194085002532	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1194085002533	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1194085002534	catalytic triad [active]
1194085002535	catalytic triad [active]
1194085002536	oxyanion hole [active]
1194085002537	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1194085002538	Clp amino terminal domain; Region: Clp_N; pfam02861
1194085002539	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085002540	Walker A motif; other site
1194085002541	ATP binding site [chemical binding]; other site
1194085002542	Walker B motif; other site
1194085002543	arginine finger; other site
1194085002544	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1194085002545	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085002546	Walker A motif; other site
1194085002547	ATP binding site [chemical binding]; other site
1194085002548	Walker B motif; other site
1194085002549	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1194085002550	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1194085002551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1194085002552	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1194085002553	dimerization interface [polypeptide binding]; other site
1194085002554	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1194085002555	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1194085002556	active site
1194085002557	catalytic residues [active]
1194085002558	metal binding site [ion binding]; metal-binding site
1194085002559	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1194085002560	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1194085002561	substrate binding site [chemical binding]; other site
1194085002562	MAP domain; Region: MAP; pfam03642
1194085002563	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1194085002564	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1194085002565	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1194085002566	dimer interface [polypeptide binding]; other site
1194085002567	active site
1194085002568	CoA binding pocket [chemical binding]; other site
1194085002569	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1194085002570	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1194085002571	dimer interface [polypeptide binding]; other site
1194085002572	active site
1194085002573	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
1194085002574	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1194085002575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085002576	dimer interface [polypeptide binding]; other site
1194085002577	conserved gate region; other site
1194085002578	putative PBP binding loops; other site
1194085002579	ABC-ATPase subunit interface; other site
1194085002580	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1194085002581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085002582	dimer interface [polypeptide binding]; other site
1194085002583	conserved gate region; other site
1194085002584	putative PBP binding loops; other site
1194085002585	ABC-ATPase subunit interface; other site
1194085002586	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1194085002587	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085002588	Walker A/P-loop; other site
1194085002589	ATP binding site [chemical binding]; other site
1194085002590	Q-loop/lid; other site
1194085002591	ABC transporter signature motif; other site
1194085002592	Walker B; other site
1194085002593	D-loop; other site
1194085002594	H-loop/switch region; other site
1194085002595	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1194085002596	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1194085002597	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085002598	Walker A/P-loop; other site
1194085002599	ATP binding site [chemical binding]; other site
1194085002600	Q-loop/lid; other site
1194085002601	ABC transporter signature motif; other site
1194085002602	Walker B; other site
1194085002603	D-loop; other site
1194085002604	H-loop/switch region; other site
1194085002605	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1194085002606	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1194085002607	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1194085002608	peptide binding site [polypeptide binding]; other site
1194085002609	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1194085002610	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
1194085002611	peptide binding site [polypeptide binding]; other site
1194085002612	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1194085002613	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085002614	Walker A/P-loop; other site
1194085002615	ATP binding site [chemical binding]; other site
1194085002616	Q-loop/lid; other site
1194085002617	ABC transporter signature motif; other site
1194085002618	Walker B; other site
1194085002619	D-loop; other site
1194085002620	H-loop/switch region; other site
1194085002621	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1194085002622	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1194085002623	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085002624	Walker A/P-loop; other site
1194085002625	ATP binding site [chemical binding]; other site
1194085002626	Q-loop/lid; other site
1194085002627	ABC transporter signature motif; other site
1194085002628	Walker B; other site
1194085002629	D-loop; other site
1194085002630	H-loop/switch region; other site
1194085002631	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1194085002632	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1194085002633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085002634	dimer interface [polypeptide binding]; other site
1194085002635	conserved gate region; other site
1194085002636	putative PBP binding loops; other site
1194085002637	ABC-ATPase subunit interface; other site
1194085002638	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1194085002639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085002640	dimer interface [polypeptide binding]; other site
1194085002641	conserved gate region; other site
1194085002642	putative PBP binding loops; other site
1194085002643	ABC-ATPase subunit interface; other site
1194085002644	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085002645	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085002646	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1194085002647	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085002648	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1194085002649	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1194085002650	active site
1194085002651	HIGH motif; other site
1194085002652	dimer interface [polypeptide binding]; other site
1194085002653	KMSKS motif; other site
1194085002654	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1194085002655	ArsC family; Region: ArsC; pfam03960
1194085002656	putative catalytic residues [active]
1194085002657	thiol/disulfide switch; other site
1194085002658	adaptor protein; Provisional; Region: PRK02315
1194085002659	Competence protein CoiA-like family; Region: CoiA; cl11541
1194085002660	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1194085002661	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1194085002662	active site
1194085002663	Zn binding site [ion binding]; other site
1194085002664	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1194085002665	Thioredoxin; Region: Thioredoxin_5; pfam13743
1194085002666	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1194085002667	apolar tunnel; other site
1194085002668	heme binding site [chemical binding]; other site
1194085002669	dimerization interface [polypeptide binding]; other site
1194085002670	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1194085002671	putative active site [active]
1194085002672	putative metal binding residues [ion binding]; other site
1194085002673	signature motif; other site
1194085002674	putative triphosphate binding site [ion binding]; other site
1194085002675	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1194085002676	synthetase active site [active]
1194085002677	NTP binding site [chemical binding]; other site
1194085002678	metal binding site [ion binding]; metal-binding site
1194085002679	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1194085002680	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1194085002681	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1194085002682	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1194085002683	active site
1194085002684	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1194085002685	MgtE intracellular N domain; Region: MgtE_N; smart00924
1194085002686	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1194085002687	Divalent cation transporter; Region: MgtE; pfam01769
1194085002688	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1194085002689	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1194085002690	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1194085002691	TrkA-N domain; Region: TrkA_N; pfam02254
1194085002692	TrkA-C domain; Region: TrkA_C; pfam02080
1194085002693	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1194085002694	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1194085002695	NAD binding site [chemical binding]; other site
1194085002696	homotetramer interface [polypeptide binding]; other site
1194085002697	homodimer interface [polypeptide binding]; other site
1194085002698	substrate binding site [chemical binding]; other site
1194085002699	active site
1194085002700	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1194085002701	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1194085002702	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1194085002703	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1194085002704	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1194085002705	Putative esterase; Region: Esterase; pfam00756
1194085002706	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1194085002707	minor groove reading motif; other site
1194085002708	helix-hairpin-helix signature motif; other site
1194085002709	substrate binding pocket [chemical binding]; other site
1194085002710	active site
1194085002711	hypothetical protein; Provisional; Region: PRK13679
1194085002712	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1194085002713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085002714	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085002715	putative substrate translocation pore; other site
1194085002716	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
1194085002717	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1194085002718	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1194085002719	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1194085002720	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1194085002721	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1194085002722	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1194085002723	YueH-like protein; Region: YueH; pfam14166
1194085002724	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1194085002725	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1194085002726	G1 box; other site
1194085002727	putative GEF interaction site [polypeptide binding]; other site
1194085002728	GTP/Mg2+ binding site [chemical binding]; other site
1194085002729	Switch I region; other site
1194085002730	G2 box; other site
1194085002731	G3 box; other site
1194085002732	Switch II region; other site
1194085002733	G4 box; other site
1194085002734	G5 box; other site
1194085002735	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1194085002736	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1194085002737	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1194085002738	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1194085002739	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1194085002740	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1194085002741	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1194085002742	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1194085002743	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1194085002744	active site
1194085002745	metal binding site [ion binding]; metal-binding site
1194085002746	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1194085002747	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
1194085002748	IDEAL domain; Region: IDEAL; pfam08858
1194085002749	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1194085002750	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1194085002751	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1194085002752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
1194085002753	CAAX protease self-immunity; Region: Abi; pfam02517
1194085002754	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085002755	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085002756	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1194085002757	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085002758	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
1194085002759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
1194085002760	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
1194085002761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1194085002762	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1194085002763	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1194085002764	Walker A/P-loop; other site
1194085002765	ATP binding site [chemical binding]; other site
1194085002766	Q-loop/lid; other site
1194085002767	ABC transporter signature motif; other site
1194085002768	Walker B; other site
1194085002769	D-loop; other site
1194085002770	H-loop/switch region; other site
1194085002771	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1194085002772	Predicted membrane protein [Function unknown]; Region: COG2259
1194085002773	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1194085002774	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1194085002775	siderophore binding site; other site
1194085002776	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1194085002777	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085002778	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1194085002779	Coenzyme A binding pocket [chemical binding]; other site
1194085002780	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1194085002781	UbiA prenyltransferase family; Region: UbiA; pfam01040
1194085002782	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1194085002783	isochorismate synthases; Region: isochor_syn; TIGR00543
1194085002784	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1194085002785	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1194085002786	dimer interface [polypeptide binding]; other site
1194085002787	tetramer interface [polypeptide binding]; other site
1194085002788	PYR/PP interface [polypeptide binding]; other site
1194085002789	TPP binding site [chemical binding]; other site
1194085002790	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1194085002791	TPP-binding site; other site
1194085002792	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1194085002793	PGAP1-like protein; Region: PGAP1; pfam07819
1194085002794	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1194085002795	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1194085002796	substrate binding site [chemical binding]; other site
1194085002797	oxyanion hole (OAH) forming residues; other site
1194085002798	trimer interface [polypeptide binding]; other site
1194085002799	Staphostatin B; Region: Staphostatin_B; pfam09023
1194085002800	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1194085002801	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1194085002802	aminotransferase A; Validated; Region: PRK07683
1194085002803	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1194085002804	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085002805	homodimer interface [polypeptide binding]; other site
1194085002806	catalytic residue [active]
1194085002807	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1194085002808	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1194085002809	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1194085002810	MarR family; Region: MarR; pfam01047
1194085002811	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1194085002812	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1194085002813	amidase catalytic site [active]
1194085002814	Zn binding residues [ion binding]; other site
1194085002815	substrate binding site [chemical binding]; other site
1194085002816	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1194085002817	Lysozyme subfamily 2; Region: LYZ2; smart00047
1194085002818	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085002819	Coenzyme A binding pocket [chemical binding]; other site
1194085002820	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
1194085002821	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1194085002822	Beta-lactamase; Region: Beta-lactamase; pfam00144
1194085002823	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1194085002824	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
1194085002825	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1194085002826	Subunit I/III interface [polypeptide binding]; other site
1194085002827	Subunit III/IV interface [polypeptide binding]; other site
1194085002828	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1194085002829	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1194085002830	D-pathway; other site
1194085002831	Putative ubiquinol binding site [chemical binding]; other site
1194085002832	Low-spin heme (heme b) binding site [chemical binding]; other site
1194085002833	Putative water exit pathway; other site
1194085002834	Binuclear center (heme o3/CuB) [ion binding]; other site
1194085002835	K-pathway; other site
1194085002836	Putative proton exit pathway; other site
1194085002837	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1194085002838	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1194085002839	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1194085002840	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1194085002841	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
1194085002842	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1194085002843	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1194085002844	homodimer interface [polypeptide binding]; other site
1194085002845	NADP binding site [chemical binding]; other site
1194085002846	substrate binding site [chemical binding]; other site
1194085002847	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1194085002848	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1194085002849	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1194085002850	NAD binding site [chemical binding]; other site
1194085002851	ATP-grasp domain; Region: ATP-grasp; pfam02222
1194085002852	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1194085002853	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1194085002854	ATP binding site [chemical binding]; other site
1194085002855	active site
1194085002856	substrate binding site [chemical binding]; other site
1194085002857	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
1194085002858	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1194085002859	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1194085002860	putative active site [active]
1194085002861	catalytic triad [active]
1194085002862	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1194085002863	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1194085002864	dimerization interface [polypeptide binding]; other site
1194085002865	ATP binding site [chemical binding]; other site
1194085002866	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1194085002867	dimerization interface [polypeptide binding]; other site
1194085002868	ATP binding site [chemical binding]; other site
1194085002869	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1194085002870	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1194085002871	active site
1194085002872	tetramer interface [polypeptide binding]; other site
1194085002873	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1194085002874	active site
1194085002875	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1194085002876	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1194085002877	dimerization interface [polypeptide binding]; other site
1194085002878	putative ATP binding site [chemical binding]; other site
1194085002879	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
1194085002880	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1194085002881	active site
1194085002882	substrate binding site [chemical binding]; other site
1194085002883	cosubstrate binding site; other site
1194085002884	catalytic site [active]
1194085002885	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1194085002886	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1194085002887	purine monophosphate binding site [chemical binding]; other site
1194085002888	dimer interface [polypeptide binding]; other site
1194085002889	putative catalytic residues [active]
1194085002890	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1194085002891	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1194085002892	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1194085002893	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
1194085002894	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1194085002895	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1194085002896	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1194085002897	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1194085002898	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1194085002899	Walker A/P-loop; other site
1194085002900	ATP binding site [chemical binding]; other site
1194085002901	Q-loop/lid; other site
1194085002902	ABC transporter signature motif; other site
1194085002903	Walker B; other site
1194085002904	D-loop; other site
1194085002905	H-loop/switch region; other site
1194085002906	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
1194085002907	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1194085002908	Walker A/P-loop; other site
1194085002909	ATP binding site [chemical binding]; other site
1194085002910	Q-loop/lid; other site
1194085002911	ABC transporter signature motif; other site
1194085002912	Walker B; other site
1194085002913	D-loop; other site
1194085002914	H-loop/switch region; other site
1194085002915	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
1194085002916	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1194085002917	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1194085002918	putative RNA binding site [nucleotide binding]; other site
1194085002919	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1194085002920	Domain of unknown function (DUF697); Region: DUF697; cl12064
1194085002921	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1194085002922	dimerization domain swap beta strand [polypeptide binding]; other site
1194085002923	regulatory protein interface [polypeptide binding]; other site
1194085002924	active site
1194085002925	regulatory phosphorylation site [posttranslational modification]; other site
1194085002926	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1194085002927	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1194085002928	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1194085002929	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1194085002930	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1194085002931	catalytic residues [active]
1194085002932	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1194085002933	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1194085002934	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1194085002935	TrkA-N domain; Region: TrkA_N; pfam02254
1194085002936	TrkA-C domain; Region: TrkA_C; pfam02080
1194085002937	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1194085002938	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1194085002939	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1194085002940	hypothetical protein; Provisional; Region: PRK13667
1194085002941	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1194085002942	active site
1194085002943	catalytic residues [active]
1194085002944	metal binding site [ion binding]; metal-binding site
1194085002945	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1194085002946	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1194085002947	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1194085002948	TPP-binding site [chemical binding]; other site
1194085002949	tetramer interface [polypeptide binding]; other site
1194085002950	heterodimer interface [polypeptide binding]; other site
1194085002951	phosphorylation loop region [posttranslational modification]
1194085002952	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1194085002953	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1194085002954	alpha subunit interface [polypeptide binding]; other site
1194085002955	TPP binding site [chemical binding]; other site
1194085002956	heterodimer interface [polypeptide binding]; other site
1194085002957	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1194085002958	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1194085002959	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1194085002960	E3 interaction surface; other site
1194085002961	lipoyl attachment site [posttranslational modification]; other site
1194085002962	e3 binding domain; Region: E3_binding; pfam02817
1194085002963	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1194085002964	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1194085002965	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1194085002966	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085002967	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1194085002968	hypothetical protein; Provisional; Region: PRK04387
1194085002969	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1194085002970	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1194085002971	non-specific DNA binding site [nucleotide binding]; other site
1194085002972	salt bridge; other site
1194085002973	sequence-specific DNA binding site [nucleotide binding]; other site
1194085002974	Cupin domain; Region: Cupin_2; pfam07883
1194085002975	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1194085002976	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085002977	Walker A/P-loop; other site
1194085002978	ATP binding site [chemical binding]; other site
1194085002979	Q-loop/lid; other site
1194085002980	ABC transporter signature motif; other site
1194085002981	Walker B; other site
1194085002982	D-loop; other site
1194085002983	H-loop/switch region; other site
1194085002984	TOBE domain; Region: TOBE_2; pfam08402
1194085002985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085002986	putative PBP binding loops; other site
1194085002987	dimer interface [polypeptide binding]; other site
1194085002988	ABC-ATPase subunit interface; other site
1194085002989	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1194085002990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085002991	dimer interface [polypeptide binding]; other site
1194085002992	conserved gate region; other site
1194085002993	putative PBP binding loops; other site
1194085002994	ABC-ATPase subunit interface; other site
1194085002995	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1194085002996	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
1194085002997	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1194085002998	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1194085002999	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1194085003000	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1194085003001	manganese transport protein MntH; Reviewed; Region: PRK00701
1194085003002	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1194085003003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1194085003004	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1194085003005	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1194085003006	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1194085003007	active site
1194085003008	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1194085003009	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1194085003010	G1 box; other site
1194085003011	putative GEF interaction site [polypeptide binding]; other site
1194085003012	GTP/Mg2+ binding site [chemical binding]; other site
1194085003013	Switch I region; other site
1194085003014	G2 box; other site
1194085003015	G3 box; other site
1194085003016	Switch II region; other site
1194085003017	G4 box; other site
1194085003018	G5 box; other site
1194085003019	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1194085003020	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1194085003021	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
1194085003022	hypothetical protein; Provisional; Region: PRK13666
1194085003023	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1194085003024	pyruvate carboxylase; Reviewed; Region: PRK12999
1194085003025	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1194085003026	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1194085003027	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1194085003028	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1194085003029	active site
1194085003030	catalytic residues [active]
1194085003031	metal binding site [ion binding]; metal-binding site
1194085003032	homodimer binding site [polypeptide binding]; other site
1194085003033	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1194085003034	carboxyltransferase (CT) interaction site; other site
1194085003035	biotinylation site [posttranslational modification]; other site
1194085003036	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1194085003037	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1194085003038	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1194085003039	UbiA prenyltransferase family; Region: UbiA; pfam01040
1194085003040	Predicted membrane protein [Function unknown]; Region: COG2322
1194085003041	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1194085003042	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1194085003043	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
1194085003044	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1194085003045	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1194085003046	putative active site [active]
1194085003047	catalytic site [active]
1194085003048	putative metal binding site [ion binding]; other site
1194085003049	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471
1194085003050	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1194085003051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085003052	S-adenosylmethionine binding site [chemical binding]; other site
1194085003053	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1194085003054	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1194085003055	active site
1194085003056	(T/H)XGH motif; other site
1194085003057	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
1194085003058	hypothetical protein; Provisional; Region: PRK13670
1194085003059	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1194085003060	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1194085003061	heme uptake protein IsdB; Region: IsdB; TIGR03657
1194085003062	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1194085003063	NEAr Transporter domain; Region: NEAT; smart00725
1194085003064	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1194085003065	heme-binding site [chemical binding]; other site
1194085003066	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1194085003067	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
1194085003068	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1194085003069	heme-binding site [chemical binding]; other site
1194085003070	heme uptake protein IsdC; Region: IsdC; TIGR03656
1194085003071	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1194085003072	heme-binding site [chemical binding]; other site
1194085003073	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
1194085003074	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1194085003075	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1194085003076	intersubunit interface [polypeptide binding]; other site
1194085003077	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1194085003078	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085003079	ABC-ATPase subunit  interface; other site
1194085003080	dimer interface [polypeptide binding]; other site
1194085003081	putative PBP binding regions; other site
1194085003082	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1194085003083	active site
1194085003084	catalytic site [active]
1194085003085	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312
1194085003086	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1194085003087	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1194085003088	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1194085003089	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1194085003090	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1194085003091	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1194085003092	dimer interface [polypeptide binding]; other site
1194085003093	motif 1; other site
1194085003094	active site
1194085003095	motif 2; other site
1194085003096	motif 3; other site
1194085003097	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1194085003098	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1194085003099	putative tRNA-binding site [nucleotide binding]; other site
1194085003100	B3/4 domain; Region: B3_4; pfam03483
1194085003101	tRNA synthetase B5 domain; Region: B5; smart00874
1194085003102	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1194085003103	dimer interface [polypeptide binding]; other site
1194085003104	motif 1; other site
1194085003105	motif 3; other site
1194085003106	motif 2; other site
1194085003107	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1194085003108	ribonuclease HIII; Provisional; Region: PRK00996
1194085003109	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1194085003110	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1194085003111	RNA/DNA hybrid binding site [nucleotide binding]; other site
1194085003112	active site
1194085003113	Cell division protein ZapA; Region: ZapA; cl01146
1194085003114	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1194085003115	Colicin V production protein; Region: Colicin_V; pfam02674
1194085003116	hypothetical protein; Provisional; Region: PRK08609
1194085003117	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1194085003118	active site
1194085003119	primer binding site [nucleotide binding]; other site
1194085003120	NTP  binding site [chemical binding]; other site
1194085003121	metal binding triad [ion binding]; metal-binding site
1194085003122	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1194085003123	active site
1194085003124	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1194085003125	MutS domain III; Region: MutS_III; pfam05192
1194085003126	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1194085003127	Walker A/P-loop; other site
1194085003128	ATP binding site [chemical binding]; other site
1194085003129	Q-loop/lid; other site
1194085003130	ABC transporter signature motif; other site
1194085003131	Walker B; other site
1194085003132	D-loop; other site
1194085003133	H-loop/switch region; other site
1194085003134	Smr domain; Region: Smr; pfam01713
1194085003135	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1194085003136	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1194085003137	catalytic residues [active]
1194085003138	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1194085003139	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1194085003140	GIY-YIG motif/motif A; other site
1194085003141	active site
1194085003142	catalytic site [active]
1194085003143	putative DNA binding site [nucleotide binding]; other site
1194085003144	metal binding site [ion binding]; metal-binding site
1194085003145	UvrB/uvrC motif; Region: UVR; pfam02151
1194085003146	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1194085003147	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1194085003148	putative Iron-sulfur protein interface [polypeptide binding]; other site
1194085003149	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1194085003150	proximal heme binding site [chemical binding]; other site
1194085003151	distal heme binding site [chemical binding]; other site
1194085003152	putative dimer interface [polypeptide binding]; other site
1194085003153	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1194085003154	L-aspartate oxidase; Provisional; Region: PRK06175
1194085003155	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1194085003156	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1194085003157	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1194085003158	glutamate racemase; Provisional; Region: PRK00865
1194085003159	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1194085003160	active site
1194085003161	dimerization interface [polypeptide binding]; other site
1194085003162	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1194085003163	active site
1194085003164	metal binding site [ion binding]; metal-binding site
1194085003165	homotetramer interface [polypeptide binding]; other site
1194085003166	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1194085003167	formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033
1194085003168	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1194085003169	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1194085003170	beta-channel forming cytolysin; Region: hlyII; TIGR01002
1194085003171	superantigen-like protein; Reviewed; Region: PRK13350
1194085003172	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085003173	superantigen-like protein; Reviewed; Region: PRK13349
1194085003174	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085003175	superantigen-like protein; Reviewed; Region: PRK13043
1194085003176	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085003177	ornithine carbamoyltransferase; Provisional; Region: PRK04284
1194085003178	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1194085003179	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1194085003180	carbamate kinase; Reviewed; Region: PRK12686
1194085003181	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1194085003182	putative substrate binding site [chemical binding]; other site
1194085003183	nucleotide binding site [chemical binding]; other site
1194085003184	nucleotide binding site [chemical binding]; other site
1194085003185	homodimer interface [polypeptide binding]; other site
1194085003186	Predicted membrane protein [Function unknown]; Region: COG1288
