-- dump date 20140620_075120 -- class Genbank::misc_feature -- table misc_feature_note -- id note 523796000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 523796000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 523796000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796000004 Walker A motif; other site 523796000005 ATP binding site [chemical binding]; other site 523796000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 523796000007 Walker B motif; other site 523796000008 arginine finger; other site 523796000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 523796000010 DnaA box-binding interface [nucleotide binding]; other site 523796000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 523796000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 523796000013 putative DNA binding surface [nucleotide binding]; other site 523796000014 dimer interface [polypeptide binding]; other site 523796000015 beta-clamp/clamp loader binding surface; other site 523796000016 beta-clamp/translesion DNA polymerase binding surface; other site 523796000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 523796000018 recF protein; Region: recf; TIGR00611 523796000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 523796000020 Walker A/P-loop; other site 523796000021 ATP binding site [chemical binding]; other site 523796000022 Q-loop/lid; other site 523796000023 ABC transporter signature motif; other site 523796000024 Walker B; other site 523796000025 D-loop; other site 523796000026 H-loop/switch region; other site 523796000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 523796000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796000029 ATP binding site [chemical binding]; other site 523796000030 Mg2+ binding site [ion binding]; other site 523796000031 G-X-G motif; other site 523796000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 523796000033 anchoring element; other site 523796000034 dimer interface [polypeptide binding]; other site 523796000035 ATP binding site [chemical binding]; other site 523796000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 523796000037 active site 523796000038 putative metal-binding site [ion binding]; other site 523796000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 523796000040 DNA gyrase subunit A; Validated; Region: PRK05560 523796000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 523796000042 CAP-like domain; other site 523796000043 active site 523796000044 primary dimer interface [polypeptide binding]; other site 523796000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523796000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523796000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523796000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523796000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523796000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523796000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 523796000052 putative substrate binding site [chemical binding]; other site 523796000053 putative ATP binding site [chemical binding]; other site 523796000054 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 523796000055 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 523796000056 active sites [active] 523796000057 tetramer interface [polypeptide binding]; other site 523796000058 seryl-tRNA synthetase; Provisional; Region: PRK05431 523796000059 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 523796000060 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 523796000061 dimer interface [polypeptide binding]; other site 523796000062 active site 523796000063 motif 1; other site 523796000064 motif 2; other site 523796000065 motif 3; other site 523796000066 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 523796000067 Predicted membrane protein [Function unknown]; Region: COG4392 523796000068 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 523796000069 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 523796000070 Predicted membrane protein [Function unknown]; Region: COG4241 523796000071 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 523796000072 Protein of unknown function (DUF996); Region: DUF996; cl00970 523796000073 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 523796000074 DHH family; Region: DHH; pfam01368 523796000075 DHHA1 domain; Region: DHHA1; pfam02272 523796000076 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 523796000077 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 523796000078 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 523796000079 replicative DNA helicase; Region: DnaB; TIGR00665 523796000080 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 523796000081 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 523796000082 Walker A motif; other site 523796000083 ATP binding site [chemical binding]; other site 523796000084 Walker B motif; other site 523796000085 DNA binding loops [nucleotide binding] 523796000086 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 523796000087 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 523796000088 GDP-binding site [chemical binding]; other site 523796000089 ACT binding site; other site 523796000090 IMP binding site; other site 523796000091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523796000092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796000093 active site 523796000094 phosphorylation site [posttranslational modification] 523796000095 intermolecular recognition site; other site 523796000096 dimerization interface [polypeptide binding]; other site 523796000097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523796000098 DNA binding site [nucleotide binding] 523796000099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 523796000100 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523796000101 dimerization interface [polypeptide binding]; other site 523796000102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523796000103 putative active site [active] 523796000104 heme pocket [chemical binding]; other site 523796000105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523796000106 dimer interface [polypeptide binding]; other site 523796000107 phosphorylation site [posttranslational modification] 523796000108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796000109 ATP binding site [chemical binding]; other site 523796000110 Mg2+ binding site [ion binding]; other site 523796000111 G-X-G motif; other site 523796000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 523796000113 YycH protein; Region: YycH; pfam07435 523796000114 YycH protein; Region: YycI; cl02015 523796000115 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 523796000116 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 523796000117 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 523796000118 putative active site [active] 523796000119 putative metal binding site [ion binding]; other site 523796000120 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 523796000121 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 523796000122 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 523796000123 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 523796000124 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 523796000125 GIY-YIG motif/motif A; other site 523796000126 putative active site [active] 523796000127 putative metal binding site [ion binding]; other site 523796000128 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 523796000129 active site 523796000130 DNA binding site [nucleotide binding] 523796000131 catalytic site [active] 523796000132 Phage associated DNA primase [General function prediction only]; Region: COG3378 523796000133 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 523796000134 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 523796000135 catalytic residues [active] 523796000136 catalytic nucleophile [active] 523796000137 Recombinase; Region: Recombinase; pfam07508 523796000138 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 523796000139 FlxA-like protein; Region: FlxA; pfam14282 523796000140 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 523796000141 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 523796000142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 523796000143 Integrase core domain; Region: rve; pfam00665 523796000144 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 523796000145 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 523796000146 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 523796000147 putative active site [active] 523796000148 catalytic site [active] 523796000149 putative metal binding site [ion binding]; other site 523796000150 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 523796000151 putative active site [active] 523796000152 putative catalytic site [active] 523796000153 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 523796000154 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 523796000155 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 523796000156 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 523796000157 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 523796000158 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 523796000159 dimer interface [polypeptide binding]; other site 523796000160 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523796000161 Predicted transcriptional regulator [Transcription]; Region: COG2378 523796000162 HTH domain; Region: HTH_11; pfam08279 523796000163 WYL domain; Region: WYL; pfam13280 523796000164 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 523796000165 active site 523796000166 DNA binding site [nucleotide binding] 523796000167 catalytic site [active] 523796000168 Phage associated DNA primase [General function prediction only]; Region: COG3378 523796000169 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 523796000170 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 523796000171 catalytic residues [active] 523796000172 catalytic nucleophile [active] 523796000173 Recombinase; Region: Recombinase; pfam07508 523796000174 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 523796000175 FlxA-like protein; Region: FlxA; pfam14282 523796000176 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 523796000177 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 523796000178 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 523796000179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 523796000180 Integrase core domain; Region: rve; pfam00665 523796000181 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 523796000182 active site 523796000183 metal binding site [ion binding]; metal-binding site 523796000184 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 523796000185 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 523796000186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523796000187 Soluble P-type ATPase [General function prediction only]; Region: COG4087 523796000188 Rhodanese Homology Domain; Region: RHOD; smart00450 523796000189 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523796000190 active site residue [active] 523796000191 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 523796000192 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523796000193 active site residue [active] 523796000194 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 523796000195 CPxP motif; other site 523796000196 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 523796000197 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 523796000198 putative homodimer interface [polypeptide binding]; other site 523796000199 putative homotetramer interface [polypeptide binding]; other site 523796000200 putative metal binding site [ion binding]; other site 523796000201 putative homodimer-homodimer interface [polypeptide binding]; other site 523796000202 putative allosteric switch controlling residues; other site 523796000203 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 523796000204 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 523796000205 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 523796000206 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 523796000207 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 523796000208 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 523796000209 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 523796000210 Integrase core domain; Region: rve; pfam00665 523796000211 Class I aldolases; Region: Aldolase_Class_I; cl17187 523796000212 Winged helix-turn helix; Region: HTH_29; pfam13551 523796000213 Homeodomain-like domain; Region: HTH_32; pfam13565 523796000214 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 523796000215 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 523796000216 Surface antigen [General function prediction only]; Region: COG3942 523796000217 CHAP domain; Region: CHAP; pfam05257 523796000218 Acyltransferase family; Region: Acyl_transf_3; cl19154 523796000219 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523796000220 AAA-like domain; Region: AAA_10; pfam12846 523796000221 TcpE family; Region: TcpE; pfam12648 523796000222 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 523796000223 Replication initiation factor; Region: Rep_trans; pfam02486 523796000224 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 523796000225 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 523796000226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796000227 AAA domain; Region: AAA_13; pfam13166 523796000228 Walker A/P-loop; other site 523796000229 ATP binding site [chemical binding]; other site 523796000230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 523796000231 Integrase core domain; Region: rve; pfam00665 523796000232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796000233 Walker A motif; other site 523796000234 ATP binding site [chemical binding]; other site 523796000235 Walker B motif; other site 523796000236 proteasome-activating nucleotidase; Provisional; Region: PRK03992 523796000237 Integrase core domain; Region: rve; pfam00665 523796000238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 523796000239 Transposase; Region: DDE_Tnp_ISL3; pfam01610 523796000240 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 523796000241 active site 523796000242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796000243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796000244 putative substrate translocation pore; other site 523796000245 N-acetyltransferase; Region: Acetyltransf_2; cl00949 523796000246 N-acetyltransferase; Region: Acetyltransf_2; cl00949 523796000247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523796000248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523796000249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796000250 Coenzyme A binding pocket [chemical binding]; other site 523796000251 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 523796000252 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 523796000253 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 523796000254 FMN binding site [chemical binding]; other site 523796000255 active site 523796000256 catalytic residues [active] 523796000257 substrate binding site [chemical binding]; other site 523796000258 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 523796000259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796000260 H+ Antiporter protein; Region: 2A0121; TIGR00900 523796000261 putative substrate translocation pore; other site 523796000262 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 523796000263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523796000264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523796000265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 523796000266 dimerization interface [polypeptide binding]; other site 523796000267 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523796000268 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 523796000269 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 523796000270 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 523796000271 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523796000272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796000273 S-adenosylmethionine binding site [chemical binding]; other site 523796000274 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 523796000275 active site 523796000276 catalytic site [active] 523796000277 putative metal binding site [ion binding]; other site 523796000278 Protein of unknown function, DUF576; Region: DUF576; pfam04507 523796000279 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 523796000280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523796000281 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 523796000282 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 523796000283 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 523796000284 metal binding site [ion binding]; metal-binding site 523796000285 dimer interface [polypeptide binding]; other site 523796000286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796000287 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796000288 putative substrate translocation pore; other site 523796000289 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 523796000290 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 523796000291 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 523796000292 PhoU domain; Region: PhoU; pfam01895 523796000293 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 523796000294 myosin-cross-reactive antigen; Provisional; Region: PRK13977 523796000295 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 523796000296 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 523796000297 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 523796000298 B domain; Region: B; pfam02216 523796000299 B domain; Region: B; pfam02216 523796000300 B domain; Region: B; pfam02216 523796000301 B domain; Region: B; pfam02216 523796000302 B domain; Region: B; pfam02216 523796000303 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523796000304 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 523796000305 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796000306 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 523796000307 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796000308 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796000309 ABC-ATPase subunit interface; other site 523796000310 dimer interface [polypeptide binding]; other site 523796000311 putative PBP binding regions; other site 523796000312 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796000313 ABC-ATPase subunit interface; other site 523796000314 dimer interface [polypeptide binding]; other site 523796000315 putative PBP binding regions; other site 523796000316 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 523796000317 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 523796000318 siderophore binding site; other site 523796000319 cysteine synthase; Region: PLN02565 523796000320 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 523796000321 dimer interface [polypeptide binding]; other site 523796000322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796000323 catalytic residue [active] 523796000324 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 523796000325 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 523796000326 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 523796000327 IucA / IucC family; Region: IucA_IucC; pfam04183 523796000328 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 523796000329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796000330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796000331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796000332 putative substrate translocation pore; other site 523796000333 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 523796000334 IucA / IucC family; Region: IucA_IucC; pfam04183 523796000335 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 523796000336 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 523796000337 IucA / IucC family; Region: IucA_IucC; pfam04183 523796000338 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 523796000339 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 523796000340 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 523796000341 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 523796000342 dimer interface [polypeptide binding]; other site 523796000343 active site 523796000344 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523796000345 catalytic residues [active] 523796000346 substrate binding site [chemical binding]; other site 523796000347 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 523796000348 ParB-like nuclease domain; Region: ParBc; pfam02195 523796000349 acetoin reductase; Validated; Region: PRK08643 523796000350 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 523796000351 NAD binding site [chemical binding]; other site 523796000352 homotetramer interface [polypeptide binding]; other site 523796000353 homodimer interface [polypeptide binding]; other site 523796000354 active site 523796000355 substrate binding site [chemical binding]; other site 523796000356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523796000357 NAD(P) binding site [chemical binding]; other site 523796000358 active site 523796000359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523796000360 Bacterial sugar transferase; Region: Bac_transf; cl00939 523796000361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 523796000362 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 523796000363 putative ADP-binding pocket [chemical binding]; other site 523796000364 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 523796000365 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 523796000366 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 523796000367 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 523796000368 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 523796000369 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 523796000370 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 523796000371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523796000372 DNA-binding site [nucleotide binding]; DNA binding site 523796000373 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 523796000374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796000375 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 523796000376 intersubunit interface [polypeptide binding]; other site 523796000377 active site 523796000378 catalytic residue [active] 523796000379 phosphopentomutase; Region: deoB; TIGR01696 523796000380 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 523796000381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796000382 dimer interface [polypeptide binding]; other site 523796000383 conserved gate region; other site 523796000384 putative PBP binding loops; other site 523796000385 ABC-ATPase subunit interface; other site 523796000386 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 523796000387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796000388 dimer interface [polypeptide binding]; other site 523796000389 conserved gate region; other site 523796000390 putative PBP binding loops; other site 523796000391 ABC-ATPase subunit interface; other site 523796000392 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 523796000393 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 523796000394 Walker A/P-loop; other site 523796000395 ATP binding site [chemical binding]; other site 523796000396 Q-loop/lid; other site 523796000397 ABC transporter signature motif; other site 523796000398 Walker B; other site 523796000399 D-loop; other site 523796000400 H-loop/switch region; other site 523796000401 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 523796000402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 523796000403 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 523796000404 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 523796000405 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 523796000406 active site 523796000407 metal binding site [ion binding]; metal-binding site 523796000408 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 523796000409 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 523796000410 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523796000411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796000412 non-specific DNA binding site [nucleotide binding]; other site 523796000413 salt bridge; other site 523796000414 sequence-specific DNA binding site [nucleotide binding]; other site 523796000415 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 523796000416 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 523796000417 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 523796000418 putative catalytic cysteine [active] 523796000419 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 523796000420 putative active site [active] 523796000421 metal binding site [ion binding]; metal-binding site 523796000422 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 523796000423 Chain length determinant protein; Region: Wzz; pfam02706 523796000424 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 523796000425 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 523796000426 AAA domain; Region: AAA_31; pfam13614 523796000427 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 523796000428 PHP domain; Region: PHP; pfam02811 523796000429 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 523796000430 CoA binding domain; Region: CoA_binding; cl17356 523796000431 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 523796000432 NAD(P) binding site [chemical binding]; other site 523796000433 homodimer interface [polypeptide binding]; other site 523796000434 substrate binding site [chemical binding]; other site 523796000435 active site 523796000436 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 523796000437 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 523796000438 NAD(P) binding site [chemical binding]; other site 523796000439 homodimer interface [polypeptide binding]; other site 523796000440 substrate binding site [chemical binding]; other site 523796000441 active site 523796000442 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 523796000443 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 523796000444 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 523796000445 putative NAD(P) binding site [chemical binding]; other site 523796000446 active site 523796000447 putative substrate binding site [chemical binding]; other site 523796000448 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 523796000449 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 523796000450 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 523796000451 active site 523796000452 homodimer interface [polypeptide binding]; other site 523796000453 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 523796000454 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 523796000455 trimer interface [polypeptide binding]; other site 523796000456 active site 523796000457 substrate binding site [chemical binding]; other site 523796000458 CoA binding site [chemical binding]; other site 523796000459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 523796000460 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523796000461 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 523796000462 O-Antigen ligase; Region: Wzy_C; pfam04932 523796000463 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 523796000464 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 523796000465 Bacterial sugar transferase; Region: Bac_transf; pfam02397 523796000466 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 523796000467 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 523796000468 putative NAD(P) binding site [chemical binding]; other site 523796000469 active site 523796000470 putative substrate binding site [chemical binding]; other site 523796000471 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 523796000472 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 523796000473 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 523796000474 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 523796000475 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 523796000476 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 523796000477 active site 523796000478 homodimer interface [polypeptide binding]; other site 523796000479 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 523796000480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 523796000481 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 523796000482 NAD(P) binding site [chemical binding]; other site 523796000483 catalytic residues [active] 523796000484 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 523796000485 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 523796000486 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 523796000487 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 523796000488 Walker A/P-loop; other site 523796000489 ATP binding site [chemical binding]; other site 523796000490 Q-loop/lid; other site 523796000491 ABC transporter signature motif; other site 523796000492 Walker B; other site 523796000493 D-loop; other site 523796000494 H-loop/switch region; other site 523796000495 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 523796000496 NMT1-like family; Region: NMT1_2; cl17432 523796000497 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 523796000498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 523796000499 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 523796000500 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 523796000501 active site 523796000502 Uncharacterized conserved protein [Function unknown]; Region: COG5609 523796000503 formate dehydrogenase; Provisional; Region: PRK07574 523796000504 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 523796000505 dimerization interface [polypeptide binding]; other site 523796000506 ligand binding site [chemical binding]; other site 523796000507 NAD binding site [chemical binding]; other site 523796000508 catalytic site [active] 523796000509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796000510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796000511 putative substrate translocation pore; other site 523796000512 Condensation domain; Region: Condensation; cl19241 523796000513 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 523796000514 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 523796000515 acyl-activating enzyme (AAE) consensus motif; other site 523796000516 AMP binding site [chemical binding]; other site 523796000517 active site 523796000518 CoA binding site [chemical binding]; other site 523796000519 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 523796000520 Condensation domain; Region: Condensation; pfam00668 523796000521 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 523796000522 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 523796000523 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 523796000524 acyl-activating enzyme (AAE) consensus motif; other site 523796000525 AMP binding site [chemical binding]; other site 523796000526 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 523796000527 thioester reductase domain; Region: Thioester-redct; TIGR01746 523796000528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523796000529 NAD(P) binding site [chemical binding]; other site 523796000530 active site 523796000531 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 523796000532 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 523796000533 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 523796000534 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 523796000535 nucleotide binding site [chemical binding]; other site 523796000536 N-acetyl-L-glutamate binding site [chemical binding]; other site 523796000537 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 523796000538 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 523796000539 heterotetramer interface [polypeptide binding]; other site 523796000540 active site pocket [active] 523796000541 cleavage site 523796000542 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 523796000543 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 523796000544 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 523796000545 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523796000546 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 523796000547 inhibitor-cofactor binding pocket; inhibition site 523796000548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796000549 catalytic residue [active] 523796000550 Amidohydrolase; Region: Amidohydro_2; pfam04909 523796000551 active site 523796000552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523796000553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523796000554 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 523796000555 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 523796000556 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 523796000557 catalytic triad [active] 523796000558 conserved cis-peptide bond; other site 523796000559 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 523796000560 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 523796000561 dimer interface [polypeptide binding]; other site 523796000562 PYR/PP interface [polypeptide binding]; other site 523796000563 TPP binding site [chemical binding]; other site 523796000564 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 523796000565 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 523796000566 TPP-binding site [chemical binding]; other site 523796000567 dimer interface [polypeptide binding]; other site 523796000568 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523796000569 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 523796000570 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523796000571 active site turn [active] 523796000572 phosphorylation site [posttranslational modification] 523796000573 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 523796000574 HPr interaction site; other site 523796000575 glycerol kinase (GK) interaction site [polypeptide binding]; other site 523796000576 active site 523796000577 phosphorylation site [posttranslational modification] 523796000578 Uncharacterized conserved protein [Function unknown]; Region: COG3589 523796000579 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 523796000580 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 523796000581 putative active site [active] 523796000582 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 523796000583 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523796000584 active site turn [active] 523796000585 phosphorylation site [posttranslational modification] 523796000586 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523796000587 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 523796000588 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 523796000589 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 523796000590 putative active site [active] 523796000591 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 523796000592 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 523796000593 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796000594 ATP binding site [chemical binding]; other site 523796000595 putative Mg++ binding site [ion binding]; other site 523796000596 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 523796000597 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 523796000598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523796000599 Walker A/P-loop; other site 523796000600 ATP binding site [chemical binding]; other site 523796000601 Q-loop/lid; other site 523796000602 ABC transporter signature motif; other site 523796000603 Walker B; other site 523796000604 D-loop; other site 523796000605 H-loop/switch region; other site 523796000606 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523796000607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523796000608 Walker A/P-loop; other site 