-- dump date   	20140620_075016
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1074919000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1074919000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1074919000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919000004	Walker A motif; other site
1074919000005	ATP binding site [chemical binding]; other site
1074919000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1074919000007	Walker B motif; other site
1074919000008	arginine finger; other site
1074919000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1074919000010	DnaA box-binding interface [nucleotide binding]; other site
1074919000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
1074919000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1074919000013	putative DNA binding surface [nucleotide binding]; other site
1074919000014	dimer interface [polypeptide binding]; other site
1074919000015	beta-clamp/clamp loader binding surface; other site
1074919000016	beta-clamp/translesion DNA polymerase binding surface; other site
1074919000017	recF protein; Region: recf; TIGR00611
1074919000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1074919000019	Walker A/P-loop; other site
1074919000020	ATP binding site [chemical binding]; other site
1074919000021	Q-loop/lid; other site
1074919000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919000023	ABC transporter signature motif; other site
1074919000024	Walker B; other site
1074919000025	D-loop; other site
1074919000026	H-loop/switch region; other site
1074919000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1074919000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919000029	Mg2+ binding site [ion binding]; other site
1074919000030	G-X-G motif; other site
1074919000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1074919000032	anchoring element; other site
1074919000033	dimer interface [polypeptide binding]; other site
1074919000034	ATP binding site [chemical binding]; other site
1074919000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1074919000036	active site
1074919000037	putative metal-binding site [ion binding]; other site
1074919000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1074919000039	DNA gyrase subunit A; Validated; Region: PRK05560
1074919000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1074919000041	CAP-like domain; other site
1074919000042	active site
1074919000043	primary dimer interface [polypeptide binding]; other site
1074919000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000050	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1074919000051	putative substrate binding site [chemical binding]; other site
1074919000052	putative ATP binding site [chemical binding]; other site
1074919000053	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1074919000054	active sites [active]
1074919000055	tetramer interface [polypeptide binding]; other site
1074919000056	seryl-tRNA synthetase; Provisional; Region: PRK05431
1074919000057	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1074919000058	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1074919000059	dimer interface [polypeptide binding]; other site
1074919000060	active site
1074919000061	motif 1; other site
1074919000062	motif 2; other site
1074919000063	motif 3; other site
1074919000064	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1074919000065	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1074919000066	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1074919000067	Predicted membrane protein [Function unknown]; Region: COG4241
1074919000068	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1074919000069	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1074919000070	DHH family; Region: DHH; pfam01368
1074919000071	DHHA1 domain; Region: DHHA1; pfam02272
1074919000072	replicative DNA helicase; Region: DnaB; TIGR00665
1074919000073	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1074919000074	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1074919000075	Walker A motif; other site
1074919000076	ATP binding site [chemical binding]; other site
1074919000077	Walker B motif; other site
1074919000078	DNA binding loops [nucleotide binding]
1074919000079	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1074919000080	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1074919000081	GDP-binding site [chemical binding]; other site
1074919000082	ACT binding site; other site
1074919000083	IMP binding site; other site
1074919000084	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919000085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919000086	active site
1074919000087	phosphorylation site [posttranslational modification]
1074919000088	intermolecular recognition site; other site
1074919000089	dimerization interface [polypeptide binding]; other site
1074919000090	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919000091	DNA binding site [nucleotide binding]
1074919000092	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1074919000093	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074919000094	dimerization interface [polypeptide binding]; other site
1074919000095	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1074919000096	putative active site [active]
1074919000097	heme pocket [chemical binding]; other site
1074919000098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919000099	dimer interface [polypeptide binding]; other site
1074919000100	phosphorylation site [posttranslational modification]
1074919000101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919000102	ATP binding site [chemical binding]; other site
1074919000103	Mg2+ binding site [ion binding]; other site
1074919000104	G-X-G motif; other site
1074919000105	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1074919000106	YycH protein; Region: YycH; pfam07435
1074919000107	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
1074919000108	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1074919000109	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1074919000110	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
1074919000111	putative active site [active]
1074919000112	putative metal binding site [ion binding]; other site
1074919000113	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1074919000114	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1074919000115	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1074919000116	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
1074919000117	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
1074919000118	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919000119	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1074919000120	putative active site [active]
1074919000121	catalytic site [active]
1074919000122	putative metal binding site [ion binding]; other site
1074919000123	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1074919000124	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1074919000125	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1074919000126	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1074919000127	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1074919000128	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1074919000129	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1074919000130	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1074919000131	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1074919000132	Recombinase; Region: Recombinase; pfam07508
1074919000133	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1074919000134	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1074919000135	catalytic residues [active]
1074919000136	catalytic nucleophile [active]
1074919000137	Recombinase; Region: Recombinase; pfam07508
1074919000138	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1074919000139	Domain of unknown function (DUF927); Region: DUF927; pfam06048
1074919000140	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1074919000141	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074919000142	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074919000143	active site residue [active]
1074919000144	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074919000145	active site residue [active]
1074919000146	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
1074919000147	CPxP  motif; other site
1074919000148	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1074919000149	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1074919000150	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1074919000151	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1074919000152	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919000153	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919000154	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
1074919000155	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1074919000156	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074919000157	active site residue [active]
1074919000158	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
1074919000159	CPxP  motif; other site
1074919000160	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1074919000161	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1074919000162	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1074919000163	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074919000164	active site residue [active]
1074919000165	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1074919000166	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1074919000167	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1074919000168	FMN binding site [chemical binding]; other site
1074919000169	active site
1074919000170	catalytic residues [active]
1074919000171	substrate binding site [chemical binding]; other site
1074919000172	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1074919000173	Part of AAA domain; Region: AAA_19; pfam13245
1074919000174	AAA domain; Region: AAA_12; pfam13087
1074919000175	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1074919000176	active site
1074919000177	catalytic site [active]
1074919000178	putative metal binding site [ion binding]; other site
1074919000179	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919000180	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919000181	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919000182	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919000183	Protein of unknown function, DUF576; Region: DUF576; cl04553
1074919000184	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1074919000185	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919000186	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1074919000187	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074919000188	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1074919000189	metal binding site [ion binding]; metal-binding site
1074919000190	dimer interface [polypeptide binding]; other site
1074919000191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000192	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919000193	putative substrate translocation pore; other site
1074919000194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000195	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1074919000196	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1074919000197	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1074919000198	PhoU domain; Region: PhoU; pfam01895
1074919000199	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
1074919000200	EamA-like transporter family; Region: EamA; pfam00892
1074919000201	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1074919000202	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919000203	DNA-binding site [nucleotide binding]; DNA binding site
1074919000204	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919000205	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919000206	homodimer interface [polypeptide binding]; other site
1074919000207	catalytic residue [active]
1074919000208	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1074919000209	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1074919000210	L-lactate permease; Region: Lactate_perm; cl00701
1074919000211	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919000212	B domain; Region: B; pfam02216
1074919000213	B domain; Region: B; pfam02216
1074919000214	B domain; Region: B; pfam02216
1074919000215	B domain; Region: B; pfam02216
1074919000216	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919000217	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919000218	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919000219	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919000220	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919000221	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074919000222	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919000223	ABC-ATPase subunit  interface; other site
1074919000224	dimer interface [polypeptide binding]; other site
1074919000225	putative PBP binding regions; other site
1074919000226	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074919000227	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919000228	ABC-ATPase subunit  interface; other site
1074919000229	dimer interface [polypeptide binding]; other site
1074919000230	putative PBP binding regions; other site
1074919000231	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1074919000232	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1074919000233	siderophore binding site; other site
1074919000234	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
1074919000235	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1074919000236	dimer interface [polypeptide binding]; other site
1074919000237	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919000238	catalytic residue [active]
1074919000239	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
1074919000240	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1074919000241	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919000242	IucA / IucC family; Region: IucA_IucC; pfam04183
1074919000243	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919000244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000245	putative substrate translocation pore; other site
1074919000246	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919000247	IucA / IucC family; Region: IucA_IucC; pfam04183
1074919000248	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919000249	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919000250	IucA / IucC family; Region: IucA_IucC; pfam04183
1074919000251	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919000252	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1074919000253	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1074919000254	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
1074919000255	dimer interface [polypeptide binding]; other site
1074919000256	active site
1074919000257	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919000258	catalytic residues [active]
1074919000259	substrate binding site [chemical binding]; other site
1074919000260	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1074919000261	ParB-like nuclease domain; Region: ParBc; pfam02195
1074919000262	acetoin reductase; Validated; Region: PRK08643
1074919000263	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1074919000264	NAD binding site [chemical binding]; other site
1074919000265	homotetramer interface [polypeptide binding]; other site
1074919000266	homodimer interface [polypeptide binding]; other site
1074919000267	active site
1074919000268	substrate binding site [chemical binding]; other site
1074919000269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919000270	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1074919000271	NAD(P) binding site [chemical binding]; other site
1074919000272	active site
1074919000273	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1074919000274	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1074919000275	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919000276	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1074919000277	putative ADP-binding pocket [chemical binding]; other site
1074919000278	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1074919000279	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1074919000280	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1074919000281	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1074919000282	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1074919000283	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1074919000284	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919000285	DNA-binding site [nucleotide binding]; DNA binding site
1074919000286	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1074919000287	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1074919000288	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919000289	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1074919000290	intersubunit interface [polypeptide binding]; other site
1074919000291	active site
1074919000292	catalytic residue [active]
1074919000293	phosphopentomutase; Provisional; Region: PRK05362
1074919000294	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1074919000295	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1074919000296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000297	dimer interface [polypeptide binding]; other site
1074919000298	conserved gate region; other site
1074919000299	ABC-ATPase subunit interface; other site
1074919000300	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1074919000301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000302	dimer interface [polypeptide binding]; other site
1074919000303	conserved gate region; other site
1074919000304	ABC-ATPase subunit interface; other site
1074919000305	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1074919000306	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1074919000307	Walker A/P-loop; other site
1074919000308	ATP binding site [chemical binding]; other site
1074919000309	Q-loop/lid; other site
1074919000310	ABC transporter signature motif; other site
1074919000311	Walker B; other site
1074919000312	D-loop; other site
1074919000313	H-loop/switch region; other site
1074919000314	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1074919000315	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1074919000316	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1074919000317	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1074919000318	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1074919000319	active site
1074919000320	metal binding site [ion binding]; metal-binding site
1074919000321	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1074919000322	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074919000323	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919000324	non-specific DNA binding site [nucleotide binding]; other site
1074919000325	salt bridge; other site
1074919000326	sequence-specific DNA binding site [nucleotide binding]; other site
1074919000327	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1074919000328	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1074919000329	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1074919000330	putative catalytic cysteine [active]
1074919000331	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1074919000332	putative active site [active]
1074919000333	metal binding site [ion binding]; metal-binding site
1074919000334	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1074919000335	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
1074919000336	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1074919000337	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1074919000338	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1074919000339	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1074919000340	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1074919000341	NAD(P) binding site [chemical binding]; other site
1074919000342	homodimer interface [polypeptide binding]; other site
1074919000343	substrate binding site [chemical binding]; other site
1074919000344	active site
1074919000345	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
1074919000346	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1074919000347	NAD(P) binding site [chemical binding]; other site
1074919000348	homodimer interface [polypeptide binding]; other site
1074919000349	substrate binding site [chemical binding]; other site
1074919000350	active site
1074919000351	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
1074919000352	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
1074919000353	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1074919000354	putative NAD(P) binding site [chemical binding]; other site
1074919000355	active site
1074919000356	putative substrate binding site [chemical binding]; other site
1074919000357	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1074919000358	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1074919000359	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1074919000360	active site
1074919000361	homodimer interface [polypeptide binding]; other site
1074919000362	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1074919000363	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1074919000364	trimer interface [polypeptide binding]; other site
1074919000365	active site
1074919000366	substrate binding site [chemical binding]; other site
1074919000367	CoA binding site [chemical binding]; other site
1074919000368	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919000369	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1074919000370	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1074919000371	O-Antigen ligase; Region: Wzy_C; pfam04932
1074919000372	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919000373	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1074919000374	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1074919000375	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
1074919000376	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1074919000377	putative NAD(P) binding site [chemical binding]; other site
1074919000378	active site
1074919000379	putative substrate binding site [chemical binding]; other site
1074919000380	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1074919000381	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1074919000382	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1074919000383	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1074919000384	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1074919000385	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1074919000386	active site
1074919000387	homodimer interface [polypeptide binding]; other site
1074919000388	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
1074919000389	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1074919000390	NAD(P) binding site [chemical binding]; other site
1074919000391	catalytic residues [active]
1074919000392	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1074919000393	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1074919000394	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
1074919000395	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1074919000396	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1074919000397	Walker A/P-loop; other site
1074919000398	ATP binding site [chemical binding]; other site
1074919000399	Q-loop/lid; other site
1074919000400	ABC transporter signature motif; other site
1074919000401	Walker B; other site
1074919000402	D-loop; other site
1074919000403	H-loop/switch region; other site
1074919000404	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1074919000405	NMT1-like family; Region: NMT1_2; pfam13379
1074919000406	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1074919000407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1074919000408	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1074919000409	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1074919000410	active site
1074919000411	formate dehydrogenase; Provisional; Region: PRK07574
1074919000412	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
1074919000413	dimerization interface [polypeptide binding]; other site
1074919000414	ligand binding site [chemical binding]; other site
1074919000415	NAD binding site [chemical binding]; other site
1074919000416	catalytic site [active]
1074919000417	putative transporter; Provisional; Region: PRK10054
1074919000418	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1074919000419	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1074919000420	acyl-activating enzyme (AAE) consensus motif; other site
1074919000421	AMP binding site [chemical binding]; other site
1074919000422	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1074919000423	Condensation domain; Region: Condensation; pfam00668
1074919000424	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1074919000425	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1074919000426	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1074919000427	acyl-activating enzyme (AAE) consensus motif; other site
1074919000428	AMP binding site [chemical binding]; other site
1074919000429	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1074919000430	thioester reductase domain; Region: Thioester-redct; TIGR01746
1074919000431	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919000432	NAD(P) binding site [chemical binding]; other site
1074919000433	active site
1074919000434	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1074919000435	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1074919000436	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
1074919000437	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1074919000438	nucleotide binding site [chemical binding]; other site
1074919000439	N-acetyl-L-glutamate binding site [chemical binding]; other site
1074919000440	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1074919000441	heterotetramer interface [polypeptide binding]; other site
1074919000442	active site pocket [active]
1074919000443	cleavage site
1074919000444	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1074919000445	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1074919000446	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1074919000447	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919000448	inhibitor-cofactor binding pocket; inhibition site
1074919000449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919000450	catalytic residue [active]
1074919000451	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1074919000452	Isochorismatase family; Region: Isochorismatase; pfam00857
1074919000453	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1074919000454	catalytic triad [active]
1074919000455	conserved cis-peptide bond; other site
1074919000456	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1074919000457	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1074919000458	dimer interface [polypeptide binding]; other site
1074919000459	PYR/PP interface [polypeptide binding]; other site
1074919000460	TPP binding site [chemical binding]; other site
1074919000461	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074919000462	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1074919000463	TPP-binding site [chemical binding]; other site
1074919000464	dimer interface [polypeptide binding]; other site
1074919000465	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919000466	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1074919000467	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919000468	active site turn [active]
1074919000469	phosphorylation site [posttranslational modification]
1074919000470	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1074919000471	HPr interaction site; other site
1074919000472	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074919000473	active site
1074919000474	phosphorylation site [posttranslational modification]
1074919000475	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1074919000476	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1074919000477	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
1074919000478	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1074919000479	putative active site [active]
1074919000480	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1074919000481	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919000482	active site turn [active]
1074919000483	phosphorylation site [posttranslational modification]
1074919000484	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919000485	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919000486	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1074919000487	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1074919000488	putative active site [active]
1074919000489	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1074919000490	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1074919000491	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919000492	ATP binding site [chemical binding]; other site
1074919000493	putative Mg++ binding site [ion binding]; other site
1074919000494	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1074919000495	HlyD family secretion protein; Region: HlyD_3; pfam13437
1074919000496	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919000497	Walker A/P-loop; other site
1074919000498	ATP binding site [chemical binding]; other site
1074919000499	ABC transporter; Region: ABC_tran; pfam00005
1074919000500	Q-loop/lid; other site
1074919000501	ABC transporter signature motif; other site
1074919000502	Walker B; other site
1074919000503	D-loop; other site
1074919000504	H-loop/switch region; other site
1074919000505	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074919000506	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1074919000507	FtsX-like permease family; Region: FtsX; pfam02687
1074919000508	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
1074919000509	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919000510	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919000511	Walker A/P-loop; other site
1074919000512	ATP binding site [chemical binding]; other site
1074919000513	Q-loop/lid; other site
1074919000514	ABC transporter signature motif; other site
1074919000515	Walker B; other site
1074919000516	D-loop; other site
1074919000517	H-loop/switch region; other site
1074919000518	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1074919000519	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919000520	Walker A/P-loop; other site
1074919000521	ATP binding site [chemical binding]; other site
1074919000522	Q-loop/lid; other site
1074919000523	ABC transporter signature motif; other site
1074919000524	Walker B; other site
1074919000525	D-loop; other site
1074919000526	H-loop/switch region; other site
1074919000527	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1074919000528	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919000529	Walker A/P-loop; other site
1074919000530	ATP binding site [chemical binding]; other site
1074919000531	Q-loop/lid; other site
1074919000532	ABC transporter signature motif; other site
1074919000533	Walker B; other site
1074919000534	D-loop; other site
1074919000535	H-loop/switch region; other site
1074919000536	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919000537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000538	dimer interface [polypeptide binding]; other site
1074919000539	conserved gate region; other site
1074919000540	putative PBP binding loops; other site
1074919000541	ABC-ATPase subunit interface; other site
1074919000542	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1074919000543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000544	dimer interface [polypeptide binding]; other site
1074919000545	conserved gate region; other site
1074919000546	ABC-ATPase subunit interface; other site
1074919000547	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1074919000548	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1074919000549	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1074919000550	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1074919000551	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1074919000552	Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742
1074919000553	azoreductase; Reviewed; Region: PRK00170
1074919000554	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074919000555	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074919000556	Peptidase family M23; Region: Peptidase_M23; pfam01551
1074919000557	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1074919000558	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1074919000559	Walker A/P-loop; other site
1074919000560	ATP binding site [chemical binding]; other site
1074919000561	Q-loop/lid; other site
1074919000562	ABC transporter signature motif; other site
1074919000563	Walker B; other site
1074919000564	D-loop; other site
1074919000565	H-loop/switch region; other site
1074919000566	TOBE domain; Region: TOBE; pfam03459
1074919000567	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1074919000568	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1074919000569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000570	dimer interface [polypeptide binding]; other site
1074919000571	conserved gate region; other site
1074919000572	ABC-ATPase subunit interface; other site
1074919000573	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1074919000574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000575	dimer interface [polypeptide binding]; other site
1074919000576	conserved gate region; other site
1074919000577	putative PBP binding loops; other site
1074919000578	ABC-ATPase subunit interface; other site
1074919000579	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1074919000580	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1074919000581	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1074919000582	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1074919000583	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1074919000584	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1074919000585	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1074919000586	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1074919000587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1074919000588	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1074919000589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000590	putative substrate translocation pore; other site
1074919000591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919000592	intermolecular recognition site; other site
1074919000593	active site
1074919000594	dimerization interface [polypeptide binding]; other site
1074919000595	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919000596	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1074919000597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919000598	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1074919000599	Histidine kinase; Region: His_kinase; pfam06580
1074919000600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919000601	ATP binding site [chemical binding]; other site
1074919000602	Mg2+ binding site [ion binding]; other site
1074919000603	G-X-G motif; other site
1074919000604	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1074919000605	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1074919000606	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1074919000607	Pyruvate formate lyase 1; Region: PFL1; cd01678
1074919000608	coenzyme A binding site [chemical binding]; other site
1074919000609	active site
1074919000610	catalytic residues [active]
1074919000611	glycine loop; other site
1074919000612	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1074919000613	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919000614	FeS/SAM binding site; other site
1074919000615	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1074919000616	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
1074919000617	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919000618	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1074919000619	putative active site [active]
1074919000620	catalytic site [active]
1074919000621	putative metal binding site [ion binding]; other site
1074919000622	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1074919000623	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000624	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000625	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000626	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000627	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000628	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000629	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1074919000630	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1074919000631	dimer interface [polypeptide binding]; other site
1074919000632	active site
1074919000633	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1074919000634	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1074919000635	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1074919000636	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1074919000637	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1074919000638	substrate binding site [chemical binding]; other site
1074919000639	oxyanion hole (OAH) forming residues; other site
1074919000640	trimer interface [polypeptide binding]; other site
1074919000641	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1074919000642	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1074919000643	active site
1074919000644	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1074919000645	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074919000646	acyl-activating enzyme (AAE) consensus motif; other site
1074919000647	AMP binding site [chemical binding]; other site
1074919000648	active site
1074919000649	CoA binding site [chemical binding]; other site
1074919000650	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1074919000651	Coenzyme A transferase; Region: CoA_trans; smart00882
1074919000652	Coenzyme A transferase; Region: CoA_trans; cl17247
1074919000653	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1074919000654	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1074919000655	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1074919000656	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1074919000657	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1074919000658	heme-binding site [chemical binding]; other site
1074919000659	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1074919000660	FAD binding pocket [chemical binding]; other site
1074919000661	FAD binding motif [chemical binding]; other site
1074919000662	phosphate binding motif [ion binding]; other site
1074919000663	beta-alpha-beta structure motif; other site
1074919000664	NAD binding pocket [chemical binding]; other site
1074919000665	Heme binding  pocket [chemical binding]; other site
1074919000666	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1074919000667	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1074919000668	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074919000669	NAD binding site [chemical binding]; other site
1074919000670	dimer interface [polypeptide binding]; other site
1074919000671	substrate binding site [chemical binding]; other site
1074919000672	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1074919000673	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919000674	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919000675	active site turn [active]
1074919000676	phosphorylation site [posttranslational modification]
1074919000677	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1074919000678	active site
1074919000679	tetramer interface [polypeptide binding]; other site
1074919000680	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919000681	Mga helix-turn-helix domain; Region: Mga; pfam05043
1074919000682	PRD domain; Region: PRD; pfam00874
1074919000683	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1074919000684	active site
1074919000685	P-loop; other site
1074919000686	phosphorylation site [posttranslational modification]
1074919000687	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919000688	active site
1074919000689	phosphorylation site [posttranslational modification]
1074919000690	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919000691	active site
1074919000692	phosphorylation site [posttranslational modification]
1074919000693	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1074919000694	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1074919000695	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1074919000696	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
1074919000697	putative NAD(P) binding site [chemical binding]; other site
1074919000698	catalytic Zn binding site [ion binding]; other site
1074919000699	structural Zn binding site [ion binding]; other site
1074919000700	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1074919000701	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
1074919000702	putative NAD(P) binding site [chemical binding]; other site
1074919000703	catalytic Zn binding site [ion binding]; other site
1074919000704	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1074919000705	substrate binding site; other site
1074919000706	dimer interface; other site
1074919000707	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1074919000708	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1074919000709	NAD(P) binding site [chemical binding]; other site
1074919000710	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919000711	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1074919000712	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919000713	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1074919000714	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1074919000715	substrate binding site; other site
1074919000716	dimer interface; other site
1074919000717	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1074919000718	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1074919000719	NAD(P) binding site [chemical binding]; other site
1074919000720	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919000721	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1074919000722	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1074919000723	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1074919000724	active site
1074919000725	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
1074919000726	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1074919000727	Hemerythrin-like domain; Region: Hr-like; cd12108
1074919000728	Fe binding site [ion binding]; other site
1074919000729	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1074919000730	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1074919000731	Histidine kinase; Region: His_kinase; pfam06580
1074919000732	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919000733	Mg2+ binding site [ion binding]; other site
1074919000734	G-X-G motif; other site
1074919000735	two-component response regulator; Provisional; Region: PRK14084
1074919000736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919000737	active site
1074919000738	phosphorylation site [posttranslational modification]
1074919000739	intermolecular recognition site; other site
1074919000740	dimerization interface [polypeptide binding]; other site
1074919000741	LytTr DNA-binding domain; Region: LytTR; pfam04397
1074919000742	antiholin-like protein LrgB; Provisional; Region: PRK04288
1074919000743	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1074919000744	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919000745	DNA-binding site [nucleotide binding]; DNA binding site
1074919000746	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1074919000747	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1074919000748	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1074919000749	HPr interaction site; other site
1074919000750	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074919000751	active site
1074919000752	phosphorylation site [posttranslational modification]
1074919000753	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1074919000754	beta-galactosidase; Region: BGL; TIGR03356
1074919000755	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1074919000756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919000757	S-adenosylmethionine binding site [chemical binding]; other site
1074919000758	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1074919000759	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1074919000760	substrate binding site [chemical binding]; other site
1074919000761	dimer interface [polypeptide binding]; other site
1074919000762	ATP binding site [chemical binding]; other site
1074919000763	D-ribose pyranase; Provisional; Region: PRK11797
1074919000764	Sugar transport protein; Region: Sugar_transport; pfam06800
1074919000765	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1074919000766	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1074919000767	DNA binding site [nucleotide binding]
1074919000768	domain linker motif; other site
1074919000769	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1074919000770	dimerization interface [polypeptide binding]; other site
1074919000771	ligand binding site [chemical binding]; other site
1074919000772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000774	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1074919000775	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1074919000776	active site
1074919000777	Surface antigen [General function prediction only]; Region: COG3942
1074919000778	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074919000779	Peptidase family M23; Region: Peptidase_M23; pfam01551
1074919000780	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919000781	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1074919000782	Walker A/P-loop; other site
1074919000783	ATP binding site [chemical binding]; other site
1074919000784	Q-loop/lid; other site
1074919000785	ABC transporter signature motif; other site
1074919000786	Walker B; other site
1074919000787	D-loop; other site
1074919000788	H-loop/switch region; other site
1074919000789	Surface antigen [General function prediction only]; Region: COG3942
1074919000790	CHAP domain; Region: CHAP; pfam05257
1074919000791	Predicted membrane protein [Function unknown]; Region: COG1511
1074919000792	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1074919000793	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1074919000794	Predicted membrane protein [Function unknown]; Region: COG4499
1074919000795	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1074919000796	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1074919000797	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1074919000798	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074919000799	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074919000800	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1074919000801	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1074919000802	Protein of unknown function, DUF600; Region: DUF600; cl04640
1074919000803	Protein of unknown function, DUF600; Region: DUF600; cl04640
1074919000804	Protein of unknown function, DUF600; Region: DUF600; cl04640
1074919000805	Protein of unknown function, DUF600; Region: DUF600; cl04640
1074919000806	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1074919000807	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1074919000808	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
1074919000809	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1074919000810	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074919000811	FtsX-like permease family; Region: FtsX; pfam02687
1074919000812	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919000813	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919000814	Walker A/P-loop; other site
1074919000815	ATP binding site [chemical binding]; other site
1074919000816	Q-loop/lid; other site
1074919000817	ABC transporter signature motif; other site
1074919000818	Walker B; other site
1074919000819	D-loop; other site
1074919000820	H-loop/switch region; other site
1074919000821	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1074919000822	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1074919000823	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919000824	non-specific DNA binding site [nucleotide binding]; other site
1074919000825	salt bridge; other site
1074919000826	sequence-specific DNA binding site [nucleotide binding]; other site
1074919000827	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1074919000828	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1074919000829	substrate binding site [chemical binding]; other site
1074919000830	ATP binding site [chemical binding]; other site
1074919000831	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
1074919000832	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1074919000833	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1074919000834	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1074919000835	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
1074919000836	putative transporter; Provisional; Region: PRK10484
1074919000837	Na binding site [ion binding]; other site
1074919000838	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1074919000839	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1074919000840	inhibitor site; inhibition site
1074919000841	active site
1074919000842	dimer interface [polypeptide binding]; other site
1074919000843	catalytic residue [active]
1074919000844	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1074919000845	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1074919000846	nucleotide binding site [chemical binding]; other site
1074919000847	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1074919000848	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919000849	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1074919000850	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1074919000851	putative active site [active]
1074919000852	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1074919000853	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1074919000854	putative active site cavity [active]
1074919000855	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1074919000856	Nucleoside recognition; Region: Gate; pfam07670
1074919000857	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1074919000858	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1074919000859	PGAP1-like protein; Region: PGAP1; pfam07819
1074919000860	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1074919000861	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1074919000862	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1074919000863	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1074919000864	putative active site [active]
1074919000865	putative FMN binding site [chemical binding]; other site
1074919000866	putative substrate binding site [chemical binding]; other site
1074919000867	putative catalytic residue [active]
1074919000868	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1074919000869	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1074919000870	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1074919000871	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1074919000872	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
1074919000873	putative ADP-ribose binding site [chemical binding]; other site
1074919000874	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
1074919000875	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1074919000876	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1074919000877	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1074919000878	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1074919000879	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
1074919000880	NADP binding site [chemical binding]; other site
1074919000881	putative substrate binding site [chemical binding]; other site
1074919000882	active site
1074919000883	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1074919000884	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919000885	HTH domain; Region: HTH_11; pfam08279
1074919000886	HTH domain; Region: HTH_11; pfam08279
1074919000887	PRD domain; Region: PRD; pfam00874
1074919000888	PRD domain; Region: PRD; pfam00874
1074919000889	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1074919000890	active site
1074919000891	P-loop; other site
1074919000892	phosphorylation site [posttranslational modification]
1074919000893	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919000894	active site
1074919000895	phosphorylation site [posttranslational modification]
1074919000896	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1074919000897	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1074919000898	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1074919000899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000900	putative substrate translocation pore; other site
1074919000901	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000902	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1074919000903	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1074919000904	Zn binding site [ion binding]; other site