1194085003187	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1194085003188	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1194085003189	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1194085003190	gating phenylalanine in ion channel; other site
1194085003191	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
1194085003192	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
1194085003193	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1194085003194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085003195	motif II; other site
1194085003196	hypothetical protein; Provisional; Region: PRK13688
1194085003197	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1194085003198	Coenzyme A binding pocket [chemical binding]; other site
1194085003199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1194085003200	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1194085003201	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1194085003202	MraZ protein; Region: MraZ; pfam02381
1194085003203	MraZ protein; Region: MraZ; pfam02381
1194085003204	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1194085003205	MraW methylase family; Region: Methyltransf_5; pfam01795
1194085003206	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
1194085003207	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1194085003208	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1194085003209	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1194085003210	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1194085003211	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1194085003212	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1194085003213	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1194085003214	Mg++ binding site [ion binding]; other site
1194085003215	putative catalytic motif [active]
1194085003216	putative substrate binding site [chemical binding]; other site
1194085003217	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1194085003218	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1194085003219	NAD binding site [chemical binding]; other site
1194085003220	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1194085003221	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1194085003222	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1194085003223	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1194085003224	Cell division protein FtsQ; Region: FtsQ; pfam03799
1194085003225	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1194085003226	Cell division protein FtsA; Region: FtsA; smart00842
1194085003227	Cell division protein FtsA; Region: FtsA; pfam14450
1194085003228	cell division protein FtsZ; Validated; Region: PRK09330
1194085003229	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1194085003230	nucleotide binding site [chemical binding]; other site
1194085003231	SulA interaction site; other site
1194085003232	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1194085003233	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1194085003234	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1194085003235	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1194085003236	catalytic residue [active]
1194085003237	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1194085003238	YGGT family; Region: YGGT; pfam02325
1194085003239	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1194085003240	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1194085003241	RNA binding surface [nucleotide binding]; other site
1194085003242	DivIVA protein; Region: DivIVA; pfam05103
1194085003243	DivIVA domain; Region: DivI1A_domain; TIGR03544
1194085003244	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1194085003245	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1194085003246	HIGH motif; other site
1194085003247	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1194085003248	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1194085003249	active site
1194085003250	KMSKS motif; other site
1194085003251	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1194085003252	tRNA binding surface [nucleotide binding]; other site
1194085003253	anticodon binding site; other site
1194085003254	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1194085003255	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1194085003256	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1194085003257	active site
1194085003258	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085003259	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085003260	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085003261	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1194085003262	lipoprotein signal peptidase; Provisional; Region: PRK14787
1194085003263	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1194085003264	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1194085003265	RNA binding surface [nucleotide binding]; other site
1194085003266	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1194085003267	active site
1194085003268	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1194085003269	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
1194085003270	uracil transporter; Provisional; Region: PRK10720
1194085003271	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1194085003272	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1194085003273	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1194085003274	dihydroorotase; Validated; Region: pyrC; PRK09357
1194085003275	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1194085003276	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1194085003277	active site
1194085003278	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1194085003279	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1194085003280	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1194085003281	catalytic site [active]
1194085003282	subunit interface [polypeptide binding]; other site
1194085003283	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1194085003284	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1194085003285	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1194085003286	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1194085003287	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1194085003288	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1194085003289	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1194085003290	IMP binding site; other site
1194085003291	dimer interface [polypeptide binding]; other site
1194085003292	interdomain contacts; other site
1194085003293	partial ornithine binding site; other site
1194085003294	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1194085003295	active site
1194085003296	dimer interface [polypeptide binding]; other site
1194085003297	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1194085003298	active site
1194085003299	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1194085003300	dimer interface [polypeptide binding]; other site
1194085003301	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1194085003302	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1194085003303	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1194085003304	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1194085003305	catalytic site [active]
1194085003306	G-X2-G-X-G-K; other site
1194085003307	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
1194085003308	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1194085003309	Flavoprotein; Region: Flavoprotein; pfam02441
1194085003310	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1194085003311	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1194085003312	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1194085003313	ATP binding site [chemical binding]; other site
1194085003314	putative Mg++ binding site [ion binding]; other site
1194085003315	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1194085003316	nucleotide binding region [chemical binding]; other site
1194085003317	ATP-binding site [chemical binding]; other site
1194085003318	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1194085003319	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1194085003320	active site
1194085003321	catalytic residues [active]
1194085003322	metal binding site [ion binding]; metal-binding site
1194085003323	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1194085003324	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1194085003325	putative active site [active]
1194085003326	substrate binding site [chemical binding]; other site
1194085003327	putative cosubstrate binding site; other site
1194085003328	catalytic site [active]
1194085003329	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1194085003330	substrate binding site [chemical binding]; other site
1194085003331	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1194085003332	NusB family; Region: NusB; pfam01029
1194085003333	putative RNA binding site [nucleotide binding]; other site
1194085003334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085003335	S-adenosylmethionine binding site [chemical binding]; other site
1194085003336	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1194085003337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085003338	FeS/SAM binding site; other site
1194085003339	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1194085003340	Protein phosphatase 2C; Region: PP2C; pfam00481
1194085003341	active site
1194085003342	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1194085003343	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1194085003344	active site
1194085003345	ATP binding site [chemical binding]; other site
1194085003346	substrate binding site [chemical binding]; other site
1194085003347	activation loop (A-loop); other site
1194085003348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1194085003349	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1194085003350	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1194085003351	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1194085003352	Predicted GTPases [General function prediction only]; Region: COG1162
1194085003353	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1194085003354	RNA binding site [nucleotide binding]; other site
1194085003355	homodimer interface [polypeptide binding]; other site
1194085003356	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1194085003357	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1194085003358	GTP/Mg2+ binding site [chemical binding]; other site
1194085003359	G4 box; other site
1194085003360	G5 box; other site
1194085003361	G1 box; other site
1194085003362	Switch I region; other site
1194085003363	G2 box; other site
1194085003364	G3 box; other site
1194085003365	Switch II region; other site
1194085003366	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1194085003367	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1194085003368	substrate binding site [chemical binding]; other site
1194085003369	hexamer interface [polypeptide binding]; other site
1194085003370	metal binding site [ion binding]; metal-binding site
1194085003371	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1194085003372	Thiamine pyrophosphokinase; Region: TPK; cd07995
1194085003373	active site
1194085003374	dimerization interface [polypeptide binding]; other site
1194085003375	thiamine binding site [chemical binding]; other site
1194085003376	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1194085003377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1194085003378	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
1194085003379	DAK2 domain; Region: Dak2; pfam02734
1194085003380	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1194085003381	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1194085003382	generic binding surface II; other site
1194085003383	ssDNA binding site; other site
1194085003384	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1194085003385	ATP binding site [chemical binding]; other site
1194085003386	putative Mg++ binding site [ion binding]; other site
1194085003387	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1194085003388	nucleotide binding region [chemical binding]; other site
1194085003389	ATP-binding site [chemical binding]; other site
1194085003390	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1194085003391	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1194085003392	active site 2 [active]
1194085003393	active site 1 [active]
1194085003394	putative phosphate acyltransferase; Provisional; Region: PRK05331
1194085003395	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1194085003396	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1194085003397	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1194085003398	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1194085003399	NAD(P) binding site [chemical binding]; other site
1194085003400	homotetramer interface [polypeptide binding]; other site
1194085003401	homodimer interface [polypeptide binding]; other site
1194085003402	active site
1194085003403	acyl carrier protein; Provisional; Region: acpP; PRK00982
1194085003404	ribonuclease III; Reviewed; Region: rnc; PRK00102
1194085003405	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1194085003406	dimerization interface [polypeptide binding]; other site
1194085003407	active site
1194085003408	metal binding site [ion binding]; metal-binding site
1194085003409	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1194085003410	dsRNA binding site [nucleotide binding]; other site
1194085003411	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1194085003412	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1194085003413	Walker A/P-loop; other site
1194085003414	ATP binding site [chemical binding]; other site
1194085003415	Q-loop/lid; other site
1194085003416	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1194085003417	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1194085003418	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1194085003419	ABC transporter signature motif; other site
1194085003420	Walker B; other site
1194085003421	D-loop; other site
1194085003422	H-loop/switch region; other site
1194085003423	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1194085003424	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1194085003425	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1194085003426	P loop; other site
1194085003427	GTP binding site [chemical binding]; other site
1194085003428	putative DNA-binding protein; Validated; Region: PRK00118
1194085003429	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1194085003430	signal recognition particle protein; Provisional; Region: PRK10867
1194085003431	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1194085003432	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1194085003433	P loop; other site
1194085003434	GTP binding site [chemical binding]; other site
1194085003435	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1194085003436	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
1194085003437	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1194085003438	RimM N-terminal domain; Region: RimM; pfam01782
1194085003439	PRC-barrel domain; Region: PRC; pfam05239
1194085003440	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1194085003441	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1194085003442	Predicted membrane protein [Function unknown]; Region: COG4485
1194085003443	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1194085003444	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1194085003445	GTP/Mg2+ binding site [chemical binding]; other site
1194085003446	G4 box; other site
1194085003447	G5 box; other site
1194085003448	G1 box; other site
1194085003449	Switch I region; other site
1194085003450	G2 box; other site
1194085003451	G3 box; other site
1194085003452	Switch II region; other site
1194085003453	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1194085003454	RNA/DNA hybrid binding site [nucleotide binding]; other site
1194085003455	active site
1194085003456	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1194085003457	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1194085003458	CoA-ligase; Region: Ligase_CoA; pfam00549
1194085003459	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1194085003460	CoA binding domain; Region: CoA_binding; pfam02629
1194085003461	CoA-ligase; Region: Ligase_CoA; pfam00549
1194085003462	FemAB family; Region: FemAB; pfam02388
1194085003463	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1194085003464	DNA protecting protein DprA; Region: dprA; TIGR00732
1194085003465	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1194085003466	DNA topoisomerase I; Validated; Region: PRK05582
1194085003467	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1194085003468	active site
1194085003469	interdomain interaction site; other site
1194085003470	putative metal-binding site [ion binding]; other site
1194085003471	nucleotide binding site [chemical binding]; other site
1194085003472	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1194085003473	domain I; other site
1194085003474	DNA binding groove [nucleotide binding]
1194085003475	phosphate binding site [ion binding]; other site
1194085003476	domain II; other site
1194085003477	domain III; other site
1194085003478	nucleotide binding site [chemical binding]; other site
1194085003479	catalytic site [active]
1194085003480	domain IV; other site
1194085003481	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1194085003482	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1194085003483	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1194085003484	Glucose inhibited division protein A; Region: GIDA; pfam01134
1194085003485	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1194085003486	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1194085003487	active site
1194085003488	DNA binding site [nucleotide binding]
1194085003489	Int/Topo IB signature motif; other site
1194085003490	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1194085003491	active site
1194085003492	HslU subunit interaction site [polypeptide binding]; other site
1194085003493	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1194085003494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085003495	Walker A motif; other site
1194085003496	ATP binding site [chemical binding]; other site
1194085003497	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1194085003498	Walker B motif; other site
1194085003499	arginine finger; other site
1194085003500	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1194085003501	transcriptional repressor CodY; Validated; Region: PRK04158
1194085003502	CodY GAF-like domain; Region: CodY; pfam06018
1194085003503	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1194085003504	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1194085003505	rRNA interaction site [nucleotide binding]; other site
1194085003506	S8 interaction site; other site
1194085003507	putative laminin-1 binding site; other site
1194085003508	elongation factor Ts; Provisional; Region: tsf; PRK09377
1194085003509	UBA/TS-N domain; Region: UBA; pfam00627
1194085003510	Elongation factor TS; Region: EF_TS; pfam00889
1194085003511	Elongation factor TS; Region: EF_TS; pfam00889
1194085003512	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1194085003513	putative nucleotide binding site [chemical binding]; other site
1194085003514	uridine monophosphate binding site [chemical binding]; other site
1194085003515	homohexameric interface [polypeptide binding]; other site
1194085003516	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1194085003517	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1194085003518	hinge region; other site
1194085003519	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1194085003520	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1194085003521	catalytic residue [active]
1194085003522	putative FPP diphosphate  binding site; other site
1194085003523	putative FPP binding hydrophobic cleft; other site
1194085003524	dimer interface [polypeptide binding]; other site
1194085003525	putative IPP diphosphate binding site; other site
1194085003526	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1194085003527	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1194085003528	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1194085003529	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1194085003530	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1194085003531	protein binding site [polypeptide binding]; other site
1194085003532	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1194085003533	putative substrate binding region [chemical binding]; other site
1194085003534	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1194085003535	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1194085003536	dimer interface [polypeptide binding]; other site
1194085003537	motif 1; other site
1194085003538	active site
1194085003539	motif 2; other site
1194085003540	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1194085003541	putative deacylase active site [active]
1194085003542	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1194085003543	active site
1194085003544	motif 3; other site
1194085003545	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1194085003546	anticodon binding site; other site
1194085003547	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1194085003548	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1194085003549	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1194085003550	generic binding surface II; other site
1194085003551	generic binding surface I; other site
1194085003552	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1194085003553	active site
1194085003554	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1194085003555	active site
1194085003556	catalytic site [active]
1194085003557	substrate binding site [chemical binding]; other site
1194085003558	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1194085003559	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1194085003560	Sm and related proteins; Region: Sm_like; cl00259
1194085003561	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1194085003562	putative oligomer interface [polypeptide binding]; other site
1194085003563	putative RNA binding site [nucleotide binding]; other site
1194085003564	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1194085003565	NusA N-terminal domain; Region: NusA_N; pfam08529
1194085003566	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1194085003567	RNA binding site [nucleotide binding]; other site
1194085003568	homodimer interface [polypeptide binding]; other site
1194085003569	NusA-like KH domain; Region: KH_5; pfam13184
1194085003570	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1194085003571	G-X-X-G motif; other site
1194085003572	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1194085003573	putative RNA binding cleft [nucleotide binding]; other site
1194085003574	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1194085003575	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1194085003576	translation initiation factor IF-2; Region: IF-2; TIGR00487
1194085003577	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1194085003578	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1194085003579	G1 box; other site
1194085003580	putative GEF interaction site [polypeptide binding]; other site
1194085003581	GTP/Mg2+ binding site [chemical binding]; other site
1194085003582	Switch I region; other site
1194085003583	G2 box; other site
1194085003584	G3 box; other site
1194085003585	Switch II region; other site
1194085003586	G4 box; other site
1194085003587	G5 box; other site
1194085003588	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1194085003589	Translation-initiation factor 2; Region: IF-2; pfam11987
1194085003590	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1194085003591	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1194085003592	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
1194085003593	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1194085003594	RNA binding site [nucleotide binding]; other site
1194085003595	active site
1194085003596	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
1194085003597	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1194085003598	active site
1194085003599	Riboflavin kinase; Region: Flavokinase; smart00904
1194085003600	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1194085003601	16S/18S rRNA binding site [nucleotide binding]; other site
1194085003602	S13e-L30e interaction site [polypeptide binding]; other site
1194085003603	25S rRNA binding site [nucleotide binding]; other site
1194085003604	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1194085003605	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1194085003606	RNase E interface [polypeptide binding]; other site
1194085003607	trimer interface [polypeptide binding]; other site
1194085003608	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1194085003609	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1194085003610	RNase E interface [polypeptide binding]; other site
1194085003611	trimer interface [polypeptide binding]; other site
1194085003612	active site
1194085003613	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1194085003614	putative nucleic acid binding region [nucleotide binding]; other site
1194085003615	G-X-X-G motif; other site
1194085003616	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1194085003617	RNA binding site [nucleotide binding]; other site
1194085003618	domain interface; other site
1194085003619	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1194085003620	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1194085003621	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1194085003622	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1194085003623	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1194085003624	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1194085003625	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1194085003626	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1194085003627	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1194085003628	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1194085003629	DNA-binding site [nucleotide binding]; DNA binding site
1194085003630	UTRA domain; Region: UTRA; pfam07702
1194085003631	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1194085003632	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1194085003633	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1194085003634	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1194085003635	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1194085003636	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1194085003637	classical (c) SDRs; Region: SDR_c; cd05233
1194085003638	NAD(P) binding site [chemical binding]; other site
1194085003639	active site
1194085003640	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1194085003641	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1194085003642	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1194085003643	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1194085003644	non-specific DNA binding site [nucleotide binding]; other site
1194085003645	salt bridge; other site
1194085003646	sequence-specific DNA binding site [nucleotide binding]; other site
1194085003647	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1194085003648	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1194085003649	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1194085003650	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1194085003651	putative MPT binding site; other site
1194085003652	recombinase A; Provisional; Region: recA; PRK09354
1194085003653	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1194085003654	hexamer interface [polypeptide binding]; other site
1194085003655	Walker A motif; other site
1194085003656	ATP binding site [chemical binding]; other site
1194085003657	Walker B motif; other site
1194085003658	phosphodiesterase; Provisional; Region: PRK12704
1194085003659	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1194085003660	Zn2+ binding site [ion binding]; other site
1194085003661	Mg2+ binding site [ion binding]; other site
1194085003662	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1194085003663	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1194085003664	putative active site [active]
1194085003665	metal binding site [ion binding]; metal-binding site
1194085003666	homodimer binding site [polypeptide binding]; other site
1194085003667	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1194085003668	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1194085003669	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1194085003670	dimer interface [polypeptide binding]; other site
1194085003671	PYR/PP interface [polypeptide binding]; other site
1194085003672	TPP binding site [chemical binding]; other site
1194085003673	substrate binding site [chemical binding]; other site
1194085003674	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1194085003675	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1194085003676	TPP-binding site [chemical binding]; other site
1194085003677	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1194085003678	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1194085003679	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1194085003680	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1194085003681	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085003682	FeS/SAM binding site; other site
1194085003683	TRAM domain; Region: TRAM; pfam01938
1194085003684	Predicted membrane protein [Function unknown]; Region: COG4550
1194085003685	Predicted membrane protein [Function unknown]; Region: COG4732
1194085003686	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1194085003687	MutS domain I; Region: MutS_I; pfam01624
1194085003688	MutS domain II; Region: MutS_II; pfam05188
1194085003689	MutS domain III; Region: MutS_III; pfam05192
1194085003690	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1194085003691	Walker A/P-loop; other site
1194085003692	ATP binding site [chemical binding]; other site
1194085003693	Q-loop/lid; other site
1194085003694	ABC transporter signature motif; other site
1194085003695	Walker B; other site
1194085003696	D-loop; other site
1194085003697	H-loop/switch region; other site
1194085003698	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1194085003699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085003700	ATP binding site [chemical binding]; other site
1194085003701	Mg2+ binding site [ion binding]; other site
1194085003702	G-X-G motif; other site
1194085003703	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1194085003704	ATP binding site [chemical binding]; other site
1194085003705	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1194085003706	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
1194085003707	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1194085003708	amphipathic channel; other site
1194085003709	Asn-Pro-Ala signature motifs; other site
1194085003710	glycerol kinase; Provisional; Region: glpK; PRK00047
1194085003711	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1194085003712	N- and C-terminal domain interface [polypeptide binding]; other site
1194085003713	active site
1194085003714	MgATP binding site [chemical binding]; other site
1194085003715	catalytic site [active]
1194085003716	metal binding site [ion binding]; metal-binding site
1194085003717	glycerol binding site [chemical binding]; other site
1194085003718	homotetramer interface [polypeptide binding]; other site
1194085003719	homodimer interface [polypeptide binding]; other site
1194085003720	FBP binding site [chemical binding]; other site
1194085003721	protein IIAGlc interface [polypeptide binding]; other site
1194085003722	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1194085003723	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1194085003724	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1194085003725	Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209
1194085003726	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1194085003727	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1194085003728	bacterial Hfq-like; Region: Hfq; cd01716
1194085003729	hexamer interface [polypeptide binding]; other site
1194085003730	Sm1 motif; other site
1194085003731	RNA binding site [nucleotide binding]; other site
1194085003732	Sm2 motif; other site
1194085003733	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1194085003734	catalytic residues [active]
1194085003735	dimer interface [polypeptide binding]; other site
1194085003736	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1194085003737	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1194085003738	HflX GTPase family; Region: HflX; cd01878
1194085003739	G1 box; other site
1194085003740	GTP/Mg2+ binding site [chemical binding]; other site
1194085003741	Switch I region; other site
1194085003742	G2 box; other site
1194085003743	G3 box; other site
1194085003744	Switch II region; other site
1194085003745	G4 box; other site
1194085003746	G5 box; other site
1194085003747	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1194085003748	Aluminium resistance protein; Region: Alum_res; pfam06838
1194085003749	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1194085003750	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1194085003751	DNA binding residues [nucleotide binding]
1194085003752	putative dimer interface [polypeptide binding]; other site
1194085003753	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1194085003754	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1194085003755	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1194085003756	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1194085003757	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1194085003758	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1194085003759	Sm and related proteins; Region: Sm_like; cl00259
1194085003760	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1194085003761	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1194085003762	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1194085003763	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1194085003764	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1194085003765	catalytic residue [active]
1194085003766	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1194085003767	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1194085003768	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1194085003769	putative active site [active]
1194085003770	catalytic site [active]
1194085003771	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1194085003772	putative active site [active]
1194085003773	catalytic site [active]
1194085003774	Staphylococcal nuclease homologues; Region: SNc; smart00318
1194085003775	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1194085003776	Catalytic site; other site
1194085003777	AAA domain; Region: AAA_11; pfam13086
1194085003778	aspartate kinase; Reviewed; Region: PRK09034
1194085003779	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1194085003780	putative catalytic residues [active]
1194085003781	putative nucleotide binding site [chemical binding]; other site
1194085003782	putative aspartate binding site [chemical binding]; other site
1194085003783	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1194085003784	allosteric regulatory residue; other site
1194085003785	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1194085003786	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1194085003787	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1194085003788	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1194085003789	threonine synthase; Reviewed; Region: PRK06721
1194085003790	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1194085003791	homodimer interface [polypeptide binding]; other site
1194085003792	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085003793	catalytic residue [active]
1194085003794	homoserine kinase; Provisional; Region: PRK01212
1194085003795	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1194085003796	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1194085003797	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085003798	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1194085003799	active site
1194085003800	motif I; other site
1194085003801	motif II; other site
1194085003802	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1194085003803	lysine transporter; Provisional; Region: PRK10836
1194085003804	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1194085003805	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1194085003806	tetramer interface [polypeptide binding]; other site
1194085003807	heme binding pocket [chemical binding]; other site
1194085003808	NADPH binding site [chemical binding]; other site
1194085003809	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1194085003810	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1194085003811	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1194085003812	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1194085003813	active site
1194085003814	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1194085003815	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1194085003816	LexA repressor; Validated; Region: PRK00215
1194085003817	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1194085003818	putative DNA binding site [nucleotide binding]; other site
1194085003819	putative Zn2+ binding site [ion binding]; other site
1194085003820	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1194085003821	Catalytic site [active]
1194085003822	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1194085003823	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1194085003824	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1194085003825	TPP-binding site [chemical binding]; other site
1194085003826	dimer interface [polypeptide binding]; other site
1194085003827	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1194085003828	PYR/PP interface [polypeptide binding]; other site
1194085003829	dimer interface [polypeptide binding]; other site
1194085003830	TPP binding site [chemical binding]; other site
1194085003831	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1194085003832	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1194085003833	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
1194085003834	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1194085003835	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1194085003836	active site
1194085003837	metal binding site [ion binding]; metal-binding site
1194085003838	DNA binding site [nucleotide binding]