523796000609 ATP binding site [chemical binding]; other site 523796000610 Q-loop/lid; other site 523796000611 ABC transporter signature motif; other site 523796000612 Walker B; other site 523796000613 D-loop; other site 523796000614 H-loop/switch region; other site 523796000615 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523796000616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796000617 dimer interface [polypeptide binding]; other site 523796000618 conserved gate region; other site 523796000619 putative PBP binding loops; other site 523796000620 ABC-ATPase subunit interface; other site 523796000621 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 523796000622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796000623 dimer interface [polypeptide binding]; other site 523796000624 conserved gate region; other site 523796000625 putative PBP binding loops; other site 523796000626 ABC-ATPase subunit interface; other site 523796000627 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 523796000628 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 523796000629 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 523796000630 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 523796000631 Protein of unknown function, DUF576; Region: DUF576; cl04553 523796000632 azoreductase; Reviewed; Region: PRK00170 523796000633 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 523796000634 Peptidase family M23; Region: Peptidase_M23; pfam01551 523796000635 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 523796000636 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 523796000637 Walker A/P-loop; other site 523796000638 ATP binding site [chemical binding]; other site 523796000639 Q-loop/lid; other site 523796000640 ABC transporter signature motif; other site 523796000641 Walker B; other site 523796000642 D-loop; other site 523796000643 H-loop/switch region; other site 523796000644 TOBE domain; Region: TOBE; pfam03459 523796000645 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 523796000646 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 523796000647 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 523796000648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796000649 dimer interface [polypeptide binding]; other site 523796000650 conserved gate region; other site 523796000651 putative PBP binding loops; other site 523796000652 ABC-ATPase subunit interface; other site 523796000653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 523796000654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796000655 dimer interface [polypeptide binding]; other site 523796000656 conserved gate region; other site 523796000657 putative PBP binding loops; other site 523796000658 ABC-ATPase subunit interface; other site 523796000659 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 523796000660 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 523796000661 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 523796000662 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 523796000663 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 523796000664 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 523796000665 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 523796000666 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 523796000667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 523796000668 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 523796000669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796000670 putative substrate translocation pore; other site 523796000671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796000672 active site 523796000673 phosphorylation site [posttranslational modification] 523796000674 intermolecular recognition site; other site 523796000675 dimerization interface [polypeptide binding]; other site 523796000676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523796000677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523796000678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523796000679 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 523796000680 Histidine kinase; Region: His_kinase; pfam06580 523796000681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796000682 ATP binding site [chemical binding]; other site 523796000683 Mg2+ binding site [ion binding]; other site 523796000684 G-X-G motif; other site 523796000685 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 523796000686 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 523796000687 Pyruvate formate lyase 1; Region: PFL1; cd01678 523796000688 coenzyme A binding site [chemical binding]; other site 523796000689 active site 523796000690 catalytic residues [active] 523796000691 glycine loop; other site 523796000692 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 523796000693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796000694 FeS/SAM binding site; other site 523796000695 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 523796000696 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 523796000697 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 523796000698 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 523796000699 putative active site [active] 523796000700 catalytic site [active] 523796000701 putative metal binding site [ion binding]; other site 523796000702 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 523796000703 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 523796000704 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 523796000705 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 523796000706 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 523796000707 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 523796000708 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 523796000709 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 523796000710 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 523796000711 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 523796000712 dimer interface [polypeptide binding]; other site 523796000713 active site 523796000714 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 523796000715 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 523796000716 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 523796000717 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 523796000718 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 523796000719 substrate binding site [chemical binding]; other site 523796000720 oxyanion hole (OAH) forming residues; other site 523796000721 trimer interface [polypeptide binding]; other site 523796000722 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 523796000723 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 523796000724 active site 523796000725 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 523796000726 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 523796000727 acyl-activating enzyme (AAE) consensus motif; other site 523796000728 AMP binding site [chemical binding]; other site 523796000729 active site 523796000730 CoA binding site [chemical binding]; other site 523796000731 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 523796000732 Coenzyme A transferase; Region: CoA_trans; smart00882 523796000733 Coenzyme A transferase; Region: CoA_trans; cl17247 523796000734 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 523796000735 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 523796000736 catalytic triad [active] 523796000737 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 523796000738 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 523796000739 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 523796000740 Protein of unknown function, DUF488; Region: DUF488; cl01246 523796000741 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 523796000742 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 523796000743 heme-binding site [chemical binding]; other site 523796000744 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 523796000745 FAD binding pocket [chemical binding]; other site 523796000746 FAD binding motif [chemical binding]; other site 523796000747 phosphate binding motif [ion binding]; other site 523796000748 beta-alpha-beta structure motif; other site 523796000749 NAD binding pocket [chemical binding]; other site 523796000750 Heme binding pocket [chemical binding]; other site 523796000751 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 523796000752 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 523796000753 tetramer (dimer of dimers) interface [polypeptide binding]; other site 523796000754 NAD binding site [chemical binding]; other site 523796000755 dimer interface [polypeptide binding]; other site 523796000756 substrate binding site [chemical binding]; other site 523796000757 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523796000758 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 523796000759 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523796000760 active site turn [active] 523796000761 phosphorylation site [posttranslational modification] 523796000762 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 523796000763 active site 523796000764 tetramer interface [polypeptide binding]; other site 523796000765 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 523796000766 Mga helix-turn-helix domain; Region: Mga; pfam05043 523796000767 PRD domain; Region: PRD; pfam00874 523796000768 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 523796000769 active site 523796000770 P-loop; other site 523796000771 phosphorylation site [posttranslational modification] 523796000772 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523796000773 active site 523796000774 phosphorylation site [posttranslational modification] 523796000775 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523796000776 active site 523796000777 phosphorylation site [posttranslational modification] 523796000778 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 523796000779 active site 523796000780 P-loop; other site 523796000781 phosphorylation site [posttranslational modification] 523796000782 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 523796000783 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 523796000784 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 523796000785 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 523796000786 putative NAD(P) binding site [chemical binding]; other site 523796000787 catalytic Zn binding site [ion binding]; other site 523796000788 structural Zn binding site [ion binding]; other site 523796000789 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 523796000790 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 523796000791 putative NAD(P) binding site [chemical binding]; other site 523796000792 catalytic Zn binding site [ion binding]; other site 523796000793 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 523796000794 substrate binding site; other site 523796000795 dimer interface; other site 523796000796 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 523796000797 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 523796000798 NAD(P) binding site [chemical binding]; other site 523796000799 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 523796000800 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 523796000801 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 523796000802 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 523796000803 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 523796000804 substrate binding site; other site 523796000805 dimer interface; other site 523796000806 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 523796000807 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 523796000808 putative NAD(P) binding site [chemical binding]; other site 523796000809 putative catalytic Zn binding site [ion binding]; other site 523796000810 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 523796000811 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 523796000812 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 523796000813 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 523796000814 active site 523796000815 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 523796000816 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 523796000817 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 523796000818 Fe binding site [ion binding]; other site 523796000819 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 523796000820 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 523796000821 GAF domain; Region: GAF; pfam01590 523796000822 Histidine kinase; Region: His_kinase; pfam06580 523796000823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796000824 ATP binding site [chemical binding]; other site 523796000825 Mg2+ binding site [ion binding]; other site 523796000826 G-X-G motif; other site 523796000827 two-component response regulator; Provisional; Region: PRK14084 523796000828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796000829 active site 523796000830 phosphorylation site [posttranslational modification] 523796000831 intermolecular recognition site; other site 523796000832 dimerization interface [polypeptide binding]; other site 523796000833 LytTr DNA-binding domain; Region: LytTR; pfam04397 523796000834 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 523796000835 antiholin-like protein LrgB; Provisional; Region: PRK04288 523796000836 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 523796000837 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 523796000838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523796000839 DNA-binding site [nucleotide binding]; DNA binding site 523796000840 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 523796000841 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 523796000842 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 523796000843 HPr interaction site; other site 523796000844 glycerol kinase (GK) interaction site [polypeptide binding]; other site 523796000845 active site 523796000846 phosphorylation site [posttranslational modification] 523796000847 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 523796000848 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 523796000849 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523796000850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796000851 S-adenosylmethionine binding site [chemical binding]; other site 523796000852 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 523796000853 substrate binding site [chemical binding]; other site 523796000854 dimer interface [polypeptide binding]; other site 523796000855 ATP binding site [chemical binding]; other site 523796000856 D-ribose pyranase; Provisional; Region: PRK11797 523796000857 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 523796000858 Sugar transport protein; Region: Sugar_transport; pfam06800 523796000859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 523796000860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 523796000861 DNA binding site [nucleotide binding] 523796000862 domain linker motif; other site 523796000863 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 523796000864 dimerization interface [polypeptide binding]; other site 523796000865 ligand binding site [chemical binding]; other site 523796000866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796000867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796000868 putative substrate translocation pore; other site 523796000869 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 523796000870 active site 523796000871 Surface antigen [General function prediction only]; Region: COG3942 523796000872 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 523796000873 Peptidase family M23; Region: Peptidase_M23; pfam01551 523796000874 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 523796000875 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 523796000876 Walker A/P-loop; other site 523796000877 ATP binding site [chemical binding]; other site 523796000878 Q-loop/lid; other site 523796000879 ABC transporter signature motif; other site 523796000880 Walker B; other site 523796000881 D-loop; other site 523796000882 H-loop/switch region; other site 523796000883 Surface antigen [General function prediction only]; Region: COG3942 523796000884 CHAP domain; Region: CHAP; pfam05257 523796000885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 523796000886 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 523796000887 Predicted membrane protein [Function unknown]; Region: COG1511 523796000888 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 523796000889 heterodimer interface [polypeptide binding]; other site 523796000890 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 523796000891 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 523796000892 Uncharacterized small protein [Function unknown]; Region: COG5417 523796000893 Predicted membrane protein [Function unknown]; Region: COG4499 523796000894 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 523796000895 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 523796000896 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523796000897 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523796000898 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 523796000899 LXG domain of WXG superfamily; Region: LXG; pfam04740 523796000900 Protein of unknown function, DUF600; Region: DUF600; cl04640 523796000901 Protein of unknown function, DUF600; Region: DUF600; cl04640 523796000902 Protein of unknown function, DUF600; Region: DUF600; cl04640 523796000903 Protein of unknown function, DUF600; Region: DUF600; cl04640 523796000904 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 523796000905 Domain of unknown function with cystatin-like fold (DUF4467); Region: DUF4467; pfam14729 523796000906 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 523796000907 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 523796000908 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 523796000909 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 523796000910 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 523796000911 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 523796000912 FtsX-like permease family; Region: FtsX; pfam02687 523796000913 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 523796000914 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523796000915 Walker A/P-loop; other site 523796000916 ATP binding site [chemical binding]; other site 523796000917 Q-loop/lid; other site 523796000918 ABC transporter signature motif; other site 523796000919 Walker B; other site 523796000920 D-loop; other site 523796000921 H-loop/switch region; other site 523796000922 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 523796000923 putative kinase; Provisional; Region: PRK09954 523796000924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796000925 non-specific DNA binding site [nucleotide binding]; other site 523796000926 salt bridge; other site 523796000927 sequence-specific DNA binding site [nucleotide binding]; other site 523796000928 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 523796000929 substrate binding site [chemical binding]; other site 523796000930 ATP binding site [chemical binding]; other site 523796000931 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 523796000932 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 523796000933 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 523796000934 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 523796000935 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 523796000936 Na binding site [ion binding]; other site 523796000937 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 523796000938 inhibitor site; inhibition site 523796000939 active site 523796000940 dimer interface [polypeptide binding]; other site 523796000941 catalytic residue [active] 523796000942 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 523796000943 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 523796000944 nucleotide binding site [chemical binding]; other site 523796000945 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 523796000946 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 523796000947 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 523796000948 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 523796000949 putative active site [active] 523796000950 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 523796000951 putative active site cavity [active] 523796000952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 523796000953 Nucleoside recognition; Region: Gate; pfam07670 523796000954 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 523796000955 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 523796000956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523796000957 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 523796000958 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 523796000959 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 523796000960 Int/Topo IB signature motif; other site 523796000961 Domain of unknown function (DUF955); Region: DUF955; pfam06114 523796000962 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523796000963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796000964 non-specific DNA binding site [nucleotide binding]; other site 523796000965 salt bridge; other site 523796000966 sequence-specific DNA binding site [nucleotide binding]; other site 523796000967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 523796000968 non-specific DNA binding site [nucleotide binding]; other site 523796000969 salt bridge; other site 523796000970 sequence-specific DNA binding site [nucleotide binding]; other site 523796000971 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 523796000972 Homeodomain-like domain; Region: HTH_23; pfam13384 523796000973 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 523796000974 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 523796000975 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 523796000976 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 523796000977 active site 523796000978 DNA binding site [nucleotide binding] 523796000979 catalytic site [active] 523796000980 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 523796000981 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 523796000982 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 523796000983 YopX protein; Region: YopX; pfam09643 523796000984 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 523796000985 dUTPase; Region: dUTPase_2; pfam08761 523796000986 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 523796000987 active site 523796000988 homodimer interface [polypeptide binding]; other site 523796000989 metal binding site [ion binding]; metal-binding site 523796000990 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 523796000991 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 523796000992 Transcriptional activator RinB; Region: RinB; pfam06116 523796000993 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 523796000994 Virulence-associated protein E; Region: VirE; pfam05272 523796000995 VRR-NUC domain; Region: VRR_NUC; pfam08774 523796000996 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 523796000997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796000998 ATP binding site [chemical binding]; other site 523796000999 putative Mg++ binding site [ion binding]; other site 523796001000 helicase superfamily c-terminal domain; Region: HELICc; smart00490 523796001001 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 523796001002 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 523796001003 active site 523796001004 Phage terminase, small subunit; Region: Terminase_4; pfam05119 523796001005 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 523796001006 Phage Terminase; Region: Terminase_1; cl19862 523796001007 Phage-related protein [Function unknown]; Region: COG4695; cl01923 523796001008 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 523796001009 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 523796001010 oligomer interface [polypeptide binding]; other site 523796001011 active site residues [active] 523796001012 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 523796001013 Phage capsid family; Region: Phage_capsid; pfam05065 523796001014 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 523796001015 oligomerization interface [polypeptide binding]; other site 523796001016 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 523796001017 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 523796001018 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 523796001019 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 523796001020 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 523796001021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 523796001022 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 523796001023 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 523796001024 Stathmin family; Region: Stathmin; pfam00836 523796001025 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 523796001026 Peptidase family M23; Region: Peptidase_M23; pfam01551 523796001027 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523796001028 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523796001029 catalytic residue [active] 523796001030 Phage tail protein; Region: Sipho_tail; pfam05709 523796001031 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 523796001032 hypothetical protein; Provisional; Region: PRK05926 523796001033 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 523796001034 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 523796001035 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 523796001036 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 523796001037 holin, SPP1 family; Region: holin_SPP1; TIGR01592 523796001038 CHAP domain; Region: CHAP; pfam05257 523796001039 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 523796001040 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 523796001041 active site 523796001042 metal binding site [ion binding]; metal-binding site 523796001043 Bacterial SH3 domain homologues; Region: SH3b; smart00287 523796001044 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 523796001045 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 523796001046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523796001047 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 523796001048 putative active site [active] 523796001049 putative FMN binding site [chemical binding]; other site 523796001050 putative substrate binding site [chemical binding]; other site 523796001051 putative catalytic residue [active] 523796001052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 523796001053 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 523796001054 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 523796001055 lipoyl attachment site [posttranslational modification]; other site 523796001056 Replication protein C N-terminal domain; Region: RP-C; pfam03428 523796001057 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 523796001058 putative ADP-ribose binding site [chemical binding]; other site 523796001059 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 523796001060 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 523796001061 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 523796001062 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 523796001063 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 523796001064 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 523796001065 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 523796001066 NADP binding site [chemical binding]; other site 523796001067 putative substrate binding site [chemical binding]; other site 523796001068 active site 523796001069 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 523796001070 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 523796001071 active site 523796001072 P-loop; other site 523796001073 phosphorylation site [posttranslational modification] 523796001074 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523796001075 active site 523796001076 phosphorylation site [posttranslational modification] 523796001077 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 523796001078 HTH domain; Region: HTH_11; pfam08279 523796001079 HTH domain; Region: HTH_11; pfam08279 523796001080 PRD domain; Region: PRD; pfam00874 523796001081 PRD domain; Region: PRD; pfam00874 523796001082 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 523796001083 active site 523796001084 P-loop; other site 523796001085 phosphorylation site [posttranslational modification] 523796001086 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523796001087 active site 523796001088 phosphorylation site [posttranslational modification] 523796001089 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796001090 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 523796001091 putative DNA binding site [nucleotide binding]; other site 523796001092 putative Zn2+ binding site [ion binding]; other site 523796001093 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 523796001094 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 523796001095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 523796001096 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 523796001097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796001098 putative substrate translocation pore; other site 523796001099 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 523796001100 Zn binding site [ion binding]; other site 523796001101 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 523796001102 Zn binding site [ion binding]; other site 523796001103 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 523796001104 Predicted flavoprotein [General function prediction only]; Region: COG0431 523796001105 Predicted membrane protein [Function unknown]; Region: COG2855 523796001106 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 523796001107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 523796001108 Imelysin; Region: Peptidase_M75; pfam09375 523796001109 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 523796001110 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 523796001111 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 523796001112 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 523796001113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796001114 non-specific DNA binding site [nucleotide binding]; other site 523796001115 salt bridge; other site 523796001116 sequence-specific DNA binding site [nucleotide binding]; other site 523796001117 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 523796001118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 523796001119 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 523796001120 Walker A/P-loop; other site 523796001121 ATP binding site [chemical binding]; other site 523796001122 Q-loop/lid; other site 523796001123 ABC transporter signature motif; other site 523796001124 Walker B; other site 523796001125 D-loop; other site 523796001126 H-loop/switch region; other site 523796001127 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 523796001128 Predicted membrane protein [Function unknown]; Region: COG4292 523796001129 putative acyltransferase; Provisional; Region: PRK05790 523796001130 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 523796001131 dimer interface [polypeptide binding]; other site 523796001132 active site 523796001133 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 523796001134 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 523796001135 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 523796001136 THF binding site; other site 523796001137 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 523796001138 substrate binding site [chemical binding]; other site 523796001139 THF binding site; other site 523796001140 zinc-binding site [ion binding]; other site 523796001141 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 523796001142 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 523796001143 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 523796001144 FAD binding site [chemical binding]; other site 523796001145 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 523796001146 homodimer interface [polypeptide binding]; other site 523796001147 substrate-cofactor binding pocket; other site 523796001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796001149 catalytic residue [active] 523796001150 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 523796001151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523796001152 catalytic residue [active] 523796001153 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 523796001154 ParB-like nuclease domain; Region: ParB; smart00470 523796001155 KorB domain; Region: KorB; pfam08535 523796001156 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 523796001157 Mechanosensitive ion channel; Region: MS_channel; pfam00924 523796001158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 523796001159 GTP-binding protein YchF; Reviewed; Region: PRK09601 523796001160 YchF GTPase; Region: YchF; cd01900 523796001161 G1 box; other site 523796001162 GTP/Mg2+ binding site [chemical binding]; other site 523796001163 Switch I region; other site 523796001164 G2 box; other site 523796001165 Switch II region; other site 523796001166 G3 box; other site 523796001167 G4 box; other site 523796001168 G5 box; other site 523796001169 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 523796001170 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 523796001171 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 523796001172 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 523796001173 dimer interface [polypeptide binding]; other site 523796001174 ssDNA binding site [nucleotide binding]; other site 523796001175 tetramer (dimer of dimers) interface [polypeptide binding]; other site 523796001176 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 523796001177 superantigen-like protein; Reviewed; Region: PRK13042 523796001178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 523796001179 Predicted membrane protein [Function unknown]; Region: COG3212 523796001180 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523796001181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796001182 non-specific DNA binding site [nucleotide binding]; other site 523796001183 salt bridge; other site 523796001184 sequence-specific DNA binding site [nucleotide binding]; other site 523796001185 Predicted membrane protein [Function unknown]; Region: COG2261 523796001186 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523796001187 catalytic core [active] 523796001188 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 523796001189 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 523796001190 catalytic residue [active] 523796001191 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 523796001192 catalytic residues [active] 523796001193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796001194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796001195 peroxiredoxin; Region: AhpC; TIGR03137 523796001196 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 523796001197 dimer interface [polypeptide binding]; other site 523796001198 decamer (pentamer of dimers) interface [polypeptide binding]; other site 523796001199 catalytic triad [active] 523796001200 peroxidatic and resolving cysteines [active] 523796001201 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 523796001202 dimer interface [polypeptide binding]; other site 523796001203 FMN binding site [chemical binding]; other site 523796001204 NADPH bind site [chemical binding]; other site 523796001205 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 523796001206 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 523796001207 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796001208 active site 523796001209 Sulfate transporter family; Region: Sulfate_transp; cl19250 523796001210 xanthine permease; Region: pbuX; TIGR03173 523796001211 