1074919000905	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1074919000906	Zn binding site [ion binding]; other site
1074919000907	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1074919000908	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1074919000909	Predicted flavoprotein [General function prediction only]; Region: COG0431
1074919000910	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074919000911	Predicted membrane protein [Function unknown]; Region: COG2855
1074919000912	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1074919000913	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919000914	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
1074919000915	Imelysin; Region: Peptidase_M75; pfam09375
1074919000916	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1074919000917	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1074919000918	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1074919000919	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1074919000920	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
1074919000921	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074919000922	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919000923	Walker A/P-loop; other site
1074919000924	ATP binding site [chemical binding]; other site
1074919000925	Q-loop/lid; other site
1074919000926	ABC transporter signature motif; other site
1074919000927	Walker B; other site
1074919000928	D-loop; other site
1074919000929	H-loop/switch region; other site
1074919000930	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1074919000931	Predicted membrane protein [Function unknown]; Region: COG4292
1074919000932	putative acyltransferase; Provisional; Region: PRK05790
1074919000933	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1074919000934	dimer interface [polypeptide binding]; other site
1074919000935	active site
1074919000936	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1074919000937	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1074919000938	methionine synthase; Provisional; Region: PRK01207
1074919000939	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1074919000940	substrate binding site [chemical binding]; other site
1074919000941	THF binding site; other site
1074919000942	zinc-binding site [ion binding]; other site
1074919000943	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1074919000944	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1074919000945	FAD binding site [chemical binding]; other site
1074919000946	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1074919000947	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1074919000948	homodimer interface [polypeptide binding]; other site
1074919000949	substrate-cofactor binding pocket; other site
1074919000950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919000951	catalytic residue [active]
1074919000952	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1074919000953	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1074919000954	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919000955	catalytic residue [active]
1074919000956	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1074919000957	ParB-like nuclease domain; Region: ParB; smart00470
1074919000958	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1074919000959	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1074919000960	GTP-binding protein YchF; Reviewed; Region: PRK09601
1074919000961	YchF GTPase; Region: YchF; cd01900
1074919000962	G1 box; other site
1074919000963	GTP/Mg2+ binding site [chemical binding]; other site
1074919000964	Switch I region; other site
1074919000965	G2 box; other site
1074919000966	Switch II region; other site
1074919000967	G3 box; other site
1074919000968	G4 box; other site
1074919000969	G5 box; other site
1074919000970	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1074919000971	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1074919000972	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1074919000973	dimer interface [polypeptide binding]; other site
1074919000974	ssDNA binding site [nucleotide binding]; other site
1074919000975	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074919000976	Abi-like protein; Region: Abi_2; pfam07751
1074919000977	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919000978	Predicted membrane protein [Function unknown]; Region: COG3212
1074919000979	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1074919000980	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074919000981	catalytic core [active]
1074919000982	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
1074919000983	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1074919000984	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1074919000985	catalytic residue [active]
1074919000986	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1074919000987	catalytic residues [active]
1074919000988	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919000989	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919000990	peroxiredoxin; Region: AhpC; TIGR03137
1074919000991	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1074919000992	dimer interface [polypeptide binding]; other site
1074919000993	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1074919000994	catalytic triad [active]
1074919000995	peroxidatic and resolving cysteines [active]
1074919000996	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1074919000997	dimer interface [polypeptide binding]; other site
1074919000998	FMN binding site [chemical binding]; other site
1074919000999	NADPH bind site [chemical binding]; other site
1074919001000	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1074919001001	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1074919001002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919001003	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919001004	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919001005	active site
1074919001006	xanthine permease; Region: pbuX; TIGR03173
1074919001007	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1074919001008	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1074919001009	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1074919001010	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1074919001011	active site
1074919001012	GMP synthase; Reviewed; Region: guaA; PRK00074
1074919001013	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1074919001014	AMP/PPi binding site [chemical binding]; other site
1074919001015	candidate oxyanion hole; other site
1074919001016	catalytic triad [active]
1074919001017	potential glutamine specificity residues [chemical binding]; other site
1074919001018	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1074919001019	ATP Binding subdomain [chemical binding]; other site
1074919001020	Ligand Binding sites [chemical binding]; other site
1074919001021	Dimerization subdomain; other site
1074919001022	PemK-like protein; Region: PemK; pfam02452
1074919001023	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1074919001024	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1074919001025	NADP binding site [chemical binding]; other site
1074919001026	superantigen-like protein; Reviewed; Region: PRK13037
1074919001027	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001028	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001029	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001030	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001031	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001032	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001033	superantigen-like protein; Reviewed; Region: PRK13042
1074919001034	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001035	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001036	superantigen-like protein 5; Reviewed; Region: PRK13035
1074919001037	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001038	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001039	superantigen-like protein 7; Reviewed; Region: PRK13346
1074919001040	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001041	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001042	superantigen-like protein; Reviewed; Region: PRK13039
1074919001043	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001044	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001045	superantigen-like protein; Reviewed; Region: PRK13345
1074919001046	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001047	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001048	superantigen-like protein 5; Reviewed; Region: PRK13035
1074919001049	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001050	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001051	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1074919001052	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1074919001053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919001054	S-adenosylmethionine binding site [chemical binding]; other site
1074919001055	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1074919001056	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1074919001057	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1074919001058	superantigen-like protein; Reviewed; Region: PRK13036
1074919001059	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001060	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001061	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001062	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001063	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001064	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001065	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001066	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001067	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001068	Protein of unknown function, DUF576; Region: DUF576; cl04553
1074919001069	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001070	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001071	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001072	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1074919001073	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1074919001074	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1074919001075	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1074919001076	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1074919001077	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919001078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1074919001079	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1074919001080	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1074919001081	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1074919001082	active site
1074919001083	Esterase/lipase [General function prediction only]; Region: COG1647
1074919001084	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074919001085	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1074919001086	Na2 binding site [ion binding]; other site
1074919001087	putative substrate binding site 1 [chemical binding]; other site
1074919001088	Na binding site 1 [ion binding]; other site
1074919001089	putative substrate binding site 2 [chemical binding]; other site
1074919001090	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1074919001091	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1074919001092	dimer interface [polypeptide binding]; other site
1074919001093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001094	catalytic residue [active]
1074919001095	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1074919001096	substrate-cofactor binding pocket; other site
1074919001097	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001098	catalytic residue [active]
1074919001099	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1074919001100	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1074919001101	Walker A/P-loop; other site
1074919001102	ATP binding site [chemical binding]; other site
1074919001103	Q-loop/lid; other site
1074919001104	ABC transporter signature motif; other site
1074919001105	Walker B; other site
1074919001106	D-loop; other site
1074919001107	H-loop/switch region; other site
1074919001108	NIL domain; Region: NIL; pfam09383
1074919001109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919001110	dimer interface [polypeptide binding]; other site
1074919001111	conserved gate region; other site
1074919001112	ABC-ATPase subunit interface; other site
1074919001113	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1074919001114	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1074919001115	LysM domain; Region: LysM; pfam01476
1074919001116	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919001117	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919001118	Surface antigen [General function prediction only]; Region: COG3942
1074919001119	CHAP domain; Region: CHAP; pfam05257
1074919001120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919001121	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919001122	Coenzyme A binding pocket [chemical binding]; other site
1074919001123	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1074919001124	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1074919001125	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919001126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919001127	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1074919001128	dimerization interface [polypeptide binding]; other site
1074919001129	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1074919001130	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1074919001131	active site
1074919001132	dimer interface [polypeptide binding]; other site
1074919001133	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1074919001134	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1074919001135	active site
1074919001136	FMN binding site [chemical binding]; other site
1074919001137	substrate binding site [chemical binding]; other site
1074919001138	3Fe-4S cluster binding site [ion binding]; other site
1074919001139	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1074919001140	domain interface; other site
1074919001141	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1074919001142	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074919001143	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1074919001144	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919001145	active site turn [active]
1074919001146	phosphorylation site [posttranslational modification]
1074919001147	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919001148	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1074919001149	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1074919001150	Ca binding site [ion binding]; other site
1074919001151	active site
1074919001152	catalytic site [active]
1074919001153	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1074919001154	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919001155	DNA-binding site [nucleotide binding]; DNA binding site
1074919001156	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1074919001157	UTRA domain; Region: UTRA; pfam07702
1074919001158	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919001159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919001160	Coenzyme A binding pocket [chemical binding]; other site
1074919001161	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1074919001162	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919001163	Walker A motif; other site
1074919001164	ATP binding site [chemical binding]; other site
1074919001165	Walker B motif; other site
1074919001166	arginine finger; other site
1074919001167	recombination protein RecR; Reviewed; Region: recR; PRK00076
1074919001168	RecR protein; Region: RecR; pfam02132
1074919001169	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1074919001170	putative active site [active]
1074919001171	putative metal-binding site [ion binding]; other site
1074919001172	tetramer interface [polypeptide binding]; other site
1074919001173	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1074919001174	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1074919001175	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919001176	catalytic residue [active]
1074919001177	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1074919001178	thymidylate kinase; Validated; Region: tmk; PRK00698
1074919001179	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1074919001180	TMP-binding site; other site
1074919001181	ATP-binding site [chemical binding]; other site
1074919001182	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1074919001183	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1074919001184	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1074919001185	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1074919001186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919001187	S-adenosylmethionine binding site [chemical binding]; other site
1074919001188	Predicted methyltransferases [General function prediction only]; Region: COG0313
1074919001189	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1074919001190	putative SAM binding site [chemical binding]; other site
1074919001191	putative homodimer interface [polypeptide binding]; other site
1074919001192	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1074919001193	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1074919001194	active site
1074919001195	HIGH motif; other site
1074919001196	KMSKS motif; other site
1074919001197	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1074919001198	tRNA binding surface [nucleotide binding]; other site
1074919001199	anticodon binding site; other site
1074919001200	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1074919001201	dimer interface [polypeptide binding]; other site
1074919001202	putative tRNA-binding site [nucleotide binding]; other site
1074919001203	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1074919001204	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1074919001205	active site
1074919001206	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1074919001207	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1074919001208	putative active site [active]
1074919001209	putative metal binding site [ion binding]; other site
1074919001210	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1074919001211	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1074919001212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919001213	S-adenosylmethionine binding site [chemical binding]; other site
1074919001214	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1074919001215	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1074919001216	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1074919001217	pur operon repressor; Provisional; Region: PRK09213
1074919001218	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1074919001219	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919001220	active site
1074919001221	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1074919001222	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1074919001223	Substrate binding site; other site
1074919001224	Mg++ binding site; other site
1074919001225	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1074919001226	active site
1074919001227	substrate binding site [chemical binding]; other site
1074919001228	CoA binding site [chemical binding]; other site
1074919001229	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1074919001230	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1074919001231	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919001232	active site
1074919001233	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1074919001234	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1074919001235	5S rRNA interface [nucleotide binding]; other site
1074919001236	CTC domain interface [polypeptide binding]; other site
1074919001237	L16 interface [polypeptide binding]; other site
1074919001238	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1074919001239	putative active site [active]
1074919001240	catalytic residue [active]
1074919001241	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1074919001242	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
1074919001243	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919001244	ATP binding site [chemical binding]; other site
1074919001245	putative Mg++ binding site [ion binding]; other site
1074919001246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919001247	nucleotide binding region [chemical binding]; other site
1074919001248	ATP-binding site [chemical binding]; other site
1074919001249	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1074919001250	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1074919001251	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1074919001252	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
1074919001253	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1074919001254	putative SAM binding site [chemical binding]; other site
1074919001255	putative homodimer interface [polypeptide binding]; other site
1074919001256	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1074919001257	homodimer interface [polypeptide binding]; other site
1074919001258	metal binding site [ion binding]; metal-binding site
1074919001259	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1074919001260	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1074919001261	Ligand Binding Site [chemical binding]; other site
1074919001262	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1074919001263	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1074919001264	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919001265	active site
1074919001266	FtsH Extracellular; Region: FtsH_ext; pfam06480
1074919001267	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1074919001268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919001269	Walker A motif; other site
1074919001270	ATP binding site [chemical binding]; other site
1074919001271	Walker B motif; other site
1074919001272	arginine finger; other site
1074919001273	Peptidase family M41; Region: Peptidase_M41; pfam01434
1074919001274	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1074919001275	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1074919001276	dimerization interface [polypeptide binding]; other site
1074919001277	domain crossover interface; other site
1074919001278	redox-dependent activation switch; other site
1074919001279	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1074919001280	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1074919001281	dimer interface [polypeptide binding]; other site
1074919001282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001283	catalytic residue [active]
1074919001284	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1074919001285	dihydropteroate synthase; Region: DHPS; TIGR01496
1074919001286	substrate binding pocket [chemical binding]; other site
1074919001287	dimer interface [polypeptide binding]; other site
1074919001288	inhibitor binding site; inhibition site
1074919001289	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1074919001290	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1074919001291	dimer interface [polypeptide binding]; other site
1074919001292	putative anticodon binding site; other site
1074919001293	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1074919001294	motif 1; other site
1074919001295	active site
1074919001296	motif 2; other site
1074919001297	motif 3; other site
1074919001298	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1074919001299	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919001300	DNA-binding site [nucleotide binding]; DNA binding site
1074919001301	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919001302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001303	homodimer interface [polypeptide binding]; other site
1074919001304	catalytic residue [active]
1074919001305	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1074919001306	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1074919001307	active site
1074919001308	multimer interface [polypeptide binding]; other site
1074919001309	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1074919001310	predicted active site [active]
1074919001311	catalytic triad [active]
1074919001312	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1074919001313	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1074919001314	Nucleoside recognition; Region: Gate; pfam07670
1074919001315	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1074919001316	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
1074919001317	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1074919001318	UvrB/uvrC motif; Region: UVR; pfam02151
1074919001319	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
1074919001320	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1074919001321	ADP binding site [chemical binding]; other site
1074919001322	phosphagen binding site; other site
1074919001323	substrate specificity loop; other site
1074919001324	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1074919001325	Clp amino terminal domain; Region: Clp_N; pfam02861
1074919001326	Clp amino terminal domain; Region: Clp_N; pfam02861
1074919001327	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919001328	Walker A motif; other site
1074919001329	ATP binding site [chemical binding]; other site
1074919001330	Walker B motif; other site
1074919001331	arginine finger; other site
1074919001332	UvrB/uvrC motif; Region: UVR; pfam02151
1074919001333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919001334	Walker A motif; other site
1074919001335	ATP binding site [chemical binding]; other site
1074919001336	Walker B motif; other site
1074919001337	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1074919001338	DNA repair protein RadA; Provisional; Region: PRK11823
1074919001339	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1074919001340	Walker A motif/ATP binding site; other site
1074919001341	ATP binding site [chemical binding]; other site
1074919001342	Walker B motif; other site
1074919001343	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1074919001344	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1074919001345	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1074919001346	putative active site [active]
1074919001347	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1074919001348	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1074919001349	active site
1074919001350	HIGH motif; other site
1074919001351	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1074919001352	active site
1074919001353	KMSKS motif; other site
1074919001354	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1074919001355	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1074919001356	trimer interface [polypeptide binding]; other site
1074919001357	active site
1074919001358	substrate binding site [chemical binding]; other site
1074919001359	CoA binding site [chemical binding]; other site
1074919001360	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1074919001361	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1074919001362	active site
1074919001363	HIGH motif; other site
1074919001364	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1074919001365	KMSKS motif; other site
1074919001366	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1074919001367	tRNA binding surface [nucleotide binding]; other site
1074919001368	anticodon binding site; other site
1074919001369	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1074919001370	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1074919001371	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1074919001372	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
1074919001373	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1074919001374	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074919001375	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1074919001376	DNA binding residues [nucleotide binding]
1074919001377	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1074919001378	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1074919001379	putative homodimer interface [polypeptide binding]; other site
1074919001380	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1074919001381	heterodimer interface [polypeptide binding]; other site
1074919001382	homodimer interface [polypeptide binding]; other site
1074919001383	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1074919001384	mRNA/rRNA interface [nucleotide binding]; other site
1074919001385	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1074919001386	23S rRNA interface [nucleotide binding]; other site
1074919001387	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1074919001388	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1074919001389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919001390	S-adenosylmethionine binding site [chemical binding]; other site
1074919001391	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1074919001392	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1074919001393	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1074919001394	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1074919001395	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1074919001396	RPB10 interaction site [polypeptide binding]; other site
1074919001397	RPB1 interaction site [polypeptide binding]; other site
1074919001398	RPB11 interaction site [polypeptide binding]; other site
1074919001399	RPB3 interaction site [polypeptide binding]; other site
1074919001400	RPB12 interaction site [polypeptide binding]; other site
1074919001401	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1074919001402	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1074919001403	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1074919001404	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1074919001405	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1074919001406	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1074919001407	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1074919001408	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1074919001409	G-loop; other site
1074919001410	DNA binding site [nucleotide binding]
1074919001411	30S ribosomal protein S7; Validated; Region: PRK05302
1074919001412	elongation factor G; Reviewed; Region: PRK00007
1074919001413	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1074919001414	G1 box; other site
1074919001415	putative GEF interaction site [polypeptide binding]; other site
1074919001416	GTP/Mg2+ binding site [chemical binding]; other site
1074919001417	Switch I region; other site
1074919001418	G2 box; other site
1074919001419	G3 box; other site
1074919001420	Switch II region; other site
1074919001421	G4 box; other site
1074919001422	G5 box; other site
1074919001423	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1074919001424	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1074919001425	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1074919001426	elongation factor Tu; Reviewed; Region: PRK00049
1074919001427	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1074919001428	G1 box; other site
1074919001429	GEF interaction site [polypeptide binding]; other site
1074919001430	GTP/Mg2+ binding site [chemical binding]; other site
1074919001431	Switch I region; other site
1074919001432	G2 box; other site
1074919001433	G3 box; other site
1074919001434	Switch II region; other site
1074919001435	G4 box; other site
1074919001436	G5 box; other site
1074919001437	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1074919001438	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1074919001439	Antibiotic Binding Site [chemical binding]; other site
1074919001440	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074919001441	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1074919001442	metal binding site [ion binding]; metal-binding site
1074919001443	dimer interface [polypeptide binding]; other site
1074919001444	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1074919001445	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1074919001446	substrate-cofactor binding pocket; other site
1074919001447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001448	catalytic residue [active]
1074919001449	chaperone protein HchA; Provisional; Region: PRK04155
1074919001450	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
1074919001451	dimer interface [polypeptide binding]; other site
1074919001452	metal binding site [ion binding]; metal-binding site
1074919001453	potential oxyanion hole; other site
1074919001454	potential catalytic triad [active]
1074919001455	conserved cys residue [active]
1074919001456	ribulokinase; Provisional; Region: PRK04123
1074919001457	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1074919001458	N- and C-terminal domain interface [polypeptide binding]; other site
1074919001459	active site
1074919001460	MgATP binding site [chemical binding]; other site
1074919001461	catalytic site [active]
1074919001462	metal binding site [ion binding]; metal-binding site
1074919001463	carbohydrate binding site [chemical binding]; other site
1074919001464	homodimer interface [polypeptide binding]; other site
1074919001465	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1074919001466	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919001467	NAD(P) binding site [chemical binding]; other site
1074919001468	active site
1074919001469	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1074919001470	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1074919001471	homodimer interface [polypeptide binding]; other site
1074919001472	substrate-cofactor binding pocket; other site
1074919001473	catalytic residue [active]
1074919001474	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1074919001475	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001476	motif II; other site
1074919001477	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1074919001478	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1074919001479	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1074919001480	Substrate-binding site [chemical binding]; other site
1074919001481	Substrate specificity [chemical binding]; other site
1074919001482	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001483	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1074919001484	active site
1074919001485	motif I; other site
1074919001486	motif II; other site
1074919001487	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001488	Predicted flavoprotein [General function prediction only]; Region: COG0431
1074919001489	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074919001490	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919001491	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919001492	Cna protein B-type domain; Region: Cna_B; pfam05738
1074919001493	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001494	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919001495	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919001496	Cna protein B-type domain; Region: Cna_B; pfam05738
1074919001497	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001498	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001499	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001500	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001501	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919001502	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919001503	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001504	Cna protein B-type domain; Region: Cna_B; pfam05738
1074919001505	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001506	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1074919001507	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1074919001508	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919001509	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1074919001510	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1074919001511	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919001512	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919001513	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919001514	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1074919001515	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
1074919001516	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1074919001517	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1074919001518	active site
1074919001519	trimer interface [polypeptide binding]; other site
1074919001520	allosteric site; other site
1074919001521	active site lid [active]
1074919001522	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1074919001523	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1074919001524	active site
1074919001525	dimer interface [polypeptide binding]; other site
1074919001526	magnesium binding site [ion binding]; other site
1074919001527	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1074919001528	tetramer interface [polypeptide binding]; other site
1074919001529	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919001530	active site
1074919001531	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1074919001532	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001533	motif II; other site
1074919001534	proline/glycine betaine transporter; Provisional; Region: PRK10642
1074919001535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919001536	putative substrate translocation pore; other site
1074919001537	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1074919001538	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1074919001539	acyl-activating enzyme (AAE) consensus motif; other site
1074919001540	AMP binding site [chemical binding]; other site
1074919001541	active site
1074919001542	CoA binding site [chemical binding]; other site
1074919001543	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1074919001544	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1074919001545	dimer interface [polypeptide binding]; other site
1074919001546	active site
1074919001547	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1074919001548	dimer interface [polypeptide binding]; other site
1074919001549	substrate binding site [chemical binding]; other site
1074919001550	ATP binding site [chemical binding]; other site
1074919001551	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1074919001552	ligand binding site [chemical binding]; other site
1074919001553	active site
1074919001554	UGI interface [polypeptide binding]; other site
1074919001555	catalytic site [active]
1074919001556	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1074919001557	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1074919001558	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1074919001559	putative heme peroxidase; Provisional; Region: PRK12276
1074919001560	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1074919001561	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1074919001562	mevalonate kinase; Region: mevalon_kin; TIGR00549
1074919001563	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1074919001564	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1074919001565	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
1074919001566	diphosphomevalonate decarboxylase; Region: PLN02407
1074919001567	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1074919001568	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1074919001569	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1074919001570	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1074919001571	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1074919001572	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919001573	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074919001574	LXG domain of WXG superfamily; Region: LXG; pfam04740
1074919001575	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1074919001576	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1074919001577	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1074919001578	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919001579	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074919001580	active site
1074919001581	catalytic tetrad [active]
1074919001582	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1074919001583	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074919001584	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1074919001585	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919001586	Coenzyme A binding pocket [chemical binding]; other site
1074919001587	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1074919001588	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919001589	Zn2+ binding site [ion binding]; other site
1074919001590	Mg2+ binding site [ion binding]; other site
1074919001591	YwhD family; Region: YwhD; pfam08741
1074919001592	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1074919001593	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1074919001594	NAD binding site [chemical binding]; other site
1074919001595	substrate binding site [chemical binding]; other site
1074919001596	catalytic Zn binding site [ion binding]; other site
1074919001597	tetramer interface [polypeptide binding]; other site
1074919001598	structural Zn binding site [ion binding]; other site
1074919001599	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1074919001600	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
1074919001601	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1074919001602	active site
1074919001603	HIGH motif; other site
1074919001604	KMSK motif region; other site
1074919001605	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1074919001606	tRNA binding surface [nucleotide binding]; other site
1074919001607	anticodon binding site; other site
1074919001608	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
1074919001609	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1074919001610	minor groove reading motif; other site
1074919001611	helix-hairpin-helix signature motif; other site
1074919001612	substrate binding pocket [chemical binding]; other site
1074919001613	active site
1074919001614	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1074919001615	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1074919001616	putative binding site residues; other site
1074919001617	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1074919001618	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001619	ABC-ATPase subunit  interface; other site
1074919001620	dimer interface [polypeptide binding]; other site
1074919001621	putative PBP binding regions; other site
1074919001622	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1074919001623	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001624	motif II; other site
1074919001625	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1074919001626	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074919001627	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1074919001628	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074919001629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1074919001630	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1074919001631	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919001632	active site
1074919001633	DNA binding site [nucleotide binding]
1074919001634	Int/Topo IB signature motif; other site
1074919001635	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
1074919001636	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919001637	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1074919001638	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
1074919001639	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919001640	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1074919001641	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
1074919001642	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1074919001643	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1074919001644	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919001645	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919001646	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074919001647	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1074919001648	intersubunit interface [polypeptide binding]; other site
1074919001649	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1074919001650	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001651	ABC-ATPase subunit  interface; other site
1074919001652	dimer interface [polypeptide binding]; other site
1074919001653	putative PBP binding regions; other site
1074919001654	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1074919001655	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1074919001656	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1074919001657	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1074919001658	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1074919001659	FeoA domain; Region: FeoA; pfam04023
1074919001660	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1074919001661	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1074919001662	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1074919001663	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
1074919001664	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1074919001665	Walker A/P-loop; other site
1074919001666	ATP binding site [chemical binding]; other site
1074919001667	Q-loop/lid; other site
1074919001668	ABC transporter signature motif; other site
1074919001669	Walker B; other site
1074919001670	D-loop; other site
1074919001671	H-loop/switch region; other site
1074919001672	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1074919001673	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1074919001674	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919001675	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1074919001676	active site
1074919001677	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1074919001678	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1074919001679	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
1074919001680	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1074919001681	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919001682	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919001683	Walker A/P-loop; other site
1074919001684	ATP binding site [chemical binding]; other site
1074919001685	Q-loop/lid; other site
1074919001686	ABC transporter signature motif; other site
1074919001687	Walker B; other site
1074919001688	D-loop; other site
1074919001689	H-loop/switch region; other site
1074919001690	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1074919001691	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1074919001692	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1074919001693	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1074919001694	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1074919001695	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1074919001696	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074919001697	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074919001698	Walker A/P-loop; other site
1074919001699	ATP binding site [chemical binding]; other site
1074919001700	Q-loop/lid; other site
1074919001701	ABC transporter signature motif; other site
1074919001702	Walker B; other site
1074919001703	D-loop; other site
1074919001704	H-loop/switch region; other site
1074919001705	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074919001706	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001707	ABC-ATPase subunit  interface; other site
1074919001708	dimer interface [polypeptide binding]; other site
1074919001709	putative PBP binding regions; other site
1074919001710	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1074919001711	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001712	ABC-ATPase subunit  interface; other site
1074919001713	dimer interface [polypeptide binding]; other site
1074919001714	putative PBP binding regions; other site
1074919001715	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1074919001716	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1074919001717	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1074919001718	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1074919001719	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1074919001720	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1074919001721	Na binding site [ion binding]; other site
1074919001722	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1074919001723	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1074919001724	substrate binding pocket [chemical binding]; other site
1074919001725	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1074919001726	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919001727	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919001728	Coenzyme A binding pocket [chemical binding]; other site
1074919001729	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919001730	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1074919001731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919001732	NAD(P) binding site [chemical binding]; other site
1074919001733	active site
1074919001734	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919001735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919001736	active site
1074919001737	phosphorylation site [posttranslational modification]
1074919001738	intermolecular recognition site; other site
1074919001739	dimerization interface [polypeptide binding]; other site
1074919001740	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919001741	DNA binding site [nucleotide binding]
1074919001742	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919001743	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1074919001744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919001745	ATP binding site [chemical binding]; other site
1074919001746	Mg2+ binding site [ion binding]; other site
1074919001747	G-X-G motif; other site
1074919001748	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919001749	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919001750	Walker A/P-loop; other site
1074919001751	ATP binding site [chemical binding]; other site
1074919001752	Q-loop/lid; other site
1074919001753	ABC transporter signature motif; other site
1074919001754	Walker B; other site
1074919001755	D-loop; other site
1074919001756	H-loop/switch region; other site
1074919001757	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1074919001758	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1074919001759	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919001760	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1074919001761	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919001762	Surface antigen [General function prediction only]; Region: COG3942
1074919001763	CHAP domain; Region: CHAP; pfam05257
1074919001764	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1074919001765	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
1074919001766	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1074919001767	hypothetical protein; Provisional; Region: PRK12378
1074919001768	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
1074919001769	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1074919001770	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919001771	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919001772	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1074919001773	dimerization interface [polypeptide binding]; other site
1074919001774	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919001775	sugar efflux transporter; Region: 2A0120; TIGR00899
1074919001776	putative substrate translocation pore; other site
1074919001777	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
1074919001778	Serine incorporator (Serinc); Region: Serinc; pfam03348
1074919001779	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1074919001780	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1074919001781	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
1074919001782	hypothetical protein; Validated; Region: PRK00124
1074919001783	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1074919001784	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1074919001785	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1074919001786	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919001787	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1074919001788	Walker A/P-loop; other site
1074919001789	ATP binding site [chemical binding]; other site
1074919001790	Q-loop/lid; other site
1074919001791	ABC transporter signature motif; other site
1074919001792	Walker B; other site
1074919001793	D-loop; other site
1074919001794	H-loop/switch region; other site
1074919001795	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1074919001796	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919001797	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1074919001798	Walker A/P-loop; other site
1074919001799	ATP binding site [chemical binding]; other site
1074919001800	Q-loop/lid; other site
1074919001801	ABC transporter signature motif; other site
1074919001802	Walker B; other site
1074919001803	D-loop; other site
1074919001804	H-loop/switch region; other site
