-- dump date 20140620_074818 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1201010000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1201010000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1201010000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010000004 Walker A motif; other site 1201010000005 ATP binding site [chemical binding]; other site 1201010000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1201010000007 Walker B motif; other site 1201010000008 arginine finger; other site 1201010000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1201010000010 DnaA box-binding interface [nucleotide binding]; other site 1201010000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1201010000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1201010000013 putative DNA binding surface [nucleotide binding]; other site 1201010000014 dimer interface [polypeptide binding]; other site 1201010000015 beta-clamp/clamp loader binding surface; other site 1201010000016 beta-clamp/translesion DNA polymerase binding surface; other site 1201010000017 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1201010000018 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1201010000019 recF protein; Region: recf; TIGR00611 1201010000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1201010000021 Walker A/P-loop; other site 1201010000022 ATP binding site [chemical binding]; other site 1201010000023 Q-loop/lid; other site 1201010000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010000025 ABC transporter signature motif; other site 1201010000026 Walker B; other site 1201010000027 D-loop; other site 1201010000028 H-loop/switch region; other site 1201010000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1201010000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010000031 Mg2+ binding site [ion binding]; other site 1201010000032 G-X-G motif; other site 1201010000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1201010000034 anchoring element; other site 1201010000035 dimer interface [polypeptide binding]; other site 1201010000036 ATP binding site [chemical binding]; other site 1201010000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1201010000038 active site 1201010000039 putative metal-binding site [ion binding]; other site 1201010000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1201010000041 DNA gyrase subunit A; Validated; Region: PRK05560 1201010000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1201010000043 CAP-like domain; other site 1201010000044 active site 1201010000045 primary dimer interface [polypeptide binding]; other site 1201010000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1201010000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1201010000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1201010000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1201010000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1201010000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1201010000052 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1201010000053 putative substrate binding site [chemical binding]; other site 1201010000054 putative ATP binding site [chemical binding]; other site 1201010000055 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1201010000056 active sites [active] 1201010000057 tetramer interface [polypeptide binding]; other site 1201010000058 seryl-tRNA synthetase; Provisional; Region: PRK05431 1201010000059 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1201010000060 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1201010000061 dimer interface [polypeptide binding]; other site 1201010000062 active site 1201010000063 motif 1; other site 1201010000064 motif 2; other site 1201010000065 motif 3; other site 1201010000066 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1201010000067 Predicted membrane protein [Function unknown]; Region: COG4392 1201010000068 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1201010000069 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1201010000070 Predicted membrane protein [Function unknown]; Region: COG4241 1201010000071 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1201010000072 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1201010000073 DHH family; Region: DHH; pfam01368 1201010000074 DHHA1 domain; Region: DHHA1; pfam02272 1201010000075 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1201010000076 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1201010000077 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1201010000078 replicative DNA helicase; Region: DnaB; TIGR00665 1201010000079 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1201010000080 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1201010000081 Walker A motif; other site 1201010000082 ATP binding site [chemical binding]; other site 1201010000083 Walker B motif; other site 1201010000084 DNA binding loops [nucleotide binding] 1201010000085 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1201010000086 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1201010000087 GDP-binding site [chemical binding]; other site 1201010000088 ACT binding site; other site 1201010000089 IMP binding site; other site 1201010000090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1201010000091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010000092 active site 1201010000093 phosphorylation site [posttranslational modification] 1201010000094 intermolecular recognition site; other site 1201010000095 dimerization interface [polypeptide binding]; other site 1201010000096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1201010000097 DNA binding site [nucleotide binding] 1201010000098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1201010000099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1201010000100 dimerization interface [polypeptide binding]; other site 1201010000101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1201010000102 putative active site [active] 1201010000103 heme pocket [chemical binding]; other site 1201010000104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1201010000105 dimer interface [polypeptide binding]; other site 1201010000106 phosphorylation site [posttranslational modification] 1201010000107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010000108 ATP binding site [chemical binding]; other site 1201010000109 Mg2+ binding site [ion binding]; other site 1201010000110 G-X-G motif; other site 1201010000111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1201010000112 YycH protein; Region: YycH; pfam07435 1201010000113 YycH protein; Region: YycI; cl02015 1201010000114 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1201010000115 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1201010000116 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1201010000117 putative active site [active] 1201010000118 putative metal binding site [ion binding]; other site 1201010000119 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1201010000120 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1201010000121 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1201010000122 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1201010000123 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 1201010000124 GIY-YIG motif/motif A; other site 1201010000125 putative active site [active] 1201010000126 putative metal binding site [ion binding]; other site 1201010000127 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1201010000128 active site 1201010000129 DNA binding site [nucleotide binding] 1201010000130 catalytic site [active] 1201010000131 Phage associated DNA primase [General function prediction only]; Region: COG3378 1201010000132 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1201010000133 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1201010000134 catalytic residues [active] 1201010000135 catalytic nucleophile [active] 1201010000136 Recombinase; Region: Recombinase; pfam07508 1201010000137 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1201010000138 FlxA-like protein; Region: FlxA; pfam14282 1201010000139 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1201010000140 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1201010000141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1201010000142 Integrase core domain; Region: rve; pfam00665 1201010000143 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1201010000144 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1201010000145 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1201010000146 putative active site [active] 1201010000147 catalytic site [active] 1201010000148 putative metal binding site [ion binding]; other site 1201010000149 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1201010000150 putative active site [active] 1201010000151 putative catalytic site [active] 1201010000152 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1201010000153 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1201010000154 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1201010000155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1201010000156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1201010000157 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1201010000158 dimer interface [polypeptide binding]; other site 1201010000159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1201010000160 Predicted transcriptional regulator [Transcription]; Region: COG2378 1201010000161 HTH domain; Region: HTH_11; pfam08279 1201010000162 WYL domain; Region: WYL; pfam13280 1201010000163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1201010000164 Homeodomain-like domain; Region: HTH_23; cl17451 1201010000165 putative transposase OrfB; Reviewed; Region: PHA02517 1201010000166 HTH-like domain; Region: HTH_21; pfam13276 1201010000167 Integrase core domain; Region: rve; pfam00665 1201010000168 Integrase core domain; Region: rve_3; cl15866 1201010000169 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1201010000170 active site 1201010000171 DNA binding site [nucleotide binding] 1201010000172 catalytic site [active] 1201010000173 Phage associated DNA primase [General function prediction only]; Region: COG3378 1201010000174 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1201010000175 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1201010000176 catalytic residues [active] 1201010000177 catalytic nucleophile [active] 1201010000178 Recombinase; Region: Recombinase; pfam07508 1201010000179 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1201010000180 FlxA-like protein; Region: FlxA; pfam14282 1201010000181 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 1201010000182 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1201010000183 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1201010000184 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1201010000185 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1201010000186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010000187 ATP binding site [chemical binding]; other site 1201010000188 putative Mg++ binding site [ion binding]; other site 1201010000189 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1201010000190 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1201010000191 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1201010000192 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1201010000193 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1201010000194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010000195 S-adenosylmethionine binding site [chemical binding]; other site 1201010000196 AAA ATPase domain; Region: AAA_15; pfam13175 1201010000197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010000198 Walker A/P-loop; other site 1201010000199 ATP binding site [chemical binding]; other site 1201010000200 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1201010000201 putative active site [active] 1201010000202 putative metal-binding site [ion binding]; other site 1201010000203 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1201010000204 Part of AAA domain; Region: AAA_19; pfam13245 1201010000205 Family description; Region: UvrD_C_2; pfam13538 1201010000206 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1201010000207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010000208 catalytic residue [active] 1201010000209 SIR2-like domain; Region: SIR2_2; pfam13289 1201010000210 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1201010000211 Domain of unknown function DUF87; Region: DUF87; pfam01935 1201010000212 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1201010000213 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1201010000214 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1201010000215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1201010000216 putative DNA binding site [nucleotide binding]; other site 1201010000217 putative Zn2+ binding site [ion binding]; other site 1201010000218 AsnC family; Region: AsnC_trans_reg; pfam01037 1201010000219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010000220 Coenzyme A binding pocket [chemical binding]; other site 1201010000221 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1201010000222 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1201010000223 FMN binding site [chemical binding]; other site 1201010000224 active site 1201010000225 catalytic residues [active] 1201010000226 substrate binding site [chemical binding]; other site 1201010000227 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1201010000228 H+ Antiporter protein; Region: 2A0121; TIGR00900 1201010000229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010000230 putative substrate translocation pore; other site 1201010000231 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1201010000232 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1201010000233 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1201010000234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1201010000235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1201010000236 Winged helix-turn helix; Region: HTH_29; pfam13551 1201010000237 Integrase core domain; Region: rve; pfam00665 1201010000238 transposase/IS protein; Provisional; Region: PRK09183 1201010000239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010000240 Walker A motif; other site 1201010000241 ATP binding site [chemical binding]; other site 1201010000242 Walker B motif; other site 1201010000243 arginine finger; other site 1201010000244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1201010000245 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1201010000246 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1201010000247 Part of AAA domain; Region: AAA_19; pfam13245 1201010000248 AAA domain; Region: AAA_12; pfam13087 1201010000249 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1201010000250 active site 1201010000251 catalytic site [active] 1201010000252 putative metal binding site [ion binding]; other site 1201010000253 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010000254 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1201010000255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1201010000256 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1201010000257 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1201010000258 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1201010000259 metal binding site [ion binding]; metal-binding site 1201010000260 dimer interface [polypeptide binding]; other site 1201010000261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010000262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010000263 putative substrate translocation pore; other site 1201010000264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010000265 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1201010000266 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1201010000267 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1201010000268 PhoU domain; Region: PhoU; pfam01895 1201010000269 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1201010000270 EamA-like transporter family; Region: EamA; pfam00892 1201010000271 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1201010000272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1201010000273 DNA-binding site [nucleotide binding]; DNA binding site 1201010000274 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1201010000275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010000276 homodimer interface [polypeptide binding]; other site 1201010000277 catalytic residue [active] 1201010000278 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1201010000279 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1201010000280 L-lactate permease; Region: Lactate_perm; cl00701 1201010000281 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1201010000282 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1201010000283 B domain; Region: B; pfam02216 1201010000284 B domain; Region: B; pfam02216 1201010000285 B domain; Region: B; pfam02216 1201010000286 B domain; Region: B; pfam02216 1201010000287 B domain; Region: B; pfam02216 1201010000288 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1201010000289 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010000290 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1201010000291 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010000292 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1201010000293 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1201010000294 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010000295 ABC-ATPase subunit interface; other site 1201010000296 dimer interface [polypeptide binding]; other site 1201010000297 putative PBP binding regions; other site 1201010000298 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1201010000299 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010000300 ABC-ATPase subunit interface; other site 1201010000301 dimer interface [polypeptide binding]; other site 1201010000302 putative PBP binding regions; other site 1201010000303 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1201010000304 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1201010000305 siderophore binding site; other site 1201010000306 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1201010000307 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1201010000308 dimer interface [polypeptide binding]; other site 1201010000309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010000310 catalytic residue [active] 1201010000311 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1201010000312 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1201010000313 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1201010000314 IucA / IucC family; Region: IucA_IucC; pfam04183 1201010000315 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1201010000316 drug efflux system protein MdtG; Provisional; Region: PRK09874 1201010000317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010000318 putative substrate translocation pore; other site 1201010000319 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1201010000320 IucA / IucC family; Region: IucA_IucC; pfam04183 1201010000321 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1201010000322 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1201010000323 IucA / IucC family; Region: IucA_IucC; pfam04183 1201010000324 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1201010000325 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1201010000326 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1201010000327 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1201010000328 dimer interface [polypeptide binding]; other site 1201010000329 active site 1201010000330 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1201010000331 catalytic residues [active] 1201010000332 substrate binding site [chemical binding]; other site 1201010000333 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1201010000334 ParB-like nuclease domain; Region: ParBc; pfam02195 1201010000335 acetoin reductase; Validated; Region: PRK08643 1201010000336 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1201010000337 NAD binding site [chemical binding]; other site 1201010000338 homotetramer interface [polypeptide binding]; other site 1201010000339 homodimer interface [polypeptide binding]; other site 1201010000340 active site 1201010000341 substrate binding site [chemical binding]; other site 1201010000342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1201010000343 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1201010000344 NAD(P) binding site [chemical binding]; other site 1201010000345 active site 1201010000346 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1201010000347 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1201010000348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1201010000349 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1201010000350 putative ADP-binding pocket [chemical binding]; other site 1201010000351 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1201010000352 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1201010000353 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1201010000354 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1201010000355 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1201010000356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1201010000357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010000358 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1201010000359 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010000360 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1201010000361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1201010000362 DNA-binding site [nucleotide binding]; DNA binding site 1201010000363 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1201010000364 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1201010000365 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010000366 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1201010000367 intersubunit interface [polypeptide binding]; other site 1201010000368 active site 1201010000369 catalytic residue [active] 1201010000370 phosphopentomutase; Provisional; Region: PRK05362 1201010000371 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1201010000372 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1201010000373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010000374 dimer interface [polypeptide binding]; other site 1201010000375 conserved gate region; other site 1201010000376 putative PBP binding loops; other site 1201010000377 ABC-ATPase subunit interface; other site 1201010000378 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1201010000379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010000380 dimer interface [polypeptide binding]; other site 1201010000381 conserved gate region; other site 1201010000382 ABC-ATPase subunit interface; other site 1201010000383 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1201010000384 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1201010000385 Walker A/P-loop; other site 1201010000386 ATP binding site [chemical binding]; other site 1201010000387 Q-loop/lid; other site 1201010000388 ABC transporter signature motif; other site 1201010000389 Walker B; other site 1201010000390 D-loop; other site 1201010000391 H-loop/switch region; other site 1201010000392 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1201010000393 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1201010000394 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1201010000395 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1201010000396 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1201010000397 active site 1201010000398 metal binding site [ion binding]; metal-binding site 1201010000399 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1201010000400 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1201010000401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010000402 non-specific DNA binding site [nucleotide binding]; other site 1201010000403 salt bridge; other site 1201010000404 sequence-specific DNA binding site [nucleotide binding]; other site 1201010000405 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1201010000406 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1201010000407 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1201010000408 putative catalytic cysteine [active] 1201010000409 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1201010000410 putative active site [active] 1201010000411 metal binding site [ion binding]; metal-binding site 1201010000412 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1201010000413 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1201010000414 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1201010000415 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1201010000416 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1201010000417 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1201010000418 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1201010000419 NAD(P) binding site [chemical binding]; other site 1201010000420 homodimer interface [polypeptide binding]; other site 1201010000421 substrate binding site [chemical binding]; other site 1201010000422 active site 1201010000423 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1201010000424 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1201010000425 NAD(P) binding site [chemical binding]; other site 1201010000426 homodimer interface [polypeptide binding]; other site 1201010000427 substrate binding site [chemical binding]; other site 1201010000428 active site 1201010000429 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1201010000430 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1201010000431 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1201010000432 putative NAD(P) binding site [chemical binding]; other site 1201010000433 active site 1201010000434 putative substrate binding site [chemical binding]; other site 1201010000435 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1201010000436 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1201010000437 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1201010000438 active site 1201010000439 homodimer interface [polypeptide binding]; other site 1201010000440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1201010000441 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1201010000442 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1201010000443 trimer interface [polypeptide binding]; other site 1201010000444 active site 1201010000445 substrate binding site [chemical binding]; other site 1201010000446 CoA binding site [chemical binding]; other site 1201010000447 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1201010000448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1201010000449 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1201010000450 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1201010000451 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1201010000452 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1201010000453 putative NAD(P) binding site [chemical binding]; other site 1201010000454 active site 1201010000455 putative substrate binding site [chemical binding]; other site 1201010000456 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1201010000457 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1201010000458 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1201010000459 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1201010000460 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1201010000461 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1201010000462 active site 1201010000463 homodimer interface [polypeptide binding]; other site 1201010000464 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1201010000465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1201010000466 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1201010000467 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1201010000468 NAD(P) binding site [chemical binding]; other site 1201010000469 catalytic residues [active] 1201010000470 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1201010000471 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1201010000472 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1201010000473 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1201010000474 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1201010000475 Walker A/P-loop; other site 1201010000476 ATP binding site [chemical binding]; other site 1201010000477 Q-loop/lid; other site 1201010000478 ABC transporter signature motif; other site 1201010000479 Walker B; other site 1201010000480 D-loop; other site 1201010000481 H-loop/switch region; other site 1201010000482 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1201010000483 NMT1-like family; Region: NMT1_2; pfam13379 1201010000484 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1201010000485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1201010000486 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1201010000487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1201010000488 active site 1201010000489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010000490 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1201010000491 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1201010000492 acyl-activating enzyme (AAE) consensus motif; other site 1201010000493 AMP binding site [chemical binding]; other site 1201010000494 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1201010000495 Condensation domain; Region: Condensation; pfam00668 1201010000496 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1201010000497 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1201010000498 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1201010000499 acyl-activating enzyme (AAE) consensus motif; other site 1201010000500 AMP binding site [chemical binding]; other site 1201010000501 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1201010000502 thioester reductase domain; Region: Thioester-redct; TIGR01746 1201010000503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1201010000504 NAD(P) binding site [chemical binding]; other site 1201010000505 active site 1201010000506 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1201010000507 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1201010000508 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1201010000509 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1201010000510 nucleotide binding site [chemical binding]; other site 1201010000511 N-acetyl-L-glutamate binding site [chemical binding]; other site 1201010000512 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1201010000513 heterotetramer interface [polypeptide binding]; other site 1201010000514 active site pocket [active] 1201010000515 cleavage site 1201010000516 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1201010000517 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1201010000518 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1201010000519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1201010000520 inhibitor-cofactor binding pocket; inhibition site 1201010000521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010000522 catalytic residue [active] 1201010000523 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1201010000524 Isochorismatase family; Region: Isochorismatase; pfam00857 1201010000525 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1201010000526 catalytic triad [active] 1201010000527 conserved cis-peptide bond; other site 1201010000528 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1201010000529 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1201010000530 dimer interface [polypeptide binding]; other site 1201010000531 PYR/PP interface [polypeptide binding]; other site 1201010000532 TPP binding site [chemical binding]; other site 1201010000533 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1201010000534 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1201010000535 TPP-binding site [chemical binding]; other site 1201010000536 dimer interface [polypeptide binding]; other site 1201010000537 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1201010000538 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1201010000539 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1201010000540 active site turn [active] 1201010000541 phosphorylation site [posttranslational modification] 1201010000542 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1201010000543 HPr interaction site; other site 1201010000544 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1201010000545 active site 1201010000546 phosphorylation site [posttranslational modification] 1201010000547 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1201010000548 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1201010000549 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 1201010000550 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1201010000551 putative active site [active] 1201010000552 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1201010000553 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1201010000554 active site turn [active] 1201010000555 phosphorylation site [posttranslational modification] 1201010000556 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1201010000557 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1201010000558 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1201010000559 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1201010000560 putative active site [active] 1201010000561 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1201010000562 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1201010000563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010000564 ATP binding site [chemical binding]; other site 1201010000565 putative Mg++ binding site [ion binding]; other site 1201010000566 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1201010000567 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010000568 Walker A/P-loop; other site 1201010000569 ATP binding site [chemical binding]; other site 1201010000570 Q-loop/lid; other site 1201010000571 ABC transporter signature motif; other site 1201010000572 Walker B; other site 1201010000573 D-loop; other site 1201010000574 H-loop/switch region; other site 1201010000575 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1201010000576 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010000577 Walker A/P-loop; other site 1201010000578 ATP binding site [chemical binding]; other site 1201010000579 Q-loop/lid; other site 1201010000580 ABC transporter signature motif; other site 1201010000581 Walker B; other site 1201010000582 D-loop; other site 1201010000583 H-loop/switch region; other site 1201010000584 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1201010000585 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1201010000586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010000587 dimer interface [polypeptide binding]; other site 1201010000588 conserved gate region; other site 1201010000589 putative PBP binding loops; other site 1201010000590 ABC-ATPase subunit interface; other site 1201010000591 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1201010000592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010000593 dimer interface [polypeptide binding]; other site 1201010000594 conserved gate region; other site 1201010000595 ABC-ATPase subunit interface; other site 1201010000596 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1201010000597 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1201010000598 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1201010000599 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1201010000600 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1201010000601 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 1201010000602 azoreductase; Reviewed; Region: PRK00170 1201010000603 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1201010000604 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1201010000605 Peptidase family M23; Region: Peptidase_M23; pfam01551 1201010000606 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1201010000607 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1201010000608 Walker A/P-loop; other site 1201010000609 ATP binding site [chemical binding]; other site 1201010000610 Q-loop/lid; other site 1201010000611 ABC transporter signature motif; other site 1201010000612 Walker B; other site 1201010000613 D-loop; other site 1201010000614 H-loop/switch region; other site 1201010000615 TOBE domain; Region: TOBE; pfam03459 1201010000616 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1201010000617 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1201010000618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010000619 dimer interface [polypeptide binding]; other site 1201010000620 conserved gate region; other site 1201010000621 ABC-ATPase subunit interface; other site 1201010000622 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1201010000623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010000624 dimer interface [polypeptide binding]; other site 1201010000625 conserved gate region; other site 1201010000626 putative PBP binding loops; other site 1201010000627 ABC-ATPase subunit interface; other site 1201010000628 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1201010000629 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1201010000630 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1201010000631 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1201010000632 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1201010000633 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1201010000634 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1201010000635 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1201010000636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1201010000637 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1201010000638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010000639 putative substrate translocation pore; other site 1201010000640 Response regulator receiver domain; Region: Response_reg; pfam00072 1201010000641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010000642 active site 1201010000643 phosphorylation site [posttranslational modification] 1201010000644 intermolecular recognition site; other site 1201010000645 dimerization interface [polypeptide binding]; other site 1201010000646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1201010000647 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1201010000648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1201010000649 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1201010000650 Histidine kinase; Region: His_kinase; pfam06580 1201010000651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010000652 ATP binding site [chemical binding]; other site 1201010000653 Mg2+ binding site [ion binding]; other site 1201010000654 G-X-G motif; other site 1201010000655 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1201010000656 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1201010000657 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1201010000658 Pyruvate formate lyase 1; Region: PFL1; cd01678 1201010000659 coenzyme A binding site [chemical binding]; other site 1201010000660 active site 1201010000661 catalytic residues [active] 1201010000662 glycine loop; other site 1201010000663 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1201010000664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010000665 FeS/SAM binding site; other site 1201010000666 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1201010000667 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1201010000668 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1201010000669 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1201010000670 putative active site [active] 1201010000671 catalytic site [active] 1201010000672 putative metal binding site [ion binding]; other site 1201010000673 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1201010000674 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1201010000675 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1201010000676 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1201010000677 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1201010000678 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1201010000679 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1201010000680 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1201010000681 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1201010000682 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1201010000683 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1201010000684 dimer interface [polypeptide binding]; other site 1201010000685 active site 1201010000686 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1201010000687 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1201010000688 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1201010000689 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1201010000690 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1201010000691 substrate binding site [chemical binding]; other site 1201010000692 oxyanion hole (OAH) forming residues; other site 1201010000693 trimer interface [polypeptide binding]; other site 1201010000694 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1201010000695 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1201010000696 active site 1201010000697 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1201010000698 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1201010000699 acyl-activating enzyme (AAE) consensus motif; other site 1201010000700 AMP binding site [chemical binding]; other site 1201010000701 active site 1201010000702 CoA binding site [chemical binding]; other site 1201010000703 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1201010000704 Coenzyme A transferase; Region: CoA_trans; smart00882 1201010000705 Coenzyme A transferase; Region: CoA_trans; cl17247 1201010000706 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1201010000707 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1201010000708 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1201010000709 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1201010000710 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1201010000711 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1201010000712 heme-binding site [chemical binding]; other site 1201010000713 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1201010000714 FAD binding pocket [chemical binding]; other site 1201010000715 FAD binding motif [chemical binding]; other site 1201010000716 phosphate binding motif [ion binding]; other site 1201010000717 beta-alpha-beta structure motif; other site 1201010000718 NAD binding pocket [chemical binding]; other site 1201010000719 Heme binding pocket [chemical binding]; other site 1201010000720 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1201010000721 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1201010000722 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1201010000723 NAD binding site [chemical binding]; other site 1201010000724 dimer interface [polypeptide binding]; other site 1201010000725 substrate binding site [chemical binding]; other site 1201010000726 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1201010000727 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1201010000728 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1201010000729 active site turn [active] 1201010000730 phosphorylation site [posttranslational modification] 1201010000731 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1201010000732 active site 1201010000733 tetramer interface [polypeptide binding]; other site 1201010000734 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1201010000735 Mga helix-turn-helix domain; Region: Mga; pfam05043 1201010000736 PRD domain; Region: PRD; pfam00874 1201010000737 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1201010000738 active site 1201010000739 P-loop; other site 1201010000740 phosphorylation site [posttranslational modification] 1201010000741 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1201010000742 active site 1201010000743 phosphorylation site [posttranslational modification] 1201010000744 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1201010000745 active site 1201010000746 phosphorylation site [posttranslational modification] 1201010000747 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1201010000748 active site 1201010000749 P-loop; other site 1201010000750 phosphorylation site [posttranslational modification] 1201010000751 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1201010000752 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1201010000753 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1201010000754 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1201010000755 putative NAD(P) binding site [chemical binding]; other site 1201010000756 catalytic Zn binding site [ion binding]; other site 1201010000757 structural Zn binding site [ion binding]; other site 1201010000758 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1201010000759 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1201010000760 putative NAD(P) binding site [chemical binding]; other site 1201010000761 catalytic Zn binding site [ion binding]; other site 1201010000762 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1201010000763 substrate binding site; other site 1201010000764 dimer interface; other site 1201010000765 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1201010000766 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1201010000767 NAD(P) binding site [chemical binding]; other site 1201010000768 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1201010000769 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1201010000770 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1201010000771 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1201010000772 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1201010000773 substrate binding site; other site 1201010000774 dimer interface; other site 1201010000775 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1201010000776 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1201010000777 putative NAD(P) binding site [chemical binding]; other site 1201010000778 putative catalytic Zn binding site [ion binding]; other site 1201010000779 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1201010000780 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1201010000781 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1201010000782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1201010000783 active site 1201010000784 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1201010000785 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1201010000786 Hemerythrin-like domain; Region: Hr-like; cd12108 1201010000787 Fe binding site [ion binding]; other site 1201010000788 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1201010000789 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1201010000790 Histidine kinase; Region: His_kinase; pfam06580 1201010000791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010000792 Mg2+ binding site [ion binding]; other site 1201010000793 G-X-G motif; other site 1201010000794 two-component response regulator; Provisional; Region: PRK14084 1201010000795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010000796 active site 1201010000797 phosphorylation site [posttranslational modification] 1201010000798 intermolecular recognition site; other site 1201010000799 dimerization interface [polypeptide binding]; other site 1201010000800 LytTr DNA-binding domain; Region: LytTR; pfam04397 1201010000801 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1201010000802 antiholin-like protein LrgB; Provisional; Region: PRK04288 1201010000803 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1201010000804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1201010000805 DNA-binding site [nucleotide binding]; DNA binding site 1201010000806 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1201010000807 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1201010000808 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1201010000809 HPr interaction site; other site 1201010000810 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1201010000811 active site 1201010000812 phosphorylation site [posttranslational modification] 1201010000813 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1201010000814 beta-galactosidase; Region: BGL; TIGR03356 1201010000815 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1201010000816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010000817 S-adenosylmethionine binding site [chemical binding]; other site 1201010000818 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1201010000819 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1201010000820 substrate binding site [chemical binding]; other site 1201010000821 dimer interface [polypeptide binding]; other site 1201010000822 ATP binding site [chemical binding]; other site 1201010000823 D-ribose pyranase; Provisional; Region: PRK11797 1201010000824 Sugar transport protein; Region: Sugar_transport; pfam06800 1201010000825 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1201010000826 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1201010000827 DNA binding site [nucleotide binding] 1201010000828 domain linker motif; other site 1201010000829 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1201010000830 dimerization interface [polypeptide binding]; other site 1201010000831 ligand binding site [chemical binding]; other site 1201010000832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010000833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010000834 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1201010000835 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1201010000836 active site 1201010000837 Surface antigen [General function prediction only]; Region: COG3942 1201010000838 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1201010000839 Peptidase family M23; Region: Peptidase_M23; pfam01551 1201010000840 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1201010000841 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1201010000842 Walker A/P-loop; other site 1201010000843 ATP binding site [chemical binding]; other site 1201010000844 Q-loop/lid; other site 1201010000845 ABC transporter signature motif; other site 1201010000846 Walker B; other site 1201010000847 D-loop; other site 1201010000848 H-loop/switch region; other site 1201010000849 Surface antigen [General function prediction only]; Region: COG3942 1201010000850 CHAP domain; Region: CHAP; pfam05257 1201010000851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1201010000852 Predicted membrane protein [Function unknown]; Region: COG1511 1201010000853 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1201010000854 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1201010000855 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1201010000856 Uncharacterized small protein [Function unknown]; Region: COG5417 1201010000857 Predicted membrane protein [Function unknown]; Region: COG4499 1201010000858 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1201010000859 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1201010000860 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1201010000861 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1201010000862 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1201010000863 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 1201010000864 LXG domain of WXG superfamily; Region: LXG; pfam04740 1201010000865 Protein of unknown function, DUF600; Region: DUF600; cl04640 1201010000866 Protein of unknown function, DUF600; Region: DUF600; cl04640 1201010000867 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 1201010000868 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1201010000869 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1201010000870 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1201010000871 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 1201010000872 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1201010000873 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1201010000874 FtsX-like permease family; Region: FtsX; pfam02687 1201010000875 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1201010000876 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1201010000877 Walker A/P-loop; other site 1201010000878 ATP binding site [chemical binding]; other site 1201010000879 Q-loop/lid; other site 1201010000880 ABC transporter signature motif; other site 1201010000881 Walker B; other site 1201010000882 D-loop; other site 1201010000883 H-loop/switch region; other site 1201010000884 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1201010000885 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1201010000886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010000887 non-specific DNA binding site [nucleotide binding]; other site 1201010000888 salt bridge; other site 1201010000889 sequence-specific DNA binding site [nucleotide binding]; other site 1201010000890 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1201010000891 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1201010000892 substrate binding site [chemical binding]; other site 1201010000893 ATP binding site [chemical binding]; other site 1201010000894 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1201010000895 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1201010000896 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1201010000897 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1201010000898 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1201010000899 putative transporter; Provisional; Region: PRK10484 1201010000900 Na binding site [ion binding]; other site 1201010000901 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1201010000902 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1201010000903 inhibitor site; inhibition site 1201010000904 active site 1201010000905 dimer interface [polypeptide binding]; other site 1201010000906 catalytic residue [active] 1201010000907 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1201010000908 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1201010000909 nucleotide binding site [chemical binding]; other site 1201010000910 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1201010000911 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1201010000912 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1201010000913 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1201010000914 putative active site [active] 1201010000915 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1201010000916 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1201010000917 putative active site cavity [active] 1201010000918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1201010000919 Nucleoside recognition; Region: Gate; pfam07670 1201010000920 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1201010000921 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1201010000922 PGAP1-like protein; Region: PGAP1; pfam07819 1201010000923 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1201010000924 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1201010000925 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1201010000926 putative active site [active] 1201010000927 putative FMN binding site [chemical binding]; other site 1201010000928 putative substrate binding site [chemical binding]; other site 1201010000929 putative catalytic residue [active] 1201010000930 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1201010000931 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1201010000932 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1201010000933 lipoyl attachment site [posttranslational modification]; other site 1201010000934 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1201010000935 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1201010000936 putative ADP-ribose binding site [chemical binding]; other site 1201010000937 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1201010000938 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1201010000939 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1201010000940 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1201010000941 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1201010000942 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1201010000943 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1201010000944 active site 1201010000945 P-loop; other site 1201010000946 phosphorylation site [posttranslational modification] 1201010000947 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1201010000948 active site 1201010000949 phosphorylation site [posttranslational modification] 1201010000950 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1201010000951 HTH domain; Region: HTH_11; pfam08279 1201010000952 HTH domain; Region: HTH_11; pfam08279 1201010000953 PRD domain; Region: PRD; pfam00874 1201010000954 PRD domain; Region: PRD; pfam00874 1201010000955 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1201010000956 active site 1201010000957 P-loop; other site 1201010000958 phosphorylation site [posttranslational modification] 1201010000959 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1201010000960 active site 1201010000961 phosphorylation site [posttranslational modification] 1201010000962 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1201010000963 MarR family; Region: MarR_2; pfam12802 1201010000964 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1201010000965 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1201010000966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 1201010000967 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1201010000968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010000969 putative substrate translocation pore; other site 1201010000970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010000971 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1201010000972 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1201010000973 Zn binding site [ion binding]; other site 1201010000974 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1201010000975 Zn binding site [ion binding]; other site 1201010000976 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1201010000977 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1201010000978 