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 523796001212 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 523796001213 active site 523796001214 GMP synthase; Reviewed; Region: guaA; PRK00074 523796001215 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 523796001216 AMP/PPi binding site [chemical binding]; other site 523796001217 candidate oxyanion hole; other site 523796001218 catalytic triad [active] 523796001219 potential glutamine specificity residues [chemical binding]; other site 523796001220 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 523796001221 ATP Binding subdomain [chemical binding]; other site 523796001222 Ligand Binding sites [chemical binding]; other site 523796001223 Dimerization subdomain; other site 523796001224 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 523796001225 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 523796001226 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 523796001227 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 523796001228 Int/Topo IB signature motif; other site 523796001229 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523796001230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796001231 non-specific DNA binding site [nucleotide binding]; other site 523796001232 salt bridge; other site 523796001233 sequence-specific DNA binding site [nucleotide binding]; other site 523796001234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796001235 non-specific DNA binding site [nucleotide binding]; other site 523796001236 salt bridge; other site 523796001237 sequence-specific DNA binding site [nucleotide binding]; other site 523796001238 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 523796001239 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 523796001240 nucleotide binding site [chemical binding]; other site 523796001241 D5 N terminal like; Region: D5_N; smart00885 523796001242 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 523796001243 Coat F domain; Region: Coat_F; cl17715 523796001244 adenosine deaminase; Provisional; Region: PRK09358 523796001245 active site 523796001246 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 523796001247 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 523796001248 PemK-like protein; Region: PemK; pfam02452 523796001249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 523796001250 Transposase; Region: HTH_Tnp_1; cl17663 523796001251 Predicted membrane protein [Function unknown]; Region: COG3759 523796001252 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 523796001253 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 523796001254 NADP binding site [chemical binding]; other site 523796001255 superantigen-like protein; Reviewed; Region: PRK13037 523796001256 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 523796001257 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796001258 superantigen-like protein; Reviewed; Region: PRK13041 523796001259 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 523796001260 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796001261 superantigen-like protein; Reviewed; Region: PRK13335 523796001262 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 523796001263 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796001264 superantigen-like protein; Reviewed; Region: PRK13335 523796001265 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 523796001266 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796001267 superantigen-like protein 5; Reviewed; Region: PRK13035 523796001268 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 523796001269 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796001270 superantigen-like protein 7; Reviewed; Region: PRK13346 523796001271 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 523796001272 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796001273 superantigen-like protein; Reviewed; Region: PRK13345 523796001274 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 523796001275 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796001276 superantigen-like protein; Reviewed; Region: PRK13038 523796001277 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 523796001278 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796001279 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 523796001280 HsdM N-terminal domain; Region: HsdM_N; pfam12161 523796001281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796001282 S-adenosylmethionine binding site [chemical binding]; other site 523796001283 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 523796001284 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 523796001285 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 523796001286 superantigen-like protein; Reviewed; Region: PRK13036 523796001287 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 523796001288 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796001289 Protein of unknown function, DUF576; Region: DUF576; pfam04507 523796001290 Protein of unknown function, DUF576; Region: DUF576; pfam04507 523796001291 Protein of unknown function, DUF576; Region: DUF576; pfam04507 523796001292 Protein of unknown function, DUF576; Region: DUF576; pfam04507 523796001293 Protein of unknown function, DUF576; Region: DUF576; cl04553 523796001294 Protein of unknown function, DUF576; Region: DUF576; cl04553 523796001295 Protein of unknown function, DUF576; Region: DUF576; cl04553 523796001296 Protein of unknown function, DUF576; Region: DUF576; cl04553 523796001297 Protein of unknown function, DUF576; Region: DUF576; pfam04507 523796001298 Domain of unknown function (DUF3498); Region: DUF3498; pfam12004 523796001299 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 523796001300 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 523796001301 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 523796001302 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 523796001303 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523796001304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 523796001305 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 523796001306 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 523796001307 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 523796001308 active site 523796001309 Esterase/lipase [General function prediction only]; Region: COG1647 523796001310 Putative lysophospholipase; Region: Hydrolase_4; cl19140 523796001311 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 523796001312 Na2 binding site [ion binding]; other site 523796001313 putative substrate binding site 1 [chemical binding]; other site 523796001314 Na binding site 1 [ion binding]; other site 523796001315 putative substrate binding site 2 [chemical binding]; other site 523796001316 cysteine synthase; Region: PLN02565 523796001317 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 523796001318 dimer interface [polypeptide binding]; other site 523796001319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796001320 catalytic residue [active] 523796001321 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 523796001322 homodimer interface [polypeptide binding]; other site 523796001323 substrate-cofactor binding pocket; other site 523796001324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796001325 catalytic residue [active] 523796001326 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 523796001327 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 523796001328 Walker A/P-loop; other site 523796001329 ATP binding site [chemical binding]; other site 523796001330 Q-loop/lid; other site 523796001331 ABC transporter signature motif; other site 523796001332 Walker B; other site 523796001333 D-loop; other site 523796001334 H-loop/switch region; other site 523796001335 NIL domain; Region: NIL; pfam09383 523796001336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796001337 dimer interface [polypeptide binding]; other site 523796001338 conserved gate region; other site 523796001339 ABC-ATPase subunit interface; other site 523796001340 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 523796001341 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523796001342 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 523796001343 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523796001344 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523796001345 Surface antigen [General function prediction only]; Region: COG3942 523796001346 CHAP domain; Region: CHAP; pfam05257 523796001347 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 523796001348 nudix motif; other site 523796001349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796001350 Coenzyme A binding pocket [chemical binding]; other site 523796001351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 523796001352 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 523796001353 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 523796001354 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523796001355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523796001356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 523796001357 dimerization interface [polypeptide binding]; other site 523796001358 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 523796001359 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 523796001360 active site 523796001361 dimer interface [polypeptide binding]; other site 523796001362 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 523796001363 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 523796001364 active site 523796001365 FMN binding site [chemical binding]; other site 523796001366 substrate binding site [chemical binding]; other site 523796001367 3Fe-4S cluster binding site [ion binding]; other site 523796001368 Glutamate synthase domain 3 [Amino acid transport and metabolism]; Region: GltB; COG0070 523796001369 domain_subunit interface; other site 523796001370 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 523796001371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 523796001372 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 523796001373 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523796001374 active site turn [active] 523796001375 phosphorylation site [posttranslational modification] 523796001376 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523796001377 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 523796001378 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 523796001379 Ca binding site [ion binding]; other site 523796001380 active site 523796001381 catalytic site [active] 523796001382 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 523796001383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523796001384 DNA-binding site [nucleotide binding]; DNA binding site 523796001385 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 523796001386 UTRA domain; Region: UTRA; pfam07702 523796001387 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 523796001388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796001389 Coenzyme A binding pocket [chemical binding]; other site 523796001390 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 523796001391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796001392 Walker A motif; other site 523796001393 ATP binding site [chemical binding]; other site 523796001394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 523796001395 Walker B motif; other site 523796001396 arginine finger; other site 523796001397 hypothetical protein; Validated; Region: PRK00153 523796001398 recombination protein RecR; Reviewed; Region: recR; PRK00076 523796001399 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 523796001400 RecR protein; Region: RecR; pfam02132 523796001401 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 523796001402 putative active site [active] 523796001403 putative metal-binding site [ion binding]; other site 523796001404 tetramer interface [polypeptide binding]; other site 523796001405 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 523796001406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 523796001407 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523796001408 catalytic residue [active] 523796001409 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 523796001410 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 523796001411 thymidylate kinase; Validated; Region: tmk; PRK00698 523796001412 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 523796001413 TMP-binding site; other site 523796001414 ATP-binding site [chemical binding]; other site 523796001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 523796001416 DNA polymerase III subunit delta'; Validated; Region: PRK08058 523796001417 DNA polymerase III subunit delta'; Validated; Region: PRK08485 523796001418 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 523796001419 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 523796001420 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 523796001421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796001422 S-adenosylmethionine binding site [chemical binding]; other site 523796001423 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 523796001424 GIY-YIG motif/motif A; other site 523796001425 putative active site [active] 523796001426 putative metal binding site [ion binding]; other site 523796001427 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 523796001428 putative SAM binding site [chemical binding]; other site 523796001429 putative homodimer interface [polypeptide binding]; other site 523796001430 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 523796001431 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 523796001432 active site 523796001433 HIGH motif; other site 523796001434 KMSKS motif; other site 523796001435 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 523796001436 tRNA binding surface [nucleotide binding]; other site 523796001437 anticodon binding site; other site 523796001438 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 523796001439 dimer interface [polypeptide binding]; other site 523796001440 putative tRNA-binding site [nucleotide binding]; other site 523796001441 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 523796001442 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 523796001443 active site 523796001444 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 523796001445 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 523796001446 putative active site [active] 523796001447 putative metal binding site [ion binding]; other site 523796001448 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 523796001449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796001450 S-adenosylmethionine binding site [chemical binding]; other site 523796001451 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 523796001452 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 523796001453 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 523796001454 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 523796001455 pur operon repressor; Provisional; Region: PRK09213 523796001456 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 523796001457 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796001458 active site 523796001459 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 523796001460 homotrimer interaction site [polypeptide binding]; other site 523796001461 putative active site [active] 523796001462 regulatory protein SpoVG; Reviewed; Region: PRK13259 523796001463 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 523796001464 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 523796001465 Substrate binding site; other site 523796001466 Mg++ binding site; other site 523796001467 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 523796001468 active site 523796001469 substrate binding site [chemical binding]; other site 523796001470 CoA binding site [chemical binding]; other site 523796001471 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 523796001472 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 523796001473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796001474 active site 523796001475 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 523796001476 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 523796001477 5S rRNA interface [nucleotide binding]; other site 523796001478 CTC domain interface [polypeptide binding]; other site 523796001479 L16 interface [polypeptide binding]; other site 523796001480 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 523796001481 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 523796001482 putative active site [active] 523796001483 catalytic residue [active] 523796001484 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 523796001485 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 523796001486 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 523796001487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796001488 ATP binding site [chemical binding]; other site 523796001489 putative Mg++ binding site [ion binding]; other site 523796001490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796001491 nucleotide binding region [chemical binding]; other site 523796001492 ATP-binding site [chemical binding]; other site 523796001493 TRCF domain; Region: TRCF; pfam03461 523796001494 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 523796001495 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 523796001496 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 523796001497 putative SAM binding site [chemical binding]; other site 523796001498 putative homodimer interface [polypeptide binding]; other site 523796001499 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 523796001500 homodimer interface [polypeptide binding]; other site 523796001501 metal binding site [ion binding]; metal-binding site 523796001502 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523796001503 RNA binding surface [nucleotide binding]; other site 523796001504 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 523796001505 Septum formation initiator; Region: DivIC; pfam04977 523796001506 hypothetical protein; Provisional; Region: PRK08582 523796001507 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 523796001508 RNA binding site [nucleotide binding]; other site 523796001509 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 523796001510 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 523796001511 Ligand Binding Site [chemical binding]; other site 523796001512 TilS substrate C-terminal domain; Region: TilS_C; smart00977 523796001513 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796001514 active site 523796001515 FtsH Extracellular; Region: FtsH_ext; pfam06480 523796001516 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 523796001517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796001518 Walker A motif; other site 523796001519 ATP binding site [chemical binding]; other site 523796001520 Walker B motif; other site 523796001521 arginine finger; other site 523796001522 Peptidase family M41; Region: Peptidase_M41; pfam01434 523796001523 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 523796001524 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 523796001525 dimerization interface [polypeptide binding]; other site 523796001526 domain crossover interface; other site 523796001527 redox-dependent activation switch; other site 523796001528 cysteine synthase; Region: PLN02565 523796001529 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 523796001530 dimer interface [polypeptide binding]; other site 523796001531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796001532 catalytic residue [active] 523796001533 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 523796001534 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 523796001535 substrate binding pocket [chemical binding]; other site 523796001536 dimer interface [polypeptide binding]; other site 523796001537 inhibitor binding site; inhibition site 523796001538 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 523796001539 homooctamer interface [polypeptide binding]; other site 523796001540 active site 523796001541 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 523796001542 catalytic center binding site [active] 523796001543 ATP binding site [chemical binding]; other site 523796001544 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 523796001545 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 523796001546 dimer interface [polypeptide binding]; other site 523796001547 putative anticodon binding site; other site 523796001548 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 523796001549 motif 1; other site 523796001550 active site 523796001551 motif 2; other site 523796001552 motif 3; other site 523796001553 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 523796001554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523796001555 DNA-binding site [nucleotide binding]; DNA binding site 523796001556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523796001557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796001558 homodimer interface [polypeptide binding]; other site 523796001559 catalytic residue [active] 523796001560 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 523796001561 active site 523796001562 multimer interface [polypeptide binding]; other site 523796001563 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 523796001564 predicted active site [active] 523796001565 catalytic triad [active] 523796001566 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 523796001567 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 523796001568 Nucleoside recognition; Region: Gate; pfam07670 523796001569 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 523796001570 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 523796001571 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 523796001572 UvrB/uvrC motif; Region: UVR; pfam02151 523796001573 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 523796001574 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 523796001575 ADP binding site [chemical binding]; other site 523796001576 phosphagen binding site; other site 523796001577 substrate specificity loop; other site 523796001578 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 523796001579 Clp amino terminal domain; Region: Clp_N; pfam02861 523796001580 Clp amino terminal domain; Region: Clp_N; pfam02861 523796001581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796001582 Walker A motif; other site 523796001583 ATP binding site [chemical binding]; other site 523796001584 Walker B motif; other site 523796001585 arginine finger; other site 523796001586 UvrB/uvrC motif; Region: UVR; pfam02151 523796001587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796001588 Walker A motif; other site 523796001589 ATP binding site [chemical binding]; other site 523796001590 Walker B motif; other site 523796001591 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 523796001592 DNA repair protein RadA; Provisional; Region: PRK11823 523796001593 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 523796001594 Walker A motif/ATP binding site; other site 523796001595 ATP binding site [chemical binding]; other site 523796001596 Walker B motif; other site 523796001597 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 523796001598 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 523796001599 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 523796001600 putative active site [active] 523796001601 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 523796001602 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 523796001603 active site 523796001604 HIGH motif; other site 523796001605 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 523796001606 active site 523796001607 KMSKS motif; other site 523796001608 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 523796001609 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 523796001610 trimer interface [polypeptide binding]; other site 523796001611 active site 523796001612 substrate binding site [chemical binding]; other site 523796001613 CoA binding site [chemical binding]; other site 523796001614 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 523796001615 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 523796001616 active site 523796001617 HIGH motif; other site 523796001618 KMSKS motif; other site 523796001619 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 523796001620 tRNA binding surface [nucleotide binding]; other site 523796001621 anticodon binding site; other site 523796001622 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 523796001623 active site 523796001624 dimerization interface [polypeptide binding]; other site 523796001625 metal binding site [ion binding]; metal-binding site 523796001626 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 523796001627 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 523796001628 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 523796001629 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 523796001630 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 523796001631 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523796001632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 523796001633 DNA binding residues [nucleotide binding] 523796001634 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 523796001635 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 523796001636 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 523796001637 putative homodimer interface [polypeptide binding]; other site 523796001638 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 523796001639 heterodimer interface [polypeptide binding]; other site 523796001640 homodimer interface [polypeptide binding]; other site 523796001641 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 523796001642 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 523796001643 23S rRNA interface [nucleotide binding]; other site 523796001644 L7/L12 interface [polypeptide binding]; other site 523796001645 putative thiostrepton binding site; other site 523796001646 L25 interface [polypeptide binding]; other site 523796001647 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 523796001648 mRNA/rRNA interface [nucleotide binding]; other site 523796001649 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 523796001650 23S rRNA interface [nucleotide binding]; other site 523796001651 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 523796001652 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 523796001653 peripheral dimer interface [polypeptide binding]; other site 523796001654 core dimer interface [polypeptide binding]; other site 523796001655 L10 interface [polypeptide binding]; other site 523796001656 L11 interface [polypeptide binding]; other site 523796001657 putative EF-Tu interaction site [polypeptide binding]; other site 523796001658 putative EF-G interaction site [polypeptide binding]; other site 523796001659 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523796001660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796001661 S-adenosylmethionine binding site [chemical binding]; other site 523796001662 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 523796001663 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 523796001664 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 523796001665 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 523796001666 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 523796001667 RPB10 interaction site [polypeptide binding]; other site 523796001668 RPB1 interaction site [polypeptide binding]; other site 523796001669 RPB11 interaction site [polypeptide binding]; other site 523796001670 RPB3 interaction site [polypeptide binding]; other site 523796001671 RPB12 interaction site [polypeptide binding]; other site 523796001672 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 523796001673 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 523796001674 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 523796001675 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 523796001676 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 523796001677 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 523796001678 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 523796001679 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 523796001680 G-loop; other site 523796001681 DNA binding site [nucleotide binding] 523796001682 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 523796001683 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 523796001684 S17 interaction site [polypeptide binding]; other site 523796001685 S8 interaction site; other site 523796001686 16S rRNA interaction site [nucleotide binding]; other site 523796001687 streptomycin interaction site [chemical binding]; other site 523796001688 23S rRNA interaction site [nucleotide binding]; other site 523796001689 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 523796001690 30S ribosomal protein S7; Validated; Region: PRK05302 523796001691 elongation factor G; Reviewed; Region: PRK00007 523796001692 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 523796001693 G1 box; other site 523796001694 putative GEF interaction site [polypeptide binding]; other site 523796001695 GTP/Mg2+ binding site [chemical binding]; other site 523796001696 Switch I region; other site 523796001697 G2 box; other site 523796001698 G3 box; other site 523796001699 Switch II region; other site 523796001700 G4 box; other site 523796001701 G5 box; other site 523796001702 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 523796001703 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 523796001704 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 523796001705 elongation factor Tu; Reviewed; Region: PRK00049 523796001706 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 523796001707 G1 box; other site 523796001708 GEF interaction site [polypeptide binding]; other site 523796001709 GTP/Mg2+ binding site [chemical binding]; other site 523796001710 Switch I region; other site 523796001711 G2 box; other site 523796001712 G3 box; other site 523796001713 Switch II region; other site 523796001714 G4 box; other site 523796001715 G5 box; other site 523796001716 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 523796001717 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 523796001718 Antibiotic Binding Site [chemical binding]; other site 523796001719 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 523796001720 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 523796001721 metal binding site [ion binding]; metal-binding site 523796001722 dimer interface [polypeptide binding]; other site 523796001723 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 523796001724 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 523796001725 substrate-cofactor binding pocket; other site 523796001726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796001727 catalytic residue [active] 523796001728 chaperone protein HchA; Provisional; Region: PRK04155 523796001729 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 523796001730 dimer interface [polypeptide binding]; other site 523796001731 metal binding site [ion binding]; metal-binding site 523796001732 potential oxyanion hole; other site 523796001733 potential catalytic triad [active] 523796001734 conserved cys residue [active] 523796001735 ribulokinase; Provisional; Region: PRK04123 523796001736 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 523796001737 N- and C-terminal domain interface [polypeptide binding]; other site 523796001738 active site 523796001739 MgATP binding site [chemical binding]; other site 523796001740 catalytic site [active] 523796001741 metal binding site [ion binding]; metal-binding site 523796001742 carbohydrate binding site [chemical binding]; other site 523796001743 homodimer interface [polypeptide binding]; other site 523796001744 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 523796001745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523796001746 NAD(P) binding site [chemical binding]; other site 523796001747 active site 523796001748 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 523796001749 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 523796001750 homodimer interface [polypeptide binding]; other site 523796001751 substrate-cofactor binding pocket; other site 523796001752 catalytic residue [active] 523796001753 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 523796001754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796001755 motif II; other site 523796001756 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 523796001757 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 523796001758 Substrate-binding site [chemical binding]; other site 523796001759 Substrate specificity [chemical binding]; other site 523796001760 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 523796001761 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 523796001762 Substrate-binding site [chemical binding]; other site 523796001763 Substrate specificity [chemical binding]; other site 523796001764 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 523796001765 nucleoside/Zn binding site; other site 523796001766 dimer interface [polypeptide binding]; other site 523796001767 catalytic motif [active] 523796001768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796001769 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 523796001770 active site 523796001771 motif I; other site 523796001772 motif II; other site 523796001773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796001774 Predicted flavoprotein [General function prediction only]; Region: COG0431 523796001775 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 523796001776 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 523796001777 Cna protein B-type domain; Region: Cna_B; pfam05738 523796001778 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 523796001779 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 523796001780 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 523796001781 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 523796001782 Cna protein B-type domain; Region: Cna_B; pfam05738 523796001783 Cna protein B-type domain; Region: Cna_B; pfam05738 523796001784 Cna protein B-type domain; Region: Cna_B; pfam05738 523796001785 Cna protein B-type domain; Region: Cna_B; pfam05738 523796001786 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 523796001787 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 523796001788 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 523796001789 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 523796001790 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 523796001791 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 523796001792 Helix-turn-helix domain; Region: HTH_38; pfam13936 523796001793 Homeodomain-like domain; Region: HTH_32; pfam13565 523796001794 Integrase core domain; Region: rve; pfam00665 523796001795 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 523796001796 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 523796001797 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 523796001798 putative GTP cyclohydrolase; Provisional; Region: PRK13674 523796001799 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 523796001800 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 523796001801 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 523796001802 active site 523796001803 trimer interface [polypeptide binding]; other site 523796001804 allosteric site; other site 523796001805 active site lid [active] 523796001806 hexamer (dimer of trimers) interface [polypeptide binding]; other site 523796001807 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 523796001808 active site 523796001809 dimer interface [polypeptide binding]; other site 523796001810 magnesium binding site [ion binding]; other site 523796001811 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 523796001812 tetramer interface [polypeptide binding]; other site 523796001813 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 523796001814 active site 523796001815 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 