1194085003839	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1194085003840	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1194085003841	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1194085003842	Walker A/P-loop; other site
1194085003843	ATP binding site [chemical binding]; other site
1194085003844	Q-loop/lid; other site
1194085003845	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1194085003846	ABC transporter signature motif; other site
1194085003847	Walker B; other site
1194085003848	D-loop; other site
1194085003849	H-loop/switch region; other site
1194085003850	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1194085003851	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954
1194085003852	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1194085003853	aconitate hydratase; Validated; Region: PRK09277
1194085003854	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1194085003855	substrate binding site [chemical binding]; other site
1194085003856	ligand binding site [chemical binding]; other site
1194085003857	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1194085003858	substrate binding site [chemical binding]; other site
1194085003859	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1194085003860	active site
1194085003861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
1194085003862	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1194085003863	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1194085003864	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085003865	ATP binding site [chemical binding]; other site
1194085003866	Mg2+ binding site [ion binding]; other site
1194085003867	G-X-G motif; other site
1194085003868	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1194085003869	anchoring element; other site
1194085003870	dimer interface [polypeptide binding]; other site
1194085003871	ATP binding site [chemical binding]; other site
1194085003872	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1194085003873	active site
1194085003874	putative metal-binding site [ion binding]; other site
1194085003875	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1194085003876	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1194085003877	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1194085003878	CAP-like domain; other site
1194085003879	active site
1194085003880	primary dimer interface [polypeptide binding]; other site
1194085003881	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1194085003882	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1194085003883	amino acid carrier protein; Region: agcS; TIGR00835
1194085003884	CAT RNA binding domain; Region: CAT_RBD; smart01061
1194085003885	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1194085003886	PRD domain; Region: PRD; pfam00874
1194085003887	PRD domain; Region: PRD; pfam00874
1194085003888	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1194085003889	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1194085003890	Predicted integral membrane protein [Function unknown]; Region: COG0392
1194085003891	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1194085003892	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1194085003893	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1194085003894	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1194085003895	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
1194085003896	active site 1 [active]
1194085003897	dimer interface [polypeptide binding]; other site
1194085003898	hexamer interface [polypeptide binding]; other site
1194085003899	active site 2 [active]
1194085003900	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1194085003901	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1194085003902	active site
1194085003903	DNA binding site [nucleotide binding]
1194085003904	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1194085003905	prephenate dehydrogenase; Validated; Region: PRK06545
1194085003906	prephenate dehydrogenase; Validated; Region: PRK08507
1194085003907	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1194085003908	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1194085003909	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1194085003910	putative oligomer interface [polypeptide binding]; other site
1194085003911	putative active site [active]
1194085003912	metal binding site [ion binding]; metal-binding site
1194085003913	anthranilate synthase component I; Provisional; Region: PRK13567
1194085003914	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1194085003915	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1194085003916	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1194085003917	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1194085003918	glutamine binding [chemical binding]; other site
1194085003919	catalytic triad [active]
1194085003920	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1194085003921	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1194085003922	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1194085003923	active site
1194085003924	ribulose/triose binding site [chemical binding]; other site
1194085003925	phosphate binding site [ion binding]; other site
1194085003926	substrate (anthranilate) binding pocket [chemical binding]; other site
1194085003927	product (indole) binding pocket [chemical binding]; other site
1194085003928	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1194085003929	active site
1194085003930	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1194085003931	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1194085003932	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085003933	catalytic residue [active]
1194085003934	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1194085003935	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1194085003936	substrate binding site [chemical binding]; other site
1194085003937	active site
1194085003938	catalytic residues [active]
1194085003939	heterodimer interface [polypeptide binding]; other site
1194085003940	FemAB family; Region: FemAB; pfam02388
1194085003941	FlxA-like protein; Region: FlxA; pfam14282
1194085003942	FemAB family; Region: FemAB; pfam02388
1194085003943	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1194085003944	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085003945	active site
1194085003946	motif I; other site
1194085003947	motif II; other site
1194085003948	SWIM zinc finger; Region: SWIM; pfam04434
1194085003949	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1194085003950	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085003951	Walker A/P-loop; other site
1194085003952	ATP binding site [chemical binding]; other site
1194085003953	Q-loop/lid; other site
1194085003954	ABC transporter signature motif; other site
1194085003955	Walker B; other site
1194085003956	D-loop; other site
1194085003957	H-loop/switch region; other site
1194085003958	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085003959	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1194085003960	Walker A/P-loop; other site
1194085003961	ATP binding site [chemical binding]; other site
1194085003962	Q-loop/lid; other site
1194085003963	ABC transporter signature motif; other site
1194085003964	Walker B; other site
1194085003965	D-loop; other site
1194085003966	H-loop/switch region; other site
1194085003967	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1194085003968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085003969	dimer interface [polypeptide binding]; other site
1194085003970	conserved gate region; other site
1194085003971	putative PBP binding loops; other site
1194085003972	ABC-ATPase subunit interface; other site
1194085003973	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1194085003974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085003975	dimer interface [polypeptide binding]; other site
1194085003976	conserved gate region; other site
1194085003977	putative PBP binding loops; other site
1194085003978	ABC-ATPase subunit interface; other site
1194085003979	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
1194085003980	oligoendopeptidase F; Region: pepF; TIGR00181
1194085003981	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1194085003982	active site
1194085003983	Zn binding site [ion binding]; other site
1194085003984	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1194085003985	PhoU domain; Region: PhoU; pfam01895
1194085003986	PhoU domain; Region: PhoU; pfam01895
1194085003987	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
1194085003988	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1194085003989	Walker A/P-loop; other site
1194085003990	ATP binding site [chemical binding]; other site
1194085003991	Q-loop/lid; other site
1194085003992	ABC transporter signature motif; other site
1194085003993	Walker B; other site
1194085003994	D-loop; other site
1194085003995	H-loop/switch region; other site
1194085003996	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1194085003997	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085003998	dimer interface [polypeptide binding]; other site
1194085003999	conserved gate region; other site
1194085004000	putative PBP binding loops; other site
1194085004001	ABC-ATPase subunit interface; other site
1194085004002	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1194085004003	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085004004	dimer interface [polypeptide binding]; other site
1194085004005	conserved gate region; other site
1194085004006	ABC-ATPase subunit interface; other site
1194085004007	phosphate binding protein; Region: ptsS_2; TIGR02136
1194085004008	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1194085004009	S1 domain; Region: S1_2; pfam13509
1194085004010	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1194085004011	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1194085004012	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1194085004013	ABC transporter; Region: ABC_tran_2; pfam12848
1194085004014	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1194085004015	aspartate kinase; Reviewed; Region: PRK06635
1194085004016	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1194085004017	putative nucleotide binding site [chemical binding]; other site
1194085004018	putative catalytic residues [active]
1194085004019	putative Mg ion binding site [ion binding]; other site
1194085004020	putative aspartate binding site [chemical binding]; other site
1194085004021	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
1194085004022	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
1194085004023	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1194085004024	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1194085004025	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1194085004026	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1194085004027	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1194085004028	dimer interface [polypeptide binding]; other site
1194085004029	active site
1194085004030	catalytic residue [active]
1194085004031	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1194085004032	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1194085004033	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1194085004034	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1194085004035	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1194085004036	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1194085004037	active site
1194085004038	trimer interface [polypeptide binding]; other site
1194085004039	substrate binding site [chemical binding]; other site
1194085004040	CoA binding site [chemical binding]; other site
1194085004041	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1194085004042	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1194085004043	metal binding site [ion binding]; metal-binding site
1194085004044	dimer interface [polypeptide binding]; other site
1194085004045	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1194085004046	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1194085004047	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1194085004048	catalytic residue [active]
1194085004049	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1194085004050	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1194085004051	active site
1194085004052	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1194085004053	substrate binding site [chemical binding]; other site
1194085004054	catalytic residues [active]
1194085004055	dimer interface [polypeptide binding]; other site
1194085004056	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
1194085004057	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1194085004058	DNA-binding site [nucleotide binding]; DNA binding site
1194085004059	RNA-binding motif; other site
1194085004060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699
1194085004061	acylphosphatase; Provisional; Region: PRK14431
1194085004062	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
1194085004063	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1194085004064	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
1194085004065	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1194085004066	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1194085004067	metal ion-dependent adhesion site (MIDAS); other site
1194085004068	MoxR-like ATPases [General function prediction only]; Region: COG0714
1194085004069	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085004070	Walker A motif; other site
1194085004071	ATP binding site [chemical binding]; other site
1194085004072	Walker B motif; other site
1194085004073	arginine finger; other site
1194085004074	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1194085004075	active site
1194085004076	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1194085004077	active site
1194085004078	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1194085004079	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1194085004080	E3 interaction surface; other site
1194085004081	lipoyl attachment site [posttranslational modification]; other site
1194085004082	e3 binding domain; Region: E3_binding; pfam02817
1194085004083	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1194085004084	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1194085004085	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1194085004086	TPP-binding site [chemical binding]; other site
1194085004087	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1194085004088	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1194085004089	HAMP domain; Region: HAMP; pfam00672
1194085004090	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1194085004091	dimer interface [polypeptide binding]; other site
1194085004092	phosphorylation site [posttranslational modification]
1194085004093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085004094	ATP binding site [chemical binding]; other site
1194085004095	Mg2+ binding site [ion binding]; other site
1194085004096	G-X-G motif; other site
1194085004097	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1194085004098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085004099	active site
1194085004100	phosphorylation site [posttranslational modification]
1194085004101	intermolecular recognition site; other site
1194085004102	dimerization interface [polypeptide binding]; other site
1194085004103	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1194085004104	DNA binding site [nucleotide binding]
1194085004105	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1194085004106	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1194085004107	active site
1194085004108	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1194085004109	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1194085004110	active site
1194085004111	homodimer interface [polypeptide binding]; other site
1194085004112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085004113	Coenzyme A binding pocket [chemical binding]; other site
1194085004114	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1194085004115	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1194085004116	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1194085004117	protein binding site [polypeptide binding]; other site
1194085004118	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1194085004119	Catalytic dyad [active]
1194085004120	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1194085004121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479
1194085004122	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1194085004123	HPr interaction site; other site
1194085004124	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1194085004125	active site
1194085004126	phosphorylation site [posttranslational modification]
1194085004127	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1194085004128	SelR domain; Region: SelR; pfam01641
1194085004129	methionine sulfoxide reductase A; Provisional; Region: PRK13014
1194085004130	EDD domain protein, DegV family; Region: DegV; TIGR00762
1194085004131	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1194085004132	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1194085004133	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1194085004134	folate binding site [chemical binding]; other site
1194085004135	NADP+ binding site [chemical binding]; other site
1194085004136	thymidylate synthase; Region: thym_sym; TIGR03284
1194085004137	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1194085004138	dimerization interface [polypeptide binding]; other site
1194085004139	active site
1194085004140	Disulphide isomerase; Region: Disulph_isomer; cl05813
1194085004141	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1194085004142	Virulence factor; Region: Virulence_fact; pfam13769
1194085004143	HEAT repeats; Region: HEAT_2; pfam13646
1194085004144	HEAT repeat; Region: HEAT; pfam02985
1194085004145	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
1194085004146	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1194085004147	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1194085004148	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1194085004149	RNA/DNA hybrid binding site [nucleotide binding]; other site
1194085004150	active site
1194085004151	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1194085004152	Amino acid permease; Region: AA_permease_2; pfam13520
1194085004153	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1194085004154	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1194085004155	tetramer interface [polypeptide binding]; other site
1194085004156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085004157	catalytic residue [active]
1194085004158	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1194085004159	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1194085004160	hexamer interface [polypeptide binding]; other site
1194085004161	ligand binding site [chemical binding]; other site
1194085004162	putative active site [active]
1194085004163	NAD(P) binding site [chemical binding]; other site
1194085004164	5'-3' exonuclease; Region: 53EXOc; smart00475
1194085004165	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1194085004166	active site
1194085004167	metal binding site 1 [ion binding]; metal-binding site
1194085004168	putative 5' ssDNA interaction site; other site
1194085004169	metal binding site 3; metal-binding site
1194085004170	metal binding site 2 [ion binding]; metal-binding site
1194085004171	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1194085004172	putative DNA binding site [nucleotide binding]; other site
1194085004173	putative metal binding site [ion binding]; other site
1194085004174	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1194085004175	Dynamin family; Region: Dynamin_N; pfam00350
1194085004176	G1 box; other site
1194085004177	GTP/Mg2+ binding site [chemical binding]; other site
1194085004178	G2 box; other site
1194085004179	Switch I region; other site
1194085004180	G3 box; other site
1194085004181	Switch II region; other site
1194085004182	G4 box; other site
1194085004183	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1194085004184	Dynamin family; Region: Dynamin_N; pfam00350
1194085004185	G1 box; other site
1194085004186	GTP/Mg2+ binding site [chemical binding]; other site
1194085004187	G2 box; other site
1194085004188	Switch I region; other site
1194085004189	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1194085004190	G3 box; other site
1194085004191	Switch II region; other site
1194085004192	GTP/Mg2+ binding site [chemical binding]; other site
1194085004193	G4 box; other site
1194085004194	G5 box; other site
1194085004195	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1194085004196	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1194085004197	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1194085004198	Cobalt transport protein component CbiN; Region: CbiN; cl00842
1194085004199	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1194085004200	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1194085004201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1194085004202	cell division protein GpsB; Provisional; Region: PRK14127
1194085004203	DivIVA domain; Region: DivI1A_domain; TIGR03544
1194085004204	hypothetical protein; Provisional; Region: PRK13660
1194085004205	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
1194085004206	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1194085004207	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1194085004208	Transglycosylase; Region: Transgly; pfam00912
1194085004209	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1194085004210	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1194085004211	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1194085004212	minor groove reading motif; other site
1194085004213	helix-hairpin-helix signature motif; other site
1194085004214	substrate binding pocket [chemical binding]; other site
1194085004215	active site
1194085004216	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1194085004217	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1194085004218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
1194085004219	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1194085004220	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1194085004221	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1194085004222	putative dimer interface [polypeptide binding]; other site
1194085004223	putative anticodon binding site; other site
1194085004224	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1194085004225	homodimer interface [polypeptide binding]; other site
1194085004226	motif 1; other site
1194085004227	motif 2; other site
1194085004228	active site
1194085004229	motif 3; other site
1194085004230	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1194085004231	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1194085004232	active site
1194085004233	catalytic site [active]
1194085004234	substrate binding site [chemical binding]; other site
1194085004235	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1194085004236	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1194085004237	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1194085004238	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1194085004239	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1194085004240	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1194085004241	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1194085004242	active site
1194085004243	NTP binding site [chemical binding]; other site
1194085004244	metal binding triad [ion binding]; metal-binding site
1194085004245	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1194085004246	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1194085004247	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1194085004248	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1194085004249	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1194085004250	homodimer interface [polypeptide binding]; other site
1194085004251	metal binding site [ion binding]; metal-binding site
1194085004252	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1194085004253	Protein of unknown function (DUF1405); Region: DUF1405; cl01798
1194085004254	Uncharacterized conserved protein [Function unknown]; Region: COG5582
1194085004255	UPF0302 domain; Region: UPF0302; pfam08864
1194085004256	A short protein domain of unknown function; Region: IDEAL; smart00914
1194085004257	TPR repeat; Region: TPR_11; pfam13414
1194085004258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1194085004259	binding surface
1194085004260	TPR motif; other site
1194085004261	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1194085004262	TPR motif; other site
1194085004263	binding surface
1194085004264	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1194085004265	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1194085004266	hinge; other site
1194085004267	active site
1194085004268	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1194085004269	active site
1194085004270	NAD binding site [chemical binding]; other site
1194085004271	metal binding site [ion binding]; metal-binding site
1194085004272	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1194085004273	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1194085004274	Tetramer interface [polypeptide binding]; other site
1194085004275	active site
1194085004276	FMN-binding site [chemical binding]; other site
1194085004277	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1194085004278	active site
1194085004279	multimer interface [polypeptide binding]; other site
1194085004280	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1194085004281	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1194085004282	substrate binding pocket [chemical binding]; other site
1194085004283	chain length determination region; other site
1194085004284	substrate-Mg2+ binding site; other site
1194085004285	catalytic residues [active]
1194085004286	aspartate-rich region 1; other site
1194085004287	active site lid residues [active]
1194085004288	aspartate-rich region 2; other site
1194085004289	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1194085004290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085004291	S-adenosylmethionine binding site [chemical binding]; other site
1194085004292	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1194085004293	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1194085004294	IHF dimer interface [polypeptide binding]; other site
1194085004295	IHF - DNA interface [nucleotide binding]; other site
1194085004296	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1194085004297	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1194085004298	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1194085004299	GTP-binding protein Der; Reviewed; Region: PRK00093
1194085004300	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1194085004301	G1 box; other site
1194085004302	GTP/Mg2+ binding site [chemical binding]; other site
1194085004303	Switch I region; other site
1194085004304	G2 box; other site
1194085004305	Switch II region; other site
1194085004306	G3 box; other site
1194085004307	G4 box; other site
1194085004308	G5 box; other site
1194085004309	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1194085004310	G1 box; other site
1194085004311	GTP/Mg2+ binding site [chemical binding]; other site
1194085004312	Switch I region; other site
1194085004313	G2 box; other site
1194085004314	G3 box; other site
1194085004315	Switch II region; other site
1194085004316	G4 box; other site
1194085004317	G5 box; other site
1194085004318	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1194085004319	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1194085004320	RNA binding site [nucleotide binding]; other site
1194085004321	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1194085004322	RNA binding site [nucleotide binding]; other site
1194085004323	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1194085004324	RNA binding site [nucleotide binding]; other site
1194085004325	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1194085004326	RNA binding site [nucleotide binding]; other site
1194085004327	cytidylate kinase; Provisional; Region: cmk; PRK00023
1194085004328	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1194085004329	CMP-binding site; other site
1194085004330	The sites determining sugar specificity; other site
1194085004331	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1194085004332	active site
1194085004333	homotetramer interface [polypeptide binding]; other site
1194085004334	homodimer interface [polypeptide binding]; other site
1194085004335	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1194085004336	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1194085004337	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085004338	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1194085004339	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1194085004340	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1194085004341	ATP binding site [chemical binding]; other site
1194085004342	putative Mg++ binding site [ion binding]; other site
1194085004343	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1194085004344	nucleotide binding region [chemical binding]; other site
1194085004345	ATP-binding site [chemical binding]; other site
1194085004346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1194085004347	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1194085004348	Predicted membrane protein [Function unknown]; Region: COG3601
1194085004349	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1194085004350	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1194085004351	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1194085004352	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1194085004353	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1194085004354	dimerization interface [polypeptide binding]; other site
1194085004355	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1194085004356	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1194085004357	dimer interface [polypeptide binding]; other site
1194085004358	phosphorylation site [posttranslational modification]
1194085004359	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085004360	ATP binding site [chemical binding]; other site
1194085004361	Mg2+ binding site [ion binding]; other site
1194085004362	G-X-G motif; other site
1194085004363	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1194085004364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085004365	active site
1194085004366	phosphorylation site [posttranslational modification]
1194085004367	intermolecular recognition site; other site
1194085004368	dimerization interface [polypeptide binding]; other site
1194085004369	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1194085004370	DNA binding site [nucleotide binding]
1194085004371	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1194085004372	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1194085004373	RNA binding surface [nucleotide binding]; other site
1194085004374	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1194085004375	active site
1194085004376	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1194085004377	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1194085004378	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
1194085004379	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1194085004380	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1194085004381	active site
1194085004382	Int/Topo IB signature motif; other site
1194085004383	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1194085004384	metal binding site 2 [ion binding]; metal-binding site
1194085004385	putative DNA binding helix; other site
1194085004386	metal binding site 1 [ion binding]; metal-binding site
1194085004387	dimer interface [polypeptide binding]; other site
1194085004388	structural Zn2+ binding site [ion binding]; other site
1194085004389	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1194085004390	dimer interface [polypeptide binding]; other site
1194085004391	ADP-ribose binding site [chemical binding]; other site
1194085004392	active site
1194085004393	nudix motif; other site
1194085004394	metal binding site [ion binding]; metal-binding site
1194085004395	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1194085004396	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1194085004397	active site
1194085004398	catalytic tetrad [active]
1194085004399	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1194085004400	classical (c) SDRs; Region: SDR_c; cd05233
1194085004401	NAD(P) binding site [chemical binding]; other site
1194085004402	active site
1194085004403	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1194085004404	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1194085004405	ribonuclease Z; Region: RNase_Z; TIGR02651
1194085004406	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1194085004407	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1194085004408	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1194085004409	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1194085004410	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1194085004411	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1194085004412	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1194085004413	Ca binding site [ion binding]; other site
1194085004414	active site
1194085004415	catalytic site [active]
1194085004416	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1194085004417	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1194085004418	DNA binding site [nucleotide binding]
1194085004419	domain linker motif; other site
1194085004420	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1194085004421	putative ligand binding site [chemical binding]; other site
1194085004422	putative dimerization interface [polypeptide binding]; other site
1194085004423	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1194085004424	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1194085004425	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1194085004426	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1194085004427	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1194085004428	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1194085004429	peptidase T-like protein; Region: PepT-like; TIGR01883
1194085004430	metal binding site [ion binding]; metal-binding site
1194085004431	putative dimer interface [polypeptide binding]; other site
1194085004432	Predicted membrane protein [Function unknown]; Region: COG4129
1194085004433	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1194085004434	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1194085004435	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1194085004436	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1194085004437	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1194085004438	E3 interaction surface; other site
1194085004439	lipoyl attachment site [posttranslational modification]; other site
1194085004440	e3 binding domain; Region: E3_binding; pfam02817
1194085004441	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1194085004442	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1194085004443	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1194085004444	alpha subunit interface [polypeptide binding]; other site
1194085004445	TPP binding site [chemical binding]; other site
1194085004446	heterodimer interface [polypeptide binding]; other site
1194085004447	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1194085004448	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1194085004449	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1194085004450	tetramer interface [polypeptide binding]; other site
1194085004451	TPP-binding site [chemical binding]; other site
1194085004452	heterodimer interface [polypeptide binding]; other site
1194085004453	phosphorylation loop region [posttranslational modification]
1194085004454	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1194085004455	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1194085004456	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085004457	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1194085004458	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1194085004459	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1194085004460	Walker A/P-loop; other site
1194085004461	ATP binding site [chemical binding]; other site
1194085004462	Q-loop/lid; other site
1194085004463	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1194085004464	ABC transporter signature motif; other site
1194085004465	Walker B; other site
1194085004466	D-loop; other site
1194085004467	H-loop/switch region; other site
1194085004468	arginine repressor; Provisional; Region: PRK04280
1194085004469	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1194085004470	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1194085004471	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1194085004472	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1194085004473	substrate binding pocket [chemical binding]; other site
1194085004474	chain length determination region; other site
1194085004475	substrate-Mg2+ binding site; other site
1194085004476	catalytic residues [active]
1194085004477	aspartate-rich region 1; other site
1194085004478	active site lid residues [active]
1194085004479	aspartate-rich region 2; other site
1194085004480	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
1194085004481	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1194085004482	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1194085004483	generic binding surface II; other site
1194085004484	generic binding surface I; other site
1194085004485	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1194085004486	putative RNA binding site [nucleotide binding]; other site
1194085004487	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1194085004488	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1194085004489	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1194085004490	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1194085004491	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1194085004492	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1194085004493	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1194085004494	carboxyltransferase (CT) interaction site; other site
1194085004495	biotinylation site [posttranslational modification]; other site
1194085004496	elongation factor P; Validated; Region: PRK00529
1194085004497	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1194085004498	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1194085004499	RNA binding site [nucleotide binding]; other site
1194085004500	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1194085004501	RNA binding site [nucleotide binding]; other site