1074919001805	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1074919001806	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1074919001807	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1074919001808	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919001809	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074919001810	active site
1074919001811	catalytic tetrad [active]
1074919001812	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1074919001813	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1074919001814	transmembrane helices; other site
1074919001815	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1074919001816	DNA photolyase; Region: DNA_photolyase; pfam00875
1074919001817	Predicted membrane protein [Function unknown]; Region: COG4330
1074919001818	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1074919001819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919001820	putative substrate translocation pore; other site
1074919001821	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1074919001822	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1074919001823	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1074919001824	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1074919001825	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1074919001826	putative substrate binding site [chemical binding]; other site
1074919001827	putative ATP binding site [chemical binding]; other site
1074919001828	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1074919001829	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919001830	active site
1074919001831	phosphorylation site [posttranslational modification]
1074919001832	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1074919001833	active site
1074919001834	P-loop; other site
1074919001835	phosphorylation site [posttranslational modification]
1074919001836	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1074919001837	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1074919001838	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1074919001839	active site
1074919001840	dimer interface [polypeptide binding]; other site
1074919001841	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1074919001842	Domain of unknown function DUF21; Region: DUF21; pfam01595
1074919001843	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1074919001844	Transporter associated domain; Region: CorC_HlyC; pfam03471
1074919001845	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919001846	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074919001847	active site
1074919001848	catalytic tetrad [active]
1074919001849	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1074919001850	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1074919001851	Ligand binding site; other site
1074919001852	Putative Catalytic site; other site
1074919001853	DXD motif; other site
1074919001854	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919001855	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919001856	dimer interface [polypeptide binding]; other site
1074919001857	phosphorylation site [posttranslational modification]
1074919001858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919001859	ATP binding site [chemical binding]; other site
1074919001860	Mg2+ binding site [ion binding]; other site
1074919001861	G-X-G motif; other site
1074919001862	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919001863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919001864	active site
1074919001865	phosphorylation site [posttranslational modification]
1074919001866	intermolecular recognition site; other site
1074919001867	dimerization interface [polypeptide binding]; other site
1074919001868	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919001869	DNA binding site [nucleotide binding]
1074919001870	DoxX; Region: DoxX; pfam07681
1074919001871	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1074919001872	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1074919001873	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1074919001874	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1074919001875	Ligand Binding Site [chemical binding]; other site
1074919001876	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1074919001877	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1074919001878	glutamine binding [chemical binding]; other site
1074919001879	catalytic triad [active]
1074919001880	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1074919001881	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1074919001882	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1074919001883	substrate-cofactor binding pocket; other site
1074919001884	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1074919001885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001886	catalytic residue [active]
1074919001887	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1074919001888	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1074919001889	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1074919001890	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1074919001891	Sulfatase; Region: Sulfatase; pfam00884
1074919001892	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1074919001893	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919001894	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919001895	ABC transporter; Region: ABC_tran_2; pfam12848
1074919001896	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919001897	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1074919001898	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919001899	ATP binding site [chemical binding]; other site
1074919001900	putative Mg++ binding site [ion binding]; other site
1074919001901	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919001902	nucleotide binding region [chemical binding]; other site
1074919001903	ATP-binding site [chemical binding]; other site
1074919001904	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1074919001905	HRDC domain; Region: HRDC; pfam00570
1074919001906	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1074919001907	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1074919001908	Walker A/P-loop; other site
1074919001909	ATP binding site [chemical binding]; other site
1074919001910	Q-loop/lid; other site
1074919001911	ABC transporter signature motif; other site
1074919001912	Walker B; other site
1074919001913	D-loop; other site
1074919001914	H-loop/switch region; other site
1074919001915	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1074919001916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919001917	dimer interface [polypeptide binding]; other site
1074919001918	conserved gate region; other site
1074919001919	ABC-ATPase subunit interface; other site
1074919001920	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1074919001921	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1074919001922	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1074919001923	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919001924	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001925	homodimer interface [polypeptide binding]; other site
1074919001926	catalytic residue [active]
1074919001927	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
1074919001928	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1074919001929	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1074919001930	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1074919001931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919001932	putative substrate translocation pore; other site
1074919001933	POT family; Region: PTR2; cl17359
1074919001934	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1074919001935	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1074919001936	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
1074919001937	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1074919001938	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1074919001939	active site
1074919001940	dimer interface [polypeptide binding]; other site
1074919001941	catalytic residues [active]
1074919001942	effector binding site; other site
1074919001943	R2 peptide binding site; other site
1074919001944	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1074919001945	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1074919001946	dimer interface [polypeptide binding]; other site
1074919001947	putative radical transfer pathway; other site
1074919001948	diiron center [ion binding]; other site
1074919001949	tyrosyl radical; other site
1074919001950	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001951	ABC-ATPase subunit  interface; other site
1074919001952	dimer interface [polypeptide binding]; other site
1074919001953	putative PBP binding regions; other site
1074919001954	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001955	ABC-ATPase subunit  interface; other site
1074919001956	dimer interface [polypeptide binding]; other site
1074919001957	putative PBP binding regions; other site
1074919001958	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1074919001959	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074919001960	Walker A/P-loop; other site
1074919001961	ATP binding site [chemical binding]; other site
1074919001962	Q-loop/lid; other site
1074919001963	ABC transporter signature motif; other site
1074919001964	Walker B; other site
1074919001965	D-loop; other site
1074919001966	H-loop/switch region; other site
1074919001967	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1074919001968	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1074919001969	putative ligand binding residues [chemical binding]; other site
1074919001970	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
1074919001971	FAD binding domain; Region: FAD_binding_4; pfam01565
1074919001972	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1074919001973	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1074919001974	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1074919001975	peptidase T; Region: peptidase-T; TIGR01882
1074919001976	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1074919001977	metal binding site [ion binding]; metal-binding site
1074919001978	dimer interface [polypeptide binding]; other site
1074919001979	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1074919001980	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1074919001981	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1074919001982	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1074919001983	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1074919001984	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1074919001985	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1074919001986	metal binding site [ion binding]; metal-binding site
1074919001987	active site
1074919001988	I-site; other site
1074919001989	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1074919001990	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1074919001991	Mg++ binding site [ion binding]; other site
1074919001992	putative catalytic motif [active]
1074919001993	substrate binding site [chemical binding]; other site
1074919001994	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1074919001995	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1074919001996	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1074919001997	EDD domain protein, DegV family; Region: DegV; TIGR00762
1074919001998	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1074919001999	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1074919002000	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919002001	ATP binding site [chemical binding]; other site
1074919002002	putative Mg++ binding site [ion binding]; other site
1074919002003	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919002004	nucleotide binding region [chemical binding]; other site
1074919002005	ATP-binding site [chemical binding]; other site
1074919002006	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1074919002007	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919002008	active site
1074919002009	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1074919002010	30S subunit binding site; other site
1074919002011	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1074919002012	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1074919002013	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1074919002014	nucleotide binding region [chemical binding]; other site
1074919002015	ATP-binding site [chemical binding]; other site
1074919002016	SEC-C motif; Region: SEC-C; pfam02810
1074919002017	peptide chain release factor 2; Provisional; Region: PRK06746
1074919002018	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1074919002019	RF-1 domain; Region: RF-1; pfam00472
1074919002020	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1074919002021	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919002022	Surface antigen [General function prediction only]; Region: COG3942
1074919002023	CHAP domain; Region: CHAP; pfam05257
1074919002024	HD domain; Region: HD_3; cl17350
1074919002025	excinuclease ABC subunit B; Provisional; Region: PRK05298
1074919002026	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919002027	ATP binding site [chemical binding]; other site
1074919002028	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919002029	nucleotide binding region [chemical binding]; other site
1074919002030	ATP-binding site [chemical binding]; other site
1074919002031	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1074919002032	UvrB/uvrC motif; Region: UVR; pfam02151
1074919002033	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1074919002034	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1074919002035	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1074919002036	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1074919002037	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1074919002038	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1074919002039	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1074919002040	Hpr binding site; other site
1074919002041	active site
1074919002042	homohexamer subunit interaction site [polypeptide binding]; other site
1074919002043	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1074919002044	putative acyl transferase; Provisional; Region: PRK10191
1074919002045	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1074919002046	trimer interface [polypeptide binding]; other site
1074919002047	active site
1074919002048	substrate binding site [chemical binding]; other site
1074919002049	CoA binding site [chemical binding]; other site
1074919002050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1074919002051	binding surface
1074919002052	TPR motif; other site
1074919002053	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919002054	TPR motif; other site
1074919002055	binding surface
1074919002056	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1074919002057	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919002058	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002059	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
1074919002060	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1074919002061	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
1074919002062	dimer interface [polypeptide binding]; other site
1074919002063	phosphate binding site [ion binding]; other site
1074919002064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1074919002065	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1074919002066	Clp protease; Region: CLP_protease; pfam00574
1074919002067	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1074919002068	oligomer interface [polypeptide binding]; other site
1074919002069	active site residues [active]
1074919002070	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1074919002071	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919002072	NAD(P) binding site [chemical binding]; other site
1074919002073	active site
1074919002074	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1074919002075	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1074919002076	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1074919002077	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1074919002078	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1074919002079	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1074919002080	Phosphoglycerate kinase; Region: PGK; pfam00162
1074919002081	substrate binding site [chemical binding]; other site
1074919002082	hinge regions; other site
1074919002083	ADP binding site [chemical binding]; other site
1074919002084	catalytic site [active]
1074919002085	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1074919002086	triosephosphate isomerase; Provisional; Region: PRK14565
1074919002087	substrate binding site [chemical binding]; other site
1074919002088	dimer interface [polypeptide binding]; other site
1074919002089	catalytic triad [active]
1074919002090	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1074919002091	phosphoglyceromutase; Provisional; Region: PRK05434
1074919002092	enolase; Provisional; Region: eno; PRK00077
1074919002093	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1074919002094	dimer interface [polypeptide binding]; other site
1074919002095	metal binding site [ion binding]; metal-binding site
1074919002096	substrate binding pocket [chemical binding]; other site
1074919002097	Esterase/lipase [General function prediction only]; Region: COG1647
1074919002098	ribonuclease R; Region: RNase_R; TIGR02063
1074919002099	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1074919002100	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1074919002101	RNB domain; Region: RNB; pfam00773
1074919002102	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1074919002103	RNA binding site [nucleotide binding]; other site
1074919002104	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919002105	Coenzyme A binding pocket [chemical binding]; other site
1074919002106	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1074919002107	MULE transposase domain; Region: MULE; pfam10551
1074919002108	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919002109	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1074919002110	Staphylococcal nuclease homologues; Region: SNc; smart00318
1074919002111	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1074919002112	Catalytic site; other site
1074919002113	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
1074919002114	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074919002115	catalytic core [active]
1074919002116	Lysine efflux permease [General function prediction only]; Region: COG1279
1074919002117	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919002118	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1074919002119	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919002120	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1074919002121	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1074919002122	active site
1074919002123	catalytic residue [active]
1074919002124	dimer interface [polypeptide binding]; other site
1074919002125	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1074919002126	putative FMN binding site [chemical binding]; other site
1074919002127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
1074919002128	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919002129	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1074919002130	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1074919002131	Int/Topo IB signature motif; other site
1074919002132	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919002133	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919002134	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919002135	active site
1074919002136	DNA binding site [nucleotide binding]
1074919002137	Int/Topo IB signature motif; other site
1074919002138	aminoglycoside resistance protein; Provisional; Region: PRK13746
1074919002139	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1074919002140	active site
1074919002141	NTP binding site [chemical binding]; other site
1074919002142	metal binding triad [ion binding]; metal-binding site
1074919002143	antibiotic binding site [chemical binding]; other site
1074919002144	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1074919002145	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1074919002146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919002147	S-adenosylmethionine binding site [chemical binding]; other site
1074919002148	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919002149	S-adenosylmethionine binding site [chemical binding]; other site
1074919002150	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1074919002151	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1074919002152	Walker A/P-loop; other site
1074919002153	ATP binding site [chemical binding]; other site
1074919002154	Q-loop/lid; other site
1074919002155	ABC transporter signature motif; other site
1074919002156	Walker B; other site
1074919002157	D-loop; other site
1074919002158	H-loop/switch region; other site
1074919002159	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1074919002160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002161	dimer interface [polypeptide binding]; other site
1074919002162	conserved gate region; other site
1074919002163	ABC-ATPase subunit interface; other site
1074919002164	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1074919002165	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1074919002166	Predicted membrane protein [Function unknown]; Region: COG2035
1074919002167	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1074919002168	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1074919002169	Walker A/P-loop; other site
1074919002170	ATP binding site [chemical binding]; other site
1074919002171	Q-loop/lid; other site
1074919002172	ABC transporter signature motif; other site
1074919002173	Walker B; other site
1074919002174	D-loop; other site
1074919002175	H-loop/switch region; other site
1074919002176	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1074919002177	FeS assembly protein SufD; Region: sufD; TIGR01981
1074919002178	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1074919002179	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1074919002180	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919002181	catalytic residue [active]
1074919002182	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1074919002183	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1074919002184	trimerization site [polypeptide binding]; other site
1074919002185	active site
1074919002186	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1074919002187	FeS assembly protein SufB; Region: sufB; TIGR01980
1074919002188	Domain of unknown function DUF21; Region: DUF21; pfam01595
1074919002189	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1074919002190	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1074919002191	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1074919002192	FMN binding site [chemical binding]; other site
1074919002193	substrate binding site [chemical binding]; other site
1074919002194	putative catalytic residue [active]
1074919002195	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1074919002196	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1074919002197	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1074919002198	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1074919002199	active site
1074919002200	metal binding site [ion binding]; metal-binding site
1074919002201	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1074919002202	lipoyl synthase; Provisional; Region: PRK05481
1074919002203	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919002204	FeS/SAM binding site; other site
1074919002205	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919002206	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919002207	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1074919002208	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919002209	active site
1074919002210	motif I; other site
1074919002211	motif II; other site
1074919002212	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919002213	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1074919002214	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1074919002215	dimerization interface [polypeptide binding]; other site
1074919002216	ligand binding site [chemical binding]; other site
1074919002217	NADP binding site [chemical binding]; other site
1074919002218	catalytic site [active]
1074919002219	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1074919002220	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1074919002221	acyl-activating enzyme (AAE) consensus motif; other site
1074919002222	AMP binding site [chemical binding]; other site
1074919002223	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1074919002224	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1074919002225	DltD N-terminal region; Region: DltD_N; pfam04915
1074919002226	DltD central region; Region: DltD_M; pfam04918
1074919002227	DltD C-terminal region; Region: DltD_C; pfam04914
1074919002228	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1074919002229	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002230	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1074919002231	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002232	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
1074919002233	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1074919002234	interface (dimer of trimers) [polypeptide binding]; other site
1074919002235	Substrate-binding/catalytic site; other site
1074919002236	Zn-binding sites [ion binding]; other site
1074919002237	Predicted permease [General function prediction only]; Region: COG2056
1074919002238	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1074919002239	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1074919002240	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919002241	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1074919002242	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
1074919002243	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
1074919002244	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919002245	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
1074919002246	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919002247	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1074919002248	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1074919002249	active site
1074919002250	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1074919002251	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1074919002252	putative active site [active]
1074919002253	putative FMN binding site [chemical binding]; other site
1074919002254	putative substrate binding site [chemical binding]; other site
1074919002255	putative catalytic residue [active]
1074919002256	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1074919002257	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919002258	inhibitor-cofactor binding pocket; inhibition site
1074919002259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919002260	catalytic residue [active]
1074919002261	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1074919002262	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1074919002263	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1074919002264	NAD(P) binding site [chemical binding]; other site
1074919002265	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919002266	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1074919002267	active site
1074919002268	catalytic site [active]
1074919002269	metal binding site [ion binding]; metal-binding site
1074919002270	Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165
1074919002271	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1074919002272	active sites [active]
1074919002273	tetramer interface [polypeptide binding]; other site
1074919002274	argininosuccinate synthase; Provisional; Region: PRK13820
1074919002275	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1074919002276	ANP binding site [chemical binding]; other site
1074919002277	Substrate Binding Site II [chemical binding]; other site
1074919002278	Substrate Binding Site I [chemical binding]; other site
1074919002279	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1074919002280	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1074919002281	active site
1074919002282	dimer interface [polypeptide binding]; other site
1074919002283	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1074919002284	dimer interface [polypeptide binding]; other site
1074919002285	active site
1074919002286	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1074919002287	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1074919002288	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1074919002289	Catalytic site [active]
1074919002290	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1074919002291	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1074919002292	Catalytic site [active]
1074919002293	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1074919002294	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1074919002295	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1074919002296	Part of AAA domain; Region: AAA_19; pfam13245
1074919002297	Family description; Region: UvrD_C_2; pfam13538
1074919002298	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1074919002299	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1074919002300	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1074919002301	coenzyme A disulfide reductase; Provisional; Region: PRK13512
1074919002302	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919002303	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002304	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074919002305	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1074919002306	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919002307	active site
1074919002308	motif I; other site
1074919002309	motif II; other site
1074919002310	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919002311	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1074919002312	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1074919002313	catalytic triad [active]
1074919002314	catalytic triad [active]
1074919002315	oxyanion hole [active]
1074919002316	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1074919002317	Clp amino terminal domain; Region: Clp_N; pfam02861
1074919002318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919002319	Walker A motif; other site
1074919002320	ATP binding site [chemical binding]; other site
1074919002321	Walker B motif; other site
1074919002322	arginine finger; other site
1074919002323	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1074919002324	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919002325	Walker A motif; other site
1074919002326	ATP binding site [chemical binding]; other site
1074919002327	Walker B motif; other site
1074919002328	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1074919002329	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919002330	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919002331	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1074919002332	dimerization interface [polypeptide binding]; other site
1074919002333	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1074919002334	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1074919002335	active site
1074919002336	catalytic residues [active]
1074919002337	metal binding site [ion binding]; metal-binding site
1074919002338	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1074919002339	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1074919002340	substrate binding site [chemical binding]; other site
1074919002341	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1074919002342	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1074919002343	dimer interface [polypeptide binding]; other site
1074919002344	active site
1074919002345	CoA binding pocket [chemical binding]; other site
1074919002346	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1074919002347	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1074919002348	dimer interface [polypeptide binding]; other site
1074919002349	active site
1074919002350	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919002351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002352	dimer interface [polypeptide binding]; other site
1074919002353	conserved gate region; other site
1074919002354	putative PBP binding loops; other site
1074919002355	ABC-ATPase subunit interface; other site
1074919002356	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1074919002357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002358	dimer interface [polypeptide binding]; other site
1074919002359	conserved gate region; other site
1074919002360	putative PBP binding loops; other site
1074919002361	ABC-ATPase subunit interface; other site
1074919002362	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1074919002363	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919002364	Walker A/P-loop; other site
1074919002365	ATP binding site [chemical binding]; other site
1074919002366	Q-loop/lid; other site
1074919002367	ABC transporter signature motif; other site
1074919002368	Walker B; other site
1074919002369	D-loop; other site
1074919002370	H-loop/switch region; other site
1074919002371	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074919002372	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1074919002373	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919002374	Walker A/P-loop; other site
1074919002375	ATP binding site [chemical binding]; other site
1074919002376	Q-loop/lid; other site
1074919002377	ABC transporter signature motif; other site
1074919002378	Walker B; other site
1074919002379	D-loop; other site
1074919002380	H-loop/switch region; other site
1074919002381	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074919002382	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1074919002383	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1074919002384	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1074919002385	peptide binding site [polypeptide binding]; other site
1074919002386	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074919002387	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
1074919002388	peptide binding site [polypeptide binding]; other site
1074919002389	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1074919002390	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919002391	Walker A/P-loop; other site
1074919002392	ATP binding site [chemical binding]; other site
1074919002393	Q-loop/lid; other site
1074919002394	ABC transporter signature motif; other site
1074919002395	Walker B; other site
1074919002396	D-loop; other site
1074919002397	H-loop/switch region; other site
1074919002398	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074919002399	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1074919002400	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919002401	Walker A/P-loop; other site
1074919002402	ATP binding site [chemical binding]; other site
1074919002403	Q-loop/lid; other site
1074919002404	ABC transporter signature motif; other site
1074919002405	Walker B; other site
1074919002406	D-loop; other site
1074919002407	H-loop/switch region; other site
1074919002408	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1074919002409	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919002410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002411	dimer interface [polypeptide binding]; other site
1074919002412	conserved gate region; other site
1074919002413	putative PBP binding loops; other site
1074919002414	ABC-ATPase subunit interface; other site
1074919002415	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1074919002416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002417	dimer interface [polypeptide binding]; other site
1074919002418	conserved gate region; other site
1074919002419	putative PBP binding loops; other site
1074919002420	ABC-ATPase subunit interface; other site
1074919002421	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1074919002422	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1074919002423	active site
1074919002424	HIGH motif; other site
1074919002425	dimer interface [polypeptide binding]; other site
1074919002426	KMSKS motif; other site
1074919002427	adaptor protein; Provisional; Region: PRK02315
1074919002428	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
1074919002429	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1074919002430	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1074919002431	active site
1074919002432	Zn binding site [ion binding]; other site
1074919002433	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1074919002434	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1074919002435	catalytic residues [active]
1074919002436	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1074919002437	putative active site [active]
1074919002438	putative metal binding residues [ion binding]; other site
1074919002439	signature motif; other site
1074919002440	putative triphosphate binding site [ion binding]; other site
1074919002441	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1074919002442	synthetase active site [active]
1074919002443	NTP binding site [chemical binding]; other site
1074919002444	metal binding site [ion binding]; metal-binding site
1074919002445	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1074919002446	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1074919002447	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1074919002448	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1074919002449	active site
1074919002450	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1074919002451	MgtE intracellular N domain; Region: MgtE_N; smart00924
1074919002452	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1074919002453	Divalent cation transporter; Region: MgtE; pfam01769
1074919002454	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1074919002455	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1074919002456	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1074919002457	TrkA-N domain; Region: TrkA_N; pfam02254
1074919002458	TrkA-C domain; Region: TrkA_C; pfam02080
1074919002459	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1074919002460	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1074919002461	NAD binding site [chemical binding]; other site
1074919002462	homotetramer interface [polypeptide binding]; other site
1074919002463	homodimer interface [polypeptide binding]; other site
1074919002464	substrate binding site [chemical binding]; other site
1074919002465	active site
1074919002466	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1074919002467	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1074919002468	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1074919002469	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1074919002470	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1074919002471	Putative esterase; Region: Esterase; pfam00756
1074919002472	hypothetical protein; Provisional; Region: PRK13679
1074919002473	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1074919002474	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919002475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919002476	putative substrate translocation pore; other site
1074919002477	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
1074919002478	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1074919002479	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1074919002480	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1074919002481	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1074919002482	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919002483	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919002484	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1074919002485	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1074919002486	G1 box; other site
1074919002487	putative GEF interaction site [polypeptide binding]; other site
1074919002488	GTP/Mg2+ binding site [chemical binding]; other site
1074919002489	Switch I region; other site
1074919002490	G2 box; other site
1074919002491	G3 box; other site
1074919002492	Switch II region; other site
1074919002493	G4 box; other site
1074919002494	G5 box; other site
1074919002495	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1074919002496	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1074919002497	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1074919002498	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1074919002499	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1074919002500	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1074919002501	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1074919002502	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1074919002503	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1074919002504	active site
1074919002505	metal binding site [ion binding]; metal-binding site
1074919002506	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1074919002507	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
1074919002508	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1074919002509	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1074919002510	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1074919002511	CAAX protease self-immunity; Region: Abi; pfam02517
1074919002512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
1074919002513	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
1074919002514	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919002515	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1074919002516	Walker A/P-loop; other site
1074919002517	ATP binding site [chemical binding]; other site
1074919002518	Q-loop/lid; other site
1074919002519	ABC transporter signature motif; other site
1074919002520	Walker B; other site
1074919002521	D-loop; other site
1074919002522	H-loop/switch region; other site
1074919002523	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1074919002524	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1074919002525	siderophore binding site; other site
1074919002526	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919002527	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919002528	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919002529	Coenzyme A binding pocket [chemical binding]; other site
1074919002530	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1074919002531	UbiA prenyltransferase family; Region: UbiA; pfam01040
1074919002532	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1074919002533	isochorismate synthases; Region: isochor_syn; TIGR00543
1074919002534	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1074919002535	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1074919002536	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1074919002537	TPP-binding site; other site
1074919002538	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1074919002539	PGAP1-like protein; Region: PGAP1; pfam07819
1074919002540	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1074919002541	substrate binding site [chemical binding]; other site
1074919002542	oxyanion hole (OAH) forming residues; other site
1074919002543	trimer interface [polypeptide binding]; other site
1074919002544	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1074919002545	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919002546	aminotransferase A; Validated; Region: PRK07683
1074919002547	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919002548	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919002549	homodimer interface [polypeptide binding]; other site
1074919002550	catalytic residue [active]
1074919002551	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1074919002552	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1074919002553	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1074919002554	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1074919002555	amidase catalytic site [active]
1074919002556	Zn binding residues [ion binding]; other site
1074919002557	substrate binding site [chemical binding]; other site
1074919002558	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1074919002559	Lysozyme subfamily 2; Region: LYZ2; smart00047
1074919002560	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919002561	Coenzyme A binding pocket [chemical binding]; other site
1074919002562	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
1074919002563	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1074919002564	Beta-lactamase; Region: Beta-lactamase; pfam00144
1074919002565	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1074919002566	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1074919002567	Subunit III/IV interface [polypeptide binding]; other site
1074919002568	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1074919002569	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1074919002570	D-pathway; other site
1074919002571	Putative ubiquinol binding site [chemical binding]; other site
1074919002572	Low-spin heme (heme b) binding site [chemical binding]; other site
1074919002573	Putative water exit pathway; other site
1074919002574	Binuclear center (heme o3/CuB) [ion binding]; other site
1074919002575	K-pathway; other site
1074919002576	Putative proton exit pathway; other site
1074919002577	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1074919002578	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1074919002579	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1074919002580	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
1074919002581	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1074919002582	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1074919002583	homodimer interface [polypeptide binding]; other site
1074919002584	NADP binding site [chemical binding]; other site
1074919002585	substrate binding site [chemical binding]; other site
1074919002586	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1074919002587	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1074919002588	ATP-grasp domain; Region: ATP-grasp; pfam02222
1074919002589	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1074919002590	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1074919002591	ATP binding site [chemical binding]; other site
1074919002592	active site
1074919002593	substrate binding site [chemical binding]; other site
1074919002594	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1074919002595	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1074919002596	putative active site [active]
1074919002597	catalytic triad [active]
1074919002598	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1074919002599	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1074919002600	dimerization interface [polypeptide binding]; other site
1074919002601	ATP binding site [chemical binding]; other site
1074919002602	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1074919002603	dimerization interface [polypeptide binding]; other site
1074919002604	ATP binding site [chemical binding]; other site
1074919002605	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1074919002606	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1074919002607	tetramer interface [polypeptide binding]; other site
1074919002608	active site
1074919002609	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919002610	active site
1074919002611	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1074919002612	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1074919002613	dimerization interface [polypeptide binding]; other site
1074919002614	putative ATP binding site [chemical binding]; other site
1074919002615	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
1074919002616	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1074919002617	active site
1074919002618	substrate binding site [chemical binding]; other site
1074919002619	cosubstrate binding site; other site
1074919002620	catalytic site [active]
1074919002621	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1074919002622	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1074919002623	purine monophosphate binding site [chemical binding]; other site
1074919002624	dimer interface [polypeptide binding]; other site
1074919002625	putative catalytic residues [active]
1074919002626	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1074919002627	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1074919002628	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1074919002629	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
1074919002630	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1074919002631	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1074919002632	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1074919002633	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919002634	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919002635	Walker A/P-loop; other site
1074919002636	ATP binding site [chemical binding]; other site
1074919002637	Q-loop/lid; other site
1074919002638	ABC transporter signature motif; other site
1074919002639	Walker B; other site
1074919002640	D-loop; other site
1074919002641	H-loop/switch region; other site
1074919002642	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
1074919002643	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919002644	Walker A/P-loop; other site
1074919002645	ATP binding site [chemical binding]; other site
1074919002646	Q-loop/lid; other site
1074919002647	ABC transporter signature motif; other site
1074919002648	Walker B; other site
1074919002649	D-loop; other site
1074919002650	H-loop/switch region; other site
1074919002651	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
1074919002652	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1074919002653	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1074919002654	putative RNA binding site [nucleotide binding]; other site
1074919002655	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1074919002656	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1074919002657	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1074919002658	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1074919002659	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1074919002660	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1074919002661	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1074919002662	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1074919002663	TrkA-N domain; Region: TrkA_N; pfam02254
1074919002664	TrkA-C domain; Region: TrkA_C; pfam02080
1074919002665	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1074919002666	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1074919002667	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1074919002668	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1074919002669	active site
1074919002670	catalytic residues [active]
1074919002671	metal binding site [ion binding]; metal-binding site
1074919002672	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1074919002673	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1074919002674	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1074919002675	TPP-binding site [chemical binding]; other site
1074919002676	tetramer interface [polypeptide binding]; other site
1074919002677	heterodimer interface [polypeptide binding]; other site
1074919002678	phosphorylation loop region [posttranslational modification]
1074919002679	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1074919002680	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1074919002681	alpha subunit interface [polypeptide binding]; other site
1074919002682	TPP binding site [chemical binding]; other site
1074919002683	heterodimer interface [polypeptide binding]; other site
1074919002684	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1074919002685	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1074919002686	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1074919002687	E3 interaction surface; other site
1074919002688	lipoyl attachment site [posttranslational modification]; other site
1074919002689	e3 binding domain; Region: E3_binding; pfam02817
1074919002690	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1074919002691	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1074919002692	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074919002693	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002694	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074919002695	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074919002696	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919002697	non-specific DNA binding site [nucleotide binding]; other site
1074919002698	salt bridge; other site
1074919002699	sequence-specific DNA binding site [nucleotide binding]; other site
1074919002700	Cupin domain; Region: Cupin_2; pfam07883
1074919002701	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1074919002702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919002703	Walker A/P-loop; other site
1074919002704	ATP binding site [chemical binding]; other site
1074919002705	Q-loop/lid; other site
1074919002706	ABC transporter signature motif; other site
1074919002707	Walker B; other site
1074919002708	D-loop; other site
1074919002709	H-loop/switch region; other site