523796001816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796001817 motif II; other site 523796001818 proline/glycine betaine transporter; Provisional; Region: PRK10642 523796001819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796001820 putative substrate translocation pore; other site 523796001821 acyl-CoA synthetase; Validated; Region: PRK07638 523796001822 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 523796001823 acyl-activating enzyme (AAE) consensus motif; other site 523796001824 AMP binding site [chemical binding]; other site 523796001825 active site 523796001826 CoA binding site [chemical binding]; other site 523796001827 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 523796001828 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 523796001829 dimer interface [polypeptide binding]; other site 523796001830 active site 523796001831 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 523796001832 dimer interface [polypeptide binding]; other site 523796001833 substrate binding site [chemical binding]; other site 523796001834 ATP binding site [chemical binding]; other site 523796001835 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 523796001836 ligand binding site [chemical binding]; other site 523796001837 active site 523796001838 UGI interface [polypeptide binding]; other site 523796001839 catalytic site [active] 523796001840 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 523796001841 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 523796001842 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 523796001843 Uncharacterized conserved protein [Function unknown]; Region: COG3610 523796001844 Uncharacterized conserved protein [Function unknown]; Region: COG2966 523796001845 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 523796001846 putative heme peroxidase; Provisional; Region: PRK12276 523796001847 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 523796001848 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 523796001849 mevalonate kinase; Region: mevalon_kin; TIGR00549 523796001850 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 523796001851 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 523796001852 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 523796001853 diphosphomevalonate decarboxylase; Region: PLN02407 523796001854 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 523796001855 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 523796001856 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 523796001857 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 523796001858 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 523796001859 Squalene epoxidase; Region: SE; cl17314 523796001860 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796001861 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 523796001862 Predicted transcriptional regulator [Transcription]; Region: COG1959 523796001863 Rrf2 family protein; Region: rrf2_super; TIGR00738 523796001864 LXG domain of WXG superfamily; Region: LXG; pfam04740 523796001865 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 523796001866 Protein of unknown function (DUF443); Region: DUF443; pfam04276 523796001867 Protein of unknown function (DUF443); Region: DUF443; pfam04276 523796001868 Protein of unknown function (DUF443); Region: DUF443; pfam04276 523796001869 Protein of unknown function (DUF443); Region: DUF443; pfam04276 523796001870 Protein of unknown function (DUF443); Region: DUF443; pfam04276 523796001871 Protein of unknown function (DUF443); Region: DUF443; pfam04276 523796001872 Protein of unknown function (DUF443); Region: DUF443; pfam04276 523796001873 Protein of unknown function (DUF443); Region: DUF443; pfam04276 523796001874 Protein of unknown function (DUF443); Region: DUF443; pfam04276 523796001875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 523796001876 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 523796001877 active site 523796001878 catalytic tetrad [active] 523796001879 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 523796001880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 523796001881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796001882 Coenzyme A binding pocket [chemical binding]; other site 523796001883 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 523796001884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523796001885 Zn2+ binding site [ion binding]; other site 523796001886 Mg2+ binding site [ion binding]; other site 523796001887 YwhD family; Region: YwhD; pfam08741 523796001888 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 523796001889 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 523796001890 NAD binding site [chemical binding]; other site 523796001891 substrate binding site [chemical binding]; other site 523796001892 catalytic Zn binding site [ion binding]; other site 523796001893 tetramer interface [polypeptide binding]; other site 523796001894 structural Zn binding site [ion binding]; other site 523796001895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 523796001896 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 523796001897 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 523796001898 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 523796001899 active site 523796001900 HIGH motif; other site 523796001901 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523796001902 KMSK motif region; other site 523796001903 tRNA binding surface [nucleotide binding]; other site 523796001904 DALR anticodon binding domain; Region: DALR_1; smart00836 523796001905 anticodon binding site; other site 523796001906 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 523796001907 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 523796001908 minor groove reading motif; other site 523796001909 helix-hairpin-helix signature motif; other site 523796001910 substrate binding pocket [chemical binding]; other site 523796001911 active site 523796001912 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 523796001913 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 523796001914 putative binding site residues; other site 523796001915 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 523796001916 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796001917 ABC-ATPase subunit interface; other site 523796001918 dimer interface [polypeptide binding]; other site 523796001919 putative PBP binding regions; other site 523796001920 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 523796001921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796001922 motif II; other site 523796001923 Putative lysophospholipase; Region: Hydrolase_4; cl19140 523796001924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523796001925 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 523796001926 Putative lysophospholipase; Region: Hydrolase_4; cl19140 523796001927 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 523796001928 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796001929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 523796001930 Protein of unknown function, DUF606; Region: DUF606; pfam04657 523796001931 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 523796001932 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 523796001933 active site 523796001934 DNA binding site [nucleotide binding] 523796001935 Int/Topo IB signature motif; other site 523796001936 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 523796001937 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 523796001938 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523796001939 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 523796001940 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 523796001941 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 523796001942 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 523796001943 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523796001944 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 523796001945 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 523796001946 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 523796001947 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 523796001948 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 523796001949 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 523796001950 metal binding site [ion binding]; metal-binding site 523796001951 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796001952 ABC-ATPase subunit interface; other site 523796001953 dimer interface [polypeptide binding]; other site 523796001954 putative PBP binding regions; other site 523796001955 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 523796001956 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 523796001957 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 523796001958 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 523796001959 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 523796001960 FeoA domain; Region: FeoA; pfam04023 523796001961 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 523796001962 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 523796001963 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 523796001964 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 523796001965 Walker A/P-loop; other site 523796001966 ATP binding site [chemical binding]; other site 523796001967 Q-loop/lid; other site 523796001968 ABC transporter signature motif; other site 523796001969 Walker B; other site 523796001970 D-loop; other site 523796001971 H-loop/switch region; other site 523796001972 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 523796001973 ABC-2 type transporter; Region: ABC2_membrane; cl17235 523796001974 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 523796001975 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523796001976 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 523796001977 active site 523796001978 nucleotide binding site [chemical binding]; other site 523796001979 HIGH motif; other site 523796001980 KMSKS motif; other site 523796001981 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 523796001982 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 523796001983 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 523796001984 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 523796001985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523796001986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796001987 Walker A/P-loop; other site 523796001988 ATP binding site [chemical binding]; other site 523796001989 Q-loop/lid; other site 523796001990 ABC transporter signature motif; other site 523796001991 Walker B; other site 523796001992 D-loop; other site 523796001993 H-loop/switch region; other site 523796001994 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 523796001995 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 523796001996 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 523796001997 Uncharacterized conserved protein [Function unknown]; Region: COG1284 523796001998 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 523796001999 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 523796002000 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 523796002001 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 523796002002 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 523796002003 Walker A/P-loop; other site 523796002004 ATP binding site [chemical binding]; other site 523796002005 Q-loop/lid; other site 523796002006 ABC transporter signature motif; other site 523796002007 Walker B; other site 523796002008 D-loop; other site 523796002009 H-loop/switch region; other site 523796002010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796002011 ABC-ATPase subunit interface; other site 523796002012 dimer interface [polypeptide binding]; other site 523796002013 putative PBP binding regions; other site 523796002014 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 523796002015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796002016 ABC-ATPase subunit interface; other site 523796002017 dimer interface [polypeptide binding]; other site 523796002018 putative PBP binding regions; other site 523796002019 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 523796002020 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 523796002021 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 523796002022 Uncharacterized membrane protein [Function unknown]; Region: COG3949 523796002023 Na binding site [ion binding]; other site 523796002024 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 523796002025 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 523796002026 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 523796002027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796002028 Coenzyme A binding pocket [chemical binding]; other site 523796002029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 523796002030 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 523796002031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523796002032 NAD(P) binding site [chemical binding]; other site 523796002033 active site 523796002034 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523796002035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796002036 active site 523796002037 phosphorylation site [posttranslational modification] 523796002038 intermolecular recognition site; other site 523796002039 dimerization interface [polypeptide binding]; other site 523796002040 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523796002041 DNA binding site [nucleotide binding] 523796002042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523796002043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796002044 ATP binding site [chemical binding]; other site 523796002045 Mg2+ binding site [ion binding]; other site 523796002046 G-X-G motif; other site 523796002047 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 523796002048 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523796002049 Walker A/P-loop; other site 523796002050 ATP binding site [chemical binding]; other site 523796002051 Q-loop/lid; other site 523796002052 ABC transporter signature motif; other site 523796002053 Walker B; other site 523796002054 D-loop; other site 523796002055 H-loop/switch region; other site 523796002056 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 523796002057 FtsX-like permease family; Region: FtsX; pfam02687 523796002058 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 523796002059 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 523796002060 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523796002061 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 523796002062 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523796002063 Surface antigen [General function prediction only]; Region: COG3942 523796002064 CHAP domain; Region: CHAP; pfam05257 523796002065 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 523796002066 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523796002067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523796002068 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 523796002069 hypothetical protein; Provisional; Region: PRK12378 523796002070 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 523796002071 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 523796002072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523796002073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523796002074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 523796002075 dimerization interface [polypeptide binding]; other site 523796002076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796002077 sugar efflux transporter; Region: 2A0120; TIGR00899 523796002078 putative substrate translocation pore; other site 523796002079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 523796002080 Serine incorporator (Serinc); Region: Serinc; pfam03348 523796002081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796002082 Coenzyme A binding pocket [chemical binding]; other site 523796002083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 523796002084 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 523796002085 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 523796002086 hypothetical protein; Validated; Region: PRK00124 523796002087 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 523796002088 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 523796002089 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 523796002090 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523796002091 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 523796002092 Walker A/P-loop; other site 523796002093 ATP binding site [chemical binding]; other site 523796002094 Q-loop/lid; other site 523796002095 ABC transporter signature motif; other site 523796002096 Walker B; other site 523796002097 D-loop; other site 523796002098 H-loop/switch region; other site 523796002099 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 523796002100 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523796002101 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 523796002102 Walker A/P-loop; other site 523796002103 ATP binding site [chemical binding]; other site 523796002104 Q-loop/lid; other site 523796002105 ABC transporter signature motif; other site 523796002106 Walker B; other site 523796002107 D-loop; other site 523796002108 H-loop/switch region; other site 523796002109 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796002110 MarR family; Region: MarR; pfam01047 523796002111 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 523796002112 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 523796002113 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 523796002114 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 523796002115 active site 523796002116 catalytic tetrad [active] 523796002117 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 523796002118 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 523796002119 transmembrane helices; other site 523796002120 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 523796002121 DNA photolyase; Region: DNA_photolyase; pfam00875 523796002122 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 523796002123 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 523796002124 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 523796002125 trimer interface [polypeptide binding]; other site 523796002126 putative Zn binding site [ion binding]; other site 523796002127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796002128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796002129 putative substrate translocation pore; other site 523796002130 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 523796002131 putative deacylase active site [active] 523796002132 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 523796002133 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 523796002134 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 523796002135 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 523796002136 putative substrate binding site [chemical binding]; other site 523796002137 putative ATP binding site [chemical binding]; other site 523796002138 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 523796002139 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523796002140 active site 523796002141 phosphorylation site [posttranslational modification] 523796002142 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 523796002143 active site 523796002144 P-loop; other site 523796002145 phosphorylation site [posttranslational modification] 523796002146 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 523796002147 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 523796002148 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 523796002149 active site 523796002150 dimer interface [polypeptide binding]; other site 523796002151 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 523796002152 Domain of unknown function DUF21; Region: DUF21; pfam01595 523796002153 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 523796002154 Transporter associated domain; Region: CorC_HlyC; pfam03471 523796002155 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 523796002156 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 523796002157 active site 523796002158 catalytic tetrad [active] 523796002159 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 523796002160 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 523796002161 Ligand binding site; other site 523796002162 Putative Catalytic site; other site 523796002163 DXD motif; other site 523796002164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523796002165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523796002166 dimer interface [polypeptide binding]; other site 523796002167 phosphorylation site [posttranslational modification] 523796002168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796002169 ATP binding site [chemical binding]; other site 523796002170 Mg2+ binding site [ion binding]; other site 523796002171 G-X-G motif; other site 523796002172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523796002173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796002174 active site 523796002175 phosphorylation site [posttranslational modification] 523796002176 intermolecular recognition site; other site 523796002177 dimerization interface [polypeptide binding]; other site 523796002178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523796002179 DNA binding site [nucleotide binding] 523796002180 Predicted membrane protein [Function unknown]; Region: COG2259 523796002181 Electron transfer DM13; Region: DM13; pfam10517 523796002182 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 523796002183 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 523796002184 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 523796002185 active site 523796002186 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 523796002187 Ligand Binding Site [chemical binding]; other site 523796002188 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 523796002189 Glutamine amidotransferase class-I; Region: GATase; pfam00117 523796002190 glutamine binding [chemical binding]; other site 523796002191 catalytic triad [active] 523796002192 aminodeoxychorismate synthase; Provisional; Region: PRK07508 523796002193 chorismate binding enzyme; Region: Chorismate_bind; cl10555 523796002194 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 523796002195 substrate-cofactor binding pocket; other site 523796002196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796002197 catalytic residue [active] 523796002198 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 523796002199 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 523796002200 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 523796002201 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 523796002202 Sulfatase; Region: Sulfatase; pfam00884 523796002203 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 523796002204 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523796002205 ABC transporter; Region: ABC_tran_2; pfam12848 523796002206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523796002207 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 523796002208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796002209 ATP binding site [chemical binding]; other site 523796002210 putative Mg++ binding site [ion binding]; other site 523796002211 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796002212 nucleotide binding region [chemical binding]; other site 523796002213 ATP-binding site [chemical binding]; other site 523796002214 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 523796002215 HRDC domain; Region: HRDC; pfam00570 523796002216 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 523796002217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796002218 Walker A/P-loop; other site 523796002219 ATP binding site [chemical binding]; other site 523796002220 Q-loop/lid; other site 523796002221 ABC transporter signature motif; other site 523796002222 Walker B; other site 523796002223 D-loop; other site 523796002224 H-loop/switch region; other site 523796002225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796002226 dimer interface [polypeptide binding]; other site 523796002227 conserved gate region; other site 523796002228 putative PBP binding loops; other site 523796002229 ABC-ATPase subunit interface; other site 523796002230 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 523796002231 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 523796002232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523796002233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796002234 homodimer interface [polypeptide binding]; other site 523796002235 catalytic residue [active] 523796002236 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 523796002237 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 523796002238 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 523796002239 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 523796002240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796002241 putative substrate translocation pore; other site 523796002242 POT family; Region: PTR2; cl17359 523796002243 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 523796002244 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 523796002245 EamA-like transporter family; Region: EamA; pfam00892 523796002246 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 523796002247 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 523796002248 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 523796002249 Class I ribonucleotide reductase; Region: RNR_I; cd01679 523796002250 active site 523796002251 dimer interface [polypeptide binding]; other site 523796002252 catalytic residues [active] 523796002253 effector binding site; other site 523796002254 R2 peptide binding site; other site 523796002255 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 523796002256 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 523796002257 dimer interface [polypeptide binding]; other site 523796002258 putative radical transfer pathway; other site 523796002259 diiron center [ion binding]; other site 523796002260 tyrosyl radical; other site 523796002261 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796002262 ABC-ATPase subunit interface; other site 523796002263 dimer interface [polypeptide binding]; other site 523796002264 putative PBP binding regions; other site 523796002265 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 523796002266 ABC-ATPase subunit interface; other site 523796002267 dimer interface [polypeptide binding]; other site 523796002268 putative PBP binding regions; other site 523796002269 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 523796002270 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 523796002271 Walker A/P-loop; other site 523796002272 ATP binding site [chemical binding]; other site 523796002273 Q-loop/lid; other site 523796002274 ABC transporter signature motif; other site 523796002275 Walker B; other site 523796002276 D-loop; other site 523796002277 H-loop/switch region; other site 523796002278 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 523796002279 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 523796002280 putative ligand binding residues [chemical binding]; other site 523796002281 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 523796002282 FAD binding domain; Region: FAD_binding_4; pfam01565 523796002283 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 523796002284 GrpB protein; Region: GrpB; pfam04229 523796002285 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 523796002286 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 523796002287 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 523796002288 peptidase T-like protein; Region: PepT-like; TIGR01883 523796002289 metal binding site [ion binding]; metal-binding site 523796002290 dimer interface [polypeptide binding]; other site 523796002291 Uncharacterized conserved protein [Function unknown]; Region: COG3610 523796002292 Uncharacterized conserved protein [Function unknown]; Region: COG2966 523796002293 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 523796002294 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 523796002295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523796002296 metal binding site [ion binding]; metal-binding site 523796002297 active site 523796002298 I-site; other site 523796002299 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 523796002300 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 523796002301 Mg++ binding site [ion binding]; other site 523796002302 putative catalytic motif [active] 523796002303 substrate binding site [chemical binding]; other site 523796002304 Uncharacterized conserved protein [Function unknown]; Region: COG1739 523796002305 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 523796002306 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 523796002307 EDD domain protein, DegV family; Region: DegV; TIGR00762 523796002308 DEAD-like helicases superfamily; Region: DEXDc; smart00487 523796002309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796002310 ATP binding site [chemical binding]; other site 523796002311 putative Mg++ binding site [ion binding]; other site 523796002312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796002313 nucleotide binding region [chemical binding]; other site 523796002314 ATP-binding site [chemical binding]; other site 523796002315 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 523796002316 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796002317 active site 523796002318 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 523796002319 30S subunit binding site; other site 523796002320 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 523796002321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 523796002322 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 523796002323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796002324 nucleotide binding region [chemical binding]; other site 523796002325 ATP-binding site [chemical binding]; other site 523796002326 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 523796002327 SEC-C motif; Region: SEC-C; pfam02810 523796002328 peptide chain release factor 2; Provisional; Region: PRK06746 523796002329 This domain is found in peptide chain release factors; Region: PCRF; smart00937 523796002330 RF-1 domain; Region: RF-1; pfam00472 523796002331 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 523796002332 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523796002333 Surface antigen [General function prediction only]; Region: COG3942 523796002334 CHAP domain; Region: CHAP; pfam05257 523796002335 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523796002336 Zn2+ binding site [ion binding]; other site 523796002337 Mg2+ binding site [ion binding]; other site 523796002338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 523796002339 excinuclease ABC subunit B; Provisional; Region: PRK05298 523796002340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796002341 ATP binding site [chemical binding]; other site 523796002342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796002343 nucleotide binding region [chemical binding]; other site 523796002344 ATP-binding site [chemical binding]; other site 523796002345 Ultra-violet resistance protein B; Region: UvrB; pfam12344 523796002346 UvrB/uvrC motif; Region: UVR; pfam02151 523796002347 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 523796002348 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 523796002349 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 523796002350 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 523796002351 HPr kinase/phosphorylase; Provisional; Region: PRK05428 523796002352 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 523796002353 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 523796002354 Hpr binding site; other site 523796002355 active site 523796002356 homohexamer subunit interaction site [polypeptide binding]; other site 523796002357 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 523796002358 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 523796002359 putative trimer interface [polypeptide binding]; other site 523796002360 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 523796002361 putative CoA binding site [chemical binding]; other site 523796002362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523796002363 binding surface 523796002364 TPR motif; other site 523796002365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523796002366 TPR motif; other site 523796002367 binding surface 523796002368 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 523796002369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796002370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796002371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796002372 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 523796002373 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 523796002374 phosphate binding site [ion binding]; other site 523796002375 dimer interface [polypeptide binding]; other site 523796002376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 523796002377 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 523796002378 Clp protease; Region: CLP_protease; pfam00574 523796002379 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 523796002380 oligomer interface [polypeptide binding]; other site 523796002381 active site residues [active] 523796002382 malate dehydrogenase; Provisional; Region: PRK13529 523796002383 Malic enzyme, N-terminal domain; Region: malic; pfam00390 523796002384 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 523796002385 NAD(P) binding pocket [chemical binding]; other site 523796002386 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 523796002387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523796002388 NAD(P) binding site [chemical binding]; other site 523796002389 active site 523796002390 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 523796002391 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 523796002392 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 523796002393 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 523796002394 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 523796002395 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 523796002396 substrate binding site [chemical binding]; other site 523796002397 hinge regions; other site 523796002398 ADP binding site [chemical binding]; other site 523796002399 catalytic site [active] 523796002400 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 523796002401 substrate binding site [chemical binding]; other site 523796002402 dimer interface [polypeptide binding]; other site 523796002403 catalytic triad [active] 523796002404 phosphoglyceromutase; Provisional; Region: PRK05434 523796002405 enolase; Provisional; Region: eno; PRK00077 523796002406 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 523796002407 dimer interface [polypeptide binding]; other site 523796002408 metal binding site [ion binding]; metal-binding site 523796002409 substrate binding pocket [chemical binding]; other site 523796002410 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 523796002411 Esterase/lipase [General function prediction only]; Region: COG1647 523796002412 ribonuclease R; Region: RNase_R; TIGR02063 523796002413 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 523796002414 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 523796002415 RNB domain; Region: RNB; pfam00773 523796002416 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 523796002417 RNA binding site [nucleotide binding]; other site 523796002418 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 523796002419 SmpB-tmRNA interface; other site 523796002420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796002421 Coenzyme A binding pocket [chemical binding]; other site 523796002422 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 