1194085004502	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1194085004503	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1194085004504	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1194085004505	active site
1194085004506	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1194085004507	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1194085004508	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1194085004509	active site residue [active]
1194085004510	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1194085004511	tetramer interface [polypeptide binding]; other site
1194085004512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085004513	catalytic residue [active]
1194085004514	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1194085004515	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1194085004516	tetramer interface [polypeptide binding]; other site
1194085004517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085004518	catalytic residue [active]
1194085004519	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1194085004520	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1194085004521	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1194085004522	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1194085004523	ADP binding site [chemical binding]; other site
1194085004524	magnesium binding site [ion binding]; other site
1194085004525	putative shikimate binding site; other site
1194085004526	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1194085004527	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1194085004528	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1194085004529	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1194085004530	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1194085004531	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1194085004532	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1194085004533	Type II/IV secretion system protein; Region: T2SE; pfam00437
1194085004534	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1194085004535	Walker A motif; other site
1194085004536	ATP binding site [chemical binding]; other site
1194085004537	Walker B motif; other site
1194085004538	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1194085004539	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1194085004540	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1194085004541	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1194085004542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
1194085004543	Rhomboid family; Region: Rhomboid; pfam01694
1194085004544	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1194085004545	binding surface
1194085004546	TPR motif; other site
1194085004547	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1194085004548	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1194085004549	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1194085004550	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1194085004551	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1194085004552	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1194085004553	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1194085004554	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1194085004555	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1194085004556	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1194085004557	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1194085004558	metal binding site 2 [ion binding]; metal-binding site
1194085004559	putative DNA binding helix; other site
1194085004560	metal binding site 1 [ion binding]; metal-binding site
1194085004561	dimer interface [polypeptide binding]; other site
1194085004562	structural Zn2+ binding site [ion binding]; other site
1194085004563	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1194085004564	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085004565	ABC-ATPase subunit  interface; other site
1194085004566	dimer interface [polypeptide binding]; other site
1194085004567	putative PBP binding regions; other site
1194085004568	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1194085004569	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1194085004570	endonuclease IV; Provisional; Region: PRK01060
1194085004571	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1194085004572	AP (apurinic/apyrimidinic) site pocket; other site
1194085004573	DNA interaction; other site
1194085004574	Metal-binding active site; metal-binding site
1194085004575	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1194085004576	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1194085004577	ATP binding site [chemical binding]; other site
1194085004578	putative Mg++ binding site [ion binding]; other site
1194085004579	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1194085004580	nucleotide binding region [chemical binding]; other site
1194085004581	ATP-binding site [chemical binding]; other site
1194085004582	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1194085004583	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1194085004584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1194085004585	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1194085004586	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1194085004587	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1194085004588	Family of unknown function (DUF633); Region: DUF633; pfam04816
1194085004589	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1194085004590	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1194085004591	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1194085004592	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1194085004593	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1194085004594	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1194085004595	DNA binding residues [nucleotide binding]
1194085004596	DNA primase, catalytic core; Region: dnaG; TIGR01391
1194085004597	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1194085004598	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1194085004599	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1194085004600	active site
1194085004601	metal binding site [ion binding]; metal-binding site
1194085004602	interdomain interaction site; other site
1194085004603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
1194085004604	HTH domain; Region: HTH_11; cl17392
1194085004605	FOG: CBS domain [General function prediction only]; Region: COG0517
1194085004606	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1194085004607	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1194085004608	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1194085004609	motif 1; other site
1194085004610	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1194085004611	active site
1194085004612	motif 2; other site
1194085004613	motif 3; other site
1194085004614	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1194085004615	anticodon binding site; other site
1194085004616	DNA repair protein RecO; Region: reco; TIGR00613
1194085004617	Recombination protein O N terminal; Region: RecO_N; pfam11967
1194085004618	Recombination protein O C terminal; Region: RecO_C; pfam02565
1194085004619	GTPase Era; Reviewed; Region: era; PRK00089
1194085004620	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1194085004621	G1 box; other site
1194085004622	GTP/Mg2+ binding site [chemical binding]; other site
1194085004623	Switch I region; other site
1194085004624	G2 box; other site
1194085004625	Switch II region; other site
1194085004626	G3 box; other site
1194085004627	G4 box; other site
1194085004628	G5 box; other site
1194085004629	KH domain; Region: KH_2; pfam07650
1194085004630	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1194085004631	active site
1194085004632	catalytic motif [active]
1194085004633	Zn binding site [ion binding]; other site
1194085004634	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1194085004635	metal-binding heat shock protein; Provisional; Region: PRK00016
1194085004636	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1194085004637	PhoH-like protein; Region: PhoH; pfam02562
1194085004638	hypothetical protein; Provisional; Region: PRK13665
1194085004639	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1194085004640	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1194085004641	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1194085004642	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1194085004643	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085004644	FeS/SAM binding site; other site
1194085004645	TRAM domain; Region: TRAM; cl01282
1194085004646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1194085004647	RNA methyltransferase, RsmE family; Region: TIGR00046
1194085004648	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1194085004649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085004650	S-adenosylmethionine binding site [chemical binding]; other site
1194085004651	chaperone protein DnaJ; Provisional; Region: PRK14280
1194085004652	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1194085004653	HSP70 interaction site [polypeptide binding]; other site
1194085004654	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1194085004655	substrate binding site [polypeptide binding]; other site
1194085004656	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1194085004657	Zn binding sites [ion binding]; other site
1194085004658	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1194085004659	dimer interface [polypeptide binding]; other site
1194085004660	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1194085004661	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1194085004662	nucleotide binding site [chemical binding]; other site
1194085004663	NEF interaction site [polypeptide binding]; other site
1194085004664	SBD interface [polypeptide binding]; other site
1194085004665	heat shock protein GrpE; Provisional; Region: PRK14140
1194085004666	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1194085004667	dimer interface [polypeptide binding]; other site
1194085004668	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1194085004669	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1194085004670	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
1194085004671	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
1194085004672	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085004673	FeS/SAM binding site; other site
1194085004674	HemN C-terminal domain; Region: HemN_C; pfam06969
1194085004675	GTP-binding protein LepA; Provisional; Region: PRK05433
1194085004676	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1194085004677	G1 box; other site
1194085004678	putative GEF interaction site [polypeptide binding]; other site
1194085004679	GTP/Mg2+ binding site [chemical binding]; other site
1194085004680	Switch I region; other site
1194085004681	G2 box; other site
1194085004682	G3 box; other site
1194085004683	Switch II region; other site
1194085004684	G4 box; other site
1194085004685	G5 box; other site
1194085004686	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1194085004687	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1194085004688	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1194085004689	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1194085004690	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1194085004691	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1194085004692	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1194085004693	Competence protein; Region: Competence; pfam03772
1194085004694	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1194085004695	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1194085004696	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1194085004697	catalytic motif [active]
1194085004698	Zn binding site [ion binding]; other site
1194085004699	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1194085004700	Helix-hairpin-helix motif; Region: HHH; pfam00633
1194085004701	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1194085004702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085004703	S-adenosylmethionine binding site [chemical binding]; other site
1194085004704	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1194085004705	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1194085004706	Zn2+ binding site [ion binding]; other site
1194085004707	Mg2+ binding site [ion binding]; other site
1194085004708	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1194085004709	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
1194085004710	active site
1194085004711	(T/H)XGH motif; other site
1194085004712	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1194085004713	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1194085004714	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1194085004715	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1194085004716	shikimate binding site; other site
1194085004717	NAD(P) binding site [chemical binding]; other site
1194085004718	GTPase YqeH; Provisional; Region: PRK13796
1194085004719	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1194085004720	GTP/Mg2+ binding site [chemical binding]; other site
1194085004721	G4 box; other site
1194085004722	G5 box; other site
1194085004723	G1 box; other site
1194085004724	Switch I region; other site
1194085004725	G2 box; other site
1194085004726	G3 box; other site
1194085004727	Switch II region; other site
1194085004728	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1194085004729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085004730	active site
1194085004731	motif I; other site
1194085004732	motif II; other site
1194085004733	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1194085004734	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1194085004735	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1194085004736	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1194085004737	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085004738	Fic family protein [Function unknown]; Region: COG3177
1194085004739	Fic/DOC family; Region: Fic; pfam02661
1194085004740	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1194085004741	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1194085004742	putative active site [active]
1194085004743	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1194085004744	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1194085004745	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1194085004746	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1194085004747	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1194085004748	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1194085004749	carboxyltransferase (CT) interaction site; other site
1194085004750	biotinylation site [posttranslational modification]; other site
1194085004751	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1194085004752	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1194085004753	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1194085004754	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1194085004755	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1194085004756	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1194085004757	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1194085004758	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1194085004759	Sugar specificity; other site
1194085004760	Pyrimidine base specificity; other site
1194085004761	ATP-binding site [chemical binding]; other site
1194085004762	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1194085004763	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1194085004764	Peptidase family U32; Region: Peptidase_U32; pfam01136
1194085004765	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1194085004766	Peptidase family U32; Region: Peptidase_U32; pfam01136
1194085004767	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1194085004768	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085004769	S-adenosylmethionine binding site [chemical binding]; other site
1194085004770	hypothetical protein; Provisional; Region: PRK13678
1194085004771	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1194085004772	hypothetical protein; Provisional; Region: PRK05473
1194085004773	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1194085004774	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1194085004775	motif 1; other site
1194085004776	active site
1194085004777	motif 2; other site
1194085004778	motif 3; other site
1194085004779	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1194085004780	DHHA1 domain; Region: DHHA1; pfam02272
1194085004781	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1194085004782	AAA domain; Region: AAA_30; pfam13604
1194085004783	Family description; Region: UvrD_C_2; pfam13538
1194085004784	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1194085004785	binding surface
1194085004786	TPR motif; other site
1194085004787	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1194085004788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1194085004789	binding surface
1194085004790	TPR motif; other site
1194085004791	TPR repeat; Region: TPR_11; pfam13414
1194085004792	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1194085004793	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1194085004794	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1194085004795	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1194085004796	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1194085004797	catalytic residue [active]
1194085004798	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1194085004799	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1194085004800	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1194085004801	Predicted transcriptional regulator [Transcription]; Region: COG1959
1194085004802	Transcriptional regulator; Region: Rrf2; pfam02082
1194085004803	recombination factor protein RarA; Reviewed; Region: PRK13342
1194085004804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085004805	Walker A motif; other site
1194085004806	ATP binding site [chemical binding]; other site
1194085004807	Walker B motif; other site
1194085004808	arginine finger; other site
1194085004809	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1194085004810	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1194085004811	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1194085004812	putative ATP binding site [chemical binding]; other site
1194085004813	putative substrate interface [chemical binding]; other site
1194085004814	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1194085004815	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1194085004816	dimer interface [polypeptide binding]; other site
1194085004817	anticodon binding site; other site
1194085004818	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1194085004819	homodimer interface [polypeptide binding]; other site
1194085004820	motif 1; other site
1194085004821	active site
1194085004822	motif 2; other site
1194085004823	GAD domain; Region: GAD; pfam02938
1194085004824	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1194085004825	motif 3; other site
1194085004826	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1194085004827	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1194085004828	dimer interface [polypeptide binding]; other site
1194085004829	motif 1; other site
1194085004830	active site
1194085004831	motif 2; other site
1194085004832	motif 3; other site
1194085004833	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1194085004834	anticodon binding site; other site
1194085004835	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1194085004836	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1194085004837	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1194085004838	active site
1194085004839	metal binding site [ion binding]; metal-binding site
1194085004840	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1194085004841	putative active site [active]
1194085004842	dimerization interface [polypeptide binding]; other site
1194085004843	putative tRNAtyr binding site [nucleotide binding]; other site
1194085004844	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1194085004845	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1194085004846	Zn2+ binding site [ion binding]; other site
1194085004847	Mg2+ binding site [ion binding]; other site
1194085004848	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1194085004849	synthetase active site [active]
1194085004850	NTP binding site [chemical binding]; other site
1194085004851	metal binding site [ion binding]; metal-binding site
1194085004852	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1194085004853	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1194085004854	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1194085004855	active site
1194085004856	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1194085004857	DHH family; Region: DHH; pfam01368
1194085004858	DHHA1 domain; Region: DHHA1; pfam02272
1194085004859	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1194085004860	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1194085004861	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1194085004862	Protein export membrane protein; Region: SecD_SecF; cl14618
1194085004863	Protein export membrane protein; Region: SecD_SecF; pfam02355
1194085004864	Preprotein translocase subunit; Region: YajC; pfam02699
1194085004865	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1194085004866	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1194085004867	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1194085004868	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1194085004869	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1194085004870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085004871	Walker A motif; other site
1194085004872	ATP binding site [chemical binding]; other site
1194085004873	Walker B motif; other site
1194085004874	arginine finger; other site
1194085004875	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1194085004876	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1194085004877	RuvA N terminal domain; Region: RuvA_N; pfam01330
1194085004878	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1194085004879	ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492
1194085004880	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1194085004881	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1194085004882	GTP1/OBG; Region: GTP1_OBG; pfam01018
1194085004883	Obg GTPase; Region: Obg; cd01898
1194085004884	G1 box; other site
1194085004885	GTP/Mg2+ binding site [chemical binding]; other site
1194085004886	Switch I region; other site
1194085004887	G2 box; other site
1194085004888	G3 box; other site
1194085004889	Switch II region; other site
1194085004890	G4 box; other site
1194085004891	G5 box; other site
1194085004892	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1194085004893	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1194085004894	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
1194085004895	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1194085004896	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1194085004897	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1194085004898	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
1194085004899	rod shape-determining protein MreC; Region: MreC; pfam04085
1194085004900	hypothetical protein; Reviewed; Region: PRK00024
1194085004901	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1194085004902	MPN+ (JAMM) motif; other site
1194085004903	Zinc-binding site [ion binding]; other site
1194085004904	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1194085004905	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1194085004906	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1194085004907	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1194085004908	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1194085004909	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1194085004910	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1194085004911	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1194085004912	active site
1194085004913	HIGH motif; other site
1194085004914	nucleotide binding site [chemical binding]; other site
1194085004915	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1194085004916	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1194085004917	active site
1194085004918	KMSKS motif; other site
1194085004919	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1194085004920	tRNA binding surface [nucleotide binding]; other site
1194085004921	anticodon binding site; other site
1194085004922	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1194085004923	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1194085004924	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1194085004925	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1194085004926	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1194085004927	inhibitor-cofactor binding pocket; inhibition site
1194085004928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085004929	catalytic residue [active]
1194085004930	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1194085004931	dimer interface [polypeptide binding]; other site
1194085004932	active site
1194085004933	Schiff base residues; other site
1194085004934	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1194085004935	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1194085004936	active site
1194085004937	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1194085004938	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1194085004939	domain interfaces; other site
1194085004940	active site
1194085004941	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
1194085004942	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1194085004943	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1194085004944	tRNA; other site
1194085004945	putative tRNA binding site [nucleotide binding]; other site
1194085004946	putative NADP binding site [chemical binding]; other site
1194085004947	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1194085004948	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1194085004949	G1 box; other site
1194085004950	GTP/Mg2+ binding site [chemical binding]; other site
1194085004951	Switch I region; other site
1194085004952	G2 box; other site
1194085004953	G3 box; other site
1194085004954	Switch II region; other site
1194085004955	G4 box; other site
1194085004956	G5 box; other site
1194085004957	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1194085004958	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1194085004959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085004960	Walker A motif; other site
1194085004961	ATP binding site [chemical binding]; other site
1194085004962	Walker B motif; other site
1194085004963	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1194085004964	trigger factor; Provisional; Region: tig; PRK01490
1194085004965	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1194085004966	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1194085004967	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
1194085004968	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1194085004969	23S rRNA binding site [nucleotide binding]; other site
1194085004970	L21 binding site [polypeptide binding]; other site
1194085004971	L13 binding site [polypeptide binding]; other site
1194085004972	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1194085004973	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1194085004974	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1194085004975	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1194085004976	lysine transporter; Provisional; Region: PRK10836
1194085004977	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1194085004978	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1194085004979	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1194085004980	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1194085004981	active site
1194085004982	dimer interface [polypeptide binding]; other site
1194085004983	motif 1; other site
1194085004984	motif 2; other site
1194085004985	motif 3; other site
1194085004986	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1194085004987	anticodon binding site; other site
1194085004988	primosomal protein DnaI; Reviewed; Region: PRK08939
1194085004989	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1194085004990	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085004991	Walker A motif; other site
1194085004992	ATP binding site [chemical binding]; other site
1194085004993	Walker B motif; other site
1194085004994	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1194085004995	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1194085004996	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1194085004997	ATP cone domain; Region: ATP-cone; pfam03477
1194085004998	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
1194085004999	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1194085005000	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1194085005001	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1194085005002	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1194085005003	CoA-binding site [chemical binding]; other site
1194085005004	ATP-binding [chemical binding]; other site
1194085005005	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1194085005006	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1194085005007	DNA binding site [nucleotide binding]
1194085005008	catalytic residue [active]
1194085005009	H2TH interface [polypeptide binding]; other site
1194085005010	putative catalytic residues [active]
1194085005011	turnover-facilitating residue; other site
1194085005012	intercalation triad [nucleotide binding]; other site
1194085005013	8OG recognition residue [nucleotide binding]; other site
1194085005014	putative reading head residues; other site
1194085005015	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1194085005016	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1194085005017	DNA polymerase I; Provisional; Region: PRK05755
1194085005018	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1194085005019	active site
1194085005020	metal binding site 1 [ion binding]; metal-binding site
1194085005021	putative 5' ssDNA interaction site; other site
1194085005022	metal binding site 3; metal-binding site
1194085005023	metal binding site 2 [ion binding]; metal-binding site
1194085005024	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1194085005025	putative DNA binding site [nucleotide binding]; other site
1194085005026	putative metal binding site [ion binding]; other site
1194085005027	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1194085005028	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1194085005029	active site
1194085005030	DNA binding site [nucleotide binding]
1194085005031	catalytic site [active]
1194085005032	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1194085005033	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1194085005034	dimer interface [polypeptide binding]; other site
1194085005035	phosphorylation site [posttranslational modification]
1194085005036	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085005037	ATP binding site [chemical binding]; other site
1194085005038	Mg2+ binding site [ion binding]; other site
1194085005039	G-X-G motif; other site
1194085005040	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1194085005041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085005042	active site
1194085005043	phosphorylation site [posttranslational modification]
1194085005044	intermolecular recognition site; other site
1194085005045	dimerization interface [polypeptide binding]; other site
1194085005046	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1194085005047	DNA binding site [nucleotide binding]
1194085005048	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1194085005049	isocitrate dehydrogenase; Validated; Region: PRK07362
1194085005050	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1194085005051	dimer interface [polypeptide binding]; other site
1194085005052	Citrate synthase; Region: Citrate_synt; pfam00285
1194085005053	active site
1194085005054	citrylCoA binding site [chemical binding]; other site
1194085005055	oxalacetate/citrate binding site [chemical binding]; other site
1194085005056	coenzyme A binding site [chemical binding]; other site
1194085005057	catalytic triad [active]
1194085005058	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1194085005059	pyruvate kinase; Provisional; Region: PRK06354
1194085005060	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1194085005061	domain interfaces; other site
1194085005062	active site
1194085005063	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1194085005064	6-phosphofructokinase; Provisional; Region: PRK03202
1194085005065	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1194085005066	active site
1194085005067	ADP/pyrophosphate binding site [chemical binding]; other site
1194085005068	dimerization interface [polypeptide binding]; other site
1194085005069	allosteric effector site; other site
1194085005070	fructose-1,6-bisphosphate binding site; other site
1194085005071	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1194085005072	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1194085005073	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1194085005074	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1194085005075	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1194085005076	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1194085005077	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1194085005078	putative NAD(P) binding site [chemical binding]; other site
1194085005079	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1194085005080	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1194085005081	active site
1194085005082	PHP Thumb interface [polypeptide binding]; other site
1194085005083	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1194085005084	generic binding surface I; other site
1194085005085	generic binding surface II; other site
1194085005086	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1194085005087	DHH family; Region: DHH; pfam01368
1194085005088	DHHA1 domain; Region: DHHA1; pfam02272
1194085005089	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1194085005090	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1194085005091	DNA-binding site [nucleotide binding]; DNA binding site
1194085005092	DRTGG domain; Region: DRTGG; pfam07085
1194085005093	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1194085005094	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1194085005095	active site 2 [active]
1194085005096	active site 1 [active]
1194085005097	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1194085005098	Ligand Binding Site [chemical binding]; other site
1194085005099	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1194085005100	metal-dependent hydrolase; Provisional; Region: PRK00685
1194085005101	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1194085005102	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1194085005103	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1194085005104	active site
1194085005105	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1194085005106	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1194085005107	hexamer interface [polypeptide binding]; other site
1194085005108	ligand binding site [chemical binding]; other site
1194085005109	putative active site [active]
1194085005110	NAD(P) binding site [chemical binding]; other site
1194085005111	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1194085005112	Ligand Binding Site [chemical binding]; other site
1194085005113	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1194085005114	propionate/acetate kinase; Provisional; Region: PRK12379
1194085005115	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1194085005116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085005117	S-adenosylmethionine binding site [chemical binding]; other site
1194085005118	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1194085005119	dimer interface [polypeptide binding]; other site
1194085005120	catalytic triad [active]
1194085005121	peroxidatic and resolving cysteines [active]
1194085005122	hypothetical protein; Provisional; Region: PRK10621
1194085005123	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1194085005124	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1194085005125	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1194085005126	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1194085005127	Ligand Binding Site [chemical binding]; other site
1194085005128	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1194085005129	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1194085005130	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1194085005131	catalytic residue [active]
1194085005132	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
1194085005133	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1194085005134	GAF domain; Region: GAF_2; pfam13185
1194085005135	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1194085005136	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1194085005137	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1194085005138	RNA binding surface [nucleotide binding]; other site
1194085005139	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1194085005140	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1194085005141	active site
1194085005142	catalytic site [active]
1194085005143	OsmC-like protein; Region: OsmC; cl00767
1194085005144	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1194085005145	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1194085005146	catalytic residue [active]
1194085005147	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
1194085005148	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1194085005149	ligand binding site [chemical binding]; other site
1194085005150	NAD binding site [chemical binding]; other site
1194085005151	dimerization interface [polypeptide binding]; other site
1194085005152	catalytic site [active]
1194085005153	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1194085005154	putative L-serine binding site [chemical binding]; other site
1194085005155	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085005156	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1194085005157	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085005158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085005159	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
1194085005160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085005161	motif II; other site