1074919002710	TOBE domain; Region: TOBE_2; pfam08402
1074919002711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1074919002712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002713	putative PBP binding loops; other site
1074919002714	dimer interface [polypeptide binding]; other site
1074919002715	ABC-ATPase subunit interface; other site
1074919002716	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1074919002717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002718	dimer interface [polypeptide binding]; other site
1074919002719	conserved gate region; other site
1074919002720	putative PBP binding loops; other site
1074919002721	ABC-ATPase subunit interface; other site
1074919002722	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1074919002723	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
1074919002724	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1074919002725	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1074919002726	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1074919002727	manganese transport protein MntH; Reviewed; Region: PRK00701
1074919002728	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1074919002729	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1074919002730	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1074919002731	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1074919002732	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1074919002733	active site
1074919002734	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1074919002735	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1074919002736	G1 box; other site
1074919002737	putative GEF interaction site [polypeptide binding]; other site
1074919002738	GTP/Mg2+ binding site [chemical binding]; other site
1074919002739	Switch I region; other site
1074919002740	G2 box; other site
1074919002741	G3 box; other site
1074919002742	Switch II region; other site
1074919002743	G4 box; other site
1074919002744	G5 box; other site
1074919002745	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1074919002746	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1074919002747	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1074919002748	pyruvate carboxylase; Reviewed; Region: PRK12999
1074919002749	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919002750	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1074919002751	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1074919002752	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1074919002753	active site
1074919002754	catalytic residues [active]
1074919002755	metal binding site [ion binding]; metal-binding site
1074919002756	homodimer binding site [polypeptide binding]; other site
1074919002757	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1074919002758	carboxyltransferase (CT) interaction site; other site
1074919002759	biotinylation site [posttranslational modification]; other site
1074919002760	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1074919002761	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1074919002762	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1074919002763	UbiA prenyltransferase family; Region: UbiA; pfam01040
1074919002764	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1074919002765	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1074919002766	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919002767	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1074919002768	putative active site [active]
1074919002769	catalytic site [active]
1074919002770	putative metal binding site [ion binding]; other site
1074919002771	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1074919002772	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919002773	S-adenosylmethionine binding site [chemical binding]; other site
1074919002774	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1074919002775	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1074919002776	active site
1074919002777	(T/H)XGH motif; other site
1074919002778	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
1074919002779	hypothetical protein; Provisional; Region: PRK13670
1074919002780	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1074919002781	heme uptake protein IsdB; Region: IsdB; TIGR03657
1074919002782	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919002783	NEAr Transporter domain; Region: NEAT; smart00725
1074919002784	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1074919002785	heme-binding site [chemical binding]; other site
1074919002786	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1074919002787	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
1074919002788	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1074919002789	heme-binding site [chemical binding]; other site
1074919002790	heme uptake protein IsdC; Region: IsdC; TIGR03656
1074919002791	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1074919002792	heme-binding site [chemical binding]; other site
1074919002793	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
1074919002794	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074919002795	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1074919002796	intersubunit interface [polypeptide binding]; other site
1074919002797	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074919002798	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919002799	ABC-ATPase subunit  interface; other site
1074919002800	dimer interface [polypeptide binding]; other site
1074919002801	putative PBP binding regions; other site
1074919002802	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1074919002803	active site
1074919002804	catalytic site [active]
1074919002805	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1074919002806	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1074919002807	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1074919002808	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1074919002809	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1074919002810	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1074919002811	dimer interface [polypeptide binding]; other site
1074919002812	motif 1; other site
1074919002813	active site
1074919002814	motif 2; other site
1074919002815	motif 3; other site
1074919002816	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1074919002817	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1074919002818	putative tRNA-binding site [nucleotide binding]; other site
1074919002819	B3/4 domain; Region: B3_4; pfam03483
1074919002820	tRNA synthetase B5 domain; Region: B5; smart00874
1074919002821	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1074919002822	dimer interface [polypeptide binding]; other site
1074919002823	motif 1; other site
1074919002824	motif 3; other site
1074919002825	motif 2; other site
1074919002826	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1074919002827	ribonuclease HIII; Provisional; Region: PRK00996
1074919002828	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1074919002829	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1074919002830	RNA/DNA hybrid binding site [nucleotide binding]; other site
1074919002831	active site
1074919002832	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1074919002833	Colicin V production protein; Region: Colicin_V; pfam02674
1074919002834	hypothetical protein; Provisional; Region: PRK08609
1074919002835	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1074919002836	active site
1074919002837	primer binding site [nucleotide binding]; other site
1074919002838	NTP  binding site [chemical binding]; other site
1074919002839	metal binding triad [ion binding]; metal-binding site
1074919002840	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1074919002841	active site
1074919002842	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1074919002843	MutS domain III; Region: MutS_III; pfam05192
1074919002844	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1074919002845	Walker A/P-loop; other site
1074919002846	ATP binding site [chemical binding]; other site
1074919002847	Q-loop/lid; other site
1074919002848	ABC transporter signature motif; other site
1074919002849	Walker B; other site
1074919002850	D-loop; other site
1074919002851	H-loop/switch region; other site
1074919002852	Smr domain; Region: Smr; pfam01713
1074919002853	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1074919002854	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1074919002855	GIY-YIG motif/motif A; other site
1074919002856	active site
1074919002857	catalytic site [active]
1074919002858	putative DNA binding site [nucleotide binding]; other site
1074919002859	metal binding site [ion binding]; metal-binding site
1074919002860	UvrB/uvrC motif; Region: UVR; pfam02151
1074919002861	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1074919002862	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1074919002863	putative Iron-sulfur protein interface [polypeptide binding]; other site
1074919002864	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1074919002865	proximal heme binding site [chemical binding]; other site
1074919002866	distal heme binding site [chemical binding]; other site
1074919002867	putative dimer interface [polypeptide binding]; other site
1074919002868	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1074919002869	L-aspartate oxidase; Provisional; Region: PRK06175
1074919002870	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1074919002871	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1074919002872	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1074919002873	glutamate racemase; Provisional; Region: PRK00865
1074919002874	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1074919002875	active site
1074919002876	dimerization interface [polypeptide binding]; other site
1074919002877	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1074919002878	active site
1074919002879	metal binding site [ion binding]; metal-binding site
1074919002880	homotetramer interface [polypeptide binding]; other site
1074919002881	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1074919002882	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919002883	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919002884	beta-channel forming cytolysin; Region: hlyII; TIGR01002
1074919002885	superantigen-like protein; Reviewed; Region: PRK13350
1074919002886	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919002887	superantigen-like protein; Reviewed; Region: PRK13349
1074919002888	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919002889	superantigen-like protein; Reviewed; Region: PRK13043
1074919002890	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919002891	ornithine carbamoyltransferase; Provisional; Region: PRK04284
1074919002892	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1074919002893	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1074919002894	carbamate kinase; Reviewed; Region: PRK12686
1074919002895	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1074919002896	putative substrate binding site [chemical binding]; other site
1074919002897	nucleotide binding site [chemical binding]; other site
1074919002898	nucleotide binding site [chemical binding]; other site
1074919002899	homodimer interface [polypeptide binding]; other site
1074919002900	Predicted membrane protein [Function unknown]; Region: COG1288
1074919002901	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1074919002902	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1074919002903	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1074919002904	gating phenylalanine in ion channel; other site
1074919002905	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1074919002906	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919002907	motif II; other site
1074919002908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1074919002909	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1074919002910	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1074919002911	MraW methylase family; Region: Methyltransf_5; pfam01795
1074919002912	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1074919002913	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1074919002914	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1074919002915	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1074919002916	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1074919002917	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1074919002918	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1074919002919	Mg++ binding site [ion binding]; other site
1074919002920	putative catalytic motif [active]
1074919002921	putative substrate binding site [chemical binding]; other site
1074919002922	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1074919002923	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1074919002924	NAD binding site [chemical binding]; other site
1074919002925	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919002926	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919002927	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1074919002928	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1074919002929	Cell division protein FtsQ; Region: FtsQ; pfam03799
1074919002930	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1074919002931	Cell division protein FtsA; Region: FtsA; smart00842
1074919002932	Cell division protein FtsA; Region: FtsA; pfam14450
1074919002933	cell division protein FtsZ; Validated; Region: PRK09330
1074919002934	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1074919002935	nucleotide binding site [chemical binding]; other site
1074919002936	SulA interaction site; other site
1074919002937	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1074919002938	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1074919002939	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1074919002940	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919002941	catalytic residue [active]
1074919002942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1074919002943	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1074919002944	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919002945	RNA binding surface [nucleotide binding]; other site
1074919002946	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1074919002947	DivIVA domain; Region: DivI1A_domain; TIGR03544
1074919002948	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1074919002949	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1074919002950	HIGH motif; other site
1074919002951	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1074919002952	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1074919002953	active site
1074919002954	KMSKS motif; other site
1074919002955	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1074919002956	tRNA binding surface [nucleotide binding]; other site
1074919002957	anticodon binding site; other site
1074919002958	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1074919002959	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1074919002960	lipoprotein signal peptidase; Provisional; Region: PRK14787
1074919002961	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1074919002962	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919002963	RNA binding surface [nucleotide binding]; other site
1074919002964	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1074919002965	active site
1074919002966	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1074919002967	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
1074919002968	uracil transporter; Provisional; Region: PRK10720
1074919002969	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1074919002970	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1074919002971	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1074919002972	dihydroorotase; Validated; Region: pyrC; PRK09357
1074919002973	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1074919002974	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1074919002975	active site
1074919002976	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1074919002977	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1074919002978	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1074919002979	catalytic site [active]
1074919002980	subunit interface [polypeptide binding]; other site
1074919002981	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1074919002982	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919002983	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1074919002984	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1074919002985	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919002986	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074919002987	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1074919002988	IMP binding site; other site
1074919002989	dimer interface [polypeptide binding]; other site
1074919002990	interdomain contacts; other site
1074919002991	partial ornithine binding site; other site
1074919002992	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1074919002993	active site
1074919002994	dimer interface [polypeptide binding]; other site
1074919002995	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919002996	active site
1074919002997	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1074919002998	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1074919002999	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1074919003000	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1074919003001	catalytic site [active]
1074919003002	G-X2-G-X-G-K; other site
1074919003003	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1074919003004	Flavoprotein; Region: Flavoprotein; pfam02441
1074919003005	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1074919003006	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1074919003007	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919003008	ATP binding site [chemical binding]; other site
1074919003009	putative Mg++ binding site [ion binding]; other site
1074919003010	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1074919003011	nucleotide binding region [chemical binding]; other site
1074919003012	ATP-binding site [chemical binding]; other site
1074919003013	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1074919003014	active site
1074919003015	catalytic residues [active]
1074919003016	metal binding site [ion binding]; metal-binding site
1074919003017	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1074919003018	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1074919003019	putative active site [active]
1074919003020	substrate binding site [chemical binding]; other site
1074919003021	putative cosubstrate binding site; other site
1074919003022	catalytic site [active]
1074919003023	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1074919003024	substrate binding site [chemical binding]; other site
1074919003025	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1074919003026	NusB family; Region: NusB; pfam01029
1074919003027	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919003028	S-adenosylmethionine binding site [chemical binding]; other site
1074919003029	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1074919003030	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919003031	FeS/SAM binding site; other site
1074919003032	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1074919003033	Protein phosphatase 2C; Region: PP2C; pfam00481
1074919003034	active site
1074919003035	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1074919003036	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1074919003037	active site
1074919003038	ATP binding site [chemical binding]; other site
1074919003039	substrate binding site [chemical binding]; other site
1074919003040	activation loop (A-loop); other site
1074919003041	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1074919003042	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074919003043	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074919003044	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074919003045	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1074919003046	RNA binding site [nucleotide binding]; other site
1074919003047	Predicted GTPases [General function prediction only]; Region: COG1162
1074919003048	homodimer interface [polypeptide binding]; other site
1074919003049	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1074919003050	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1074919003051	GTP/Mg2+ binding site [chemical binding]; other site
1074919003052	G4 box; other site
1074919003053	G5 box; other site
1074919003054	G1 box; other site
1074919003055	Switch I region; other site
1074919003056	G2 box; other site
1074919003057	G3 box; other site
1074919003058	Switch II region; other site
1074919003059	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1074919003060	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1074919003061	substrate binding site [chemical binding]; other site
1074919003062	hexamer interface [polypeptide binding]; other site
1074919003063	metal binding site [ion binding]; metal-binding site
1074919003064	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1074919003065	Thiamine pyrophosphokinase; Region: TPK; cd07995
1074919003066	active site
1074919003067	dimerization interface [polypeptide binding]; other site
1074919003068	thiamine binding site [chemical binding]; other site
1074919003069	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
1074919003070	DAK2 domain; Region: Dak2; pfam02734
1074919003071	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1074919003072	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1074919003073	generic binding surface II; other site
1074919003074	ssDNA binding site; other site
1074919003075	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919003076	ATP binding site [chemical binding]; other site
1074919003077	putative Mg++ binding site [ion binding]; other site
1074919003078	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919003079	nucleotide binding region [chemical binding]; other site
1074919003080	ATP-binding site [chemical binding]; other site
1074919003081	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1074919003082	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1074919003083	active site 2 [active]
1074919003084	active site 1 [active]
1074919003085	putative phosphate acyltransferase; Provisional; Region: PRK05331
1074919003086	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1074919003087	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1074919003088	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1074919003089	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1074919003090	NAD(P) binding site [chemical binding]; other site
1074919003091	homotetramer interface [polypeptide binding]; other site
1074919003092	homodimer interface [polypeptide binding]; other site
1074919003093	active site
1074919003094	ribonuclease III; Reviewed; Region: rnc; PRK00102
1074919003095	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1074919003096	dimerization interface [polypeptide binding]; other site
1074919003097	active site
1074919003098	metal binding site [ion binding]; metal-binding site
1074919003099	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1074919003100	dsRNA binding site [nucleotide binding]; other site
1074919003101	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1074919003102	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1074919003103	Walker A/P-loop; other site
1074919003104	ATP binding site [chemical binding]; other site
1074919003105	Q-loop/lid; other site
1074919003106	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1074919003107	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1074919003108	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1074919003109	ABC transporter signature motif; other site
1074919003110	Walker B; other site
1074919003111	D-loop; other site
1074919003112	H-loop/switch region; other site
1074919003113	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1074919003114	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1074919003115	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1074919003116	P loop; other site
1074919003117	GTP binding site [chemical binding]; other site
1074919003118	signal recognition particle protein; Provisional; Region: PRK10867
1074919003119	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1074919003120	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1074919003121	P loop; other site
1074919003122	GTP binding site [chemical binding]; other site
1074919003123	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1074919003124	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1074919003125	RimM N-terminal domain; Region: RimM; pfam01782
1074919003126	PRC-barrel domain; Region: PRC; pfam05239
1074919003127	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1074919003128	Predicted membrane protein [Function unknown]; Region: COG4485
1074919003129	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1074919003130	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1074919003131	GTP/Mg2+ binding site [chemical binding]; other site
1074919003132	G4 box; other site
1074919003133	G5 box; other site
1074919003134	G1 box; other site
1074919003135	Switch I region; other site
1074919003136	G2 box; other site
1074919003137	G3 box; other site
1074919003138	Switch II region; other site
1074919003139	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1074919003140	RNA/DNA hybrid binding site [nucleotide binding]; other site
1074919003141	active site
1074919003142	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1074919003143	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1074919003144	CoA-ligase; Region: Ligase_CoA; pfam00549
1074919003145	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1074919003146	CoA binding domain; Region: CoA_binding; pfam02629
1074919003147	CoA-ligase; Region: Ligase_CoA; pfam00549
1074919003148	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1074919003149	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919003150	CHAP domain; Region: CHAP; pfam05257
1074919003151	FemAB family; Region: FemAB; pfam02388
1074919003152	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1074919003153	DNA protecting protein DprA; Region: dprA; TIGR00732
1074919003154	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1074919003155	DNA topoisomerase I; Validated; Region: PRK05582
1074919003156	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1074919003157	active site
1074919003158	interdomain interaction site; other site
1074919003159	putative metal-binding site [ion binding]; other site
1074919003160	nucleotide binding site [chemical binding]; other site
1074919003161	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1074919003162	domain I; other site
1074919003163	DNA binding groove [nucleotide binding]
1074919003164	phosphate binding site [ion binding]; other site
1074919003165	domain II; other site
1074919003166	domain III; other site
1074919003167	nucleotide binding site [chemical binding]; other site
1074919003168	catalytic site [active]
1074919003169	domain IV; other site
1074919003170	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1074919003171	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1074919003172	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1074919003173	Glucose inhibited division protein A; Region: GIDA; pfam01134
1074919003174	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919003175	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919003176	active site
1074919003177	DNA binding site [nucleotide binding]
1074919003178	Int/Topo IB signature motif; other site
1074919003179	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1074919003180	active site
1074919003181	HslU subunit interaction site [polypeptide binding]; other site
1074919003182	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1074919003183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919003184	Walker A motif; other site
1074919003185	ATP binding site [chemical binding]; other site
1074919003186	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1074919003187	Walker B motif; other site
1074919003188	arginine finger; other site
1074919003189	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1074919003190	transcriptional repressor CodY; Validated; Region: PRK04158
1074919003191	CodY GAF-like domain; Region: CodY; pfam06018
1074919003192	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1074919003193	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1074919003194	rRNA interaction site [nucleotide binding]; other site
1074919003195	S8 interaction site; other site
1074919003196	putative laminin-1 binding site; other site
1074919003197	elongation factor Ts; Provisional; Region: tsf; PRK09377
1074919003198	UBA/TS-N domain; Region: UBA; pfam00627
1074919003199	Elongation factor TS; Region: EF_TS; pfam00889
1074919003200	Elongation factor TS; Region: EF_TS; pfam00889
1074919003201	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1074919003202	putative nucleotide binding site [chemical binding]; other site
1074919003203	uridine monophosphate binding site [chemical binding]; other site
1074919003204	homohexameric interface [polypeptide binding]; other site
1074919003205	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1074919003206	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1074919003207	hinge region; other site
1074919003208	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1074919003209	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1074919003210	catalytic residue [active]
1074919003211	putative FPP diphosphate  binding site; other site
1074919003212	putative FPP binding hydrophobic cleft; other site
1074919003213	dimer interface [polypeptide binding]; other site
1074919003214	putative IPP diphosphate binding site; other site
1074919003215	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1074919003216	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1074919003217	RIP metalloprotease RseP; Region: TIGR00054
1074919003218	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1074919003219	active site
1074919003220	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1074919003221	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1074919003222	protein binding site [polypeptide binding]; other site
1074919003223	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1074919003224	putative substrate binding region [chemical binding]; other site
1074919003225	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1074919003226	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1074919003227	dimer interface [polypeptide binding]; other site
1074919003228	motif 1; other site
1074919003229	active site
1074919003230	motif 2; other site
1074919003231	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1074919003232	putative deacylase active site [active]
1074919003233	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1074919003234	active site
1074919003235	motif 3; other site
1074919003236	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1074919003237	anticodon binding site; other site
1074919003238	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1074919003239	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1074919003240	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1074919003241	generic binding surface II; other site
1074919003242	generic binding surface I; other site
1074919003243	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1074919003244	active site
1074919003245	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1074919003246	active site
1074919003247	catalytic site [active]
1074919003248	substrate binding site [chemical binding]; other site
1074919003249	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1074919003250	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1074919003251	Sm and related proteins; Region: Sm_like; cl00259
1074919003252	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1074919003253	putative oligomer interface [polypeptide binding]; other site
1074919003254	putative RNA binding site [nucleotide binding]; other site
1074919003255	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1074919003256	NusA N-terminal domain; Region: NusA_N; pfam08529
1074919003257	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1074919003258	RNA binding site [nucleotide binding]; other site
1074919003259	homodimer interface [polypeptide binding]; other site
1074919003260	NusA-like KH domain; Region: KH_5; pfam13184
1074919003261	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1074919003262	G-X-X-G motif; other site
1074919003263	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1074919003264	translation initiation factor IF-2; Region: IF-2; TIGR00487
1074919003265	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1074919003266	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1074919003267	G1 box; other site
1074919003268	putative GEF interaction site [polypeptide binding]; other site
1074919003269	GTP/Mg2+ binding site [chemical binding]; other site
1074919003270	Switch I region; other site
1074919003271	G2 box; other site
1074919003272	G3 box; other site
1074919003273	Switch II region; other site
1074919003274	G4 box; other site
1074919003275	G5 box; other site
1074919003276	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1074919003277	Translation-initiation factor 2; Region: IF-2; pfam11987
1074919003278	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1074919003279	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
1074919003280	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1074919003281	RNA binding site [nucleotide binding]; other site
1074919003282	active site
1074919003283	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
1074919003284	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1074919003285	active site
1074919003286	Riboflavin kinase; Region: Flavokinase; smart00904
1074919003287	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1074919003288	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1074919003289	RNase E interface [polypeptide binding]; other site
1074919003290	trimer interface [polypeptide binding]; other site
1074919003291	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1074919003292	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1074919003293	RNase E interface [polypeptide binding]; other site
1074919003294	trimer interface [polypeptide binding]; other site
1074919003295	active site
1074919003296	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1074919003297	putative nucleic acid binding region [nucleotide binding]; other site
1074919003298	G-X-X-G motif; other site
1074919003299	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1074919003300	RNA binding site [nucleotide binding]; other site
1074919003301	domain interface; other site
1074919003302	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1074919003303	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1074919003304	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1074919003305	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1074919003306	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1074919003307	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074919003308	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1074919003309	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1074919003310	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1074919003311	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1074919003312	DNA-binding site [nucleotide binding]; DNA binding site
1074919003313	UTRA domain; Region: UTRA; pfam07702
1074919003314	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1074919003315	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1074919003316	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1074919003317	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1074919003318	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1074919003319	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1074919003320	classical (c) SDRs; Region: SDR_c; cd05233
1074919003321	NAD(P) binding site [chemical binding]; other site
1074919003322	active site
1074919003323	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1074919003324	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1074919003325	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1074919003326	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1074919003327	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1074919003328	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1074919003329	putative MPT binding site; other site
1074919003330	recombinase A; Provisional; Region: recA; PRK09354
1074919003331	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1074919003332	hexamer interface [polypeptide binding]; other site
1074919003333	Walker A motif; other site
1074919003334	ATP binding site [chemical binding]; other site
1074919003335	Walker B motif; other site
1074919003336	phosphodiesterase; Provisional; Region: PRK12704
1074919003337	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919003338	Zn2+ binding site [ion binding]; other site
1074919003339	Mg2+ binding site [ion binding]; other site
1074919003340	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1074919003341	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1074919003342	putative active site [active]
1074919003343	metal binding site [ion binding]; metal-binding site
1074919003344	homodimer binding site [polypeptide binding]; other site
1074919003345	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1074919003346	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1074919003347	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1074919003348	dimer interface [polypeptide binding]; other site
1074919003349	PYR/PP interface [polypeptide binding]; other site
1074919003350	TPP binding site [chemical binding]; other site
1074919003351	substrate binding site [chemical binding]; other site
1074919003352	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1074919003353	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1074919003354	TPP-binding site [chemical binding]; other site
1074919003355	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1074919003356	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1074919003357	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1074919003358	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919003359	FeS/SAM binding site; other site
1074919003360	TRAM domain; Region: TRAM; pfam01938
1074919003361	Predicted membrane protein [Function unknown]; Region: COG4732
1074919003362	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1074919003363	MutS domain I; Region: MutS_I; pfam01624
1074919003364	MutS domain II; Region: MutS_II; pfam05188
1074919003365	MutS domain III; Region: MutS_III; pfam05192
1074919003366	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1074919003367	Walker A/P-loop; other site
1074919003368	ATP binding site [chemical binding]; other site
1074919003369	Q-loop/lid; other site
1074919003370	ABC transporter signature motif; other site
1074919003371	Walker B; other site
1074919003372	D-loop; other site
1074919003373	H-loop/switch region; other site
1074919003374	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1074919003375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919003376	ATP binding site [chemical binding]; other site
1074919003377	Mg2+ binding site [ion binding]; other site
1074919003378	G-X-G motif; other site
1074919003379	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1074919003380	ATP binding site [chemical binding]; other site
1074919003381	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1074919003382	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
1074919003383	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1074919003384	amphipathic channel; other site
1074919003385	Asn-Pro-Ala signature motifs; other site
1074919003386	glycerol kinase; Provisional; Region: glpK; PRK00047
1074919003387	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1074919003388	N- and C-terminal domain interface [polypeptide binding]; other site
1074919003389	active site
1074919003390	MgATP binding site [chemical binding]; other site
1074919003391	catalytic site [active]
1074919003392	metal binding site [ion binding]; metal-binding site
1074919003393	glycerol binding site [chemical binding]; other site
1074919003394	homotetramer interface [polypeptide binding]; other site
1074919003395	homodimer interface [polypeptide binding]; other site
1074919003396	FBP binding site [chemical binding]; other site
1074919003397	protein IIAGlc interface [polypeptide binding]; other site
1074919003398	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1074919003399	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1074919003400	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074919003401	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1074919003402	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1074919003403	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1074919003404	catalytic residues [active]
1074919003405	dimer interface [polypeptide binding]; other site
1074919003406	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1074919003407	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1074919003408	HflX GTPase family; Region: HflX; cd01878
1074919003409	G1 box; other site
1074919003410	GTP/Mg2+ binding site [chemical binding]; other site
1074919003411	Switch I region; other site
1074919003412	G2 box; other site
1074919003413	G3 box; other site
1074919003414	Switch II region; other site
1074919003415	G4 box; other site
1074919003416	G5 box; other site
1074919003417	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1074919003418	Aluminium resistance protein; Region: Alum_res; pfam06838
1074919003419	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1074919003420	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1074919003421	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1074919003422	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1074919003423	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1074919003424	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919003425	catalytic residue [active]
1074919003426	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1074919003427	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1074919003428	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1074919003429	putative active site [active]
1074919003430	catalytic site [active]
1074919003431	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1074919003432	putative active site [active]
1074919003433	catalytic site [active]
1074919003434	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074919003435	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919003436	Walker A/P-loop; other site
1074919003437	ATP binding site [chemical binding]; other site
1074919003438	Q-loop/lid; other site
1074919003439	ABC transporter signature motif; other site
1074919003440	Walker B; other site
1074919003441	D-loop; other site
1074919003442	H-loop/switch region; other site
1074919003443	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1074919003444	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074919003445	Histidine kinase; Region: HisKA_3; pfam07730
1074919003446	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1074919003447	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074919003448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919003449	active site
1074919003450	phosphorylation site [posttranslational modification]
1074919003451	intermolecular recognition site; other site
1074919003452	dimerization interface [polypeptide binding]; other site
1074919003453	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074919003454	DNA binding residues [nucleotide binding]
1074919003455	dimerization interface [polypeptide binding]; other site
1074919003456	Staphylococcal nuclease homologues; Region: SNc; smart00318
1074919003457	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1074919003458	Catalytic site; other site
1074919003459	AAA domain; Region: AAA_11; pfam13086
1074919003460	aspartate kinase; Reviewed; Region: PRK09034
1074919003461	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1074919003462	putative catalytic residues [active]
1074919003463	putative nucleotide binding site [chemical binding]; other site
1074919003464	putative aspartate binding site [chemical binding]; other site
1074919003465	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1074919003466	allosteric regulatory residue; other site
1074919003467	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1074919003468	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1074919003469	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1074919003470	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1074919003471	threonine synthase; Reviewed; Region: PRK06721
1074919003472	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1074919003473	homodimer interface [polypeptide binding]; other site
1074919003474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919003475	catalytic residue [active]
1074919003476	homoserine kinase; Provisional; Region: PRK01212
1074919003477	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1074919003478	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1074919003479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919003480	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1074919003481	active site
1074919003482	motif I; other site
1074919003483	motif II; other site
1074919003484	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1074919003485	lysine transporter; Provisional; Region: PRK10836
1074919003486	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1074919003487	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1074919003488	tetramer interface [polypeptide binding]; other site
1074919003489	heme binding pocket [chemical binding]; other site
1074919003490	NADPH binding site [chemical binding]; other site
1074919003491	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1074919003492	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1074919003493	active site
1074919003494	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1074919003495	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1074919003496	LexA repressor; Validated; Region: PRK00215
1074919003497	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1074919003498	putative DNA binding site [nucleotide binding]; other site
1074919003499	putative Zn2+ binding site [ion binding]; other site
1074919003500	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1074919003501	Catalytic site [active]
1074919003502	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1074919003503	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1074919003504	TPP-binding site [chemical binding]; other site
1074919003505	dimer interface [polypeptide binding]; other site
1074919003506	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1074919003507	PYR/PP interface [polypeptide binding]; other site
1074919003508	dimer interface [polypeptide binding]; other site
1074919003509	TPP binding site [chemical binding]; other site
1074919003510	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1074919003511	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
1074919003512	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1074919003513	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1074919003514	active site
1074919003515	metal binding site [ion binding]; metal-binding site
1074919003516	DNA binding site [nucleotide binding]
1074919003517	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1074919003518	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1074919003519	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1074919003520	Walker A/P-loop; other site
1074919003521	ATP binding site [chemical binding]; other site
1074919003522	Q-loop/lid; other site
1074919003523	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1074919003524	ABC transporter signature motif; other site
1074919003525	Walker B; other site
1074919003526	D-loop; other site
1074919003527	H-loop/switch region; other site
1074919003528	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1074919003529	aconitate hydratase; Validated; Region: PRK09277
1074919003530	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1074919003531	substrate binding site [chemical binding]; other site
1074919003532	ligand binding site [chemical binding]; other site
1074919003533	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1074919003534	substrate binding site [chemical binding]; other site
1074919003535	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1074919003536	active site
1074919003537	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1074919003538	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1074919003539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919003540	ATP binding site [chemical binding]; other site
1074919003541	Mg2+ binding site [ion binding]; other site
1074919003542	G-X-G motif; other site
1074919003543	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1074919003544	anchoring element; other site
1074919003545	dimer interface [polypeptide binding]; other site
1074919003546	ATP binding site [chemical binding]; other site
1074919003547	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1074919003548	active site
1074919003549	putative metal-binding site [ion binding]; other site
1074919003550	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1074919003551	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1074919003552	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1074919003553	CAP-like domain; other site
1074919003554	active site
1074919003555	primary dimer interface [polypeptide binding]; other site
1074919003556	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919003557	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1074919003558	amino acid carrier protein; Region: agcS; TIGR00835
1074919003559	CAT RNA binding domain; Region: CAT_RBD; smart01061
1074919003560	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919003561	PRD domain; Region: PRD; pfam00874
1074919003562	PRD domain; Region: PRD; pfam00874
1074919003563	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1074919003564	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1074919003565	Predicted integral membrane protein [Function unknown]; Region: COG0392
1074919003566	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1074919003567	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1074919003568	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1074919003569	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1074919003570	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1074919003571	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1074919003572	active site
1074919003573	DNA binding site [nucleotide binding]
1074919003574	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1074919003575	prephenate dehydrogenase; Validated; Region: PRK06545
1074919003576	prephenate dehydrogenase; Validated; Region: PRK08507
1074919003577	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1074919003578	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1074919003579	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1074919003580	putative oligomer interface [polypeptide binding]; other site
1074919003581	putative active site [active]
1074919003582	metal binding site [ion binding]; metal-binding site
1074919003583	anthranilate synthase component I; Provisional; Region: PRK13567
1074919003584	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1074919003585	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1074919003586	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1074919003587	glutamine binding [chemical binding]; other site
1074919003588	catalytic triad [active]
1074919003589	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1074919003590	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1074919003591	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1074919003592	active site
1074919003593	ribulose/triose binding site [chemical binding]; other site
1074919003594	phosphate binding site [ion binding]; other site
1074919003595	substrate (anthranilate) binding pocket [chemical binding]; other site
1074919003596	product (indole) binding pocket [chemical binding]; other site
1074919003597	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1074919003598	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1074919003599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919003600	catalytic residue [active]
1074919003601	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1074919003602	substrate binding site [chemical binding]; other site
1074919003603	active site
1074919003604	catalytic residues [active]
1074919003605	heterodimer interface [polypeptide binding]; other site
1074919003606	FemAB family; Region: FemAB; pfam02388
1074919003607	FlxA-like protein; Region: FlxA; pfam14282
1074919003608	FemAB family; Region: FemAB; pfam02388
1074919003609	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1074919003610	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919003611	active site
1074919003612	motif I; other site
1074919003613	motif II; other site
1074919003614	SWIM zinc finger; Region: SWIM; pfam04434
1074919003615	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919003616	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1074919003617	Walker A/P-loop; other site