523796002423 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 523796002424 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 523796002425 Staphylococcal nuclease homologues; Region: SNc; smart00318 523796002426 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 523796002427 Catalytic site; other site 523796002428 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 523796002429 DNA-binding site [nucleotide binding]; DNA binding site 523796002430 RNA-binding motif; other site 523796002431 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 523796002432 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 523796002433 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523796002434 catalytic core [active] 523796002435 Lysine efflux permease [General function prediction only]; Region: COG1279 523796002436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 523796002437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 523796002438 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 523796002439 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 523796002440 active site 523796002441 catalytic residue [active] 523796002442 dimer interface [polypeptide binding]; other site 523796002443 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 523796002444 FMN binding site [chemical binding]; other site 523796002445 dimer interface [polypeptide binding]; other site 523796002446 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523796002447 catalytic residues [active] 523796002448 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 523796002449 putative ArsC-like catalytic residues; other site 523796002450 putative TRX-like catalytic residues [active] 523796002451 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 523796002452 lipoyl attachment site [posttranslational modification]; other site 523796002453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 523796002454 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 523796002455 putative active site [active] 523796002456 putative metal binding site [ion binding]; other site 523796002457 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523796002458 catalytic residues [active] 523796002459 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 523796002460 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 523796002461 Walker A/P-loop; other site 523796002462 ATP binding site [chemical binding]; other site 523796002463 Q-loop/lid; other site 523796002464 ABC transporter signature motif; other site 523796002465 Walker B; other site 523796002466 D-loop; other site 523796002467 H-loop/switch region; other site 523796002468 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 523796002469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796002470 dimer interface [polypeptide binding]; other site 523796002471 conserved gate region; other site 523796002472 putative PBP binding loops; other site 523796002473 ABC-ATPase subunit interface; other site 523796002474 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 523796002475 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 523796002476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 523796002477 Predicted membrane protein [Function unknown]; Region: COG2035 523796002478 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 523796002479 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 523796002480 Walker A/P-loop; other site 523796002481 ATP binding site [chemical binding]; other site 523796002482 Q-loop/lid; other site 523796002483 ABC transporter signature motif; other site 523796002484 Walker B; other site 523796002485 D-loop; other site 523796002486 H-loop/switch region; other site 523796002487 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 523796002488 FeS assembly protein SufD; Region: sufD; TIGR01981 523796002489 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 523796002490 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523796002491 catalytic residue [active] 523796002492 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 523796002493 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 523796002494 trimerization site [polypeptide binding]; other site 523796002495 active site 523796002496 FeS assembly protein SufB; Region: sufB; TIGR01980 523796002497 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 523796002498 Domain of unknown function DUF21; Region: DUF21; pfam01595 523796002499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 523796002500 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 523796002501 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 523796002502 FMN binding site [chemical binding]; other site 523796002503 substrate binding site [chemical binding]; other site 523796002504 putative catalytic residue [active] 523796002505 Uncharacterized conserved protein [Function unknown]; Region: COG1801 523796002506 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 523796002507 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 523796002508 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 523796002509 active site 523796002510 metal binding site [ion binding]; metal-binding site 523796002511 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 523796002512 lipoyl synthase; Provisional; Region: PRK05481 523796002513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796002514 FeS/SAM binding site; other site 523796002515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 523796002516 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 523796002517 Uncharacterized conserved protein [Function unknown]; Region: COG2445 523796002518 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 523796002519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796002520 active site 523796002521 motif I; other site 523796002522 motif II; other site 523796002523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796002524 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 523796002525 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 523796002526 dimerization interface [polypeptide binding]; other site 523796002527 ligand binding site [chemical binding]; other site 523796002528 NADP binding site [chemical binding]; other site 523796002529 catalytic site [active] 523796002530 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 523796002531 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 523796002532 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 523796002533 acyl-activating enzyme (AAE) consensus motif; other site 523796002534 AMP binding site [chemical binding]; other site 523796002535 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 523796002536 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 523796002537 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 523796002538 DltD N-terminal region; Region: DltD_N; pfam04915 523796002539 DltD central region; Region: DltD_M; pfam04918 523796002540 DltD C-terminal region; Region: DltD_C; pfam04914 523796002541 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 523796002542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 523796002543 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 523796002544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796002545 hypothetical protein; Provisional; Region: PRK13669 523796002546 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 523796002547 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 523796002548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796002549 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 523796002550 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 523796002551 interface (dimer of trimers) [polypeptide binding]; other site 523796002552 Substrate-binding/catalytic site; other site 523796002553 Zn-binding sites [ion binding]; other site 523796002554 Predicted permease [General function prediction only]; Region: COG2056 523796002555 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 523796002556 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 523796002557 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 523796002558 CoenzymeA binding site [chemical binding]; other site 523796002559 subunit interaction site [polypeptide binding]; other site 523796002560 PHB binding site; other site 523796002561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 523796002562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796002563 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 523796002564 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 523796002565 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 523796002566 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 523796002567 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523796002568 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 523796002569 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 523796002570 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 523796002571 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523796002572 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 523796002573 Kinase associated protein B; Region: KapB; pfam08810 523796002574 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 523796002575 active site 523796002576 general stress protein 13; Validated; Region: PRK08059 523796002577 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 523796002578 RNA binding site [nucleotide binding]; other site 523796002579 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 523796002580 putative active site [active] 523796002581 putative FMN binding site [chemical binding]; other site 523796002582 putative substrate binding site [chemical binding]; other site 523796002583 putative catalytic residue [active] 523796002584 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523796002585 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 523796002586 inhibitor-cofactor binding pocket; inhibition site 523796002587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796002588 catalytic residue [active] 523796002589 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 523796002590 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 523796002591 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 523796002592 NAD(P) binding site [chemical binding]; other site 523796002593 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 523796002594 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 523796002595 active site 523796002596 catalytic site [active] 523796002597 metal binding site [ion binding]; metal-binding site 523796002598 argininosuccinate lyase; Provisional; Region: PRK00855 523796002599 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 523796002600 active sites [active] 523796002601 tetramer interface [polypeptide binding]; other site 523796002602 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 523796002603 ANP binding site [chemical binding]; other site 523796002604 Substrate Binding Site II [chemical binding]; other site 523796002605 Substrate Binding Site I [chemical binding]; other site 523796002606 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 523796002607 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 523796002608 active site 523796002609 dimer interface [polypeptide binding]; other site 523796002610 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 523796002611 dimer interface [polypeptide binding]; other site 523796002612 active site 523796002613 Uncharacterized conserved protein [Function unknown]; Region: COG0398 523796002614 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 523796002615 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 523796002616 Catalytic site [active] 523796002617 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 523796002618 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 523796002619 Catalytic site [active] 523796002620 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 523796002621 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 523796002622 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 523796002623 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 523796002624 Part of AAA domain; Region: AAA_19; pfam13245 523796002625 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 523796002626 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 523796002627 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 523796002628 hypothetical protein; Provisional; Region: PRK13673 523796002629 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 523796002630 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 523796002631 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 523796002632 Int/Topo IB signature motif; other site 523796002633 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 523796002634 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 523796002635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523796002636 DNA binding residues [nucleotide binding] 523796002637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796002638 non-specific DNA binding site [nucleotide binding]; other site 523796002639 salt bridge; other site 523796002640 sequence-specific DNA binding site [nucleotide binding]; other site 523796002641 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 523796002642 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 523796002643 G1 box; other site 523796002644 putative GEF interaction site [polypeptide binding]; other site 523796002645 GTP/Mg2+ binding site [chemical binding]; other site 523796002646 Switch I region; other site 523796002647 G2 box; other site 523796002648 G3 box; other site 523796002649 Switch II region; other site 523796002650 G4 box; other site 523796002651 G5 box; other site 523796002652 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 523796002653 Elongation Factor G, domain II; Region: EFG_II; pfam14492 523796002654 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 523796002655 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 523796002656 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 523796002657 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523796002658 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523796002659 catalytic residue [active] 523796002660 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 523796002661 NlpC/P60 family; Region: NLPC_P60; pfam00877 523796002662 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 523796002663 Haemolysin-III related; Region: HlyIII; cl03831 523796002664 AAA-like domain; Region: AAA_10; pfam12846 523796002665 TcpE family; Region: TcpE; pfam12648 523796002666 Antirestriction protein (ArdA); Region: ArdA; pfam07275 523796002667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796002668 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 523796002669 non-specific DNA binding site [nucleotide binding]; other site 523796002670 salt bridge; other site 523796002671 sequence-specific DNA binding site [nucleotide binding]; other site 523796002672 Replication initiation factor; Region: Rep_trans; pfam02486 523796002673 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 523796002674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796002675 Walker A motif; other site 523796002676 ATP binding site [chemical binding]; other site 523796002677 Walker B motif; other site 523796002678 arginine finger; other site 523796002679 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 523796002680 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 523796002681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 523796002682 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 523796002683 coenzyme A disulfide reductase; Provisional; Region: PRK13512 523796002684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796002685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796002686 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 523796002687 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 523796002688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796002689 active site 523796002690 motif I; other site 523796002691 motif II; other site 523796002692 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 523796002693 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 523796002694 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 523796002695 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 523796002696 catalytic triad [active] 523796002697 catalytic triad [active] 523796002698 oxyanion hole [active] 523796002699 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 523796002700 Clp amino terminal domain; Region: Clp_N; pfam02861 523796002701 Clp amino terminal domain; Region: Clp_N; pfam02861 523796002702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796002703 Walker A motif; other site 523796002704 ATP binding site [chemical binding]; other site 523796002705 Walker B motif; other site 523796002706 arginine finger; other site 523796002707 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 523796002708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796002709 Walker A motif; other site 523796002710 ATP binding site [chemical binding]; other site 523796002711 Walker B motif; other site 523796002712 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 523796002713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523796002714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523796002715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 523796002716 dimerization interface [polypeptide binding]; other site 523796002717 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 523796002718 substrate binding site [chemical binding]; other site 523796002719 MAP domain; Region: MAP; pfam03642 523796002720 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 523796002721 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 523796002722 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 523796002723 dimer interface [polypeptide binding]; other site 523796002724 active site 523796002725 CoA binding pocket [chemical binding]; other site 523796002726 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 523796002727 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 523796002728 dimer interface [polypeptide binding]; other site 523796002729 active site 523796002730 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 523796002731 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523796002732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796002733 dimer interface [polypeptide binding]; other site 523796002734 conserved gate region; other site 523796002735 putative PBP binding loops; other site 523796002736 ABC-ATPase subunit interface; other site 523796002737 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 523796002738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796002739 dimer interface [polypeptide binding]; other site 523796002740 conserved gate region; other site 523796002741 putative PBP binding loops; other site 523796002742 ABC-ATPase subunit interface; other site 523796002743 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 523796002744 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523796002745 Walker A/P-loop; other site 523796002746 ATP binding site [chemical binding]; other site 523796002747 Q-loop/lid; other site 523796002748 ABC transporter signature motif; other site 523796002749 Walker B; other site 523796002750 D-loop; other site 523796002751 H-loop/switch region; other site 523796002752 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523796002753 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 523796002754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523796002755 Walker A/P-loop; other site 523796002756 ATP binding site [chemical binding]; other site 523796002757 Q-loop/lid; other site 523796002758 ABC transporter signature motif; other site 523796002759 Walker B; other site 523796002760 D-loop; other site 523796002761 H-loop/switch region; other site 523796002762 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523796002763 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 523796002764 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 523796002765 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 523796002766 peptide binding site [polypeptide binding]; other site 523796002767 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523796002768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796002769 dimer interface [polypeptide binding]; other site 523796002770 conserved gate region; other site 523796002771 putative PBP binding loops; other site 523796002772 ABC-ATPase subunit interface; other site 523796002773 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 523796002774 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 523796002775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796002776 dimer interface [polypeptide binding]; other site 523796002777 conserved gate region; other site 523796002778 putative PBP binding loops; other site 523796002779 ABC-ATPase subunit interface; other site 523796002780 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 523796002781 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523796002782 Walker A/P-loop; other site 523796002783 ATP binding site [chemical binding]; other site 523796002784 Q-loop/lid; other site 523796002785 ABC transporter signature motif; other site 523796002786 Walker B; other site 523796002787 D-loop; other site 523796002788 H-loop/switch region; other site 523796002789 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523796002790 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 523796002791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523796002792 Walker A/P-loop; other site 523796002793 ATP binding site [chemical binding]; other site 523796002794 Q-loop/lid; other site 523796002795 ABC transporter signature motif; other site 523796002796 Walker B; other site 523796002797 D-loop; other site 523796002798 H-loop/switch region; other site 523796002799 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523796002800 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 523796002801 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 523796002802 peptide binding site [polypeptide binding]; other site 523796002803 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 523796002804 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 523796002805 active site 523796002806 HIGH motif; other site 523796002807 dimer interface [polypeptide binding]; other site 523796002808 KMSKS motif; other site 523796002809 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 523796002810 putative catalytic residues [active] 523796002811 thiol/disulfide switch; other site 523796002812 adaptor protein; Provisional; Region: PRK02315 523796002813 Competence protein CoiA-like family; Region: CoiA; cl11541 523796002814 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 523796002815 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 523796002816 active site 523796002817 Zn binding site [ion binding]; other site 523796002818 Thioredoxin; Region: Thioredoxin_5; pfam13743 523796002819 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 523796002820 apolar tunnel; other site 523796002821 heme binding site [chemical binding]; other site 523796002822 dimerization interface [polypeptide binding]; other site 523796002823 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 523796002824 putative active site [active] 523796002825 putative metal binding residues [ion binding]; other site 523796002826 signature motif; other site 523796002827 putative triphosphate binding site [ion binding]; other site 523796002828 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 523796002829 synthetase active site [active] 523796002830 NTP binding site [chemical binding]; other site 523796002831 metal binding site [ion binding]; metal-binding site 523796002832 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 523796002833 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 523796002834 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523796002835 active site 523796002836 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 523796002837 MgtE intracellular N domain; Region: MgtE_N; smart00924 523796002838 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 523796002839 Divalent cation transporter; Region: MgtE; pfam01769 523796002840 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 523796002841 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 523796002842 TrkA-N domain; Region: TrkA_N; pfam02254 523796002843 TrkA-C domain; Region: TrkA_C; pfam02080 523796002844 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 523796002845 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 523796002846 NAD binding site [chemical binding]; other site 523796002847 homotetramer interface [polypeptide binding]; other site 523796002848 homodimer interface [polypeptide binding]; other site 523796002849 substrate binding site [chemical binding]; other site 523796002850 active site 523796002851 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 523796002852 Domain of unknown function DUF20; Region: UPF0118; pfam01594 523796002853 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 523796002854 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 523796002855 Putative esterase; Region: Esterase; pfam00756 523796002856 hypothetical protein; Provisional; Region: PRK13679 523796002857 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 523796002858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796002859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796002860 putative substrate translocation pore; other site 523796002861 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 523796002862 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 523796002863 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523796002864 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 523796002865 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523796002866 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523796002867 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523796002868 YueH-like protein; Region: YueH; pfam14166 523796002869 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 523796002870 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 523796002871 G1 box; other site 523796002872 putative GEF interaction site [polypeptide binding]; other site 523796002873 GTP/Mg2+ binding site [chemical binding]; other site 523796002874 Switch I region; other site 523796002875 G2 box; other site 523796002876 G3 box; other site 523796002877 Switch II region; other site 523796002878 G4 box; other site 523796002879 G5 box; other site 523796002880 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 523796002881 Elongation Factor G, domain II; Region: EFG_II; pfam14492 523796002882 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 523796002883 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 523796002884 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 523796002885 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 523796002886 protein binding site [polypeptide binding]; other site 523796002887 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 523796002888 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 523796002889 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 523796002890 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 523796002891 active site 523796002892 metal binding site [ion binding]; metal-binding site 523796002893 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 523796002894 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 523796002895 IDEAL domain; Region: IDEAL; pfam08858 523796002896 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 523796002897 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 523796002898 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 523796002899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 523796002900 CAAX protease self-immunity; Region: Abi; pfam02517 523796002901 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 523796002902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 523796002903 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 523796002904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 523796002905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796002906 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 523796002907 Walker A/P-loop; other site 523796002908 ATP binding site [chemical binding]; other site 523796002909 Q-loop/lid; other site 523796002910 ABC transporter signature motif; other site 523796002911 Walker B; other site 523796002912 D-loop; other site 523796002913 H-loop/switch region; other site 523796002914 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523796002915 Predicted membrane protein [Function unknown]; Region: COG2259 523796002916 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 523796002917 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 523796002918 siderophore binding site; other site 523796002919 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 523796002920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796002921 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 523796002922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 523796002923 Coenzyme A binding pocket [chemical binding]; other site 523796002924 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 523796002925 UbiA prenyltransferase family; Region: UbiA; pfam01040 523796002926 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 523796002927 isochorismate synthases; Region: isochor_syn; TIGR00543 523796002928 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 523796002929 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 523796002930 dimer interface [polypeptide binding]; other site 523796002931 tetramer interface [polypeptide binding]; other site 523796002932 PYR/PP interface [polypeptide binding]; other site 523796002933 TPP binding site [chemical binding]; other site 523796002934 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 523796002935 TPP-binding site; other site 523796002936 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 523796002937 Putative lysophospholipase; Region: Hydrolase_4; cl19140 523796002938 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 523796002939 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 523796002940 substrate binding site [chemical binding]; other site 523796002941 oxyanion hole (OAH) forming residues; other site 523796002942 trimer interface [polypeptide binding]; other site 523796002943 Staphostatin B; Region: Staphostatin_B; pfam09023 523796002944 Staphopain proregion; Region: Staphopain_pro; pfam14731 523796002945 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 523796002946 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 523796002947 aminotransferase A; Validated; Region: PRK07683 523796002948 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523796002949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796002950 homodimer interface [polypeptide binding]; other site 523796002951 catalytic residue [active] 523796002952 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 523796002953 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796002954 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 523796002955 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 523796002956 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 523796002957 amidase catalytic site [active] 523796002958 Zn binding residues [ion binding]; other site 523796002959 substrate binding site [chemical binding]; other site 523796002960 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 523796002961 Lysozyme subfamily 2; Region: LYZ2; smart00047 523796002962 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 523796002963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796002964 Coenzyme A binding pocket [chemical binding]; other site 523796002965 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 523796002966 Transcriptional regulator [Transcription]; Region: LytR; COG1316 523796002967 Beta-lactamase; Region: Beta-lactamase; pfam00144 523796002968 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 523796002969 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 523796002970 Subunit I/III interface [polypeptide binding]; other site 523796002971 Subunit III/IV interface [polypeptide binding]; other site 523796002972 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 523796002973 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 523796002974 D-pathway; other site 523796002975 Putative ubiquinol binding site [chemical binding]; other site 523796002976 Low-spin heme (heme b) binding site [chemical binding]; other site 523796002977 Putative water exit pathway; other site 523796002978 Binuclear center (heme o3/CuB) [ion binding]; other site 523796002979 K-pathway; other site 523796002980 Putative proton exit pathway; other site 523796002981 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 523796002982 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 523796002983 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 523796002984 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 523796002985 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 523796002986 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 523796002987 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 523796002988 homodimer interface [polypeptide binding]; other site 523796002989 NADP binding site [chemical binding]; other site 523796002990 substrate binding site [chemical binding]; other site 523796002991 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 523796002992 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 523796002993 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523796002994 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 523796002995 ATP binding site [chemical binding]; other site 523796002996 active site 523796002997 substrate binding site [chemical binding]; other site 523796002998 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 523796002999 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 523796003000 putative active site [active] 523796003001 catalytic triad [active] 523796003002 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 523796003003 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 523796003004 dimerization interface [polypeptide binding]; other site 523796003005 ATP binding site [chemical binding]; other site 523796003006 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 523796003007 dimerization interface [polypeptide binding]; other site 523796003008 ATP binding site [chemical binding]; other site 523796003009 amidophosphoribosyltransferase; Provisional; Region: PRK07272 523796003010 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 523796003011 active site 523796003012 tetramer interface [polypeptide binding]; other site 523796003013 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796003014 active site 523796003015 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 523796003016 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 523796003017 dimerization interface [polypeptide binding]; other site 523796003018 putative ATP binding site [chemical binding]; other site 523796003019 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 523796003020 active site 523796003021 substrate binding site [chemical binding]; other site 523796003022 cosubstrate binding site; other site 523796003023 catalytic site [active] 523796003024 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 523796003025 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 523796003026 purine monophosphate binding site [chemical binding]; other site 523796003027 dimer interface [polypeptide binding]; other site 523796003028 putative catalytic residues [active] 523796003029 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 523796003030 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 523796003031 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 523796003032 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 523796003033 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 523796003034 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 523796003035 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 523796003036 