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1201010000979 Predicted flavoprotein [General function prediction only]; Region: COG0431 1201010000980 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1201010000981 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1201010000982 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1201010000983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1201010000984 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1201010000985 Imelysin; Region: Peptidase_M75; pfam09375 1201010000986 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1201010000987 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1201010000988 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1201010000989 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1201010000990 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1201010000991 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1201010000992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010000993 non-specific DNA binding site [nucleotide binding]; other site 1201010000994 salt bridge; other site 1201010000995 sequence-specific DNA binding site [nucleotide binding]; other site 1201010000996 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1201010000997 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1201010000998 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1201010000999 Walker A/P-loop; other site 1201010001000 ATP binding site [chemical binding]; other site 1201010001001 Q-loop/lid; other site 1201010001002 ABC transporter signature motif; other site 1201010001003 Walker B; other site 1201010001004 D-loop; other site 1201010001005 H-loop/switch region; other site 1201010001006 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1201010001007 Predicted membrane protein [Function unknown]; Region: COG4292 1201010001008 putative acyltransferase; Provisional; Region: PRK05790 1201010001009 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1201010001010 dimer interface [polypeptide binding]; other site 1201010001011 active site 1201010001012 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1201010001013 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1201010001014 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1201010001015 THF binding site; other site 1201010001016 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1201010001017 substrate binding site [chemical binding]; other site 1201010001018 THF binding site; other site 1201010001019 zinc-binding site [ion binding]; other site 1201010001020 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1201010001021 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1201010001022 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1201010001023 FAD binding site [chemical binding]; other site 1201010001024 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1201010001025 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1201010001026 homodimer interface [polypeptide binding]; other site 1201010001027 substrate-cofactor binding pocket; other site 1201010001028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010001029 catalytic residue [active] 1201010001030 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1201010001031 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1201010001032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1201010001033 catalytic residue [active] 1201010001034 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1201010001035 ParB-like nuclease domain; Region: ParB; smart00470 1201010001036 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1201010001037 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1201010001038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 1201010001039 GTP-binding protein YchF; Reviewed; Region: PRK09601 1201010001040 YchF GTPase; Region: YchF; cd01900 1201010001041 G1 box; other site 1201010001042 GTP/Mg2+ binding site [chemical binding]; other site 1201010001043 Switch I region; other site 1201010001044 G2 box; other site 1201010001045 Switch II region; other site 1201010001046 G3 box; other site 1201010001047 G4 box; other site 1201010001048 G5 box; other site 1201010001049 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1201010001050 Winged helix-turn helix; Region: HTH_29; pfam13551 1201010001051 Integrase core domain; Region: rve; pfam00665 1201010001052 transposase/IS protein; Provisional; Region: PRK09183 1201010001053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010001054 Walker A motif; other site 1201010001055 ATP binding site [chemical binding]; other site 1201010001056 Walker B motif; other site 1201010001057 arginine finger; other site 1201010001058 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1201010001059 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1201010001060 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1201010001061 dimer interface [polypeptide binding]; other site 1201010001062 ssDNA binding site [nucleotide binding]; other site 1201010001063 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1201010001064 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1201010001065 Abi-like protein; Region: Abi_2; pfam07751 1201010001066 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1201010001068 Predicted membrane protein [Function unknown]; Region: COG3212 1201010001069 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1201010001070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1201010001071 non-specific DNA binding site [nucleotide binding]; other site 1201010001072 salt bridge; other site 1201010001073 sequence-specific DNA binding site [nucleotide binding]; other site 1201010001074 Predicted membrane protein [Function unknown]; Region: COG2261 1201010001075 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1201010001076 catalytic core [active] 1201010001077 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1201010001078 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1201010001079 catalytic residue [active] 1201010001080 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1201010001081 catalytic residues [active] 1201010001082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1201010001083 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010001084 peroxiredoxin; Region: AhpC; TIGR03137 1201010001085 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1201010001086 dimer interface [polypeptide binding]; other site 1201010001087 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1201010001088 catalytic triad [active] 1201010001089 peroxidatic and resolving cysteines [active] 1201010001090 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1201010001091 dimer interface [polypeptide binding]; other site 1201010001092 FMN binding site [chemical binding]; other site 1201010001093 NADPH bind site [chemical binding]; other site 1201010001094 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1201010001095 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1201010001096 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1201010001097 active site 1201010001098 xanthine permease; Region: pbuX; TIGR03173 1201010001099 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1201010001100 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1201010001101 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1201010001102 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1201010001103 active site 1201010001104 GMP synthase; Reviewed; Region: guaA; PRK00074 1201010001105 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1201010001106 AMP/PPi binding site [chemical binding]; other site 1201010001107 candidate oxyanion hole; other site 1201010001108 catalytic triad [active] 1201010001109 potential glutamine specificity residues [chemical binding]; other site 1201010001110 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1201010001111 ATP Binding subdomain [chemical binding]; other site 1201010001112 Ligand Binding sites [chemical binding]; other site 1201010001113 Dimerization subdomain; other site 1201010001114 Abi-like protein; Region: Abi_2; pfam07751 1201010001115 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1201010001116 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1201010001117 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1201010001118 Divergent AAA domain; Region: AAA_4; pfam04326 1201010001119 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1201010001120 Predicted membrane protein [Function unknown]; Region: COG3759 1201010001121 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1201010001122 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1201010001123 NADP binding site [chemical binding]; other site 1201010001124 superantigen-like protein; Reviewed; Region: PRK13037 1201010001125 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001126 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001127 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1201010001128 superantigen-like protein; Reviewed; Region: PRK13041 1201010001129 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001130 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001131 superantigen-like protein; Reviewed; Region: PRK13335 1201010001132 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001133 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001134 superantigen-like protein; Reviewed; Region: PRK13040 1201010001135 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001136 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001137 superantigen-like protein 5; Reviewed; Region: PRK13035 1201010001138 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001139 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001140 superantigen-like protein 7; Reviewed; Region: PRK13346 1201010001141 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001142 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001143 superantigen-like protein; Reviewed; Region: PRK13039 1201010001144 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001145 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001146 superantigen-like protein; Reviewed; Region: PRK13345 1201010001147 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001148 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001149 superantigen-like protein; Reviewed; Region: PRK13038 1201010001150 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001151 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001152 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1201010001153 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1201010001154 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1201010001155 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1201010001156 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1201010001157 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1201010001158 superantigen-like protein; Reviewed; Region: PRK13036 1201010001159 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1201010001160 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010001161 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010001162 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010001163 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010001164 Protein of unknown function, DUF576; Region: DUF576; cl04553 1201010001165 transposase/IS protein; Provisional; Region: PRK09183 1201010001166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010001167 Walker A motif; other site 1201010001168 ATP binding site [chemical binding]; other site 1201010001169 Walker B motif; other site 1201010001170 arginine finger; other site 1201010001171 Winged helix-turn helix; Region: HTH_29; pfam13551 1201010001172 Integrase core domain; Region: rve; pfam00665 1201010001173 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010001174 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010001175 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010001176 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010001177 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1201010001178 nucleophilic elbow; other site 1201010001179 catalytic triad; other site 1201010001180 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1201010001181 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1201010001182 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1201010001183 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1201010001184 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1201010001185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1201010001186 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1201010001187 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1201010001188 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1201010001189 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1201010001190 active site 1201010001191 Esterase/lipase [General function prediction only]; Region: COG1647 1201010001192 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1201010001193 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1201010001194 Na2 binding site [ion binding]; other site 1201010001195 putative substrate binding site 1 [chemical binding]; other site 1201010001196 Na binding site 1 [ion binding]; other site 1201010001197 putative substrate binding site 2 [chemical binding]; other site 1201010001198 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1201010001199 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1201010001200 dimer interface [polypeptide binding]; other site 1201010001201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010001202 catalytic residue [active] 1201010001203 cystathionine beta-lyase; Provisional; Region: PRK07671 1201010001204 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1201010001205 homodimer interface [polypeptide binding]; other site 1201010001206 substrate-cofactor binding pocket; other site 1201010001207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010001208 catalytic residue [active] 1201010001209 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1201010001210 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1201010001211 Walker A/P-loop; other site 1201010001212 ATP binding site [chemical binding]; other site 1201010001213 Q-loop/lid; other site 1201010001214 ABC transporter signature motif; other site 1201010001215 Walker B; other site 1201010001216 D-loop; other site 1201010001217 H-loop/switch region; other site 1201010001218 NIL domain; Region: NIL; pfam09383 1201010001219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010001220 dimer interface [polypeptide binding]; other site 1201010001221 conserved gate region; other site 1201010001222 ABC-ATPase subunit interface; other site 1201010001223 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1201010001224 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1201010001225 LysM domain; Region: LysM; pfam01476 1201010001226 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1201010001227 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1201010001228 Surface antigen [General function prediction only]; Region: COG3942 1201010001229 CHAP domain; Region: CHAP; pfam05257 1201010001230 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1201010001231 nudix motif; other site 1201010001232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010001233 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1201010001234 Coenzyme A binding pocket [chemical binding]; other site 1201010001235 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1201010001236 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1201010001237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1201010001238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1201010001239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1201010001240 dimerization interface [polypeptide binding]; other site 1201010001241 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1201010001242 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1201010001243 active site 1201010001244 dimer interface [polypeptide binding]; other site 1201010001245 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1201010001246 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1201010001247 active site 1201010001248 FMN binding site [chemical binding]; other site 1201010001249 substrate binding site [chemical binding]; other site 1201010001250 3Fe-4S cluster binding site [ion binding]; other site 1201010001251 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1201010001252 domain interface; other site 1201010001253 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1201010001254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1201010001255 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1201010001256 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1201010001257 active site turn [active] 1201010001258 phosphorylation site [posttranslational modification] 1201010001259 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1201010001260 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1201010001261 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1201010001262 Ca binding site [ion binding]; other site 1201010001263 active site 1201010001264 catalytic site [active] 1201010001265 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1201010001266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1201010001267 DNA-binding site [nucleotide binding]; DNA binding site 1201010001268 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1201010001269 UTRA domain; Region: UTRA; pfam07702 1201010001270 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1201010001271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010001272 Coenzyme A binding pocket [chemical binding]; other site 1201010001273 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1201010001274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010001275 Walker A motif; other site 1201010001276 ATP binding site [chemical binding]; other site 1201010001277 Walker B motif; other site 1201010001278 arginine finger; other site 1201010001279 hypothetical protein; Validated; Region: PRK00153 1201010001280 recombination protein RecR; Reviewed; Region: recR; PRK00076 1201010001281 RecR protein; Region: RecR; pfam02132 1201010001282 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1201010001283 putative active site [active] 1201010001284 putative metal-binding site [ion binding]; other site 1201010001285 tetramer interface [polypeptide binding]; other site 1201010001286 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1201010001287 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1201010001288 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1201010001289 catalytic residue [active] 1201010001290 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1201010001291 thymidylate kinase; Validated; Region: tmk; PRK00698 1201010001292 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1201010001293 TMP-binding site; other site 1201010001294 ATP-binding site [chemical binding]; other site 1201010001295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1201010001296 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1201010001297 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1201010001298 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1201010001299 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1201010001300 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1201010001301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010001302 S-adenosylmethionine binding site [chemical binding]; other site 1201010001303 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1201010001304 GIY-YIG motif/motif A; other site 1201010001305 putative active site [active] 1201010001306 putative metal binding site [ion binding]; other site 1201010001307 Predicted methyltransferases [General function prediction only]; Region: COG0313 1201010001308 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1201010001309 putative SAM binding site [chemical binding]; other site 1201010001310 putative homodimer interface [polypeptide binding]; other site 1201010001311 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1201010001312 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1201010001313 active site 1201010001314 HIGH motif; other site 1201010001315 KMSKS motif; other site 1201010001316 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1201010001317 tRNA binding surface [nucleotide binding]; other site 1201010001318 anticodon binding site; other site 1201010001319 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1201010001320 dimer interface [polypeptide binding]; other site 1201010001321 putative tRNA-binding site [nucleotide binding]; other site 1201010001322 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1201010001323 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1201010001324 active site 1201010001325 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1201010001326 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1201010001327 putative active site [active] 1201010001328 putative metal binding site [ion binding]; other site 1201010001329 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1201010001330 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1201010001331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010001332 S-adenosylmethionine binding site [chemical binding]; other site 1201010001333 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1201010001334 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1201010001335 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1201010001336 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1201010001337 pur operon repressor; Provisional; Region: PRK09213 1201010001338 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1201010001339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1201010001340 active site 1201010001341 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1201010001342 homotrimer interaction site [polypeptide binding]; other site 1201010001343 putative active site [active] 1201010001344 regulatory protein SpoVG; Reviewed; Region: PRK13259 1201010001345 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1201010001346 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1201010001347 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1201010001348 Substrate binding site; other site 1201010001349 Mg++ binding site; other site 1201010001350 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1201010001351 active site 1201010001352 substrate binding site [chemical binding]; other site 1201010001353 CoA binding site [chemical binding]; other site 1201010001354 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1201010001355 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1201010001356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1201010001357 active site 1201010001358 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1201010001359 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1201010001360 5S rRNA interface [nucleotide binding]; other site 1201010001361 CTC domain interface [polypeptide binding]; other site 1201010001362 L16 interface [polypeptide binding]; other site 1201010001363 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1201010001364 putative active site [active] 1201010001365 catalytic residue [active] 1201010001366 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1201010001367 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1201010001368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010001369 ATP binding site [chemical binding]; other site 1201010001370 putative Mg++ binding site [ion binding]; other site 1201010001371 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1201010001372 nucleotide binding region [chemical binding]; other site 1201010001373 ATP-binding site [chemical binding]; other site 1201010001374 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1201010001375 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1201010001376 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1201010001377 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1201010001378 putative SAM binding site [chemical binding]; other site 1201010001379 putative homodimer interface [polypeptide binding]; other site 1201010001380 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1201010001381 homodimer interface [polypeptide binding]; other site 1201010001382 metal binding site [ion binding]; metal-binding site 1201010001383 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1201010001384 RNA binding surface [nucleotide binding]; other site 1201010001385 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1201010001386 Septum formation initiator; Region: DivIC; pfam04977 1201010001387 hypothetical protein; Provisional; Region: PRK08582 1201010001388 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1201010001389 RNA binding site [nucleotide binding]; other site 1201010001390 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1201010001391 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1201010001392 Ligand Binding Site [chemical binding]; other site 1201010001393 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1201010001394 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1201010001395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1201010001396 active site 1201010001397 FtsH Extracellular; Region: FtsH_ext; pfam06480 1201010001398 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1201010001399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010001400 Walker A motif; other site 1201010001401 ATP binding site [chemical binding]; other site 1201010001402 Walker B motif; other site 1201010001403 arginine finger; other site 1201010001404 Peptidase family M41; Region: Peptidase_M41; pfam01434 1201010001405 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1201010001406 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1201010001407 dimerization interface [polypeptide binding]; other site 1201010001408 domain crossover interface; other site 1201010001409 redox-dependent activation switch; other site 1201010001410 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1201010001411 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1201010001412 dimer interface [polypeptide binding]; other site 1201010001413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010001414 catalytic residue [active] 1201010001415 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1201010001416 dihydropteroate synthase; Region: DHPS; TIGR01496 1201010001417 substrate binding pocket [chemical binding]; other site 1201010001418 dimer interface [polypeptide binding]; other site 1201010001419 inhibitor binding site; inhibition site 1201010001420 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1201010001421 homooctamer interface [polypeptide binding]; other site 1201010001422 active site 1201010001423 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1201010001424 catalytic center binding site [active] 1201010001425 ATP binding site [chemical binding]; other site 1201010001426 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1201010001427 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1201010001428 dimer interface [polypeptide binding]; other site 1201010001429 putative anticodon binding site; other site 1201010001430 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1201010001431 motif 1; other site 1201010001432 active site 1201010001433 motif 2; other site 1201010001434 motif 3; other site 1201010001435 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1201010001436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1201010001437 DNA-binding site [nucleotide binding]; DNA binding site 1201010001438 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1201010001439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010001440 homodimer interface [polypeptide binding]; other site 1201010001441 catalytic residue [active] 1201010001442 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1201010001443 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1201010001444 active site 1201010001445 multimer interface [polypeptide binding]; other site 1201010001446 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1201010001447 predicted active site [active] 1201010001448 catalytic triad [active] 1201010001449 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1201010001450 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1201010001451 Nucleoside recognition; Region: Gate; pfam07670 1201010001452 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1201010001453 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1201010001454 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1201010001455 UvrB/uvrC motif; Region: UVR; pfam02151 1201010001456 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1201010001457 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1201010001458 ADP binding site [chemical binding]; other site 1201010001459 phosphagen binding site; other site 1201010001460 substrate specificity loop; other site 1201010001461 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1201010001462 Clp amino terminal domain; Region: Clp_N; pfam02861 1201010001463 Clp amino terminal domain; Region: Clp_N; pfam02861 1201010001464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010001465 Walker A motif; other site 1201010001466 ATP binding site [chemical binding]; other site 1201010001467 Walker B motif; other site 1201010001468 arginine finger; other site 1201010001469 UvrB/uvrC motif; Region: UVR; pfam02151 1201010001470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010001471 Walker A motif; other site 1201010001472 ATP binding site [chemical binding]; other site 1201010001473 Walker B motif; other site 1201010001474 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1201010001475 DNA repair protein RadA; Provisional; Region: PRK11823 1201010001476 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1201010001477 Walker A motif/ATP binding site; other site 1201010001478 ATP binding site [chemical binding]; other site 1201010001479 Walker B motif; other site 1201010001480 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1201010001481 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1201010001482 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1201010001483 putative active site [active] 1201010001484 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1201010001485 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1201010001486 active site 1201010001487 HIGH motif; other site 1201010001488 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1201010001489 active site 1201010001490 KMSKS motif; other site 1201010001491 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1201010001492 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1201010001493 trimer interface [polypeptide binding]; other site 1201010001494 active site 1201010001495 substrate binding site [chemical binding]; other site 1201010001496 CoA binding site [chemical binding]; other site 1201010001497 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1201010001498 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1201010001499 active site 1201010001500 HIGH motif; other site 1201010001501 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1201010001502 KMSKS motif; other site 1201010001503 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1201010001504 tRNA binding surface [nucleotide binding]; other site 1201010001505 anticodon binding site; other site 1201010001506 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1201010001507 active site 1201010001508 dimerization interface [polypeptide binding]; other site 1201010001509 metal binding site [ion binding]; metal-binding site 1201010001510 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1201010001511 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1201010001512 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1201010001513 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1201010001514 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1201010001515 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1201010001516 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1201010001517 DNA binding residues [nucleotide binding] 1201010001518 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1201010001519 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1201010001520 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1201010001521 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1201010001522 putative homodimer interface [polypeptide binding]; other site 1201010001523 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1201010001524 heterodimer interface [polypeptide binding]; other site 1201010001525 homodimer interface [polypeptide binding]; other site 1201010001526 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1201010001527 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1201010001528 23S rRNA interface [nucleotide binding]; other site 1201010001529 L7/L12 interface [polypeptide binding]; other site 1201010001530 putative thiostrepton binding site; other site 1201010001531 L25 interface [polypeptide binding]; other site 1201010001532 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1201010001533 mRNA/rRNA interface [nucleotide binding]; other site 1201010001534 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1201010001535 23S rRNA interface [nucleotide binding]; other site 1201010001536 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1201010001537 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1201010001538 peripheral dimer interface [polypeptide binding]; other site 1201010001539 core dimer interface [polypeptide binding]; other site 1201010001540 L10 interface [polypeptide binding]; other site 1201010001541 L11 interface [polypeptide binding]; other site 1201010001542 putative EF-Tu interaction site [polypeptide binding]; other site 1201010001543 putative EF-G interaction site [polypeptide binding]; other site 1201010001544 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1201010001545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010001546 S-adenosylmethionine binding site [chemical binding]; other site 1201010001547 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1201010001548 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1201010001549 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1201010001550 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1201010001551 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1201010001552 RPB10 interaction site [polypeptide binding]; other site 1201010001553 RPB1 interaction site [polypeptide binding]; other site 1201010001554 RPB11 interaction site [polypeptide binding]; other site 1201010001555 RPB3 interaction site [polypeptide binding]; other site 1201010001556 RPB12 interaction site [polypeptide binding]; other site 1201010001557 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1201010001558 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1201010001559 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1201010001560 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1201010001561 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1201010001562 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1201010001563 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1201010001564 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1201010001565 G-loop; other site 1201010001566 DNA binding site [nucleotide binding] 1201010001567 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1201010001568 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1201010001569 S17 interaction site [polypeptide binding]; other site 1201010001570 S8 interaction site; other site 1201010001571 16S rRNA interaction site [nucleotide binding]; other site 1201010001572 streptomycin interaction site [chemical binding]; other site 1201010001573 23S rRNA interaction site [nucleotide binding]; other site 1201010001574 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1201010001575 30S ribosomal protein S7; Validated; Region: PRK05302 1201010001576 elongation factor G; Reviewed; Region: PRK00007 1201010001577 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1201010001578 G1 box; other site 1201010001579 putative GEF interaction site [polypeptide binding]; other site 1201010001580 GTP/Mg2+ binding site [chemical binding]; other site 1201010001581 Switch I region; other site 1201010001582 G2 box; other site 1201010001583 G3 box; other site 1201010001584 Switch II region; other site 1201010001585 G4 box; other site 1201010001586 G5 box; other site 1201010001587 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1201010001588 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1201010001589 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1201010001590 elongation factor Tu; Reviewed; Region: PRK00049 1201010001591 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1201010001592 G1 box; other site 1201010001593 GEF interaction site [polypeptide binding]; other site 1201010001594 GTP/Mg2+ binding site [chemical binding]; other site 1201010001595 Switch I region; other site 1201010001596 G2 box; other site 1201010001597 G3 box; other site 1201010001598 Switch II region; other site 1201010001599 G4 box; other site 1201010001600 G5 box; other site 1201010001601 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1201010001602 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1201010001603 Antibiotic Binding Site [chemical binding]; other site 1201010001604 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1201010001605 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1201010001606 metal binding site [ion binding]; metal-binding site 1201010001607 dimer interface [polypeptide binding]; other site 1201010001608 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1201010001609 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1201010001610 substrate-cofactor binding pocket; other site 1201010001611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010001612 catalytic residue [active] 1201010001613 chaperone protein HchA; Provisional; Region: PRK04155 1201010001614 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1201010001615 conserved cys residue [active] 1201010001616 ribulokinase; Provisional; Region: PRK04123 1201010001617 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1201010001618 N- and C-terminal domain interface [polypeptide binding]; other site 1201010001619 active site 1201010001620 MgATP binding site [chemical binding]; other site 1201010001621 catalytic site [active] 1201010001622 metal binding site [ion binding]; metal-binding site 1201010001623 carbohydrate binding site [chemical binding]; other site 1201010001624 homodimer interface [polypeptide binding]; other site 1201010001625 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1201010001626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1201010001627 NAD(P) binding site [chemical binding]; other site 1201010001628 active site 1201010001629 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1201010001630 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1201010001631 homodimer interface [polypeptide binding]; other site 1201010001632 substrate-cofactor binding pocket; other site 1201010001633 catalytic residue [active] 1201010001634 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1201010001635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010001636 motif II; other site 1201010001637 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1201010001638 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1201010001639 Substrate-binding site [chemical binding]; other site 1201010001640 Substrate specificity [chemical binding]; other site 1201010001641 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1201010001642 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1201010001643 Substrate-binding site [chemical binding]; other site 1201010001644 Substrate specificity [chemical binding]; other site 1201010001645 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1201010001646 nucleoside/Zn binding site; other site 1201010001647 dimer interface [polypeptide binding]; other site 1201010001648 catalytic motif [active] 1201010001649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010001650 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1201010001651 active site 1201010001652 motif I; other site 1201010001653 motif II; other site 1201010001654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010001655 Predicted flavoprotein [General function prediction only]; Region: COG0431 1201010001656 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1201010001657 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1201010001658 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1201010001659 Cna protein B-type domain; Region: Cna_B; pfam05738 1201010001660 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1201010001661 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1201010001662 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1201010001663 Cna protein B-type domain; Region: Cna_B; pfam05738 1201010001664 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1201010001665 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1201010001666 Cna protein B-type domain; Region: Cna_B; pfam05738 1201010001667 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1201010001668 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1201010001669 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1201010001670 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1201010001671 Cna protein B-type domain; Region: Cna_B; pfam05738 1201010001672 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1201010001673 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1201010001674 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1201010001675 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1201010001676 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1201010001677 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1201010001678 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1201010001679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1201010001680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010001681 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1201010001682 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010001683 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1201010001684 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1201010001685 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1201010001686 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1201010001687 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1201010001688 active site 1201010001689 trimer interface [polypeptide binding]; other site 1201010001690 allosteric site; other site 1201010001691 active site lid [active] 1201010001692 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1201010001693 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1201010001694 active site 1201010001695 dimer interface [polypeptide binding]; other site 1201010001696 magnesium binding site [ion binding]; other site 1201010001697 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1201010001698 tetramer interface [polypeptide binding]; other site 1201010001699 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1201010001700 active site 1201010001701 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1201010001702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010001703 motif II; other site 1201010001704 proline/glycine betaine transporter; Provisional; Region: PRK10642 1201010001705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010001706 putative substrate translocation pore; other site 1201010001707 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1201010001708 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1201010001709 acyl-activating enzyme (AAE) consensus motif; other site 1201010001710 AMP binding site [chemical binding]; other site 1201010001711 active site 1201010001712 CoA binding site [chemical binding]; other site 1201010001713 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1201010001714 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1201010001715 dimer interface [polypeptide binding]; other site 1201010001716 active site 1201010001717 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1201010001718 dimer interface [polypeptide binding]; other site 1201010001719 substrate binding site [chemical binding]; other site 1201010001720 ATP binding site [chemical binding]; other site 1201010001721 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1201010001722 ligand binding site [chemical binding]; other site 1201010001723 active site 1201010001724 UGI interface [polypeptide binding]; other site 1201010001725 catalytic site [active] 1201010001726 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1201010001727 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1201010001728 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1201010001729 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1201010001730 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1201010001731 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1201010001732 putative heme peroxidase; Provisional; Region: PRK12276 1201010001733 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1201010001734 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1201010001735 mevalonate kinase; Region: mevalon_kin; TIGR00549 1201010001736 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1201010001737 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1201010001738 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1201010001739 diphosphomevalonate decarboxylase; Region: PLN02407 1201010001740 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1201010001741 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1201010001742 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1201010001743 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1201010001744 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1201010001745 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1201010001746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010001747 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1201010001748 Predicted transcriptional regulator [Transcription]; Region: COG1959 1201010001749 Transcriptional regulator; Region: Rrf2; pfam02082 1201010001750 LXG domain of WXG superfamily; Region: LXG; pfam04740 1201010001751 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1201010001752 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1201010001753 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1201010001754 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1201010001755 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1201010001756 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1201010001757 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1201010001758 active site 1201010001759 catalytic tetrad [active] 1201010001760 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1201010001761 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1201010001762 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1201010001763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010001764 Coenzyme A binding pocket [chemical binding]; other site 1201010001765 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1201010001766 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1201010001767 Zn2+ binding site [ion binding]; other site 1201010001768 Mg2+ binding site [ion binding]; other site 1201010001769 YwhD family; Region: YwhD; pfam08741 1201010001770 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1201010001771 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1201010001772 NAD binding site [chemical binding]; other site 1201010001773 substrate binding site [chemical binding]; other site 1201010001774 catalytic Zn binding site [ion binding]; other site 1201010001775 tetramer interface [polypeptide binding]; other site 1201010001776 structural Zn binding site [ion binding]; other site 1201010001777 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1201010001778 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1201010001779 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1201010001780 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1201010001781 active site 1201010001782 HIGH motif; other site 1201010001783 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1201010001784 KMSK motif region; other site 1201010001785 tRNA binding surface [nucleotide binding]; other site 1201010001786 DALR anticodon binding domain; Region: DALR_1; smart00836 1201010001787 anticodon binding site; other site 1201010001788 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1201010001789 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1201010001790 minor groove reading motif; other site 1201010001791 helix-hairpin-helix signature motif; other site 1201010001792 substrate binding pocket [chemical binding]; other site 1201010001793 active site 1201010001794 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1201010001795 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1201010001796 putative binding site residues; other site 1201010001797 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1201010001798 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1201010001799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010001800 ABC-ATPase subunit interface; other site 1201010001801 dimer interface [polypeptide binding]; other site 1201010001802 putative PBP binding regions; other site 1201010001803 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1201010001804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010001805 motif II; other site 1201010001806 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1201010001807 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1201010001808 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1201010001809 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1201010001810 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010001811 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1201010001812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1201010001813 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1201010001814 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1201010001815 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1201010001816 active site 1201010001817 DNA binding site [nucleotide binding] 1201010001818 Int/Topo IB signature motif; other site 1201010001819 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1201010001820 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1201010001821 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1201010001822 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1201010001823 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1201010001824 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1201010001825 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1201010001826 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1201010001827 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1201010001828 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1201010001829 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1201010001830 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1201010001831 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1201010001832 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1201010001833 metal binding site [ion binding]; metal-binding site 1201010001834 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1201010001835 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010001836 ABC-ATPase subunit interface; other site 1201010001837 dimer interface [polypeptide binding]; other site 1201010001838 putative PBP binding regions; other site 1201010001839 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1201010001840 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1201010001841 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1201010001842 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1201010001843 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1201010001844 FeoA domain; Region: FeoA; pfam04023 1201010001845 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1201010001846 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1201010001847 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1201010001848 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1201010001849 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1201010001850 Walker A/P-loop; other site 1201010001851 ATP binding site [chemical binding]; other site 1201010001852 Q-loop/lid; other site 1201010001853 ABC transporter signature motif; other site 1201010001854 Walker B; other site 1201010001855 D-loop; other site 1201010001856 H-loop/switch region; other site 1201010001857 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1201010001858 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1201010001859 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1201010001860 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1201010001861 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1201010001862 active site 1201010001863 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1201010001864 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1201010001865 active site 1201010001866 nucleotide binding site [chemical binding]; other site 1201010001867 HIGH motif; other site 1201010001868 KMSKS motif; other site 1201010001869 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1201010001870 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1201010001871 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1201010001872 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1201010001873 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1201010001874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010001875 Walker A/P-loop; other site 1201010001876 ATP binding site [chemical binding]; other site 1201010001877 Q-loop/lid; other site 1201010001878 ABC transporter signature motif; other site 1201010001879 Walker B; other site 1201010001880 D-loop; other site 1201010001881 H-loop/switch region; other site 1201010001882 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1201010001883 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1201010001884 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1201010001885 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1201010001886 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1201010001887 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1201010001888 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1201010001889 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1201010001890 Walker A/P-loop; other site 1201010001891 ATP binding site [chemical binding]; other site 1201010001892 Q-loop/lid; other site 1201010001893 ABC transporter signature motif; other site 1201010001894 Walker B; other site 1201010001895 D-loop; other site 1201010001896 H-loop/switch region; other site 1201010001897 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1201010001898 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010001899 ABC-ATPase subunit interface; other site 1201010001900 dimer interface [polypeptide binding]; other site 1201010001901 putative PBP binding regions; other site 1201010001902 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1201010001903 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010001904 ABC-ATPase subunit interface; other site 1201010001905 dimer interface [polypeptide binding]; other site 1201010001906 putative PBP binding regions; other site 1201010001907 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1201010001908 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1201010001909 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1201010001910 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1201010001911 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1201010001912 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1201010001913 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1201010001914 Na binding site [ion binding]; other site 1201010001915 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1201010001916 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1201010001917 substrate binding pocket [chemical binding]; other site 1201010001918 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1201010001919 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1201010001920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010001921 Coenzyme A binding pocket [chemical binding]; other site 1201010001922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1201010001923 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1201010001924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1201010001925 NAD(P) binding site [chemical binding]; other site 1201010001926 active site 1201010001927 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1201010001928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010001929 active site 1201010001930 phosphorylation site [posttranslational modification] 1201010001931 intermolecular recognition site; other site 1201010001932 dimerization interface [polypeptide binding]; other site 1201010001933 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1201010001934 DNA binding site [nucleotide binding] 1201010001935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1201010001936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1201010001937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010001938 ATP binding site [chemical binding]; other site 1201010001939 Mg2+ binding site [ion binding]; other site 1201010001940 G-X-G motif; other site 1201010001941 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1201010001942 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1201010001943 Walker A/P-loop; other site 1201010001944 ATP binding site [chemical binding]; other site 1201010001945 Q-loop/lid; other site 1201010001946 ABC transporter signature motif; other site 1201010001947 Walker B; other site 1201010001948 D-loop; other site 1201010001949 H-loop/switch region; other site 1201010001950 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1201010001951 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1201010001952 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1201010001953 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1201010001954 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1201010001955 Surface antigen [General function prediction only]; Region: COG3942 1201010001956 CHAP domain; Region: CHAP; pfam05257 1201010001957 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1201010001958 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1201010001959 