1074919003618	ATP binding site [chemical binding]; other site
1074919003619	Q-loop/lid; other site
1074919003620	ABC transporter signature motif; other site
1074919003621	Walker B; other site
1074919003622	D-loop; other site
1074919003623	H-loop/switch region; other site
1074919003624	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1074919003625	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919003626	Walker A/P-loop; other site
1074919003627	ATP binding site [chemical binding]; other site
1074919003628	Q-loop/lid; other site
1074919003629	ABC transporter signature motif; other site
1074919003630	Walker B; other site
1074919003631	D-loop; other site
1074919003632	H-loop/switch region; other site
1074919003633	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1074919003634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919003635	dimer interface [polypeptide binding]; other site
1074919003636	conserved gate region; other site
1074919003637	putative PBP binding loops; other site
1074919003638	ABC-ATPase subunit interface; other site
1074919003639	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919003640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919003641	dimer interface [polypeptide binding]; other site
1074919003642	conserved gate region; other site
1074919003643	putative PBP binding loops; other site
1074919003644	ABC-ATPase subunit interface; other site
1074919003645	oligoendopeptidase F; Region: pepF; TIGR00181
1074919003646	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1074919003647	active site
1074919003648	Zn binding site [ion binding]; other site
1074919003649	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1074919003650	PhoU domain; Region: PhoU; pfam01895
1074919003651	PhoU domain; Region: PhoU; pfam01895
1074919003652	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
1074919003653	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1074919003654	Walker A/P-loop; other site
1074919003655	ATP binding site [chemical binding]; other site
1074919003656	Q-loop/lid; other site
1074919003657	ABC transporter signature motif; other site
1074919003658	Walker B; other site
1074919003659	D-loop; other site
1074919003660	H-loop/switch region; other site
1074919003661	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1074919003662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919003663	dimer interface [polypeptide binding]; other site
1074919003664	conserved gate region; other site
1074919003665	putative PBP binding loops; other site
1074919003666	ABC-ATPase subunit interface; other site
1074919003667	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1074919003668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919003669	dimer interface [polypeptide binding]; other site
1074919003670	conserved gate region; other site
1074919003671	ABC-ATPase subunit interface; other site
1074919003672	phosphate binding protein; Region: ptsS_2; TIGR02136
1074919003673	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1074919003674	S1 domain; Region: S1_2; pfam13509
1074919003675	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1074919003676	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919003677	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919003678	ABC transporter; Region: ABC_tran_2; pfam12848
1074919003679	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919003680	aspartate kinase; Reviewed; Region: PRK06635
1074919003681	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1074919003682	putative nucleotide binding site [chemical binding]; other site
1074919003683	putative catalytic residues [active]
1074919003684	putative Mg ion binding site [ion binding]; other site
1074919003685	putative aspartate binding site [chemical binding]; other site
1074919003686	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
1074919003687	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
1074919003688	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1074919003689	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1074919003690	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1074919003691	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1074919003692	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1074919003693	dimer interface [polypeptide binding]; other site
1074919003694	active site
1074919003695	catalytic residue [active]
1074919003696	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1074919003697	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1074919003698	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1074919003699	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1074919003700	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1074919003701	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1074919003702	active site
1074919003703	trimer interface [polypeptide binding]; other site
1074919003704	substrate binding site [chemical binding]; other site
1074919003705	CoA binding site [chemical binding]; other site
1074919003706	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074919003707	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1074919003708	metal binding site [ion binding]; metal-binding site
1074919003709	dimer interface [polypeptide binding]; other site
1074919003710	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1074919003711	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1074919003712	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919003713	catalytic residue [active]
1074919003714	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1074919003715	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1074919003716	active site
1074919003717	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919003718	substrate binding site [chemical binding]; other site
1074919003719	catalytic residues [active]
1074919003720	dimer interface [polypeptide binding]; other site
1074919003721	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
1074919003722	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1074919003723	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
1074919003724	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1074919003725	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1074919003726	metal ion-dependent adhesion site (MIDAS); other site
1074919003727	MoxR-like ATPases [General function prediction only]; Region: COG0714
1074919003728	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919003729	Walker A motif; other site
1074919003730	ATP binding site [chemical binding]; other site
1074919003731	Walker B motif; other site
1074919003732	arginine finger; other site
1074919003733	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1074919003734	active site
1074919003735	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1074919003736	active site
1074919003737	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1074919003738	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1074919003739	E3 interaction surface; other site
1074919003740	lipoyl attachment site [posttranslational modification]; other site
1074919003741	e3 binding domain; Region: E3_binding; pfam02817
1074919003742	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1074919003743	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1074919003744	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1074919003745	TPP-binding site [chemical binding]; other site
1074919003746	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
1074919003747	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1074919003748	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919003749	HAMP domain; Region: HAMP; pfam00672
1074919003750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919003751	dimer interface [polypeptide binding]; other site
1074919003752	phosphorylation site [posttranslational modification]
1074919003753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919003754	ATP binding site [chemical binding]; other site
1074919003755	Mg2+ binding site [ion binding]; other site
1074919003756	G-X-G motif; other site
1074919003757	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919003758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919003759	active site
1074919003760	phosphorylation site [posttranslational modification]
1074919003761	intermolecular recognition site; other site
1074919003762	dimerization interface [polypeptide binding]; other site
1074919003763	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919003764	DNA binding site [nucleotide binding]
1074919003765	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1074919003766	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1074919003767	active site
1074919003768	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1074919003769	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1074919003770	active site
1074919003771	homodimer interface [polypeptide binding]; other site
1074919003772	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919003773	Coenzyme A binding pocket [chemical binding]; other site
1074919003774	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1074919003775	C-terminal peptidase (prc); Region: prc; TIGR00225
1074919003776	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1074919003777	protein binding site [polypeptide binding]; other site
1074919003778	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1074919003779	Catalytic dyad [active]
1074919003780	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1074919003781	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1074919003782	HPr interaction site; other site
1074919003783	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074919003784	active site
1074919003785	phosphorylation site [posttranslational modification]
1074919003786	methionine sulfoxide reductase A; Provisional; Region: PRK13014
1074919003787	EDD domain protein, DegV family; Region: DegV; TIGR00762
1074919003788	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1074919003789	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1074919003790	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1074919003791	folate binding site [chemical binding]; other site
1074919003792	NADP+ binding site [chemical binding]; other site
1074919003793	thymidylate synthase; Region: thym_sym; TIGR03284
1074919003794	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1074919003795	dimerization interface [polypeptide binding]; other site
1074919003796	active site
1074919003797	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1074919003798	Virulence factor; Region: Virulence_fact; pfam13769
1074919003799	HEAT repeats; Region: HEAT_2; pfam13646
1074919003800	HEAT repeat; Region: HEAT; pfam02985
1074919003801	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1074919003802	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919003803	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919003804	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919003805	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919003806	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
1074919003807	GA module; Region: GA; smart00844
1074919003808	GA module; Region: GA; smart00844
1074919003809	GA module; Region: GA; smart00844
1074919003810	GA module; Region: GA; smart00844
1074919003811	GA module; Region: GA; smart00844
1074919003812	GA module; Region: GA; smart00844
1074919003813	GA module; Region: GA; smart00844
1074919003814	GA module; Region: GA; smart00844
1074919003815	GA module; Region: GA; smart00844
1074919003816	GA module; Region: GA; smart00844
1074919003817	GA module; Region: GA; smart00844
1074919003818	GA module; Region: GA; smart00844
1074919003819	GA module; Region: GA; smart00844
1074919003820	GA module; Region: GA; smart00844
1074919003821	GA module; Region: GA; smart00844
1074919003822	GA module; Region: GA; smart00844
1074919003823	GA module; Region: GA; smart00844
1074919003824	GA module; Region: GA; smart00844
1074919003825	GA module; Region: GA; smart00844
1074919003826	GA module; Region: GA; smart00844
1074919003827	GA module; Region: GA; smart00844
1074919003828	GA module; Region: GA; smart00844
1074919003829	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
1074919003830	GA module; Region: GA; smart00844
1074919003831	GA module; Region: GA; smart00844
1074919003832	GA module; Region: GA; pfam01468
1074919003833	GA module; Region: GA; smart00844
1074919003834	GA module; Region: GA; smart00844
1074919003835	GA module; Region: GA; smart00844
1074919003836	GA module; Region: GA; smart00844
1074919003837	GA module; Region: GA; pfam01468
1074919003838	GA module; Region: GA; smart00844
1074919003839	GA module; Region: GA; smart00844
1074919003840	GA module; Region: GA; smart00844
1074919003841	GA module; Region: GA; smart00844
1074919003842	GA module; Region: GA; smart00844
1074919003843	GA module; Region: GA; smart00844
1074919003844	chromosome segregation protein; Provisional; Region: PRK02224
1074919003845	GA module; Region: GA; smart00844
1074919003846	GA module; Region: GA; smart00844
1074919003847	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1074919003848	GA module; Region: GA; pfam01468
1074919003849	GA module; Region: GA; smart00844
1074919003850	GA module; Region: GA; smart00844
1074919003851	GA module; Region: GA; smart00844
1074919003852	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1074919003853	Amino acid permease; Region: AA_permease_2; pfam13520
1074919003854	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1074919003855	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1074919003856	tetramer interface [polypeptide binding]; other site
1074919003857	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919003858	catalytic residue [active]
1074919003859	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1074919003860	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1074919003861	hexamer interface [polypeptide binding]; other site
1074919003862	ligand binding site [chemical binding]; other site
1074919003863	putative active site [active]
1074919003864	NAD(P) binding site [chemical binding]; other site
1074919003865	5'-3' exonuclease; Region: 53EXOc; smart00475
1074919003866	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1074919003867	active site
1074919003868	metal binding site 1 [ion binding]; metal-binding site
1074919003869	putative 5' ssDNA interaction site; other site
1074919003870	metal binding site 3; metal-binding site
1074919003871	metal binding site 2 [ion binding]; metal-binding site
1074919003872	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1074919003873	putative DNA binding site [nucleotide binding]; other site
1074919003874	putative metal binding site [ion binding]; other site
1074919003875	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1074919003876	Dynamin family; Region: Dynamin_N; pfam00350
1074919003877	G1 box; other site
1074919003878	GTP/Mg2+ binding site [chemical binding]; other site
1074919003879	G2 box; other site
1074919003880	Switch I region; other site
1074919003881	G3 box; other site
1074919003882	Switch II region; other site
1074919003883	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1074919003884	G4 box; other site
1074919003885	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1074919003886	Dynamin family; Region: Dynamin_N; pfam00350
1074919003887	G1 box; other site
1074919003888	GTP/Mg2+ binding site [chemical binding]; other site
1074919003889	G2 box; other site
1074919003890	Switch I region; other site
1074919003891	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1074919003892	G3 box; other site
1074919003893	Switch II region; other site
1074919003894	GTP/Mg2+ binding site [chemical binding]; other site
1074919003895	G4 box; other site
1074919003896	G5 box; other site
1074919003897	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1074919003898	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1074919003899	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1074919003900	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1074919003901	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1074919003902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1074919003903	hypothetical protein; Provisional; Region: PRK13660
1074919003904	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1074919003905	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1074919003906	Transglycosylase; Region: Transgly; pfam00912
1074919003907	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1074919003908	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1074919003909	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1074919003910	minor groove reading motif; other site
1074919003911	helix-hairpin-helix signature motif; other site
1074919003912	substrate binding pocket [chemical binding]; other site
1074919003913	active site
1074919003914	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1074919003915	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1074919003916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
1074919003917	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1074919003918	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1074919003919	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1074919003920	putative dimer interface [polypeptide binding]; other site
1074919003921	putative anticodon binding site; other site
1074919003922	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1074919003923	homodimer interface [polypeptide binding]; other site
1074919003924	motif 1; other site
1074919003925	motif 2; other site
1074919003926	active site
1074919003927	motif 3; other site
1074919003928	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1074919003929	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1074919003930	active site
1074919003931	catalytic site [active]
1074919003932	substrate binding site [chemical binding]; other site
1074919003933	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1074919003934	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1074919003935	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1074919003936	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1074919003937	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1074919003938	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1074919003939	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1074919003940	active site
1074919003941	NTP binding site [chemical binding]; other site
1074919003942	metal binding triad [ion binding]; metal-binding site
1074919003943	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1074919003944	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1074919003945	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1074919003946	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1074919003947	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1074919003948	Protein of unknown function (DUF1405); Region: DUF1405; cl01798
1074919003949	Uncharacterized conserved protein [Function unknown]; Region: COG5582
1074919003950	UPF0302 domain; Region: UPF0302; pfam08864
1074919003951	A short protein domain of unknown function; Region: IDEAL; smart00914
1074919003952	TPR repeat; Region: TPR_11; pfam13414
1074919003953	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919003954	binding surface
1074919003955	TPR motif; other site
1074919003956	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919003957	TPR motif; other site
1074919003958	binding surface
1074919003959	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1074919003960	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1074919003961	hinge; other site
1074919003962	active site
1074919003963	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1074919003964	active site
1074919003965	NAD binding site [chemical binding]; other site
1074919003966	metal binding site [ion binding]; metal-binding site
1074919003967	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1074919003968	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1074919003969	Tetramer interface [polypeptide binding]; other site
1074919003970	active site
1074919003971	FMN-binding site [chemical binding]; other site
1074919003972	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1074919003973	active site
1074919003974	multimer interface [polypeptide binding]; other site
1074919003975	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1074919003976	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1074919003977	substrate binding pocket [chemical binding]; other site
1074919003978	chain length determination region; other site
1074919003979	substrate-Mg2+ binding site; other site
1074919003980	catalytic residues [active]
1074919003981	aspartate-rich region 1; other site
1074919003982	active site lid residues [active]
1074919003983	aspartate-rich region 2; other site
1074919003984	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1074919003985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919003986	S-adenosylmethionine binding site [chemical binding]; other site
1074919003987	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1074919003988	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1074919003989	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1074919003990	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1074919003991	GTP-binding protein Der; Reviewed; Region: PRK00093
1074919003992	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1074919003993	G1 box; other site
1074919003994	GTP/Mg2+ binding site [chemical binding]; other site
1074919003995	Switch I region; other site
1074919003996	G2 box; other site
1074919003997	Switch II region; other site
1074919003998	G3 box; other site
1074919003999	G4 box; other site
1074919004000	G5 box; other site
1074919004001	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1074919004002	G1 box; other site
1074919004003	GTP/Mg2+ binding site [chemical binding]; other site
1074919004004	Switch I region; other site
1074919004005	G2 box; other site
1074919004006	G3 box; other site
1074919004007	Switch II region; other site
1074919004008	G4 box; other site
1074919004009	G5 box; other site
1074919004010	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1074919004011	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1074919004012	RNA binding site [nucleotide binding]; other site
1074919004013	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1074919004014	RNA binding site [nucleotide binding]; other site
1074919004015	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1074919004016	RNA binding site [nucleotide binding]; other site
1074919004017	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1074919004018	RNA binding site [nucleotide binding]; other site
1074919004019	cytidylate kinase; Provisional; Region: cmk; PRK00023
1074919004020	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1074919004021	CMP-binding site; other site
1074919004022	The sites determining sugar specificity; other site
1074919004023	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1074919004024	active site
1074919004025	homotetramer interface [polypeptide binding]; other site
1074919004026	homodimer interface [polypeptide binding]; other site
1074919004027	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1074919004028	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1074919004029	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919004030	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919004031	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1074919004032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919004033	ATP binding site [chemical binding]; other site
1074919004034	putative Mg++ binding site [ion binding]; other site
1074919004035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919004036	nucleotide binding region [chemical binding]; other site
1074919004037	ATP-binding site [chemical binding]; other site
1074919004038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1074919004039	Predicted membrane protein [Function unknown]; Region: COG3601
1074919004040	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1074919004041	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1074919004042	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1074919004043	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1074919004044	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1074919004045	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074919004046	dimerization interface [polypeptide binding]; other site
1074919004047	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1074919004048	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919004049	dimer interface [polypeptide binding]; other site
1074919004050	phosphorylation site [posttranslational modification]
1074919004051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919004052	ATP binding site [chemical binding]; other site
1074919004053	Mg2+ binding site [ion binding]; other site
1074919004054	G-X-G motif; other site
1074919004055	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919004056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919004057	active site
1074919004058	phosphorylation site [posttranslational modification]
1074919004059	intermolecular recognition site; other site
1074919004060	dimerization interface [polypeptide binding]; other site
1074919004061	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919004062	DNA binding site [nucleotide binding]
1074919004063	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919004064	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1074919004065	pseudouridine synthase; Region: TIGR00093
1074919004066	active site
1074919004067	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1074919004068	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1074919004069	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
1074919004070	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1074919004071	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1074919004072	active site
1074919004073	Int/Topo IB signature motif; other site
1074919004074	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1074919004075	dimer interface [polypeptide binding]; other site
1074919004076	ADP-ribose binding site [chemical binding]; other site
1074919004077	active site
1074919004078	nudix motif; other site
1074919004079	metal binding site [ion binding]; metal-binding site
1074919004080	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919004081	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074919004082	active site
1074919004083	catalytic tetrad [active]
1074919004084	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1074919004085	classical (c) SDRs; Region: SDR_c; cd05233
1074919004086	NAD(P) binding site [chemical binding]; other site
1074919004087	active site
1074919004088	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1074919004089	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1074919004090	ribonuclease Z; Region: RNase_Z; TIGR02651
1074919004091	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1074919004092	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1074919004093	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1074919004094	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1074919004095	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1074919004096	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1074919004097	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1074919004098	Ca binding site [ion binding]; other site
1074919004099	active site
1074919004100	catalytic site [active]
1074919004101	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1074919004102	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1074919004103	DNA binding site [nucleotide binding]
1074919004104	domain linker motif; other site
1074919004105	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1074919004106	putative ligand binding site [chemical binding]; other site
1074919004107	putative dimerization interface [polypeptide binding]; other site
1074919004108	H+ Antiporter protein; Region: 2A0121; TIGR00900
1074919004109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919004110	putative substrate translocation pore; other site
1074919004111	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1074919004112	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1074919004113	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1074919004114	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1074919004115	peptidase T-like protein; Region: PepT-like; TIGR01883
1074919004116	metal binding site [ion binding]; metal-binding site
1074919004117	putative dimer interface [polypeptide binding]; other site
1074919004118	Predicted membrane protein [Function unknown]; Region: COG4129
1074919004119	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1074919004120	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1074919004121	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1074919004122	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1074919004123	E3 interaction surface; other site
1074919004124	lipoyl attachment site [posttranslational modification]; other site
1074919004125	e3 binding domain; Region: E3_binding; pfam02817
1074919004126	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1074919004127	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1074919004128	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1074919004129	alpha subunit interface [polypeptide binding]; other site
1074919004130	TPP binding site [chemical binding]; other site
1074919004131	heterodimer interface [polypeptide binding]; other site
1074919004132	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1074919004133	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1074919004134	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1074919004135	tetramer interface [polypeptide binding]; other site
1074919004136	TPP-binding site [chemical binding]; other site
1074919004137	heterodimer interface [polypeptide binding]; other site
1074919004138	phosphorylation loop region [posttranslational modification]
1074919004139	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1074919004140	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1074919004141	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919004142	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074919004143	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1074919004144	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1074919004145	Walker A/P-loop; other site
1074919004146	ATP binding site [chemical binding]; other site
1074919004147	Q-loop/lid; other site
1074919004148	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1074919004149	ABC transporter signature motif; other site
1074919004150	Walker B; other site
1074919004151	D-loop; other site
1074919004152	H-loop/switch region; other site
1074919004153	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1074919004154	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1074919004155	substrate binding pocket [chemical binding]; other site
1074919004156	chain length determination region; other site
1074919004157	substrate-Mg2+ binding site; other site
1074919004158	catalytic residues [active]
1074919004159	aspartate-rich region 1; other site
1074919004160	active site lid residues [active]
1074919004161	aspartate-rich region 2; other site
1074919004162	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1074919004163	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1074919004164	generic binding surface II; other site
1074919004165	generic binding surface I; other site
1074919004166	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1074919004167	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919004168	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1074919004169	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1074919004170	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1074919004171	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1074919004172	carboxyltransferase (CT) interaction site; other site
1074919004173	biotinylation site [posttranslational modification]; other site
1074919004174	elongation factor P; Validated; Region: PRK00529
1074919004175	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1074919004176	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1074919004177	RNA binding site [nucleotide binding]; other site
1074919004178	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1074919004179	RNA binding site [nucleotide binding]; other site
1074919004180	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1074919004181	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1074919004182	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1074919004183	active site
1074919004184	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1074919004185	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1074919004186	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1074919004187	tetramer interface [polypeptide binding]; other site
1074919004188	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919004189	catalytic residue [active]
1074919004190	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1074919004191	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1074919004192	tetramer interface [polypeptide binding]; other site
1074919004193	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919004194	catalytic residue [active]
1074919004195	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1074919004196	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1074919004197	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1074919004198	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1074919004199	ADP binding site [chemical binding]; other site
1074919004200	magnesium binding site [ion binding]; other site
1074919004201	putative shikimate binding site; other site
1074919004202	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1074919004203	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1074919004204	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1074919004205	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1074919004206	Type II/IV secretion system protein; Region: T2SE; pfam00437
1074919004207	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1074919004208	Walker A motif; other site
1074919004209	ATP binding site [chemical binding]; other site
1074919004210	Walker B motif; other site
1074919004211	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1074919004212	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1074919004213	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1074919004214	Rhomboid family; Region: Rhomboid; pfam01694
1074919004215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919004216	binding surface
1074919004217	TPR motif; other site
1074919004218	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1074919004219	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1074919004220	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1074919004221	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1074919004222	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1074919004223	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1074919004224	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1074919004225	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1074919004226	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1074919004227	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1074919004228	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919004229	ABC-ATPase subunit  interface; other site
1074919004230	dimer interface [polypeptide binding]; other site
1074919004231	putative PBP binding regions; other site
1074919004232	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1074919004233	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1074919004234	endonuclease IV; Provisional; Region: PRK01060
1074919004235	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1074919004236	AP (apurinic/apyrimidinic) site pocket; other site
1074919004237	DNA interaction; other site
1074919004238	Metal-binding active site; metal-binding site
1074919004239	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1074919004240	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1074919004241	ATP binding site [chemical binding]; other site
1074919004242	putative Mg++ binding site [ion binding]; other site
1074919004243	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919004244	nucleotide binding region [chemical binding]; other site
1074919004245	ATP-binding site [chemical binding]; other site
1074919004246	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1074919004247	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1074919004248	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1074919004249	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1074919004250	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1074919004251	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1074919004252	Family of unknown function (DUF633); Region: DUF633; pfam04816
1074919004253	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1074919004254	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1074919004255	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1074919004256	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074919004257	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1074919004258	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074919004259	DNA binding residues [nucleotide binding]
1074919004260	DNA primase, catalytic core; Region: dnaG; TIGR01391
1074919004261	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1074919004262	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1074919004263	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1074919004264	active site
1074919004265	metal binding site [ion binding]; metal-binding site
1074919004266	interdomain interaction site; other site
1074919004267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
1074919004268	FOG: CBS domain [General function prediction only]; Region: COG0517
1074919004269	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1074919004270	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1074919004271	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1074919004272	motif 1; other site
1074919004273	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1074919004274	active site
1074919004275	motif 2; other site
1074919004276	motif 3; other site
1074919004277	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1074919004278	anticodon binding site; other site
1074919004279	DNA repair protein RecO; Region: reco; TIGR00613
1074919004280	Recombination protein O N terminal; Region: RecO_N; pfam11967
1074919004281	Recombination protein O C terminal; Region: RecO_C; pfam02565
1074919004282	GTPase Era; Reviewed; Region: era; PRK00089
1074919004283	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1074919004284	G1 box; other site
1074919004285	GTP/Mg2+ binding site [chemical binding]; other site
1074919004286	Switch I region; other site
1074919004287	G2 box; other site
1074919004288	Switch II region; other site
1074919004289	G3 box; other site
1074919004290	G4 box; other site
1074919004291	G5 box; other site
1074919004292	KH domain; Region: KH_2; pfam07650
1074919004293	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1074919004294	PhoH-like protein; Region: PhoH; pfam02562
1074919004295	hypothetical protein; Provisional; Region: PRK13665
1074919004296	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1074919004297	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1074919004298	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1074919004299	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919004300	FeS/SAM binding site; other site
1074919004301	TRAM domain; Region: TRAM; cl01282
1074919004302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1074919004303	RNA methyltransferase, RsmE family; Region: TIGR00046
1074919004304	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1074919004305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004306	S-adenosylmethionine binding site [chemical binding]; other site
1074919004307	chaperone protein DnaJ; Provisional; Region: PRK14280
1074919004308	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1074919004309	HSP70 interaction site [polypeptide binding]; other site
1074919004310	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1074919004311	substrate binding site [polypeptide binding]; other site
1074919004312	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1074919004313	Zn binding sites [ion binding]; other site
1074919004314	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1074919004315	dimer interface [polypeptide binding]; other site
1074919004316	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1074919004317	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1074919004318	nucleotide binding site [chemical binding]; other site
1074919004319	NEF interaction site [polypeptide binding]; other site
1074919004320	SBD interface [polypeptide binding]; other site
1074919004321	heat shock protein GrpE; Provisional; Region: PRK14140
1074919004322	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1074919004323	dimer interface [polypeptide binding]; other site
1074919004324	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1074919004325	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1074919004326	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
1074919004327	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
1074919004328	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1074919004329	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919004330	FeS/SAM binding site; other site
1074919004331	HemN C-terminal domain; Region: HemN_C; pfam06969
1074919004332	GTP-binding protein LepA; Provisional; Region: PRK05433
1074919004333	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1074919004334	G1 box; other site
1074919004335	putative GEF interaction site [polypeptide binding]; other site
1074919004336	GTP/Mg2+ binding site [chemical binding]; other site
1074919004337	Switch I region; other site
1074919004338	G2 box; other site
1074919004339	G3 box; other site
1074919004340	Switch II region; other site
1074919004341	G4 box; other site
1074919004342	G5 box; other site
1074919004343	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1074919004344	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1074919004345	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1074919004346	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1074919004347	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1074919004348	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1074919004349	Competence protein; Region: Competence; pfam03772
1074919004350	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1074919004351	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1074919004352	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1074919004353	catalytic motif [active]
1074919004354	Zn binding site [ion binding]; other site
1074919004355	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1074919004356	Helix-hairpin-helix motif; Region: HHH; pfam00633
1074919004357	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1074919004358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004359	S-adenosylmethionine binding site [chemical binding]; other site
1074919004360	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919004361	Zn2+ binding site [ion binding]; other site
1074919004362	Mg2+ binding site [ion binding]; other site
1074919004363	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1074919004364	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
1074919004365	active site
1074919004366	(T/H)XGH motif; other site
1074919004367	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1074919004368	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1074919004369	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1074919004370	shikimate binding site; other site
1074919004371	NAD(P) binding site [chemical binding]; other site
1074919004372	GTPase YqeH; Provisional; Region: PRK13796
1074919004373	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1074919004374	GTP/Mg2+ binding site [chemical binding]; other site
1074919004375	G4 box; other site
1074919004376	G5 box; other site
1074919004377	G1 box; other site
1074919004378	Switch I region; other site
1074919004379	G2 box; other site
1074919004380	G3 box; other site
1074919004381	Switch II region; other site
1074919004382	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1074919004383	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919004384	active site
1074919004385	motif I; other site
1074919004386	motif II; other site
1074919004387	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1074919004388	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1074919004389	Fic family protein [Function unknown]; Region: COG3177
1074919004390	Fic/DOC family; Region: Fic; pfam02661
1074919004391	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1074919004392	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1074919004393	putative active site [active]
1074919004394	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919004395	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1074919004396	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074919004397	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1074919004398	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1074919004399	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1074919004400	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1074919004401	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1074919004402	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1074919004403	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1074919004404	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1074919004405	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1074919004406	Sugar specificity; other site
1074919004407	Pyrimidine base specificity; other site
1074919004408	ATP-binding site [chemical binding]; other site
1074919004409	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1074919004410	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1074919004411	Peptidase family U32; Region: Peptidase_U32; pfam01136
1074919004412	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1074919004413	Peptidase family U32; Region: Peptidase_U32; pfam01136
1074919004414	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1074919004415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004416	S-adenosylmethionine binding site [chemical binding]; other site
1074919004417	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1074919004418	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1074919004419	motif 1; other site
1074919004420	active site
1074919004421	motif 2; other site
1074919004422	motif 3; other site
1074919004423	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1074919004424	DHHA1 domain; Region: DHHA1; pfam02272
1074919004425	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1074919004426	AAA domain; Region: AAA_30; pfam13604
1074919004427	Family description; Region: UvrD_C_2; pfam13538
1074919004428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919004429	binding surface
1074919004430	TPR motif; other site
1074919004431	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1074919004432	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919004433	binding surface
1074919004434	TPR motif; other site
1074919004435	TPR repeat; Region: TPR_11; pfam13414
1074919004436	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1074919004437	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1074919004438	Ligand Binding Site [chemical binding]; other site
1074919004439	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1074919004440	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1074919004441	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919004442	catalytic residue [active]
1074919004443	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1074919004444	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1074919004445	recombination factor protein RarA; Reviewed; Region: PRK13342
1074919004446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919004447	Walker A motif; other site
1074919004448	ATP binding site [chemical binding]; other site
1074919004449	Walker B motif; other site
1074919004450	arginine finger; other site
1074919004451	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1074919004452	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1074919004453	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1074919004454	putative ATP binding site [chemical binding]; other site
1074919004455	putative substrate interface [chemical binding]; other site
1074919004456	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1074919004457	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1074919004458	dimer interface [polypeptide binding]; other site
1074919004459	anticodon binding site; other site
1074919004460	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1074919004461	homodimer interface [polypeptide binding]; other site
1074919004462	motif 1; other site
1074919004463	active site
1074919004464	motif 2; other site
1074919004465	GAD domain; Region: GAD; pfam02938
1074919004466	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1074919004467	motif 3; other site
1074919004468	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1074919004469	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1074919004470	dimer interface [polypeptide binding]; other site
1074919004471	motif 1; other site
1074919004472	active site
1074919004473	motif 2; other site
1074919004474	motif 3; other site
1074919004475	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1074919004476	anticodon binding site; other site
1074919004477	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1074919004478	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1074919004479	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1074919004480	active site
1074919004481	metal binding site [ion binding]; metal-binding site
1074919004482	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1074919004483	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919004484	Zn2+ binding site [ion binding]; other site
1074919004485	Mg2+ binding site [ion binding]; other site
1074919004486	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1074919004487	synthetase active site [active]
1074919004488	NTP binding site [chemical binding]; other site
1074919004489	metal binding site [ion binding]; metal-binding site
1074919004490	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1074919004491	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1074919004492	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919004493	active site
1074919004494	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1074919004495	DHH family; Region: DHH; pfam01368
1074919004496	DHHA1 domain; Region: DHHA1; pfam02272
1074919004497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1074919004498	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1074919004499	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1074919004500	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1074919004501	Protein export membrane protein; Region: SecD_SecF; pfam02355
1074919004502	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1074919004503	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1074919004504	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1074919004505	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1074919004506	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1074919004507	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919004508	Walker A motif; other site
1074919004509	ATP binding site [chemical binding]; other site
1074919004510	Walker B motif; other site
1074919004511	arginine finger; other site
1074919004512	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1074919004513	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1074919004514	RuvA N terminal domain; Region: RuvA_N; pfam01330
1074919004515	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1074919004516	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1074919004517	GTP1/OBG; Region: GTP1_OBG; pfam01018
1074919004518	Obg GTPase; Region: Obg; cd01898
1074919004519	G1 box; other site
1074919004520	GTP/Mg2+ binding site [chemical binding]; other site
1074919004521	Switch I region; other site
1074919004522	G2 box; other site
1074919004523	G3 box; other site
1074919004524	Switch II region; other site
1074919004525	G4 box; other site
1074919004526	G5 box; other site
1074919004527	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1074919004528	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1074919004529	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
1074919004530	rod shape-determining protein MreC; Region: MreC; pfam04085
1074919004531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004532	S-adenosylmethionine binding site [chemical binding]; other site
1074919004533	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1074919004534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004535	S-adenosylmethionine binding site [chemical binding]; other site
1074919004536	aminoglycoside resistance protein; Provisional; Region: PRK13746
1074919004537	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1074919004538	active site
1074919004539	NTP binding site [chemical binding]; other site
1074919004540	metal binding triad [ion binding]; metal-binding site
1074919004541	antibiotic binding site [chemical binding]; other site