1194085005162	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1194085005163	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1194085005164	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1194085005165	active site turn [active]
1194085005166	phosphorylation site [posttranslational modification]
1194085005167	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1194085005168	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1194085005169	putative acyl-acceptor binding pocket; other site
1194085005170	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1194085005171	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1194085005172	protein binding site [polypeptide binding]; other site
1194085005173	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1194085005174	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1194085005175	active site
1194085005176	HIGH motif; other site
1194085005177	dimer interface [polypeptide binding]; other site
1194085005178	KMSKS motif; other site
1194085005179	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1194085005180	RNA binding surface [nucleotide binding]; other site
1194085005181	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1194085005182	Transglycosylase; Region: Transgly; pfam00912
1194085005183	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
1194085005184	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1194085005185	NEAr Transporter domain; Region: NEAT; smart00725
1194085005186	NEAr Transporter domain; Region: NEAT; smart00725
1194085005187	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1194085005188	heme-binding site [chemical binding]; other site
1194085005189	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1194085005190	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1194085005191	Potassium binding sites [ion binding]; other site
1194085005192	Cesium cation binding sites [ion binding]; other site
1194085005193	acetyl-CoA synthetase; Provisional; Region: PRK04319
1194085005194	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1194085005195	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1194085005196	active site
1194085005197	acyl-activating enzyme (AAE) consensus motif; other site
1194085005198	putative CoA binding site [chemical binding]; other site
1194085005199	AMP binding site [chemical binding]; other site
1194085005200	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1194085005201	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1194085005202	active site
1194085005203	Zn binding site [ion binding]; other site
1194085005204	catabolite control protein A; Region: ccpA; TIGR01481
1194085005205	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1194085005206	DNA binding site [nucleotide binding]
1194085005207	domain linker motif; other site
1194085005208	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1194085005209	dimerization interface [polypeptide binding]; other site
1194085005210	effector binding site; other site
1194085005211	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1194085005212	Chorismate mutase type II; Region: CM_2; cl00693
1194085005213	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1194085005214	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1194085005215	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1194085005216	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1194085005217	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1194085005218	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1194085005219	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1194085005220	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1194085005221	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1194085005222	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1194085005223	putative tRNA-binding site [nucleotide binding]; other site
1194085005224	hypothetical protein; Provisional; Region: PRK13668
1194085005225	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1194085005226	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1194085005227	catalytic residues [active]
1194085005228	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1194085005229	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1194085005230	oligomer interface [polypeptide binding]; other site
1194085005231	active site
1194085005232	metal binding site [ion binding]; metal-binding site
1194085005233	Predicted small secreted protein [Function unknown]; Region: COG5584
1194085005234	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1194085005235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085005236	S-adenosylmethionine binding site [chemical binding]; other site
1194085005237	Phosphotransferase enzyme family; Region: APH; pfam01636
1194085005238	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1194085005239	active site
1194085005240	substrate binding site [chemical binding]; other site
1194085005241	ATP binding site [chemical binding]; other site
1194085005242	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1194085005243	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1194085005244	homodimer interface [polypeptide binding]; other site
1194085005245	substrate-cofactor binding pocket; other site
1194085005246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085005247	catalytic residue [active]
1194085005248	dipeptidase PepV; Reviewed; Region: PRK07318
1194085005249	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1194085005250	active site
1194085005251	metal binding site [ion binding]; metal-binding site
1194085005252	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1194085005253	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1194085005254	RNA binding surface [nucleotide binding]; other site
1194085005255	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1194085005256	active site
1194085005257	uracil binding [chemical binding]; other site
1194085005258	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1194085005259	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1194085005260	HI0933-like protein; Region: HI0933_like; pfam03486
1194085005261	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1194085005262	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1194085005263	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1194085005264	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005265	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005266	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005267	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005268	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005269	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005270	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005271	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005272	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005273	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005274	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005275	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005276	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005277	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005278	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085005279	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1194085005280	active site residue [active]
1194085005281	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1194085005282	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1194085005283	HIGH motif; other site
1194085005284	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1194085005285	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1194085005286	active site
1194085005287	KMSKS motif; other site
1194085005288	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1194085005289	tRNA binding surface [nucleotide binding]; other site
1194085005290	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085005291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085005292	putative substrate translocation pore; other site
1194085005293	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1194085005294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085005295	S-adenosylmethionine binding site [chemical binding]; other site
1194085005296	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085005297	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1194085005298	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1194085005299	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1194085005300	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1194085005301	homopentamer interface [polypeptide binding]; other site
1194085005302	active site
1194085005303	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1194085005304	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1194085005305	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1194085005306	dimerization interface [polypeptide binding]; other site
1194085005307	active site
1194085005308	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1194085005309	Lumazine binding domain; Region: Lum_binding; pfam00677
1194085005310	Lumazine binding domain; Region: Lum_binding; pfam00677
1194085005311	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1194085005312	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1194085005313	catalytic motif [active]
1194085005314	Zn binding site [ion binding]; other site
1194085005315	RibD C-terminal domain; Region: RibD_C; cl17279
1194085005316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1194085005317	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1194085005318	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1194085005319	arsenical pump membrane protein; Provisional; Region: PRK15445
1194085005320	transmembrane helices; other site
1194085005321	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1194085005322	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1194085005323	active site
1194085005324	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1194085005325	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1194085005326	CAAX protease self-immunity; Region: Abi; pfam02517
1194085005327	CAAX protease self-immunity; Region: Abi; pfam02517
1194085005328	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1194085005329	active site
1194085005330	intersubunit interactions; other site
1194085005331	catalytic residue [active]
1194085005332	camphor resistance protein CrcB; Provisional; Region: PRK14201
1194085005333	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1194085005334	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1194085005335	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1194085005336	active site
1194085005337	catalytic tetrad [active]
1194085005338	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1194085005339	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1194085005340	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1194085005341	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1194085005342	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1194085005343	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1194085005344	active site
1194085005345	substrate-binding site [chemical binding]; other site
1194085005346	metal-binding site [ion binding]
1194085005347	ATP binding site [chemical binding]; other site
1194085005348	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1194085005349	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1194085005350	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
1194085005351	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
1194085005352	nudix motif; other site
1194085005353	Haemolytic domain; Region: Haemolytic; pfam01809
1194085005354	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1194085005355	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1194085005356	metal binding site [ion binding]; metal-binding site
1194085005357	substrate binding pocket [chemical binding]; other site
1194085005358	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1194085005359	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
1194085005360	acyl-activating enzyme (AAE) consensus motif; other site
1194085005361	putative AMP binding site [chemical binding]; other site
1194085005362	putative active site [active]
1194085005363	putative CoA binding site [chemical binding]; other site
1194085005364	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1194085005365	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1194085005366	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
1194085005367	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
1194085005368	Family description; Region: UvrD_C_2; pfam13538
1194085005369	Polysaccharide lyase family 8, super-sandwich domain; Region: Lyase_8; pfam02278
1194085005370	Polysaccharide lyase family 8, C-terminal beta-sandwich domain; Region: Lyase_8_C; pfam02884
1194085005371	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1194085005372	Peptidase family M23; Region: Peptidase_M23; pfam01551
1194085005373	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1194085005374	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1194085005375	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1194085005376	transposase/IS protein; Provisional; Region: PRK09183
1194085005377	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085005378	Walker A motif; other site
1194085005379	ATP binding site [chemical binding]; other site
1194085005380	Walker B motif; other site
1194085005381	arginine finger; other site
1194085005382	Winged helix-turn helix; Region: HTH_29; pfam13551
1194085005383	Integrase core domain; Region: rve; pfam00665
1194085005384	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1194085005385	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1194085005386	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1194085005387	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1194085005388	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1194085005389	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1194085005390	ferrochelatase; Provisional; Region: PRK12435
1194085005391	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1194085005392	C-terminal domain interface [polypeptide binding]; other site
1194085005393	active site
1194085005394	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1194085005395	active site
1194085005396	N-terminal domain interface [polypeptide binding]; other site
1194085005397	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1194085005398	substrate binding site [chemical binding]; other site
1194085005399	active site
1194085005400	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1194085005401	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1194085005402	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1194085005403	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1194085005404	Walker A/P-loop; other site
1194085005405	ATP binding site [chemical binding]; other site
1194085005406	Q-loop/lid; other site
1194085005407	ABC transporter signature motif; other site
1194085005408	Walker B; other site
1194085005409	D-loop; other site
1194085005410	H-loop/switch region; other site
1194085005411	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1194085005412	HIT family signature motif; other site
1194085005413	catalytic residue [active]
1194085005414	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
1194085005415	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1194085005416	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
1194085005417	SurA N-terminal domain; Region: SurA_N_3; cl07813
1194085005418	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1194085005419	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1194085005420	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1194085005421	generic binding surface II; other site
1194085005422	generic binding surface I; other site
1194085005423	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1194085005424	Zn2+ binding site [ion binding]; other site
1194085005425	Mg2+ binding site [ion binding]; other site
1194085005426	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1194085005427	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1194085005428	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
1194085005429	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1194085005430	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1194085005431	active site
1194085005432	metal binding site [ion binding]; metal-binding site
1194085005433	DNA binding site [nucleotide binding]
1194085005434	hypothetical protein; Provisional; Region: PRK13676
1194085005435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1194085005436	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1194085005437	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1194085005438	non-specific DNA binding site [nucleotide binding]; other site
1194085005439	salt bridge; other site
1194085005440	sequence-specific DNA binding site [nucleotide binding]; other site
1194085005441	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1194085005442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085005443	active site
1194085005444	phosphorylation site [posttranslational modification]
1194085005445	intermolecular recognition site; other site
1194085005446	dimerization interface [polypeptide binding]; other site
1194085005447	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1194085005448	DNA binding residues [nucleotide binding]
1194085005449	dimerization interface [polypeptide binding]; other site
1194085005450	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1194085005451	GAF domain; Region: GAF_3; pfam13492
1194085005452	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1194085005453	Histidine kinase; Region: HisKA_3; pfam07730
1194085005454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085005455	ATP binding site [chemical binding]; other site
1194085005456	Mg2+ binding site [ion binding]; other site
1194085005457	G-X-G motif; other site
1194085005458	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1194085005459	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1194085005460	active site
1194085005461	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1194085005462	Class II fumarases; Region: Fumarase_classII; cd01362
1194085005463	active site
1194085005464	tetramer interface [polypeptide binding]; other site
1194085005465	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
1194085005466	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1194085005467	active site
1194085005468	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1194085005469	epoxyqueuosine reductase; Region: TIGR00276
1194085005470	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1194085005471	HEAT repeats; Region: HEAT_2; pfam13646
1194085005472	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1194085005473	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1194085005474	Walker A/P-loop; other site
1194085005475	ATP binding site [chemical binding]; other site
1194085005476	Q-loop/lid; other site
1194085005477	ABC transporter signature motif; other site
1194085005478	Walker B; other site
1194085005479	D-loop; other site
1194085005480	H-loop/switch region; other site
1194085005481	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1194085005482	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1194085005483	substrate binding pocket [chemical binding]; other site
1194085005484	membrane-bound complex binding site; other site
1194085005485	hinge residues; other site
1194085005486	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1194085005487	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085005488	dimer interface [polypeptide binding]; other site
1194085005489	conserved gate region; other site
1194085005490	putative PBP binding loops; other site
1194085005491	ABC-ATPase subunit interface; other site
1194085005492	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1194085005493	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1194085005494	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1194085005495	metal binding site 2 [ion binding]; metal-binding site
1194085005496	putative DNA binding helix; other site
1194085005497	metal binding site 1 [ion binding]; metal-binding site
1194085005498	dimer interface [polypeptide binding]; other site
1194085005499	structural Zn2+ binding site [ion binding]; other site
1194085005500	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
1194085005501	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1194085005502	putative ligand binding site [chemical binding]; other site
1194085005503	NAD binding site [chemical binding]; other site
1194085005504	catalytic site [active]
1194085005505	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1194085005506	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1194085005507	catalytic triad [active]
1194085005508	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1194085005509	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1194085005510	inhibitor-cofactor binding pocket; inhibition site
1194085005511	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085005512	catalytic residue [active]
1194085005513	Predicted membrane protein [Function unknown]; Region: COG4129
1194085005514	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1194085005515	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1194085005516	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1194085005517	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1194085005518	Walker A/P-loop; other site
1194085005519	ATP binding site [chemical binding]; other site
1194085005520	Q-loop/lid; other site
1194085005521	ABC transporter signature motif; other site
1194085005522	Walker B; other site
1194085005523	D-loop; other site
1194085005524	H-loop/switch region; other site
1194085005525	hypothetical protein; Provisional; Region: PRK13662
1194085005526	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1194085005527	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1194085005528	minor groove reading motif; other site
1194085005529	helix-hairpin-helix signature motif; other site
1194085005530	substrate binding pocket [chemical binding]; other site
1194085005531	active site
1194085005532	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1194085005533	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1194085005534	DNA binding and oxoG recognition site [nucleotide binding]
1194085005535	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1194085005536	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1194085005537	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085005538	Walker A/P-loop; other site
1194085005539	ATP binding site [chemical binding]; other site
1194085005540	Q-loop/lid; other site
1194085005541	ABC transporter signature motif; other site
1194085005542	Walker B; other site
1194085005543	H-loop/switch region; other site
1194085005544	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1194085005545	recombination regulator RecX; Provisional; Region: recX; PRK14135
1194085005546	glycosyltransferase; Provisional; Region: PRK13481
1194085005547	Transglycosylase; Region: Transgly; pfam00912
1194085005548	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1194085005549	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1194085005550	proposed catalytic triad [active]
1194085005551	conserved cys residue [active]
1194085005552	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1194085005553	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085005554	FeS/SAM binding site; other site
1194085005555	YfkB-like domain; Region: YfkB; pfam08756
1194085005556	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1194085005557	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1194085005558	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1194085005559	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
1194085005560	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1194085005561	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1194085005562	active site
1194085005563	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1194085005564	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1194085005565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085005566	active site
1194085005567	phosphorylation site [posttranslational modification]
1194085005568	intermolecular recognition site; other site
1194085005569	dimerization interface [polypeptide binding]; other site
1194085005570	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1194085005571	DNA binding residues [nucleotide binding]
1194085005572	dimerization interface [polypeptide binding]; other site
1194085005573	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1194085005574	Histidine kinase; Region: HisKA_3; pfam07730
1194085005575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085005576	ATP binding site [chemical binding]; other site
1194085005577	Mg2+ binding site [ion binding]; other site
1194085005578	G-X-G motif; other site
1194085005579	Predicted membrane protein [Function unknown]; Region: COG4758
1194085005580	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1194085005581	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1194085005582	active site
1194085005583	Predicted membrane protein [Function unknown]; Region: COG4129
1194085005584	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1194085005585	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1194085005586	catalytic triad [active]
1194085005587	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1194085005588	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1194085005589	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1194085005590	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1194085005591	Ferritin-like domain; Region: Ferritin; pfam00210
1194085005592	ferroxidase diiron center [ion binding]; other site
1194085005593	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1194085005594	active site
1194085005595	catalytic site [active]
1194085005596	substrate binding site [chemical binding]; other site
1194085005597	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1194085005598	active site
1194085005599	DNA polymerase IV; Validated; Region: PRK02406
1194085005600	DNA binding site [nucleotide binding]
1194085005601	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1194085005602	TRAM domain; Region: TRAM; cl01282
1194085005603	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1194085005604	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085005605	S-adenosylmethionine binding site [chemical binding]; other site
1194085005606	putative lipid kinase; Reviewed; Region: PRK13337
1194085005607	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1194085005608	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
1194085005609	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1194085005610	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1194085005611	GatB domain; Region: GatB_Yqey; pfam02637
1194085005612	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1194085005613	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1194085005614	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1194085005615	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1194085005616	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1194085005617	Na binding site [ion binding]; other site
1194085005618	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
1194085005619	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1194085005620	putative dimer interface [polypeptide binding]; other site
1194085005621	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1194085005622	putative dimer interface [polypeptide binding]; other site
1194085005623	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1194085005624	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1194085005625	nucleotide binding pocket [chemical binding]; other site
1194085005626	K-X-D-G motif; other site
1194085005627	catalytic site [active]
1194085005628	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1194085005629	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1194085005630	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1194085005631	Dimer interface [polypeptide binding]; other site
1194085005632	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1194085005633	Part of AAA domain; Region: AAA_19; pfam13245
1194085005634	Family description; Region: UvrD_C_2; pfam13538
1194085005635	PcrB family; Region: PcrB; pfam01884
1194085005636	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1194085005637	substrate binding site [chemical binding]; other site
1194085005638	putative active site [active]
1194085005639	dimer interface [polypeptide binding]; other site
1194085005640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
1194085005641	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1194085005642	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1194085005643	tetramer interface [polypeptide binding]; other site
1194085005644	active site
1194085005645	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1194085005646	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1194085005647	NETI protein; Region: NETI; pfam14044
1194085005648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
1194085005649	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1194085005650	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1194085005651	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1194085005652	homodimer interface [polypeptide binding]; other site
1194085005653	NAD binding pocket [chemical binding]; other site
1194085005654	ATP binding pocket [chemical binding]; other site
1194085005655	Mg binding site [ion binding]; other site
1194085005656	active-site loop [active]
1194085005657	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1194085005658	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1194085005659	active site
1194085005660	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
1194085005661	active site
1194085005662	dimer interface [polypeptide binding]; other site
1194085005663	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1194085005664	Prephenate dehydratase; Region: PDT; pfam00800
1194085005665	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1194085005666	putative L-Phe binding site [chemical binding]; other site
1194085005667	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1194085005668	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1194085005669	transmembrane helices; other site
1194085005670	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1194085005671	Isochorismatase family; Region: Isochorismatase; pfam00857
1194085005672	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1194085005673	catalytic triad [active]
1194085005674	conserved cis-peptide bond; other site
1194085005675	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1194085005676	DHH family; Region: DHH; pfam01368
1194085005677	DHHA2 domain; Region: DHHA2; pfam02833
1194085005678	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1194085005679	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1194085005680	NAD(P) binding site [chemical binding]; other site
1194085005681	catalytic residues [active]
1194085005682	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
1194085005683	YolD-like protein; Region: YolD; pfam08863
1194085005684	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
1194085005685	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
1194085005686	active site
1194085005687	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
1194085005688	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1194085005689	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1194085005690	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1194085005691	Bacterial PH domain; Region: DUF304; cl01348
1194085005692	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1194085005693	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1194085005694	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1194085005695	Walker A/P-loop; other site
1194085005696	ATP binding site [chemical binding]; other site
1194085005697	Q-loop/lid; other site
1194085005698	ABC transporter signature motif; other site
1194085005699	Walker B; other site
1194085005700	D-loop; other site
1194085005701	H-loop/switch region; other site
1194085005702	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1194085005703	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1194085005704	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1194085005705	Walker A/P-loop; other site
1194085005706	ATP binding site [chemical binding]; other site
1194085005707	Q-loop/lid; other site
1194085005708	ABC transporter signature motif; other site
1194085005709	Walker B; other site
1194085005710	D-loop; other site
1194085005711	H-loop/switch region; other site
1194085005712	Predicted transcriptional regulators [Transcription]; Region: COG1725
1194085005713	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1194085005714	DNA-binding site [nucleotide binding]; DNA binding site
1194085005715	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1194085005716	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1194085005717	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085005718	homodimer interface [polypeptide binding]; other site
1194085005719	catalytic residue [active]
1194085005720	MAP domain; Region: MAP; pfam03642
1194085005721	MAP domain; Region: MAP; pfam03642
1194085005722	MAP domain; Region: MAP; pfam03642
1194085005723	MAP domain; Region: MAP; pfam03642
1194085005724	MAP domain; Region: MAP; pfam03642
1194085005725	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
1194085005726	putative catalytic site [active]
1194085005727	metal binding site A [ion binding]; metal-binding site
1194085005728	phosphate binding site [ion binding]; other site
1194085005729	metal binding site C [ion binding]; metal-binding site
1194085005730	metal binding site B [ion binding]; metal-binding site
1194085005731	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1194085005732	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1194085005733	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1194085005734	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1194085005735	metal binding site [ion binding]; metal-binding site
1194085005736	dimer interface [polypeptide binding]; other site
1194085005737	Cation transport protein; Region: TrkH; cl17365
1194085005738	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1194085005739	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1194085005740	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1194085005741	ring oligomerisation interface [polypeptide binding]; other site
1194085005742	ATP/Mg binding site [chemical binding]; other site
1194085005743	stacking interactions; other site
1194085005744	hinge regions; other site
1194085005745	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1194085005746	oligomerisation interface [polypeptide binding]; other site
1194085005747	mobile loop; other site
1194085005748	roof hairpin; other site
1194085005749	CAAX protease self-immunity; Region: Abi; pfam02517
1194085005750	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1194085005751	dimer interface [polypeptide binding]; other site
1194085005752	FMN binding site [chemical binding]; other site
1194085005753	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1194085005754	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1194085005755	putative active site [active]
1194085005756	catalytic triad [active]
1194085005757	putative dimer interface [polypeptide binding]; other site
1194085005758	delta-hemolysin; Provisional; Region: PRK14752
1194085005759	Accessory gene regulator B; Region: AgrB; smart00793
1194085005760	Staphylococcal AgrD protein; Region: AgrD; smart00794
1194085005761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085005762	Mg2+ binding site [ion binding]; other site
1194085005763	G-X-G motif; other site
1194085005764	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1194085005765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085005766	active site
1194085005767	phosphorylation site [posttranslational modification]
1194085005768	intermolecular recognition site; other site
1194085005769	dimerization interface [polypeptide binding]; other site
1194085005770	LytTr DNA-binding domain; Region: LytTR; pfam04397
1194085005771	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1194085005772	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1194085005773	putative substrate binding site [chemical binding]; other site
1194085005774	putative ATP binding site [chemical binding]; other site
1194085005775	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1194085005776	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1194085005777	substrate binding [chemical binding]; other site
1194085005778	active site
1194085005779	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1194085005780	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1194085005781	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1194085005782	DNA binding site [nucleotide binding]
1194085005783	domain linker motif; other site
1194085005784	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1194085005785	dimerization interface [polypeptide binding]; other site
1194085005786	ligand binding site [chemical binding]; other site
1194085005787	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1194085005788	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1194085005789	CPxP  motif; other site
1194085005790	Predicted transporter component [General function prediction only]; Region: COG2391
1194085005791	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
1194085005792	Sulphur transport; Region: Sulf_transp; pfam04143
1194085005793	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
1194085005794	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1194085005795	CoA binding domain; Region: CoA_binding; pfam02629
1194085005796	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1194085005797	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1194085005798	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1194085005799	ABC transporter; Region: ABC_tran_2; pfam12848
1194085005800	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1194085005801	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085005802	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
1194085005803	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085005804	Walker A/P-loop; other site
1194085005805	ATP binding site [chemical binding]; other site
1194085005806	Q-loop/lid; other site
1194085005807	ABC transporter signature motif; other site
1194085005808	Walker B; other site
1194085005809	D-loop; other site
1194085005810	H-loop/switch region; other site
1194085005811	UGMP family protein; Validated; Region: PRK09604