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1201010001960 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010001961 hypothetical protein; Provisional; Region: PRK12378 1201010001962 Uncharacterized conserved protein [Function unknown]; Region: COG3542 1201010001963 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1201010001964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1201010001965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1201010001966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1201010001967 dimerization interface [polypeptide binding]; other site 1201010001968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010001969 sugar efflux transporter; Region: 2A0120; TIGR00899 1201010001970 putative substrate translocation pore; other site 1201010001971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1201010001972 Serine incorporator (Serinc); Region: Serinc; pfam03348 1201010001973 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1201010001974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010001975 Coenzyme A binding pocket [chemical binding]; other site 1201010001976 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1201010001977 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1201010001978 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1201010001979 hypothetical protein; Validated; Region: PRK00124 1201010001980 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1201010001981 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1201010001982 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1201010001983 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1201010001984 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1201010001985 Walker A/P-loop; other site 1201010001986 ATP binding site [chemical binding]; other site 1201010001987 Q-loop/lid; other site 1201010001988 ABC transporter signature motif; other site 1201010001989 Walker B; other site 1201010001990 D-loop; other site 1201010001991 H-loop/switch region; other site 1201010001992 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1201010001993 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1201010001994 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1201010001995 Walker A/P-loop; other site 1201010001996 ATP binding site [chemical binding]; other site 1201010001997 Q-loop/lid; other site 1201010001998 ABC transporter signature motif; other site 1201010001999 Walker B; other site 1201010002000 D-loop; other site 1201010002001 H-loop/switch region; other site 1201010002002 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1201010002003 MarR family; Region: MarR; pfam01047 1201010002004 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1201010002005 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1201010002006 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1201010002007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1201010002008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1201010002009 active site 1201010002010 catalytic tetrad [active] 1201010002011 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1201010002012 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1201010002013 transmembrane helices; other site 1201010002014 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1201010002015 DNA photolyase; Region: DNA_photolyase; pfam00875 1201010002016 Predicted membrane protein [Function unknown]; Region: COG4330 1201010002017 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1201010002018 trimer interface [polypeptide binding]; other site 1201010002019 putative Zn binding site [ion binding]; other site 1201010002020 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1201010002021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010002022 putative substrate translocation pore; other site 1201010002023 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1201010002024 putative deacylase active site [active] 1201010002025 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1201010002026 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1201010002027 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1201010002028 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1201010002029 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1201010002030 putative substrate binding site [chemical binding]; other site 1201010002031 putative ATP binding site [chemical binding]; other site 1201010002032 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1201010002033 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1201010002034 active site 1201010002035 phosphorylation site [posttranslational modification] 1201010002036 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1201010002037 active site 1201010002038 P-loop; other site 1201010002039 phosphorylation site [posttranslational modification] 1201010002040 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1201010002041 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1201010002042 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1201010002043 active site 1201010002044 dimer interface [polypeptide binding]; other site 1201010002045 Domain of unknown function DUF21; Region: DUF21; pfam01595 1201010002046 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1201010002047 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1201010002048 Transporter associated domain; Region: CorC_HlyC; pfam03471 1201010002049 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1201010002050 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1201010002051 active site 1201010002052 catalytic tetrad [active] 1201010002053 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1201010002054 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1201010002055 Ligand binding site; other site 1201010002056 Putative Catalytic site; other site 1201010002057 DXD motif; other site 1201010002058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1201010002059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1201010002060 dimer interface [polypeptide binding]; other site 1201010002061 phosphorylation site [posttranslational modification] 1201010002062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010002063 ATP binding site [chemical binding]; other site 1201010002064 Mg2+ binding site [ion binding]; other site 1201010002065 G-X-G motif; other site 1201010002066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1201010002067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010002068 active site 1201010002069 phosphorylation site [posttranslational modification] 1201010002070 intermolecular recognition site; other site 1201010002071 dimerization interface [polypeptide binding]; other site 1201010002072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1201010002073 DNA binding site [nucleotide binding] 1201010002074 DoxX; Region: DoxX; pfam07681 1201010002075 Electron transfer DM13; Region: DM13; pfam10517 1201010002076 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1201010002077 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1201010002078 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1201010002079 active site 1201010002080 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1201010002081 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1201010002082 Ligand Binding Site [chemical binding]; other site 1201010002083 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1201010002084 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1201010002085 glutamine binding [chemical binding]; other site 1201010002086 catalytic triad [active] 1201010002087 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1201010002088 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1201010002089 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1201010002090 substrate-cofactor binding pocket; other site 1201010002091 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1201010002092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010002093 catalytic residue [active] 1201010002094 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1201010002095 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1201010002096 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1201010002097 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1201010002098 Sulfatase; Region: Sulfatase; pfam00884 1201010002099 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1201010002100 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1201010002101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1201010002102 ABC transporter; Region: ABC_tran_2; pfam12848 1201010002103 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1201010002104 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1201010002105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010002106 ATP binding site [chemical binding]; other site 1201010002107 putative Mg++ binding site [ion binding]; other site 1201010002108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1201010002109 nucleotide binding region [chemical binding]; other site 1201010002110 ATP-binding site [chemical binding]; other site 1201010002111 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1201010002112 HRDC domain; Region: HRDC; pfam00570 1201010002113 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1201010002114 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1201010002115 Walker A/P-loop; other site 1201010002116 ATP binding site [chemical binding]; other site 1201010002117 Q-loop/lid; other site 1201010002118 ABC transporter signature motif; other site 1201010002119 Walker B; other site 1201010002120 D-loop; other site 1201010002121 H-loop/switch region; other site 1201010002122 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1201010002123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010002124 dimer interface [polypeptide binding]; other site 1201010002125 conserved gate region; other site 1201010002126 ABC-ATPase subunit interface; other site 1201010002127 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1201010002128 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1201010002129 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1201010002130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1201010002131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010002132 homodimer interface [polypeptide binding]; other site 1201010002133 catalytic residue [active] 1201010002134 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1201010002135 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1201010002136 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1201010002137 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1201010002138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010002139 putative substrate translocation pore; other site 1201010002140 POT family; Region: PTR2; cl17359 1201010002141 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1201010002142 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1201010002143 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1201010002144 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1201010002145 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1201010002146 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1201010002147 active site 1201010002148 dimer interface [polypeptide binding]; other site 1201010002149 catalytic residues [active] 1201010002150 effector binding site; other site 1201010002151 R2 peptide binding site; other site 1201010002152 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1201010002153 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1201010002154 dimer interface [polypeptide binding]; other site 1201010002155 putative radical transfer pathway; other site 1201010002156 diiron center [ion binding]; other site 1201010002157 tyrosyl radical; other site 1201010002158 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010002159 ABC-ATPase subunit interface; other site 1201010002160 dimer interface [polypeptide binding]; other site 1201010002161 putative PBP binding regions; other site 1201010002162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010002163 ABC-ATPase subunit interface; other site 1201010002164 dimer interface [polypeptide binding]; other site 1201010002165 putative PBP binding regions; other site 1201010002166 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1201010002167 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1201010002168 Walker A/P-loop; other site 1201010002169 ATP binding site [chemical binding]; other site 1201010002170 Q-loop/lid; other site 1201010002171 ABC transporter signature motif; other site 1201010002172 Walker B; other site 1201010002173 D-loop; other site 1201010002174 H-loop/switch region; other site 1201010002175 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1201010002176 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1201010002177 putative ligand binding residues [chemical binding]; other site 1201010002178 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1201010002179 FAD binding domain; Region: FAD_binding_4; pfam01565 1201010002180 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1201010002181 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1201010002182 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1201010002183 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1201010002184 peptidase T; Region: peptidase-T; TIGR01882 1201010002185 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1201010002186 metal binding site [ion binding]; metal-binding site 1201010002187 dimer interface [polypeptide binding]; other site 1201010002188 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1201010002189 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1201010002190 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1201010002191 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1201010002192 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1201010002193 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1201010002194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1201010002195 metal binding site [ion binding]; metal-binding site 1201010002196 active site 1201010002197 I-site; other site 1201010002198 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1201010002199 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1201010002200 Mg++ binding site [ion binding]; other site 1201010002201 putative catalytic motif [active] 1201010002202 substrate binding site [chemical binding]; other site 1201010002203 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1201010002204 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1201010002205 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1201010002206 EDD domain protein, DegV family; Region: DegV; TIGR00762 1201010002207 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1201010002208 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1201010002209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010002210 ATP binding site [chemical binding]; other site 1201010002211 putative Mg++ binding site [ion binding]; other site 1201010002212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1201010002213 nucleotide binding region [chemical binding]; other site 1201010002214 ATP-binding site [chemical binding]; other site 1201010002215 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1201010002216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1201010002217 active site 1201010002218 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1201010002219 30S subunit binding site; other site 1201010002220 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1201010002221 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1201010002222 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1201010002223 nucleotide binding region [chemical binding]; other site 1201010002224 ATP-binding site [chemical binding]; other site 1201010002225 SEC-C motif; Region: SEC-C; pfam02810 1201010002226 peptide chain release factor 2; Provisional; Region: PRK06746 1201010002227 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1201010002228 RF-1 domain; Region: RF-1; pfam00472 1201010002229 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1201010002230 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1201010002231 Surface antigen [General function prediction only]; Region: COG3942 1201010002232 CHAP domain; Region: CHAP; pfam05257 1201010002233 HD domain; Region: HD_3; cl17350 1201010002234 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1201010002235 excinuclease ABC subunit B; Provisional; Region: PRK05298 1201010002236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010002237 ATP binding site [chemical binding]; other site 1201010002238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1201010002239 nucleotide binding region [chemical binding]; other site 1201010002240 ATP-binding site [chemical binding]; other site 1201010002241 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1201010002242 UvrB/uvrC motif; Region: UVR; pfam02151 1201010002243 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1201010002244 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1201010002245 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1201010002246 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1201010002247 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1201010002248 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1201010002249 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1201010002250 Hpr binding site; other site 1201010002251 active site 1201010002252 homohexamer subunit interaction site [polypeptide binding]; other site 1201010002253 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1201010002254 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1201010002255 putative trimer interface [polypeptide binding]; other site 1201010002256 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1201010002257 putative CoA binding site [chemical binding]; other site 1201010002258 TPR repeat; Region: TPR_11; pfam13414 1201010002259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1201010002260 binding surface 1201010002261 TPR motif; other site 1201010002262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1201010002263 TPR motif; other site 1201010002264 binding surface 1201010002265 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1201010002266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1201010002267 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010002268 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1201010002269 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1201010002270 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1201010002271 phosphate binding site [ion binding]; other site 1201010002272 dimer interface [polypeptide binding]; other site 1201010002273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1201010002274 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1201010002275 Clp protease; Region: CLP_protease; pfam00574 1201010002276 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1201010002277 oligomer interface [polypeptide binding]; other site 1201010002278 active site residues [active] 1201010002279 malate dehydrogenase; Provisional; Region: PRK13529 1201010002280 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1201010002281 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1201010002282 NAD(P) binding site [chemical binding]; other site 1201010002283 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1201010002284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1201010002285 NAD(P) binding site [chemical binding]; other site 1201010002286 active site 1201010002287 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1201010002288 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1201010002289 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1201010002290 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1201010002291 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1201010002292 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1201010002293 Phosphoglycerate kinase; Region: PGK; pfam00162 1201010002294 substrate binding site [chemical binding]; other site 1201010002295 hinge regions; other site 1201010002296 ADP binding site [chemical binding]; other site 1201010002297 catalytic site [active] 1201010002298 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1201010002299 triosephosphate isomerase; Provisional; Region: PRK14565 1201010002300 substrate binding site [chemical binding]; other site 1201010002301 dimer interface [polypeptide binding]; other site 1201010002302 catalytic triad [active] 1201010002303 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1201010002304 phosphoglyceromutase; Provisional; Region: PRK05434 1201010002305 enolase; Provisional; Region: eno; PRK00077 1201010002306 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1201010002307 dimer interface [polypeptide binding]; other site 1201010002308 metal binding site [ion binding]; metal-binding site 1201010002309 substrate binding pocket [chemical binding]; other site 1201010002310 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1201010002311 Esterase/lipase [General function prediction only]; Region: COG1647 1201010002312 ribonuclease R; Region: RNase_R; TIGR02063 1201010002313 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1201010002314 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1201010002315 RNB domain; Region: RNB; pfam00773 1201010002316 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1201010002317 RNA binding site [nucleotide binding]; other site 1201010002318 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1201010002319 SmpB-tmRNA interface; other site 1201010002320 Integral membrane protein DUF95; Region: DUF95; cl00572 1201010002321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010002322 Coenzyme A binding pocket [chemical binding]; other site 1201010002323 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1201010002324 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1201010002325 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1201010002326 Staphylococcal nuclease homologues; Region: SNc; smart00318 1201010002327 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1201010002328 Catalytic site; other site 1201010002329 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1201010002330 DNA-binding site [nucleotide binding]; DNA binding site 1201010002331 RNA-binding motif; other site 1201010002332 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1201010002333 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1201010002334 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1201010002335 catalytic core [active] 1201010002336 Lysine efflux permease [General function prediction only]; Region: COG1279 1201010002337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1201010002338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1201010002339 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1201010002340 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1201010002341 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1201010002342 active site 1201010002343 catalytic residue [active] 1201010002344 dimer interface [polypeptide binding]; other site 1201010002345 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1201010002346 putative FMN binding site [chemical binding]; other site 1201010002347 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1201010002348 catalytic residues [active] 1201010002349 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1201010002350 ArsC family; Region: ArsC; pfam03960 1201010002351 putative ArsC-like catalytic residues; other site 1201010002352 putative TRX-like catalytic residues [active] 1201010002353 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1201010002354 lipoyl attachment site [posttranslational modification]; other site 1201010002355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1201010002356 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1201010002357 putative active site [active] 1201010002358 putative metal binding site [ion binding]; other site 1201010002359 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1201010002360 catalytic residues [active] 1201010002361 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1201010002362 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1201010002363 Walker A/P-loop; other site 1201010002364 ATP binding site [chemical binding]; other site 1201010002365 Q-loop/lid; other site 1201010002366 ABC transporter signature motif; other site 1201010002367 Walker B; other site 1201010002368 D-loop; other site 1201010002369 H-loop/switch region; other site 1201010002370 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1201010002371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010002372 dimer interface [polypeptide binding]; other site 1201010002373 conserved gate region; other site 1201010002374 ABC-ATPase subunit interface; other site 1201010002375 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1201010002376 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1201010002377 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1201010002378 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1201010002379 Int/Topo IB signature motif; other site 1201010002380 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1201010002381 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010002382 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1201010002383 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010002384 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1201010002385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010002386 non-specific DNA binding site [nucleotide binding]; other site 1201010002387 salt bridge; other site 1201010002388 sequence-specific DNA binding site [nucleotide binding]; other site 1201010002389 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010002390 non-specific DNA binding site [nucleotide binding]; other site 1201010002391 salt bridge; other site 1201010002392 sequence-specific DNA binding site [nucleotide binding]; other site 1201010002393 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1201010002394 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 1201010002395 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1201010002396 Virulence-associated protein E; Region: VirE; pfam05272 1201010002397 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1201010002398 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1201010002399 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1201010002400 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010002401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1201010002402 Predicted membrane protein [Function unknown]; Region: COG2035 1201010002403 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1201010002404 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1201010002405 Walker A/P-loop; other site 1201010002406 ATP binding site [chemical binding]; other site 1201010002407 Q-loop/lid; other site 1201010002408 ABC transporter signature motif; other site 1201010002409 Walker B; other site 1201010002410 D-loop; other site 1201010002411 H-loop/switch region; other site 1201010002412 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1201010002413 FeS assembly protein SufD; Region: sufD; TIGR01981 1201010002414 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1201010002415 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1201010002416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1201010002417 catalytic residue [active] 1201010002418 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1201010002419 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1201010002420 trimerization site [polypeptide binding]; other site 1201010002421 active site 1201010002422 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1201010002423 FeS assembly protein SufB; Region: sufB; TIGR01980 1201010002424 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1201010002425 Domain of unknown function DUF21; Region: DUF21; pfam01595 1201010002426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1201010002427 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1201010002428 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1201010002429 FMN binding site [chemical binding]; other site 1201010002430 substrate binding site [chemical binding]; other site 1201010002431 putative catalytic residue [active] 1201010002432 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1201010002433 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1201010002434 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1201010002435 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1201010002436 active site 1201010002437 metal binding site [ion binding]; metal-binding site 1201010002438 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1201010002439 lipoyl synthase; Provisional; Region: PRK05481 1201010002440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010002441 FeS/SAM binding site; other site 1201010002442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1201010002443 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1201010002444 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1201010002445 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1201010002446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010002447 active site 1201010002448 motif I; other site 1201010002449 motif II; other site 1201010002450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010002451 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1201010002452 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1201010002453 dimerization interface [polypeptide binding]; other site 1201010002454 ligand binding site [chemical binding]; other site 1201010002455 NADP binding site [chemical binding]; other site 1201010002456 catalytic site [active] 1201010002457 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1201010002458 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1201010002459 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1201010002460 acyl-activating enzyme (AAE) consensus motif; other site 1201010002461 AMP binding site [chemical binding]; other site 1201010002462 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1201010002463 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1201010002464 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1201010002465 DltD N-terminal region; Region: DltD_N; pfam04915 1201010002466 DltD central region; Region: DltD_M; pfam04918 1201010002467 DltD C-terminal region; Region: DltD_C; pfam04914 1201010002468 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1201010002469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1201010002470 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1201010002471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010002472 hypothetical protein; Provisional; Region: PRK13669 1201010002473 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1201010002474 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1201010002475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010002476 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1201010002477 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1201010002478 interface (dimer of trimers) [polypeptide binding]; other site 1201010002479 Substrate-binding/catalytic site; other site 1201010002480 Zn-binding sites [ion binding]; other site 1201010002481 Predicted permease [General function prediction only]; Region: COG2056 1201010002482 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1201010002483 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1201010002484 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1201010002485 CoenzymeA binding site [chemical binding]; other site 1201010002486 subunit interaction site [polypeptide binding]; other site 1201010002487 PHB binding site; other site 1201010002488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1201010002489 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1201010002490 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1201010002491 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1201010002492 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1201010002493 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1201010002494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1201010002495 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1201010002496 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1201010002497 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1201010002498 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1201010002499 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1201010002500 Kinase associated protein B; Region: KapB; pfam08810 1201010002501 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1201010002502 active site 1201010002503 general stress protein 13; Validated; Region: PRK08059 1201010002504 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1201010002505 RNA binding site [nucleotide binding]; other site 1201010002506 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1201010002507 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1201010002508 putative active site [active] 1201010002509 putative FMN binding site [chemical binding]; other site 1201010002510 putative substrate binding site [chemical binding]; other site 1201010002511 putative catalytic residue [active] 1201010002512 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1201010002513 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1201010002514 inhibitor-cofactor binding pocket; inhibition site 1201010002515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010002516 catalytic residue [active] 1201010002517 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1201010002518 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1201010002519 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1201010002520 NAD(P) binding site [chemical binding]; other site 1201010002521 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1201010002522 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1201010002523 active site 1201010002524 catalytic site [active] 1201010002525 metal binding site [ion binding]; metal-binding site 1201010002526 argininosuccinate lyase; Provisional; Region: PRK00855 1201010002527 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1201010002528 active sites [active] 1201010002529 tetramer interface [polypeptide binding]; other site 1201010002530 argininosuccinate synthase; Provisional; Region: PRK13820 1201010002531 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1201010002532 ANP binding site [chemical binding]; other site 1201010002533 Substrate Binding Site II [chemical binding]; other site 1201010002534 Substrate Binding Site I [chemical binding]; other site 1201010002535 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1201010002536 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1201010002537 active site 1201010002538 dimer interface [polypeptide binding]; other site 1201010002539 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1201010002540 dimer interface [polypeptide binding]; other site 1201010002541 active site 1201010002542 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1201010002543 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1201010002544 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1201010002545 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1201010002546 Catalytic site [active] 1201010002547 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1201010002548 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1201010002549 Catalytic site [active] 1201010002550 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1201010002551 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1201010002552 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1201010002553 Part of AAA domain; Region: AAA_19; pfam13245 1201010002554 Family description; Region: UvrD_C_2; pfam13538 1201010002555 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1201010002556 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1201010002557 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1201010002558 hypothetical protein; Provisional; Region: PRK13673 1201010002559 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1201010002560 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1201010002561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010002562 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1201010002563 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1201010002564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010002565 active site 1201010002566 motif I; other site 1201010002567 motif II; other site 1201010002568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010002569 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1201010002570 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1201010002571 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1201010002572 catalytic triad [active] 1201010002573 catalytic triad [active] 1201010002574 oxyanion hole [active] 1201010002575 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1201010002576 Clp amino terminal domain; Region: Clp_N; pfam02861 1201010002577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010002578 Walker A motif; other site 1201010002579 ATP binding site [chemical binding]; other site 1201010002580 Walker B motif; other site 1201010002581 arginine finger; other site 1201010002582 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1201010002583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010002584 Walker A motif; other site 1201010002585 ATP binding site [chemical binding]; other site 1201010002586 Walker B motif; other site 1201010002587 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1201010002588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1201010002589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1201010002590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1201010002591 dimerization interface [polypeptide binding]; other site 1201010002592 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1201010002593 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1201010002594 active site 1201010002595 catalytic residues [active] 1201010002596 metal binding site [ion binding]; metal-binding site 1201010002597 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1201010002598 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1201010002599 substrate binding site [chemical binding]; other site 1201010002600 MAP domain; Region: MAP; pfam03642 1201010002601 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1201010002602 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1201010002603 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1201010002604 dimer interface [polypeptide binding]; other site 1201010002605 active site 1201010002606 CoA binding pocket [chemical binding]; other site 1201010002607 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1201010002608 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1201010002609 dimer interface [polypeptide binding]; other site 1201010002610 active site 1201010002611 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1201010002612 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1201010002613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010002614 dimer interface [polypeptide binding]; other site 1201010002615 conserved gate region; other site 1201010002616 putative PBP binding loops; other site 1201010002617 ABC-ATPase subunit interface; other site 1201010002618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1201010002619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010002620 dimer interface [polypeptide binding]; other site 1201010002621 conserved gate region; other site 1201010002622 putative PBP binding loops; other site 1201010002623 ABC-ATPase subunit interface; other site 1201010002624 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1201010002625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010002626 Walker A/P-loop; other site 1201010002627 ATP binding site [chemical binding]; other site 1201010002628 Q-loop/lid; other site 1201010002629 ABC transporter signature motif; other site 1201010002630 Walker B; other site 1201010002631 D-loop; other site 1201010002632 H-loop/switch region; other site 1201010002633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1201010002634 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1201010002635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010002636 Walker A/P-loop; other site 1201010002637 ATP binding site [chemical binding]; other site 1201010002638 Q-loop/lid; other site 1201010002639 ABC transporter signature motif; other site 1201010002640 Walker B; other site 1201010002641 D-loop; other site 1201010002642 H-loop/switch region; other site 1201010002643 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1201010002644 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1201010002645 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1201010002646 peptide binding site [polypeptide binding]; other site 1201010002647 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1201010002648 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1201010002649 peptide binding site [polypeptide binding]; other site 1201010002650 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1201010002651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010002652 Walker A/P-loop; other site 1201010002653 ATP binding site [chemical binding]; other site 1201010002654 Q-loop/lid; other site 1201010002655 ABC transporter signature motif; other site 1201010002656 Walker B; other site 1201010002657 D-loop; other site 1201010002658 H-loop/switch region; other site 1201010002659 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1201010002660 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1201010002661 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010002662 Walker A/P-loop; other site 1201010002663 ATP binding site [chemical binding]; other site 1201010002664 Q-loop/lid; other site 1201010002665 ABC transporter signature motif; other site 1201010002666 Walker B; other site 1201010002667 D-loop; other site 1201010002668 H-loop/switch region; other site 1201010002669 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1201010002670 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1201010002671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010002672 dimer interface [polypeptide binding]; other site 1201010002673 conserved gate region; other site 1201010002674 putative PBP binding loops; other site 1201010002675 ABC-ATPase subunit interface; other site 1201010002676 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1201010002677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010002678 dimer interface [polypeptide binding]; other site 1201010002679 conserved gate region; other site 1201010002680 putative PBP binding loops; other site 1201010002681 ABC-ATPase subunit interface; other site 1201010002682 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1201010002683 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1201010002684 active site 1201010002685 HIGH motif; other site 1201010002686 dimer interface [polypeptide binding]; other site 1201010002687 KMSKS motif; other site 1201010002688 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1201010002689 ArsC family; Region: ArsC; pfam03960 1201010002690 putative catalytic residues [active] 1201010002691 thiol/disulfide switch; other site 1201010002692 adaptor protein; Provisional; Region: PRK02315 1201010002693 Competence protein CoiA-like family; Region: CoiA; cl11541 1201010002694 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1201010002695 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1201010002696 active site 1201010002697 Zn binding site [ion binding]; other site 1201010002698 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1201010002699 Thioredoxin; Region: Thioredoxin_5; pfam13743 1201010002700 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1201010002701 apolar tunnel; other site 1201010002702 heme binding site [chemical binding]; other site 1201010002703 dimerization interface [polypeptide binding]; other site 1201010002704 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1201010002705 putative active site [active] 1201010002706 putative metal binding residues [ion binding]; other site 1201010002707 signature motif; other site 1201010002708 putative triphosphate binding site [ion binding]; other site 1201010002709 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1201010002710 synthetase active site [active] 1201010002711 NTP binding site [chemical binding]; other site 1201010002712 metal binding site [ion binding]; metal-binding site 1201010002713 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1201010002714 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1201010002715 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1201010002716 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1201010002717 active site 1201010002718 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1201010002719 MgtE intracellular N domain; Region: MgtE_N; smart00924 1201010002720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1201010002721 Divalent cation transporter; Region: MgtE; pfam01769 1201010002722 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1201010002723 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1201010002724 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1201010002725 TrkA-N domain; Region: TrkA_N; pfam02254 1201010002726 TrkA-C domain; Region: TrkA_C; pfam02080 1201010002727 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1201010002728 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1201010002729 NAD binding site [chemical binding]; other site 1201010002730 homotetramer interface [polypeptide binding]; other site 1201010002731 homodimer interface [polypeptide binding]; other site 1201010002732 substrate binding site [chemical binding]; other site 1201010002733 active site 1201010002734 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1201010002735 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1201010002736 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1201010002737 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1201010002738 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1201010002739 Putative esterase; Region: Esterase; pfam00756 1201010002740 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1201010002741 minor groove reading motif; other site 1201010002742 helix-hairpin-helix signature motif; other site 1201010002743 substrate binding pocket [chemical binding]; other site 1201010002744 active site 1201010002745 hypothetical protein; Provisional; Region: PRK13679 1201010002746 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1201010002747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010002748 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010002749 putative substrate translocation pore; other site 1201010002750 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1201010002751 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1201010002752 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1201010002753 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1201010002754 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1201010002755 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1201010002756 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1201010002757 YueH-like protein; Region: YueH; pfam14166 1201010002758 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1201010002759 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1201010002760 G1 box; other site 1201010002761 putative GEF interaction site [polypeptide binding]; other site 1201010002762 GTP/Mg2+ binding site [chemical binding]; other site 1201010002763 Switch I region; other site 1201010002764 G2 box; other site 1201010002765 G3 box; other site 1201010002766 Switch II region; other site 1201010002767 G4 box; other site 1201010002768 G5 box; other site 1201010002769 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1201010002770 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1201010002771 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1201010002772 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1201010002773 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1201010002774 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1201010002775 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1201010002776 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1201010002777 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1201010002778 active site 1201010002779 metal binding site [ion binding]; metal-binding site 1201010002780 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1201010002781 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1201010002782 IDEAL domain; Region: IDEAL; pfam08858 1201010002783 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1201010002784 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1201010002785 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1201010002786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1201010002787 CAAX protease self-immunity; Region: Abi; pfam02517 1201010002788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1201010002789 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010002790 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1201010002791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010002792 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1201010002793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1201010002794 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1201010002795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1201010002796 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1201010002797 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1201010002798 Walker A/P-loop; other site 1201010002799 ATP binding site [chemical binding]; other site 1201010002800 Q-loop/lid; other site 1201010002801 ABC transporter signature motif; other site 1201010002802 Walker B; other site 1201010002803 D-loop; other site 1201010002804 H-loop/switch region; other site 1201010002805 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1201010002806 Predicted membrane protein [Function unknown]; Region: COG2259 1201010002807 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1201010002808 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1201010002809 siderophore binding site; other site 1201010002810 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1201010002811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010002812 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1201010002813 Coenzyme A binding pocket [chemical binding]; other site 1201010002814 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1201010002815 UbiA prenyltransferase family; Region: UbiA; pfam01040 1201010002816 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1201010002817 isochorismate synthases; Region: isochor_syn; TIGR00543 1201010002818 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1201010002819 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1201010002820 dimer interface [polypeptide binding]; other site 1201010002821 tetramer interface [polypeptide binding]; other site 1201010002822 PYR/PP interface [polypeptide binding]; other site 1201010002823 TPP binding site [chemical binding]; other site 1201010002824 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1201010002825 TPP-binding site; other site 1201010002826 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1201010002827 PGAP1-like protein; Region: PGAP1; pfam07819 1201010002828 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1201010002829 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1201010002830 substrate binding site [chemical binding]; other site 1201010002831 oxyanion hole (OAH) forming residues; other site 1201010002832 trimer interface [polypeptide binding]; other site 1201010002833 Staphostatin B; Region: Staphostatin_B; pfam09023 1201010002834 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1201010002835 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1201010002836 aminotransferase A; Validated; Region: PRK07683 1201010002837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1201010002838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010002839 homodimer interface [polypeptide binding]; other site 1201010002840 catalytic residue [active] 1201010002841 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1201010002842 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1201010002843 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1201010002844 MarR family; Region: MarR; pfam01047 1201010002845 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1201010002846 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1201010002847 amidase catalytic site [active] 1201010002848 Zn binding residues [ion binding]; other site 1201010002849 substrate binding site [chemical binding]; other site 1201010002850 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1201010002851 Lysozyme subfamily 2; Region: LYZ2; smart00047 1201010002852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010002853 Coenzyme A binding pocket [chemical binding]; other site 1201010002854 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1201010002855 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1201010002856 Beta-lactamase; Region: Beta-lactamase; pfam00144 1201010002857 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1201010002858 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1201010002859 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1201010002860 Subunit I/III interface [polypeptide binding]; other site 1201010002861 Subunit III/IV interface [polypeptide binding]; other site 1201010002862 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1201010002863 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1201010002864 D-pathway; other site 1201010002865 Putative ubiquinol binding site [chemical binding]; other site 1201010002866 Low-spin heme (heme b) binding site [chemical binding]; other site 1201010002867 Putative water exit pathway; other site 1201010002868 Binuclear center (heme o3/CuB) [ion binding]; other site 1201010002869 K-pathway; other site 1201010002870 Putative proton exit pathway; other site 1201010002871 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1201010002872 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1201010002873 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1201010002874 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1201010002875 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1201010002876 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1201010002877 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1201010002878 homodimer interface [polypeptide binding]; other site 1201010002879 NADP binding site [chemical binding]; other site 1201010002880 substrate binding site [chemical binding]; other site 1201010002881 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1201010002882 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1201010002883 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1201010002884 NAD binding site [chemical binding]; other site 1201010002885 ATP-grasp domain; Region: ATP-grasp; pfam02222 1201010002886 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1201010002887 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1201010002888 ATP binding site [chemical binding]; other site 1201010002889 active site 1201010002890 substrate binding site [chemical binding]; other site 1201010002891 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1201010002892 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1201010002893 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1201010002894 putative active site [active] 1201010002895 catalytic triad [active] 1201010002896 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1201010002897 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1201010002898 dimerization interface [polypeptide binding]; other site 1201010002899 ATP binding site [chemical binding]; other site 1201010002900 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1201010002901 dimerization interface [polypeptide binding]; other site 1201010002902 ATP binding site [chemical binding]; other site 1201010002903 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1201010002904 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1201010002905 active site 1201010002906 tetramer interface [polypeptide binding]; other site 1201010002907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1201010002908 active site 1201010002909 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1201010002910 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1201010002911 dimerization interface [polypeptide binding]; other site 1201010002912 putative ATP binding site [chemical binding]; other site 1201010002913 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1201010002914 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1201010002915 active site 1201010002916 substrate binding site [chemical binding]; other site 1201010002917 cosubstrate binding site; other site 1201010002918 catalytic site [active] 1201010002919 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1201010002920 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1201010002921 purine monophosphate binding site [chemical binding]; other site 1201010002922 dimer interface [polypeptide binding]; other site 1201010002923 putative catalytic residues [active] 1201010002924 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1201010002925 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1201010002926 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1201010002927 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1201010002928 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1201010002929 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1201010002930 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1201010002931 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1201010002932 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1201010002933 Walker A/P-loop; other site 1201010002934 ATP binding site [chemical binding]; other site 1201010002935 Q-loop/lid; other site 1201010002936 ABC transporter signature motif; other site 1201010002937 Walker B; other site 1201010002938 D-loop; other site 1201010002939 H-loop/switch region; other site 1201010002940 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1201010002941 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1201010002942 Walker A/P-loop; other site 