1074919004542	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1074919004543	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919004544	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919004545	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919004546	active site
1074919004547	DNA binding site [nucleotide binding]
1074919004548	Int/Topo IB signature motif; other site
1074919004549	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919004550	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1074919004551	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1074919004552	Int/Topo IB signature motif; other site
1074919004553	hypothetical protein; Reviewed; Region: PRK00024
1074919004554	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1074919004555	MPN+ (JAMM) motif; other site
1074919004556	Zinc-binding site [ion binding]; other site
1074919004557	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1074919004558	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1074919004559	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1074919004560	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1074919004561	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919004562	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919004563	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1074919004564	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1074919004565	active site
1074919004566	HIGH motif; other site
1074919004567	nucleotide binding site [chemical binding]; other site
1074919004568	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1074919004569	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1074919004570	active site
1074919004571	KMSKS motif; other site
1074919004572	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1074919004573	tRNA binding surface [nucleotide binding]; other site
1074919004574	anticodon binding site; other site
1074919004575	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1074919004576	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1074919004577	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1074919004578	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1074919004579	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919004580	inhibitor-cofactor binding pocket; inhibition site
1074919004581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919004582	catalytic residue [active]
1074919004583	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1074919004584	dimer interface [polypeptide binding]; other site
1074919004585	active site
1074919004586	Schiff base residues; other site
1074919004587	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1074919004588	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1074919004589	active site
1074919004590	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1074919004591	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1074919004592	domain interfaces; other site
1074919004593	active site
1074919004594	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
1074919004595	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1074919004596	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1074919004597	tRNA; other site
1074919004598	putative tRNA binding site [nucleotide binding]; other site
1074919004599	putative NADP binding site [chemical binding]; other site
1074919004600	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1074919004601	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1074919004602	G1 box; other site
1074919004603	GTP/Mg2+ binding site [chemical binding]; other site
1074919004604	Switch I region; other site
1074919004605	G2 box; other site
1074919004606	G3 box; other site
1074919004607	Switch II region; other site
1074919004608	G4 box; other site
1074919004609	G5 box; other site
1074919004610	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1074919004611	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1074919004612	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919004613	Walker A motif; other site
1074919004614	ATP binding site [chemical binding]; other site
1074919004615	Walker B motif; other site
1074919004616	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1074919004617	trigger factor; Provisional; Region: tig; PRK01490
1074919004618	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1074919004619	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1074919004620	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
1074919004621	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1074919004622	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1074919004623	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1074919004624	lysine transporter; Provisional; Region: PRK10836
1074919004625	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1074919004626	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1074919004627	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1074919004628	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1074919004629	active site
1074919004630	dimer interface [polypeptide binding]; other site
1074919004631	motif 1; other site
1074919004632	motif 2; other site
1074919004633	motif 3; other site
1074919004634	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1074919004635	anticodon binding site; other site
1074919004636	primosomal protein DnaI; Reviewed; Region: PRK08939
1074919004637	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1074919004638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919004639	Walker A motif; other site
1074919004640	ATP binding site [chemical binding]; other site
1074919004641	Walker B motif; other site
1074919004642	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1074919004643	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1074919004644	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1074919004645	ATP cone domain; Region: ATP-cone; pfam03477
1074919004646	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
1074919004647	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1074919004648	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1074919004649	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1074919004650	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1074919004651	CoA-binding site [chemical binding]; other site
1074919004652	ATP-binding [chemical binding]; other site
1074919004653	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1074919004654	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1074919004655	DNA binding site [nucleotide binding]
1074919004656	catalytic residue [active]
1074919004657	H2TH interface [polypeptide binding]; other site
1074919004658	putative catalytic residues [active]
1074919004659	turnover-facilitating residue; other site
1074919004660	intercalation triad [nucleotide binding]; other site
1074919004661	8OG recognition residue [nucleotide binding]; other site
1074919004662	putative reading head residues; other site
1074919004663	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1074919004664	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1074919004665	DNA polymerase I; Provisional; Region: PRK05755
1074919004666	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1074919004667	active site
1074919004668	metal binding site 1 [ion binding]; metal-binding site
1074919004669	putative 5' ssDNA interaction site; other site
1074919004670	metal binding site 3; metal-binding site
1074919004671	metal binding site 2 [ion binding]; metal-binding site
1074919004672	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1074919004673	putative DNA binding site [nucleotide binding]; other site
1074919004674	putative metal binding site [ion binding]; other site
1074919004675	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1074919004676	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1074919004677	active site
1074919004678	DNA binding site [nucleotide binding]
1074919004679	catalytic site [active]
1074919004680	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1074919004681	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919004682	dimer interface [polypeptide binding]; other site
1074919004683	phosphorylation site [posttranslational modification]
1074919004684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919004685	ATP binding site [chemical binding]; other site
1074919004686	Mg2+ binding site [ion binding]; other site
1074919004687	G-X-G motif; other site
1074919004688	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919004689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919004690	active site
1074919004691	phosphorylation site [posttranslational modification]
1074919004692	intermolecular recognition site; other site
1074919004693	dimerization interface [polypeptide binding]; other site
1074919004694	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919004695	DNA binding site [nucleotide binding]
1074919004696	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1074919004697	isocitrate dehydrogenase; Validated; Region: PRK07362
1074919004698	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1074919004699	dimer interface [polypeptide binding]; other site
1074919004700	Citrate synthase; Region: Citrate_synt; pfam00285
1074919004701	active site
1074919004702	citrylCoA binding site [chemical binding]; other site
1074919004703	oxalacetate/citrate binding site [chemical binding]; other site
1074919004704	coenzyme A binding site [chemical binding]; other site
1074919004705	catalytic triad [active]
1074919004706	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1074919004707	pyruvate kinase; Provisional; Region: PRK06354
1074919004708	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1074919004709	domain interfaces; other site
1074919004710	active site
1074919004711	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1074919004712	6-phosphofructokinase; Provisional; Region: PRK03202
1074919004713	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1074919004714	active site
1074919004715	ADP/pyrophosphate binding site [chemical binding]; other site
1074919004716	dimerization interface [polypeptide binding]; other site
1074919004717	allosteric effector site; other site
1074919004718	fructose-1,6-bisphosphate binding site; other site
1074919004719	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1074919004720	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1074919004721	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1074919004722	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1074919004723	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1074919004724	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1074919004725	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1074919004726	putative NAD(P) binding site [chemical binding]; other site
1074919004727	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1074919004728	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1074919004729	active site
1074919004730	PHP Thumb interface [polypeptide binding]; other site
1074919004731	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1074919004732	generic binding surface I; other site
1074919004733	generic binding surface II; other site
1074919004734	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1074919004735	DHH family; Region: DHH; pfam01368
1074919004736	DHHA1 domain; Region: DHHA1; pfam02272
1074919004737	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1074919004738	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1074919004739	DNA-binding site [nucleotide binding]; DNA binding site
1074919004740	DRTGG domain; Region: DRTGG; pfam07085
1074919004741	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1074919004742	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1074919004743	active site 2 [active]
1074919004744	active site 1 [active]
1074919004745	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1074919004746	metal-dependent hydrolase; Provisional; Region: PRK00685
1074919004747	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1074919004748	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1074919004749	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1074919004750	active site
1074919004751	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1074919004752	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1074919004753	hexamer interface [polypeptide binding]; other site
1074919004754	ligand binding site [chemical binding]; other site
1074919004755	putative active site [active]
1074919004756	NAD(P) binding site [chemical binding]; other site
1074919004757	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1074919004758	Ligand Binding Site [chemical binding]; other site
1074919004759	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1074919004760	propionate/acetate kinase; Provisional; Region: PRK12379
1074919004761	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1074919004762	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004763	S-adenosylmethionine binding site [chemical binding]; other site
1074919004764	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1074919004765	dimer interface [polypeptide binding]; other site
1074919004766	catalytic triad [active]
1074919004767	peroxidatic and resolving cysteines [active]
1074919004768	hypothetical protein; Provisional; Region: PRK10621
1074919004769	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1074919004770	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1074919004771	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1074919004772	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1074919004773	Ligand Binding Site [chemical binding]; other site
1074919004774	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1074919004775	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1074919004776	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919004777	catalytic residue [active]
1074919004778	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
1074919004779	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1074919004780	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1074919004781	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919004782	RNA binding surface [nucleotide binding]; other site
1074919004783	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919004784	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919004785	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919004786	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1074919004787	active site
1074919004788	catalytic site [active]
1074919004789	OsmC-like protein; Region: OsmC; cl00767
1074919004790	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1074919004791	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919004792	catalytic residue [active]
1074919004793	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
1074919004794	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1074919004795	ligand binding site [chemical binding]; other site
1074919004796	NAD binding site [chemical binding]; other site
1074919004797	dimerization interface [polypeptide binding]; other site
1074919004798	catalytic site [active]
1074919004799	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1074919004800	putative L-serine binding site [chemical binding]; other site
1074919004801	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1074919004802	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919004803	motif II; other site
1074919004804	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1074919004805	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919004806	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919004807	active site turn [active]
1074919004808	phosphorylation site [posttranslational modification]
1074919004809	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1074919004810	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1074919004811	putative acyl-acceptor binding pocket; other site
1074919004812	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1074919004813	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1074919004814	protein binding site [polypeptide binding]; other site
1074919004815	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1074919004816	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1074919004817	active site
1074919004818	HIGH motif; other site
1074919004819	dimer interface [polypeptide binding]; other site
1074919004820	KMSKS motif; other site
1074919004821	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919004822	RNA binding surface [nucleotide binding]; other site
1074919004823	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1074919004824	Transglycosylase; Region: Transgly; pfam00912
1074919004825	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
1074919004826	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1074919004827	NEAr Transporter domain; Region: NEAT; smart00725
1074919004828	NEAr Transporter domain; Region: NEAT; smart00725
1074919004829	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1074919004830	heme-binding site [chemical binding]; other site
1074919004831	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1074919004832	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1074919004833	Potassium binding sites [ion binding]; other site
1074919004834	Cesium cation binding sites [ion binding]; other site
1074919004835	acetyl-CoA synthetase; Provisional; Region: PRK04319
1074919004836	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1074919004837	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1074919004838	active site
1074919004839	acyl-activating enzyme (AAE) consensus motif; other site
1074919004840	putative CoA binding site [chemical binding]; other site
1074919004841	AMP binding site [chemical binding]; other site
1074919004842	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1074919004843	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1074919004844	active site
1074919004845	Zn binding site [ion binding]; other site
1074919004846	catabolite control protein A; Region: ccpA; TIGR01481
1074919004847	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1074919004848	DNA binding site [nucleotide binding]
1074919004849	domain linker motif; other site
1074919004850	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1074919004851	dimerization interface [polypeptide binding]; other site
1074919004852	effector binding site; other site
1074919004853	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1074919004854	Chorismate mutase type II; Region: CM_2; cl00693
1074919004855	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1074919004856	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1074919004857	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1074919004858	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1074919004859	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919004860	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919004861	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1074919004862	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074919004863	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1074919004864	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1074919004865	putative tRNA-binding site [nucleotide binding]; other site
1074919004866	hypothetical protein; Provisional; Region: PRK13668
1074919004867	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1074919004868	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1074919004869	oligomer interface [polypeptide binding]; other site
1074919004870	active site
1074919004871	metal binding site [ion binding]; metal-binding site
1074919004872	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1074919004873	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004874	S-adenosylmethionine binding site [chemical binding]; other site
1074919004875	Phosphotransferase enzyme family; Region: APH; pfam01636
1074919004876	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1074919004877	active site
1074919004878	substrate binding site [chemical binding]; other site
1074919004879	ATP binding site [chemical binding]; other site
1074919004880	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1074919004881	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1074919004882	homodimer interface [polypeptide binding]; other site
1074919004883	substrate-cofactor binding pocket; other site
1074919004884	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919004885	catalytic residue [active]
1074919004886	dipeptidase PepV; Reviewed; Region: PRK07318
1074919004887	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1074919004888	active site
1074919004889	metal binding site [ion binding]; metal-binding site
1074919004890	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1074919004891	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919004892	RNA binding surface [nucleotide binding]; other site
1074919004893	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1074919004894	active site
1074919004895	uracil binding [chemical binding]; other site
1074919004896	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1074919004897	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1074919004898	HI0933-like protein; Region: HI0933_like; pfam03486
1074919004899	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919004900	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1074919004901	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004902	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004903	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004904	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004905	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004906	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004907	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004908	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004909	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004910	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004911	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004912	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004913	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004914	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004915	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004916	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1074919004917	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1074919004918	HIGH motif; other site
1074919004919	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1074919004920	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1074919004921	active site
1074919004922	KMSKS motif; other site
1074919004923	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1074919004924	tRNA binding surface [nucleotide binding]; other site
1074919004925	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919004926	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919004927	putative substrate translocation pore; other site
1074919004928	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1074919004929	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1074919004930	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919004931	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1074919004932	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074919004933	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1074919004934	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1074919004935	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1074919004936	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1074919004937	dimerization interface [polypeptide binding]; other site
1074919004938	active site
1074919004939	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1074919004940	Lumazine binding domain; Region: Lum_binding; pfam00677
1074919004941	Lumazine binding domain; Region: Lum_binding; pfam00677
1074919004942	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1074919004943	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1074919004944	catalytic motif [active]
1074919004945	Zn binding site [ion binding]; other site
1074919004946	RibD C-terminal domain; Region: RibD_C; cl17279
1074919004947	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1074919004948	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1074919004949	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1074919004950	arsenical pump membrane protein; Provisional; Region: PRK15445
1074919004951	transmembrane helices; other site
1074919004952	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1074919004953	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1074919004954	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1074919004955	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1074919004956	DNA binding residues [nucleotide binding]
1074919004957	CAAX protease self-immunity; Region: Abi; pfam02517
1074919004958	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1074919004959	active site
1074919004960	intersubunit interactions; other site
1074919004961	catalytic residue [active]
1074919004962	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1074919004963	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919004964	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074919004965	active site
1074919004966	catalytic tetrad [active]
1074919004967	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1074919004968	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1074919004969	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1074919004970	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1074919004971	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1074919004972	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1074919004973	active site
1074919004974	substrate-binding site [chemical binding]; other site
1074919004975	metal-binding site [ion binding]
1074919004976	ATP binding site [chemical binding]; other site
1074919004977	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1074919004978	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1074919004979	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
1074919004980	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
1074919004981	nudix motif; other site
1074919004982	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1074919004983	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1074919004984	metal binding site [ion binding]; metal-binding site
1074919004985	substrate binding pocket [chemical binding]; other site
1074919004986	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1074919004987	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
1074919004988	acyl-activating enzyme (AAE) consensus motif; other site
1074919004989	putative AMP binding site [chemical binding]; other site
1074919004990	putative active site [active]
1074919004991	putative CoA binding site [chemical binding]; other site
1074919004992	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1074919004993	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1074919004994	Integrase core domain; Region: rve; pfam00665
1074919004995	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1074919004996	Integrase core domain; Region: rve_3; pfam13683
1074919004997	Winged helix-turn helix; Region: HTH_29; pfam13551
1074919004998	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1074919004999	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1074919005000	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1074919005001	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1074919005002	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1074919005003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919005004	S-adenosylmethionine binding site [chemical binding]; other site
1074919005005	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919005006	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1074919005007	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1074919005008	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919005009	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919005010	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919005011	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919005012	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1074919005013	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1074919005014	beta-channel forming cytolysin; Region: hlyII; TIGR01002
1074919005015	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1074919005016	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1074919005017	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1074919005018	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1074919005019	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1074919005020	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005021	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005022	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005023	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005024	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005025	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005026	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005027	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005028	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005029	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005030	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1074919005031	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1074919005032	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1074919005033	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074919005034	ferrochelatase; Provisional; Region: PRK12435
1074919005035	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1074919005036	C-terminal domain interface [polypeptide binding]; other site
1074919005037	active site
1074919005038	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1074919005039	active site
1074919005040	N-terminal domain interface [polypeptide binding]; other site
1074919005041	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1074919005042	substrate binding site [chemical binding]; other site
1074919005043	active site
1074919005044	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1074919005045	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1074919005046	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1074919005047	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919005048	Walker A/P-loop; other site
1074919005049	ATP binding site [chemical binding]; other site
1074919005050	Q-loop/lid; other site
1074919005051	ABC transporter signature motif; other site
1074919005052	Walker B; other site
1074919005053	D-loop; other site
1074919005054	H-loop/switch region; other site
1074919005055	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1074919005056	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
1074919005057	SurA N-terminal domain; Region: SurA_N_3; cl07813
1074919005058	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1074919005059	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1074919005060	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1074919005061	generic binding surface I; other site
1074919005062	generic binding surface II; other site
1074919005063	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919005064	Zn2+ binding site [ion binding]; other site
1074919005065	Mg2+ binding site [ion binding]; other site
1074919005066	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1074919005067	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
1074919005068	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1074919005069	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1074919005070	active site
1074919005071	metal binding site [ion binding]; metal-binding site
1074919005072	DNA binding site [nucleotide binding]
1074919005073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1074919005074	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074919005075	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919005076	non-specific DNA binding site [nucleotide binding]; other site
1074919005077	salt bridge; other site
1074919005078	sequence-specific DNA binding site [nucleotide binding]; other site
1074919005079	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074919005080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919005081	active site
1074919005082	phosphorylation site [posttranslational modification]
1074919005083	intermolecular recognition site; other site
1074919005084	dimerization interface [polypeptide binding]; other site
1074919005085	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074919005086	DNA binding residues [nucleotide binding]
1074919005087	dimerization interface [polypeptide binding]; other site
1074919005088	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1074919005089	GAF domain; Region: GAF_3; pfam13492
1074919005090	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074919005091	Histidine kinase; Region: HisKA_3; pfam07730
1074919005092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919005093	ATP binding site [chemical binding]; other site
1074919005094	Mg2+ binding site [ion binding]; other site
1074919005095	G-X-G motif; other site
1074919005096	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1074919005097	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1074919005098	active site
1074919005099	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1074919005100	Class II fumarases; Region: Fumarase_classII; cd01362
1074919005101	active site
1074919005102	tetramer interface [polypeptide binding]; other site
1074919005103	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
1074919005104	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1074919005105	active site
1074919005106	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1074919005107	epoxyqueuosine reductase; Region: TIGR00276
1074919005108	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1074919005109	HEAT repeats; Region: HEAT_2; pfam13646
1074919005110	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919005111	ABC transporter; Region: ABC_tran; pfam00005
1074919005112	Q-loop/lid; other site
1074919005113	ABC transporter signature motif; other site
1074919005114	Walker B; other site
1074919005115	D-loop; other site
1074919005116	H-loop/switch region; other site
1074919005117	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1074919005118	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1074919005119	substrate binding pocket [chemical binding]; other site
1074919005120	membrane-bound complex binding site; other site
1074919005121	hinge residues; other site
1074919005122	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1074919005123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919005124	dimer interface [polypeptide binding]; other site
1074919005125	conserved gate region; other site
1074919005126	putative PBP binding loops; other site
1074919005127	ABC-ATPase subunit interface; other site
1074919005128	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1074919005129	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1074919005130	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919005131	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919005132	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
1074919005133	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1074919005134	putative ligand binding site [chemical binding]; other site
1074919005135	NAD binding site [chemical binding]; other site
1074919005136	catalytic site [active]
1074919005137	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1074919005138	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1074919005139	catalytic triad [active]
1074919005140	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1074919005141	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919005142	inhibitor-cofactor binding pocket; inhibition site
1074919005143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919005144	catalytic residue [active]
1074919005145	Predicted membrane protein [Function unknown]; Region: COG4129
1074919005146	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1074919005147	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1074919005148	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919005149	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1074919005150	Walker A/P-loop; other site
1074919005151	ATP binding site [chemical binding]; other site
1074919005152	Q-loop/lid; other site
1074919005153	ABC transporter signature motif; other site
1074919005154	Walker B; other site
1074919005155	D-loop; other site
1074919005156	H-loop/switch region; other site
1074919005157	hypothetical protein; Provisional; Region: PRK13662
1074919005158	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1074919005159	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1074919005160	minor groove reading motif; other site
1074919005161	helix-hairpin-helix signature motif; other site
1074919005162	substrate binding pocket [chemical binding]; other site
1074919005163	active site
1074919005164	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1074919005165	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1074919005166	DNA binding and oxoG recognition site [nucleotide binding]
1074919005167	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1074919005168	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1074919005169	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919005170	Walker A/P-loop; other site
1074919005171	ATP binding site [chemical binding]; other site
1074919005172	Q-loop/lid; other site
1074919005173	ABC transporter signature motif; other site
1074919005174	Walker B; other site
1074919005175	H-loop/switch region; other site
1074919005176	recombination regulator RecX; Provisional; Region: recX; PRK14135
1074919005177	glycosyltransferase; Provisional; Region: PRK13481
1074919005178	Transglycosylase; Region: Transgly; pfam00912
1074919005179	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1074919005180	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1074919005181	proposed catalytic triad [active]
1074919005182	conserved cys residue [active]
1074919005183	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1074919005184	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919005185	FeS/SAM binding site; other site
1074919005186	YfkB-like domain; Region: YfkB; pfam08756
1074919005187	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1074919005188	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1074919005189	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1074919005190	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1074919005191	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1074919005192	active site
1074919005193	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1074919005194	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074919005195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919005196	active site
1074919005197	phosphorylation site [posttranslational modification]
1074919005198	intermolecular recognition site; other site
1074919005199	dimerization interface [polypeptide binding]; other site
1074919005200	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074919005201	DNA binding residues [nucleotide binding]
1074919005202	dimerization interface [polypeptide binding]; other site
1074919005203	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074919005204	Histidine kinase; Region: HisKA_3; pfam07730
1074919005205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919005206	ATP binding site [chemical binding]; other site
1074919005207	Mg2+ binding site [ion binding]; other site
1074919005208	G-X-G motif; other site
1074919005209	Predicted membrane protein [Function unknown]; Region: COG4758
1074919005210	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1074919005211	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1074919005212	active site
1074919005213	Predicted membrane protein [Function unknown]; Region: COG4129
1074919005214	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1074919005215	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1074919005216	catalytic triad [active]
1074919005217	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1074919005218	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919005219	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1074919005220	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1074919005221	Ferritin-like domain; Region: Ferritin; pfam00210
1074919005222	ferroxidase diiron center [ion binding]; other site
1074919005223	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1074919005224	active site
1074919005225	catalytic site [active]
1074919005226	substrate binding site [chemical binding]; other site
1074919005227	DNA polymerase IV; Validated; Region: PRK02406
1074919005228	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1074919005229	active site
1074919005230	DNA binding site [nucleotide binding]
1074919005231	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1074919005232	TRAM domain; Region: TRAM; cl01282
1074919005233	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1074919005234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919005235	S-adenosylmethionine binding site [chemical binding]; other site
1074919005236	putative lipid kinase; Reviewed; Region: PRK13337
1074919005237	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1074919005238	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
1074919005239	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1074919005240	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1074919005241	GatB domain; Region: GatB_Yqey; pfam02637
1074919005242	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1074919005243	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1074919005244	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1074919005245	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1074919005246	Na binding site [ion binding]; other site
1074919005247	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
1074919005248	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1074919005249	putative dimer interface [polypeptide binding]; other site
1074919005250	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1074919005251	putative dimer interface [polypeptide binding]; other site
1074919005252	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1074919005253	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1074919005254	nucleotide binding pocket [chemical binding]; other site
1074919005255	K-X-D-G motif; other site
1074919005256	catalytic site [active]
1074919005257	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1074919005258	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1074919005259	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1074919005260	Dimer interface [polypeptide binding]; other site
1074919005261	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1074919005262	Part of AAA domain; Region: AAA_19; pfam13245
1074919005263	Family description; Region: UvrD_C_2; pfam13538
1074919005264	PcrB family; Region: PcrB; pfam01884
1074919005265	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1074919005266	substrate binding site [chemical binding]; other site
1074919005267	putative active site [active]
1074919005268	dimer interface [polypeptide binding]; other site
1074919005269	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1074919005270	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1074919005271	tetramer interface [polypeptide binding]; other site
1074919005272	active site
1074919005273	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1074919005274	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1074919005275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
1074919005276	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1074919005277	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1074919005278	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1074919005279	homodimer interface [polypeptide binding]; other site
1074919005280	NAD binding pocket [chemical binding]; other site
1074919005281	ATP binding pocket [chemical binding]; other site
1074919005282	Mg binding site [ion binding]; other site
1074919005283	active-site loop [active]
1074919005284	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1074919005285	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1074919005286	active site
1074919005287	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
1074919005288	active site
1074919005289	dimer interface [polypeptide binding]; other site
1074919005290	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1074919005291	Prephenate dehydratase; Region: PDT; pfam00800
1074919005292	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1074919005293	putative L-Phe binding site [chemical binding]; other site
1074919005294	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1074919005295	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1074919005296	transmembrane helices; other site
1074919005297	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1074919005298	Isochorismatase family; Region: Isochorismatase; pfam00857
1074919005299	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1074919005300	catalytic triad [active]
1074919005301	conserved cis-peptide bond; other site
1074919005302	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1074919005303	DHH family; Region: DHH; pfam01368
1074919005304	DHHA2 domain; Region: DHHA2; pfam02833
1074919005305	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1074919005306	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1074919005307	NAD(P) binding site [chemical binding]; other site
1074919005308	catalytic residues [active]
1074919005309	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
1074919005310	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
1074919005311	active site
1074919005312	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
1074919005313	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1074919005314	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1074919005315	Bacterial PH domain; Region: DUF304; cl01348
1074919005316	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
1074919005317	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919005318	ABC transporter; Region: ABC_tran; pfam00005
1074919005319	Q-loop/lid; other site
1074919005320	ABC transporter signature motif; other site
1074919005321	Walker B; other site
1074919005322	D-loop; other site
1074919005323	H-loop/switch region; other site
1074919005324	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1074919005325	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074919005326	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919005327	Walker A/P-loop; other site
1074919005328	ATP binding site [chemical binding]; other site
1074919005329	Q-loop/lid; other site
1074919005330	ABC transporter signature motif; other site
1074919005331	Walker B; other site
1074919005332	D-loop; other site
1074919005333	H-loop/switch region; other site
1074919005334	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1074919005335	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919005336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919005337	homodimer interface [polypeptide binding]; other site
1074919005338	catalytic residue [active]
1074919005339	MAP domain; Region: MAP; pfam03642
1074919005340	MAP domain; Region: MAP; pfam03642
1074919005341	MAP domain; Region: MAP; pfam03642
1074919005342	MAP domain; Region: MAP; pfam03642
1074919005343	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
1074919005344	CHAP domain; Region: CHAP; pfam05257
1074919005345	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005346	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005347	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
1074919005348	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1074919005349	Phage tail protein; Region: Sipho_tail; cl17486
1074919005350	Phage tail protein; Region: Sipho_tail; cl17486
1074919005351	Phage-related minor tail protein [Function unknown]; Region: COG5280
1074919005352	Phage-related protein [Function unknown]; Region: COG5412
1074919005353	Peptidase family M23; Region: Peptidase_M23; pfam01551
1074919005354	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074919005355	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1074919005356	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1074919005357	catalytic residue [active]
1074919005358	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1074919005359	Phage capsid family; Region: Phage_capsid; pfam05065
1074919005360	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1074919005361	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1074919005362	oligomer interface [polypeptide binding]; other site
1074919005363	active site residues [active]
1074919005364	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1074919005365	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1074919005366	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1074919005367	dUTPase; Region: dUTPase_2; pfam08761
1074919005368	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1074919005369	active site
1074919005370	homodimer interface [polypeptide binding]; other site
1074919005371	metal binding site [ion binding]; metal-binding site
1074919005372	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
1074919005373	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1074919005374	Walker A motif; other site
1074919005375	ATP binding site [chemical binding]; other site
1074919005376	Walker B motif; other site
1074919005377	DNA binding loops [nucleotide binding]
1074919005378	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1074919005379	Protein of unknown function (DUF968); Region: DUF968; pfam06147
1074919005380	NUMOD4 motif; Region: NUMOD4; pfam07463
1074919005381	HNH endonuclease; Region: HNH_3; pfam13392
1074919005382	Protein of unknown function (DUF1071); Region: DUF1071; pfam06378
1074919005383	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1074919005384	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1074919005385	ring oligomerisation interface [polypeptide binding]; other site
1074919005386	ATP/Mg binding site [chemical binding]; other site
1074919005387	stacking interactions; other site
1074919005388	hinge regions; other site
1074919005389	CAAX protease self-immunity; Region: Abi; pfam02517
1074919005390	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1074919005391	dimer interface [polypeptide binding]; other site
1074919005392	FMN binding site [chemical binding]; other site
1074919005393	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1074919005394	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1074919005395	putative active site [active]
1074919005396	catalytic triad [active]
1074919005397	putative dimer interface [polypeptide binding]; other site
1074919005398	Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512
1074919005399	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1074919005400	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1074919005401	Mg2+ binding site [ion binding]; other site
1074919005402	G-X-G motif; other site
1074919005403	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1074919005404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919005405	active site
1074919005406	phosphorylation site [posttranslational modification]
1074919005407	intermolecular recognition site; other site
1074919005408	dimerization interface [polypeptide binding]; other site
1074919005409	LytTr DNA-binding domain; Region: LytTR; pfam04397
1074919005410	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1074919005411	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1074919005412	putative ATP binding site [chemical binding]; other site
1074919005413	putative substrate binding site [chemical binding]; other site
1074919005414	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1074919005415	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1074919005416	substrate binding [chemical binding]; other site
1074919005417	active site
1074919005418	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1074919005419	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1074919005420	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1074919005421	DNA binding site [nucleotide binding]
1074919005422	domain linker motif; other site
1074919005423	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1074919005424	dimerization interface [polypeptide binding]; other site
1074919005425	ligand binding site [chemical binding]; other site
1074919005426	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1074919005427	Predicted transporter component [General function prediction only]; Region: COG2391
1074919005428	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
1074919005429	Sulphur transport; Region: Sulf_transp; pfam04143
1074919005430	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
1074919005431	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1074919005432	CoA binding domain; Region: CoA_binding; pfam02629
1074919005433	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1074919005434	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919005435	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919005436	ABC transporter; Region: ABC_tran_2; pfam12848
1074919005437	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919005438	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
1074919005439	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
1074919005440	Walker A/P-loop; other site
1074919005441	ATP binding site [chemical binding]; other site
1074919005442	Q-loop/lid; other site
1074919005443	ABC transporter signature motif; other site
1074919005444	Walker B; other site