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 523796003037 Walker A/P-loop; other site 523796003038 ATP binding site [chemical binding]; other site 523796003039 Q-loop/lid; other site 523796003040 ABC transporter signature motif; other site 523796003041 Walker B; other site 523796003042 D-loop; other site 523796003043 H-loop/switch region; other site 523796003044 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 523796003045 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 523796003046 Walker A/P-loop; other site 523796003047 ATP binding site [chemical binding]; other site 523796003048 Q-loop/lid; other site 523796003049 ABC transporter signature motif; other site 523796003050 Walker B; other site 523796003051 D-loop; other site 523796003052 H-loop/switch region; other site 523796003053 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 523796003054 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 523796003055 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 523796003056 putative RNA binding site [nucleotide binding]; other site 523796003057 Methyltransferase domain; Region: Methyltransf_26; pfam13659 523796003058 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 523796003059 dimerization domain swap beta strand [polypeptide binding]; other site 523796003060 regulatory protein interface [polypeptide binding]; other site 523796003061 active site 523796003062 regulatory phosphorylation site [posttranslational modification]; other site 523796003063 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 523796003064 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 523796003065 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 523796003066 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 523796003067 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 523796003068 catalytic residues [active] 523796003069 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 523796003070 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 523796003071 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 523796003072 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 523796003073 TrkA-N domain; Region: TrkA_N; pfam02254 523796003074 TrkA-C domain; Region: TrkA_C; pfam02080 523796003075 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 523796003076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 523796003077 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 523796003078 hypothetical protein; Provisional; Region: PRK13667 523796003079 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 523796003080 active site 523796003081 catalytic residues [active] 523796003082 metal binding site [ion binding]; metal-binding site 523796003083 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 523796003084 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 523796003085 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 523796003086 TPP-binding site [chemical binding]; other site 523796003087 tetramer interface [polypeptide binding]; other site 523796003088 heterodimer interface [polypeptide binding]; other site 523796003089 phosphorylation loop region [posttranslational modification] 523796003090 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 523796003091 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 523796003092 alpha subunit interface [polypeptide binding]; other site 523796003093 TPP binding site [chemical binding]; other site 523796003094 heterodimer interface [polypeptide binding]; other site 523796003095 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523796003096 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 523796003097 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523796003098 E3 interaction surface; other site 523796003099 lipoyl attachment site [posttranslational modification]; other site 523796003100 e3 binding domain; Region: E3_binding; pfam02817 523796003101 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 523796003102 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 523796003103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796003104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796003105 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 523796003106 hypothetical protein; Provisional; Region: PRK04387 523796003107 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523796003108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796003109 non-specific DNA binding site [nucleotide binding]; other site 523796003110 salt bridge; other site 523796003111 sequence-specific DNA binding site [nucleotide binding]; other site 523796003112 Cupin domain; Region: Cupin_2; pfam07883 523796003113 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 523796003114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796003115 Walker A/P-loop; other site 523796003116 ATP binding site [chemical binding]; other site 523796003117 Q-loop/lid; other site 523796003118 ABC transporter signature motif; other site 523796003119 Walker B; other site 523796003120 D-loop; other site 523796003121 H-loop/switch region; other site 523796003122 TOBE domain; Region: TOBE_2; pfam08402 523796003123 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 523796003124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796003125 dimer interface [polypeptide binding]; other site 523796003126 conserved gate region; other site 523796003127 putative PBP binding loops; other site 523796003128 ABC-ATPase subunit interface; other site 523796003129 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 523796003130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796003131 dimer interface [polypeptide binding]; other site 523796003132 conserved gate region; other site 523796003133 putative PBP binding loops; other site 523796003134 ABC-ATPase subunit interface; other site 523796003135 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 523796003136 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 523796003137 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 523796003138 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 523796003139 manganese transport protein MntH; Reviewed; Region: PRK00701 523796003140 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 523796003141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 523796003142 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 523796003143 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 523796003144 active site 523796003145 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 523796003146 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 523796003147 G1 box; other site 523796003148 putative GEF interaction site [polypeptide binding]; other site 523796003149 GTP/Mg2+ binding site [chemical binding]; other site 523796003150 Switch I region; other site 523796003151 G2 box; other site 523796003152 G3 box; other site 523796003153 Switch II region; other site 523796003154 G4 box; other site 523796003155 G5 box; other site 523796003156 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 523796003157 Elongation Factor G, domain II; Region: EFG_II; pfam14492 523796003158 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 523796003159 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 523796003160 hypothetical protein; Provisional; Region: PRK13666 523796003161 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 523796003162 pyruvate carboxylase; Reviewed; Region: PRK12999 523796003163 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523796003164 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 523796003165 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 523796003166 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 523796003167 active site 523796003168 catalytic residues [active] 523796003169 metal binding site [ion binding]; metal-binding site 523796003170 homodimer binding site [polypeptide binding]; other site 523796003171 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 523796003172 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 523796003173 carboxyltransferase (CT) interaction site; other site 523796003174 biotinylation site [posttranslational modification]; other site 523796003175 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 523796003176 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 523796003177 putative active site [active] 523796003178 Predicted membrane protein [Function unknown]; Region: COG2322 523796003179 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 523796003180 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 523796003181 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 523796003182 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 523796003183 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 523796003184 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 523796003185 putative active site [active] 523796003186 catalytic site [active] 523796003187 putative metal binding site [ion binding]; other site 523796003188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 523796003189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796003190 S-adenosylmethionine binding site [chemical binding]; other site 523796003191 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 523796003192 active site 523796003193 (T/H)XGH motif; other site 523796003194 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 523796003195 hypothetical protein; Provisional; Region: PRK13670 523796003196 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 523796003197 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 523796003198 heme uptake protein IsdB; Region: IsdB; TIGR03657 523796003199 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 523796003200 NEAr Transporter domain; Region: NEAT; smart00725 523796003201 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 523796003202 heme-binding site [chemical binding]; other site 523796003203 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 523796003204 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 523796003205 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 523796003206 heme-binding site [chemical binding]; other site 523796003207 heme uptake protein IsdC; Region: IsdC; TIGR03656 523796003208 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 523796003209 heme-binding site [chemical binding]; other site 523796003210 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 523796003211 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 523796003212 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 523796003213 intersubunit interface [polypeptide binding]; other site 523796003214 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796003215 ABC-ATPase subunit interface; other site 523796003216 dimer interface [polypeptide binding]; other site 523796003217 putative PBP binding regions; other site 523796003218 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 523796003219 active site 523796003220 catalytic site [active] 523796003221 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 523796003222 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 523796003223 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 523796003224 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 523796003225 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 523796003226 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 523796003227 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 523796003228 dimer interface [polypeptide binding]; other site 523796003229 motif 1; other site 523796003230 active site 523796003231 motif 2; other site 523796003232 motif 3; other site 523796003233 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 523796003234 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 523796003235 putative tRNA-binding site [nucleotide binding]; other site 523796003236 B3/4 domain; Region: B3_4; pfam03483 523796003237 tRNA synthetase B5 domain; Region: B5; smart00874 523796003238 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 523796003239 dimer interface [polypeptide binding]; other site 523796003240 motif 1; other site 523796003241 motif 3; other site 523796003242 motif 2; other site 523796003243 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 523796003244 ribonuclease HIII; Provisional; Region: PRK00996 523796003245 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 523796003246 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 523796003247 RNA/DNA hybrid binding site [nucleotide binding]; other site 523796003248 active site 523796003249 Cell division protein ZapA; Region: ZapA; cl01146 523796003250 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 523796003251 hypothetical protein; Provisional; Region: PRK08609 523796003252 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 523796003253 active site 523796003254 primer binding site [nucleotide binding]; other site 523796003255 NTP binding site [chemical binding]; other site 523796003256 metal binding triad [ion binding]; metal-binding site 523796003257 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 523796003258 active site 523796003259 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 523796003260 MutS domain III; Region: MutS_III; pfam05192 523796003261 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 523796003262 Walker A/P-loop; other site 523796003263 ATP binding site [chemical binding]; other site 523796003264 Q-loop/lid; other site 523796003265 ABC transporter signature motif; other site 523796003266 Walker B; other site 523796003267 D-loop; other site 523796003268 H-loop/switch region; other site 523796003269 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 523796003270 Smr domain; Region: Smr; pfam01713 523796003271 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523796003272 catalytic residues [active] 523796003273 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 523796003274 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 523796003275 GIY-YIG motif/motif A; other site 523796003276 active site 523796003277 catalytic site [active] 523796003278 putative DNA binding site [nucleotide binding]; other site 523796003279 metal binding site [ion binding]; metal-binding site 523796003280 UvrB/uvrC motif; Region: UVR; pfam02151 523796003281 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 523796003282 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 523796003283 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 523796003284 putative Iron-sulfur protein interface [polypeptide binding]; other site 523796003285 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 523796003286 proximal heme binding site [chemical binding]; other site 523796003287 distal heme binding site [chemical binding]; other site 523796003288 putative dimer interface [polypeptide binding]; other site 523796003289 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 523796003290 L-aspartate oxidase; Provisional; Region: PRK06175 523796003291 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 523796003292 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 523796003293 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 523796003294 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 523796003295 glutamate racemase; Provisional; Region: PRK00865 523796003296 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 523796003297 active site 523796003298 dimerization interface [polypeptide binding]; other site 523796003299 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 523796003300 active site 523796003301 metal binding site [ion binding]; metal-binding site 523796003302 homotetramer interface [polypeptide binding]; other site 523796003303 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 523796003304 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 523796003305 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 523796003306 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 523796003307 beta-channel forming cytolysin; Region: hlyII; TIGR01002 523796003308 superantigen-like protein; Reviewed; Region: PRK13350 523796003309 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796003310 superantigen-like protein; Reviewed; Region: PRK13349 523796003311 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796003312 superantigen-like protein; Reviewed; Region: PRK13043 523796003313 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796003314 ornithine carbamoyltransferase; Provisional; Region: PRK04284 523796003315 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 523796003316 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 523796003317 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 523796003318 putative substrate binding site [chemical binding]; other site 523796003319 nucleotide binding site [chemical binding]; other site 523796003320 nucleotide binding site [chemical binding]; other site 523796003321 homodimer interface [polypeptide binding]; other site 523796003322 Predicted membrane protein [Function unknown]; Region: COG1288 523796003323 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 523796003324 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 523796003325 gating phenylalanine in ion channel; other site 523796003326 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 523796003327 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 523796003328 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 523796003329 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 523796003330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796003331 motif II; other site 523796003332 hypothetical protein; Provisional; Region: PRK13688 523796003333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 523796003334 Coenzyme A binding pocket [chemical binding]; other site 523796003335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 523796003336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 523796003337 MraZ protein; Region: MraZ; pfam02381 523796003338 MraZ protein; Region: MraZ; pfam02381 523796003339 MraW methylase family; Region: Methyltransf_5; pfam01795 523796003340 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 523796003341 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 523796003342 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 523796003343 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 523796003344 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 523796003345 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 523796003346 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 523796003347 Mg++ binding site [ion binding]; other site 523796003348 putative catalytic motif [active] 523796003349 putative substrate binding site [chemical binding]; other site 523796003350 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 523796003351 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 523796003352 NAD binding site [chemical binding]; other site 523796003353 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523796003354 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523796003355 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 523796003356 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 523796003357 Cell division protein FtsQ; Region: FtsQ; pfam03799 523796003358 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 523796003359 Cell division protein FtsA; Region: FtsA; smart00842 523796003360 Cell division protein FtsA; Region: FtsA; pfam14450 523796003361 cell division protein FtsZ; Validated; Region: PRK09330 523796003362 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 523796003363 nucleotide binding site [chemical binding]; other site 523796003364 SulA interaction site; other site 523796003365 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 523796003366 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 523796003367 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523796003368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 523796003369 Predicted integral membrane protein [Function unknown]; Region: COG0762 523796003370 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 523796003371 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523796003372 RNA binding surface [nucleotide binding]; other site 523796003373 DivIVA protein; Region: DivIVA; pfam05103 523796003374 DivIVA domain; Region: DivI1A_domain; TIGR03544 523796003375 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 523796003376 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 523796003377 active site 523796003378 HIGH motif; other site 523796003379 KMSKS motif; other site 523796003380 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 523796003381 tRNA binding surface [nucleotide binding]; other site 523796003382 anticodon binding site; other site 523796003383 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 523796003384 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 523796003385 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 523796003386 active site 523796003387 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 523796003388 lipoprotein signal peptidase; Provisional; Region: PRK14787 523796003389 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 523796003390 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523796003391 RNA binding surface [nucleotide binding]; other site 523796003392 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523796003393 active site 523796003394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796003395 active site 523796003396 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 523796003397 Sulfate transporter family; Region: Sulfate_transp; cl19250 523796003398 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 523796003399 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 523796003400 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 523796003401 dihydroorotase; Validated; Region: pyrC; PRK09357 523796003402 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523796003403 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 523796003404 active site 523796003405 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 523796003406 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 523796003407 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 523796003408 catalytic site [active] 523796003409 subunit interface [polypeptide binding]; other site 523796003410 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 523796003411 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523796003412 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 523796003413 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 523796003414 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523796003415 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523796003416 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 523796003417 IMP binding site; other site 523796003418 dimer interface [polypeptide binding]; other site 523796003419 interdomain contacts; other site 523796003420 partial ornithine binding site; other site 523796003421 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 523796003422 active site 523796003423 dimer interface [polypeptide binding]; other site 523796003424 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796003425 active site 523796003426 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 523796003427 dimer interface [polypeptide binding]; other site 523796003428 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 523796003429 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 523796003430 Domain of unknown function (DUF814); Region: DUF814; pfam05670 523796003431 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 523796003432 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 523796003433 catalytic site [active] 523796003434 G-X2-G-X-G-K; other site 523796003435 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 523796003436 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 523796003437 Flavoprotein; Region: Flavoprotein; cl19190 523796003438 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 523796003439 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 523796003440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796003441 ATP binding site [chemical binding]; other site 523796003442 putative Mg++ binding site [ion binding]; other site 523796003443 helicase superfamily c-terminal domain; Region: HELICc; smart00490 523796003444 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 523796003445 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 523796003446 active site 523796003447 catalytic residues [active] 523796003448 metal binding site [ion binding]; metal-binding site 523796003449 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 523796003450 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 523796003451 putative active site [active] 523796003452 substrate binding site [chemical binding]; other site 523796003453 putative cosubstrate binding site; other site 523796003454 catalytic site [active] 523796003455 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 523796003456 substrate binding site [chemical binding]; other site 523796003457 16S rRNA methyltransferase B; Provisional; Region: PRK14902 523796003458 NusB family; Region: NusB; pfam01029 523796003459 putative RNA binding site [nucleotide binding]; other site 523796003460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796003461 S-adenosylmethionine binding site [chemical binding]; other site 523796003462 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 523796003463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796003464 FeS/SAM binding site; other site 523796003465 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 523796003466 active site 523796003467 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 523796003468 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 523796003469 active site 523796003470 ATP binding site [chemical binding]; other site 523796003471 substrate binding site [chemical binding]; other site 523796003472 activation loop (A-loop); other site 523796003473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 523796003474 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 523796003475 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 523796003476 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 523796003477 Predicted GTPases [General function prediction only]; Region: COG1162 523796003478 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 523796003479 RNA binding site [nucleotide binding]; other site 523796003480 homodimer interface [polypeptide binding]; other site 523796003481 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 523796003482 GTPase/Zn-binding domain interface [polypeptide binding]; other site 523796003483 GTP/Mg2+ binding site [chemical binding]; other site 523796003484 G4 box; other site 523796003485 G5 box; other site 523796003486 G1 box; other site 523796003487 Switch I region; other site 523796003488 G2 box; other site 523796003489 G3 box; other site 523796003490 Switch II region; other site 523796003491 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 523796003492 substrate binding site [chemical binding]; other site 523796003493 hexamer interface [polypeptide binding]; other site 523796003494 metal binding site [ion binding]; metal-binding site 523796003495 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 523796003496 Thiamine pyrophosphokinase; Region: TPK; cd07995 523796003497 active site 523796003498 dimerization interface [polypeptide binding]; other site 523796003499 thiamine binding site [chemical binding]; other site 523796003500 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 523796003501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 523796003502 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 523796003503 DAK2 domain; Region: Dak2; pfam02734 523796003504 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 523796003505 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 523796003506 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 523796003507 generic binding surface II; other site 523796003508 ssDNA binding site; other site 523796003509 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796003510 ATP binding site [chemical binding]; other site 523796003511 putative Mg++ binding site [ion binding]; other site 523796003512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796003513 nucleotide binding region [chemical binding]; other site 523796003514 ATP-binding site [chemical binding]; other site 523796003515 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 523796003516 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 523796003517 active site 2 [active] 523796003518 active site 1 [active] 523796003519 putative phosphate acyltransferase; Provisional; Region: PRK05331 523796003520 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 523796003521 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 523796003522 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 523796003523 NAD(P) binding site [chemical binding]; other site 523796003524 homotetramer interface [polypeptide binding]; other site 523796003525 homodimer interface [polypeptide binding]; other site 523796003526 active site 523796003527 acyl carrier protein; Provisional; Region: acpP; PRK00982 523796003528 ribonuclease III; Reviewed; Region: rnc; PRK00102 523796003529 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 523796003530 dimerization interface [polypeptide binding]; other site 523796003531 active site 523796003532 metal binding site [ion binding]; metal-binding site 523796003533 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 523796003534 dsRNA binding site [nucleotide binding]; other site 523796003535 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 523796003536 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 523796003537 Walker A/P-loop; other site 523796003538 ATP binding site [chemical binding]; other site 523796003539 Q-loop/lid; other site 523796003540 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 523796003541 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 523796003542 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 523796003543 ABC transporter signature motif; other site 523796003544 Walker B; other site 523796003545 D-loop; other site 523796003546 H-loop/switch region; other site 523796003547 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 523796003548 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 523796003549 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 523796003550 P loop; other site 523796003551 GTP binding site [chemical binding]; other site 523796003552 putative DNA-binding protein; Validated; Region: PRK00118 523796003553 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 523796003554 signal recognition particle protein; Provisional; Region: PRK10867 523796003555 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 523796003556 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 523796003557 P loop; other site 523796003558 GTP binding site [chemical binding]; other site 523796003559 Signal peptide binding domain; Region: SRP_SPB; pfam02978 523796003560 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 523796003561 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 523796003562 RimM N-terminal domain; Region: RimM; pfam01782 523796003563 PRC-barrel domain; Region: PRC; pfam05239 523796003564 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 523796003565 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 523796003566 Predicted membrane protein [Function unknown]; Region: COG4485 523796003567 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 523796003568 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 523796003569 GTP/Mg2+ binding site [chemical binding]; other site 523796003570 G4 box; other site 523796003571 G5 box; other site 523796003572 G1 box; other site 523796003573 Switch I region; other site 523796003574 G2 box; other site 523796003575 G3 box; other site 523796003576 Switch II region; other site 523796003577 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 523796003578 RNA/DNA hybrid binding site [nucleotide binding]; other site 523796003579 active site 523796003580 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 523796003581 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 523796003582 CoA-ligase; Region: Ligase_CoA; pfam00549 523796003583 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 523796003584 CoA binding domain; Region: CoA_binding; pfam02629 523796003585 CoA-ligase; Region: Ligase_CoA; pfam00549 523796003586 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 523796003587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 523796003588 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 523796003589 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 523796003590 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 523796003591 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 523796003592 DNA topoisomerase I; Validated; Region: PRK05582 523796003593 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 523796003594 active site 523796003595 interdomain interaction site; other site 523796003596 putative metal-binding site [ion binding]; other site 523796003597 nucleotide binding site [chemical binding]; other site 523796003598 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 523796003599 domain I; other site 523796003600 DNA binding groove [nucleotide binding] 523796003601 phosphate binding site [ion binding]; other site 523796003602 domain II; other site 523796003603 domain III; other site 523796003604 nucleotide binding site [chemical binding]; other site 523796003605 catalytic site [active] 523796003606 domain IV; other site 523796003607 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 523796003608 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 523796003609 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 523796003610 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 523796003611 Glucose inhibited division protein A; Region: GIDA; pfam01134 523796003612 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 523796003613 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 523796003614 active site 523796003615 DNA binding site [nucleotide binding] 523796003616 Int/Topo IB signature motif; other site 523796003617 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 523796003618 active site 523796003619 HslU subunit interaction site [polypeptide binding]; other site 523796003620 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 523796003621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796003622 Walker A motif; other site 523796003623 ATP binding site [chemical binding]; other site 523796003624 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 523796003625 Walker B motif; other site 523796003626 arginine finger; other site 523796003627 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 523796003628 transcriptional repressor CodY; Validated; Region: PRK04158 523796003629 CodY GAF-like domain; Region: CodY; pfam06018 523796003630 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 523796003631 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 523796003632 rRNA interaction site [nucleotide binding]; other site 523796003633 S8 interaction site; other site 523796003634 putative laminin-1 binding site; other site 523796003635 elongation factor Ts; Provisional; Region: tsf; PRK09377 523796003636 UBA/TS-N domain; Region: UBA; pfam00627 523796003637 Elongation factor TS; Region: EF_TS; pfam00889 523796003638 Elongation factor TS; Region: EF_TS; pfam00889 523796003639 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 523796003640 putative nucleotide binding site [chemical binding]; other site 523796003641 uridine monophosphate binding site [chemical binding]; other site 523796003642 homohexameric interface [polypeptide binding]; other site 523796003643 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 523796003644 hinge region; other site 523796003645 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 523796003646 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 523796003647 catalytic residue [active] 523796003648 putative FPP diphosphate binding site; other site 523796003649 putative FPP binding hydrophobic cleft; other site 523796003650 dimer interface [polypeptide binding]; other site 523796003651 putative IPP diphosphate