1201010002943 ATP binding site [chemical binding]; other site 1201010002944 Q-loop/lid; other site 1201010002945 ABC transporter signature motif; other site 1201010002946 Walker B; other site 1201010002947 D-loop; other site 1201010002948 H-loop/switch region; other site 1201010002949 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1201010002950 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1201010002951 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1201010002952 putative RNA binding site [nucleotide binding]; other site 1201010002953 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1201010002954 Domain of unknown function (DUF697); Region: DUF697; cl12064 1201010002955 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1201010002956 dimerization domain swap beta strand [polypeptide binding]; other site 1201010002957 regulatory protein interface [polypeptide binding]; other site 1201010002958 active site 1201010002959 regulatory phosphorylation site [posttranslational modification]; other site 1201010002960 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1201010002961 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1201010002962 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1201010002963 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1201010002964 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1201010002965 catalytic residues [active] 1201010002966 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1201010002967 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1201010002968 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1201010002969 TrkA-N domain; Region: TrkA_N; pfam02254 1201010002970 TrkA-C domain; Region: TrkA_C; pfam02080 1201010002971 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1201010002972 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1201010002973 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1201010002974 hypothetical protein; Provisional; Region: PRK13667 1201010002975 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1201010002976 active site 1201010002977 catalytic residues [active] 1201010002978 metal binding site [ion binding]; metal-binding site 1201010002979 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1201010002980 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1201010002981 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1201010002982 TPP-binding site [chemical binding]; other site 1201010002983 tetramer interface [polypeptide binding]; other site 1201010002984 heterodimer interface [polypeptide binding]; other site 1201010002985 phosphorylation loop region [posttranslational modification] 1201010002986 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1201010002987 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1201010002988 alpha subunit interface [polypeptide binding]; other site 1201010002989 TPP binding site [chemical binding]; other site 1201010002990 heterodimer interface [polypeptide binding]; other site 1201010002991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1201010002992 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1201010002993 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1201010002994 E3 interaction surface; other site 1201010002995 lipoyl attachment site [posttranslational modification]; other site 1201010002996 e3 binding domain; Region: E3_binding; pfam02817 1201010002997 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1201010002998 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1201010002999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1201010003000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010003001 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1201010003002 hypothetical protein; Provisional; Region: PRK04387 1201010003003 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1201010003004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010003005 non-specific DNA binding site [nucleotide binding]; other site 1201010003006 salt bridge; other site 1201010003007 sequence-specific DNA binding site [nucleotide binding]; other site 1201010003008 Cupin domain; Region: Cupin_2; pfam07883 1201010003009 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1201010003010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010003011 Walker A/P-loop; other site 1201010003012 ATP binding site [chemical binding]; other site 1201010003013 Q-loop/lid; other site 1201010003014 ABC transporter signature motif; other site 1201010003015 Walker B; other site 1201010003016 D-loop; other site 1201010003017 H-loop/switch region; other site 1201010003018 TOBE domain; Region: TOBE_2; pfam08402 1201010003019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010003020 putative PBP binding loops; other site 1201010003021 dimer interface [polypeptide binding]; other site 1201010003022 ABC-ATPase subunit interface; other site 1201010003023 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1201010003024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010003025 dimer interface [polypeptide binding]; other site 1201010003026 conserved gate region; other site 1201010003027 putative PBP binding loops; other site 1201010003028 ABC-ATPase subunit interface; other site 1201010003029 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1201010003030 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 1201010003031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1201010003032 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1201010003033 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1201010003034 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1201010003035 manganese transport protein MntH; Reviewed; Region: PRK00701 1201010003036 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1201010003037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1201010003038 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1201010003039 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1201010003040 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1201010003041 active site 1201010003042 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1201010003043 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1201010003044 G1 box; other site 1201010003045 putative GEF interaction site [polypeptide binding]; other site 1201010003046 GTP/Mg2+ binding site [chemical binding]; other site 1201010003047 Switch I region; other site 1201010003048 G2 box; other site 1201010003049 G3 box; other site 1201010003050 Switch II region; other site 1201010003051 G4 box; other site 1201010003052 G5 box; other site 1201010003053 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1201010003054 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1201010003055 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1201010003056 hypothetical protein; Provisional; Region: PRK13666 1201010003057 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1201010003058 pyruvate carboxylase; Reviewed; Region: PRK12999 1201010003059 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1201010003060 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1201010003061 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1201010003062 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1201010003063 active site 1201010003064 catalytic residues [active] 1201010003065 metal binding site [ion binding]; metal-binding site 1201010003066 homodimer binding site [polypeptide binding]; other site 1201010003067 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1201010003068 carboxyltransferase (CT) interaction site; other site 1201010003069 biotinylation site [posttranslational modification]; other site 1201010003070 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1201010003071 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1201010003072 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1201010003073 UbiA prenyltransferase family; Region: UbiA; pfam01040 1201010003074 Predicted membrane protein [Function unknown]; Region: COG2322 1201010003075 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1201010003076 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1201010003077 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1201010003078 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1201010003079 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1201010003080 putative active site [active] 1201010003081 catalytic site [active] 1201010003082 putative metal binding site [ion binding]; other site 1201010003083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1201010003084 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1201010003085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010003086 S-adenosylmethionine binding site [chemical binding]; other site 1201010003087 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1201010003088 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1201010003089 active site 1201010003090 (T/H)XGH motif; other site 1201010003091 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1201010003092 hypothetical protein; Provisional; Region: PRK13670 1201010003093 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1201010003094 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1201010003095 heme uptake protein IsdB; Region: IsdB; TIGR03657 1201010003096 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1201010003097 NEAr Transporter domain; Region: NEAT; smart00725 1201010003098 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1201010003099 heme-binding site [chemical binding]; other site 1201010003100 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1201010003101 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1201010003102 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1201010003103 heme-binding site [chemical binding]; other site 1201010003104 heme uptake protein IsdC; Region: IsdC; TIGR03656 1201010003105 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1201010003106 heme-binding site [chemical binding]; other site 1201010003107 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1201010003108 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1201010003109 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1201010003110 intersubunit interface [polypeptide binding]; other site 1201010003111 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1201010003112 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010003113 ABC-ATPase subunit interface; other site 1201010003114 dimer interface [polypeptide binding]; other site 1201010003115 putative PBP binding regions; other site 1201010003116 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1201010003117 active site 1201010003118 catalytic site [active] 1201010003119 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 1201010003120 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1201010003121 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1201010003122 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1201010003123 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1201010003124 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1201010003125 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1201010003126 dimer interface [polypeptide binding]; other site 1201010003127 motif 1; other site 1201010003128 active site 1201010003129 motif 2; other site 1201010003130 motif 3; other site 1201010003131 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1201010003132 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1201010003133 putative tRNA-binding site [nucleotide binding]; other site 1201010003134 B3/4 domain; Region: B3_4; pfam03483 1201010003135 tRNA synthetase B5 domain; Region: B5; smart00874 1201010003136 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1201010003137 dimer interface [polypeptide binding]; other site 1201010003138 motif 1; other site 1201010003139 motif 3; other site 1201010003140 motif 2; other site 1201010003141 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1201010003142 ribonuclease HIII; Provisional; Region: PRK00996 1201010003143 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1201010003144 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1201010003145 RNA/DNA hybrid binding site [nucleotide binding]; other site 1201010003146 active site 1201010003147 Cell division protein ZapA; Region: ZapA; cl01146 1201010003148 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1201010003149 Colicin V production protein; Region: Colicin_V; pfam02674 1201010003150 hypothetical protein; Provisional; Region: PRK08609 1201010003151 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1201010003152 active site 1201010003153 primer binding site [nucleotide binding]; other site 1201010003154 NTP binding site [chemical binding]; other site 1201010003155 metal binding triad [ion binding]; metal-binding site 1201010003156 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1201010003157 active site 1201010003158 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1201010003159 MutS domain III; Region: MutS_III; pfam05192 1201010003160 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1201010003161 Walker A/P-loop; other site 1201010003162 ATP binding site [chemical binding]; other site 1201010003163 Q-loop/lid; other site 1201010003164 ABC transporter signature motif; other site 1201010003165 Walker B; other site 1201010003166 D-loop; other site 1201010003167 H-loop/switch region; other site 1201010003168 Smr domain; Region: Smr; pfam01713 1201010003169 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1201010003170 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1201010003171 catalytic residues [active] 1201010003172 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1201010003173 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1201010003174 GIY-YIG motif/motif A; other site 1201010003175 active site 1201010003176 catalytic site [active] 1201010003177 putative DNA binding site [nucleotide binding]; other site 1201010003178 metal binding site [ion binding]; metal-binding site 1201010003179 UvrB/uvrC motif; Region: UVR; pfam02151 1201010003180 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1201010003181 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1201010003182 putative Iron-sulfur protein interface [polypeptide binding]; other site 1201010003183 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1201010003184 proximal heme binding site [chemical binding]; other site 1201010003185 distal heme binding site [chemical binding]; other site 1201010003186 putative dimer interface [polypeptide binding]; other site 1201010003187 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1201010003188 L-aspartate oxidase; Provisional; Region: PRK06175 1201010003189 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1201010003190 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1201010003191 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1201010003192 glutamate racemase; Provisional; Region: PRK00865 1201010003193 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1201010003194 active site 1201010003195 dimerization interface [polypeptide binding]; other site 1201010003196 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1201010003197 active site 1201010003198 metal binding site [ion binding]; metal-binding site 1201010003199 homotetramer interface [polypeptide binding]; other site 1201010003200 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1201010003201 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 1201010003202 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1201010003203 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1201010003204 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1201010003205 superantigen-like protein; Reviewed; Region: PRK13350 1201010003206 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010003207 superantigen-like protein; Reviewed; Region: PRK13349 1201010003208 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010003209 superantigen-like protein; Reviewed; Region: PRK13043 1201010003210 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010003211 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1201010003212 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1201010003213 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1201010003214 carbamate kinase; Reviewed; Region: PRK12686 1201010003215 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1201010003216 putative substrate binding site [chemical binding]; other site 1201010003217 nucleotide binding site [chemical binding]; other site 1201010003218 nucleotide binding site [chemical binding]; other site 1201010003219 homodimer interface [polypeptide binding]; other site 1201010003220 Predicted membrane protein [Function unknown]; Region: COG1288 1201010003221 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1201010003222 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1201010003223 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1201010003224 gating phenylalanine in ion channel; other site 1201010003225 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1201010003226 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1201010003227 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1201010003228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010003229 motif II; other site 1201010003230 hypothetical protein; Provisional; Region: PRK13688 1201010003231 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1201010003232 Coenzyme A binding pocket [chemical binding]; other site 1201010003233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1201010003234 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1201010003235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1201010003236 MraZ protein; Region: MraZ; pfam02381 1201010003237 MraZ protein; Region: MraZ; pfam02381 1201010003238 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1201010003239 MraW methylase family; Region: Methyltransf_5; pfam01795 1201010003240 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1201010003241 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1201010003242 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1201010003243 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1201010003244 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1201010003245 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1201010003246 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1201010003247 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1201010003248 Mg++ binding site [ion binding]; other site 1201010003249 putative catalytic motif [active] 1201010003250 putative substrate binding site [chemical binding]; other site 1201010003251 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1201010003252 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1201010003253 NAD binding site [chemical binding]; other site 1201010003254 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1201010003255 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1201010003256 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1201010003257 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1201010003258 Cell division protein FtsQ; Region: FtsQ; pfam03799 1201010003259 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1201010003260 Cell division protein FtsA; Region: FtsA; smart00842 1201010003261 Cell division protein FtsA; Region: FtsA; pfam14450 1201010003262 cell division protein FtsZ; Validated; Region: PRK09330 1201010003263 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1201010003264 nucleotide binding site [chemical binding]; other site 1201010003265 SulA interaction site; other site 1201010003266 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1201010003267 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1201010003268 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1201010003269 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1201010003270 catalytic residue [active] 1201010003271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1201010003272 YGGT family; Region: YGGT; pfam02325 1201010003273 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1201010003274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1201010003275 RNA binding surface [nucleotide binding]; other site 1201010003276 DivIVA protein; Region: DivIVA; pfam05103 1201010003277 DivIVA domain; Region: DivI1A_domain; TIGR03544 1201010003278 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1201010003279 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1201010003280 HIGH motif; other site 1201010003281 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1201010003282 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1201010003283 active site 1201010003284 KMSKS motif; other site 1201010003285 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1201010003286 tRNA binding surface [nucleotide binding]; other site 1201010003287 anticodon binding site; other site 1201010003288 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1201010003289 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1201010003290 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1201010003291 active site 1201010003292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1201010003293 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010003294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1201010003295 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1201010003296 lipoprotein signal peptidase; Provisional; Region: PRK14787 1201010003297 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1201010003298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1201010003299 RNA binding surface [nucleotide binding]; other site 1201010003300 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1201010003301 active site 1201010003302 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1201010003303 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1201010003304 uracil transporter; Provisional; Region: PRK10720 1201010003305 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1201010003306 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1201010003307 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1201010003308 dihydroorotase; Validated; Region: pyrC; PRK09357 1201010003309 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1201010003310 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1201010003311 active site 1201010003312 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1201010003313 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1201010003314 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1201010003315 catalytic site [active] 1201010003316 subunit interface [polypeptide binding]; other site 1201010003317 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1201010003318 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1201010003319 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1201010003320 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1201010003321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1201010003322 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1201010003323 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1201010003324 IMP binding site; other site 1201010003325 dimer interface [polypeptide binding]; other site 1201010003326 interdomain contacts; other site 1201010003327 partial ornithine binding site; other site 1201010003328 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1201010003329 active site 1201010003330 dimer interface [polypeptide binding]; other site 1201010003331 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1201010003332 active site 1201010003333 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1201010003334 dimer interface [polypeptide binding]; other site 1201010003335 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1201010003336 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1201010003337 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1201010003338 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1201010003339 catalytic site [active] 1201010003340 G-X2-G-X-G-K; other site 1201010003341 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1201010003342 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1201010003343 Flavoprotein; Region: Flavoprotein; pfam02441 1201010003344 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1201010003345 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1201010003346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010003347 ATP binding site [chemical binding]; other site 1201010003348 putative Mg++ binding site [ion binding]; other site 1201010003349 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1201010003350 nucleotide binding region [chemical binding]; other site 1201010003351 ATP-binding site [chemical binding]; other site 1201010003352 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1201010003353 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1201010003354 active site 1201010003355 catalytic residues [active] 1201010003356 metal binding site [ion binding]; metal-binding site 1201010003357 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1201010003358 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1201010003359 putative active site [active] 1201010003360 substrate binding site [chemical binding]; other site 1201010003361 putative cosubstrate binding site; other site 1201010003362 catalytic site [active] 1201010003363 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1201010003364 substrate binding site [chemical binding]; other site 1201010003365 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1201010003366 NusB family; Region: NusB; pfam01029 1201010003367 putative RNA binding site [nucleotide binding]; other site 1201010003368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010003369 S-adenosylmethionine binding site [chemical binding]; other site 1201010003370 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1201010003371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010003372 FeS/SAM binding site; other site 1201010003373 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1201010003374 Protein phosphatase 2C; Region: PP2C; pfam00481 1201010003375 active site 1201010003376 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1201010003377 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1201010003378 active site 1201010003379 ATP binding site [chemical binding]; other site 1201010003380 substrate binding site [chemical binding]; other site 1201010003381 activation loop (A-loop); other site 1201010003382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1201010003383 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1201010003384 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1201010003385 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1201010003386 Predicted GTPases [General function prediction only]; Region: COG1162 1201010003387 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1201010003388 RNA binding site [nucleotide binding]; other site 1201010003389 homodimer interface [polypeptide binding]; other site 1201010003390 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1201010003391 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1201010003392 GTP/Mg2+ binding site [chemical binding]; other site 1201010003393 G4 box; other site 1201010003394 G5 box; other site 1201010003395 G1 box; other site 1201010003396 Switch I region; other site 1201010003397 G2 box; other site 1201010003398 G3 box; other site 1201010003399 Switch II region; other site 1201010003400 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1201010003401 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1201010003402 substrate binding site [chemical binding]; other site 1201010003403 hexamer interface [polypeptide binding]; other site 1201010003404 metal binding site [ion binding]; metal-binding site 1201010003405 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1201010003406 Thiamine pyrophosphokinase; Region: TPK; cd07995 1201010003407 active site 1201010003408 dimerization interface [polypeptide binding]; other site 1201010003409 thiamine binding site [chemical binding]; other site 1201010003410 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1201010003411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1201010003412 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1201010003413 DAK2 domain; Region: Dak2; pfam02734 1201010003414 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1201010003415 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1201010003416 generic binding surface II; other site 1201010003417 ssDNA binding site; other site 1201010003418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010003419 ATP binding site [chemical binding]; other site 1201010003420 putative Mg++ binding site [ion binding]; other site 1201010003421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1201010003422 nucleotide binding region [chemical binding]; other site 1201010003423 ATP-binding site [chemical binding]; other site 1201010003424 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1201010003425 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1201010003426 active site 2 [active] 1201010003427 active site 1 [active] 1201010003428 putative phosphate acyltransferase; Provisional; Region: PRK05331 1201010003429 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1201010003430 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1201010003431 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1201010003432 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1201010003433 NAD(P) binding site [chemical binding]; other site 1201010003434 homotetramer interface [polypeptide binding]; other site 1201010003435 homodimer interface [polypeptide binding]; other site 1201010003436 active site 1201010003437 acyl carrier protein; Provisional; Region: acpP; PRK00982 1201010003438 ribonuclease III; Reviewed; Region: rnc; PRK00102 1201010003439 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1201010003440 dimerization interface [polypeptide binding]; other site 1201010003441 active site 1201010003442 metal binding site [ion binding]; metal-binding site 1201010003443 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1201010003444 dsRNA binding site [nucleotide binding]; other site 1201010003445 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1201010003446 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1201010003447 Walker A/P-loop; other site 1201010003448 ATP binding site [chemical binding]; other site 1201010003449 Q-loop/lid; other site 1201010003450 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1201010003451 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1201010003452 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1201010003453 ABC transporter signature motif; other site 1201010003454 Walker B; other site 1201010003455 D-loop; other site 1201010003456 H-loop/switch region; other site 1201010003457 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1201010003458 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1201010003459 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1201010003460 P loop; other site 1201010003461 GTP binding site [chemical binding]; other site 1201010003462 putative DNA-binding protein; Validated; Region: PRK00118 1201010003463 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1201010003464 signal recognition particle protein; Provisional; Region: PRK10867 1201010003465 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1201010003466 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1201010003467 P loop; other site 1201010003468 GTP binding site [chemical binding]; other site 1201010003469 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1201010003470 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1201010003471 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1201010003472 RimM N-terminal domain; Region: RimM; pfam01782 1201010003473 PRC-barrel domain; Region: PRC; pfam05239 1201010003474 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1201010003475 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1201010003476 Predicted membrane protein [Function unknown]; Region: COG4485 1201010003477 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1201010003478 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1201010003479 GTP/Mg2+ binding site [chemical binding]; other site 1201010003480 G4 box; other site 1201010003481 G5 box; other site 1201010003482 G1 box; other site 1201010003483 Switch I region; other site 1201010003484 G2 box; other site 1201010003485 G3 box; other site 1201010003486 Switch II region; other site 1201010003487 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1201010003488 RNA/DNA hybrid binding site [nucleotide binding]; other site 1201010003489 active site 1201010003490 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1201010003491 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1201010003492 CoA-ligase; Region: Ligase_CoA; pfam00549 1201010003493 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1201010003494 CoA binding domain; Region: CoA_binding; pfam02629 1201010003495 CoA-ligase; Region: Ligase_CoA; pfam00549 1201010003496 FemAB family; Region: FemAB; pfam02388 1201010003497 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1201010003498 DNA protecting protein DprA; Region: dprA; TIGR00732 1201010003499 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1201010003500 DNA topoisomerase I; Validated; Region: PRK05582 1201010003501 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1201010003502 active site 1201010003503 interdomain interaction site; other site 1201010003504 putative metal-binding site [ion binding]; other site 1201010003505 nucleotide binding site [chemical binding]; other site 1201010003506 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1201010003507 domain I; other site 1201010003508 DNA binding groove [nucleotide binding] 1201010003509 phosphate binding site [ion binding]; other site 1201010003510 domain II; other site 1201010003511 domain III; other site 1201010003512 nucleotide binding site [chemical binding]; other site 1201010003513 catalytic site [active] 1201010003514 domain IV; other site 1201010003515 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1201010003516 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1201010003517 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1201010003518 Glucose inhibited division protein A; Region: GIDA; pfam01134 1201010003519 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1201010003520 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1201010003521 active site 1201010003522 DNA binding site [nucleotide binding] 1201010003523 Int/Topo IB signature motif; other site 1201010003524 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1201010003525 active site 1201010003526 HslU subunit interaction site [polypeptide binding]; other site 1201010003527 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1201010003528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010003529 Walker A motif; other site 1201010003530 ATP binding site [chemical binding]; other site 1201010003531 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1201010003532 Walker B motif; other site 1201010003533 arginine finger; other site 1201010003534 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1201010003535 transcriptional repressor CodY; Validated; Region: PRK04158 1201010003536 CodY GAF-like domain; Region: CodY; pfam06018 1201010003537 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1201010003538 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1201010003539 rRNA interaction site [nucleotide binding]; other site 1201010003540 S8 interaction site; other site 1201010003541 putative laminin-1 binding site; other site 1201010003542 elongation factor Ts; Provisional; Region: tsf; PRK09377 1201010003543 UBA/TS-N domain; Region: UBA; pfam00627 1201010003544 Elongation factor TS; Region: EF_TS; pfam00889 1201010003545 Elongation factor TS; Region: EF_TS; pfam00889 1201010003546 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1201010003547 putative nucleotide binding site [chemical binding]; other site 1201010003548 uridine monophosphate binding site [chemical binding]; other site 1201010003549 homohexameric interface [polypeptide binding]; other site 1201010003550 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1201010003551 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1201010003552 hinge region; other site 1201010003553 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1201010003554 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1201010003555 catalytic residue [active] 1201010003556 putative FPP diphosphate binding site; other site 1201010003557 putative FPP binding hydrophobic cleft; other site 1201010003558 dimer interface [polypeptide binding]; other site 1201010003559 putative IPP diphosphate binding site; other site 1201010003560 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1201010003561 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1201010003562 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1201010003563 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1201010003564 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1201010003565 protein binding site [polypeptide binding]; other site 1201010003566 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1201010003567 putative substrate binding region [chemical binding]; other site 1201010003568 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1201010003569 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1201010003570 dimer interface [polypeptide binding]; other site 1201010003571 motif 1; other site 1201010003572 active site 1201010003573 motif 2; other site 1201010003574 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1201010003575 putative deacylase active site [active] 1201010003576 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1201010003577 active site 1201010003578 motif 3; other site 1201010003579 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1201010003580 anticodon binding site; other site 1201010003581 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1201010003582 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1201010003583 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1201010003584 generic binding surface II; other site 1201010003585 generic binding surface I; other site 1201010003586 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1201010003587 active site 1201010003588 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1201010003589 active site 1201010003590 catalytic site [active] 1201010003591 substrate binding site [chemical binding]; other site 1201010003592 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1201010003593 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1201010003594 Sm and related proteins; Region: Sm_like; cl00259 1201010003595 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1201010003596 putative oligomer interface [polypeptide binding]; other site 1201010003597 putative RNA binding site [nucleotide binding]; other site 1201010003598 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1201010003599 NusA N-terminal domain; Region: NusA_N; pfam08529 1201010003600 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1201010003601 RNA binding site [nucleotide binding]; other site 1201010003602 homodimer interface [polypeptide binding]; other site 1201010003603 NusA-like KH domain; Region: KH_5; pfam13184 1201010003604 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1201010003605 G-X-X-G motif; other site 1201010003606 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1201010003607 putative RNA binding cleft [nucleotide binding]; other site 1201010003608 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1201010003609 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1201010003610 translation initiation factor IF-2; Region: IF-2; TIGR00487 1201010003611 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1201010003612 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1201010003613 G1 box; other site 1201010003614 putative GEF interaction site [polypeptide binding]; other site 1201010003615 GTP/Mg2+ binding site [chemical binding]; other site 1201010003616 Switch I region; other site 1201010003617 G2 box; other site 1201010003618 G3 box; other site 1201010003619 Switch II region; other site 1201010003620 G4 box; other site 1201010003621 G5 box; other site 1201010003622 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1201010003623 Translation-initiation factor 2; Region: IF-2; pfam11987 1201010003624 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1201010003625 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1201010003626 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1201010003627 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1201010003628 RNA binding site [nucleotide binding]; other site 1201010003629 active site 1201010003630 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1201010003631 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1201010003632 active site 1201010003633 Riboflavin kinase; Region: Flavokinase; smart00904 1201010003634 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1201010003635 16S/18S rRNA binding site [nucleotide binding]; other site 1201010003636 S13e-L30e interaction site [polypeptide binding]; other site 1201010003637 25S rRNA binding site [nucleotide binding]; other site 1201010003638 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1201010003639 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1201010003640 RNase E interface [polypeptide binding]; other site 1201010003641 trimer interface [polypeptide binding]; other site 1201010003642 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1201010003643 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1201010003644 RNase E interface [polypeptide binding]; other site 1201010003645 trimer interface [polypeptide binding]; other site 1201010003646 active site 1201010003647 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1201010003648 putative nucleic acid binding region [nucleotide binding]; other site 1201010003649 G-X-X-G motif; other site 1201010003650 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1201010003651 RNA binding site [nucleotide binding]; other site 1201010003652 domain interface; other site 1201010003653 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1201010003654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1201010003655 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1201010003656 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1201010003657 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1201010003658 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1201010003659 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1201010003660 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1201010003661 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1201010003662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1201010003663 DNA-binding site [nucleotide binding]; DNA binding site 1201010003664 UTRA domain; Region: UTRA; pfam07702 1201010003665 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1201010003666 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1201010003667 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1201010003668 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1201010003669 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1201010003670 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1201010003671 classical (c) SDRs; Region: SDR_c; cd05233 1201010003672 NAD(P) binding site [chemical binding]; other site 1201010003673 active site 1201010003674 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1201010003675 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1201010003676 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1201010003677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010003678 non-specific DNA binding site [nucleotide binding]; other site 1201010003679 salt bridge; other site 1201010003680 sequence-specific DNA binding site [nucleotide binding]; other site 1201010003681 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1201010003682 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1201010003683 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1201010003684 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1201010003685 putative MPT binding site; other site 1201010003686 recombinase A; Provisional; Region: recA; PRK09354 1201010003687 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1201010003688 hexamer interface [polypeptide binding]; other site 1201010003689 Walker A motif; other site 1201010003690 ATP binding site [chemical binding]; other site 1201010003691 Walker B motif; other site 1201010003692 phosphodiesterase; Provisional; Region: PRK12704 1201010003693 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1201010003694 Zn2+ binding site [ion binding]; other site 1201010003695 Mg2+ binding site [ion binding]; other site 1201010003696 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1201010003697 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1201010003698 putative active site [active] 1201010003699 metal binding site [ion binding]; metal-binding site 1201010003700 homodimer binding site [polypeptide binding]; other site 1201010003701 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1201010003702 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1201010003703 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1201010003704 dimer interface [polypeptide binding]; other site 1201010003705 PYR/PP interface [polypeptide binding]; other site 1201010003706 TPP binding site [chemical binding]; other site 1201010003707 substrate binding site [chemical binding]; other site 1201010003708 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1201010003709 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1201010003710 TPP-binding site [chemical binding]; other site 1201010003711 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1201010003712 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1201010003713 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1201010003714 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1201010003715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010003716 FeS/SAM binding site; other site 1201010003717 TRAM domain; Region: TRAM; pfam01938 1201010003718 Predicted membrane protein [Function unknown]; Region: COG4550 1201010003719 Predicted membrane protein [Function unknown]; Region: COG4732 1201010003720 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1201010003721 MutS domain I; Region: MutS_I; pfam01624 1201010003722 MutS domain II; Region: MutS_II; pfam05188 1201010003723 MutS domain III; Region: MutS_III; pfam05192 1201010003724 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1201010003725 Walker A/P-loop; other site 1201010003726 ATP binding site [chemical binding]; other site 1201010003727 Q-loop/lid; other site 1201010003728 ABC transporter signature motif; other site 1201010003729 Walker B; other site 1201010003730 D-loop; other site 1201010003731 H-loop/switch region; other site 1201010003732 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1201010003733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010003734 ATP binding site [chemical binding]; other site 1201010003735 Mg2+ binding site [ion binding]; other site 1201010003736 G-X-G motif; other site 1201010003737 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1201010003738 ATP binding site [chemical binding]; other site 1201010003739 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1201010003740 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 1201010003741 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1201010003742 amphipathic channel; other site 1201010003743 Asn-Pro-Ala signature motifs; other site 1201010003744 glycerol kinase; Provisional; Region: glpK; PRK00047 1201010003745 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1201010003746 N- and C-terminal domain interface [polypeptide binding]; other site 1201010003747 active site 1201010003748 MgATP binding site [chemical binding]; other site 1201010003749 catalytic site [active] 1201010003750 metal binding site [ion binding]; metal-binding site 1201010003751 glycerol binding site [chemical binding]; other site 1201010003752 homotetramer interface [polypeptide binding]; other site 1201010003753 homodimer interface [polypeptide binding]; other site 1201010003754 FBP binding site [chemical binding]; other site 1201010003755 protein IIAGlc interface [polypeptide binding]; other site 1201010003756 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1201010003757 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1201010003758 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1201010003759 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 1201010003760 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1201010003761 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1201010003762 bacterial Hfq-like; Region: Hfq; cd01716 1201010003763 hexamer interface [polypeptide binding]; other site 1201010003764 Sm1 motif; other site 1201010003765 RNA binding site [nucleotide binding]; other site 1201010003766 Sm2 motif; other site 1201010003767 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1201010003768 catalytic residues [active] 1201010003769 dimer interface [polypeptide binding]; other site 1201010003770 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1201010003771 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1201010003772 HflX GTPase family; Region: HflX; cd01878 1201010003773 G1 box; other site 1201010003774 GTP/Mg2+ binding site [chemical binding]; other site 1201010003775 Switch I region; other site 1201010003776 G2 box; other site 1201010003777 G3 box; other site 1201010003778 Switch II region; other site 1201010003779 G4 box; other site 1201010003780 G5 box; other site 1201010003781 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1201010003782 Aluminium resistance protein; Region: Alum_res; pfam06838 1201010003783 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1201010003784 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1201010003785 DNA binding residues [nucleotide binding] 1201010003786 putative dimer interface [polypeptide binding]; other site 1201010003787 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1201010003788 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1201010003789 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1201010003790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1201010003791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1201010003792 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1201010003793 Sm and related proteins; Region: Sm_like; cl00259 1201010003794 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1201010003795 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1201010003796 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1201010003797 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1201010003798 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1201010003799 catalytic residue [active] 1201010003800 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1201010003801 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1201010003802 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1201010003803 putative active site [active] 1201010003804 catalytic site [active] 1201010003805 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1201010003806 putative active site [active] 1201010003807 catalytic site [active] 1201010003808 Staphylococcal nuclease homologues; Region: SNc; smart00318 1201010003809 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1201010003810 Catalytic site; other site 1201010003811 AAA domain; Region: AAA_11; pfam13086 1201010003812 aspartate kinase; Reviewed; Region: PRK09034 1201010003813 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1201010003814 putative catalytic residues [active] 1201010003815 putative nucleotide binding site [chemical binding]; other site 1201010003816 putative aspartate binding site [chemical binding]; other site 1201010003817 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1201010003818 allosteric regulatory residue; other site 1201010003819 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1201010003820 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1201010003821 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1201010003822 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1201010003823 threonine synthase; Reviewed; Region: PRK06721 1201010003824 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1201010003825 homodimer interface [polypeptide binding]; other site 1201010003826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010003827 catalytic residue [active] 1201010003828 homoserine kinase; Provisional; Region: PRK01212 1201010003829 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1201010003830 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1201010003831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010003832 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1201010003833 active site 1201010003834 motif I; other site 1201010003835 motif II; other site 1201010003836 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1201010003837 lysine transporter; Provisional; Region: PRK10836 1201010003838 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1201010003839 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1201010003840 tetramer interface [polypeptide binding]; other site 1201010003841 heme binding pocket [chemical binding]; other site 1201010003842 NADPH binding site [chemical binding]; other site 1201010003843 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1201010003844 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1201010003845 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1201010003846 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1201010003847 active site 1201010003848 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1201010003849 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1201010003850 LexA repressor; Validated; Region: PRK00215 1201010003851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1201010003852 putative DNA binding site [nucleotide binding]; other site 1201010003853 putative Zn2+ binding site [ion binding]; other site 1201010003854 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1201010003855 Catalytic site [active] 1201010003856 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1201010003857 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1201010003858 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1201010003859 TPP-binding site [chemical binding]; other site 1201010003860 dimer interface [polypeptide binding]; other site 1201010003861 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1201010003862 PYR/PP interface [polypeptide binding]; other site 1201010003863 dimer interface [polypeptide binding]; other site 1201010003864 TPP binding site [chemical binding]; other site 1201010003865 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1201010003866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1201010003867 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1201010003868 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1201010003869 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1201010003870 active site 1201010003871 metal binding site [ion binding]; metal-binding site 1201010003872 DNA binding site [nucleotide binding] 1201010003873 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1201010003874 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1201010003875 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1201010003876 Walker A/P-loop; other site 1201010003877 ATP binding site [chemical binding]; other site 1201010003878 Q-loop/lid; other site 1201010003879 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1201010003880 ABC transporter signature motif; other site 1201010003881 Walker B; other site 1201010003882 D-loop; other site 1201010003883 H-loop/switch region; other site 1201010003884 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1201010003885 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1201010003886 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1201010003887 aconitate hydratase; Validated; Region: PRK09277 1201010003888 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1201010003889 substrate binding site [chemical binding]; other site 1201010003890 ligand binding site [chemical binding]; other site 1201010003891 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1201010003892 substrate binding site [chemical binding]; other site 1201010003893 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1201010003894 active site 1201010003895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1201010003896 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1201010003897 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1201010003898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010003899 ATP binding site [chemical binding]; other site 1201010003900 Mg2+ binding site [ion binding]; other site 1201010003901 G-X-G motif; other site 1201010003902 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1201010003903 anchoring element; other site 1201010003904 dimer interface [polypeptide binding]; other site 1201010003905 ATP binding site [chemical binding]; other site 1201010003906 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1201010003907 active site 1201010003908 putative metal-binding site [ion binding]; other site 1201010003909 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1201010003910 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1201010003911 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1201010003912 CAP-like domain; other site 1201010003913 active site 1201010003914 primary dimer interface [polypeptide binding]; other site 1201010003915 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1201010003916 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1201010003917 amino acid carrier protein; Region: agcS; TIGR00835 1201010003918 CAT RNA binding domain; Region: CAT_RBD; smart01061 1201010003919 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1201010003920 PRD domain; Region: PRD; pfam00874 1201010003921 PRD domain; Region: PRD; pfam00874 1201010003922 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1201010003923 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1201010003924 Predicted integral membrane protein [Function unknown]; Region: COG0392 1201010003925 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1201010003926 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1201010003927 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1201010003928 