1074919005445	D-loop; other site
1074919005446	H-loop/switch region; other site
1074919005447	UGMP family protein; Validated; Region: PRK09604
1074919005448	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1074919005449	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1074919005450	Glycoprotease family; Region: Peptidase_M22; pfam00814
1074919005451	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1074919005452	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1074919005453	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1074919005454	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
1074919005455	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1074919005456	PYR/PP interface [polypeptide binding]; other site
1074919005457	dimer interface [polypeptide binding]; other site
1074919005458	TPP binding site [chemical binding]; other site
1074919005459	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074919005460	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1074919005461	TPP-binding site [chemical binding]; other site
1074919005462	dimer interface [polypeptide binding]; other site
1074919005463	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1074919005464	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1074919005465	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1074919005466	2-isopropylmalate synthase; Validated; Region: PRK00915
1074919005467	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1074919005468	active site
1074919005469	catalytic residues [active]
1074919005470	metal binding site [ion binding]; metal-binding site
1074919005471	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1074919005472	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1074919005473	tartrate dehydrogenase; Region: TTC; TIGR02089
1074919005474	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1074919005475	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1074919005476	substrate binding site [chemical binding]; other site
1074919005477	ligand binding site [chemical binding]; other site
1074919005478	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1074919005479	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1074919005480	substrate binding site [chemical binding]; other site
1074919005481	threonine dehydratase; Validated; Region: PRK08639
1074919005482	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1074919005483	tetramer interface [polypeptide binding]; other site
1074919005484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919005485	catalytic residue [active]
1074919005486	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1074919005487	putative Ile/Val binding site [chemical binding]; other site
1074919005488	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1074919005489	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1074919005490	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1074919005491	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1074919005492	RNA binding site [nucleotide binding]; other site
1074919005493	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074919005494	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1074919005495	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074919005496	DNA binding residues [nucleotide binding]
1074919005497	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1074919005498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919005499	ATP binding site [chemical binding]; other site
1074919005500	Mg2+ binding site [ion binding]; other site
1074919005501	G-X-G motif; other site
1074919005502	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1074919005503	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
1074919005504	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1074919005505	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1074919005506	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1074919005507	active site
1074919005508	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919005509	dimer interface [polypeptide binding]; other site
1074919005510	substrate binding site [chemical binding]; other site
1074919005511	catalytic residues [active]
1074919005512	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1074919005513	Predicted membrane protein [Function unknown]; Region: COG3428
1074919005514	Bacterial PH domain; Region: DUF304; pfam03703
1074919005515	Bacterial PH domain; Region: DUF304; pfam03703
1074919005516	Bacterial PH domain; Region: DUF304; cl01348
1074919005517	potassium-transporting ATPase subunit C; Provisional; Region: PRK13998
1074919005518	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
1074919005519	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1074919005520	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1074919005521	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
1074919005522	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1074919005523	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1074919005524	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1074919005525	Ligand Binding Site [chemical binding]; other site
1074919005526	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919005527	dimer interface [polypeptide binding]; other site
1074919005528	phosphorylation site [posttranslational modification]
1074919005529	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919005530	ATP binding site [chemical binding]; other site
1074919005531	Mg2+ binding site [ion binding]; other site
1074919005532	G-X-G motif; other site
1074919005533	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919005534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919005535	active site
1074919005536	phosphorylation site [posttranslational modification]
1074919005537	intermolecular recognition site; other site
1074919005538	dimerization interface [polypeptide binding]; other site
1074919005539	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919005540	DNA binding site [nucleotide binding]
1074919005541	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919005542	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919005543	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1074919005544	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1074919005545	ATP binding site [chemical binding]; other site
1074919005546	Mg++ binding site [ion binding]; other site
1074919005547	motif III; other site
1074919005548	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919005549	nucleotide binding region [chemical binding]; other site
1074919005550	ATP-binding site [chemical binding]; other site
1074919005551	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1074919005552	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1074919005553	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919005554	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919005555	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1074919005556	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1074919005557	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1074919005558	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1074919005559	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1074919005560	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1074919005561	putative active site [active]
1074919005562	catalytic site [active]
1074919005563	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1074919005564	putative active site [active]
1074919005565	catalytic site [active]
1074919005566	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1074919005567	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919005568	Zn2+ binding site [ion binding]; other site
1074919005569	Mg2+ binding site [ion binding]; other site
1074919005570	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1074919005571	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1074919005572	thiamine phosphate binding site [chemical binding]; other site
1074919005573	active site
1074919005574	pyrophosphate binding site [ion binding]; other site
1074919005575	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1074919005576	multimerization interface [polypeptide binding]; other site
1074919005577	ATP binding site [chemical binding]; other site
1074919005578	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1074919005579	substrate binding site [chemical binding]; other site
1074919005580	dimer interface [polypeptide binding]; other site
1074919005581	ATP binding site [chemical binding]; other site
1074919005582	thiaminase II; Region: salvage_TenA; TIGR04306
1074919005583	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1074919005584	YwpF-like protein; Region: YwpF; pfam14183
1074919005585	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1074919005586	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1074919005587	hinge; other site
1074919005588	active site
1074919005589	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1074919005590	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1074919005591	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1074919005592	alpha subunit interaction interface [polypeptide binding]; other site
1074919005593	Walker A motif; other site
1074919005594	ATP binding site [chemical binding]; other site
1074919005595	Walker B motif; other site
1074919005596	inhibitor binding site; inhibition site
1074919005597	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1074919005598	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1074919005599	core domain interface [polypeptide binding]; other site
1074919005600	delta subunit interface [polypeptide binding]; other site
1074919005601	epsilon subunit interface [polypeptide binding]; other site
1074919005602	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1074919005603	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1074919005604	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1074919005605	beta subunit interaction interface [polypeptide binding]; other site
1074919005606	Walker A motif; other site
1074919005607	ATP binding site [chemical binding]; other site
1074919005608	Walker B motif; other site
1074919005609	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1074919005610	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1074919005611	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1074919005612	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
1074919005613	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1074919005614	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1074919005615	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1074919005616	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1074919005617	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1074919005618	active site
1074919005619	homodimer interface [polypeptide binding]; other site
1074919005620	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919005621	active site
1074919005622	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1074919005623	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1074919005624	dimer interface [polypeptide binding]; other site
1074919005625	active site
1074919005626	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1074919005627	folate binding site [chemical binding]; other site
1074919005628	hypothetical protein; Provisional; Region: PRK13690
1074919005629	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1074919005630	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1074919005631	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1074919005632	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919005633	S-adenosylmethionine binding site [chemical binding]; other site
1074919005634	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1074919005635	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1074919005636	RF-1 domain; Region: RF-1; pfam00472
1074919005637	thymidine kinase; Provisional; Region: PRK04296
1074919005638	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1074919005639	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1074919005640	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1074919005641	RNA binding site [nucleotide binding]; other site
1074919005642	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1074919005643	multimer interface [polypeptide binding]; other site
1074919005644	Walker A motif; other site
1074919005645	ATP binding site [chemical binding]; other site
1074919005646	Walker B motif; other site
1074919005647	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1074919005648	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1074919005649	NAD binding site [chemical binding]; other site
1074919005650	catalytic residues [active]
1074919005651	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1074919005652	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1074919005653	hinge; other site
1074919005654	active site
1074919005655	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1074919005656	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1074919005657	intersubunit interface [polypeptide binding]; other site
1074919005658	active site
1074919005659	zinc binding site [ion binding]; other site
1074919005660	Na+ binding site [ion binding]; other site
1074919005661	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1074919005662	CTP synthetase; Validated; Region: pyrG; PRK05380
1074919005663	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1074919005664	Catalytic site [active]
1074919005665	active site
1074919005666	UTP binding site [chemical binding]; other site
1074919005667	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1074919005668	active site
1074919005669	putative oxyanion hole; other site
1074919005670	catalytic triad [active]
1074919005671	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1074919005672	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919005673	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1074919005674	Coenzyme A binding pocket [chemical binding]; other site
1074919005675	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919005676	Coenzyme A binding pocket [chemical binding]; other site
1074919005677	pantothenate kinase; Provisional; Region: PRK13317
1074919005678	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
1074919005679	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1074919005680	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1074919005681	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074919005682	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1074919005683	metal binding site [ion binding]; metal-binding site
1074919005684	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1074919005685	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1074919005686	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1074919005687	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1074919005688	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1074919005689	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1074919005690	intersubunit interface [polypeptide binding]; other site
1074919005691	active site
1074919005692	catalytic residue [active]
1074919005693	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1074919005694	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1074919005695	EVE domain; Region: EVE; cl00728
1074919005696	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1074919005697	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1074919005698	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1074919005699	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1074919005700	NAD(P) binding site [chemical binding]; other site
1074919005701	putative active site [active]
1074919005702	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1074919005703	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1074919005704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919005705	S-adenosylmethionine binding site [chemical binding]; other site
1074919005706	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1074919005707	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919005708	S-adenosylmethionine binding site [chemical binding]; other site
1074919005709	aminoglycoside resistance protein; Provisional; Region: PRK13746
1074919005710	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1074919005711	active site
1074919005712	NTP binding site [chemical binding]; other site
1074919005713	metal binding triad [ion binding]; metal-binding site
1074919005714	antibiotic binding site [chemical binding]; other site
1074919005715	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1074919005716	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919005717	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919005718	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919005719	active site
1074919005720	DNA binding site [nucleotide binding]
1074919005721	Int/Topo IB signature motif; other site
1074919005722	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919005723	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1074919005724	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1074919005725	Int/Topo IB signature motif; other site
1074919005726	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1074919005727	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919005728	active site
1074919005729	motif I; other site
1074919005730	motif II; other site
1074919005731	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919005732	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074919005733	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919005734	Walker A/P-loop; other site
1074919005735	ATP binding site [chemical binding]; other site
1074919005736	Q-loop/lid; other site
1074919005737	ABC transporter signature motif; other site
1074919005738	Walker B; other site
1074919005739	D-loop; other site
1074919005740	H-loop/switch region; other site
1074919005741	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1074919005742	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1074919005743	glutaminase active site [active]
1074919005744	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1074919005745	dimer interface [polypeptide binding]; other site
1074919005746	active site
1074919005747	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1074919005748	dimer interface [polypeptide binding]; other site
1074919005749	active site
1074919005750	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1074919005751	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1074919005752	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1074919005753	active site
1074919005754	P-loop; other site
1074919005755	phosphorylation site [posttranslational modification]
1074919005756	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919005757	HTH domain; Region: HTH_11; pfam08279
1074919005758	Mga helix-turn-helix domain; Region: Mga; pfam05043
1074919005759	PRD domain; Region: PRD; pfam00874
1074919005760	PRD domain; Region: PRD; pfam00874
1074919005761	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1074919005762	active site
1074919005763	P-loop; other site
1074919005764	phosphorylation site [posttranslational modification]
1074919005765	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1074919005766	active site
1074919005767	phosphorylation site [posttranslational modification]
1074919005768	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1074919005769	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1074919005770	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1074919005771	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919005772	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1074919005773	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005774	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005775	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005776	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005777	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005778	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005779	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005780	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1074919005781	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1074919005782	active site
1074919005783	substrate binding site [chemical binding]; other site
1074919005784	metal binding site [ion binding]; metal-binding site
1074919005785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1074919005786	YbbR-like protein; Region: YbbR; pfam07949
1074919005787	TIGR00159 family protein; Region: TIGR00159
1074919005788	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1074919005789	Arginase family; Region: Arginase; cd09989
1074919005790	active site
1074919005791	Mn binding site [ion binding]; other site
1074919005792	oligomer interface [polypeptide binding]; other site
1074919005793	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1074919005794	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1074919005795	Walker A motif; other site
1074919005796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1074919005797	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005798	putative substrate translocation pore; other site
1074919005799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005800	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919005801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005802	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1074919005803	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1074919005804	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
1074919005805	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
1074919005806	substrate binding site; other site
1074919005807	dimerization interface; other site
1074919005808	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1074919005809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1074919005810	Nucleoside recognition; Region: Gate; pfam07670
1074919005811	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074919005812	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919005813	ABC-ATPase subunit  interface; other site
1074919005814	dimer interface [polypeptide binding]; other site
1074919005815	putative PBP binding regions; other site
1074919005816	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1074919005817	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919005818	ABC-ATPase subunit  interface; other site
1074919005819	dimer interface [polypeptide binding]; other site
1074919005820	putative PBP binding regions; other site
1074919005821	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1074919005822	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1074919005823	siderophore binding site; other site
1074919005824	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
1074919005825	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
1074919005826	dimer interface [polypeptide binding]; other site
1074919005827	active site
1074919005828	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919005829	substrate binding site [chemical binding]; other site
1074919005830	catalytic residue [active]
1074919005831	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919005832	IucA / IucC family; Region: IucA_IucC; pfam04183
1074919005833	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919005834	H+ Antiporter protein; Region: 2A0121; TIGR00900
1074919005835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005836	putative substrate translocation pore; other site
1074919005837	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919005838	IucA / IucC family; Region: IucA_IucC; pfam04183
1074919005839	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919005840	Asp23 family; Region: Asp23; pfam03780
1074919005841	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1074919005842	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1074919005843	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1074919005844	putative NAD(P) binding site [chemical binding]; other site
1074919005845	dimer interface [polypeptide binding]; other site
1074919005846	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1074919005847	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1074919005848	NAD(P) binding site [chemical binding]; other site
1074919005849	substrate binding site [chemical binding]; other site
1074919005850	dimer interface [polypeptide binding]; other site
1074919005851	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
1074919005852	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1074919005853	beta-galactosidase; Region: BGL; TIGR03356
1074919005854	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
1074919005855	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1074919005856	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1074919005857	active site
1074919005858	P-loop; other site
1074919005859	phosphorylation site [posttranslational modification]
1074919005860	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1074919005861	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1074919005862	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1074919005863	putative substrate binding site [chemical binding]; other site
1074919005864	putative ATP binding site [chemical binding]; other site
1074919005865	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1074919005866	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1074919005867	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1074919005868	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1074919005869	NAD-dependent deacetylase; Provisional; Region: PRK00481
1074919005870	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
1074919005871	NAD+ binding site [chemical binding]; other site
1074919005872	substrate binding site [chemical binding]; other site
1074919005873	putative Zn binding site [ion binding]; other site
1074919005874	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919005875	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074919005876	active site
1074919005877	catalytic tetrad [active]
1074919005878	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1074919005879	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1074919005880	DNA binding residues [nucleotide binding]
1074919005881	putative dimer interface [polypeptide binding]; other site
1074919005882	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1074919005883	substrate binding site [chemical binding]; other site
1074919005884	catalytic residues [active]
1074919005885	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074919005886	Peptidase family M23; Region: Peptidase_M23; pfam01551
1074919005887	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1074919005888	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1074919005889	active site
1074919005890	motif I; other site
1074919005891	motif II; other site
1074919005892	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1074919005893	acetolactate synthase; Reviewed; Region: PRK08617
1074919005894	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1074919005895	PYR/PP interface [polypeptide binding]; other site
1074919005896	dimer interface [polypeptide binding]; other site
1074919005897	TPP binding site [chemical binding]; other site
1074919005898	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074919005899	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1074919005900	TPP-binding site [chemical binding]; other site
1074919005901	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1074919005902	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
1074919005903	putative active site [active]
1074919005904	putative NTP binding site [chemical binding]; other site
1074919005905	putative nucleic acid binding site [nucleotide binding]; other site
1074919005906	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1074919005907	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1074919005908	dimerization interface 3.5A [polypeptide binding]; other site
1074919005909	active site
1074919005910	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1074919005911	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919005912	Q-loop/lid; other site
1074919005913	ABC transporter signature motif; other site
1074919005914	Walker B; other site
1074919005915	D-loop; other site
1074919005916	H-loop/switch region; other site
1074919005917	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
1074919005918	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919005919	Walker A/P-loop; other site
1074919005920	ATP binding site [chemical binding]; other site
1074919005921	Q-loop/lid; other site
1074919005922	ABC transporter signature motif; other site
1074919005923	Walker B; other site
1074919005924	D-loop; other site
1074919005925	H-loop/switch region; other site
1074919005926	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1074919005927	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1074919005928	alphaNTD homodimer interface [polypeptide binding]; other site
1074919005929	alphaNTD - beta interaction site [polypeptide binding]; other site
1074919005930	alphaNTD - beta' interaction site [polypeptide binding]; other site
1074919005931	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1074919005932	adenylate kinase; Reviewed; Region: adk; PRK00279
1074919005933	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1074919005934	AMP-binding site [chemical binding]; other site
1074919005935	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1074919005936	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1074919005937	SecY translocase; Region: SecY; pfam00344
1074919005938	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
1074919005939	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1074919005940	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1074919005941	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1074919005942	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1074919005943	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1074919005944	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1074919005945	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1074919005946	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1074919005947	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1074919005948	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1074919005949	G-X-X-G motif; other site
1074919005950	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1074919005951	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1074919005952	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1074919005953	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1074919005954	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1074919005955	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1074919005956	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1074919005957	DNA topoisomerase III; Provisional; Region: PRK07726
1074919005958	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1074919005959	active site
1074919005960	putative interdomain interaction site [polypeptide binding]; other site
1074919005961	putative metal-binding site [ion binding]; other site
1074919005962	putative nucleotide binding site [chemical binding]; other site
1074919005963	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1074919005964	domain I; other site
1074919005965	DNA binding groove [nucleotide binding]
1074919005966	phosphate binding site [ion binding]; other site
1074919005967	domain II; other site
1074919005968	domain III; other site
1074919005969	nucleotide binding site [chemical binding]; other site
1074919005970	catalytic site [active]
1074919005971	domain IV; other site
1074919005972	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1074919005973	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919005974	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1074919005975	Coenzyme A binding pocket [chemical binding]; other site
1074919005976	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1074919005977	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1074919005978	Predicted permeases [General function prediction only]; Region: COG0679
1074919005979	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1074919005980	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1074919005981	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1074919005982	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1074919005983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005984	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919005985	putative substrate translocation pore; other site
1074919005986	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1074919005987	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919005988	FeS/SAM binding site; other site
1074919005989	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1074919005990	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1074919005991	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1074919005992	GTP binding site; other site
1074919005993	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
1074919005994	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1074919005995	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1074919005996	dimer interface [polypeptide binding]; other site
1074919005997	putative functional site; other site
1074919005998	putative MPT binding site; other site
1074919005999	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1074919006000	trimer interface [polypeptide binding]; other site
1074919006001	dimer interface [polypeptide binding]; other site
1074919006002	putative active site [active]
1074919006003	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1074919006004	MPT binding site; other site
1074919006005	trimer interface [polypeptide binding]; other site
1074919006006	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1074919006007	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1074919006008	ATP binding site [chemical binding]; other site
1074919006009	substrate interface [chemical binding]; other site
1074919006010	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006011	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1074919006012	Walker A/P-loop; other site
1074919006013	ATP binding site [chemical binding]; other site
1074919006014	Q-loop/lid; other site
1074919006015	ABC transporter signature motif; other site
1074919006016	Walker B; other site
1074919006017	D-loop; other site
1074919006018	H-loop/switch region; other site
1074919006019	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1074919006020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006021	dimer interface [polypeptide binding]; other site
1074919006022	conserved gate region; other site
1074919006023	putative PBP binding loops; other site
1074919006024	ABC-ATPase subunit interface; other site
1074919006025	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1074919006026	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1074919006027	substrate binding pocket [chemical binding]; other site
1074919006028	membrane-bound complex binding site; other site
1074919006029	hinge residues; other site
1074919006030	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1074919006031	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006032	Coenzyme A binding pocket [chemical binding]; other site
1074919006033	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1074919006034	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
1074919006035	active site
1074919006036	dimerization interface [polypeptide binding]; other site
1074919006037	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1074919006038	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074919006039	intersubunit interface [polypeptide binding]; other site
1074919006040	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1074919006041	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1074919006042	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1074919006043	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
1074919006044	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1074919006045	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1074919006046	subunit interactions [polypeptide binding]; other site
1074919006047	active site
1074919006048	flap region; other site
1074919006049	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1074919006050	UreF; Region: UreF; pfam01730
1074919006051	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1074919006052	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1074919006053	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919006054	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919006055	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919006056	Helix-turn-helix domain; Region: HTH_18; pfam12833
1074919006057	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919006058	Surface antigen [General function prediction only]; Region: COG3942
1074919006059	CHAP domain; Region: CHAP; pfam05257
1074919006060	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1074919006061	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1074919006062	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1074919006063	Surface antigen [General function prediction only]; Region: COG3942
1074919006064	CHAP domain; Region: CHAP; pfam05257
1074919006065	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1074919006066	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1074919006067	putative ligand binding site [chemical binding]; other site
1074919006068	putative NAD binding site [chemical binding]; other site
1074919006069	catalytic site [active]
1074919006070	hypothetical protein; Provisional; Region: PRK06753
1074919006071	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1074919006072	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1074919006073	Lysozyme subfamily 2; Region: LYZ2; smart00047
1074919006074	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1074919006075	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1074919006076	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1074919006077	4Fe-4S binding domain; Region: Fer4; pfam00037
1074919006078	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1074919006079	[4Fe-4S] binding site [ion binding]; other site
1074919006080	molybdopterin cofactor binding site; other site
1074919006081	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1074919006082	molybdopterin cofactor binding site; other site
1074919006083	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1074919006084	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1074919006085	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1074919006086	active site
1074919006087	Predicted transcriptional regulator [Transcription]; Region: COG2378
1074919006088	HTH domain; Region: HTH_11; pfam08279
1074919006089	CAAX protease self-immunity; Region: Abi; pfam02517
1074919006090	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919006091	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1074919006092	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1074919006093	putative active site [active]
1074919006094	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1074919006095	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1074919006096	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919006097	active site
1074919006098	motif I; other site
1074919006099	motif II; other site
1074919006100	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1074919006101	Sodium Bile acid symporter family; Region: SBF; pfam01758
1074919006102	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1074919006103	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919006104	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919006105	active site turn [active]
1074919006106	phosphorylation site [posttranslational modification]
1074919006107	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919006108	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1074919006109	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1074919006110	putative active site [active]
1074919006111	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1074919006112	putative hydrophobic ligand binding site [chemical binding]; other site
1074919006113	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1074919006114	oxidoreductase; Provisional; Region: PRK07985
1074919006115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919006116	NAD(P) binding site [chemical binding]; other site
1074919006117	active site
1074919006118	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1074919006119	amidohydrolase; Region: amidohydrolases; TIGR01891
1074919006120	metal binding site [ion binding]; metal-binding site
1074919006121	dimer interface [polypeptide binding]; other site
1074919006122	imidazolonepropionase; Validated; Region: PRK09356
1074919006123	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1074919006124	active site
1074919006125	urocanate hydratase; Provisional; Region: PRK05414
1074919006126	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919006127	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919006128	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1074919006129	dimerization interface [polypeptide binding]; other site
1074919006130	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1074919006131	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
1074919006132	putative active site [active]
1074919006133	putative Mg binding site [ion binding]; other site
1074919006134	formimidoylglutamase; Provisional; Region: PRK13775
1074919006135	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1074919006136	putative active site [active]
1074919006137	putative metal binding site [ion binding]; other site
1074919006138	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1074919006139	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1074919006140	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074919006141	active site
1074919006142	dimer interface [polypeptide binding]; other site
1074919006143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1074919006144	MOSC domain; Region: MOSC; pfam03473
1074919006145	3-alpha domain; Region: 3-alpha; pfam03475
1074919006146	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1074919006147	active site
1074919006148	catalytic residues [active]
1074919006149	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1074919006150	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1074919006151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006152	Walker A/P-loop; other site
1074919006153	ATP binding site [chemical binding]; other site
1074919006154	Q-loop/lid; other site
1074919006155	ABC transporter signature motif; other site
1074919006156	Walker B; other site
1074919006157	D-loop; other site
1074919006158	H-loop/switch region; other site
1074919006159	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1074919006160	Predicted membrane protein [Function unknown]; Region: COG3152
1074919006161	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1074919006162	active site
1074919006163	DNA binding site [nucleotide binding]
1074919006164	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
1074919006165	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1074919006166	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1074919006167	homotetramer interface [polypeptide binding]; other site
1074919006168	FMN binding site [chemical binding]; other site
1074919006169	homodimer contacts [polypeptide binding]; other site
1074919006170	putative active site [active]
1074919006171	putative substrate binding site [chemical binding]; other site
1074919006172	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1074919006173	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1074919006174	oligomer interface [polypeptide binding]; other site
1074919006175	metal binding site [ion binding]; metal-binding site
1074919006176	metal binding site [ion binding]; metal-binding site
1074919006177	putative Cl binding site [ion binding]; other site
1074919006178	aspartate ring; other site
1074919006179	basic sphincter; other site
1074919006180	hydrophobic gate; other site
1074919006181	periplasmic entrance; other site
1074919006182	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1074919006183	active site
1074919006184	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1074919006185	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1074919006186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006187	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1074919006188	putative substrate translocation pore; other site
1074919006189	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1074919006190	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1074919006191	HlyD family secretion protein; Region: HlyD_3; pfam13437
1074919006192	lipoyl-biotinyl attachment site [posttranslational modification]; other site
1074919006193	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1074919006194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006195	putative substrate translocation pore; other site
1074919006196	Predicted membrane protein [Function unknown]; Region: COG4640
1074919006197	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1074919006198	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1074919006199	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1074919006200	putative active site [active]
1074919006201	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919006202	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919006203	Walker A/P-loop; other site
1074919006204	ATP binding site [chemical binding]; other site
1074919006205	Q-loop/lid; other site
1074919006206	ABC transporter signature motif; other site
1074919006207	Walker B; other site
1074919006208	D-loop; other site
1074919006209	H-loop/switch region; other site
1074919006210	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1074919006211	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074919006212	FtsX-like permease family; Region: FtsX; pfam02687
1074919006213	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919006214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919006215	active site
1074919006216	phosphorylation site [posttranslational modification]
1074919006217	intermolecular recognition site; other site
1074919006218	dimerization interface [polypeptide binding]; other site
1074919006219	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919006220	DNA binding site [nucleotide binding]
1074919006221	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919006222	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074919006223	dimerization interface [polypeptide binding]; other site
1074919006224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919006225	dimer interface [polypeptide binding]; other site
1074919006226	phosphorylation site [posttranslational modification]
1074919006227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919006228	ATP binding site [chemical binding]; other site
1074919006229	Mg2+ binding site [ion binding]; other site
1074919006230	G-X-G motif; other site
1074919006231	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1074919006232	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
1074919006233	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1074919006234	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1074919006235	L-lactate permease; Region: Lactate_perm; cl00701
1074919006236	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919006237	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006238	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919006239	Coenzyme A binding pocket [chemical binding]; other site
1074919006240	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1074919006241	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1074919006242	NAD(P) binding site [chemical binding]; other site
1074919006243	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1074919006244	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919006245	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919006246	Predicted membrane protein [Function unknown]; Region: COG1511
1074919006247	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1074919006248	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1074919006249	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1074919006250	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1074919006251	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1074919006252	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1074919006253	Cl binding site [ion binding]; other site
1074919006254	oligomer interface [polypeptide binding]; other site
1074919006255	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1074919006256	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919006257	active site turn [active]
1074919006258	phosphorylation site [posttranslational modification]
1074919006259	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919006260	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1074919006261	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1074919006262	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919006263	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1074919006264	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1074919006265	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1074919006266	MarR family; Region: MarR_2; pfam12802
1074919006267	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1074919006268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006269	putative substrate translocation pore; other site
1074919006270	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
1074919006271	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1074919006272	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074919006273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919006274	active site
1074919006275	phosphorylation site [posttranslational modification]
1074919006276	intermolecular recognition site; other site
1074919006277	dimerization interface [polypeptide binding]; other site
1074919006278	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074919006279	DNA binding residues [nucleotide binding]
1074919006280	dimerization interface [polypeptide binding]; other site
1074919006281	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074919006282	Histidine kinase; Region: HisKA_3; pfam07730
1074919006283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919006284	ATP binding site [chemical binding]; other site
1074919006285	Mg2+ binding site [ion binding]; other site
1074919006286	G-X-G motif; other site
1074919006287	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1074919006288	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1074919006289	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1074919006290	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1074919006291	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1074919006292	[4Fe-4S] binding site [ion binding]; other site
1074919006293	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1074919006294	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1074919006295	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1074919006296	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1074919006297	molybdopterin cofactor binding site; other site
1074919006298	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1074919006299	active site
1074919006300	SAM binding site [chemical binding]; other site
1074919006301	homodimer interface [polypeptide binding]; other site
1074919006302	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1074919006303	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919006304	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919006305	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1074919006306	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1074919006307	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1074919006308	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1074919006309	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1074919006310	putative active site [active]
1074919006311	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1074919006312	active site
1074919006313	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919006314	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006315	Coenzyme A binding pocket [chemical binding]; other site
1074919006316	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1074919006317	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1074919006318	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1074919006319	putative hydrophobic ligand binding site [chemical binding]; other site
1074919006320	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1074919006321	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074919006322	intersubunit interface [polypeptide binding]; other site
1074919006323	YodA lipocalin-like domain; Region: YodA; pfam09223
1074919006324	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1074919006325	Thioredoxin; Region: Thioredoxin_4; cl17273
1074919006326	FemAB family; Region: FemAB; pfam02388
1074919006327	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1074919006328	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1074919006329	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1074919006330	Walker A/P-loop; other site
1074919006331	ATP binding site [chemical binding]; other site
1074919006332	Q-loop/lid; other site
1074919006333	ABC transporter signature motif; other site
1074919006334	Walker B; other site
1074919006335	D-loop; other site
1074919006336	H-loop/switch region; other site