1194085005812	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1194085005813	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1194085005814	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085005815	Coenzyme A binding pocket [chemical binding]; other site
1194085005816	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1194085005817	Glycoprotease family; Region: Peptidase_M22; pfam00814
1194085005818	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1194085005819	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1194085005820	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1194085005821	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
1194085005822	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1194085005823	PYR/PP interface [polypeptide binding]; other site
1194085005824	dimer interface [polypeptide binding]; other site
1194085005825	TPP binding site [chemical binding]; other site
1194085005826	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1194085005827	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1194085005828	TPP-binding site [chemical binding]; other site
1194085005829	dimer interface [polypeptide binding]; other site
1194085005830	acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562
1194085005831	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
1194085005832	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1194085005833	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1194085005834	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1194085005835	2-isopropylmalate synthase; Validated; Region: PRK00915
1194085005836	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1194085005837	active site
1194085005838	catalytic residues [active]
1194085005839	metal binding site [ion binding]; metal-binding site
1194085005840	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1194085005841	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1194085005842	tartrate dehydrogenase; Region: TTC; TIGR02089
1194085005843	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1194085005844	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1194085005845	substrate binding site [chemical binding]; other site
1194085005846	ligand binding site [chemical binding]; other site
1194085005847	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1194085005848	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1194085005849	substrate binding site [chemical binding]; other site
1194085005850	threonine dehydratase; Validated; Region: PRK08639
1194085005851	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1194085005852	tetramer interface [polypeptide binding]; other site
1194085005853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085005854	catalytic residue [active]
1194085005855	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1194085005856	putative Ile/Val binding site [chemical binding]; other site
1194085005857	hypothetical protein; Provisional; Region: PRK04351
1194085005858	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1194085005859	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1194085005860	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1194085005861	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1194085005862	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1194085005863	RNA binding site [nucleotide binding]; other site
1194085005864	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
1194085005865	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1194085005866	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1194085005867	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1194085005868	DNA binding residues [nucleotide binding]
1194085005869	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1194085005870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085005871	ATP binding site [chemical binding]; other site
1194085005872	Mg2+ binding site [ion binding]; other site
1194085005873	G-X-G motif; other site
1194085005874	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1194085005875	anti sigma factor interaction site; other site
1194085005876	regulatory phosphorylation site [posttranslational modification]; other site
1194085005877	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1194085005878	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
1194085005879	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1194085005880	PemK-like protein; Region: PemK; pfam02452
1194085005881	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1194085005882	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1194085005883	active site
1194085005884	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1194085005885	dimer interface [polypeptide binding]; other site
1194085005886	substrate binding site [chemical binding]; other site
1194085005887	catalytic residues [active]
1194085005888	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1194085005889	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1194085005890	Predicted membrane protein [Function unknown]; Region: COG3428
1194085005891	Bacterial PH domain; Region: DUF304; pfam03703
1194085005892	Bacterial PH domain; Region: DUF304; pfam03703
1194085005893	Bacterial PH domain; Region: DUF304; cl01348
1194085005894	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1194085005895	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
1194085005896	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1194085005897	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1194085005898	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
1194085005899	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1194085005900	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1194085005901	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1194085005902	Ligand Binding Site [chemical binding]; other site
1194085005903	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1194085005904	dimer interface [polypeptide binding]; other site
1194085005905	phosphorylation site [posttranslational modification]
1194085005906	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085005907	ATP binding site [chemical binding]; other site
1194085005908	Mg2+ binding site [ion binding]; other site
1194085005909	G-X-G motif; other site
1194085005910	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1194085005911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085005912	active site
1194085005913	phosphorylation site [posttranslational modification]
1194085005914	intermolecular recognition site; other site
1194085005915	dimerization interface [polypeptide binding]; other site
1194085005916	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1194085005917	DNA binding site [nucleotide binding]
1194085005918	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1194085005919	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1194085005920	ATP binding site [chemical binding]; other site
1194085005921	Mg++ binding site [ion binding]; other site
1194085005922	motif III; other site
1194085005923	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1194085005924	nucleotide binding region [chemical binding]; other site
1194085005925	ATP-binding site [chemical binding]; other site
1194085005926	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1194085005927	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1194085005928	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1194085005929	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1194085005930	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1194085005931	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1194085005932	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1194085005933	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1194085005934	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1194085005935	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
1194085005936	putative homodimer interface [polypeptide binding]; other site
1194085005937	putative homotetramer interface [polypeptide binding]; other site
1194085005938	allosteric switch controlling residues; other site
1194085005939	putative metal binding site [ion binding]; other site
1194085005940	putative homodimer-homodimer interface [polypeptide binding]; other site
1194085005941	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1194085005942	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1194085005943	putative active site [active]
1194085005944	catalytic site [active]
1194085005945	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1194085005946	putative active site [active]
1194085005947	catalytic site [active]
1194085005948	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1194085005949	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1194085005950	Zn2+ binding site [ion binding]; other site
1194085005951	Mg2+ binding site [ion binding]; other site
1194085005952	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1194085005953	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1194085005954	thiamine phosphate binding site [chemical binding]; other site
1194085005955	active site
1194085005956	pyrophosphate binding site [ion binding]; other site
1194085005957	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1194085005958	substrate binding site [chemical binding]; other site
1194085005959	multimerization interface [polypeptide binding]; other site
1194085005960	ATP binding site [chemical binding]; other site
1194085005961	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1194085005962	dimer interface [polypeptide binding]; other site
1194085005963	substrate binding site [chemical binding]; other site
1194085005964	ATP binding site [chemical binding]; other site
1194085005965	thiaminase II; Region: salvage_TenA; TIGR04306
1194085005966	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1194085005967	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1194085005968	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1194085005969	dimer interface [polypeptide binding]; other site
1194085005970	ssDNA binding site [nucleotide binding]; other site
1194085005971	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1194085005972	transposase/IS protein; Provisional; Region: PRK09183
1194085005973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085005974	Walker A motif; other site
1194085005975	ATP binding site [chemical binding]; other site
1194085005976	Walker B motif; other site
1194085005977	arginine finger; other site
1194085005978	Winged helix-turn helix; Region: HTH_29; pfam13551
1194085005979	Integrase core domain; Region: rve; pfam00665
1194085005980	YwpF-like protein; Region: YwpF; pfam14183
1194085005981	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1194085005982	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1194085005983	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1194085005984	hinge; other site
1194085005985	active site
1194085005986	Predicted membrane protein [Function unknown]; Region: COG4836
1194085005987	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
1194085005988	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1194085005989	gamma subunit interface [polypeptide binding]; other site
1194085005990	epsilon subunit interface [polypeptide binding]; other site
1194085005991	LBP interface [polypeptide binding]; other site
1194085005992	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1194085005993	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1194085005994	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1194085005995	alpha subunit interaction interface [polypeptide binding]; other site
1194085005996	Walker A motif; other site
1194085005997	ATP binding site [chemical binding]; other site
1194085005998	Walker B motif; other site
1194085005999	inhibitor binding site; inhibition site
1194085006000	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1194085006001	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1194085006002	core domain interface [polypeptide binding]; other site
1194085006003	delta subunit interface [polypeptide binding]; other site
1194085006004	epsilon subunit interface [polypeptide binding]; other site
1194085006005	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1194085006006	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1194085006007	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1194085006008	beta subunit interaction interface [polypeptide binding]; other site
1194085006009	Walker A motif; other site
1194085006010	ATP binding site [chemical binding]; other site
1194085006011	Walker B motif; other site
1194085006012	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1194085006013	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1194085006014	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1194085006015	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
1194085006016	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1194085006017	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1194085006018	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1194085006019	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1194085006020	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1194085006021	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1194085006022	active site
1194085006023	homodimer interface [polypeptide binding]; other site
1194085006024	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1194085006025	active site
1194085006026	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1194085006027	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1194085006028	dimer interface [polypeptide binding]; other site
1194085006029	active site
1194085006030	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1194085006031	folate binding site [chemical binding]; other site
1194085006032	hypothetical protein; Provisional; Region: PRK13690
1194085006033	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1194085006034	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1194085006035	active site
1194085006036	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1194085006037	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1194085006038	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1194085006039	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085006040	S-adenosylmethionine binding site [chemical binding]; other site
1194085006041	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1194085006042	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1194085006043	RF-1 domain; Region: RF-1; pfam00472
1194085006044	thymidine kinase; Provisional; Region: PRK04296
1194085006045	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1194085006046	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1194085006047	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1194085006048	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1194085006049	RNA binding site [nucleotide binding]; other site
1194085006050	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1194085006051	multimer interface [polypeptide binding]; other site
1194085006052	Walker A motif; other site
1194085006053	ATP binding site [chemical binding]; other site
1194085006054	Walker B motif; other site
1194085006055	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1194085006056	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1194085006057	NAD binding site [chemical binding]; other site
1194085006058	catalytic residues [active]
1194085006059	Predicted transcriptional regulators [Transcription]; Region: COG1733
1194085006060	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1194085006061	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1194085006062	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1194085006063	hinge; other site
1194085006064	active site
1194085006065	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1194085006066	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1194085006067	intersubunit interface [polypeptide binding]; other site
1194085006068	active site
1194085006069	zinc binding site [ion binding]; other site
1194085006070	Na+ binding site [ion binding]; other site
1194085006071	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1194085006072	CTP synthetase; Validated; Region: pyrG; PRK05380
1194085006073	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1194085006074	Catalytic site [active]
1194085006075	active site
1194085006076	UTP binding site [chemical binding]; other site
1194085006077	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1194085006078	active site
1194085006079	putative oxyanion hole; other site
1194085006080	catalytic triad [active]
1194085006081	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1194085006082	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1194085006083	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085006084	Coenzyme A binding pocket [chemical binding]; other site
1194085006085	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1194085006086	Coenzyme A binding pocket [chemical binding]; other site
1194085006087	pantothenate kinase; Provisional; Region: PRK13317
1194085006088	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
1194085006089	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1194085006090	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1194085006091	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1194085006092	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1194085006093	metal binding site [ion binding]; metal-binding site
1194085006094	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1194085006095	Predicted membrane protein [Function unknown]; Region: COG4270
1194085006096	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1194085006097	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1194085006098	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1194085006099	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1194085006100	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1194085006101	intersubunit interface [polypeptide binding]; other site
1194085006102	active site
1194085006103	catalytic residue [active]
1194085006104	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1194085006105	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1194085006106	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1194085006107	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1194085006108	dimerization interface [polypeptide binding]; other site
1194085006109	DPS ferroxidase diiron center [ion binding]; other site
1194085006110	ion pore; other site
1194085006111	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1194085006112	EVE domain; Region: EVE; cl00728
1194085006113	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1194085006114	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1194085006115	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1194085006116	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1194085006117	NAD(P) binding site [chemical binding]; other site
1194085006118	putative active site [active]
1194085006119	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1194085006120	dimerization interface [polypeptide binding]; other site
1194085006121	putative DNA binding site [nucleotide binding]; other site
1194085006122	putative Zn2+ binding site [ion binding]; other site
1194085006123	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1194085006124	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1194085006125	SAP domain; Region: SAP; pfam02037
1194085006126	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1194085006127	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085006128	active site
1194085006129	motif I; other site
1194085006130	motif II; other site
1194085006131	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085006132	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1194085006133	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085006134	Walker A/P-loop; other site
1194085006135	ATP binding site [chemical binding]; other site
1194085006136	Q-loop/lid; other site
1194085006137	ABC transporter signature motif; other site
1194085006138	Walker B; other site
1194085006139	D-loop; other site
1194085006140	H-loop/switch region; other site
1194085006141	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1194085006142	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1194085006143	glutaminase active site [active]
1194085006144	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1194085006145	dimer interface [polypeptide binding]; other site
1194085006146	active site
1194085006147	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1194085006148	dimer interface [polypeptide binding]; other site
1194085006149	active site
1194085006150	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1194085006151	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1194085006152	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1194085006153	active site
1194085006154	P-loop; other site
1194085006155	phosphorylation site [posttranslational modification]
1194085006156	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1194085006157	HTH domain; Region: HTH_11; pfam08279
1194085006158	Mga helix-turn-helix domain; Region: Mga; pfam05043
1194085006159	PRD domain; Region: PRD; pfam00874
1194085006160	PRD domain; Region: PRD; pfam00874
1194085006161	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1194085006162	active site
1194085006163	P-loop; other site
1194085006164	phosphorylation site [posttranslational modification]
1194085006165	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1194085006166	active site
1194085006167	phosphorylation site [posttranslational modification]
1194085006168	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1194085006169	active site
1194085006170	phosphorylation site [posttranslational modification]
1194085006171	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1194085006172	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1194085006173	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1194085006174	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1194085006175	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1194085006176	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085006177	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085006178	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085006179	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085006180	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085006181	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085006182	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085006183	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085006184	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1194085006185	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1194085006186	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1194085006187	active site
1194085006188	substrate binding site [chemical binding]; other site
1194085006189	metal binding site [ion binding]; metal-binding site
1194085006190	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1194085006191	YbbR-like protein; Region: YbbR; pfam07949
1194085006192	YbbR-like protein; Region: YbbR; pfam07949
1194085006193	TIGR00159 family protein; Region: TIGR00159
1194085006194	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1194085006195	Arginase family; Region: Arginase; cd09989
1194085006196	active site
1194085006197	Mn binding site [ion binding]; other site
1194085006198	oligomer interface [polypeptide binding]; other site
1194085006199	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1194085006200	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1194085006201	Walker A motif; other site
1194085006202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006203	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085006204	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006205	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1194085006206	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
1194085006207	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
1194085006208	substrate binding site; other site
1194085006209	dimerization interface; other site
1194085006210	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1194085006211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1194085006212	Nucleoside recognition; Region: Gate; pfam07670
1194085006213	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1194085006214	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085006215	ABC-ATPase subunit  interface; other site
1194085006216	dimer interface [polypeptide binding]; other site
1194085006217	putative PBP binding regions; other site
1194085006218	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1194085006219	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1194085006220	ABC-ATPase subunit  interface; other site
1194085006221	dimer interface [polypeptide binding]; other site
1194085006222	putative PBP binding regions; other site
1194085006223	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1194085006224	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1194085006225	siderophore binding site; other site
1194085006226	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
1194085006227	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
1194085006228	dimer interface [polypeptide binding]; other site
1194085006229	active site
1194085006230	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1194085006231	substrate binding site [chemical binding]; other site
1194085006232	catalytic residue [active]
1194085006233	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1194085006234	IucA / IucC family; Region: IucA_IucC; pfam04183
1194085006235	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1194085006236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006237	putative substrate translocation pore; other site
1194085006238	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1194085006239	IucA / IucC family; Region: IucA_IucC; pfam04183
1194085006240	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1194085006241	Asp23 family; Region: Asp23; pfam03780
1194085006242	Small integral membrane protein [Function unknown]; Region: COG5547
1194085006243	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1194085006244	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1194085006245	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1194085006246	putative NAD(P) binding site [chemical binding]; other site
1194085006247	dimer interface [polypeptide binding]; other site
1194085006248	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1194085006249	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1194085006250	NAD(P) binding site [chemical binding]; other site
1194085006251	substrate binding site [chemical binding]; other site
1194085006252	dimer interface [polypeptide binding]; other site
1194085006253	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
1194085006254	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1194085006255	beta-galactosidase; Region: BGL; TIGR03356
1194085006256	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
1194085006257	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1194085006258	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1194085006259	active site
1194085006260	P-loop; other site
1194085006261	phosphorylation site [posttranslational modification]
1194085006262	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1194085006263	methionine cluster; other site
1194085006264	active site
1194085006265	phosphorylation site [posttranslational modification]
1194085006266	metal binding site [ion binding]; metal-binding site
1194085006267	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1194085006268	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1194085006269	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1194085006270	putative substrate binding site [chemical binding]; other site
1194085006271	putative ATP binding site [chemical binding]; other site
1194085006272	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1194085006273	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
1194085006274	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1194085006275	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1194085006276	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1194085006277	NAD-dependent deacetylase; Provisional; Region: PRK00481
1194085006278	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
1194085006279	NAD+ binding site [chemical binding]; other site
1194085006280	substrate binding site [chemical binding]; other site
1194085006281	putative Zn binding site [ion binding]; other site
1194085006282	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1194085006283	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1194085006284	active site
1194085006285	catalytic tetrad [active]
1194085006286	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1194085006287	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1194085006288	DNA binding residues [nucleotide binding]
1194085006289	putative dimer interface [polypeptide binding]; other site
1194085006290	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1194085006291	substrate binding site [chemical binding]; other site
1194085006292	catalytic residues [active]
1194085006293	Predicted transcriptional regulator [Transcription]; Region: COG2378
1194085006294	HTH domain; Region: HTH_11; pfam08279
1194085006295	WYL domain; Region: WYL; pfam13280
1194085006296	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1194085006297	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1194085006298	conserved cys residue [active]
1194085006299	MAP domain; Region: MAP; pfam03642
1194085006300	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1194085006301	acetolactate synthase; Reviewed; Region: PRK08617
1194085006302	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1194085006303	PYR/PP interface [polypeptide binding]; other site
1194085006304	dimer interface [polypeptide binding]; other site
1194085006305	TPP binding site [chemical binding]; other site
1194085006306	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1194085006307	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1194085006308	TPP-binding site [chemical binding]; other site
1194085006309	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
1194085006310	Divergent AAA domain; Region: AAA_4; pfam04326
1194085006311	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1194085006312	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1194085006313	putative DNA binding site [nucleotide binding]; other site
1194085006314	putative Zn2+ binding site [ion binding]; other site
1194085006315	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1194085006316	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1194085006317	23S rRNA interface [nucleotide binding]; other site
1194085006318	L3 interface [polypeptide binding]; other site
1194085006319	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1194085006320	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1194085006321	dimerization interface 3.5A [polypeptide binding]; other site
1194085006322	active site
1194085006323	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1194085006324	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
1194085006325	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1194085006326	Walker A/P-loop; other site
1194085006327	ATP binding site [chemical binding]; other site
1194085006328	Q-loop/lid; other site
1194085006329	ABC transporter signature motif; other site
1194085006330	Walker B; other site
1194085006331	D-loop; other site
1194085006332	H-loop/switch region; other site
1194085006333	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
1194085006334	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1194085006335	Walker A/P-loop; other site
1194085006336	ATP binding site [chemical binding]; other site
1194085006337	Q-loop/lid; other site
1194085006338	ABC transporter signature motif; other site
1194085006339	Walker B; other site
1194085006340	D-loop; other site
1194085006341	H-loop/switch region; other site
1194085006342	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1194085006343	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1194085006344	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1194085006345	alphaNTD homodimer interface [polypeptide binding]; other site
1194085006346	alphaNTD - beta interaction site [polypeptide binding]; other site
1194085006347	alphaNTD - beta' interaction site [polypeptide binding]; other site
1194085006348	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1194085006349	30S ribosomal protein S11; Validated; Region: PRK05309
1194085006350	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1194085006351	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1194085006352	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1194085006353	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1194085006354	rRNA binding site [nucleotide binding]; other site
1194085006355	predicted 30S ribosome binding site; other site
1194085006356	adenylate kinase; Reviewed; Region: adk; PRK00279
1194085006357	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1194085006358	AMP-binding site [chemical binding]; other site
1194085006359	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1194085006360	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1194085006361	SecY translocase; Region: SecY; pfam00344
1194085006362	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1194085006363	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1194085006364	23S rRNA binding site [nucleotide binding]; other site
1194085006365	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
1194085006366	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1194085006367	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1194085006368	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1194085006369	5S rRNA interface [nucleotide binding]; other site
1194085006370	L27 interface [polypeptide binding]; other site
1194085006371	23S rRNA interface [nucleotide binding]; other site
1194085006372	L5 interface [polypeptide binding]; other site
1194085006373	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1194085006374	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1194085006375	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1194085006376	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1194085006377	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1194085006378	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1194085006379	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1194085006380	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1194085006381	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1194085006382	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1194085006383	RNA binding site [nucleotide binding]; other site
1194085006384	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1194085006385	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1194085006386	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1194085006387	23S rRNA interface [nucleotide binding]; other site
1194085006388	putative translocon interaction site; other site
1194085006389	signal recognition particle (SRP54) interaction site; other site
1194085006390	L23 interface [polypeptide binding]; other site
1194085006391	trigger factor interaction site; other site
1194085006392	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1194085006393	23S rRNA interface [nucleotide binding]; other site
1194085006394	5S rRNA interface [nucleotide binding]; other site
1194085006395	putative antibiotic binding site [chemical binding]; other site
1194085006396	L25 interface [polypeptide binding]; other site
1194085006397	L27 interface [polypeptide binding]; other site
1194085006398	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1194085006399	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1194085006400	G-X-X-G motif; other site
1194085006401	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1194085006402	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1194085006403	putative translocon binding site; other site
1194085006404	protein-rRNA interface [nucleotide binding]; other site
1194085006405	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1194085006406	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1194085006407	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1194085006408	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1194085006409	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1194085006410	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1194085006411	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1194085006412	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1194085006413	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1194085006414	DNA topoisomerase III; Provisional; Region: PRK07726
1194085006415	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1194085006416	active site
1194085006417	putative interdomain interaction site [polypeptide binding]; other site
1194085006418	putative metal-binding site [ion binding]; other site
1194085006419	putative nucleotide binding site [chemical binding]; other site
1194085006420	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1194085006421	domain I; other site
1194085006422	DNA binding groove [nucleotide binding]
1194085006423	phosphate binding site [ion binding]; other site
1194085006424	domain II; other site
1194085006425	domain III; other site
1194085006426	nucleotide binding site [chemical binding]; other site
1194085006427	catalytic site [active]
1194085006428	domain IV; other site
1194085006429	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1194085006430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085006431	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1194085006432	Coenzyme A binding pocket [chemical binding]; other site
1194085006433	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1194085006434	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1194085006435	Predicted permeases [General function prediction only]; Region: COG0679
1194085006436	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1194085006437	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1194085006438	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1194085006439	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1194085006440	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1194085006441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006442	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085006443	putative substrate translocation pore; other site
1194085006444	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085006445	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1194085006446	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1194085006447	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085006448	FeS/SAM binding site; other site
1194085006449	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1194085006450	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1194085006451	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1194085006452	GTP binding site; other site