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1201010003929 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1201010003930 active site 1 [active] 1201010003931 dimer interface [polypeptide binding]; other site 1201010003932 hexamer interface [polypeptide binding]; other site 1201010003933 active site 2 [active] 1201010003934 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1201010003935 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1201010003936 active site 1201010003937 DNA binding site [nucleotide binding] 1201010003938 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1201010003939 prephenate dehydrogenase; Validated; Region: PRK06545 1201010003940 prephenate dehydrogenase; Validated; Region: PRK08507 1201010003941 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1201010003942 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1201010003943 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1201010003944 putative oligomer interface [polypeptide binding]; other site 1201010003945 putative active site [active] 1201010003946 metal binding site [ion binding]; metal-binding site 1201010003947 anthranilate synthase component I; Provisional; Region: PRK13567 1201010003948 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1201010003949 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1201010003950 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1201010003951 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1201010003952 glutamine binding [chemical binding]; other site 1201010003953 catalytic triad [active] 1201010003954 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1201010003955 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1201010003956 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1201010003957 active site 1201010003958 ribulose/triose binding site [chemical binding]; other site 1201010003959 phosphate binding site [ion binding]; other site 1201010003960 substrate (anthranilate) binding pocket [chemical binding]; other site 1201010003961 product (indole) binding pocket [chemical binding]; other site 1201010003962 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1201010003963 active site 1201010003964 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1201010003965 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1201010003966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010003967 catalytic residue [active] 1201010003968 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1201010003969 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1201010003970 substrate binding site [chemical binding]; other site 1201010003971 active site 1201010003972 catalytic residues [active] 1201010003973 heterodimer interface [polypeptide binding]; other site 1201010003974 FemAB family; Region: FemAB; pfam02388 1201010003975 FlxA-like protein; Region: FlxA; pfam14282 1201010003976 FemAB family; Region: FemAB; pfam02388 1201010003977 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1201010003978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010003979 active site 1201010003980 motif I; other site 1201010003981 motif II; other site 1201010003982 SWIM zinc finger; Region: SWIM; pfam04434 1201010003983 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1201010003984 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010003985 Walker A/P-loop; other site 1201010003986 ATP binding site [chemical binding]; other site 1201010003987 Q-loop/lid; other site 1201010003988 ABC transporter signature motif; other site 1201010003989 Walker B; other site 1201010003990 D-loop; other site 1201010003991 H-loop/switch region; other site 1201010003992 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010003993 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1201010003994 Walker A/P-loop; other site 1201010003995 ATP binding site [chemical binding]; other site 1201010003996 Q-loop/lid; other site 1201010003997 ABC transporter signature motif; other site 1201010003998 Walker B; other site 1201010003999 D-loop; other site 1201010004000 H-loop/switch region; other site 1201010004001 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1201010004002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010004003 dimer interface [polypeptide binding]; other site 1201010004004 conserved gate region; other site 1201010004005 putative PBP binding loops; other site 1201010004006 ABC-ATPase subunit interface; other site 1201010004007 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1201010004008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010004009 dimer interface [polypeptide binding]; other site 1201010004010 conserved gate region; other site 1201010004011 putative PBP binding loops; other site 1201010004012 ABC-ATPase subunit interface; other site 1201010004013 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1201010004014 oligoendopeptidase F; Region: pepF; TIGR00181 1201010004015 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1201010004016 active site 1201010004017 Zn binding site [ion binding]; other site 1201010004018 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1201010004019 PhoU domain; Region: PhoU; pfam01895 1201010004020 PhoU domain; Region: PhoU; pfam01895 1201010004021 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1201010004022 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1201010004023 Walker A/P-loop; other site 1201010004024 ATP binding site [chemical binding]; other site 1201010004025 Q-loop/lid; other site 1201010004026 ABC transporter signature motif; other site 1201010004027 Walker B; other site 1201010004028 D-loop; other site 1201010004029 H-loop/switch region; other site 1201010004030 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1201010004031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010004032 dimer interface [polypeptide binding]; other site 1201010004033 conserved gate region; other site 1201010004034 putative PBP binding loops; other site 1201010004035 ABC-ATPase subunit interface; other site 1201010004036 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1201010004037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010004038 dimer interface [polypeptide binding]; other site 1201010004039 conserved gate region; other site 1201010004040 ABC-ATPase subunit interface; other site 1201010004041 phosphate binding protein; Region: ptsS_2; TIGR02136 1201010004042 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1201010004043 S1 domain; Region: S1_2; pfam13509 1201010004044 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1201010004045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1201010004046 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1201010004047 ABC transporter; Region: ABC_tran_2; pfam12848 1201010004048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1201010004049 aspartate kinase; Reviewed; Region: PRK06635 1201010004050 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1201010004051 putative nucleotide binding site [chemical binding]; other site 1201010004052 putative catalytic residues [active] 1201010004053 putative Mg ion binding site [ion binding]; other site 1201010004054 putative aspartate binding site [chemical binding]; other site 1201010004055 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1201010004056 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1201010004057 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1201010004058 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1201010004059 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1201010004060 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1201010004061 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1201010004062 dimer interface [polypeptide binding]; other site 1201010004063 active site 1201010004064 catalytic residue [active] 1201010004065 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1201010004066 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1201010004067 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1201010004068 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1201010004069 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1201010004070 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1201010004071 active site 1201010004072 trimer interface [polypeptide binding]; other site 1201010004073 substrate binding site [chemical binding]; other site 1201010004074 CoA binding site [chemical binding]; other site 1201010004075 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1201010004076 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1201010004077 metal binding site [ion binding]; metal-binding site 1201010004078 dimer interface [polypeptide binding]; other site 1201010004079 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1201010004080 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1201010004081 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1201010004082 catalytic residue [active] 1201010004083 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1201010004084 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1201010004085 active site 1201010004086 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1201010004087 substrate binding site [chemical binding]; other site 1201010004088 catalytic residues [active] 1201010004089 dimer interface [polypeptide binding]; other site 1201010004090 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1201010004091 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1201010004092 DNA-binding site [nucleotide binding]; DNA binding site 1201010004093 RNA-binding motif; other site 1201010004094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1201010004095 acylphosphatase; Provisional; Region: PRK14431 1201010004096 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1201010004097 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1201010004098 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1201010004099 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1201010004100 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1201010004101 metal ion-dependent adhesion site (MIDAS); other site 1201010004102 MoxR-like ATPases [General function prediction only]; Region: COG0714 1201010004103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010004104 Walker A motif; other site 1201010004105 ATP binding site [chemical binding]; other site 1201010004106 Walker B motif; other site 1201010004107 arginine finger; other site 1201010004108 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1201010004109 active site 1201010004110 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1201010004111 active site 1201010004112 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1201010004113 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1201010004114 E3 interaction surface; other site 1201010004115 lipoyl attachment site [posttranslational modification]; other site 1201010004116 e3 binding domain; Region: E3_binding; pfam02817 1201010004117 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1201010004118 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1201010004119 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1201010004120 TPP-binding site [chemical binding]; other site 1201010004121 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1201010004122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1201010004123 HAMP domain; Region: HAMP; pfam00672 1201010004124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1201010004125 dimer interface [polypeptide binding]; other site 1201010004126 phosphorylation site [posttranslational modification] 1201010004127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010004128 ATP binding site [chemical binding]; other site 1201010004129 Mg2+ binding site [ion binding]; other site 1201010004130 G-X-G motif; other site 1201010004131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1201010004132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010004133 active site 1201010004134 phosphorylation site [posttranslational modification] 1201010004135 intermolecular recognition site; other site 1201010004136 dimerization interface [polypeptide binding]; other site 1201010004137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1201010004138 DNA binding site [nucleotide binding] 1201010004139 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1201010004140 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1201010004141 active site 1201010004142 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1201010004143 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1201010004144 active site 1201010004145 homodimer interface [polypeptide binding]; other site 1201010004146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010004147 Coenzyme A binding pocket [chemical binding]; other site 1201010004148 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1201010004149 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1201010004150 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1201010004151 protein binding site [polypeptide binding]; other site 1201010004152 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1201010004153 Catalytic dyad [active] 1201010004154 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1201010004155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 1201010004156 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1201010004157 HPr interaction site; other site 1201010004158 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1201010004159 active site 1201010004160 phosphorylation site [posttranslational modification] 1201010004161 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1201010004162 SelR domain; Region: SelR; pfam01641 1201010004163 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1201010004164 EDD domain protein, DegV family; Region: DegV; TIGR00762 1201010004165 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1201010004166 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1201010004167 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1201010004168 folate binding site [chemical binding]; other site 1201010004169 NADP+ binding site [chemical binding]; other site 1201010004170 thymidylate synthase; Region: thym_sym; TIGR03284 1201010004171 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1201010004172 dimerization interface [polypeptide binding]; other site 1201010004173 active site 1201010004174 Disulphide isomerase; Region: Disulph_isomer; cl05813 1201010004175 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1201010004176 Virulence factor; Region: Virulence_fact; pfam13769 1201010004177 HEAT repeats; Region: HEAT_2; pfam13646 1201010004178 HEAT repeat; Region: HEAT; pfam02985 1201010004179 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1201010004180 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1201010004181 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1201010004182 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1201010004183 RNA/DNA hybrid binding site [nucleotide binding]; other site 1201010004184 active site 1201010004185 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1201010004186 Amino acid permease; Region: AA_permease_2; pfam13520 1201010004187 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1201010004188 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1201010004189 tetramer interface [polypeptide binding]; other site 1201010004190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010004191 catalytic residue [active] 1201010004192 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1201010004193 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1201010004194 hexamer interface [polypeptide binding]; other site 1201010004195 ligand binding site [chemical binding]; other site 1201010004196 putative active site [active] 1201010004197 NAD(P) binding site [chemical binding]; other site 1201010004198 5'-3' exonuclease; Region: 53EXOc; smart00475 1201010004199 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1201010004200 active site 1201010004201 metal binding site 1 [ion binding]; metal-binding site 1201010004202 putative 5' ssDNA interaction site; other site 1201010004203 metal binding site 3; metal-binding site 1201010004204 metal binding site 2 [ion binding]; metal-binding site 1201010004205 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1201010004206 putative DNA binding site [nucleotide binding]; other site 1201010004207 putative metal binding site [ion binding]; other site 1201010004208 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1201010004209 Dynamin family; Region: Dynamin_N; pfam00350 1201010004210 G1 box; other site 1201010004211 GTP/Mg2+ binding site [chemical binding]; other site 1201010004212 G2 box; other site 1201010004213 Switch I region; other site 1201010004214 G3 box; other site 1201010004215 Switch II region; other site 1201010004216 G4 box; other site 1201010004217 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1201010004218 Dynamin family; Region: Dynamin_N; pfam00350 1201010004219 G1 box; other site 1201010004220 GTP/Mg2+ binding site [chemical binding]; other site 1201010004221 G2 box; other site 1201010004222 Switch I region; other site 1201010004223 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1201010004224 G3 box; other site 1201010004225 Switch II region; other site 1201010004226 GTP/Mg2+ binding site [chemical binding]; other site 1201010004227 G4 box; other site 1201010004228 G5 box; other site 1201010004229 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1201010004230 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1201010004231 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1201010004232 Cobalt transport protein component CbiN; Region: CbiN; cl00842 1201010004233 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1201010004234 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1201010004235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1201010004236 cell division protein GpsB; Provisional; Region: PRK14127 1201010004237 DivIVA domain; Region: DivI1A_domain; TIGR03544 1201010004238 hypothetical protein; Provisional; Region: PRK13660 1201010004239 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1201010004240 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1201010004241 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1201010004242 Transglycosylase; Region: Transgly; pfam00912 1201010004243 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1201010004244 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1201010004245 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1201010004246 minor groove reading motif; other site 1201010004247 helix-hairpin-helix signature motif; other site 1201010004248 substrate binding pocket [chemical binding]; other site 1201010004249 active site 1201010004250 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1201010004251 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1201010004252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1201010004253 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1201010004254 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1201010004255 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1201010004256 putative dimer interface [polypeptide binding]; other site 1201010004257 putative anticodon binding site; other site 1201010004258 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1201010004259 homodimer interface [polypeptide binding]; other site 1201010004260 motif 1; other site 1201010004261 motif 2; other site 1201010004262 active site 1201010004263 motif 3; other site 1201010004264 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1201010004265 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1201010004266 active site 1201010004267 catalytic site [active] 1201010004268 substrate binding site [chemical binding]; other site 1201010004269 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1201010004270 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1201010004271 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1201010004272 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1201010004273 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1201010004274 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1201010004275 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1201010004276 active site 1201010004277 NTP binding site [chemical binding]; other site 1201010004278 metal binding triad [ion binding]; metal-binding site 1201010004279 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1201010004280 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1201010004281 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1201010004282 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1201010004283 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1201010004284 homodimer interface [polypeptide binding]; other site 1201010004285 metal binding site [ion binding]; metal-binding site 1201010004286 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1201010004287 Predicted membrane protein [Function unknown]; Region: COG4347 1201010004288 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1201010004289 UPF0302 domain; Region: UPF0302; pfam08864 1201010004290 A short protein domain of unknown function; Region: IDEAL; smart00914 1201010004291 TPR repeat; Region: TPR_11; pfam13414 1201010004292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1201010004293 binding surface 1201010004294 TPR motif; other site 1201010004295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1201010004296 TPR motif; other site 1201010004297 binding surface 1201010004298 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1201010004299 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1201010004300 hinge; other site 1201010004301 active site 1201010004302 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1201010004303 active site 1201010004304 NAD binding site [chemical binding]; other site 1201010004305 metal binding site [ion binding]; metal-binding site 1201010004306 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1201010004307 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1201010004308 Tetramer interface [polypeptide binding]; other site 1201010004309 active site 1201010004310 FMN-binding site [chemical binding]; other site 1201010004311 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1201010004312 active site 1201010004313 multimer interface [polypeptide binding]; other site 1201010004314 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1201010004315 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1201010004316 substrate binding pocket [chemical binding]; other site 1201010004317 chain length determination region; other site 1201010004318 substrate-Mg2+ binding site; other site 1201010004319 catalytic residues [active] 1201010004320 aspartate-rich region 1; other site 1201010004321 active site lid residues [active] 1201010004322 aspartate-rich region 2; other site 1201010004323 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1201010004324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010004325 S-adenosylmethionine binding site [chemical binding]; other site 1201010004326 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1201010004327 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1201010004328 IHF dimer interface [polypeptide binding]; other site 1201010004329 IHF - DNA interface [nucleotide binding]; other site 1201010004330 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1201010004331 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1201010004332 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1201010004333 GTP-binding protein Der; Reviewed; Region: PRK00093 1201010004334 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1201010004335 G1 box; other site 1201010004336 GTP/Mg2+ binding site [chemical binding]; other site 1201010004337 Switch I region; other site 1201010004338 G2 box; other site 1201010004339 Switch II region; other site 1201010004340 G3 box; other site 1201010004341 G4 box; other site 1201010004342 G5 box; other site 1201010004343 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1201010004344 G1 box; other site 1201010004345 GTP/Mg2+ binding site [chemical binding]; other site 1201010004346 Switch I region; other site 1201010004347 G2 box; other site 1201010004348 G3 box; other site 1201010004349 Switch II region; other site 1201010004350 G4 box; other site 1201010004351 G5 box; other site 1201010004352 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1201010004353 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1201010004354 RNA binding site [nucleotide binding]; other site 1201010004355 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1201010004356 RNA binding site [nucleotide binding]; other site 1201010004357 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1201010004358 RNA binding site [nucleotide binding]; other site 1201010004359 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1201010004360 RNA binding site [nucleotide binding]; other site 1201010004361 cytidylate kinase; Provisional; Region: cmk; PRK00023 1201010004362 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1201010004363 CMP-binding site; other site 1201010004364 The sites determining sugar specificity; other site 1201010004365 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1201010004366 active site 1201010004367 homotetramer interface [polypeptide binding]; other site 1201010004368 homodimer interface [polypeptide binding]; other site 1201010004369 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1201010004370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1201010004371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010004372 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1201010004373 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1201010004374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010004375 ATP binding site [chemical binding]; other site 1201010004376 putative Mg++ binding site [ion binding]; other site 1201010004377 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1201010004378 nucleotide binding region [chemical binding]; other site 1201010004379 ATP-binding site [chemical binding]; other site 1201010004380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1201010004381 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1201010004382 Predicted membrane protein [Function unknown]; Region: COG3601 1201010004383 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1201010004384 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1201010004385 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1201010004386 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1201010004387 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1201010004388 CHAP domain; Region: CHAP; pfam05257 1201010004389 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1201010004390 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1201010004391 active site 1201010004392 metal binding site [ion binding]; metal-binding site 1201010004393 Bacterial SH3 domain; Region: SH3_5; pfam08460 1201010004394 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1201010004395 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1201010004396 Ligand-gated ion channel; Region: Lig_chan; pfam00060 1201010004397 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1201010004398 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1201010004399 Phage tail protein; Region: Sipho_tail; cl17486 1201010004400 Phage tail protein; Region: Sipho_tail; cl17486 1201010004401 Phage-related minor tail protein [Function unknown]; Region: COG5280 1201010004402 Phage-related protein [Function unknown]; Region: COG5412 1201010004403 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 1201010004404 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1201010004405 Peptidase family M23; Region: Peptidase_M23; pfam01551 1201010004406 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1201010004407 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1201010004408 catalytic residue [active] 1201010004409 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1201010004410 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1201010004411 Translocation protein Sec62; Region: Sec62; cl02170 1201010004412 Phage capsid family; Region: Phage_capsid; pfam05065 1201010004413 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1201010004414 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1201010004415 oligomer interface [polypeptide binding]; other site 1201010004416 active site residues [active] 1201010004417 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1201010004418 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1201010004419 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1201010004420 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1201010004421 HNH endonuclease; Region: HNH; pfam01844 1201010004422 active site 1201010004423 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1201010004424 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1201010004425 Transcriptional activator RinB; Region: RinB; pfam06116 1201010004426 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1201010004427 dUTPase; Region: dUTPase_2; pfam08761 1201010004428 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1201010004429 active site 1201010004430 homodimer interface [polypeptide binding]; other site 1201010004431 metal binding site [ion binding]; metal-binding site 1201010004432 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1201010004433 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1201010004434 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1201010004435 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 1201010004436 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1201010004437 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 1201010004438 hypothetical protein; Validated; Region: PRK08116 1201010004439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010004440 Walker A motif; other site 1201010004441 ATP binding site [chemical binding]; other site 1201010004442 Walker B motif; other site 1201010004443 Helix-turn-helix domain; Region: HTH_36; pfam13730 1201010004444 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 1201010004445 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1201010004446 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1201010004447 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1201010004448 dimer interface [polypeptide binding]; other site 1201010004449 ssDNA binding site [nucleotide binding]; other site 1201010004450 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1201010004451 ERF superfamily; Region: ERF; pfam04404 1201010004452 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 1201010004453 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1201010004454 Homeodomain-like domain; Region: HTH_23; pfam13384 1201010004455 Phage anti-repressor protein [Transcription]; Region: COG3561 1201010004456 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1201010004457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010004458 salt bridge; other site 1201010004459 non-specific DNA binding site [nucleotide binding]; other site 1201010004460 sequence-specific DNA binding site [nucleotide binding]; other site 1201010004461 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1201010004462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010004463 non-specific DNA binding site [nucleotide binding]; other site 1201010004464 salt bridge; other site 1201010004465 sequence-specific DNA binding site [nucleotide binding]; other site 1201010004466 Predicted transcriptional regulator [Transcription]; Region: COG2932 1201010004467 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1201010004468 Catalytic site [active] 1201010004469 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1201010004470 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1201010004471 Int/Topo IB signature motif; other site 1201010004472 AAA domain; Region: AAA_13; pfam13166 1201010004473 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1201010004474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1201010004475 dimerization interface [polypeptide binding]; other site 1201010004476 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1201010004477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1201010004478 dimer interface [polypeptide binding]; other site 1201010004479 phosphorylation site [posttranslational modification] 1201010004480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010004481 ATP binding site [chemical binding]; other site 1201010004482 Mg2+ binding site [ion binding]; other site 1201010004483 G-X-G motif; other site 1201010004484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1201010004485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010004486 active site 1201010004487 phosphorylation site [posttranslational modification] 1201010004488 intermolecular recognition site; other site 1201010004489 dimerization interface [polypeptide binding]; other site 1201010004490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1201010004491 DNA binding site [nucleotide binding] 1201010004492 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1201010004493 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1201010004494 RNA binding surface [nucleotide binding]; other site 1201010004495 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1201010004496 active site 1201010004497 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1201010004498 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1201010004499 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1201010004500 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1201010004501 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1201010004502 active site 1201010004503 Int/Topo IB signature motif; other site 1201010004504 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1201010004505 metal binding site 2 [ion binding]; metal-binding site 1201010004506 putative DNA binding helix; other site 1201010004507 metal binding site 1 [ion binding]; metal-binding site 1201010004508 dimer interface [polypeptide binding]; other site 1201010004509 structural Zn2+ binding site [ion binding]; other site 1201010004510 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1201010004511 dimer interface [polypeptide binding]; other site 1201010004512 ADP-ribose binding site [chemical binding]; other site 1201010004513 active site 1201010004514 nudix motif; other site 1201010004515 metal binding site [ion binding]; metal-binding site 1201010004516 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1201010004517 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1201010004518 active site 1201010004519 catalytic tetrad [active] 1201010004520 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1201010004521 classical (c) SDRs; Region: SDR_c; cd05233 1201010004522 NAD(P) binding site [chemical binding]; other site 1201010004523 active site 1201010004524 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1201010004525 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1201010004526 ribonuclease Z; Region: RNase_Z; TIGR02651 1201010004527 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1201010004528 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1201010004529 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1201010004530 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1201010004531 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1201010004532 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1201010004533 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1201010004534 Ca binding site [ion binding]; other site 1201010004535 active site 1201010004536 catalytic site [active] 1201010004537 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1201010004538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1201010004539 DNA binding site [nucleotide binding] 1201010004540 domain linker motif; other site 1201010004541 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1201010004542 putative ligand binding site [chemical binding]; other site 1201010004543 putative dimerization interface [polypeptide binding]; other site 1201010004544 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1201010004545 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1201010004546 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1201010004547 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1201010004548 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1201010004549 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1201010004550 peptidase T-like protein; Region: PepT-like; TIGR01883 1201010004551 metal binding site [ion binding]; metal-binding site 1201010004552 putative dimer interface [polypeptide binding]; other site 1201010004553 Predicted membrane protein [Function unknown]; Region: COG4129 1201010004554 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1201010004555 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1201010004556 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1201010004557 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1201010004558 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1201010004559 E3 interaction surface; other site 1201010004560 lipoyl attachment site [posttranslational modification]; other site 1201010004561 e3 binding domain; Region: E3_binding; pfam02817 1201010004562 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1201010004563 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1201010004564 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1201010004565 alpha subunit interface [polypeptide binding]; other site 1201010004566 TPP binding site [chemical binding]; other site 1201010004567 heterodimer interface [polypeptide binding]; other site 1201010004568 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1201010004569 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1201010004570 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1201010004571 tetramer interface [polypeptide binding]; other site 1201010004572 TPP-binding site [chemical binding]; other site 1201010004573 heterodimer interface [polypeptide binding]; other site 1201010004574 phosphorylation loop region [posttranslational modification] 1201010004575 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1201010004576 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1201010004577 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010004578 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1201010004579 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1201010004580 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1201010004581 Walker A/P-loop; other site 1201010004582 ATP binding site [chemical binding]; other site 1201010004583 Q-loop/lid; other site 1201010004584 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1201010004585 ABC transporter signature motif; other site 1201010004586 Walker B; other site 1201010004587 D-loop; other site 1201010004588 H-loop/switch region; other site 1201010004589 arginine repressor; Provisional; Region: PRK04280 1201010004590 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1201010004591 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1201010004592 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1201010004593 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1201010004594 substrate binding pocket [chemical binding]; other site 1201010004595 chain length determination region; other site 1201010004596 substrate-Mg2+ binding site; other site 1201010004597 catalytic residues [active] 1201010004598 aspartate-rich region 1; other site 1201010004599 active site lid residues [active] 1201010004600 aspartate-rich region 2; other site 1201010004601 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1201010004602 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1201010004603 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1201010004604 generic binding surface II; other site 1201010004605 generic binding surface I; other site 1201010004606 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1201010004607 putative RNA binding site [nucleotide binding]; other site 1201010004608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1201010004609 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1201010004610 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1201010004611 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1201010004612 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1201010004613 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1201010004614 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1201010004615 carboxyltransferase (CT) interaction site; other site 1201010004616 biotinylation site [posttranslational modification]; other site 1201010004617 elongation factor P; Validated; Region: PRK00529 1201010004618 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1201010004619 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1201010004620 RNA binding site [nucleotide binding]; other site 1201010004621 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1201010004622 RNA binding site [nucleotide binding]; other site 1201010004623 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1201010004624 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1201010004625 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1201010004626 active site 1201010004627 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1201010004628 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1201010004629 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1201010004630 active site residue [active] 1201010004631 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1201010004632 tetramer interface [polypeptide binding]; other site 1201010004633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010004634 catalytic residue [active] 1201010004635 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1201010004636 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1201010004637 tetramer interface [polypeptide binding]; other site 1201010004638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010004639 catalytic residue [active] 1201010004640 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1201010004641 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1201010004642 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1201010004643 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1201010004644 ADP binding site [chemical binding]; other site 1201010004645 magnesium binding site [ion binding]; other site 1201010004646 putative shikimate binding site; other site 1201010004647 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1201010004648 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1201010004649 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1201010004650 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1201010004651 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1201010004652 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1201010004653 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1201010004654 Type II/IV secretion system protein; Region: T2SE; pfam00437 1201010004655 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1201010004656 Walker A motif; other site 1201010004657 ATP binding site [chemical binding]; other site 1201010004658 Walker B motif; other site 1201010004659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1201010004660 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1201010004661 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1201010004662 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1201010004663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1201010004664 Rhomboid family; Region: Rhomboid; pfam01694 1201010004665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1201010004666 binding surface 1201010004667 TPR motif; other site 1201010004668 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1201010004669 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1201010004670 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1201010004671 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1201010004672 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1201010004673 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1201010004674 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1201010004675 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1201010004676 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1201010004677 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1201010004678 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1201010004679 metal binding site 2 [ion binding]; metal-binding site 1201010004680 putative DNA binding helix; other site 1201010004681 metal binding site 1 [ion binding]; metal-binding site 1201010004682 dimer interface [polypeptide binding]; other site 1201010004683 structural Zn2+ binding site [ion binding]; other site 1201010004684 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1201010004685 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010004686 ABC-ATPase subunit interface; other site 1201010004687 dimer interface [polypeptide binding]; other site 1201010004688 putative PBP binding regions; other site 1201010004689 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1201010004690 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1201010004691 endonuclease IV; Provisional; Region: PRK01060 1201010004692 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1201010004693 AP (apurinic/apyrimidinic) site pocket; other site 1201010004694 DNA interaction; other site 1201010004695 Metal-binding active site; metal-binding site 1201010004696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1201010004697 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1201010004698 ATP binding site [chemical binding]; other site 1201010004699 putative Mg++ binding site [ion binding]; other site 1201010004700 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1201010004701 nucleotide binding region [chemical binding]; other site 1201010004702 ATP-binding site [chemical binding]; other site 1201010004703 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1201010004704 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1201010004705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1201010004706 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1201010004707 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1201010004708 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1201010004709 Family of unknown function (DUF633); Region: DUF633; pfam04816 1201010004710 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1201010004711 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1201010004712 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1201010004713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1201010004714 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1201010004715 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1201010004716 DNA binding residues [nucleotide binding] 1201010004717 DNA primase, catalytic core; Region: dnaG; TIGR01391 1201010004718 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1201010004719 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1201010004720 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1201010004721 active site 1201010004722 metal binding site [ion binding]; metal-binding site 1201010004723 interdomain interaction site; other site 1201010004724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1201010004725 HTH domain; Region: HTH_11; cl17392 1201010004726 FOG: CBS domain [General function prediction only]; Region: COG0517 1201010004727 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1201010004728 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1201010004729 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1201010004730 motif 1; other site 1201010004731 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1201010004732 active site 1201010004733 motif 2; other site 1201010004734 motif 3; other site 1201010004735 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1201010004736 anticodon binding site; other site 1201010004737 DNA repair protein RecO; Region: reco; TIGR00613 1201010004738 Recombination protein O N terminal; Region: RecO_N; pfam11967 1201010004739 Recombination protein O C terminal; Region: RecO_C; pfam02565 1201010004740 GTPase Era; Reviewed; Region: era; PRK00089 1201010004741 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1201010004742 G1 box; other site 1201010004743 GTP/Mg2+ binding site [chemical binding]; other site 1201010004744 Switch I region; other site 1201010004745 G2 box; other site 1201010004746 Switch II region; other site 1201010004747 G3 box; other site 1201010004748 G4 box; other site 1201010004749 G5 box; other site 1201010004750 KH domain; Region: KH_2; pfam07650 1201010004751 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1201010004752 active site 1201010004753 catalytic motif [active] 1201010004754 Zn binding site [ion binding]; other site 1201010004755 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1201010004756 metal-binding heat shock protein; Provisional; Region: PRK00016 1201010004757 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1201010004758 PhoH-like protein; Region: PhoH; pfam02562 1201010004759 hypothetical protein; Provisional; Region: PRK13665 1201010004760 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1201010004761 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1201010004762 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1201010004763 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1201010004764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010004765 FeS/SAM binding site; other site 1201010004766 TRAM domain; Region: TRAM; cl01282 1201010004767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1201010004768 RNA methyltransferase, RsmE family; Region: TIGR00046 1201010004769 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1201010004770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010004771 S-adenosylmethionine binding site [chemical binding]; other site 1201010004772 chaperone protein DnaJ; Provisional; Region: PRK14280 1201010004773 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1201010004774 HSP70 interaction site [polypeptide binding]; other site 1201010004775 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1201010004776 substrate binding site [polypeptide binding]; other site 1201010004777 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1201010004778 Zn binding sites [ion binding]; other site 1201010004779 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1201010004780 dimer interface [polypeptide binding]; other site 1201010004781 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1201010004782 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1201010004783 nucleotide binding site [chemical binding]; other site 1201010004784 NEF interaction site [polypeptide binding]; other site 1201010004785 SBD interface [polypeptide binding]; other site 1201010004786 heat shock protein GrpE; Provisional; Region: PRK14140 1201010004787 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1201010004788 dimer interface [polypeptide binding]; other site 1201010004789 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1201010004790 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1201010004791 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1201010004792 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 1201010004793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010004794 FeS/SAM binding site; other site 1201010004795 HemN C-terminal domain; Region: HemN_C; pfam06969 1201010004796 GTP-binding protein LepA; Provisional; Region: PRK05433 1201010004797 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1201010004798 G1 box; other site 1201010004799 putative GEF interaction site [polypeptide binding]; other site 1201010004800 GTP/Mg2+ binding site [chemical binding]; other site 1201010004801 Switch I region; other site 1201010004802 G2 box; other site 1201010004803 G3 box; other site 1201010004804 Switch II region; other site 1201010004805 G4 box; other site 1201010004806 G5 box; other site 1201010004807 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1201010004808 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1201010004809 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1201010004810 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1201010004811 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1201010004812 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1201010004813 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1201010004814 Competence protein; Region: Competence; pfam03772 1201010004815 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1201010004816 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1201010004817 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1201010004818 catalytic motif [active] 1201010004819 Zn binding site [ion binding]; other site 1201010004820 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1201010004821 Helix-hairpin-helix motif; Region: HHH; pfam00633 1201010004822 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1201010004823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010004824 S-adenosylmethionine binding site [chemical binding]; other site 1201010004825 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1201010004826 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1201010004827 Zn2+ binding site [ion binding]; other site 1201010004828 Mg2+ binding site [ion binding]; other site 1201010004829 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1201010004830 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1201010004831 active site 1201010004832 (T/H)XGH motif; other site 1201010004833 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1201010004834 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1201010004835 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1201010004836 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1201010004837 shikimate binding site; other site 1201010004838 NAD(P) binding site [chemical binding]; other site 1201010004839 GTPase YqeH; Provisional; Region: PRK13796 1201010004840 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1201010004841 GTP/Mg2+ binding site [chemical binding]; other site 1201010004842 G4 box; other site 1201010004843 G5 box; other site 1201010004844 G1 box; other site 1201010004845 Switch I region; other site 1201010004846 G2 box; other site 1201010004847 G3 box; other site 1201010004848 Switch II region; other site 1201010004849 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1201010004850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010004851 active site 1201010004852 motif I; other site 1201010004853 motif II; other site 1201010004854 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1201010004855 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1201010004856 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1201010004857 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1201010004858 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010004859 Fic family protein [Function unknown]; Region: COG3177 1201010004860 Fic/DOC family; Region: Fic; pfam02661 1201010004861 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1201010004862 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1201010004863 putative active site [active] 1201010004864 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1201010004865 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1201010004866 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1201010004867 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1201010004868 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1201010004869 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1201010004870 carboxyltransferase (CT) interaction site; other site 1201010004871 biotinylation site [posttranslational modification]; other site 1201010004872 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1201010004873 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1201010004874 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1201010004875 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1201010004876 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1201010004877 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1201010004878 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1201010004879 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1201010004880 Sugar specificity; other site 1201010004881 Pyrimidine base specificity; other site 1201010004882 ATP-binding site [chemical binding]; other site 1201010004883 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1201010004884 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1201010004885 Peptidase family U32; Region: Peptidase_U32; pfam01136 1201010004886 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1201010004887 Peptidase family U32; Region: Peptidase_U32; pfam01136 1201010004888 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1201010004889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010004890 S-adenosylmethionine binding site [chemical binding]; other site 1201010004891 hypothetical protein; Provisional; Region: PRK13678 1201010004892 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1201010004893 hypothetical protein; Provisional; Region: PRK05473 1201010004894 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1201010004895 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1201010004896 motif 1; other site 1201010004897 active site 1201010004898 motif 2; other site 1201010004899 motif 3; other site 1201010004900 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1201010004901 DHHA1 domain; Region: DHHA1; pfam02272 1201010004902 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1201010004903 AAA domain; Region: AAA_30; pfam13604 1201010004904 Family description; Region: UvrD_C_2; pfam13538 1201010004905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1201010004906 binding surface 1201010004907 TPR motif; other site 1201010004908 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1201010004909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1201010004910 binding surface 1201010004911 TPR motif; other site 1201010004912 TPR repeat; Region: TPR_11; pfam13414 1201010004913 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1201010004914 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1201010004915 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1201010004916 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1201010004917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1201010004918 catalytic residue [active] 1201010004919 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1201010004920 