1074919006337	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006338	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1074919006339	dimer interface [polypeptide binding]; other site
1074919006340	conserved gate region; other site
1074919006341	putative PBP binding loops; other site
1074919006342	ABC-ATPase subunit interface; other site
1074919006343	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1074919006344	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1074919006345	substrate binding pocket [chemical binding]; other site
1074919006346	membrane-bound complex binding site; other site
1074919006347	hinge residues; other site
1074919006348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006349	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919006350	putative substrate translocation pore; other site
1074919006351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006352	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074919006353	catalytic core [active]
1074919006354	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074919006355	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1074919006356	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1074919006357	B domain; Region: B; pfam02216
1074919006358	B domain; Region: B; pfam02216
1074919006359	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
1074919006360	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1074919006361	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1074919006362	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
1074919006363	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
1074919006364	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1074919006365	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919006366	catalytic residue [active]
1074919006367	biotin synthase; Validated; Region: PRK06256
1074919006368	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919006369	FeS/SAM binding site; other site
1074919006370	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1074919006371	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919006372	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1074919006373	inhibitor-cofactor binding pocket; inhibition site
1074919006374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919006375	catalytic residue [active]
1074919006376	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1074919006377	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1074919006378	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1074919006379	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919006380	Walker A/P-loop; other site
1074919006381	ATP binding site [chemical binding]; other site
1074919006382	Q-loop/lid; other site
1074919006383	ABC transporter signature motif; other site
1074919006384	Walker B; other site
1074919006385	D-loop; other site
1074919006386	H-loop/switch region; other site
1074919006387	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1074919006388	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919006389	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006390	Walker A/P-loop; other site
1074919006391	ATP binding site [chemical binding]; other site
1074919006392	Q-loop/lid; other site
1074919006393	ABC transporter signature motif; other site
1074919006394	Walker B; other site
1074919006395	D-loop; other site
1074919006396	H-loop/switch region; other site
1074919006397	glycerate kinase; Region: TIGR00045
1074919006398	hypothetical protein; Provisional; Region: PRK11281
1074919006399	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1074919006400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006401	putative substrate translocation pore; other site
1074919006402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1074919006403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990
1074919006404	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1074919006405	putative phosphoesterase; Region: acc_ester; TIGR03729
1074919006406	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1074919006407	Spore germination protein; Region: Spore_permease; cl17796
1074919006408	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1074919006409	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1074919006410	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1074919006411	Beta-lactamase; Region: Beta-lactamase; pfam00144
1074919006412	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1074919006413	extended (e) SDRs; Region: SDR_e; cd08946
1074919006414	NAD(P) binding site [chemical binding]; other site
1074919006415	active site
1074919006416	substrate binding site [chemical binding]; other site
1074919006417	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1074919006418	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1074919006419	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1074919006420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006421	putative substrate translocation pore; other site
1074919006422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006424	dimer interface [polypeptide binding]; other site
1074919006425	conserved gate region; other site
1074919006426	ABC-ATPase subunit interface; other site
1074919006427	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1074919006428	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1074919006429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006430	dimer interface [polypeptide binding]; other site
1074919006431	conserved gate region; other site
1074919006432	putative PBP binding loops; other site
1074919006433	ABC-ATPase subunit interface; other site
1074919006434	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1074919006435	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1074919006436	Walker A/P-loop; other site
1074919006437	ATP binding site [chemical binding]; other site
1074919006438	Q-loop/lid; other site
1074919006439	ABC transporter signature motif; other site
1074919006440	Walker B; other site
1074919006441	D-loop; other site
1074919006442	H-loop/switch region; other site
1074919006443	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1074919006444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1074919006445	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1074919006446	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1074919006447	amino acid transporter; Region: 2A0306; TIGR00909
1074919006448	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1074919006449	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1074919006450	substrate binding pocket [chemical binding]; other site
1074919006451	catalytic triad [active]
1074919006452	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1074919006453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006454	putative substrate translocation pore; other site
1074919006455	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1074919006456	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1074919006457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006458	Walker A/P-loop; other site
1074919006459	ATP binding site [chemical binding]; other site
1074919006460	Q-loop/lid; other site
1074919006461	ABC transporter signature motif; other site
1074919006462	Walker B; other site
1074919006463	D-loop; other site
1074919006464	H-loop/switch region; other site
1074919006465	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1074919006466	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1074919006467	oligomer interface [polypeptide binding]; other site
1074919006468	active site
1074919006469	metal binding site [ion binding]; metal-binding site
1074919006470	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
1074919006471	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1074919006472	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1074919006473	active site
1074919006474	FMN binding site [chemical binding]; other site
1074919006475	substrate binding site [chemical binding]; other site
1074919006476	3Fe-4S cluster binding site [ion binding]; other site
1074919006477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006478	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919006479	putative substrate translocation pore; other site
1074919006480	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1074919006481	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919006482	Walker A/P-loop; other site
1074919006483	ATP binding site [chemical binding]; other site
1074919006484	Q-loop/lid; other site
1074919006485	ABC transporter signature motif; other site
1074919006486	Walker B; other site
1074919006487	D-loop; other site
1074919006488	H-loop/switch region; other site
1074919006489	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919006490	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1074919006491	Walker A/P-loop; other site
1074919006492	ATP binding site [chemical binding]; other site
1074919006493	Q-loop/lid; other site
1074919006494	ABC transporter signature motif; other site
1074919006495	Walker B; other site
1074919006496	D-loop; other site
1074919006497	H-loop/switch region; other site
1074919006498	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074919006499	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1074919006500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006501	dimer interface [polypeptide binding]; other site
1074919006502	conserved gate region; other site
1074919006503	putative PBP binding loops; other site
1074919006504	ABC-ATPase subunit interface; other site
1074919006505	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919006506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006507	dimer interface [polypeptide binding]; other site
1074919006508	conserved gate region; other site
1074919006509	putative PBP binding loops; other site
1074919006510	ABC-ATPase subunit interface; other site
1074919006511	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1074919006512	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074919006513	substrate binding site [chemical binding]; other site
1074919006514	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
1074919006515	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
1074919006516	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1074919006517	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1074919006518	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1074919006519	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1074919006520	short chain dehydrogenase; Validated; Region: PRK08589
1074919006521	classical (c) SDRs; Region: SDR_c; cd05233
1074919006522	NAD(P) binding site [chemical binding]; other site
1074919006523	active site
1074919006524	AbgT putative transporter family; Region: ABG_transport; pfam03806
1074919006525	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1074919006526	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1074919006527	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1074919006528	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1074919006529	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1074919006530	classical (c) SDRs; Region: SDR_c; cd05233
1074919006531	NAD(P) binding site [chemical binding]; other site
1074919006532	active site
1074919006533	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919006534	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919006535	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919006536	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919006537	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1074919006538	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
1074919006539	PLD-like domain; Region: PLDc_2; pfam13091
1074919006540	putative homodimer interface [polypeptide binding]; other site
1074919006541	putative active site [active]
1074919006542	catalytic site [active]
1074919006543	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1074919006544	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919006545	ATP binding site [chemical binding]; other site
1074919006546	putative Mg++ binding site [ion binding]; other site
1074919006547	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919006548	nucleotide binding region [chemical binding]; other site
1074919006549	ATP-binding site [chemical binding]; other site
1074919006550	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1074919006551	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1074919006552	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1074919006553	active site
1074919006554	substrate binding site [chemical binding]; other site
1074919006555	metal binding site [ion binding]; metal-binding site
1074919006556	H+ Antiporter protein; Region: 2A0121; TIGR00900
1074919006557	G5 domain; Region: G5; pfam07501
1074919006558	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1074919006559	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919006560	legume lectins; Region: lectin_L-type; cl14058
1074919006561	homotetramer interaction site [polypeptide binding]; other site
1074919006562	carbohydrate binding site [chemical binding]; other site
1074919006563	metal binding site [ion binding]; metal-binding site
1074919006564	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919006565	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919006566	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919006567	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1074919006568	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1074919006569	active site
1074919006570	tetramer interface; other site
1074919006571	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919006572	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919006573	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1074919006574	GntP family permease; Region: GntP_permease; pfam02447
1074919006575	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1074919006576	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1074919006577	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1074919006578	N- and C-terminal domain interface [polypeptide binding]; other site
1074919006579	active site
1074919006580	catalytic site [active]
1074919006581	metal binding site [ion binding]; metal-binding site
1074919006582	carbohydrate binding site [chemical binding]; other site
1074919006583	ATP binding site [chemical binding]; other site
1074919006584	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1074919006585	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919006586	DNA-binding site [nucleotide binding]; DNA binding site
1074919006587	FCD domain; Region: FCD; pfam07729
1074919006588	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1074919006589	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1074919006590	DNA binding residues [nucleotide binding]
1074919006591	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1074919006592	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1074919006593	synthetase active site [active]
1074919006594	NTP binding site [chemical binding]; other site
1074919006595	metal binding site [ion binding]; metal-binding site
1074919006596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1074919006597	Predicted membrane protein [Function unknown]; Region: COG1289
1074919006598	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1074919006599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006600	D-galactonate transporter; Region: 2A0114; TIGR00893
1074919006601	putative substrate translocation pore; other site
1074919006602	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1074919006603	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1074919006604	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1074919006605	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006606	Walker A/P-loop; other site
1074919006607	ATP binding site [chemical binding]; other site
1074919006608	Q-loop/lid; other site
1074919006609	ABC transporter signature motif; other site
1074919006610	Walker B; other site
1074919006611	D-loop; other site
1074919006612	H-loop/switch region; other site
1074919006613	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1074919006614	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1074919006615	Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855
1074919006616	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1074919006617	Predicted esterase [General function prediction only]; Region: COG0400
1074919006618	putative hydrolase; Provisional; Region: PRK11460
1074919006619	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1074919006620	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1074919006621	Zn binding site [ion binding]; other site
1074919006622	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1074919006623	Zn binding site [ion binding]; other site
1074919006624	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1074919006625	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1074919006626	putative metal binding site [ion binding]; other site
1074919006627	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1074919006628	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1074919006629	dimer interface [polypeptide binding]; other site
1074919006630	FMN binding site [chemical binding]; other site
1074919006631	D-lactate dehydrogenase; Provisional; Region: PRK12480
1074919006632	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1074919006633	homodimer interface [polypeptide binding]; other site
1074919006634	ligand binding site [chemical binding]; other site
1074919006635	NAD binding site [chemical binding]; other site
1074919006636	catalytic site [active]
1074919006637	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1074919006638	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919006639	active site
1074919006640	motif I; other site
1074919006641	motif II; other site
1074919006642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006643	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919006644	Walker A/P-loop; other site
1074919006645	ATP binding site [chemical binding]; other site
1074919006646	Q-loop/lid; other site
1074919006647	ABC transporter signature motif; other site
1074919006648	Walker B; other site
1074919006649	D-loop; other site
1074919006650	H-loop/switch region; other site
1074919006651	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
1074919006652	active site
1074919006653	catalytic site [active]
1074919006654	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1074919006655	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006656	Coenzyme A binding pocket [chemical binding]; other site
1074919006657	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919006658	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1074919006659	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1074919006660	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1074919006661	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1074919006662	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1074919006663	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1074919006664	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1074919006665	EamA-like transporter family; Region: EamA; pfam00892
1074919006666	EamA-like transporter family; Region: EamA; pfam00892
1074919006667	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1074919006668	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1074919006669	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919006670	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1074919006671	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919006672	active site turn [active]
1074919006673	phosphorylation site [posttranslational modification]
1074919006674	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1074919006675	HPr interaction site; other site
1074919006676	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074919006677	active site
1074919006678	phosphorylation site [posttranslational modification]
1074919006679	pyruvate oxidase; Provisional; Region: PRK08611
1074919006680	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1074919006681	PYR/PP interface [polypeptide binding]; other site
1074919006682	tetramer interface [polypeptide binding]; other site
1074919006683	dimer interface [polypeptide binding]; other site
1074919006684	TPP binding site [chemical binding]; other site
1074919006685	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074919006686	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1074919006687	TPP-binding site [chemical binding]; other site
1074919006688	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1074919006689	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919006690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919006691	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1074919006692	putative dimerization interface [polypeptide binding]; other site
1074919006693	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1074919006694	homodimer interface [polypeptide binding]; other site
1074919006695	catalytic residues [active]
1074919006696	NAD binding site [chemical binding]; other site
1074919006697	substrate binding pocket [chemical binding]; other site
1074919006698	flexible flap; other site
1074919006699	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1074919006700	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1074919006701	dimer interface [polypeptide binding]; other site
1074919006702	active site
1074919006703	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1074919006704	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1074919006705	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1074919006706	DNA binding site [nucleotide binding]
1074919006707	active site
1074919006708	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919006709	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1074919006710	Walker A motif; other site
1074919006711	ATP binding site [chemical binding]; other site
1074919006712	Walker B motif; other site
1074919006713	arginine finger; other site
1074919006714	UvrB/uvrC motif; Region: UVR; pfam02151
1074919006715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919006716	Walker A motif; other site
1074919006717	ATP binding site [chemical binding]; other site
1074919006718	Walker B motif; other site
1074919006719	arginine finger; other site
1074919006720	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1074919006721	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1074919006722	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1074919006723	G1 box; other site
1074919006724	GTP/Mg2+ binding site [chemical binding]; other site
1074919006725	Switch I region; other site
1074919006726	G2 box; other site
1074919006727	G3 box; other site
1074919006728	Switch II region; other site
1074919006729	G4 box; other site
1074919006730	G5 box; other site
1074919006731	Nucleoside recognition; Region: Gate; pfam07670
1074919006732	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1074919006733	Nucleoside recognition; Region: Gate; pfam07670
1074919006734	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1074919006735	methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080
1074919006736	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919006737	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919006738	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1074919006739	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1074919006740	Glutamate binding site [chemical binding]; other site
1074919006741	homodimer interface [polypeptide binding]; other site
1074919006742	NAD binding site [chemical binding]; other site
1074919006743	catalytic residues [active]
1074919006744	maltose O-acetyltransferase; Provisional; Region: PRK10092
1074919006745	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1074919006746	active site
1074919006747	substrate binding site [chemical binding]; other site
1074919006748	trimer interface [polypeptide binding]; other site
1074919006749	CoA binding site [chemical binding]; other site
1074919006750	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1074919006751	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1074919006752	metal-binding site [ion binding]
1074919006753	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1074919006754	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1074919006755	metal-binding site [ion binding]
1074919006756	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1074919006757	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1074919006758	D-lactate dehydrogenase; Validated; Region: PRK08605
1074919006759	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1074919006760	homodimer interface [polypeptide binding]; other site
1074919006761	ligand binding site [chemical binding]; other site
1074919006762	NAD binding site [chemical binding]; other site
1074919006763	catalytic site [active]
1074919006764	transaminase; Reviewed; Region: PRK08068
1074919006765	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919006766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919006767	homodimer interface [polypeptide binding]; other site
1074919006768	catalytic residue [active]
1074919006769	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1074919006770	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074919006771	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1074919006772	active site lid residues [active]
1074919006773	substrate binding pocket [chemical binding]; other site
1074919006774	catalytic residues [active]
1074919006775	substrate-Mg2+ binding site; other site
1074919006776	aspartate-rich region 1; other site
1074919006777	aspartate-rich region 2; other site
1074919006778	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1074919006779	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1074919006780	active site
1074919006781	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1074919006782	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074919006783	Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237
1074919006784	Surface antigen [General function prediction only]; Region: COG3942
1074919006785	CHAP domain; Region: CHAP; pfam05257
1074919006786	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1074919006787	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1074919006788	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1074919006789	catalytic triad [active]
1074919006790	catalytic triad [active]
1074919006791	oxyanion hole [active]
1074919006792	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006793	Coenzyme A binding pocket [chemical binding]; other site
1074919006794	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1074919006795	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1074919006796	catalytic residue [active]
1074919006797	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1074919006798	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1074919006799	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919006800	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919006801	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1074919006802	NmrA-like family; Region: NmrA; pfam05368
1074919006803	NADP binding site [chemical binding]; other site
1074919006804	active site
1074919006805	regulatory binding site [polypeptide binding]; other site
1074919006806	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919006807	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919006808	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919006809	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
1074919006810	NAD(P) binding site [chemical binding]; other site
1074919006811	active site
1074919006812	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1074919006813	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1074919006814	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1074919006815	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1074919006816	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1074919006817	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1074919006818	Nucleoside recognition; Region: Gate; pfam07670
1074919006819	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1074919006820	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1074919006821	Phosphotransferase enzyme family; Region: APH; pfam01636
1074919006822	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1074919006823	active site
1074919006824	ATP binding site [chemical binding]; other site
1074919006825	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1074919006826	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1074919006827	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1074919006828	quinone interaction residues [chemical binding]; other site
1074919006829	active site
1074919006830	catalytic residues [active]
1074919006831	FMN binding site [chemical binding]; other site
1074919006832	substrate binding site [chemical binding]; other site
1074919006833	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1074919006834	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919006835	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919006836	Predicted acyl esterases [General function prediction only]; Region: COG2936
1074919006837	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1074919006838	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919006839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919006840	S-adenosylmethionine binding site [chemical binding]; other site
1074919006841	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1074919006842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919006843	S-adenosylmethionine binding site [chemical binding]; other site
1074919006844	aminoglycoside resistance protein; Provisional; Region: PRK13746
1074919006845	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1074919006846	active site
1074919006847	NTP binding site [chemical binding]; other site
1074919006848	metal binding triad [ion binding]; metal-binding site
1074919006849	antibiotic binding site [chemical binding]; other site
1074919006850	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1074919006851	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919006852	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919006853	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919006854	active site
1074919006855	DNA binding site [nucleotide binding]
1074919006856	Int/Topo IB signature motif; other site
1074919006857	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919006858	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1074919006859	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1074919006860	Int/Topo IB signature motif; other site
1074919006861	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919006862	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1074919006863	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1074919006864	active site
1074919006865	ATP-binding site [chemical binding]; other site
1074919006866	pantoate-binding site; other site
1074919006867	HXXH motif; other site
1074919006868	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1074919006869	active site
1074919006870	oligomerization interface [polypeptide binding]; other site
1074919006871	metal binding site [ion binding]; metal-binding site
1074919006872	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1074919006873	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1074919006874	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1074919006875	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1074919006876	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1074919006877	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1074919006878	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074919006879	NAD binding site [chemical binding]; other site
1074919006880	dimer interface [polypeptide binding]; other site
1074919006881	substrate binding site [chemical binding]; other site
1074919006882	amino acid transporter; Region: 2A0306; TIGR00909
1074919006883	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1074919006884	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
1074919006885	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919006886	inhibitor-cofactor binding pocket; inhibition site
1074919006887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919006888	catalytic residue [active]
1074919006889	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
1074919006890	catalytic residue [active]
1074919006891	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
1074919006892	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1074919006893	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1074919006894	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074919006895	acyl-activating enzyme (AAE) consensus motif; other site
1074919006896	AMP binding site [chemical binding]; other site
1074919006897	active site
1074919006898	CoA binding site [chemical binding]; other site
1074919006899	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1074919006900	choline dehydrogenase; Validated; Region: PRK02106
1074919006901	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1074919006902	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1074919006903	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1074919006904	tetramerization interface [polypeptide binding]; other site
1074919006905	NAD(P) binding site [chemical binding]; other site
1074919006906	catalytic residues [active]
1074919006907	Predicted transcriptional regulators [Transcription]; Region: COG1510
1074919006908	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1074919006909	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1074919006910	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1074919006911	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
1074919006912	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1074919006913	effector binding site; other site
1074919006914	active site
1074919006915	Zn binding site [ion binding]; other site
1074919006916	glycine loop; other site
1074919006917	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1074919006918	Citrate transporter; Region: CitMHS; pfam03600
1074919006919	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
1074919006920	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1074919006921	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1074919006922	Flavodoxin; Region: Flavodoxin_1; pfam00258
1074919006923	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1074919006924	FAD binding pocket [chemical binding]; other site
1074919006925	FAD binding motif [chemical binding]; other site
1074919006926	catalytic residues [active]
1074919006927	NAD binding pocket [chemical binding]; other site
1074919006928	phosphate binding motif [ion binding]; other site
1074919006929	beta-alpha-beta structure motif; other site
1074919006930	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1074919006931	catalytic residues [active]
1074919006932	dimer interface [polypeptide binding]; other site
1074919006933	FtsX-like permease family; Region: FtsX; pfam02687
1074919006934	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919006935	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919006936	Walker A/P-loop; other site
1074919006937	ATP binding site [chemical binding]; other site
1074919006938	Q-loop/lid; other site
1074919006939	ABC transporter signature motif; other site
1074919006940	Walker B; other site
1074919006941	D-loop; other site
1074919006942	H-loop/switch region; other site
1074919006943	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919006944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919006945	ATP binding site [chemical binding]; other site
1074919006946	Mg2+ binding site [ion binding]; other site
1074919006947	G-X-G motif; other site
1074919006948	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919006949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919006950	active site
1074919006951	phosphorylation site [posttranslational modification]
1074919006952	intermolecular recognition site; other site
1074919006953	dimerization interface [polypeptide binding]; other site
1074919006954	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919006955	DNA binding site [nucleotide binding]
1074919006956	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1074919006957	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1074919006958	dimer interface [polypeptide binding]; other site
1074919006959	active site
1074919006960	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1074919006961	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1074919006962	MarR family; Region: MarR_2; pfam12802
1074919006963	Predicted esterase [General function prediction only]; Region: COG0627
1074919006964	S-formylglutathione hydrolase; Region: PLN02442
1074919006965	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919006966	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919006967	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1074919006968	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1074919006969	ligand binding site [chemical binding]; other site
1074919006970	flexible hinge region; other site
1074919006971	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1074919006972	carbamate kinase; Reviewed; Region: PRK12686
1074919006973	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1074919006974	putative substrate binding site [chemical binding]; other site
1074919006975	nucleotide binding site [chemical binding]; other site
1074919006976	nucleotide binding site [chemical binding]; other site
1074919006977	homodimer interface [polypeptide binding]; other site
1074919006978	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1074919006979	ornithine carbamoyltransferase; Validated; Region: PRK02102
1074919006980	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1074919006981	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1074919006982	arginine deiminase; Provisional; Region: PRK01388
1074919006983	Arginine repressor [Transcription]; Region: ArgR; COG1438
1074919006984	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1074919006985	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1074919006986	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1074919006987	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1074919006988	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1074919006989	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1074919006990	active site
1074919006991	Zn binding site [ion binding]; other site
1074919006992	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919006993	HTH domain; Region: HTH_11; pfam08279
1074919006994	PRD domain; Region: PRD; pfam00874
1074919006995	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1074919006996	active site
1074919006997	P-loop; other site
1074919006998	phosphorylation site [posttranslational modification]
1074919006999	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919007000	active site
1074919007001	phosphorylation site [posttranslational modification]
1074919007002	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1074919007003	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1074919007004	active site
1074919007005	P-loop; other site
1074919007006	phosphorylation site [posttranslational modification]
1074919007007	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1074919007008	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919007009	active site
1074919007010	phosphorylation site [posttranslational modification]
1074919007011	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1074919007012	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1074919007013	Predicted membrane protein [Function unknown]; Region: COG1511
1074919007014	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1074919007015	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1074919007016	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
1074919007017	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1074919007018	CHAP domain; Region: CHAP; pfam05257
1074919007019	Isochorismatase family; Region: Isochorismatase; pfam00857
1074919007020	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1074919007021	catalytic triad [active]
1074919007022	conserved cis-peptide bond; other site
1074919007023	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1074919007024	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1074919007025	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1074919007026	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1074919007027	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
1074919007028	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1074919007029	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1074919007030	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1074919007031	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1074919007032	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1074919007033	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1074919007034	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
1074919007035	SecY translocase; Region: SecY; pfam00344
1074919007036	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1074919007037	legume lectins; Region: lectin_L-type; cd01951
1074919007038	homotetramer interaction site [polypeptide binding]; other site
1074919007039	carbohydrate binding site [chemical binding]; other site
1074919007040	metal binding site [ion binding]; metal-binding site
1074919007041	Putative Ig domain; Region: He_PIG; pfam05345
1074919007042	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1074919007043	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1074919007044	methionine sulfoxide reductase A; Provisional; Region: PRK05528
1074919007045	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1074919007046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919007047	Coenzyme A binding pocket [chemical binding]; other site
1074919007048	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1074919007049	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1074919007050	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1074919007051	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1074919007052	Chain length determinant protein; Region: Wzz; cl15801
1074919007053	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919007054	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919007055	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
1074919007056	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1074919007057	DXD motif; other site
1074919007058	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
1074919007059	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1074919007060	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1074919007061	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1074919007062	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1074919007063	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1074919007064	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1074919007065	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1074919007066	metal binding site [ion binding]; metal-binding site
1074919007067	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1074919007068	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1074919007069	glutamase interaction surface [polypeptide binding]; other site
1074919007070	substrate binding site [chemical binding]; other site
1074919007071	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1074919007072	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1074919007073	catalytic residues [active]
1074919007074	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1074919007075	putative active site [active]
1074919007076	oxyanion strand; other site
1074919007077	catalytic triad [active]
1074919007078	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1074919007079	putative active site pocket [active]
1074919007080	4-fold oligomerization interface [polypeptide binding]; other site
1074919007081	metal binding residues [ion binding]; metal-binding site
1074919007082	3-fold/trimer interface [polypeptide binding]; other site
1074919007083	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1074919007084	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919007085	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919007086	homodimer interface [polypeptide binding]; other site
1074919007087	catalytic residue [active]
1074919007088	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1074919007089	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1074919007090	NAD binding site [chemical binding]; other site
1074919007091	dimerization interface [polypeptide binding]; other site
1074919007092	product binding site; other site
1074919007093	substrate binding site [chemical binding]; other site
1074919007094	zinc binding site [ion binding]; other site
1074919007095	catalytic residues [active]
1074919007096	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
1074919007097	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1074919007098	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
1074919007099	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
1074919007100	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1074919007101	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1074919007102	putative active site [active]
1074919007103	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1074919007104	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1074919007105	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919007106	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919007107	Walker A/P-loop; other site
1074919007108	ATP binding site [chemical binding]; other site
1074919007109	Q-loop/lid; other site
1074919007110	ABC transporter signature motif; other site
1074919007111	Walker B; other site
1074919007112	D-loop; other site
1074919007113	H-loop/switch region; other site
1074919007114	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1074919007115	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919007116	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919007117	Walker A/P-loop; other site
1074919007118	ATP binding site [chemical binding]; other site
1074919007119	Q-loop/lid; other site
1074919007120	ABC transporter signature motif; other site
1074919007121	Walker B; other site
1074919007122	H-loop/switch region; other site
1074919007123	hypothetical protein; Provisional; Region: PRK13661
1074919007124	Uncharacterized conserved protein [Function unknown]; Region: COG1912
1074919007125	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1074919007126	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1074919007127	Strictosidine synthase; Region: Str_synth; pfam03088
1074919007128	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1074919007129	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1074919007130	active site residue [active]
1074919007131	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1074919007132	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1074919007133	putative substrate binding pocket [chemical binding]; other site
1074919007134	AC domain interface; other site
1074919007135	catalytic triad [active]
1074919007136	AB domain interface; other site
1074919007137	interchain disulfide; other site
1074919007138	DinB superfamily; Region: DinB_2; pfam12867
1074919007139	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1074919007140	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1074919007141	transmembrane helices; other site
1074919007142	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1074919007143	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1074919007144	hypothetical protein; Provisional; Region: PRK07758
1074919007145	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1074919007146	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1074919007147	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1074919007148	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919007149	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919007150	Walker A/P-loop; other site
1074919007151	ATP binding site [chemical binding]; other site
1074919007152	Q-loop/lid; other site
1074919007153	ABC transporter signature motif; other site
1074919007154	Walker B; other site
1074919007155	D-loop; other site
1074919007156	H-loop/switch region; other site
1074919007157	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074919007158	FtsX-like permease family; Region: FtsX; pfam02687
1074919007159	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074919007160	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919007161	non-specific DNA binding site [nucleotide binding]; other site
1074919007162	salt bridge; other site
1074919007163	sequence-specific DNA binding site [nucleotide binding]; other site
1074919007164	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1074919007165	ParB-like nuclease domain; Region: ParBc; pfam02195
1074919007166	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1074919007167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919007168	S-adenosylmethionine binding site [chemical binding]; other site
1074919007169	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1074919007170	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1074919007171	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1074919007172	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1074919007173	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1074919007174	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1074919007175	G1 box; other site
1074919007176	GTP/Mg2+ binding site [chemical binding]; other site
1074919007177	Switch I region; other site
1074919007178	G2 box; other site
1074919007179	Switch II region; other site
1074919007180	G3 box; other site
1074919007181	G4 box; other site
1074919007182	G5 box; other site
1074919007183	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1074919007184	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1074919007185	Integrase core domain; Region: rve; pfam00665
1074919007186	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1074919007187	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1074919007188	metal-binding site [ion binding]
1074919007189	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1074919007190	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1074919007191	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1074919007192	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1074919007193	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1074919007194	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1074919007195	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1074919007196	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1074919007197	catalytic residues [active]
1074919007198	catalytic nucleophile [active]
1074919007199	Presynaptic Site I dimer interface [polypeptide binding]; other site
1074919007200	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1074919007201	Synaptic Flat tetramer interface [polypeptide binding]; other site
1074919007202	Synaptic Site I dimer interface [polypeptide binding]; other site
1074919007203	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1074919007204	DNA-binding interface [nucleotide binding]; DNA binding site
1074919007205	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1074919007206	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1074919007207	catalytic residues [active]
1074919007208	catalytic nucleophile [active]
1074919007209	Presynaptic Site I dimer interface [polypeptide binding]; other site
1074919007210	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1074919007211	Synaptic Flat tetramer interface [polypeptide binding]; other site
1074919007212	Synaptic Site I dimer interface [polypeptide binding]; other site
1074919007213	DNA binding site [nucleotide binding]
1074919007214	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
1074919007215	DNA-binding interface [nucleotide binding]; DNA binding site
1074919007216	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919007217	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919007218	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1074919007219	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919007220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919007221	putative substrate translocation pore; other site
1074919007222	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
1074919007223	Replication protein; Region: Rep_1; pfam01446
1074919007224	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1074919007225	Integrase core domain; Region: rve; pfam00665
1074919007226	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1074919007227	Integrase core domain; Region: rve; pfam00665
1074919007228	alkylmercury lyase; Provisional; Region: PRK13239
1074919007229	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
1074919007230	Alkylmercury lyase; Region: MerB; pfam03243
1074919007231	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1074919007232	metal-binding site [ion binding]
1074919007233	mercuric reductase; Region: MerA; TIGR02053
1074919007234	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919007235	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074919007236	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1074919007237	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1074919007238	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1074919007239	catalytic residues [active]
1074919007240	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1074919007241	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852