1194085006453	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1194085006454	MoaE interaction surface [polypeptide binding]; other site
1194085006455	MoeB interaction surface [polypeptide binding]; other site
1194085006456	thiocarboxylated glycine; other site
1194085006457	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1194085006458	MoaE homodimer interface [polypeptide binding]; other site
1194085006459	MoaD interaction [polypeptide binding]; other site
1194085006460	active site residues [active]
1194085006461	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
1194085006462	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1194085006463	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1194085006464	dimer interface [polypeptide binding]; other site
1194085006465	putative functional site; other site
1194085006466	putative MPT binding site; other site
1194085006467	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1194085006468	trimer interface [polypeptide binding]; other site
1194085006469	dimer interface [polypeptide binding]; other site
1194085006470	putative active site [active]
1194085006471	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1194085006472	MPT binding site; other site
1194085006473	trimer interface [polypeptide binding]; other site
1194085006474	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1194085006475	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1194085006476	ATP binding site [chemical binding]; other site
1194085006477	substrate interface [chemical binding]; other site
1194085006478	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085006479	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1194085006480	Walker A/P-loop; other site
1194085006481	ATP binding site [chemical binding]; other site
1194085006482	Q-loop/lid; other site
1194085006483	ABC transporter signature motif; other site
1194085006484	Walker B; other site
1194085006485	D-loop; other site
1194085006486	H-loop/switch region; other site
1194085006487	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1194085006488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085006489	dimer interface [polypeptide binding]; other site
1194085006490	conserved gate region; other site
1194085006491	putative PBP binding loops; other site
1194085006492	ABC-ATPase subunit interface; other site
1194085006493	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1194085006494	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1194085006495	substrate binding pocket [chemical binding]; other site
1194085006496	membrane-bound complex binding site; other site
1194085006497	hinge residues; other site
1194085006498	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1194085006499	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085006500	Coenzyme A binding pocket [chemical binding]; other site
1194085006501	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1194085006502	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
1194085006503	active site
1194085006504	dimerization interface [polypeptide binding]; other site
1194085006505	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1194085006506	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1194085006507	intersubunit interface [polypeptide binding]; other site
1194085006508	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1194085006509	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1194085006510	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
1194085006511	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1194085006512	alpha-gamma subunit interface [polypeptide binding]; other site
1194085006513	beta-gamma subunit interface [polypeptide binding]; other site
1194085006514	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1194085006515	gamma-beta subunit interface [polypeptide binding]; other site
1194085006516	alpha-beta subunit interface [polypeptide binding]; other site
1194085006517	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1194085006518	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1194085006519	subunit interactions [polypeptide binding]; other site
1194085006520	active site
1194085006521	flap region; other site
1194085006522	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1194085006523	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1194085006524	dimer interface [polypeptide binding]; other site
1194085006525	catalytic residues [active]
1194085006526	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1194085006527	UreF; Region: UreF; pfam01730
1194085006528	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1194085006529	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1194085006530	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085006531	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085006532	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085006533	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1194085006534	Helix-turn-helix domain; Region: HTH_18; pfam12833
1194085006535	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1194085006536	Surface antigen [General function prediction only]; Region: COG3942
1194085006537	CHAP domain; Region: CHAP; pfam05257
1194085006538	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1194085006539	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1194085006540	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1194085006541	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1194085006542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
1194085006543	Surface antigen [General function prediction only]; Region: COG3942
1194085006544	CHAP domain; Region: CHAP; pfam05257
1194085006545	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1194085006546	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1194085006547	putative ligand binding site [chemical binding]; other site
1194085006548	putative NAD binding site [chemical binding]; other site
1194085006549	catalytic site [active]
1194085006550	hypothetical protein; Provisional; Region: PRK06753
1194085006551	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1194085006552	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1194085006553	Lysozyme subfamily 2; Region: LYZ2; smart00047
1194085006554	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1194085006555	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1194085006556	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1194085006557	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1194085006558	4Fe-4S binding domain; Region: Fer4; pfam00037
1194085006559	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1194085006560	[4Fe-4S] binding site [ion binding]; other site
1194085006561	molybdopterin cofactor binding site; other site
1194085006562	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1194085006563	molybdopterin cofactor binding site; other site
1194085006564	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1194085006565	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1194085006566	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1194085006567	active site
1194085006568	Predicted transcriptional regulator [Transcription]; Region: COG2378
1194085006569	HTH domain; Region: HTH_11; pfam08279
1194085006570	CAAX protease self-immunity; Region: Abi; pfam02517
1194085006571	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1194085006572	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1194085006573	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1194085006574	putative active site [active]
1194085006575	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1194085006576	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1194085006577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085006578	active site
1194085006579	motif I; other site
1194085006580	motif II; other site
1194085006581	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1194085006582	Sodium Bile acid symporter family; Region: SBF; pfam01758
1194085006583	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1194085006584	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1194085006585	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1194085006586	active site turn [active]
1194085006587	phosphorylation site [posttranslational modification]
1194085006588	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1194085006589	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1194085006590	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1194085006591	putative active site [active]
1194085006592	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1194085006593	putative hydrophobic ligand binding site [chemical binding]; other site
1194085006594	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1194085006595	oxidoreductase; Provisional; Region: PRK07985
1194085006596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1194085006597	NAD(P) binding site [chemical binding]; other site
1194085006598	active site
1194085006599	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1194085006600	amidohydrolase; Region: amidohydrolases; TIGR01891
1194085006601	metal binding site [ion binding]; metal-binding site
1194085006602	dimer interface [polypeptide binding]; other site
1194085006603	imidazolonepropionase; Validated; Region: PRK09356
1194085006604	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1194085006605	active site
1194085006606	urocanate hydratase; Provisional; Region: PRK05414
1194085006607	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1194085006608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1194085006609	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1194085006610	dimerization interface [polypeptide binding]; other site
1194085006611	formimidoylglutamase; Provisional; Region: PRK13775
1194085006612	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1194085006613	putative active site [active]
1194085006614	putative metal binding site [ion binding]; other site
1194085006615	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1194085006616	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1194085006617	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1194085006618	active site
1194085006619	dimer interface [polypeptide binding]; other site
1194085006620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1194085006621	MOSC domain; Region: MOSC; pfam03473
1194085006622	3-alpha domain; Region: 3-alpha; pfam03475
1194085006623	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1194085006624	active site
1194085006625	catalytic residues [active]
1194085006626	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1194085006627	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1194085006628	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085006629	Walker A/P-loop; other site
1194085006630	ATP binding site [chemical binding]; other site
1194085006631	Q-loop/lid; other site
1194085006632	ABC transporter signature motif; other site
1194085006633	Walker B; other site
1194085006634	D-loop; other site
1194085006635	H-loop/switch region; other site
1194085006636	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1194085006637	Predicted membrane protein [Function unknown]; Region: COG3152
1194085006638	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1194085006639	active site
1194085006640	DNA binding site [nucleotide binding]
1194085006641	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
1194085006642	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1194085006643	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1194085006644	homotetramer interface [polypeptide binding]; other site
1194085006645	FMN binding site [chemical binding]; other site
1194085006646	homodimer contacts [polypeptide binding]; other site
1194085006647	putative active site [active]
1194085006648	putative substrate binding site [chemical binding]; other site
1194085006649	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1194085006650	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1194085006651	oligomer interface [polypeptide binding]; other site
1194085006652	metal binding site [ion binding]; metal-binding site
1194085006653	metal binding site [ion binding]; metal-binding site
1194085006654	putative Cl binding site [ion binding]; other site
1194085006655	aspartate ring; other site
1194085006656	basic sphincter; other site
1194085006657	hydrophobic gate; other site
1194085006658	periplasmic entrance; other site
1194085006659	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1194085006660	active site
1194085006661	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1194085006662	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1194085006663	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006664	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1194085006665	putative substrate translocation pore; other site
1194085006666	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1194085006667	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1194085006668	lipoyl-biotinyl attachment site [posttranslational modification]; other site
1194085006669	HlyD family secretion protein; Region: HlyD_3; pfam13437
1194085006670	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085006671	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085006672	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1194085006673	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085006674	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1194085006675	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006676	putative substrate translocation pore; other site
1194085006677	Predicted membrane protein [Function unknown]; Region: COG4640
1194085006678	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1194085006679	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1194085006680	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1194085006681	putative Zn2+ binding site [ion binding]; other site
1194085006682	putative DNA binding site [nucleotide binding]; other site
1194085006683	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1194085006684	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1194085006685	putative active site [active]
1194085006686	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1194085006687	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1194085006688	Walker A/P-loop; other site
1194085006689	ATP binding site [chemical binding]; other site
1194085006690	Q-loop/lid; other site
1194085006691	ABC transporter signature motif; other site
1194085006692	Walker B; other site
1194085006693	D-loop; other site
1194085006694	H-loop/switch region; other site
1194085006695	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1194085006696	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1194085006697	FtsX-like permease family; Region: FtsX; pfam02687
1194085006698	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1194085006699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085006700	active site
1194085006701	phosphorylation site [posttranslational modification]
1194085006702	intermolecular recognition site; other site
1194085006703	dimerization interface [polypeptide binding]; other site
1194085006704	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1194085006705	DNA binding site [nucleotide binding]
1194085006706	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1194085006707	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1194085006708	dimerization interface [polypeptide binding]; other site
1194085006709	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1194085006710	dimer interface [polypeptide binding]; other site
1194085006711	phosphorylation site [posttranslational modification]
1194085006712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085006713	ATP binding site [chemical binding]; other site
1194085006714	Mg2+ binding site [ion binding]; other site
1194085006715	G-X-G motif; other site
1194085006716	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1194085006717	LytTr DNA-binding domain; Region: LytTR; smart00850
1194085006718	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1194085006719	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1194085006720	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1194085006721	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
1194085006722	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1194085006723	Walker A/P-loop; other site
1194085006724	ATP binding site [chemical binding]; other site
1194085006725	Q-loop/lid; other site
1194085006726	ABC transporter signature motif; other site
1194085006727	Walker B; other site
1194085006728	D-loop; other site
1194085006729	H-loop/switch region; other site
1194085006730	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1194085006731	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1194085006732	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
1194085006733	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1194085006734	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1194085006735	L-lactate permease; Region: Lactate_perm; cl00701
1194085006736	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1194085006737	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1194085006738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085006739	Coenzyme A binding pocket [chemical binding]; other site
1194085006740	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1194085006741	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1194085006742	NAD(P) binding site [chemical binding]; other site
1194085006743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085006744	Coenzyme A binding pocket [chemical binding]; other site
1194085006745	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1194085006746	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1194085006747	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085006748	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
1194085006749	Predicted membrane protein [Function unknown]; Region: COG1511
1194085006750	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1194085006751	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1194085006752	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1194085006753	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1194085006754	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1194085006755	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1194085006756	Cl binding site [ion binding]; other site
1194085006757	oligomer interface [polypeptide binding]; other site
1194085006758	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1194085006759	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1194085006760	active site turn [active]
1194085006761	phosphorylation site [posttranslational modification]
1194085006762	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1194085006763	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1194085006764	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1194085006765	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1194085006766	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1194085006767	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1194085006768	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1194085006769	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1194085006770	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
1194085006771	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1194085006772	MarR family; Region: MarR_2; pfam12802
1194085006773	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1194085006774	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1194085006775	putative dimer interface [polypeptide binding]; other site
1194085006776	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1194085006777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006778	putative substrate translocation pore; other site
1194085006779	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
1194085006780	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1194085006781	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1194085006782	DNA binding residues [nucleotide binding]
1194085006783	dimer interface [polypeptide binding]; other site
1194085006784	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1194085006785	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1194085006786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085006787	active site
1194085006788	phosphorylation site [posttranslational modification]
1194085006789	intermolecular recognition site; other site
1194085006790	dimerization interface [polypeptide binding]; other site
1194085006791	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1194085006792	DNA binding residues [nucleotide binding]
1194085006793	dimerization interface [polypeptide binding]; other site
1194085006794	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1194085006795	Histidine kinase; Region: HisKA_3; pfam07730
1194085006796	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085006797	ATP binding site [chemical binding]; other site
1194085006798	Mg2+ binding site [ion binding]; other site
1194085006799	G-X-G motif; other site
1194085006800	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1194085006801	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1194085006802	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1194085006803	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1194085006804	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1194085006805	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1194085006806	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1194085006807	[4Fe-4S] binding site [ion binding]; other site
1194085006808	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1194085006809	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1194085006810	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1194085006811	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1194085006812	molybdopterin cofactor binding site; other site
1194085006813	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1194085006814	active site
1194085006815	SAM binding site [chemical binding]; other site
1194085006816	homodimer interface [polypeptide binding]; other site
1194085006817	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1194085006818	[2Fe-2S] cluster binding site [ion binding]; other site
1194085006819	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1194085006820	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1194085006821	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1194085006822	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1194085006823	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1194085006824	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1194085006825	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1194085006826	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1194085006827	putative active site [active]
1194085006828	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1194085006829	active site
1194085006830	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1194085006831	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085006832	Coenzyme A binding pocket [chemical binding]; other site
1194085006833	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1194085006834	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1194085006835	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1194085006836	putative hydrophobic ligand binding site [chemical binding]; other site
1194085006837	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1194085006838	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1194085006839	intersubunit interface [polypeptide binding]; other site
1194085006840	YodA lipocalin-like domain; Region: YodA; pfam09223
1194085006841	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
1194085006842	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1194085006843	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1194085006844	Thioredoxin; Region: Thioredoxin_4; cl17273
1194085006845	FemAB family; Region: FemAB; pfam02388
1194085006846	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1194085006847	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1194085006848	Walker A/P-loop; other site
1194085006849	ATP binding site [chemical binding]; other site
1194085006850	Q-loop/lid; other site
1194085006851	ABC transporter signature motif; other site
1194085006852	Walker B; other site
1194085006853	D-loop; other site
1194085006854	H-loop/switch region; other site
1194085006855	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1194085006856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085006857	dimer interface [polypeptide binding]; other site
1194085006858	conserved gate region; other site
1194085006859	putative PBP binding loops; other site
1194085006860	ABC-ATPase subunit interface; other site
1194085006861	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1194085006862	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1194085006863	substrate binding pocket [chemical binding]; other site
1194085006864	membrane-bound complex binding site; other site
1194085006865	hinge residues; other site
1194085006866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006867	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085006868	putative substrate translocation pore; other site
1194085006869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006870	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1194085006871	catalytic core [active]
1194085006872	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1194085006873	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1194085006874	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1194085006875	B domain; Region: B; pfam02216
1194085006876	B domain; Region: B; pfam02216
1194085006877	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
1194085006878	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1194085006879	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1194085006880	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
1194085006881	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
1194085006882	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1194085006883	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1194085006884	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1194085006885	catalytic residue [active]
1194085006886	biotin synthase; Validated; Region: PRK06256
1194085006887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085006888	FeS/SAM binding site; other site
1194085006889	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1194085006890	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1194085006891	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1194085006892	inhibitor-cofactor binding pocket; inhibition site
1194085006893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085006894	catalytic residue [active]
1194085006895	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1194085006896	AAA domain; Region: AAA_26; pfam13500
1194085006897	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1194085006898	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1194085006899	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1194085006900	Walker A/P-loop; other site
1194085006901	ATP binding site [chemical binding]; other site
1194085006902	Q-loop/lid; other site
1194085006903	ABC transporter signature motif; other site
1194085006904	Walker B; other site
1194085006905	D-loop; other site
1194085006906	H-loop/switch region; other site
1194085006907	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1194085006908	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1194085006909	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085006910	Walker A/P-loop; other site
1194085006911	ATP binding site [chemical binding]; other site
1194085006912	Q-loop/lid; other site
1194085006913	ABC transporter signature motif; other site
1194085006914	Walker B; other site
1194085006915	D-loop; other site
1194085006916	H-loop/switch region; other site
1194085006917	Predicted membrane protein [Function unknown]; Region: COG2246
1194085006918	GtrA-like protein; Region: GtrA; pfam04138
1194085006919	glycerate kinase; Region: TIGR00045
1194085006920	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1194085006921	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1194085006922	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006923	putative substrate translocation pore; other site
1194085006924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1194085006925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990
1194085006926	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1194085006927	putative phosphoesterase; Region: acc_ester; TIGR03729
1194085006928	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1194085006929	Spore germination protein; Region: Spore_permease; cl17796
1194085006930	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1194085006931	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1194085006932	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1194085006933	Beta-lactamase; Region: Beta-lactamase; pfam00144
1194085006934	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1194085006935	extended (e) SDRs; Region: SDR_e; cd08946
1194085006936	NAD(P) binding site [chemical binding]; other site
1194085006937	active site
1194085006938	substrate binding site [chemical binding]; other site
1194085006939	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1194085006940	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1194085006941	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1194085006942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006943	putative substrate translocation pore; other site
1194085006944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085006946	dimer interface [polypeptide binding]; other site
1194085006947	conserved gate region; other site
1194085006948	putative PBP binding loops; other site
1194085006949	ABC-ATPase subunit interface; other site
1194085006950	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1194085006951	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1194085006952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085006953	dimer interface [polypeptide binding]; other site
1194085006954	conserved gate region; other site
1194085006955	putative PBP binding loops; other site
1194085006956	ABC-ATPase subunit interface; other site
1194085006957	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1194085006958	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1194085006959	Walker A/P-loop; other site
1194085006960	ATP binding site [chemical binding]; other site
1194085006961	Q-loop/lid; other site
1194085006962	ABC transporter signature motif; other site
1194085006963	Walker B; other site
1194085006964	D-loop; other site
1194085006965	H-loop/switch region; other site
1194085006966	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1194085006967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1194085006968	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1194085006969	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1194085006970	amino acid transporter; Region: 2A0306; TIGR00909
1194085006971	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1194085006972	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1194085006973	substrate binding pocket [chemical binding]; other site
1194085006974	catalytic triad [active]
1194085006975	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1194085006976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085006977	putative substrate translocation pore; other site
1194085006978	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1194085006979	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1194085006980	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1194085006981	Walker A/P-loop; other site
1194085006982	ATP binding site [chemical binding]; other site
1194085006983	Q-loop/lid; other site
1194085006984	ABC transporter signature motif; other site
1194085006985	Walker B; other site
1194085006986	D-loop; other site
1194085006987	H-loop/switch region; other site
1194085006988	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1194085006989	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1194085006990	oligomer interface [polypeptide binding]; other site
1194085006991	active site
1194085006992	metal binding site [ion binding]; metal-binding site
1194085006993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
1194085006994	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1194085006995	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1194085006996	active site
1194085006997	FMN binding site [chemical binding]; other site
1194085006998	substrate binding site [chemical binding]; other site
1194085006999	3Fe-4S cluster binding site [ion binding]; other site
1194085007000	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085007001	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1194085007002	putative substrate translocation pore; other site
1194085007003	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1194085007004	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085007005	Walker A/P-loop; other site
1194085007006	ATP binding site [chemical binding]; other site
1194085007007	Q-loop/lid; other site
1194085007008	ABC transporter signature motif; other site
1194085007009	Walker B; other site
1194085007010	D-loop; other site
1194085007011	H-loop/switch region; other site
1194085007012	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1194085007013	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1194085007014	Walker A/P-loop; other site
1194085007015	ATP binding site [chemical binding]; other site
1194085007016	Q-loop/lid; other site
1194085007017	ABC transporter signature motif; other site
1194085007018	Walker B; other site
1194085007019	D-loop; other site
1194085007020	H-loop/switch region; other site
1194085007021	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1194085007022	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1194085007023	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1194085007024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085007025	dimer interface [polypeptide binding]; other site
1194085007026	conserved gate region; other site
1194085007027	putative PBP binding loops; other site
1194085007028	ABC-ATPase subunit interface; other site
1194085007029	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1194085007030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1194085007031	dimer interface [polypeptide binding]; other site
1194085007032	conserved gate region; other site
1194085007033	putative PBP binding loops; other site
1194085007034	ABC-ATPase subunit interface; other site
1194085007035	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1194085007036	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1194085007037	substrate binding site [chemical binding]; other site
1194085007038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
1194085007039	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
1194085007040	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1194085007041	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1194085007042	short chain dehydrogenase; Validated; Region: PRK08589
1194085007043	classical (c) SDRs; Region: SDR_c; cd05233
1194085007044	NAD(P) binding site [chemical binding]; other site
1194085007045	active site
1194085007046	AbgT putative transporter family; Region: ABG_transport; cl17431
1194085007047	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1194085007048	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1194085007049	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1194085007050	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1194085007051	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1194085007052	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1194085007053	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1194085007054	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1194085007055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1194085007056	NAD(P) binding site [chemical binding]; other site
1194085007057	active site
1194085007058	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
1194085007059	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085007060	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085007061	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085007062	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085007063	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1194085007064	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
1194085007065	PLD-like domain; Region: PLDc_2; pfam13091
1194085007066	putative homodimer interface [polypeptide binding]; other site
1194085007067	putative active site [active]
1194085007068	catalytic site [active]
1194085007069	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1194085007070	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1194085007071	ATP binding site [chemical binding]; other site
1194085007072	putative Mg++ binding site [ion binding]; other site
1194085007073	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1194085007074	nucleotide binding region [chemical binding]; other site
1194085007075	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1194085007076	ATP-binding site [chemical binding]; other site
1194085007077	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1194085007078	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1194085007079	active site
1194085007080	8-oxo-dGMP binding site [chemical binding]; other site
1194085007081	nudix motif; other site
1194085007082	metal binding site [ion binding]; metal-binding site
1194085007083	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1194085007084	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1194085007085	active site
1194085007086	substrate binding site [chemical binding]; other site
1194085007087	metal binding site [ion binding]; metal-binding site
1194085007088	H+ Antiporter protein; Region: 2A0121; TIGR00900
1194085007089	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085007090	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1194085007091	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085007092	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1194085007093	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1194085007094	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1194085007095	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1194085007096	active site
1194085007097	tetramer interface; other site
1194085007098	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1194085007099	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1194085007100	GntP family permease; Region: GntP_permease; pfam02447