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1201010004921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1201010004922 Predicted transcriptional regulator [Transcription]; Region: COG1959 1201010004923 Transcriptional regulator; Region: Rrf2; pfam02082 1201010004924 recombination factor protein RarA; Reviewed; Region: PRK13342 1201010004925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010004926 Walker A motif; other site 1201010004927 ATP binding site [chemical binding]; other site 1201010004928 Walker B motif; other site 1201010004929 arginine finger; other site 1201010004930 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1201010004931 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1201010004932 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1201010004933 putative ATP binding site [chemical binding]; other site 1201010004934 putative substrate interface [chemical binding]; other site 1201010004935 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1201010004936 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1201010004937 dimer interface [polypeptide binding]; other site 1201010004938 anticodon binding site; other site 1201010004939 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1201010004940 homodimer interface [polypeptide binding]; other site 1201010004941 motif 1; other site 1201010004942 active site 1201010004943 motif 2; other site 1201010004944 GAD domain; Region: GAD; pfam02938 1201010004945 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1201010004946 motif 3; other site 1201010004947 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1201010004948 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1201010004949 dimer interface [polypeptide binding]; other site 1201010004950 motif 1; other site 1201010004951 active site 1201010004952 motif 2; other site 1201010004953 motif 3; other site 1201010004954 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1201010004955 anticodon binding site; other site 1201010004956 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1201010004957 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1201010004958 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1201010004959 active site 1201010004960 metal binding site [ion binding]; metal-binding site 1201010004961 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1201010004962 putative active site [active] 1201010004963 dimerization interface [polypeptide binding]; other site 1201010004964 putative tRNAtyr binding site [nucleotide binding]; other site 1201010004965 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1201010004966 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1201010004967 Zn2+ binding site [ion binding]; other site 1201010004968 Mg2+ binding site [ion binding]; other site 1201010004969 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1201010004970 synthetase active site [active] 1201010004971 NTP binding site [chemical binding]; other site 1201010004972 metal binding site [ion binding]; metal-binding site 1201010004973 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1201010004974 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1201010004975 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1201010004976 active site 1201010004977 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1201010004978 DHH family; Region: DHH; pfam01368 1201010004979 DHHA1 domain; Region: DHHA1; pfam02272 1201010004980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1201010004981 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1201010004982 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1201010004983 Protein export membrane protein; Region: SecD_SecF; cl14618 1201010004984 Protein export membrane protein; Region: SecD_SecF; pfam02355 1201010004985 Preprotein translocase subunit; Region: YajC; pfam02699 1201010004986 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1201010004987 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1201010004988 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1201010004989 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1201010004990 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1201010004991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010004992 Walker A motif; other site 1201010004993 ATP binding site [chemical binding]; other site 1201010004994 Walker B motif; other site 1201010004995 arginine finger; other site 1201010004996 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1201010004997 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1201010004998 RuvA N terminal domain; Region: RuvA_N; pfam01330 1201010004999 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1201010005000 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 1201010005001 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1201010005002 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1201010005003 GTP1/OBG; Region: GTP1_OBG; pfam01018 1201010005004 Obg GTPase; Region: Obg; cd01898 1201010005005 G1 box; other site 1201010005006 GTP/Mg2+ binding site [chemical binding]; other site 1201010005007 Switch I region; other site 1201010005008 G2 box; other site 1201010005009 G3 box; other site 1201010005010 Switch II region; other site 1201010005011 G4 box; other site 1201010005012 G5 box; other site 1201010005013 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1201010005014 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1201010005015 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1201010005016 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1201010005017 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1201010005018 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1201010005019 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1201010005020 rod shape-determining protein MreC; Region: MreC; pfam04085 1201010005021 hypothetical protein; Reviewed; Region: PRK00024 1201010005022 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1201010005023 MPN+ (JAMM) motif; other site 1201010005024 Zinc-binding site [ion binding]; other site 1201010005025 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1201010005026 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1201010005027 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1201010005028 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1201010005029 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1201010005030 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1201010005031 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1201010005032 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1201010005033 active site 1201010005034 HIGH motif; other site 1201010005035 nucleotide binding site [chemical binding]; other site 1201010005036 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1201010005037 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1201010005038 active site 1201010005039 KMSKS motif; other site 1201010005040 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1201010005041 tRNA binding surface [nucleotide binding]; other site 1201010005042 anticodon binding site; other site 1201010005043 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1201010005044 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1201010005045 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1201010005046 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1201010005047 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1201010005048 inhibitor-cofactor binding pocket; inhibition site 1201010005049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010005050 catalytic residue [active] 1201010005051 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1201010005052 dimer interface [polypeptide binding]; other site 1201010005053 active site 1201010005054 Schiff base residues; other site 1201010005055 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1201010005056 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1201010005057 active site 1201010005058 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1201010005059 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1201010005060 domain interfaces; other site 1201010005061 active site 1201010005062 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 1201010005063 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1201010005064 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1201010005065 tRNA; other site 1201010005066 putative tRNA binding site [nucleotide binding]; other site 1201010005067 putative NADP binding site [chemical binding]; other site 1201010005068 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1201010005069 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1201010005070 G1 box; other site 1201010005071 GTP/Mg2+ binding site [chemical binding]; other site 1201010005072 Switch I region; other site 1201010005073 G2 box; other site 1201010005074 G3 box; other site 1201010005075 Switch II region; other site 1201010005076 G4 box; other site 1201010005077 G5 box; other site 1201010005078 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1201010005079 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1201010005080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010005081 Walker A motif; other site 1201010005082 ATP binding site [chemical binding]; other site 1201010005083 Walker B motif; other site 1201010005084 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1201010005085 trigger factor; Provisional; Region: tig; PRK01490 1201010005086 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1201010005087 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1201010005088 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1201010005089 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1201010005090 23S rRNA binding site [nucleotide binding]; other site 1201010005091 L21 binding site [polypeptide binding]; other site 1201010005092 L13 binding site [polypeptide binding]; other site 1201010005093 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1201010005094 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1201010005095 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1201010005096 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1201010005097 lysine transporter; Provisional; Region: PRK10836 1201010005098 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1201010005099 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1201010005100 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1201010005101 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1201010005102 active site 1201010005103 dimer interface [polypeptide binding]; other site 1201010005104 motif 1; other site 1201010005105 motif 2; other site 1201010005106 motif 3; other site 1201010005107 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1201010005108 anticodon binding site; other site 1201010005109 primosomal protein DnaI; Reviewed; Region: PRK08939 1201010005110 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1201010005111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010005112 Walker A motif; other site 1201010005113 ATP binding site [chemical binding]; other site 1201010005114 Walker B motif; other site 1201010005115 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1201010005116 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1201010005117 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1201010005118 ATP cone domain; Region: ATP-cone; pfam03477 1201010005119 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1201010005120 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1201010005121 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1201010005122 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1201010005123 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1201010005124 CoA-binding site [chemical binding]; other site 1201010005125 ATP-binding [chemical binding]; other site 1201010005126 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1201010005127 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1201010005128 DNA binding site [nucleotide binding] 1201010005129 catalytic residue [active] 1201010005130 H2TH interface [polypeptide binding]; other site 1201010005131 putative catalytic residues [active] 1201010005132 turnover-facilitating residue; other site 1201010005133 intercalation triad [nucleotide binding]; other site 1201010005134 8OG recognition residue [nucleotide binding]; other site 1201010005135 putative reading head residues; other site 1201010005136 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1201010005137 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1201010005138 DNA polymerase I; Provisional; Region: PRK05755 1201010005139 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1201010005140 active site 1201010005141 metal binding site 1 [ion binding]; metal-binding site 1201010005142 putative 5' ssDNA interaction site; other site 1201010005143 metal binding site 3; metal-binding site 1201010005144 metal binding site 2 [ion binding]; metal-binding site 1201010005145 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1201010005146 putative DNA binding site [nucleotide binding]; other site 1201010005147 putative metal binding site [ion binding]; other site 1201010005148 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1201010005149 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1201010005150 active site 1201010005151 DNA binding site [nucleotide binding] 1201010005152 catalytic site [active] 1201010005153 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1201010005154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1201010005155 dimer interface [polypeptide binding]; other site 1201010005156 phosphorylation site [posttranslational modification] 1201010005157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010005158 ATP binding site [chemical binding]; other site 1201010005159 Mg2+ binding site [ion binding]; other site 1201010005160 G-X-G motif; other site 1201010005161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1201010005162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010005163 active site 1201010005164 phosphorylation site [posttranslational modification] 1201010005165 intermolecular recognition site; other site 1201010005166 dimerization interface [polypeptide binding]; other site 1201010005167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1201010005168 DNA binding site [nucleotide binding] 1201010005169 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1201010005170 isocitrate dehydrogenase; Validated; Region: PRK07362 1201010005171 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1201010005172 dimer interface [polypeptide binding]; other site 1201010005173 Citrate synthase; Region: Citrate_synt; pfam00285 1201010005174 active site 1201010005175 citrylCoA binding site [chemical binding]; other site 1201010005176 oxalacetate/citrate binding site [chemical binding]; other site 1201010005177 coenzyme A binding site [chemical binding]; other site 1201010005178 catalytic triad [active] 1201010005179 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1201010005180 pyruvate kinase; Provisional; Region: PRK06354 1201010005181 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1201010005182 domain interfaces; other site 1201010005183 active site 1201010005184 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1201010005185 6-phosphofructokinase; Provisional; Region: PRK03202 1201010005186 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1201010005187 active site 1201010005188 ADP/pyrophosphate binding site [chemical binding]; other site 1201010005189 dimerization interface [polypeptide binding]; other site 1201010005190 allosteric effector site; other site 1201010005191 fructose-1,6-bisphosphate binding site; other site 1201010005192 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1201010005193 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1201010005194 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1201010005195 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1201010005196 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1201010005197 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1201010005198 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1201010005199 putative NAD(P) binding site [chemical binding]; other site 1201010005200 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1201010005201 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1201010005202 active site 1201010005203 PHP Thumb interface [polypeptide binding]; other site 1201010005204 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1201010005205 generic binding surface I; other site 1201010005206 generic binding surface II; other site 1201010005207 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1201010005208 DHH family; Region: DHH; pfam01368 1201010005209 DHHA1 domain; Region: DHHA1; pfam02272 1201010005210 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1201010005211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1201010005212 DNA-binding site [nucleotide binding]; DNA binding site 1201010005213 DRTGG domain; Region: DRTGG; pfam07085 1201010005214 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1201010005215 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1201010005216 active site 2 [active] 1201010005217 active site 1 [active] 1201010005218 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1201010005219 Ligand Binding Site [chemical binding]; other site 1201010005220 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1201010005221 metal-dependent hydrolase; Provisional; Region: PRK00685 1201010005222 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1201010005223 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1201010005224 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1201010005225 active site 1201010005226 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1201010005227 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1201010005228 hexamer interface [polypeptide binding]; other site 1201010005229 ligand binding site [chemical binding]; other site 1201010005230 putative active site [active] 1201010005231 NAD(P) binding site [chemical binding]; other site 1201010005232 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1201010005233 Ligand Binding Site [chemical binding]; other site 1201010005234 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1201010005235 propionate/acetate kinase; Provisional; Region: PRK12379 1201010005236 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1201010005237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010005238 S-adenosylmethionine binding site [chemical binding]; other site 1201010005239 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1201010005240 dimer interface [polypeptide binding]; other site 1201010005241 catalytic triad [active] 1201010005242 peroxidatic and resolving cysteines [active] 1201010005243 hypothetical protein; Provisional; Region: PRK10621 1201010005244 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1201010005245 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1201010005246 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1201010005247 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1201010005248 Ligand Binding Site [chemical binding]; other site 1201010005249 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1201010005250 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1201010005251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1201010005252 catalytic residue [active] 1201010005253 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1201010005254 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1201010005255 GAF domain; Region: GAF_2; pfam13185 1201010005256 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1201010005257 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1201010005258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1201010005259 RNA binding surface [nucleotide binding]; other site 1201010005260 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1201010005261 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1201010005262 active site 1201010005263 catalytic site [active] 1201010005264 OsmC-like protein; Region: OsmC; cl00767 1201010005265 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1201010005266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1201010005267 catalytic residue [active] 1201010005268 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1201010005269 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1201010005270 ligand binding site [chemical binding]; other site 1201010005271 NAD binding site [chemical binding]; other site 1201010005272 dimerization interface [polypeptide binding]; other site 1201010005273 catalytic site [active] 1201010005274 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1201010005275 putative L-serine binding site [chemical binding]; other site 1201010005276 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010005277 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1201010005278 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010005279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1201010005280 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1201010005281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010005282 motif II; other site 1201010005283 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1201010005284 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1201010005285 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1201010005286 active site turn [active] 1201010005287 phosphorylation site [posttranslational modification] 1201010005288 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1201010005289 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1201010005290 putative acyl-acceptor binding pocket; other site 1201010005291 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1201010005292 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1201010005293 protein binding site [polypeptide binding]; other site 1201010005294 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1201010005295 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1201010005296 active site 1201010005297 HIGH motif; other site 1201010005298 dimer interface [polypeptide binding]; other site 1201010005299 KMSKS motif; other site 1201010005300 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1201010005301 RNA binding surface [nucleotide binding]; other site 1201010005302 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1201010005303 Transglycosylase; Region: Transgly; pfam00912 1201010005304 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1201010005305 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1201010005306 NEAr Transporter domain; Region: NEAT; smart00725 1201010005307 NEAr Transporter domain; Region: NEAT; smart00725 1201010005308 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1201010005309 heme-binding site [chemical binding]; other site 1201010005310 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1201010005311 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1201010005312 Potassium binding sites [ion binding]; other site 1201010005313 Cesium cation binding sites [ion binding]; other site 1201010005314 acetyl-CoA synthetase; Provisional; Region: PRK04319 1201010005315 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1201010005316 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1201010005317 active site 1201010005318 acyl-activating enzyme (AAE) consensus motif; other site 1201010005319 putative CoA binding site [chemical binding]; other site 1201010005320 AMP binding site [chemical binding]; other site 1201010005321 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1201010005322 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1201010005323 active site 1201010005324 Zn binding site [ion binding]; other site 1201010005325 catabolite control protein A; Region: ccpA; TIGR01481 1201010005326 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1201010005327 DNA binding site [nucleotide binding] 1201010005328 domain linker motif; other site 1201010005329 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1201010005330 dimerization interface [polypeptide binding]; other site 1201010005331 effector binding site; other site 1201010005332 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1201010005333 Chorismate mutase type II; Region: CM_2; cl00693 1201010005334 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1201010005335 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1201010005336 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1201010005337 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1201010005338 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1201010005339 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1201010005340 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1201010005341 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1201010005342 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1201010005343 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1201010005344 putative tRNA-binding site [nucleotide binding]; other site 1201010005345 hypothetical protein; Provisional; Region: PRK13668 1201010005346 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1201010005347 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1201010005348 catalytic residues [active] 1201010005349 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1201010005350 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1201010005351 oligomer interface [polypeptide binding]; other site 1201010005352 active site 1201010005353 metal binding site [ion binding]; metal-binding site 1201010005354 Predicted small secreted protein [Function unknown]; Region: COG5584 1201010005355 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1201010005356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010005357 S-adenosylmethionine binding site [chemical binding]; other site 1201010005358 Phosphotransferase enzyme family; Region: APH; pfam01636 1201010005359 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1201010005360 active site 1201010005361 substrate binding site [chemical binding]; other site 1201010005362 ATP binding site [chemical binding]; other site 1201010005363 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1201010005364 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1201010005365 homodimer interface [polypeptide binding]; other site 1201010005366 substrate-cofactor binding pocket; other site 1201010005367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010005368 catalytic residue [active] 1201010005369 dipeptidase PepV; Reviewed; Region: PRK07318 1201010005370 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1201010005371 active site 1201010005372 metal binding site [ion binding]; metal-binding site 1201010005373 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1201010005374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1201010005375 RNA binding surface [nucleotide binding]; other site 1201010005376 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1201010005377 active site 1201010005378 uracil binding [chemical binding]; other site 1201010005379 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1201010005380 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1201010005381 HI0933-like protein; Region: HI0933_like; pfam03486 1201010005382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1201010005383 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1201010005384 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1201010005385 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005386 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005387 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005388 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005389 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005390 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005391 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005392 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005393 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005394 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005395 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005396 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005397 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005398 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005399 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010005400 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1201010005401 active site residue [active] 1201010005402 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1201010005403 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1201010005404 HIGH motif; other site 1201010005405 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1201010005406 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1201010005407 active site 1201010005408 KMSKS motif; other site 1201010005409 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1201010005410 tRNA binding surface [nucleotide binding]; other site 1201010005411 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010005412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010005413 putative substrate translocation pore; other site 1201010005414 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1201010005415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010005416 S-adenosylmethionine binding site [chemical binding]; other site 1201010005417 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010005418 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1201010005419 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1201010005420 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1201010005421 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1201010005422 homopentamer interface [polypeptide binding]; other site 1201010005423 active site 1201010005424 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1201010005425 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1201010005426 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1201010005427 dimerization interface [polypeptide binding]; other site 1201010005428 active site 1201010005429 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1201010005430 Lumazine binding domain; Region: Lum_binding; pfam00677 1201010005431 Lumazine binding domain; Region: Lum_binding; pfam00677 1201010005432 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1201010005433 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1201010005434 catalytic motif [active] 1201010005435 Zn binding site [ion binding]; other site 1201010005436 RibD C-terminal domain; Region: RibD_C; cl17279 1201010005437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1201010005438 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1201010005439 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1201010005440 arsenical pump membrane protein; Provisional; Region: PRK15445 1201010005441 transmembrane helices; other site 1201010005442 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1201010005443 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1201010005444 active site 1201010005445 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1201010005446 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1201010005447 CAAX protease self-immunity; Region: Abi; pfam02517 1201010005448 CAAX protease self-immunity; Region: Abi; pfam02517 1201010005449 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1201010005450 active site 1201010005451 intersubunit interactions; other site 1201010005452 catalytic residue [active] 1201010005453 camphor resistance protein CrcB; Provisional; Region: PRK14201 1201010005454 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1201010005455 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1201010005456 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1201010005457 active site 1201010005458 catalytic tetrad [active] 1201010005459 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1201010005460 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1201010005461 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1201010005462 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1201010005463 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1201010005464 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1201010005465 active site 1201010005466 substrate-binding site [chemical binding]; other site 1201010005467 metal-binding site [ion binding] 1201010005468 ATP binding site [chemical binding]; other site 1201010005469 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1201010005470 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1201010005471 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1201010005472 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1201010005473 nudix motif; other site 1201010005474 Haemolytic domain; Region: Haemolytic; pfam01809 1201010005475 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1201010005476 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1201010005477 metal binding site [ion binding]; metal-binding site 1201010005478 substrate binding pocket [chemical binding]; other site 1201010005479 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1201010005480 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1201010005481 acyl-activating enzyme (AAE) consensus motif; other site 1201010005482 putative AMP binding site [chemical binding]; other site 1201010005483 putative active site [active] 1201010005484 putative CoA binding site [chemical binding]; other site 1201010005485 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1201010005486 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1201010005487 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1201010005488 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1201010005489 Family description; Region: UvrD_C_2; pfam13538 1201010005490 Polysaccharide lyase family 8, super-sandwich domain; Region: Lyase_8; pfam02278 1201010005491 Polysaccharide lyase family 8, C-terminal beta-sandwich domain; Region: Lyase_8_C; pfam02884 1201010005492 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1201010005493 Peptidase family M23; Region: Peptidase_M23; pfam01551 1201010005494 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1201010005495 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1201010005496 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 1201010005497 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1201010005498 transposase/IS protein; Provisional; Region: PRK09183 1201010005499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010005500 Walker A motif; other site 1201010005501 ATP binding site [chemical binding]; other site 1201010005502 Walker B motif; other site 1201010005503 arginine finger; other site 1201010005504 Winged helix-turn helix; Region: HTH_29; pfam13551 1201010005505 Integrase core domain; Region: rve; pfam00665 1201010005506 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1201010005507 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 1201010005508 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1201010005509 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1201010005510 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1201010005511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1201010005512 ferrochelatase; Provisional; Region: PRK12435 1201010005513 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1201010005514 C-terminal domain interface [polypeptide binding]; other site 1201010005515 active site 1201010005516 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1201010005517 active site 1201010005518 N-terminal domain interface [polypeptide binding]; other site 1201010005519 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1201010005520 substrate binding site [chemical binding]; other site 1201010005521 active site 1201010005522 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1201010005523 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1201010005524 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1201010005525 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1201010005526 Walker A/P-loop; other site 1201010005527 ATP binding site [chemical binding]; other site 1201010005528 Q-loop/lid; other site 1201010005529 ABC transporter signature motif; other site 1201010005530 Walker B; other site 1201010005531 D-loop; other site 1201010005532 H-loop/switch region; other site 1201010005533 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1201010005534 HIT family signature motif; other site 1201010005535 catalytic residue [active] 1201010005536 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1201010005537 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1201010005538 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1201010005539 SurA N-terminal domain; Region: SurA_N_3; cl07813 1201010005540 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1201010005541 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1201010005542 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1201010005543 generic binding surface II; other site 1201010005544 generic binding surface I; other site 1201010005545 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1201010005546 Zn2+ binding site [ion binding]; other site 1201010005547 Mg2+ binding site [ion binding]; other site 1201010005548 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1201010005549 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1201010005550 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 1201010005551 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1201010005552 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1201010005553 active site 1201010005554 metal binding site [ion binding]; metal-binding site 1201010005555 DNA binding site [nucleotide binding] 1201010005556 hypothetical protein; Provisional; Region: PRK13676 1201010005557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1201010005558 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1201010005559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010005560 non-specific DNA binding site [nucleotide binding]; other site 1201010005561 salt bridge; other site 1201010005562 sequence-specific DNA binding site [nucleotide binding]; other site 1201010005563 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1201010005564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010005565 active site 1201010005566 phosphorylation site [posttranslational modification] 1201010005567 intermolecular recognition site; other site 1201010005568 dimerization interface [polypeptide binding]; other site 1201010005569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1201010005570 DNA binding residues [nucleotide binding] 1201010005571 dimerization interface [polypeptide binding]; other site 1201010005572 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1201010005573 GAF domain; Region: GAF_3; pfam13492 1201010005574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1201010005575 Histidine kinase; Region: HisKA_3; pfam07730 1201010005576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010005577 ATP binding site [chemical binding]; other site 1201010005578 Mg2+ binding site [ion binding]; other site 1201010005579 G-X-G motif; other site 1201010005580 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1201010005581 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1201010005582 active site 1201010005583 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1201010005584 Class II fumarases; Region: Fumarase_classII; cd01362 1201010005585 active site 1201010005586 tetramer interface [polypeptide binding]; other site 1201010005587 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1201010005588 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1201010005589 active site 1201010005590 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1201010005591 epoxyqueuosine reductase; Region: TIGR00276 1201010005592 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1201010005593 HEAT repeats; Region: HEAT_2; pfam13646 1201010005594 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1201010005595 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1201010005596 Walker A/P-loop; other site 1201010005597 ATP binding site [chemical binding]; other site 1201010005598 Q-loop/lid; other site 1201010005599 ABC transporter signature motif; other site 1201010005600 Walker B; other site 1201010005601 D-loop; other site 1201010005602 H-loop/switch region; other site 1201010005603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1201010005604 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1201010005605 substrate binding pocket [chemical binding]; other site 1201010005606 membrane-bound complex binding site; other site 1201010005607 hinge residues; other site 1201010005608 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1201010005609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010005610 dimer interface [polypeptide binding]; other site 1201010005611 conserved gate region; other site 1201010005612 putative PBP binding loops; other site 1201010005613 ABC-ATPase subunit interface; other site 1201010005614 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1201010005615 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1201010005616 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1201010005617 metal binding site 2 [ion binding]; metal-binding site 1201010005618 putative DNA binding helix; other site 1201010005619 metal binding site 1 [ion binding]; metal-binding site 1201010005620 dimer interface [polypeptide binding]; other site 1201010005621 structural Zn2+ binding site [ion binding]; other site 1201010005622 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1201010005623 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1201010005624 putative ligand binding site [chemical binding]; other site 1201010005625 NAD binding site [chemical binding]; other site 1201010005626 catalytic site [active] 1201010005627 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1201010005628 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1201010005629 catalytic triad [active] 1201010005630 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1201010005631 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1201010005632 inhibitor-cofactor binding pocket; inhibition site 1201010005633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010005634 catalytic residue [active] 1201010005635 Predicted membrane protein [Function unknown]; Region: COG4129 1201010005636 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1201010005637 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1201010005638 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1201010005639 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1201010005640 Walker A/P-loop; other site 1201010005641 ATP binding site [chemical binding]; other site 1201010005642 Q-loop/lid; other site 1201010005643 ABC transporter signature motif; other site 1201010005644 Walker B; other site 1201010005645 D-loop; other site 1201010005646 H-loop/switch region; other site 1201010005647 hypothetical protein; Provisional; Region: PRK13662 1201010005648 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1201010005649 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1201010005650 minor groove reading motif; other site 1201010005651 helix-hairpin-helix signature motif; other site 1201010005652 substrate binding pocket [chemical binding]; other site 1201010005653 active site 1201010005654 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1201010005655 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1201010005656 DNA binding and oxoG recognition site [nucleotide binding] 1201010005657 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1201010005658 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1201010005659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010005660 Walker A/P-loop; other site 1201010005661 ATP binding site [chemical binding]; other site 1201010005662 Q-loop/lid; other site 1201010005663 ABC transporter signature motif; other site 1201010005664 Walker B; other site 1201010005665 H-loop/switch region; other site 1201010005666 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1201010005667 recombination regulator RecX; Provisional; Region: recX; PRK14135 1201010005668 glycosyltransferase; Provisional; Region: PRK13481 1201010005669 Transglycosylase; Region: Transgly; pfam00912 1201010005670 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1201010005671 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1201010005672 proposed catalytic triad [active] 1201010005673 conserved cys residue [active] 1201010005674 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1201010005675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010005676 FeS/SAM binding site; other site 1201010005677 YfkB-like domain; Region: YfkB; pfam08756 1201010005678 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1201010005679 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1201010005680 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1201010005681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 1201010005682 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1201010005683 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1201010005684 active site 1201010005685 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1201010005686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1201010005687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010005688 active site 1201010005689 phosphorylation site [posttranslational modification] 1201010005690 intermolecular recognition site; other site 1201010005691 dimerization interface [polypeptide binding]; other site 1201010005692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1201010005693 DNA binding residues [nucleotide binding] 1201010005694 dimerization interface [polypeptide binding]; other site 1201010005695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1201010005696 Histidine kinase; Region: HisKA_3; pfam07730 1201010005697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010005698 ATP binding site [chemical binding]; other site 1201010005699 Mg2+ binding site [ion binding]; other site 1201010005700 G-X-G motif; other site 1201010005701 Predicted membrane protein [Function unknown]; Region: COG4758 1201010005702 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1201010005703 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1201010005704 active site 1201010005705 Predicted membrane protein [Function unknown]; Region: COG4129 1201010005706 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1201010005707 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1201010005708 catalytic triad [active] 1201010005709 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1201010005710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1201010005711 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1201010005712 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1201010005713 Ferritin-like domain; Region: Ferritin; pfam00210 1201010005714 ferroxidase diiron center [ion binding]; other site 1201010005715 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1201010005716 active site 1201010005717 catalytic site [active] 1201010005718 substrate binding site [chemical binding]; other site 1201010005719 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1201010005720 active site 1201010005721 DNA polymerase IV; Validated; Region: PRK02406 1201010005722 DNA binding site [nucleotide binding] 1201010005723 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1201010005724 TRAM domain; Region: TRAM; cl01282 1201010005725 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1201010005726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010005727 S-adenosylmethionine binding site [chemical binding]; other site 1201010005728 putative lipid kinase; Reviewed; Region: PRK13337 1201010005729 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1201010005730 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1201010005731 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1201010005732 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1201010005733 GatB domain; Region: GatB_Yqey; pfam02637 1201010005734 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1201010005735 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1201010005736 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1201010005737 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1201010005738 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1201010005739 Na binding site [ion binding]; other site 1201010005740 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1201010005741 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1201010005742 putative dimer interface [polypeptide binding]; other site 1201010005743 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1201010005744 putative dimer interface [polypeptide binding]; other site 1201010005745 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1201010005746 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1201010005747 nucleotide binding pocket [chemical binding]; other site 1201010005748 K-X-D-G motif; other site 1201010005749 catalytic site [active] 1201010005750 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1201010005751 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1201010005752 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1201010005753 Dimer interface [polypeptide binding]; other site 1201010005754 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1201010005755 Part of AAA domain; Region: AAA_19; pfam13245 1201010005756 Family description; Region: UvrD_C_2; pfam13538 1201010005757 PcrB family; Region: PcrB; pfam01884 1201010005758 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1201010005759 substrate binding site [chemical binding]; other site 1201010005760 putative active site [active] 1201010005761 dimer interface [polypeptide binding]; other site 1201010005762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1201010005763 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1201010005764 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1201010005765 tetramer interface [polypeptide binding]; other site 1201010005766 active site 1201010005767 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1201010005768 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1201010005769 NETI protein; Region: NETI; pfam14044 1201010005770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1201010005771 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1201010005772 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1201010005773 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1201010005774 homodimer interface [polypeptide binding]; other site 1201010005775 NAD binding pocket [chemical binding]; other site 1201010005776 ATP binding pocket [chemical binding]; other site 1201010005777 Mg binding site [ion binding]; other site 1201010005778 active-site loop [active] 1201010005779 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1201010005780 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1201010005781 active site 1201010005782 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1201010005783 active site 1201010005784 dimer interface [polypeptide binding]; other site 1201010005785 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1201010005786 Prephenate dehydratase; Region: PDT; pfam00800 1201010005787 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1201010005788 putative L-Phe binding site [chemical binding]; other site 1201010005789 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1201010005790 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1201010005791 transmembrane helices; other site 1201010005792 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1201010005793 Isochorismatase family; Region: Isochorismatase; pfam00857 1201010005794 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1201010005795 catalytic triad [active] 1201010005796 conserved cis-peptide bond; other site 1201010005797 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1201010005798 DHH family; Region: DHH; pfam01368 1201010005799 DHHA2 domain; Region: DHHA2; pfam02833 1201010005800 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1201010005801 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1201010005802 NAD(P) binding site [chemical binding]; other site 1201010005803 catalytic residues [active] 1201010005804 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1201010005805 YolD-like protein; Region: YolD; pfam08863 1201010005806 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 1201010005807 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1201010005808 active site 1201010005809 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1201010005810 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1201010005811 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1201010005812 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1201010005813 Bacterial PH domain; Region: DUF304; cl01348 1201010005814 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1201010005815 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1201010005816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1201010005817 Walker A/P-loop; other site 1201010005818 ATP binding site [chemical binding]; other site 1201010005819 Q-loop/lid; other site 1201010005820 ABC transporter signature motif; other site 1201010005821 Walker B; other site 1201010005822 D-loop; other site 1201010005823 H-loop/switch region; other site 1201010005824 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1201010005825 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1201010005826 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1201010005827 Walker A/P-loop; other site 1201010005828 ATP binding site [chemical binding]; other site 1201010005829 Q-loop/lid; other site 1201010005830 ABC transporter signature motif; other site 1201010005831 Walker B; other site 1201010005832 D-loop; other site 1201010005833 H-loop/switch region; other site 1201010005834 Predicted transcriptional regulators [Transcription]; Region: COG1725 1201010005835 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1201010005836 DNA-binding site [nucleotide binding]; DNA binding site 1201010005837 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1201010005838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1201010005839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010005840 homodimer interface [polypeptide binding]; other site 1201010005841 catalytic residue [active] 1201010005842 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1201010005843 putative catalytic site [active] 1201010005844 metal binding site A [ion binding]; metal-binding site 1201010005845 phosphate binding site [ion binding]; other site 1201010005846 metal binding site C [ion binding]; metal-binding site 1201010005847 metal binding site B [ion binding]; metal-binding site 1201010005848 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1201010005849 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1201010005850 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1201010005851 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1201010005852 metal binding site [ion binding]; metal-binding site 1201010005853 dimer interface [polypeptide binding]; other site 1201010005854 Cation transport protein; Region: TrkH; cl17365 1201010005855 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1201010005856 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1201010005857 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1201010005858 ring oligomerisation interface [polypeptide binding]; other site 1201010005859 ATP/Mg binding site [chemical binding]; other site 1201010005860 stacking interactions; other site 1201010005861 hinge regions; other site 1201010005862 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1201010005863 oligomerisation interface [polypeptide binding]; other site 1201010005864 mobile loop; other site 1201010005865 roof hairpin; other site 1201010005866 CAAX protease self-immunity; Region: Abi; pfam02517 1201010005867 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1201010005868 dimer interface [polypeptide binding]; other site 1201010005869 FMN binding site [chemical binding]; other site 1201010005870 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1201010005871 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1201010005872 putative active site [active] 1201010005873 catalytic triad [active] 1201010005874 putative dimer interface [polypeptide binding]; other site 1201010005875 delta-hemolysin; Provisional; Region: PRK14752 1201010005876 Accessory gene regulator B; Region: AgrB; smart00793 1201010005877 Staphylococcal AgrD protein; Region: AgrD; smart00794 1201010005878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010005879 Mg2+ binding site [ion binding]; other site 1201010005880 G-X-G motif; other site 1201010005881 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1201010005882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010005883 active site 1201010005884 phosphorylation site [posttranslational modification] 1201010005885 intermolecular recognition site; other site 1201010005886 dimerization interface [polypeptide binding]; other site 1201010005887 LytTr DNA-binding domain; Region: LytTR; pfam04397 1201010005888 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1201010005889 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1201010005890 putative substrate binding site [chemical binding]; other site 1201010005891 putative ATP binding site [chemical binding]; other site 1201010005892 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1201010005893 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1201010005894 substrate binding [chemical binding]; other site 1201010005895 active site 1201010005896 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1201010005897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1201010005898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1201010005899 DNA binding site [nucleotide binding] 1201010005900 domain linker motif; other site 1201010005901 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1201010005902 dimerization interface [polypeptide binding]; other site 1201010005903 ligand binding site [chemical binding]; other site 1201010005904 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1201010005905 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1201010005906 CPxP motif; other site 1201010005907 Predicted transporter component [General function prediction only]; Region: COG2391 1201010005908 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1201010005909 Sulphur transport; Region: Sulf_transp; pfam04143 1201010005910 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1201010005911 