1194085007101	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1194085007102	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1194085007103	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1194085007104	N- and C-terminal domain interface [polypeptide binding]; other site
1194085007105	active site
1194085007106	catalytic site [active]
1194085007107	metal binding site [ion binding]; metal-binding site
1194085007108	carbohydrate binding site [chemical binding]; other site
1194085007109	ATP binding site [chemical binding]; other site
1194085007110	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1194085007111	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1194085007112	DNA-binding site [nucleotide binding]; DNA binding site
1194085007113	FCD domain; Region: FCD; pfam07729
1194085007114	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1194085007115	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1194085007116	DNA binding residues [nucleotide binding]
1194085007117	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1194085007118	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1194085007119	synthetase active site [active]
1194085007120	NTP binding site [chemical binding]; other site
1194085007121	metal binding site [ion binding]; metal-binding site
1194085007122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1194085007123	Predicted membrane protein [Function unknown]; Region: COG1289
1194085007124	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1194085007125	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1194085007126	D-galactonate transporter; Region: 2A0114; TIGR00893
1194085007127	putative substrate translocation pore; other site
1194085007128	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1194085007129	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1194085007130	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1194085007131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085007132	Walker A/P-loop; other site
1194085007133	ATP binding site [chemical binding]; other site
1194085007134	Q-loop/lid; other site
1194085007135	ABC transporter signature motif; other site
1194085007136	Walker B; other site
1194085007137	D-loop; other site
1194085007138	H-loop/switch region; other site
1194085007139	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1194085007140	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1194085007141	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1194085007142	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
1194085007143	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1194085007144	putative NAD(P) binding site [chemical binding]; other site
1194085007145	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1194085007146	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1194085007147	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1194085007148	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1194085007149	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1194085007150	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085007151	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1194085007152	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1194085007153	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
1194085007154	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1194085007155	Predicted esterase [General function prediction only]; Region: COG0400
1194085007156	putative hydrolase; Provisional; Region: PRK11460
1194085007157	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1194085007158	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1194085007159	Zn binding site [ion binding]; other site
1194085007160	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1194085007161	Zn binding site [ion binding]; other site
1194085007162	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1194085007163	MarR family; Region: MarR; pfam01047
1194085007164	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1194085007165	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1194085007166	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1194085007167	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1194085007168	putative metal binding site [ion binding]; other site
1194085007169	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1194085007170	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1194085007171	dimer interface [polypeptide binding]; other site
1194085007172	FMN binding site [chemical binding]; other site
1194085007173	D-lactate dehydrogenase; Provisional; Region: PRK12480
1194085007174	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1194085007175	homodimer interface [polypeptide binding]; other site
1194085007176	ligand binding site [chemical binding]; other site
1194085007177	NAD binding site [chemical binding]; other site
1194085007178	catalytic site [active]
1194085007179	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1194085007180	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1194085007181	active site
1194085007182	motif I; other site
1194085007183	motif II; other site
1194085007184	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1194085007185	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1194085007186	Walker A/P-loop; other site
1194085007187	ATP binding site [chemical binding]; other site
1194085007188	Q-loop/lid; other site
1194085007189	ABC transporter signature motif; other site
1194085007190	Walker B; other site
1194085007191	D-loop; other site
1194085007192	H-loop/switch region; other site
1194085007193	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
1194085007194	active site
1194085007195	catalytic site [active]
1194085007196	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1194085007197	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085007198	Coenzyme A binding pocket [chemical binding]; other site
1194085007199	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1194085007200	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1194085007201	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1194085007202	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1194085007203	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1194085007204	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1194085007205	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1194085007206	EamA-like transporter family; Region: EamA; pfam00892
1194085007207	EamA-like transporter family; Region: EamA; pfam00892
1194085007208	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1194085007209	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1194085007210	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1194085007211	catalytic residues [active]
1194085007212	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1194085007213	active site
1194085007214	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1194085007215	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1194085007216	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1194085007217	active site turn [active]
1194085007218	phosphorylation site [posttranslational modification]
1194085007219	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1194085007220	HPr interaction site; other site
1194085007221	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1194085007222	active site
1194085007223	phosphorylation site [posttranslational modification]
1194085007224	pyruvate oxidase; Provisional; Region: PRK08611
1194085007225	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1194085007226	PYR/PP interface [polypeptide binding]; other site
1194085007227	tetramer interface [polypeptide binding]; other site
1194085007228	dimer interface [polypeptide binding]; other site
1194085007229	TPP binding site [chemical binding]; other site
1194085007230	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1194085007231	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1194085007232	TPP-binding site [chemical binding]; other site
1194085007233	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1194085007234	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1194085007235	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1194085007236	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1194085007237	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1194085007238	putative dimerization interface [polypeptide binding]; other site
1194085007239	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1194085007240	Surface antigen [General function prediction only]; Region: COG3942
1194085007241	CHAP domain; Region: CHAP; pfam05257
1194085007242	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1194085007243	homodimer interface [polypeptide binding]; other site
1194085007244	catalytic residues [active]
1194085007245	NAD binding site [chemical binding]; other site
1194085007246	substrate binding pocket [chemical binding]; other site
1194085007247	flexible flap; other site
1194085007248	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1194085007249	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1194085007250	dimer interface [polypeptide binding]; other site
1194085007251	active site
1194085007252	superantigen-like protein; Reviewed; Region: PRK13037
1194085007253	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1194085007254	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1194085007255	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1194085007256	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1194085007257	DNA binding site [nucleotide binding]
1194085007258	active site
1194085007259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085007260	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1194085007261	Walker A motif; other site
1194085007262	ATP binding site [chemical binding]; other site
1194085007263	Walker B motif; other site
1194085007264	arginine finger; other site
1194085007265	UvrB/uvrC motif; Region: UVR; pfam02151
1194085007266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1194085007267	Walker A motif; other site
1194085007268	ATP binding site [chemical binding]; other site
1194085007269	Walker B motif; other site
1194085007270	arginine finger; other site
1194085007271	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1194085007272	Virus attachment protein p12 family; Region: P12; pfam12669
1194085007273	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1194085007274	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1194085007275	G1 box; other site
1194085007276	GTP/Mg2+ binding site [chemical binding]; other site
1194085007277	Switch I region; other site
1194085007278	G2 box; other site
1194085007279	G3 box; other site
1194085007280	Switch II region; other site
1194085007281	G4 box; other site
1194085007282	G5 box; other site
1194085007283	Nucleoside recognition; Region: Gate; pfam07670
1194085007284	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1194085007285	Nucleoside recognition; Region: Gate; pfam07670
1194085007286	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1194085007287	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1194085007288	Protein export membrane protein; Region: SecD_SecF; cl14618
1194085007289	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1194085007290	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1194085007291	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1194085007292	Glutamate binding site [chemical binding]; other site
1194085007293	homodimer interface [polypeptide binding]; other site
1194085007294	NAD binding site [chemical binding]; other site
1194085007295	catalytic residues [active]
1194085007296	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
1194085007297	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1194085007298	active site
1194085007299	substrate binding site [chemical binding]; other site
1194085007300	trimer interface [polypeptide binding]; other site
1194085007301	CoA binding site [chemical binding]; other site
1194085007302	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1194085007303	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1194085007304	metal-binding site [ion binding]
1194085007305	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1194085007306	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1194085007307	metal-binding site [ion binding]
1194085007308	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1194085007309	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1194085007310	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1194085007311	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1194085007312	metal-binding site [ion binding]
1194085007313	D-lactate dehydrogenase; Validated; Region: PRK08605
1194085007314	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1194085007315	homodimer interface [polypeptide binding]; other site
1194085007316	ligand binding site [chemical binding]; other site
1194085007317	NAD binding site [chemical binding]; other site
1194085007318	catalytic site [active]
1194085007319	transaminase; Reviewed; Region: PRK08068
1194085007320	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1194085007321	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085007322	homodimer interface [polypeptide binding]; other site
1194085007323	catalytic residue [active]
1194085007324	phytoene desaturase; Region: crtI_fam; TIGR02734
1194085007325	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1194085007326	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1194085007327	active site lid residues [active]
1194085007328	substrate binding pocket [chemical binding]; other site
1194085007329	catalytic residues [active]
1194085007330	substrate-Mg2+ binding site; other site
1194085007331	aspartate-rich region 1; other site
1194085007332	aspartate-rich region 2; other site
1194085007333	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1194085007334	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1194085007335	active site
1194085007336	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1194085007337	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1194085007338	Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237
1194085007339	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1194085007340	Surface antigen [General function prediction only]; Region: COG3942
1194085007341	CHAP domain; Region: CHAP; pfam05257
1194085007342	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1194085007343	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1194085007344	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1194085007345	catalytic triad [active]
1194085007346	catalytic triad [active]
1194085007347	oxyanion hole [active]
1194085007348	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085007349	Coenzyme A binding pocket [chemical binding]; other site
1194085007350	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1194085007351	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1194085007352	catalytic residue [active]
1194085007353	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1194085007354	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1194085007355	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1194085007356	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1194085007357	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
1194085007358	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1194085007359	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1194085007360	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1194085007361	NmrA-like family; Region: NmrA; pfam05368
1194085007362	NADP binding site [chemical binding]; other site
1194085007363	active site
1194085007364	regulatory binding site [polypeptide binding]; other site
1194085007365	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367
1194085007366	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1194085007367	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1194085007368	short chain dehydrogenase; Provisional; Region: PRK12937
1194085007369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1194085007370	NAD(P) binding site [chemical binding]; other site
1194085007371	active site
1194085007372	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1194085007373	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1194085007374	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1194085007375	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1194085007376	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1194085007377	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1194085007378	Nucleoside recognition; Region: Gate; pfam07670
1194085007379	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1194085007380	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1194085007381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
1194085007382	valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419
1194085007383	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1194085007384	Phosphotransferase enzyme family; Region: APH; pfam01636
1194085007385	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1194085007386	active site
1194085007387	ATP binding site [chemical binding]; other site
1194085007388	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1194085007389	active site
1194085007390	ATP binding site [chemical binding]; other site
1194085007391	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1194085007392	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1194085007393	quinone interaction residues [chemical binding]; other site
1194085007394	active site
1194085007395	catalytic residues [active]
1194085007396	FMN binding site [chemical binding]; other site
1194085007397	substrate binding site [chemical binding]; other site
1194085007398	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1194085007399	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1194085007400	dimer interface [polypeptide binding]; other site
1194085007401	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1194085007402	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1194085007403	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1194085007404	Predicted acyl esterases [General function prediction only]; Region: COG2936
1194085007405	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1194085007406	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1194085007407	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1194085007408	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1194085007409	tetramerization interface [polypeptide binding]; other site
1194085007410	active site
1194085007411	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1194085007412	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1194085007413	active site
1194085007414	ATP-binding site [chemical binding]; other site
1194085007415	pantoate-binding site; other site
1194085007416	HXXH motif; other site
1194085007417	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1194085007418	oligomerization interface [polypeptide binding]; other site
1194085007419	active site
1194085007420	metal binding site [ion binding]; metal-binding site
1194085007421	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1194085007422	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1194085007423	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1194085007424	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1194085007425	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1194085007426	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1194085007427	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1194085007428	NAD binding site [chemical binding]; other site
1194085007429	dimer interface [polypeptide binding]; other site
1194085007430	substrate binding site [chemical binding]; other site
1194085007431	amino acid transporter; Region: 2A0306; TIGR00909
1194085007432	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
1194085007433	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1194085007434	inhibitor-cofactor binding pocket; inhibition site
1194085007435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085007436	catalytic residue [active]
1194085007437	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
1194085007438	catalytic residue [active]
1194085007439	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
1194085007440	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1194085007441	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1194085007442	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1194085007443	acyl-activating enzyme (AAE) consensus motif; other site
1194085007444	AMP binding site [chemical binding]; other site
1194085007445	active site
1194085007446	CoA binding site [chemical binding]; other site
1194085007447	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1194085007448	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1194085007449	choline dehydrogenase; Validated; Region: PRK02106
1194085007450	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1194085007451	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1194085007452	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1194085007453	tetramerization interface [polypeptide binding]; other site
1194085007454	NAD(P) binding site [chemical binding]; other site
1194085007455	catalytic residues [active]
1194085007456	Predicted transcriptional regulators [Transcription]; Region: COG1510
1194085007457	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1194085007458	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1194085007459	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1194085007460	FeS/SAM binding site; other site
1194085007461	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
1194085007462	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1194085007463	effector binding site; other site
1194085007464	active site
1194085007465	Zn binding site [ion binding]; other site
1194085007466	glycine loop; other site
1194085007467	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1194085007468	Citrate transporter; Region: CitMHS; pfam03600
1194085007469	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
1194085007470	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1194085007471	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1194085007472	Flavodoxin; Region: Flavodoxin_1; pfam00258
1194085007473	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1194085007474	FAD binding pocket [chemical binding]; other site
1194085007475	FAD binding motif [chemical binding]; other site
1194085007476	catalytic residues [active]
1194085007477	NAD binding pocket [chemical binding]; other site
1194085007478	phosphate binding motif [ion binding]; other site
1194085007479	beta-alpha-beta structure motif; other site
1194085007480	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1194085007481	catalytic residues [active]
1194085007482	dimer interface [polypeptide binding]; other site
1194085007483	FtsX-like permease family; Region: FtsX; pfam02687
1194085007484	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1194085007485	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1194085007486	Walker A/P-loop; other site
1194085007487	ATP binding site [chemical binding]; other site
1194085007488	Q-loop/lid; other site
1194085007489	ABC transporter signature motif; other site
1194085007490	Walker B; other site
1194085007491	D-loop; other site
1194085007492	H-loop/switch region; other site
1194085007493	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1194085007494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1194085007495	ATP binding site [chemical binding]; other site
1194085007496	Mg2+ binding site [ion binding]; other site
1194085007497	G-X-G motif; other site
1194085007498	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1194085007499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1194085007500	active site
1194085007501	phosphorylation site [posttranslational modification]
1194085007502	intermolecular recognition site; other site
1194085007503	dimerization interface [polypeptide binding]; other site
1194085007504	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1194085007505	DNA binding site [nucleotide binding]
1194085007506	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1194085007507	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1194085007508	dimer interface [polypeptide binding]; other site
1194085007509	active site
1194085007510	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1194085007511	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1194085007512	MarR family; Region: MarR_2; pfam12802
1194085007513	Predicted esterase [General function prediction only]; Region: COG0627
1194085007514	S-formylglutathione hydrolase; Region: PLN02442
1194085007515	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1194085007516	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1194085007517	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1194085007518	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1194085007519	ligand binding site [chemical binding]; other site
1194085007520	flexible hinge region; other site
1194085007521	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1194085007522	carbamate kinase; Reviewed; Region: PRK12686
1194085007523	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1194085007524	putative substrate binding site [chemical binding]; other site
1194085007525	nucleotide binding site [chemical binding]; other site
1194085007526	nucleotide binding site [chemical binding]; other site
1194085007527	homodimer interface [polypeptide binding]; other site
1194085007528	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1194085007529	ornithine carbamoyltransferase; Validated; Region: PRK02102
1194085007530	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1194085007531	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1194085007532	arginine deiminase; Provisional; Region: PRK01388
1194085007533	Arginine repressor [Transcription]; Region: ArgR; COG1438
1194085007534	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1194085007535	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1194085007536	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1194085007537	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1194085007538	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1194085007539	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1194085007540	active site
1194085007541	Zn binding site [ion binding]; other site
1194085007542	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1194085007543	HTH domain; Region: HTH_11; pfam08279
1194085007544	PRD domain; Region: PRD; pfam00874
1194085007545	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1194085007546	active site
1194085007547	P-loop; other site
1194085007548	phosphorylation site [posttranslational modification]
1194085007549	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1194085007550	active site
1194085007551	phosphorylation site [posttranslational modification]
1194085007552	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1194085007553	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1194085007554	active site
1194085007555	P-loop; other site
1194085007556	phosphorylation site [posttranslational modification]
1194085007557	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1194085007558	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1194085007559	active site
1194085007560	phosphorylation site [posttranslational modification]
1194085007561	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1194085007562	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1194085007563	Predicted membrane protein [Function unknown]; Region: COG1511
1194085007564	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1194085007565	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1194085007566	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
1194085007567	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1194085007568	CHAP domain; Region: CHAP; pfam05257
1194085007569	Isochorismatase family; Region: Isochorismatase; pfam00857
1194085007570	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1194085007571	catalytic triad [active]
1194085007572	conserved cis-peptide bond; other site
1194085007573	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1194085007574	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1194085007575	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1194085007576	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1194085007577	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
1194085007578	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1194085007579	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1194085007580	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1194085007581	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1194085007582	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1194085007583	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1194085007584	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
1194085007585	SecY translocase; Region: SecY; pfam00344
1194085007586	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1194085007587	legume lectins; Region: lectin_L-type; cd01951
1194085007588	homotetramer interaction site [polypeptide binding]; other site
1194085007589	carbohydrate binding site [chemical binding]; other site
1194085007590	metal binding site [ion binding]; metal-binding site
1194085007591	Putative Ig domain; Region: He_PIG; pfam05345
1194085007592	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1194085007593	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1194085007594	methionine sulfoxide reductase A; Provisional; Region: PRK05528
1194085007595	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1194085007596	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1194085007597	Coenzyme A binding pocket [chemical binding]; other site
1194085007598	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1194085007599	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1194085007600	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1194085007601	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1194085007602	Chain length determinant protein; Region: Wzz; cl15801
1194085007603	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1194085007604	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1194085007605	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1194085007606	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1194085007607	DXD motif; other site
1194085007608	intracellular adhesion protein D; Region: PIA_icaD; TIGR03932
1194085007609	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
1194085007610	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1194085007611	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1194085007612	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1194085007613	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1194085007614	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1194085007615	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1194085007616	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1194085007617	metal binding site [ion binding]; metal-binding site
1194085007618	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1194085007619	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1194085007620	substrate binding site [chemical binding]; other site
1194085007621	glutamase interaction surface [polypeptide binding]; other site
1194085007622	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1194085007623	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1194085007624	catalytic residues [active]
1194085007625	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
1194085007626	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1194085007627	putative active site [active]
1194085007628	oxyanion strand; other site
1194085007629	catalytic triad [active]
1194085007630	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1194085007631	putative active site pocket [active]
1194085007632	4-fold oligomerization interface [polypeptide binding]; other site
1194085007633	metal binding residues [ion binding]; metal-binding site
1194085007634	3-fold/trimer interface [polypeptide binding]; other site
1194085007635	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1194085007636	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1194085007637	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1194085007638	homodimer interface [polypeptide binding]; other site
1194085007639	catalytic residue [active]
1194085007640	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1194085007641	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1194085007642	NAD binding site [chemical binding]; other site
1194085007643	dimerization interface [polypeptide binding]; other site
1194085007644	product binding site; other site
1194085007645	substrate binding site [chemical binding]; other site
1194085007646	zinc binding site [ion binding]; other site
1194085007647	catalytic residues [active]
1194085007648	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
1194085007649	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1194085007650	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
1194085007651	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
1194085007652	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1194085007653	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1194085007654	putative active site [active]
1194085007655	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1194085007656	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1194085007657	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1194085007658	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1194085007659	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1194085007660	Walker A/P-loop; other site
1194085007661	ATP binding site [chemical binding]; other site
1194085007662	Q-loop/lid; other site
1194085007663	ABC transporter signature motif; other site
1194085007664	Walker B; other site
1194085007665	D-loop; other site
1194085007666	H-loop/switch region; other site
1194085007667	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1194085007668	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1194085007669	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1194085007670	Walker A/P-loop; other site
1194085007671	ATP binding site [chemical binding]; other site
1194085007672	Q-loop/lid; other site
1194085007673	ABC transporter signature motif; other site
1194085007674	Walker B; other site
1194085007675	D-loop; other site
1194085007676	H-loop/switch region; other site
1194085007677	hypothetical protein; Provisional; Region: PRK13661
1194085007678	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1194085007679	Uncharacterized conserved protein [Function unknown]; Region: COG1912
1194085007680	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1194085007681	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1194085007682	Strictosidine synthase; Region: Str_synth; pfam03088
1194085007683	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1194085007684	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1194085007685	active site residue [active]
1194085007686	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1194085007687	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1194085007688	putative substrate binding pocket [chemical binding]; other site
1194085007689	AC domain interface; other site
1194085007690	catalytic triad [active]
1194085007691	AB domain interface; other site
1194085007692	interchain disulfide; other site
1194085007693	hypothetical protein; Validated; Region: PRK07668
1194085007694	Predicted transcriptional regulators [Transcription]; Region: COG1695
1194085007695	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1194085007696	DinB superfamily; Region: DinB_2; pfam12867
1194085007697	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1194085007698	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1194085007699	transmembrane helices; other site
1194085007700	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1194085007701	EamA-like transporter family; Region: EamA; pfam00892
1194085007702	hypothetical protein; Provisional; Region: PRK07758
1194085007703	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1194085007704	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1194085007705	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1194085007706	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1194085007707	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1194085007708	Walker A/P-loop; other site
1194085007709	ATP binding site [chemical binding]; other site
1194085007710	Q-loop/lid; other site
1194085007711	ABC transporter signature motif; other site
1194085007712	Walker B; other site
1194085007713	D-loop; other site
1194085007714	H-loop/switch region; other site
1194085007715	FtsX-like permease family; Region: FtsX; pfam02687
1194085007716	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1194085007717	Integrase core domain; Region: rve; pfam00665
1194085007718	Integrase core domain; Region: rve_3; cl15866
1194085007719	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1194085007720	Integrase core domain; Region: rve; pfam00665
1194085007721	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1194085007722	DNA-binding site [nucleotide binding]; DNA binding site
1194085007723	RNA-binding motif; other site
1194085007724	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1194085007725	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1194085007726	non-specific DNA binding site [nucleotide binding]; other site
1194085007727	salt bridge; other site
1194085007728	sequence-specific DNA binding site [nucleotide binding]; other site
1194085007729	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1194085007730	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1194085007731	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1194085007732	ParB-like nuclease domain; Region: ParBc; pfam02195
1194085007733	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1194085007734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1194085007735	S-adenosylmethionine binding site [chemical binding]; other site
1194085007736	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1194085007737	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1194085007738	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1194085007739	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1194085007740	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1194085007741	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1194085007742	G1 box; other site
1194085007743	GTP/Mg2+ binding site [chemical binding]; other site
1194085007744	Switch I region; other site
1194085007745	G2 box; other site
1194085007746	Switch II region; other site
1194085007747	G3 box; other site
1194085007748	G4 box; other site
1194085007749	G5 box; other site
1194085007750	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1194085007751	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1194085007752	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399