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1201010005912 CoA binding domain; Region: CoA_binding; pfam02629 1201010005913 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1201010005914 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1201010005915 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1201010005916 ABC transporter; Region: ABC_tran_2; pfam12848 1201010005917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1201010005918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1201010005919 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1201010005920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010005921 Walker A/P-loop; other site 1201010005922 ATP binding site [chemical binding]; other site 1201010005923 Q-loop/lid; other site 1201010005924 ABC transporter signature motif; other site 1201010005925 Walker B; other site 1201010005926 D-loop; other site 1201010005927 H-loop/switch region; other site 1201010005928 UGMP family protein; Validated; Region: PRK09604 1201010005929 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1201010005930 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1201010005931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010005932 Coenzyme A binding pocket [chemical binding]; other site 1201010005933 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1201010005934 Glycoprotease family; Region: Peptidase_M22; pfam00814 1201010005935 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1201010005936 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1201010005937 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1201010005938 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1201010005939 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1201010005940 PYR/PP interface [polypeptide binding]; other site 1201010005941 dimer interface [polypeptide binding]; other site 1201010005942 TPP binding site [chemical binding]; other site 1201010005943 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1201010005944 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1201010005945 TPP-binding site [chemical binding]; other site 1201010005946 dimer interface [polypeptide binding]; other site 1201010005947 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 1201010005948 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1201010005949 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1201010005950 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1201010005951 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1201010005952 2-isopropylmalate synthase; Validated; Region: PRK00915 1201010005953 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1201010005954 active site 1201010005955 catalytic residues [active] 1201010005956 metal binding site [ion binding]; metal-binding site 1201010005957 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1201010005958 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1201010005959 tartrate dehydrogenase; Region: TTC; TIGR02089 1201010005960 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1201010005961 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1201010005962 substrate binding site [chemical binding]; other site 1201010005963 ligand binding site [chemical binding]; other site 1201010005964 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1201010005965 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1201010005966 substrate binding site [chemical binding]; other site 1201010005967 threonine dehydratase; Validated; Region: PRK08639 1201010005968 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1201010005969 tetramer interface [polypeptide binding]; other site 1201010005970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010005971 catalytic residue [active] 1201010005972 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1201010005973 putative Ile/Val binding site [chemical binding]; other site 1201010005974 hypothetical protein; Provisional; Region: PRK04351 1201010005975 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1201010005976 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1201010005977 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1201010005978 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1201010005979 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1201010005980 RNA binding site [nucleotide binding]; other site 1201010005981 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1201010005982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1201010005983 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1201010005984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1201010005985 DNA binding residues [nucleotide binding] 1201010005986 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1201010005987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010005988 ATP binding site [chemical binding]; other site 1201010005989 Mg2+ binding site [ion binding]; other site 1201010005990 G-X-G motif; other site 1201010005991 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1201010005992 anti sigma factor interaction site; other site 1201010005993 regulatory phosphorylation site [posttranslational modification]; other site 1201010005994 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1201010005995 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1201010005996 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1201010005997 PemK-like protein; Region: PemK; pfam02452 1201010005998 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1201010005999 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1201010006000 active site 1201010006001 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1201010006002 dimer interface [polypeptide binding]; other site 1201010006003 substrate binding site [chemical binding]; other site 1201010006004 catalytic residues [active] 1201010006005 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1201010006006 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1201010006007 Predicted membrane protein [Function unknown]; Region: COG3428 1201010006008 Bacterial PH domain; Region: DUF304; pfam03703 1201010006009 Bacterial PH domain; Region: DUF304; pfam03703 1201010006010 Bacterial PH domain; Region: DUF304; cl01348 1201010006011 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1201010006012 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1201010006013 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1201010006014 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1201010006015 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1201010006016 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1201010006017 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1201010006018 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1201010006019 Ligand Binding Site [chemical binding]; other site 1201010006020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1201010006021 dimer interface [polypeptide binding]; other site 1201010006022 phosphorylation site [posttranslational modification] 1201010006023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010006024 ATP binding site [chemical binding]; other site 1201010006025 Mg2+ binding site [ion binding]; other site 1201010006026 G-X-G motif; other site 1201010006027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1201010006028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010006029 active site 1201010006030 phosphorylation site [posttranslational modification] 1201010006031 intermolecular recognition site; other site 1201010006032 dimerization interface [polypeptide binding]; other site 1201010006033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1201010006034 DNA binding site [nucleotide binding] 1201010006035 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1201010006036 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1201010006037 ATP binding site [chemical binding]; other site 1201010006038 Mg++ binding site [ion binding]; other site 1201010006039 motif III; other site 1201010006040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1201010006041 nucleotide binding region [chemical binding]; other site 1201010006042 ATP-binding site [chemical binding]; other site 1201010006043 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1201010006044 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1201010006045 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1201010006046 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1201010006047 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1201010006048 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1201010006049 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1201010006050 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1201010006051 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1201010006052 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1201010006053 putative homodimer interface [polypeptide binding]; other site 1201010006054 putative homotetramer interface [polypeptide binding]; other site 1201010006055 allosteric switch controlling residues; other site 1201010006056 putative metal binding site [ion binding]; other site 1201010006057 putative homodimer-homodimer interface [polypeptide binding]; other site 1201010006058 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1201010006059 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1201010006060 putative active site [active] 1201010006061 catalytic site [active] 1201010006062 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1201010006063 putative active site [active] 1201010006064 catalytic site [active] 1201010006065 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1201010006066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1201010006067 Zn2+ binding site [ion binding]; other site 1201010006068 Mg2+ binding site [ion binding]; other site 1201010006069 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1201010006070 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1201010006071 thiamine phosphate binding site [chemical binding]; other site 1201010006072 active site 1201010006073 pyrophosphate binding site [ion binding]; other site 1201010006074 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1201010006075 substrate binding site [chemical binding]; other site 1201010006076 multimerization interface [polypeptide binding]; other site 1201010006077 ATP binding site [chemical binding]; other site 1201010006078 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1201010006079 dimer interface [polypeptide binding]; other site 1201010006080 substrate binding site [chemical binding]; other site 1201010006081 ATP binding site [chemical binding]; other site 1201010006082 thiaminase II; Region: salvage_TenA; TIGR04306 1201010006083 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1201010006084 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1201010006085 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1201010006086 dimer interface [polypeptide binding]; other site 1201010006087 ssDNA binding site [nucleotide binding]; other site 1201010006088 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1201010006089 transposase/IS protein; Provisional; Region: PRK09183 1201010006090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010006091 Walker A motif; other site 1201010006092 ATP binding site [chemical binding]; other site 1201010006093 Walker B motif; other site 1201010006094 arginine finger; other site 1201010006095 Winged helix-turn helix; Region: HTH_29; pfam13551 1201010006096 Integrase core domain; Region: rve; pfam00665 1201010006097 YwpF-like protein; Region: YwpF; pfam14183 1201010006098 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1201010006099 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1201010006100 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1201010006101 hinge; other site 1201010006102 active site 1201010006103 Predicted membrane protein [Function unknown]; Region: COG4836 1201010006104 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 1201010006105 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1201010006106 gamma subunit interface [polypeptide binding]; other site 1201010006107 epsilon subunit interface [polypeptide binding]; other site 1201010006108 LBP interface [polypeptide binding]; other site 1201010006109 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1201010006110 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1201010006111 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1201010006112 alpha subunit interaction interface [polypeptide binding]; other site 1201010006113 Walker A motif; other site 1201010006114 ATP binding site [chemical binding]; other site 1201010006115 Walker B motif; other site 1201010006116 inhibitor binding site; inhibition site 1201010006117 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1201010006118 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1201010006119 core domain interface [polypeptide binding]; other site 1201010006120 delta subunit interface [polypeptide binding]; other site 1201010006121 epsilon subunit interface [polypeptide binding]; other site 1201010006122 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1201010006123 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1201010006124 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1201010006125 beta subunit interaction interface [polypeptide binding]; other site 1201010006126 Walker A motif; other site 1201010006127 ATP binding site [chemical binding]; other site 1201010006128 Walker B motif; other site 1201010006129 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1201010006130 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1201010006131 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1201010006132 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1201010006133 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1201010006134 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1201010006135 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1201010006136 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1201010006137 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1201010006138 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1201010006139 active site 1201010006140 homodimer interface [polypeptide binding]; other site 1201010006141 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1201010006142 active site 1201010006143 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1201010006144 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1201010006145 dimer interface [polypeptide binding]; other site 1201010006146 active site 1201010006147 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1201010006148 folate binding site [chemical binding]; other site 1201010006149 hypothetical protein; Provisional; Region: PRK13690 1201010006150 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1201010006151 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1201010006152 active site 1201010006153 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1201010006154 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1201010006155 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1201010006156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010006157 S-adenosylmethionine binding site [chemical binding]; other site 1201010006158 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1201010006159 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1201010006160 RF-1 domain; Region: RF-1; pfam00472 1201010006161 thymidine kinase; Provisional; Region: PRK04296 1201010006162 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1201010006163 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1201010006164 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1201010006165 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1201010006166 RNA binding site [nucleotide binding]; other site 1201010006167 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1201010006168 multimer interface [polypeptide binding]; other site 1201010006169 Walker A motif; other site 1201010006170 ATP binding site [chemical binding]; other site 1201010006171 Walker B motif; other site 1201010006172 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1201010006173 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1201010006174 NAD binding site [chemical binding]; other site 1201010006175 catalytic residues [active] 1201010006176 Predicted transcriptional regulators [Transcription]; Region: COG1733 1201010006177 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1201010006178 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1201010006179 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1201010006180 hinge; other site 1201010006181 active site 1201010006182 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1201010006183 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1201010006184 intersubunit interface [polypeptide binding]; other site 1201010006185 active site 1201010006186 zinc binding site [ion binding]; other site 1201010006187 Na+ binding site [ion binding]; other site 1201010006188 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1201010006189 CTP synthetase; Validated; Region: pyrG; PRK05380 1201010006190 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1201010006191 Catalytic site [active] 1201010006192 active site 1201010006193 UTP binding site [chemical binding]; other site 1201010006194 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1201010006195 active site 1201010006196 putative oxyanion hole; other site 1201010006197 catalytic triad [active] 1201010006198 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1201010006199 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1201010006200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010006201 Coenzyme A binding pocket [chemical binding]; other site 1201010006202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1201010006203 Coenzyme A binding pocket [chemical binding]; other site 1201010006204 pantothenate kinase; Provisional; Region: PRK13317 1201010006205 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1201010006206 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1201010006207 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1201010006208 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1201010006209 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1201010006210 metal binding site [ion binding]; metal-binding site 1201010006211 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1201010006212 Predicted membrane protein [Function unknown]; Region: COG4270 1201010006213 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1201010006214 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1201010006215 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1201010006216 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1201010006217 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1201010006218 intersubunit interface [polypeptide binding]; other site 1201010006219 active site 1201010006220 catalytic residue [active] 1201010006221 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1201010006222 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1201010006223 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1201010006224 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1201010006225 dimerization interface [polypeptide binding]; other site 1201010006226 DPS ferroxidase diiron center [ion binding]; other site 1201010006227 ion pore; other site 1201010006228 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1201010006229 EVE domain; Region: EVE; cl00728 1201010006230 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1201010006231 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1201010006232 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1201010006233 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1201010006234 NAD(P) binding site [chemical binding]; other site 1201010006235 putative active site [active] 1201010006236 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1201010006237 dimerization interface [polypeptide binding]; other site 1201010006238 putative DNA binding site [nucleotide binding]; other site 1201010006239 putative Zn2+ binding site [ion binding]; other site 1201010006240 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1201010006241 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1201010006242 SAP domain; Region: SAP; pfam02037 1201010006243 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1201010006244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010006245 active site 1201010006246 motif I; other site 1201010006247 motif II; other site 1201010006248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010006249 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1201010006250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010006251 Walker A/P-loop; other site 1201010006252 ATP binding site [chemical binding]; other site 1201010006253 Q-loop/lid; other site 1201010006254 ABC transporter signature motif; other site 1201010006255 Walker B; other site 1201010006256 D-loop; other site 1201010006257 H-loop/switch region; other site 1201010006258 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1201010006259 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1201010006260 glutaminase active site [active] 1201010006261 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1201010006262 dimer interface [polypeptide binding]; other site 1201010006263 active site 1201010006264 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1201010006265 dimer interface [polypeptide binding]; other site 1201010006266 active site 1201010006267 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1201010006268 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1201010006269 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1201010006270 active site 1201010006271 P-loop; other site 1201010006272 phosphorylation site [posttranslational modification] 1201010006273 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1201010006274 HTH domain; Region: HTH_11; pfam08279 1201010006275 Mga helix-turn-helix domain; Region: Mga; pfam05043 1201010006276 PRD domain; Region: PRD; pfam00874 1201010006277 PRD domain; Region: PRD; pfam00874 1201010006278 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1201010006279 active site 1201010006280 P-loop; other site 1201010006281 phosphorylation site [posttranslational modification] 1201010006282 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1201010006283 active site 1201010006284 phosphorylation site [posttranslational modification] 1201010006285 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1201010006286 active site 1201010006287 phosphorylation site [posttranslational modification] 1201010006288 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1201010006289 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1201010006290 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1201010006291 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1201010006292 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1201010006293 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010006294 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010006295 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010006296 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010006297 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010006298 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010006299 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010006300 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010006301 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1201010006302 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1201010006303 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1201010006304 active site 1201010006305 substrate binding site [chemical binding]; other site 1201010006306 metal binding site [ion binding]; metal-binding site 1201010006307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1201010006308 YbbR-like protein; Region: YbbR; pfam07949 1201010006309 YbbR-like protein; Region: YbbR; pfam07949 1201010006310 TIGR00159 family protein; Region: TIGR00159 1201010006311 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1201010006312 Arginase family; Region: Arginase; cd09989 1201010006313 active site 1201010006314 Mn binding site [ion binding]; other site 1201010006315 oligomer interface [polypeptide binding]; other site 1201010006316 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1201010006317 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1201010006318 Walker A motif; other site 1201010006319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006320 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010006321 putative substrate translocation pore; other site 1201010006322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006323 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010006324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006325 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1201010006326 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1201010006327 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1201010006328 substrate binding site; other site 1201010006329 dimerization interface; other site 1201010006330 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1201010006331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1201010006332 Nucleoside recognition; Region: Gate; pfam07670 1201010006333 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1201010006334 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010006335 ABC-ATPase subunit interface; other site 1201010006336 dimer interface [polypeptide binding]; other site 1201010006337 putative PBP binding regions; other site 1201010006338 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1201010006339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1201010006340 ABC-ATPase subunit interface; other site 1201010006341 dimer interface [polypeptide binding]; other site 1201010006342 putative PBP binding regions; other site 1201010006343 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1201010006344 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1201010006345 siderophore binding site; other site 1201010006346 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1201010006347 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1201010006348 dimer interface [polypeptide binding]; other site 1201010006349 active site 1201010006350 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1201010006351 substrate binding site [chemical binding]; other site 1201010006352 catalytic residue [active] 1201010006353 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1201010006354 IucA / IucC family; Region: IucA_IucC; pfam04183 1201010006355 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1201010006356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006357 putative substrate translocation pore; other site 1201010006358 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1201010006359 IucA / IucC family; Region: IucA_IucC; pfam04183 1201010006360 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1201010006361 Asp23 family; Region: Asp23; pfam03780 1201010006362 Small integral membrane protein [Function unknown]; Region: COG5547 1201010006363 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1201010006364 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1201010006365 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1201010006366 putative NAD(P) binding site [chemical binding]; other site 1201010006367 dimer interface [polypeptide binding]; other site 1201010006368 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1201010006369 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1201010006370 NAD(P) binding site [chemical binding]; other site 1201010006371 substrate binding site [chemical binding]; other site 1201010006372 dimer interface [polypeptide binding]; other site 1201010006373 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1201010006374 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1201010006375 beta-galactosidase; Region: BGL; TIGR03356 1201010006376 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1201010006377 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1201010006378 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1201010006379 active site 1201010006380 P-loop; other site 1201010006381 phosphorylation site [posttranslational modification] 1201010006382 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1201010006383 methionine cluster; other site 1201010006384 active site 1201010006385 phosphorylation site [posttranslational modification] 1201010006386 metal binding site [ion binding]; metal-binding site 1201010006387 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1201010006388 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1201010006389 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1201010006390 putative substrate binding site [chemical binding]; other site 1201010006391 putative ATP binding site [chemical binding]; other site 1201010006392 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1201010006393 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1201010006394 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1201010006395 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1201010006396 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1201010006397 NAD-dependent deacetylase; Provisional; Region: PRK00481 1201010006398 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1201010006399 NAD+ binding site [chemical binding]; other site 1201010006400 substrate binding site [chemical binding]; other site 1201010006401 putative Zn binding site [ion binding]; other site 1201010006402 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1201010006403 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1201010006404 active site 1201010006405 catalytic tetrad [active] 1201010006406 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1201010006407 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1201010006408 DNA binding residues [nucleotide binding] 1201010006409 putative dimer interface [polypeptide binding]; other site 1201010006410 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1201010006411 substrate binding site [chemical binding]; other site 1201010006412 catalytic residues [active] 1201010006413 Predicted transcriptional regulator [Transcription]; Region: COG2378 1201010006414 HTH domain; Region: HTH_11; pfam08279 1201010006415 WYL domain; Region: WYL; pfam13280 1201010006416 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1201010006417 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1201010006418 conserved cys residue [active] 1201010006419 MAP domain; Region: MAP; pfam03642 1201010006420 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1201010006421 acetolactate synthase; Reviewed; Region: PRK08617 1201010006422 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1201010006423 PYR/PP interface [polypeptide binding]; other site 1201010006424 dimer interface [polypeptide binding]; other site 1201010006425 TPP binding site [chemical binding]; other site 1201010006426 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1201010006427 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1201010006428 TPP-binding site [chemical binding]; other site 1201010006429 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1201010006430 Divergent AAA domain; Region: AAA_4; pfam04326 1201010006431 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1201010006432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1201010006433 putative DNA binding site [nucleotide binding]; other site 1201010006434 putative Zn2+ binding site [ion binding]; other site 1201010006435 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1201010006436 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1201010006437 23S rRNA interface [nucleotide binding]; other site 1201010006438 L3 interface [polypeptide binding]; other site 1201010006439 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1201010006440 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1201010006441 dimerization interface 3.5A [polypeptide binding]; other site 1201010006442 active site 1201010006443 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1201010006444 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1201010006445 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1201010006446 Walker A/P-loop; other site 1201010006447 ATP binding site [chemical binding]; other site 1201010006448 Q-loop/lid; other site 1201010006449 ABC transporter signature motif; other site 1201010006450 Walker B; other site 1201010006451 D-loop; other site 1201010006452 H-loop/switch region; other site 1201010006453 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1201010006454 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1201010006455 Walker A/P-loop; other site 1201010006456 ATP binding site [chemical binding]; other site 1201010006457 Q-loop/lid; other site 1201010006458 ABC transporter signature motif; other site 1201010006459 Walker B; other site 1201010006460 D-loop; other site 1201010006461 H-loop/switch region; other site 1201010006462 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1201010006463 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1201010006464 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1201010006465 alphaNTD homodimer interface [polypeptide binding]; other site 1201010006466 alphaNTD - beta interaction site [polypeptide binding]; other site 1201010006467 alphaNTD - beta' interaction site [polypeptide binding]; other site 1201010006468 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1201010006469 30S ribosomal protein S11; Validated; Region: PRK05309 1201010006470 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1201010006471 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1201010006472 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1201010006473 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1201010006474 rRNA binding site [nucleotide binding]; other site 1201010006475 predicted 30S ribosome binding site; other site 1201010006476 adenylate kinase; Reviewed; Region: adk; PRK00279 1201010006477 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1201010006478 AMP-binding site [chemical binding]; other site 1201010006479 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1201010006480 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1201010006481 SecY translocase; Region: SecY; pfam00344 1201010006482 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1201010006483 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1201010006484 23S rRNA binding site [nucleotide binding]; other site 1201010006485 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1201010006486 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1201010006487 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1201010006488 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1201010006489 5S rRNA interface [nucleotide binding]; other site 1201010006490 L27 interface [polypeptide binding]; other site 1201010006491 23S rRNA interface [nucleotide binding]; other site 1201010006492 L5 interface [polypeptide binding]; other site 1201010006493 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1201010006494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1201010006495 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1201010006496 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1201010006497 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1201010006498 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1201010006499 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1201010006500 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1201010006501 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1201010006502 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1201010006503 RNA binding site [nucleotide binding]; other site 1201010006504 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1201010006505 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1201010006506 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1201010006507 23S rRNA interface [nucleotide binding]; other site 1201010006508 putative translocon interaction site; other site 1201010006509 signal recognition particle (SRP54) interaction site; other site 1201010006510 L23 interface [polypeptide binding]; other site 1201010006511 trigger factor interaction site; other site 1201010006512 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1201010006513 23S rRNA interface [nucleotide binding]; other site 1201010006514 5S rRNA interface [nucleotide binding]; other site 1201010006515 putative antibiotic binding site [chemical binding]; other site 1201010006516 L25 interface [polypeptide binding]; other site 1201010006517 L27 interface [polypeptide binding]; other site 1201010006518 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1201010006519 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1201010006520 G-X-X-G motif; other site 1201010006521 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1201010006522 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1201010006523 putative translocon binding site; other site 1201010006524 protein-rRNA interface [nucleotide binding]; other site 1201010006525 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1201010006526 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1201010006527 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1201010006528 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1201010006529 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1201010006530 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1201010006531 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1201010006532 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1201010006533 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1201010006534 DNA topoisomerase III; Provisional; Region: PRK07726 1201010006535 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1201010006536 active site 1201010006537 putative interdomain interaction site [polypeptide binding]; other site 1201010006538 putative metal-binding site [ion binding]; other site 1201010006539 putative nucleotide binding site [chemical binding]; other site 1201010006540 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1201010006541 domain I; other site 1201010006542 DNA binding groove [nucleotide binding] 1201010006543 phosphate binding site [ion binding]; other site 1201010006544 domain II; other site 1201010006545 domain III; other site 1201010006546 nucleotide binding site [chemical binding]; other site 1201010006547 catalytic site [active] 1201010006548 domain IV; other site 1201010006549 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1201010006550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010006551 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1201010006552 Coenzyme A binding pocket [chemical binding]; other site 1201010006553 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1201010006554 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1201010006555 Predicted permeases [General function prediction only]; Region: COG0679 1201010006556 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1201010006557 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1201010006558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1201010006559 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1201010006560 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1201010006561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006562 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010006563 putative substrate translocation pore; other site 1201010006564 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010006565 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1201010006566 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1201010006567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010006568 FeS/SAM binding site; other site 1201010006569 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1201010006570 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1201010006571 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1201010006572 GTP binding site; other site 1201010006573 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1201010006574 MoaE interaction surface [polypeptide binding]; other site 1201010006575 MoeB interaction surface [polypeptide binding]; other site 1201010006576 thiocarboxylated glycine; other site 1201010006577 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1201010006578 MoaE homodimer interface [polypeptide binding]; other site 1201010006579 MoaD interaction [polypeptide binding]; other site 1201010006580 active site residues [active] 1201010006581 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1201010006582 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1201010006583 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1201010006584 dimer interface [polypeptide binding]; other site 1201010006585 putative functional site; other site 1201010006586 putative MPT binding site; other site 1201010006587 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1201010006588 trimer interface [polypeptide binding]; other site 1201010006589 dimer interface [polypeptide binding]; other site 1201010006590 putative active site [active] 1201010006591 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1201010006592 MPT binding site; other site 1201010006593 trimer interface [polypeptide binding]; other site 1201010006594 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1201010006595 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1201010006596 ATP binding site [chemical binding]; other site 1201010006597 substrate interface [chemical binding]; other site 1201010006598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010006599 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1201010006600 Walker A/P-loop; other site 1201010006601 ATP binding site [chemical binding]; other site 1201010006602 Q-loop/lid; other site 1201010006603 ABC transporter signature motif; other site 1201010006604 Walker B; other site 1201010006605 D-loop; other site 1201010006606 H-loop/switch region; other site 1201010006607 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1201010006608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010006609 dimer interface [polypeptide binding]; other site 1201010006610 conserved gate region; other site 1201010006611 putative PBP binding loops; other site 1201010006612 ABC-ATPase subunit interface; other site 1201010006613 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1201010006614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1201010006615 substrate binding pocket [chemical binding]; other site 1201010006616 membrane-bound complex binding site; other site 1201010006617 hinge residues; other site 1201010006618 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1201010006619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010006620 Coenzyme A binding pocket [chemical binding]; other site 1201010006621 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1201010006622 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1201010006623 active site 1201010006624 dimerization interface [polypeptide binding]; other site 1201010006625 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1201010006626 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1201010006627 intersubunit interface [polypeptide binding]; other site 1201010006628 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1201010006629 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1201010006630 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1201010006631 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1201010006632 alpha-gamma subunit interface [polypeptide binding]; other site 1201010006633 beta-gamma subunit interface [polypeptide binding]; other site 1201010006634 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1201010006635 gamma-beta subunit interface [polypeptide binding]; other site 1201010006636 alpha-beta subunit interface [polypeptide binding]; other site 1201010006637 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1201010006638 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1201010006639 subunit interactions [polypeptide binding]; other site 1201010006640 active site 1201010006641 flap region; other site 1201010006642 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1201010006643 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1201010006644 dimer interface [polypeptide binding]; other site 1201010006645 catalytic residues [active] 1201010006646 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1201010006647 UreF; Region: UreF; pfam01730 1201010006648 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1201010006649 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1201010006650 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010006651 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010006652 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010006653 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1201010006654 Helix-turn-helix domain; Region: HTH_18; pfam12833 1201010006655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1201010006656 Surface antigen [General function prediction only]; Region: COG3942 1201010006657 CHAP domain; Region: CHAP; pfam05257 1201010006658 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1201010006659 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1201010006660 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1201010006661 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1201010006662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1201010006663 Surface antigen [General function prediction only]; Region: COG3942 1201010006664 CHAP domain; Region: CHAP; pfam05257 1201010006665 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1201010006666 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1201010006667 putative ligand binding site [chemical binding]; other site 1201010006668 putative NAD binding site [chemical binding]; other site 1201010006669 catalytic site [active] 1201010006670 hypothetical protein; Provisional; Region: PRK06753 1201010006671 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1201010006672 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1201010006673 Lysozyme subfamily 2; Region: LYZ2; smart00047 1201010006674 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1201010006675 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1201010006676 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1201010006677 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1201010006678 4Fe-4S binding domain; Region: Fer4; pfam00037 1201010006679 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1201010006680 [4Fe-4S] binding site [ion binding]; other site 1201010006681 molybdopterin cofactor binding site; other site 1201010006682 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1201010006683 molybdopterin cofactor binding site; other site 1201010006684 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1201010006685 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1201010006686 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1201010006687 active site 1201010006688 Predicted transcriptional regulator [Transcription]; Region: COG2378 1201010006689 HTH domain; Region: HTH_11; pfam08279 1201010006690 CAAX protease self-immunity; Region: Abi; pfam02517 1201010006691 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1201010006692 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1201010006693 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1201010006694 putative active site [active] 1201010006695 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1201010006696 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1201010006697 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010006698 active site 1201010006699 motif I; other site 1201010006700 motif II; other site 1201010006701 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1201010006702 Sodium Bile acid symporter family; Region: SBF; pfam01758 1201010006703 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1201010006704 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1201010006705 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1201010006706 active site turn [active] 1201010006707 phosphorylation site [posttranslational modification] 1201010006708 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1201010006709 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1201010006710 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1201010006711 putative active site [active] 1201010006712 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1201010006713 putative hydrophobic ligand binding site [chemical binding]; other site 1201010006714 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1201010006715 oxidoreductase; Provisional; Region: PRK07985 1201010006716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1201010006717 NAD(P) binding site [chemical binding]; other site 1201010006718 active site 1201010006719 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1201010006720 amidohydrolase; Region: amidohydrolases; TIGR01891 1201010006721 metal binding site [ion binding]; metal-binding site 1201010006722 dimer interface [polypeptide binding]; other site 1201010006723 imidazolonepropionase; Validated; Region: PRK09356 1201010006724 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1201010006725 active site 1201010006726 urocanate hydratase; Provisional; Region: PRK05414 1201010006727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1201010006728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1201010006729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1201010006730 dimerization interface [polypeptide binding]; other site 1201010006731 formimidoylglutamase; Provisional; Region: PRK13775 1201010006732 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1201010006733 putative active site [active] 1201010006734 putative metal binding site [ion binding]; other site 1201010006735 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1201010006736 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1201010006737 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1201010006738 active site 1201010006739 dimer interface [polypeptide binding]; other site 1201010006740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1201010006741 MOSC domain; Region: MOSC; pfam03473 1201010006742 3-alpha domain; Region: 3-alpha; pfam03475 1201010006743 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1201010006744 active site 1201010006745 catalytic residues [active] 1201010006746 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1201010006747 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1201010006748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010006749 Walker A/P-loop; other site 1201010006750 ATP binding site [chemical binding]; other site 1201010006751 Q-loop/lid; other site 1201010006752 ABC transporter signature motif; other site 1201010006753 Walker B; other site 1201010006754 D-loop; other site 1201010006755 H-loop/switch region; other site 1201010006756 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1201010006757 Predicted membrane protein [Function unknown]; Region: COG3152 1201010006758 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1201010006759 active site 1201010006760 DNA binding site [nucleotide binding] 1201010006761 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1201010006762 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1201010006763 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1201010006764 homotetramer interface [polypeptide binding]; other site 1201010006765 FMN binding site [chemical binding]; other site 1201010006766 homodimer contacts [polypeptide binding]; other site 1201010006767 putative active site [active] 1201010006768 putative substrate binding site [chemical binding]; other site 1201010006769 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1201010006770 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1201010006771 oligomer interface [polypeptide binding]; other site 1201010006772 metal binding site [ion binding]; metal-binding site 1201010006773 metal binding site [ion binding]; metal-binding site 1201010006774 putative Cl binding site [ion binding]; other site 1201010006775 aspartate ring; other site 1201010006776 basic sphincter; other site 1201010006777 hydrophobic gate; other site 1201010006778 periplasmic entrance; other site 1201010006779 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1201010006780 active site 1201010006781 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1201010006782 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1201010006783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006784 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1201010006785 putative substrate translocation pore; other site 1201010006786 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1201010006787 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1201010006788 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1201010006789 HlyD family secretion protein; Region: HlyD_3; pfam13437 1201010006790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1201010006791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010006792 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1201010006793 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010006794 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1201010006795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006796 putative substrate translocation pore; other site 1201010006797 Predicted membrane protein [Function unknown]; Region: COG4640 1201010006798 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1201010006799 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1201010006800 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1201010006801 putative Zn2+ binding site [ion binding]; other site 1201010006802 putative DNA binding site [nucleotide binding]; other site 1201010006803 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1201010006804 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1201010006805 putative active site [active] 1201010006806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1201010006807 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1201010006808 Walker A/P-loop; other site 1201010006809 ATP binding site [chemical binding]; other site 1201010006810 Q-loop/lid; other site 1201010006811 ABC transporter signature motif; other site 1201010006812 Walker B; other site 1201010006813 D-loop; other site 1201010006814 H-loop/switch region; other site 1201010006815 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1201010006816 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1201010006817 FtsX-like permease family; Region: FtsX; pfam02687 1201010006818 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1201010006819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010006820 active site 1201010006821 phosphorylation site [posttranslational modification] 1201010006822 intermolecular recognition site; other site 1201010006823 dimerization interface [polypeptide binding]; other site 1201010006824 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1201010006825 DNA binding site [nucleotide binding] 1201010006826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1201010006827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1201010006828 dimerization interface [polypeptide binding]; other site 1201010006829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1201010006830 dimer interface [polypeptide binding]; other site 1201010006831 phosphorylation site [posttranslational modification] 1201010006832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010006833 ATP binding site [chemical binding]; other site 1201010006834 Mg2+ binding site [ion binding]; other site 1201010006835 G-X-G motif; other site 1201010006836 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1201010006837 LytTr DNA-binding domain; Region: LytTR; smart00850 1201010006838 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1201010006839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1201010006840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1201010006841 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1201010006842 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1201010006843 Walker A/P-loop; other site 1201010006844 ATP binding site [chemical binding]; other site 1201010006845 Q-loop/lid; other site 1201010006846 ABC transporter signature motif; other site 1201010006847 Walker B; other site 1201010006848 D-loop; other site 1201010006849 H-loop/switch region; other site 1201010006850 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1201010006851 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1201010006852 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 1201010006853 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1201010006854 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1201010006855 L-lactate permease; Region: Lactate_perm; cl00701 1201010006856 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1201010006857 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1201010006858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010006859 Coenzyme A binding pocket [chemical binding]; other site 1201010006860 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1201010006861 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1201010006862 NAD(P) binding site [chemical binding]; other site 1201010006863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010006864 Coenzyme A binding pocket [chemical binding]; other site 1201010006865 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1201010006866 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1201010006867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010006868 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1201010006869 Predicted membrane protein [Function unknown]; Region: COG1511 1201010006870 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1201010006871 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1201010006872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1201010006873 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1201010006874 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1201010006875 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1201010006876 Cl binding site [ion binding]; other site 1201010006877 oligomer interface [polypeptide binding]; other site 1201010006878 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1201010006879 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1201010006880 active site turn [active] 1201010006881 phosphorylation site [posttranslational modification] 1201010006882 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1201010006883 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1201010006884 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1201010006885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1201010006886 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1201010006887 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1201010006888 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1201010006889 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1201010006890 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1201010006891 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1201010006892 MarR family; Region: MarR_2; pfam12802 1201010006893 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1201010006894 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1201010006895 putative dimer interface [polypeptide binding]; other site 1201010006896 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1201010006897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006898 putative substrate translocation pore; other site 1201010006899 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1201010006900 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1201010006901 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1201010006902 DNA binding residues [nucleotide binding] 1201010006903 dimer interface [polypeptide binding]; other site 1201010006904 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1201010006905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1201010006906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010006907 active site 1201010006908 phosphorylation site [posttranslational modification] 1201010006909 intermolecular recognition site; other site 1201010006910 dimerization interface [polypeptide binding]; other site 1201010006911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1201010006912 DNA binding residues [nucleotide binding] 1201010006913 dimerization interface [polypeptide binding]; other site 1201010006914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1201010006915 Histidine kinase; Region: HisKA_3; pfam07730 1201010006916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010006917 ATP binding site [chemical binding]; other site 1201010006918 Mg2+ binding site [ion binding]; other site 1201010006919 G-X-G motif; other site 1201010006920 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1201010006921 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1201010006922 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1201010006923 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1201010006924 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1201010006925 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1201010006926 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1201010006927 [4Fe-4S] binding site [ion binding]; other site 1201010006928 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1201010006929 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1201010006930 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1201010006931 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1201010006932 molybdopterin cofactor binding site; other site 1201010006933 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1201010006934 active site 1201010006935 SAM binding site [chemical binding]; other site 1201010006936 homodimer interface [polypeptide binding]; other site 1201010006937 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1201010006938 [2Fe-2S] cluster binding site [ion binding]; other site 1201010006939 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1201010006940 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1201010006941 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1201010006942 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1201010006943 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1201010006944 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1201010006945 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1201010006946 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1201010006947 putative active site [active] 1201010006948 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1201010006949 active site 1201010006950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1201010006951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010006952 Coenzyme A binding pocket [chemical binding]; other site 1201010006953 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1201010006954 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1201010006955 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1201010006956 putative hydrophobic ligand binding site [chemical binding]; other site 1201010006957 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1201010006958 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1201010006959 intersubunit interface [polypeptide binding]; other site 1201010006960 YodA lipocalin-like domain; Region: YodA; pfam09223 1201010006961 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1201010006962 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1201010006963 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1201010006964 Thioredoxin; Region: Thioredoxin_4; cl17273 1201010006965 FemAB family; Region: FemAB; pfam02388 1201010006966 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1201010006967 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1201010006968 Walker A/P-loop; other site 1201010006969 ATP binding site [chemical binding]; other site 1201010006970 Q-loop/lid; other site 1201010006971 ABC transporter signature motif; other site 1201010006972 Walker B; other site 1201010006973 D-loop; other site 1201010006974 H-loop/switch region; other site 1201010006975 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1201010006976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010006977 dimer interface [polypeptide binding]; other site 1201010006978 conserved gate region; other site 1201010006979 putative PBP binding loops; other site 1201010006980 ABC-ATPase subunit interface; other site 1201010006981 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1201010006982 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1201010006983 substrate binding pocket [chemical binding]; other site 1201010006984 membrane-bound complex binding site; other site 1201010006985 hinge residues; other site 1201010006986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010006988 putative substrate translocation pore; other site 1201010006989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010006990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1201010006991 catalytic core [active] 1201010006992 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1201010006993 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1201010006994 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1201010006995 B domain; Region: B; pfam02216 1201010006996 B domain; Region: B; pfam02216 1201010006997 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 1201010006998 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1201010006999 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1201010007000 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1201010007001 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1201010007002 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1201010007003 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1201010007004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1201010007005 catalytic residue [active] 1201010007006 biotin synthase; Validated; Region: PRK06256 1201010007007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010007008 FeS/SAM binding site; other site 1201010007009 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1201010007010 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1201010007011 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1201010007012 inhibitor-cofactor binding pocket; inhibition site 1201010007013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010007014 catalytic residue [active] 1201010007015 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1201010007016 AAA domain; Region: AAA_26; pfam13500 1201010007017 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1201010007018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1201010007019 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1201010007020 Walker A/P-loop; other site 1201010007021 ATP binding site [chemical binding]; other site 1201010007022 Q-loop/lid; other site 1201010007023 ABC transporter signature motif; other site 1201010007024 Walker B; other site 1201010007025 D-loop; other site 1201010007026 H-loop/switch region; other site 1201010007027 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1201010007028 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1201010007029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010007030 Walker A/P-loop; other site 1201010007031 ATP binding site [chemical binding]; other site 1201010007032 Q-loop/lid; other site 1201010007033 ABC transporter signature motif; other site 1201010007034 Walker B; other site 1201010007035 D-loop; other site 1201010007036 H-loop/switch region; other site 1201010007037 Predicted membrane protein [Function unknown]; Region: COG2246 1201010007038 GtrA-like protein; Region: GtrA; pfam04138 1201010007039 glycerate kinase; Region: TIGR00045 1201010007040 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1201010007041 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1201010007042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010007043 putative substrate translocation pore; other site 1201010007044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1201010007045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1201010007046 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1201010007047 putative phosphoesterase; Region: acc_ester; TIGR03729 1201010007048 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1201010007049 Spore germination protein; Region: Spore_permease; cl17796 1201010007050 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1201010007051 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1201010007052 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1201010007053 Beta-lactamase; Region: Beta-lactamase; pfam00144 1201010007054 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1201010007055 extended (e) SDRs; Region: SDR_e; cd08946 1201010007056 NAD(P) binding site [chemical binding]; other site 1201010007057 active site 1201010007058 substrate binding site [chemical binding]; other site 1201010007059 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1201010007060 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1201010007061 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1201010007062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010007063 putative substrate translocation pore; other site 1201010007064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010007065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010007066 dimer interface [polypeptide binding]; other site 1201010007067 conserved gate region; other site 1201010007068 ABC-ATPase subunit interface; other site 1201010007069 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1201010007070 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1201010007071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010007072 dimer interface [polypeptide binding]; other site 1201010007073 conserved gate region; other site 1201010007074 putative PBP binding loops; other site 1201010007075 ABC-ATPase subunit interface; other site 1201010007076 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1201010007077 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1201010007078 Walker A/P-loop; other site 1201010007079 ATP binding site [chemical binding]; other site 1201010007080 Q-loop/lid; other site 1201010007081 ABC transporter signature motif; other site 1201010007082 Walker B; other site 1201010007083 D-loop; other site 1201010007084 H-loop/switch region; other site 1201010007085 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1201010007086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1201010007087 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1201010007088 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1201010007089 amino acid transporter; Region: 2A0306; TIGR00909 1201010007090 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1201010007091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1201010007092 substrate binding pocket [chemical binding]; other site 1201010007093 catalytic triad [active] 1201010007094 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1201010007095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010007096 putative substrate translocation pore; other site 1201010007097 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1201010007098 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1201010007099 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1201010007100 Walker A/P-loop; other site 1201010007101 ATP binding site [chemical binding]; other site 1201010007102 Q-loop/lid; other site 1201010007103 ABC transporter signature motif; other site 1201010007104 Walker B; other site 1201010007105 D-loop; other site 1201010007106 H-loop/switch region; other site 1201010007107 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1201010007108 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1201010007109 oligomer interface [polypeptide binding]; other site 1201010007110 active site 1201010007111 metal binding site [ion binding]; metal-binding site 1201010007112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1201010007113 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1201010007114 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1201010007115 active site 1201010007116 FMN binding site [chemical binding]; other site 1201010007117 substrate binding site [chemical binding]; other site 1201010007118 3Fe-4S cluster binding site [ion binding]; other site 1201010007119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010007120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1201010007121 putative substrate translocation pore; other site 1201010007122 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1201010007123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010007124 Walker A/P-loop; other site 1201010007125 ATP binding site [chemical binding]; other site 1201010007126 Q-loop/lid; other site 1201010007127 ABC transporter signature motif; other site 1201010007128 Walker B; other site 1201010007129 D-loop; other site 1201010007130 H-loop/switch region; other site 1201010007131 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1201010007132 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1201010007133 Walker A/P-loop; other site 1201010007134 ATP binding site [chemical binding]; other site 1201010007135 Q-loop/lid; other site 1201010007136 ABC transporter signature motif; other site 1201010007137 Walker B; other site 1201010007138 D-loop; other site 1201010007139 H-loop/switch region; other site 1201010007140 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1201010007141 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1201010007142 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1201010007143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010007144 dimer interface [polypeptide binding]; other site 1201010007145 conserved gate region; other site 1201010007146 putative PBP binding loops; other site 1201010007147 ABC-ATPase subunit interface; other site 1201010007148 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1201010007149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1201010007150 dimer interface [polypeptide binding]; other site 1201010007151 conserved gate region; other site 1201010007152 putative PBP binding loops; other site 1201010007153 ABC-ATPase subunit interface; other site 1201010007154 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1201010007155 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1201010007156 substrate binding site [chemical binding]; other site 1201010007157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1201010007158 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1201010007159 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1201010007160 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1201010007161 short chain dehydrogenase; Validated; Region: PRK08589 1201010007162 classical (c) SDRs; Region: SDR_c; cd05233 1201010007163 NAD(P) binding site [chemical binding]; other site 1201010007164 active site 1201010007165 AbgT putative transporter family; Region: ABG_transport; cl17431 1201010007166 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1201010007167 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1201010007168 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1201010007169 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1201010007170 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1201010007171 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1201010007172 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1201010007173 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1201010007174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1201010007175 NAD(P) binding site [chemical binding]; other site 1201010007176 active site 1201010007177 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1201010007178 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010007179 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010007180 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010007181 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1201010007182 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1201010007183 PLD-like domain; Region: PLDc_2; pfam13091 1201010007184 putative homodimer interface [polypeptide binding]; other site 1201010007185 putative active site [active] 1201010007186 catalytic site [active] 1201010007187 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1201010007188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1201010007189 ATP binding site [chemical binding]; other site 1201010007190 putative Mg++ binding site [ion binding]; other site 1201010007191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1201010007192 nucleotide binding region [chemical binding]; other site 1201010007193 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1201010007194 ATP-binding site [chemical binding]; other site 1201010007195 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1201010007196 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1201010007197 active site 1201010007198 8-oxo-dGMP binding site [chemical binding]; other site 1201010007199 nudix motif; other site 1201010007200 metal binding site [ion binding]; metal-binding site 1201010007201 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1201010007202 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1201010007203 active site 1201010007204 substrate binding site [chemical binding]; other site 1201010007205 metal binding site [ion binding]; metal-binding site 1201010007206 H+ Antiporter protein; Region: 2A0121; TIGR00900 1201010007207 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010007208 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1201010007209 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010007210 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1201010007211 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1201010007212 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1201010007213 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1201010007214 active site 1201010007215 tetramer interface; other site 1201010007216 GntP family permease; Region: GntP_permease; pfam02447 1201010007217 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1201010007218 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1201010007219 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1201010007220 N- and C-terminal domain interface [polypeptide binding]; other site 1201010007221 active site 1201010007222 catalytic site [active] 1201010007223 metal binding site [ion binding]; metal-binding site 1201010007224 carbohydrate binding site [chemical binding]; other site 1201010007225 ATP binding site [chemical binding]; other site 1201010007226 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1201010007227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1201010007228 DNA-binding site [nucleotide binding]; DNA binding site 1201010007229 FCD domain; Region: FCD; pfam07729 1201010007230 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1201010007231 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1201010007232 DNA binding residues [nucleotide binding] 1201010007233 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1201010007234 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1201010007235 synthetase active site [active] 1201010007236 NTP binding site [chemical binding]; other site 1201010007237 metal binding site [ion binding]; metal-binding site 1201010007238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1201010007239 Predicted membrane protein [Function unknown]; Region: COG1289 1201010007240 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1201010007241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1201010007242 D-galactonate transporter; Region: 2A0114; TIGR00893 1201010007243 putative substrate translocation pore; other site 1201010007244 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1201010007245 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1201010007246 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1201010007247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010007248 Walker A/P-loop; other site 1201010007249 ATP binding site [chemical binding]; other site 1201010007250 Q-loop/lid; other site 1201010007251 ABC transporter signature motif; other site 1201010007252 Walker B; other site 1201010007253 D-loop; other site 1201010007254 H-loop/switch region; other site 1201010007255 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1201010007256 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1201010007257 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1201010007258 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1201010007259 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1201010007260 putative NAD(P) binding site [chemical binding]; other site 1201010007261 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1201010007262 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1201010007263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1201010007264 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1201010007265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1201010007266 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010007267 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1201010007268 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1201010007269 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1201010007270 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1201010007271 Predicted esterase [General function prediction only]; Region: COG0400 1201010007272 putative hydrolase; Provisional; Region: PRK11460 1201010007273 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1201010007274 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1201010007275 Zn binding site [ion binding]; other site 1201010007276 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1201010007277 Zn binding site [ion binding]; other site 1201010007278 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1201010007279 MarR family; Region: MarR; pfam01047 1201010007280 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1201010007281 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1201010007282 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1201010007283 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1201010007284 putative metal binding site [ion binding]; other site 1201010007285 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1201010007286 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1201010007287 dimer interface [polypeptide binding]; other site 1201010007288 FMN binding site [chemical binding]; other site 1201010007289 D-lactate dehydrogenase; Provisional; Region: PRK12480 1201010007290 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1201010007291 homodimer interface [polypeptide binding]; other site 1201010007292 ligand binding site [chemical binding]; other site 1201010007293 NAD binding site [chemical binding]; other site 1201010007294 catalytic site [active] 1201010007295 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1201010007296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1201010007297 active site 1201010007298 motif I; other site 1201010007299 motif II; other site 1201010007300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1201010007301 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1201010007302 Walker A/P-loop; other site 1201010007303 ATP binding site [chemical binding]; other site 1201010007304 Q-loop/lid; other site 1201010007305 ABC transporter signature motif; other site 1201010007306 Walker B; other site 1201010007307 D-loop; other site 1201010007308 H-loop/switch region; other site 1201010007309 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1201010007310 active site 1201010007311 catalytic site [active] 1201010007312 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1201010007313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010007314 Coenzyme A binding pocket [chemical binding]; other site 1201010007315 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1201010007316 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1201010007317 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1201010007318 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1201010007319 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1201010007320 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1201010007321 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1201010007322 EamA-like transporter family; Region: EamA; pfam00892 1201010007323 EamA-like transporter family; Region: EamA; pfam00892 1201010007324 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1201010007325 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1201010007326 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1201010007327 catalytic residues [active] 1201010007328 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1201010007329 active site 1201010007330 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1201010007331 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1201010007332 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1201010007333 active site turn [active] 1201010007334 phosphorylation site [posttranslational modification] 1201010007335 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1201010007336 HPr interaction site; other site 1201010007337 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1201010007338 active site 1201010007339 phosphorylation site [posttranslational modification] 1201010007340 pyruvate oxidase; Provisional; Region: PRK08611 1201010007341 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1201010007342 PYR/PP interface [polypeptide binding]; other site 1201010007343 tetramer interface [polypeptide binding]; other site 1201010007344 dimer interface [polypeptide binding]; other site 1201010007345 TPP binding site [chemical binding]; other site 1201010007346 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1201010007347 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1201010007348 TPP-binding site [chemical binding]; other site 1201010007349 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1201010007350 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1201010007351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1201010007352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1201010007353 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1201010007354 putative dimerization interface [polypeptide binding]; other site 1201010007355 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1201010007356 Surface antigen [General function prediction only]; Region: COG3942 1201010007357 CHAP domain; Region: CHAP; pfam05257 1201010007358 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1201010007359 homodimer interface [polypeptide binding]; other site 1201010007360 catalytic residues [active] 1201010007361 NAD binding site [chemical binding]; other site 1201010007362 substrate binding pocket [chemical binding]; other site 1201010007363 flexible flap; other site 1201010007364 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1201010007365 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1201010007366 dimer interface [polypeptide binding]; other site 1201010007367 active site 1201010007368 superantigen-like protein; Reviewed; Region: PRK13037 1201010007369 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1201010007370 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1201010007371 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1201010007372 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1201010007373 DNA binding site [nucleotide binding] 1201010007374 active site 1201010007375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010007376 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1201010007377 Walker A motif; other site 1201010007378 ATP binding site [chemical binding]; other site 1201010007379 Walker B motif; other site 1201010007380 arginine finger; other site 1201010007381 UvrB/uvrC motif; Region: UVR; pfam02151 1201010007382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1201010007383 Walker A motif; other site 1201010007384 ATP binding site [chemical binding]; other site 1201010007385 Walker B motif; other site 1201010007386 arginine finger; other site 1201010007387 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1201010007388 Virus attachment protein p12 family; Region: P12; pfam12669 1201010007389 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1201010007390 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1201010007391 G1 box; other site 1201010007392 GTP/Mg2+ binding site [chemical binding]; other site 1201010007393 Switch I region; other site 1201010007394 G2 box; other site 1201010007395 G3 box; other site 1201010007396 Switch II region; other site 1201010007397 G4 box; other site 1201010007398 G5 box; other site 1201010007399 Nucleoside recognition; Region: Gate; pfam07670 1201010007400 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1201010007401 Nucleoside recognition; Region: Gate; pfam07670 1201010007402 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1201010007403 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1201010007404 Protein export membrane protein; Region: SecD_SecF; cl14618 1201010007405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1201010007406 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1201010007407 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1201010007408 Glutamate binding site [chemical binding]; other site 1201010007409 homodimer interface [polypeptide binding]; other site 1201010007410 NAD binding site [chemical binding]; other site 1201010007411 catalytic residues [active] 1201010007412 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1201010007413 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1201010007414 active site 1201010007415 substrate binding site [chemical binding]; other site 1201010007416 trimer interface [polypeptide binding]; other site 1201010007417 CoA binding site [chemical binding]; other site 1201010007418 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1201010007419 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1201010007420 metal-binding site [ion binding] 1201010007421 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1201010007422 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1201010007423 metal-binding site [ion binding] 1201010007424 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1201010007425 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1201010007426 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1201010007427 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1201010007428 metal-binding site [ion binding] 1201010007429 D-lactate dehydrogenase; Validated; Region: PRK08605 1201010007430 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1201010007431 homodimer interface [polypeptide binding]; other site 1201010007432 ligand binding site [chemical binding]; other site 1201010007433 NAD binding site [chemical binding]; other site 1201010007434 catalytic site [active] 1201010007435 transaminase; Reviewed; Region: PRK08068 1201010007436 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1201010007437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010007438 homodimer interface [polypeptide binding]; other site 1201010007439 catalytic residue [active] 1201010007440 phytoene desaturase; Region: crtI_fam; TIGR02734 1201010007441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1201010007442 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1201010007443 active site lid residues [active] 1201010007444 substrate binding pocket [chemical binding]; other site 1201010007445 catalytic residues [active] 1201010007446 substrate-Mg2+ binding site; other site 1201010007447 aspartate-rich region 1; other site 1201010007448 aspartate-rich region 2; other site 1201010007449 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1201010007450 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1201010007451 active site 1201010007452 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1201010007453 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1201010007454 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 1201010007455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1201010007456 Surface antigen [General function prediction only]; Region: COG3942 1201010007457 CHAP domain; Region: CHAP; pfam05257 1201010007458 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1201010007459 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1201010007460 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1201010007461 catalytic triad [active] 1201010007462 catalytic triad [active] 1201010007463 oxyanion hole [active] 1201010007464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010007465 Coenzyme A binding pocket [chemical binding]; other site 1201010007466 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1201010007467 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1201010007468 catalytic residue [active] 1201010007469 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1201010007470 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1201010007471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1201010007472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1201010007473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1201010007474 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1201010007475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1201010007476 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1201010007477 NmrA-like family; Region: NmrA; pfam05368 1201010007478 NADP binding site [chemical binding]; other site 1201010007479 active site 1201010007480 regulatory binding site [polypeptide binding]; other site 1201010007481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 1201010007482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1201010007483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1201010007484 short chain dehydrogenase; Provisional; Region: PRK12937 1201010007485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1201010007486 NAD(P) binding site [chemical binding]; other site 1201010007487 active site 1201010007488 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1201010007489 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1201010007490 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1201010007491 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1201010007492 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1201010007493 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1201010007494 Nucleoside recognition; Region: Gate; pfam07670 1201010007495 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1201010007496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1201010007497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 1201010007498 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 1201010007499 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1201010007500 Phosphotransferase enzyme family; Region: APH; pfam01636 1201010007501 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1201010007502 active site 1201010007503 ATP binding site [chemical binding]; other site 1201010007504 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1201010007505 active site 1201010007506 ATP binding site [chemical binding]; other site 1201010007507 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1201010007508 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1201010007509 quinone interaction residues [chemical binding]; other site 1201010007510 active site 1201010007511 catalytic residues [active] 1201010007512 FMN binding site [chemical binding]; other site 1201010007513 substrate binding site [chemical binding]; other site 1201010007514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1201010007515 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1201010007516 dimer interface [polypeptide binding]; other site 1201010007517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1201010007518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1201010007519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1201010007520 Predicted acyl esterases [General function prediction only]; Region: COG2936 1201010007521 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1201010007522 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1201010007523 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1201010007524 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1201010007525 tetramerization interface [polypeptide binding]; other site 1201010007526 active site 1201010007527 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1201010007528 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1201010007529 active site 1201010007530 ATP-binding site [chemical binding]; other site 1201010007531 pantoate-binding site; other site 1201010007532 HXXH motif; other site 1201010007533 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1201010007534 oligomerization interface [polypeptide binding]; other site 1201010007535 active site 1201010007536 metal binding site [ion binding]; metal-binding site 1201010007537 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1201010007538 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1201010007539 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1201010007540 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1201010007541 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1201010007542 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1201010007543 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1201010007544 NAD binding site [chemical binding]; other site 1201010007545 dimer interface [polypeptide binding]; other site 1201010007546 substrate binding site [chemical binding]; other site 1201010007547 amino acid transporter; Region: 2A0306; TIGR00909 1201010007548 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1201010007549 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1201010007550 inhibitor-cofactor binding pocket; inhibition site 1201010007551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010007552 catalytic residue [active] 1201010007553 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1201010007554 catalytic residue [active] 1201010007555 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1201010007556 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1201010007557 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1201010007558 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1201010007559 acyl-activating enzyme (AAE) consensus motif; other site 1201010007560 AMP binding site [chemical binding]; other site 1201010007561 active site 1201010007562 CoA binding site [chemical binding]; other site 1201010007563 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1201010007564 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1201010007565 choline dehydrogenase; Validated; Region: PRK02106 1201010007566 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1201010007567 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1201010007568 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1201010007569 tetramerization interface [polypeptide binding]; other site 1201010007570 NAD(P) binding site [chemical binding]; other site 1201010007571 catalytic residues [active] 1201010007572 Predicted transcriptional regulators [Transcription]; Region: COG1510 1201010007573 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1201010007574 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1201010007575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1201010007576 FeS/SAM binding site; other site 1201010007577 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1201010007578 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1201010007579 effector binding site; other site 1201010007580 active site 1201010007581 Zn binding site [ion binding]; other site 1201010007582 glycine loop; other site 1201010007583 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1201010007584 Citrate transporter; Region: CitMHS; pfam03600 1201010007585 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1201010007586 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1201010007587 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1201010007588 Flavodoxin; Region: Flavodoxin_1; pfam00258 1201010007589 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1201010007590 FAD binding pocket [chemical binding]; other site 1201010007591 FAD binding motif [chemical binding]; other site 1201010007592 catalytic residues [active] 1201010007593 NAD binding pocket [chemical binding]; other site 1201010007594 phosphate binding motif [ion binding]; other site 1201010007595 beta-alpha-beta structure motif; other site 1201010007596 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1201010007597 catalytic residues [active] 1201010007598 dimer interface [polypeptide binding]; other site 1201010007599 FtsX-like permease family; Region: FtsX; pfam02687 1201010007600 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1201010007601 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1201010007602 Walker A/P-loop; other site 1201010007603 ATP binding site [chemical binding]; other site 1201010007604 Q-loop/lid; other site 1201010007605 ABC transporter signature motif; other site 1201010007606 Walker B; other site 1201010007607 D-loop; other site 1201010007608 H-loop/switch region; other site 1201010007609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1201010007610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1201010007611 ATP binding site [chemical binding]; other site 1201010007612 Mg2+ binding site [ion binding]; other site 1201010007613 G-X-G motif; other site 1201010007614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1201010007615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1201010007616 active site 1201010007617 phosphorylation site [posttranslational modification] 1201010007618 intermolecular recognition site; other site 1201010007619 dimerization interface [polypeptide binding]; other site 1201010007620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1201010007621 DNA binding site [nucleotide binding] 1201010007622 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1201010007623 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1201010007624 dimer interface [polypeptide binding]; other site 1201010007625 active site 1201010007626 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1201010007627 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1201010007628 MarR family; Region: MarR_2; pfam12802 1201010007629 Predicted esterase [General function prediction only]; Region: COG0627 1201010007630 S-formylglutathione hydrolase; Region: PLN02442 1201010007631 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1201010007632 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1201010007633 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1201010007634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1201010007635 ligand binding site [chemical binding]; other site 1201010007636 flexible hinge region; other site 1201010007637 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1201010007638 carbamate kinase; Reviewed; Region: PRK12686 1201010007639 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1201010007640 putative substrate binding site [chemical binding]; other site 1201010007641 nucleotide binding site [chemical binding]; other site 1201010007642 nucleotide binding site [chemical binding]; other site 1201010007643 homodimer interface [polypeptide binding]; other site 1201010007644 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1201010007645 ornithine carbamoyltransferase; Validated; Region: PRK02102 1201010007646 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1201010007647 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1201010007648 arginine deiminase; Provisional; Region: PRK01388 1201010007649 Arginine repressor [Transcription]; Region: ArgR; COG1438 1201010007650 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1201010007651 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1201010007652 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1201010007653 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1201010007654 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1201010007655 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1201010007656 active site 1201010007657 Zn binding site [ion binding]; other site 1201010007658 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1201010007659 HTH domain; Region: HTH_11; pfam08279 1201010007660 PRD domain; Region: PRD; pfam00874 1201010007661 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1201010007662 active site 1201010007663 P-loop; other site 1201010007664 phosphorylation site [posttranslational modification] 1201010007665 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1201010007666 active site 1201010007667 phosphorylation site [posttranslational modification] 1201010007668 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1201010007669 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1201010007670 active site 1201010007671 P-loop; other site 1201010007672 phosphorylation site [posttranslational modification] 1201010007673 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1201010007674 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1201010007675 active site 1201010007676 phosphorylation site [posttranslational modification] 1201010007677 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1201010007678 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1201010007679 Predicted membrane protein [Function unknown]; Region: COG1511 1201010007680 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1201010007681 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1201010007682 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1201010007683 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1201010007684 CHAP domain; Region: CHAP; pfam05257 1201010007685 Isochorismatase family; Region: Isochorismatase; pfam00857 1201010007686 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1201010007687 catalytic triad [active] 1201010007688 conserved cis-peptide bond; other site 1201010007689 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1201010007690 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1201010007691 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1201010007692 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1201010007693 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1201010007694 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1201010007695 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1201010007696 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1201010007697 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1201010007698 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1201010007699 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1201010007700 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1201010007701 SecY translocase; Region: SecY; pfam00344 1201010007702 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1201010007703 legume lectins; Region: lectin_L-type; cd01951 1201010007704 homotetramer interaction site [polypeptide binding]; other site 1201010007705 carbohydrate binding site [chemical binding]; other site 1201010007706 metal binding site [ion binding]; metal-binding site 1201010007707 Putative Ig domain; Region: He_PIG; pfam05345 1201010007708 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1201010007709 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1201010007710 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1201010007711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1201010007712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1201010007713 Coenzyme A binding pocket [chemical binding]; other site 1201010007714 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1201010007715 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1201010007716 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1201010007717 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1201010007718 Chain length determinant protein; Region: Wzz; cl15801 1201010007719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1201010007720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1201010007721 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1201010007722 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1201010007723 DXD motif; other site 1201010007724 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 1201010007725 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 1201010007726 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1201010007727 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1201010007728 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1201010007729 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1201010007730 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1201010007731 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1201010007732 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1201010007733 metal binding site [ion binding]; metal-binding site 1201010007734 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1201010007735 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1201010007736 substrate binding site [chemical binding]; other site 1201010007737 glutamase interaction surface [polypeptide binding]; other site 1201010007738 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1201010007739 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1201010007740 catalytic residues [active] 1201010007741 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1201010007742 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1201010007743 putative active site [active] 1201010007744 oxyanion strand; other site 1201010007745 catalytic triad [active] 1201010007746 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1201010007747 putative active site pocket [active] 1201010007748 4-fold oligomerization interface [polypeptide binding]; other site 1201010007749 metal binding residues [ion binding]; metal-binding site 1201010007750 3-fold/trimer interface [polypeptide binding]; other site 1201010007751 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1201010007752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1201010007753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1201010007754 homodimer interface [polypeptide binding]; other site 1201010007755 catalytic residue [active] 1201010007756 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1201010007757 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1201010007758 NAD binding site [chemical binding]; other site 1201010007759 dimerization interface [polypeptide binding]; other site 1201010007760 product binding site; other site 1201010007761 substrate binding site [chemical binding]; other site 1201010007762 zinc binding site [ion binding]; other site 1201010007763 catalytic residues [active] 1201010007764 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 1201010007765 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1201010007766 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1201010007767 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1201010007768 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1201010007769 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1201010007770 putative active site [active] 1201010007771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1201010007772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1201010007773 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1201010007774 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1201010007775 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1201010007776 Walker A/P-loop; other site 1201010007777 ATP binding site [chemical binding]; other site 1201010007778 Q-loop/lid; other site 1201010007779 ABC transporter signature motif; other site 1201010007780 Walker B; other site 1201010007781 D-loop; other site 1201010007782 H-loop/switch region; other site 1201010007783 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1201010007784 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1201010007785 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1201010007786 Walker A/P-loop; other site 1201010007787 ATP binding site [chemical binding]; other site 1201010007788 Q-loop/lid; other site 1201010007789 ABC transporter signature motif; other site 1201010007790 Walker B; other site 1201010007791 D-loop; other site 1201010007792 H-loop/switch region; other site 1201010007793 hypothetical protein; Provisional; Region: PRK13661 1201010007794 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1201010007795 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1201010007796 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1201010007797 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1201010007798 Strictosidine synthase; Region: Str_synth; pfam03088 1201010007799 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1201010007800 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1201010007801 active site residue [active] 1201010007802 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1201010007803 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1201010007804 putative substrate binding pocket [chemical binding]; other site 1201010007805 AC domain interface; other site 1201010007806 catalytic triad [active] 1201010007807 AB domain interface; other site 1201010007808 interchain disulfide; other site 1201010007809 hypothetical protein; Validated; Region: PRK07668 1201010007810 Predicted transcriptional regulators [Transcription]; Region: COG1695 1201010007811 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1201010007812 DinB superfamily; Region: DinB_2; pfam12867 1201010007813 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1201010007814 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1201010007815 transmembrane helices; other site 1201010007816 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1201010007817 EamA-like transporter family; Region: EamA; pfam00892 1201010007818 hypothetical protein; Provisional; Region: PRK07758 1201010007819 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1201010007820 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1201010007821 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1201010007822 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1201010007823 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1201010007824 Walker A/P-loop; other site 1201010007825 ATP binding site [chemical binding]; other site 1201010007826 Q-loop/lid; other site 1201010007827 ABC transporter signature motif; other site 1201010007828 Walker B; other site 1201010007829 D-loop; other site 1201010007830 H-loop/switch region; other site 1201010007831 FtsX-like permease family; Region: FtsX; pfam02687 1201010007832 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1201010007833 Integrase core domain; Region: rve; pfam00665 1201010007834 Integrase core domain; Region: rve_3; cl15866 1201010007835 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1201010007836 Integrase core domain; Region: rve; pfam00665 1201010007837 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1201010007838 DNA-binding site [nucleotide binding]; DNA binding site 1201010007839 RNA-binding motif; other site 1201010007840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1201010007841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1201010007842 non-specific DNA binding site [nucleotide binding]; other site 1201010007843 salt bridge; other site 1201010007844 sequence-specific DNA binding site [nucleotide binding]; other site 1201010007845 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1201010007846 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1201010007847 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1201010007848 ParB-like nuclease domain; Region: ParBc; pfam02195 1201010007849 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1201010007850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1201010007851 S-adenosylmethionine binding site [chemical binding]; other site 1201010007852 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1201010007853 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1201010007854 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1201010007855 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1201010007856 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1201010007857 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1201010007858 G1 box; other site 1201010007859 GTP/Mg2+ binding site [chemical binding]; other site 1201010007860 Switch I region; other site 1201010007861 G2 box; other site 1201010007862 Switch II region; other site 1201010007863 G3 box; other site 1201010007864 G4 box; other site 1201010007865 G5 box; other site 1201010007866 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1201010007867 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1201010007868 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399