binding site; other site 523796003652 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 523796003653 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 523796003654 RIP metalloprotease RseP; Region: TIGR00054 523796003655 active site 523796003656 putative substrate binding region [chemical binding]; other site 523796003657 prolyl-tRNA synthetase; Provisional; Region: PRK09194 523796003658 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 523796003659 dimer interface [polypeptide binding]; other site 523796003660 motif 1; other site 523796003661 active site 523796003662 motif 2; other site 523796003663 motif 3; other site 523796003664 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 523796003665 anticodon binding site; other site 523796003666 DNA polymerase III PolC; Validated; Region: polC; PRK00448 523796003667 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 523796003668 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 523796003669 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 523796003670 generic binding surface II; other site 523796003671 generic binding surface I; other site 523796003672 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 523796003673 active site 523796003674 putative PHP Thumb interface [polypeptide binding]; other site 523796003675 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 523796003676 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 523796003677 Sm and related proteins; Region: Sm_like; cl00259 523796003678 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 523796003679 putative oligomer interface [polypeptide binding]; other site 523796003680 putative RNA binding site [nucleotide binding]; other site 523796003681 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 523796003682 NusA N-terminal domain; Region: NusA_N; pfam08529 523796003683 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 523796003684 RNA binding site [nucleotide binding]; other site 523796003685 homodimer interface [polypeptide binding]; other site 523796003686 NusA-like KH domain; Region: KH_5; pfam13184 523796003687 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 523796003688 G-X-X-G motif; other site 523796003689 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 523796003690 putative RNA binding cleft [nucleotide binding]; other site 523796003691 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 523796003692 translation initiation factor IF-2; Validated; Region: infB; PRK05306 523796003693 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 523796003694 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 523796003695 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 523796003696 G1 box; other site 523796003697 putative GEF interaction site [polypeptide binding]; other site 523796003698 GTP/Mg2+ binding site [chemical binding]; other site 523796003699 Switch I region; other site 523796003700 G2 box; other site 523796003701 G3 box; other site 523796003702 Switch II region; other site 523796003703 G4 box; other site 523796003704 G5 box; other site 523796003705 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 523796003706 Translation-initiation factor 2; Region: IF-2; pfam11987 523796003707 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 523796003708 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 523796003709 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 523796003710 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 523796003711 RNA binding site [nucleotide binding]; other site 523796003712 active site 523796003713 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 523796003714 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 523796003715 active site 523796003716 Riboflavin kinase; Region: Flavokinase; smart00904 523796003717 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 523796003718 16S/18S rRNA binding site [nucleotide binding]; other site 523796003719 S13e-L30e interaction site [polypeptide binding]; other site 523796003720 25S rRNA binding site [nucleotide binding]; other site 523796003721 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 523796003722 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 523796003723 RNase E interface [polypeptide binding]; other site 523796003724 trimer interface [polypeptide binding]; other site 523796003725 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 523796003726 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 523796003727 RNase E interface [polypeptide binding]; other site 523796003728 trimer interface [polypeptide binding]; other site 523796003729 active site 523796003730 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 523796003731 putative nucleic acid binding region [nucleotide binding]; other site 523796003732 G-X-X-G motif; other site 523796003733 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 523796003734 RNA binding site [nucleotide binding]; other site 523796003735 domain interface; other site 523796003736 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 523796003737 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523796003738 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 523796003739 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 523796003740 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523796003741 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 523796003742 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 523796003743 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 523796003744 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 523796003745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 523796003746 DNA-binding site [nucleotide binding]; DNA binding site 523796003747 UTRA domain; Region: UTRA; pfam07702 523796003748 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 523796003749 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 523796003750 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 523796003751 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 523796003752 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 523796003753 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 523796003754 classical (c) SDRs; Region: SDR_c; cd05233 523796003755 NAD(P) binding site [chemical binding]; other site 523796003756 active site 523796003757 ACT domain; Region: ACT; pfam01842 523796003758 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 523796003759 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 523796003760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796003761 non-specific DNA binding site [nucleotide binding]; other site 523796003762 salt bridge; other site 523796003763 sequence-specific DNA binding site [nucleotide binding]; other site 523796003764 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 523796003765 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 523796003766 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 523796003767 putative MPT binding site; other site 523796003768 recombinase A; Provisional; Region: recA; PRK09354 523796003769 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 523796003770 hexamer interface [polypeptide binding]; other site 523796003771 Walker A motif; other site 523796003772 ATP binding site [chemical binding]; other site 523796003773 Walker B motif; other site 523796003774 phosphodiesterase; Provisional; Region: PRK12704 523796003775 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523796003776 Zn2+ binding site [ion binding]; other site 523796003777 Mg2+ binding site [ion binding]; other site 523796003778 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 523796003779 putative active site [active] 523796003780 metal binding site [ion binding]; metal-binding site 523796003781 homodimer binding site [polypeptide binding]; other site 523796003782 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 523796003783 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 523796003784 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 523796003785 dimer interface [polypeptide binding]; other site 523796003786 PYR/PP interface [polypeptide binding]; other site 523796003787 TPP binding site [chemical binding]; other site 523796003788 substrate binding site [chemical binding]; other site 523796003789 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 523796003790 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 523796003791 TPP-binding site [chemical binding]; other site 523796003792 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 523796003793 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 523796003794 Helix-turn-helix domain; Region: HTH_38; pfam13936 523796003795 Integrase core domain; Region: rve; pfam00665 523796003796 Uncharacterized conserved protein [Function unknown]; Region: COG0011 523796003797 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 523796003798 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 523796003799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796003800 FeS/SAM binding site; other site 523796003801 TRAM domain; Region: TRAM; pfam01938 523796003802 Predicted membrane protein [Function unknown]; Region: COG4550 523796003803 Predicted membrane protein [Function unknown]; Region: COG4732 523796003804 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 523796003805 MutS domain I; Region: MutS_I; pfam01624 523796003806 MutS domain II; Region: MutS_II; pfam05188 523796003807 MutS domain III; Region: MutS_III; pfam05192 523796003808 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 523796003809 Walker A/P-loop; other site 523796003810 ATP binding site [chemical binding]; other site 523796003811 Q-loop/lid; other site 523796003812 ABC transporter signature motif; other site 523796003813 Walker B; other site 523796003814 D-loop; other site 523796003815 H-loop/switch region; other site 523796003816 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 523796003817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796003818 ATP binding site [chemical binding]; other site 523796003819 Mg2+ binding site [ion binding]; other site 523796003820 G-X-G motif; other site 523796003821 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 523796003822 ATP binding site [chemical binding]; other site 523796003823 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 523796003824 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 523796003825 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 523796003826 amphipathic channel; other site 523796003827 Asn-Pro-Ala signature motifs; other site 523796003828 glycerol kinase; Provisional; Region: glpK; PRK00047 523796003829 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 523796003830 N- and C-terminal domain interface [polypeptide binding]; other site 523796003831 active site 523796003832 MgATP binding site [chemical binding]; other site 523796003833 catalytic site [active] 523796003834 metal binding site [ion binding]; metal-binding site 523796003835 glycerol binding site [chemical binding]; other site 523796003836 homotetramer interface [polypeptide binding]; other site 523796003837 homodimer interface [polypeptide binding]; other site 523796003838 FBP binding site [chemical binding]; other site 523796003839 protein IIAGlc interface [polypeptide binding]; other site 523796003840 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 523796003841 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 523796003842 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 523796003843 PGAP1-like protein; Region: PGAP1; pfam07819 523796003844 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 523796003845 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 523796003846 bacterial Hfq-like; Region: Hfq; cd01716 523796003847 hexamer interface [polypeptide binding]; other site 523796003848 Sm1 motif; other site 523796003849 RNA binding site [nucleotide binding]; other site 523796003850 Sm2 motif; other site 523796003851 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 523796003852 catalytic residues [active] 523796003853 dimer interface [polypeptide binding]; other site 523796003854 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 523796003855 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 523796003856 HflX GTPase family; Region: HflX; cd01878 523796003857 G1 box; other site 523796003858 GTP/Mg2+ binding site [chemical binding]; other site 523796003859 Switch I region; other site 523796003860 G2 box; other site 523796003861 G3 box; other site 523796003862 Switch II region; other site 523796003863 G4 box; other site 523796003864 G5 box; other site 523796003865 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 523796003866 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 523796003867 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 523796003868 DNA binding residues [nucleotide binding] 523796003869 putative dimer interface [polypeptide binding]; other site 523796003870 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 523796003871 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 523796003872 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 523796003873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 523796003874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 523796003875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 523796003876 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 523796003877 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 523796003878 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 523796003879 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523796003880 catalytic residue [active] 523796003881 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 523796003882 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 523796003883 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 523796003884 putative active site [active] 523796003885 catalytic site [active] 523796003886 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 523796003887 putative active site [active] 523796003888 catalytic site [active] 523796003889 Staphylococcal nuclease homologues; Region: SNc; smart00318 523796003890 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 523796003891 Catalytic site; other site 523796003892 aspartate kinase; Reviewed; Region: PRK09034 523796003893 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 523796003894 putative catalytic residues [active] 523796003895 putative nucleotide binding site [chemical binding]; other site 523796003896 putative aspartate binding site [chemical binding]; other site 523796003897 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 523796003898 allosteric regulatory residue; other site 523796003899 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 523796003900 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 523796003901 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 523796003902 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 523796003903 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 523796003904 homodimer interface [polypeptide binding]; other site 523796003905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796003906 catalytic residue [active] 523796003907 homoserine kinase; Provisional; Region: PRK01212 523796003908 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 523796003909 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 523796003910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796003911 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 523796003912 active site 523796003913 motif I; other site 523796003914 motif II; other site 523796003915 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 523796003916 lysine transporter; Provisional; Region: PRK10836 523796003917 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 523796003918 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 523796003919 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 523796003920 tetramer interface [polypeptide binding]; other site 523796003921 heme binding pocket [chemical binding]; other site 523796003922 NADPH binding site [chemical binding]; other site 523796003923 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 523796003924 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 523796003925 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 523796003926 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 523796003927 active site 523796003928 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 523796003929 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 523796003930 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 523796003931 LexA repressor; Validated; Region: PRK00215 523796003932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523796003933 putative DNA binding site [nucleotide binding]; other site 523796003934 putative Zn2+ binding site [ion binding]; other site 523796003935 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 523796003936 Catalytic site [active] 523796003937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 523796003938 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 523796003939 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 523796003940 TPP-binding site [chemical binding]; other site 523796003941 dimer interface [polypeptide binding]; other site 523796003942 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 523796003943 PYR/PP interface [polypeptide binding]; other site 523796003944 dimer interface [polypeptide binding]; other site 523796003945 TPP binding site [chemical binding]; other site 523796003946 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523796003947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 523796003948 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 523796003949 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 523796003950 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 523796003951 active site 523796003952 metal binding site [ion binding]; metal-binding site 523796003953 DNA binding site [nucleotide binding] 523796003954 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 523796003955 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 523796003956 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 523796003957 Walker A/P-loop; other site 523796003958 ATP binding site [chemical binding]; other site 523796003959 Q-loop/lid; other site 523796003960 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 523796003961 Q-loop/lid; other site 523796003962 ABC transporter signature motif; other site 523796003963 Walker B; other site 523796003964 D-loop; other site 523796003965 H-loop/switch region; other site 523796003966 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 523796003967 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 523796003968 aconitate hydratase; Validated; Region: PRK09277 523796003969 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 523796003970 substrate binding site [chemical binding]; other site 523796003971 ligand binding site [chemical binding]; other site 523796003972 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 523796003973 substrate binding site [chemical binding]; other site 523796003974 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 523796003975 active site 523796003976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 523796003977 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 523796003978 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 523796003979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796003980 ATP binding site [chemical binding]; other site 523796003981 Mg2+ binding site [ion binding]; other site 523796003982 G-X-G motif; other site 523796003983 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 523796003984 anchoring element; other site 523796003985 dimer interface [polypeptide binding]; other site 523796003986 ATP binding site [chemical binding]; other site 523796003987 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 523796003988 active site 523796003989 metal binding site [ion binding]; metal-binding site 523796003990 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 523796003991 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 523796003992 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 523796003993 CAP-like domain; other site 523796003994 active site 523796003995 primary dimer interface [polypeptide binding]; other site 523796003996 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523796003997 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 523796003998 amino acid carrier protein; Region: agcS; TIGR00835 523796003999 CAT RNA binding domain; Region: CAT_RBD; cl03904 523796004000 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 523796004001 PRD domain; Region: PRD; pfam00874 523796004002 PRD domain; Region: PRD; pfam00874 523796004003 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 523796004004 Predicted integral membrane protein [Function unknown]; Region: COG0392 523796004005 Uncharacterized conserved protein [Function unknown]; Region: COG2898 523796004006 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 523796004007 methionine sulfoxide reductase A; Provisional; Region: PRK14054 523796004008 Transcriptional regulator [Transcription]; Region: LytR; COG1316 523796004009 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 523796004010 active site 1 [active] 523796004011 dimer interface [polypeptide binding]; other site 523796004012 hexamer interface [polypeptide binding]; other site 523796004013 active site 2 [active] 523796004014 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 523796004015 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 523796004016 active site 523796004017 DNA binding site [nucleotide binding] 523796004018 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 523796004019 prephenate dehydrogenase; Validated; Region: PRK08507 523796004020 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 523796004021 putative oligomer interface [polypeptide binding]; other site 523796004022 putative active site [active] 523796004023 metal binding site [ion binding]; metal-binding site 523796004024 anthranilate synthase component I; Provisional; Region: PRK13567 523796004025 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 523796004026 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 523796004027 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 523796004028 Glutamine amidotransferase class-I; Region: GATase; pfam00117 523796004029 glutamine binding [chemical binding]; other site 523796004030 catalytic triad [active] 523796004031 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 523796004032 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 523796004033 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 523796004034 active site 523796004035 ribulose/triose binding site [chemical binding]; other site 523796004036 phosphate binding site [ion binding]; other site 523796004037 substrate (anthranilate) binding pocket [chemical binding]; other site 523796004038 product (indole) binding pocket [chemical binding]; other site 523796004039 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 523796004040 active site 523796004041 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 523796004042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796004043 catalytic residue [active] 523796004044 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 523796004045 substrate binding site [chemical binding]; other site 523796004046 active site 523796004047 catalytic residues [active] 523796004048 heterodimer interface [polypeptide binding]; other site 523796004049 FemAB family; Region: FemAB; pfam02388 523796004050 FemAB family; Region: FemAB; pfam02388 523796004051 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 523796004052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796004053 active site 523796004054 motif I; other site 523796004055 motif II; other site 523796004056 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 523796004057 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523796004058 Walker A/P-loop; other site 523796004059 ATP binding site [chemical binding]; other site 523796004060 Q-loop/lid; other site 523796004061 ABC transporter signature motif; other site 523796004062 Walker B; other site 523796004063 D-loop; other site 523796004064 H-loop/switch region; other site 523796004065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796004066 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 523796004067 Walker A/P-loop; other site 523796004068 ATP binding site [chemical binding]; other site 523796004069 Q-loop/lid; other site 523796004070 ABC transporter signature motif; other site 523796004071 Walker B; other site 523796004072 D-loop; other site 523796004073 H-loop/switch region; other site 523796004074 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 523796004075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796004076 dimer interface [polypeptide binding]; other site 523796004077 conserved gate region; other site 523796004078 putative PBP binding loops; other site 523796004079 ABC-ATPase subunit interface; other site 523796004080 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523796004081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796004082 dimer interface [polypeptide binding]; other site 523796004083 conserved gate region; other site 523796004084 putative PBP binding loops; other site 523796004085 ABC-ATPase subunit interface; other site 523796004086 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 523796004087 oligoendopeptidase F; Region: pepF; TIGR00181 523796004088 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 523796004089 active site 523796004090 Zn binding site [ion binding]; other site 523796004091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 523796004092 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 523796004093 PhoU domain; Region: PhoU; pfam01895 523796004094 PhoU domain; Region: PhoU; pfam01895 523796004095 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 523796004096 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 523796004097 Walker A/P-loop; other site 523796004098 ATP binding site [chemical binding]; other site 523796004099 Q-loop/lid; other site 523796004100 ABC transporter signature motif; other site 523796004101 Walker B; other site 523796004102 D-loop; other site 523796004103 H-loop/switch region; other site 523796004104 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 523796004105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796004106 dimer interface [polypeptide binding]; other site 523796004107 conserved gate region; other site 523796004108 putative PBP binding loops; other site 523796004109 ABC-ATPase subunit interface; other site 523796004110 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 523796004111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796004112 dimer interface [polypeptide binding]; other site 523796004113 conserved gate region; other site 523796004114 putative PBP binding loops; other site 523796004115 ABC-ATPase subunit interface; other site 523796004116 phosphate binding protein; Region: ptsS_2; TIGR02136 523796004117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 523796004118 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 523796004119 S1 domain; Region: S1_2; pfam13509 523796004120 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 523796004121 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523796004122 ABC transporter; Region: ABC_tran_2; pfam12848 523796004123 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523796004124 aspartate kinase; Reviewed; Region: PRK06635 523796004125 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 523796004126 putative nucleotide binding site [chemical binding]; other site 523796004127 putative catalytic residues [active] 523796004128 putative Mg ion binding site [ion binding]; other site 523796004129 putative aspartate binding site [chemical binding]; other site 523796004130 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 523796004131 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 523796004132 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 523796004133 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 523796004134 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 523796004135 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 523796004136 dimer interface [polypeptide binding]; other site 523796004137 active site 523796004138 catalytic residue [active] 523796004139 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 523796004140 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 523796004141 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 523796004142 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 523796004143 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 523796004144 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 523796004145 active site 523796004146 trimer interface [polypeptide binding]; other site 523796004147 substrate binding site [chemical binding]; other site 523796004148 CoA binding site [chemical binding]; other site 523796004149 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 523796004150 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 523796004151 metal binding site [ion binding]; metal-binding site 523796004152 dimer interface [polypeptide binding]; other site 523796004153 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 523796004154 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 523796004155 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523796004156 catalytic residue [active] 523796004157 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 523796004158 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 523796004159 active site 523796004160 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523796004161 substrate binding site [chemical binding]; other site 523796004162 catalytic residues [active] 523796004163 dimer interface [polypeptide binding]; other site 523796004164 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 523796004165 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 523796004166 DNA-binding site [nucleotide binding]; DNA binding site 523796004167 RNA-binding motif; other site 523796004168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 523796004169 acylphosphatase; Provisional; Region: PRK14431 523796004170 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 523796004171 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 523796004172 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 523796004173 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 523796004174 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 523796004175 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 523796004176 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 523796004177 metal ion-dependent adhesion site (MIDAS); other site 523796004178 MoxR-like ATPases [General function prediction only]; Region: COG0714 523796004179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796004180 Walker A motif; other site 523796004181 ATP binding site [chemical binding]; other site 523796004182 Walker B motif; other site 523796004183 arginine finger; other site 523796004184 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 523796004185 active site 523796004186 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 523796004187 active site 523796004188 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 523796004189 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523796004190 E3 interaction surface; other site 523796004191 lipoyl attachment site [posttranslational modification]; other site 523796004192 e3 binding domain; Region: E3_binding; pfam02817 523796004193 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 523796004194 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 523796004195 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 523796004196 TPP-binding site [chemical binding]; other site 523796004197 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 523796004198 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 523796004199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523796004200 HAMP domain; Region: HAMP; pfam00672 523796004201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523796004202 dimer interface [polypeptide binding]; other site 523796004203 phosphorylation site [posttranslational modification] 523796004204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796004205 ATP binding site [chemical binding]; other site 523796004206 Mg2+ binding site [ion binding]; other site 523796004207 G-X-G motif; other site 523796004208 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523796004209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796004210 active site 523796004211 phosphorylation site [posttranslational modification] 523796004212 intermolecular recognition site; other site 523796004213 dimerization interface [polypeptide binding]; other site 523796004214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523796004215 DNA binding site [nucleotide binding] 523796004216 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 523796004217 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 523796004218 active site 523796004219 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 523796004220 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 523796004221 active site 523796004222 homodimer interface [polypeptide binding]; other site 523796004223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 523796004224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796004225 Coenzyme A binding pocket [chemical binding]; other site 523796004226 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 523796004227 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 523796004228 Catalytic dyad [active] 523796004229 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 523796004230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 523796004231 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 523796004232 HPr interaction site; other site 523796004233 glycerol kinase (GK) interaction site [polypeptide binding]; other site 523796004234 active site 523796004235 phosphorylation site [posttranslational modification] 523796004236 methionine sulfoxide reductase B; Provisional; Region: PRK00222 523796004237 methionine sulfoxide reductase A; Provisional; Region: PRK13014 523796004238 EDD domain protein, DegV family; Region: DegV; TIGR00762 523796004239 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 523796004240 folate binding site [chemical binding]; other site 523796004241 NADP+ binding site [chemical binding]; other site 523796004242 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 523796004243 dimerization interface [polypeptide binding]; other site 523796004244 active site 523796004245 Disulphide isomerase; Region: Disulph_isomer; pfam06491 523796004246 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 523796004247 Virulence factor; Region: Virulence_fact; pfam13769 523796004248 HEAT repeats; Region: HEAT_2; pfam13646 523796004249 HEAT repeat; Region: HEAT; pfam02985 523796004250 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 523796004251 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 523796004252 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 523796004253 RNA/DNA hybrid binding site [nucleotide binding]; other site 523796004254 active site 523796004255 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 523796004256 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 523796004257 Predicted membrane protein [Function unknown]; Region: COG1511 523796004258 GA module; Region: GA; smart00844 523796004259 GA module; Region: GA; smart00844 523796004260 GA module; Region: GA; smart00844 523796004261 GA module; Region: GA; smart00844 523796004262 GA module; Region: GA; smart00844 523796004263 GA module; Region: GA; smart00844 523796004264 GA module; Region: GA; smart00844 523796004265 GA module; Region: GA; smart00844 523796004266 GA module; Region: GA; smart00844 523796004267 GA module; Region: GA; smart00844 523796004268 GA module; Region: GA; smart00844 523796004269 GA module; Region: GA; smart00844 523796004270 GA module; Region: GA; smart00844 523796004271 GA module; Region: GA; smart00844 523796004272 GA module; Region: GA; smart00844 523796004273 Predicted membrane protein [Function unknown]; Region: COG1511 523796004274 GA module; Region: GA; smart00844 523796004275 GA module; Region: GA; smart00844 523796004276 AAA domain; Region: AAA_27; pfam13514 523796004277 GA module; Region: GA; smart00844 523796004278 GA module; Region: GA; smart00844 523796004279 GA module; Region: GA; smart00844 523796004280 GA module; Region: GA; smart00844 523796004281 GA module; Region: GA; smart00844 523796004282 Predicted membrane protein [Function unknown]; Region: COG1511 523796004283 GA module; Region: GA; smart00844 523796004284 GA module; Region: GA; smart00844 523796004285 GA module; Region: GA; smart00844 523796004286 GA module; Region: GA; smart00844 523796004287 Predicted membrane protein [Function unknown]; Region: COG1511 523796004288 GA module; Region: GA; smart00844 523796004289 GA module; Region: GA; smart00844 523796004290 GA module; Region: GA; smart00844 523796004291 GA module; Region: GA; smart00844 523796004292 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 523796004293 GA module; Region: GA; smart00844 523796004294 GA module; Region: GA; smart00844 523796004295 GA module; Region: GA; smart00844 523796004296 GA module; Region: GA; smart00844 523796004297 GA module; Region: GA; smart00844 523796004298 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 523796004299 GA module; Region: GA; smart00844 523796004300 GA module; Region: GA; smart00844 523796004301 GA module; Region: GA; smart00844 523796004302 GA module; Region: GA; smart00844 523796004303 GA module; Region: GA; smart00844 523796004304 GA module; Region: GA; smart00844 523796004305 GA module; Region: GA; smart00844 523796004306 GA module; Region: GA; smart00844 523796004307 GA module; Region: GA; smart00844 523796004308 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 523796004309 GA module; Region: GA; smart00844 523796004310 GA module; Region: GA; smart00844 523796004311 GA module; Region: GA; smart00844 523796004312 GA module; Region: GA; pfam01468 523796004313 GA module; Region: GA; smart00844 523796004314 GA module; Region: GA; smart00844 523796004315 GA module; Region: GA; smart00844 523796004316 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 523796004317 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796004318 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796004319 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796004320 RecF/RecN/SMC N terminal domain; Region: SMC_N; pfam02463 523796004321 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796004322 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796004323 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796004324 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796004325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796004326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796004327 putative substrate translocation pore; other site 523796004328 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 523796004329 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 523796004330 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 523796004331 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 523796004332 tetramer interface [polypeptide binding]; other site 523796004333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796004334 catalytic residue [active] 523796004335 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 523796004336 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 523796004337 hexamer interface [polypeptide binding]; other site 523796004338 ligand binding site [chemical binding]; other site 523796004339 putative active site [active] 523796004340 NAD(P) binding site [chemical binding]; other site 523796004341 5'-3' exonuclease; Region: 53EXOc; smart00475 523796004342 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 523796004343 active site 523796004344 metal binding site 1 [ion binding]; metal-binding site 523796004345 putative 5' ssDNA interaction site; other site 523796004346 metal binding site 3; metal-binding site 523796004347 metal binding site 2 [ion binding]; metal-binding site 523796004348 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 523796004349 putative DNA binding site [nucleotide binding]; other site 523796004350 putative metal binding site [ion binding]; other site 523796004351 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 523796004352 G1 box; other site 523796004353 GTP/Mg2+ binding site [chemical binding]; other site 523796004354 G2 box; other site 523796004355 Switch I region; other site 523796004356 G3 box; other site 523796004357 Switch II region; other site 523796004358 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 523796004359 G4 box; other site 523796004360 Dynamin family; Region: Dynamin_N; pfam00350 523796004361 G1 box; other site 523796004362 GTP/Mg2+ binding site [chemical binding]; other site 523796004363 G2 box; other site 523796004364 Switch I region; other site 523796004365 G3 box; other site 523796004366 Switch II region; other site 523796004367 G4 box; other site 523796004368 G5 box; other site 523796004369 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 523796004370 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 523796004371 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 523796004372 Cobalt transport protein component CbiN; Region: CbiN; cl00842 523796004373 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 523796004374 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 523796004375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 523796004376 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 523796004377 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 523796004378 hypothetical protein; Provisional; Region: PRK13660 523796004379 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 523796004380 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 523796004381 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 523796004382 Transglycosylase; Region: Transgly; pfam00912 523796004383 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 523796004384 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 523796004385 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 523796004386 minor groove reading motif; other site 523796004387 helix-hairpin-helix signature motif; other site 523796004388 substrate binding pocket [chemical binding]; other site 523796004389 active site 523796004390 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 523796004391 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 523796004392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 523796004393 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 523796004394 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 523796004395 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 523796004396 putative dimer interface [polypeptide binding]; other site 523796004397 putative anticodon binding site; other site 523796004398 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 523796004399 homodimer interface [polypeptide binding]; other site 523796004400 motif 1; other site 523796004401 motif 2; other site 523796004402 active site 523796004403 motif 3; other site 523796004404 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 523796004405 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 523796004406 active site 523796004407 catalytic site [active] 523796004408 substrate binding site [chemical binding]; other site 523796004409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 523796004410 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 523796004411 Biotin operon repressor [Transcription]; Region: BirA; COG1654 523796004412 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 523796004413 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 523796004414 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 523796004415 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 523796004416 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 523796004417 active site 523796004418 NTP binding site [chemical binding]; other site 523796004419 metal binding triad [ion binding]; metal-binding site 523796004420 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 523796004421 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 523796004422 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 523796004423 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 523796004424 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 523796004425 homodimer interface [polypeptide binding]; other site 523796004426 metal binding site [ion binding]; metal-binding site 523796004427 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 523796004428 Predicted membrane protein [Function unknown]; Region: COG4347 523796004429 Uncharacterized conserved protein [Function unknown]; Region: COG5582 523796004430 UPF0302 domain; Region: UPF0302; pfam08864 523796004431 IDEAL domain; Region: IDEAL; pfam08858 523796004432 TPR repeat; Region: TPR_11; pfam13414 523796004433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523796004434 binding surface 523796004435 TPR motif; other site 523796004436 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523796004437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523796004438 TPR motif; other site 523796004439 binding surface 523796004440 Tetratricopeptide repeat; Region: TPR_19; pfam14559 523796004441 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 523796004442 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 523796004443 hinge; other site 523796004444 active site 523796004445 Dehydroquinate synthase-like which includes dehydroquinate synthase, 2-deoxy-scyllo-inosose synthase, and 2-epi-5-epi-valiolone synthase; Region: DHQ-like; cd08169 523796004446 active site 523796004447 dimer interface [polypeptide binding]; other site 523796004448 metal binding site [ion binding]; metal-binding site 523796004449 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 523796004450 Tetramer interface [polypeptide binding]; other site 523796004451 active site 523796004452 FMN-binding site [chemical binding]; other site 523796004453 Nucleoside diphosphate kinase; Region: NDK; pfam00334 523796004454 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 523796004455 active site 523796004456 multimer interface [polypeptide binding]; other site 523796004457 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 523796004458 substrate binding pocket [chemical binding]; other site 523796004459 chain length determination region; other site 523796004460 substrate-Mg2+ binding site; other site 523796004461 catalytic residues [active] 523796004462 aspartate-rich region 1; other site 523796004463 active site lid residues [active] 523796004464 aspartate-rich region 2; other site 523796004465 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 523796004466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796004467 S-adenosylmethionine binding site [chemical binding]; other site 523796004468 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 523796004469 histone-like DNA-binding protein HU; Region: HU; cd13831 523796004470 dimer interface [polypeptide binding]; other site 523796004471 DNA binding site [nucleotide binding] 523796004472 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 523796004473 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 523796004474 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 523796004475 GTP-binding protein Der; Reviewed; Region: PRK00093 523796004476 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 523796004477 G1 box; other site 523796004478 GTP/Mg2+ binding site [chemical binding]; other site 523796004479 Switch I region; other site 523796004480 G2 box; other site 523796004481 Switch II region; other site 523796004482 G3 box; other site 523796004483 G4 box; other site 523796004484 G5 box; other site 523796004485 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 523796004486 G1 box; other site 523796004487 GTP/Mg2+ binding site [chemical binding]; other site 523796004488 Switch I region; other site 523796004489 G2 box; other site 523796004490 G3 box; other site 523796004491 Switch II region; other site 523796004492 G4 box; other site 523796004493 G5 box; other site 523796004494 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 523796004495 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 523796004496 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 523796004497 RNA binding site [nucleotide binding]; other site 523796004498 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 523796004499 RNA binding site [nucleotide binding]; other site 523796004500 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 523796004501 RNA binding site [nucleotide binding]; other site 523796004502 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 523796004503 RNA binding site [nucleotide binding]; other site 523796004504 cytidylate kinase; Provisional; Region: cmk; PRK00023 523796004505 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 523796004506 CMP-binding site; other site 523796004507 The sites determining sugar specificity; other site 523796004508 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 523796004509 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 523796004510 active site 523796004511 homotetramer interface [polypeptide binding]; other site 523796004512 homodimer interface [polypeptide binding]; other site 523796004513 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 523796004514 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 523796004515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796004516 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523796004517 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 523796004518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796004519 ATP binding site [chemical binding]; other site 523796004520 putative Mg++ binding site [ion binding]; other site 523796004521 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796004522 nucleotide binding region [chemical binding]; other site 523796004523 ATP-binding site [chemical binding]; other site 523796004524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 523796004525 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 523796004526 Predicted membrane protein [Function unknown]; Region: COG3601 523796004527 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 523796004528 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 523796004529 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 523796004530 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 523796004531 CHAP domain; Region: CHAP; pfam05257 523796004532 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 523796004533 amidase catalytic site [active] 523796004534 Zn binding residues [ion binding]; other site 523796004535 substrate binding site [chemical binding]; other site 523796004536 Bacterial SH3 domain; Region: SH3_5; pfam08460 523796004537 Bacteriophage holin; Region: Phage_holin_1; pfam04531 523796004538 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 523796004539 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 523796004540 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 523796004541 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 523796004542 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 523796004543 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 523796004544 hypothetical protein; Provisional; Region: PRK05926 523796004545 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 523796004546 Phage tail protein; Region: Sipho_tail; pfam05709 523796004547 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 523796004548 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 523796004549 Stathmin family; Region: Stathmin; pfam00836 523796004550 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 523796004551 Peptidase family M23; Region: Peptidase_M23; pfam01551 523796004552 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523796004553 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523796004554 catalytic residue [active] 523796004555 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 523796004556 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 523796004557 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 523796004558 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 523796004559 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 523796004560 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 523796004561 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 523796004562 oligomerization interface [polypeptide binding]; other site 523796004563 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 523796004564 Phage capsid family; Region: Phage_capsid; pfam05065 523796004565 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 523796004566 oligomer interface [polypeptide binding]; other site 523796004567 active site residues [active] 523796004568 Phage-related protein [Function unknown]; Region: COG4695; cl01923 523796004569 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 523796004570 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 523796004571 Phage Terminase; Region: Terminase_1; cl19862 523796004572 Phage terminase, small subunit; Region: Terminase_4; pfam05119 523796004573 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 523796004574 active site 523796004575 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 523796004576 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 523796004577 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796004578 ATP binding site [chemical binding]; other site 523796004579 putative Mg++ binding site [ion binding]; other site 523796004580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796004581 nucleotide binding region [chemical binding]; other site 523796004582 ATP-binding site [chemical binding]; other site 523796004583 VRR-NUC domain; Region: VRR_NUC; pfam08774 523796004584 Virulence-associated protein E; Region: VirE; pfam05272 523796004585 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 523796004586 Transcriptional activator RinB; Region: RinB; pfam06116 523796004587 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 523796004588 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 523796004589 dUTPase; Region: dUTPase_2; pfam08761 523796004590 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 523796004591 active site 523796004592 homodimer interface [polypeptide binding]; other site 523796004593 metal binding site [ion binding]; metal-binding site 523796004594 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 523796004595 YopX protein; Region: YopX; pfam09643 523796004596 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 523796004597 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 523796004598 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 523796004599 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 523796004600 active site 523796004601 DNA binding site [nucleotide binding] 523796004602 catalytic site [active] 523796004603 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 523796004604 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 523796004605 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 523796004606 Homeodomain-like domain; Region: HTH_23; pfam13384 523796004607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796004608 non-specific DNA binding site [nucleotide binding]; other site 523796004609 salt bridge; other site 523796004610 sequence-specific DNA binding site [nucleotide binding]; other site 523796004611 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523796004612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796004613 non-specific DNA binding site [nucleotide binding]; other site 523796004614 salt bridge; other site 523796004615 sequence-specific DNA binding site [nucleotide binding]; other site 523796004616 Predicted transcriptional regulator [Transcription]; Region: COG2932 523796004617 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 523796004618 Catalytic site [active] 523796004619 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 523796004620 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 523796004621 Int/Topo IB signature motif; other site 523796004622 Adhesin lipoprotein; Region: Lipoprotein_7; pfam01540 523796004623 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 523796004624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 523796004625 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523796004626 dimerization interface [polypeptide binding]; other site 523796004627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523796004628 dimer interface [polypeptide binding]; other site 523796004629 phosphorylation site [posttranslational modification] 523796004630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796004631 ATP binding site [chemical binding]; other site 523796004632 Mg2+ binding site [ion binding]; other site 523796004633 G-X-G motif; other site 523796004634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523796004635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796004636 active site 523796004637 phosphorylation site [posttranslational modification] 523796004638 intermolecular recognition site; other site 523796004639 dimerization interface [polypeptide binding]; other site 523796004640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523796004641 DNA binding site [nucleotide binding] 523796004642 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 523796004643 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523796004644 RNA binding surface [nucleotide binding]; other site 523796004645 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 523796004646 active site 523796004647 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 523796004648 ScpA/B protein; Region: ScpA_ScpB; cl00598 523796004649 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 523796004650 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 523796004651 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 523796004652 active site 523796004653 Int/Topo IB signature motif; other site 523796004654 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 523796004655 metal binding site 2 [ion binding]; metal-binding site 523796004656 putative DNA binding helix; other site 523796004657 metal binding site 1 [ion binding]; metal-binding site 523796004658 dimer interface [polypeptide binding]; other site 523796004659 structural Zn2+ binding site [ion binding]; other site 523796004660 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 523796004661 dimer interface [polypeptide binding]; other site 523796004662 ADP-ribose binding site [chemical binding]; other site 523796004663 active site 523796004664 nudix motif; other site 523796004665 metal binding site [ion binding]; metal-binding site 523796004666 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 523796004667 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 523796004668 active site 523796004669 catalytic tetrad [active] 523796004670 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 523796004671 classical (c) SDRs; Region: SDR_c; cd05233 523796004672 NAD(P) binding site [chemical binding]; other site 523796004673 active site 523796004674 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 523796004675 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 523796004676 ribonuclease Z; Region: RNase_Z; TIGR02651 523796004677 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 523796004678 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 523796004679 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 523796004680 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523796004681 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 523796004682 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 523796004683 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 523796004684 Ca binding site [ion binding]; other site 523796004685 active site 523796004686 catalytic site [active] 523796004687 Transcriptional regulators [Transcription]; Region: PurR; COG1609 523796004688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 523796004689 DNA binding site [nucleotide binding] 523796004690 domain linker motif; other site 523796004691 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 523796004692 putative ligand binding site [chemical binding]; other site 523796004693 putative dimerization interface [polypeptide binding]; other site 523796004694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523796004695 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 523796004696 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 523796004697 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 523796004698 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 523796004699 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 523796004700 peptidase T-like protein; Region: PepT-like; TIGR01883 523796004701 metal binding site [ion binding]; metal-binding site 523796004702 putative dimer interface [polypeptide binding]; other site 523796004703 Predicted membrane protein [Function unknown]; Region: COG4129 523796004704 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 523796004705 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 523796004706 Disulphide isomerase; Region: Disulph_isomer; pfam06491 523796004707 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523796004708 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 523796004709 E3 interaction surface; other site 523796004710 lipoyl attachment site [posttranslational modification]; other site 523796004711 e3 binding domain; Region: E3_binding; pfam02817 523796004712 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 523796004713 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 523796004714 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 523796004715 alpha subunit interface [polypeptide binding]; other site 523796004716 TPP binding site [chemical binding]; other site 523796004717 heterodimer interface [polypeptide binding]; other site 523796004718 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523796004719 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 523796004720 tetramer interface [polypeptide binding]; other site 523796004721 TPP-binding site [chemical binding]; other site 523796004722 heterodimer interface [polypeptide binding]; other site 523796004723 phosphorylation loop region [posttranslational modification] 523796004724 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 523796004725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796004726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796004727 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 523796004728 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 523796004729 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 523796004730 Walker A/P-loop; other site 523796004731 ATP binding site [chemical binding]; other site 523796004732 Q-loop/lid; other site 523796004733 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 523796004734 ABC transporter signature motif; other site 523796004735 Walker B; other site 523796004736 D-loop; other site 523796004737 H-loop/switch region; other site 523796004738 arginine repressor; Provisional; Region: PRK04280 523796004739 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 523796004740 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 523796004741 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 523796004742 substrate binding pocket [chemical binding]; other site 523796004743 chain length determination region; other site 523796004744 substrate-Mg2+ binding site; other site 523796004745 catalytic residues [active] 523796004746 aspartate-rich region 1; other site 523796004747 active site lid residues [active] 523796004748 aspartate-rich region 2; other site 523796004749 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 523796004750 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 523796004751 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 523796004752 generic binding surface II; other site 523796004753 generic binding surface I; other site 523796004754 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 523796004755 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 523796004756 putative RNA binding site [nucleotide binding]; other site 523796004757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 523796004758 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 523796004759 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523796004760 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 523796004761 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 523796004762 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 523796004763 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 523796004764 carboxyltransferase (CT) interaction site; other site 523796004765 biotinylation site [posttranslational modification]; other site 523796004766 elongation factor P; Validated; Region: PRK00529 523796004767 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 523796004768 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 523796004769 RNA binding site [nucleotide binding]; other site 523796004770 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 523796004771 RNA binding site [nucleotide binding]; other site 523796004772 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 523796004773 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 523796004774 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 523796004775 active site 523796004776 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 523796004777 Nucleopolyhedrovirus protein of unknown function (DUF912); Region: DUF912; pfam06024 523796004778 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 523796004779 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523796004780 active site residue [active] 523796004781 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 523796004782 tetramer interface [polypeptide binding]; other site 523796004783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796004784 catalytic residue [active] 523796004785 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 523796004786 tetramer interface [polypeptide binding]; other site 523796004787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796004788 catalytic residue [active] 523796004789 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 523796004790 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 523796004791 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 523796004792 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 523796004793 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 523796004794 ADP binding site [chemical binding]; other site 523796004795 magnesium binding site [ion binding]; other site 523796004796 putative shikimate binding site; other site 523796004797 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 523796004798 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 523796004799 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 523796004800 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 523796004801 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 523796004802 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 523796004803 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 523796004804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 523796004805 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 523796004806 Walker A motif; other site 523796004807 ATP binding site [chemical binding]; other site 523796004808 Walker B motif; other site 523796004809 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523796004810 Uncharacterized conserved protein [Function unknown]; Region: COG0011 523796004811 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 523796004812 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 523796004813 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 523796004814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796004815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523796004816 binding surface 523796004817 TPR motif; other site 523796004818 TPR repeat; Region: TPR_11; pfam13414 523796004819 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 523796004820 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 523796004821 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 523796004822 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 523796004823 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 523796004824 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 523796004825 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 523796004826 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 523796004827 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 523796004828 metal binding site 2 [ion binding]; metal-binding site 523796004829 putative DNA binding helix; other site 523796004830 metal binding site 1 [ion binding]; metal-binding site 523796004831 dimer interface [polypeptide binding]; other site 523796004832 structural Zn2+ binding site [ion binding]; other site 523796004833 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 523796004834 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796004835 ABC-ATPase subunit interface; other site 523796004836 dimer interface [polypeptide binding]; other site 523796004837 putative PBP binding regions; other site 523796004838 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 523796004839 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 523796004840 endonuclease IV; Provisional; Region: PRK01060 523796004841 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 523796004842 AP (apurinic/apyrimidinic) site pocket; other site 523796004843 DNA interaction; other site 523796004844 Metal-binding active site; metal-binding site 523796004845 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 523796004846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 523796004847 ATP binding site [chemical binding]; other site 523796004848 putative Mg++ binding site [ion binding]; other site 523796004849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796004850 nucleotide binding region [chemical binding]; other site 523796004851 ATP-binding site [chemical binding]; other site 523796004852 Uncharacterized conserved protein [Function unknown]; Region: COG0327 523796004853 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 523796004854 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 523796004855 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 523796004856 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 523796004857 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523796004858 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 523796004859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523796004860 DNA binding residues [nucleotide binding] 523796004861 DNA primase, catalytic core; Region: dnaG; TIGR01391 523796004862 CHC2 zinc finger; Region: zf-CHC2; pfam01807 523796004863 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 523796004864 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 523796004865 active site 523796004866 metal binding site [ion binding]; metal-binding site 523796004867 interdomain interaction site; other site 523796004868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 523796004869 FOG: CBS domain [General function prediction only]; Region: COG0517 523796004870 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 523796004871 glycyl-tRNA synthetase; Provisional; Region: PRK04173 523796004872 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 523796004873 motif 1; other site 523796004874 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 523796004875 active site 523796004876 motif 2; other site 523796004877 motif 3; other site 523796004878 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 523796004879 anticodon binding site; other site 523796004880 DNA repair protein RecO; Region: reco; TIGR00613 523796004881 Recombination protein O N terminal; Region: RecO_N; pfam11967 523796004882 Recombination protein O C terminal; Region: RecO_C; pfam02565 523796004883 GTPase Era; Reviewed; Region: era; PRK00089 523796004884 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 523796004885 G1 box; other site 523796004886 GTP/Mg2+ binding site [chemical binding]; other site 523796004887 Switch I region; other site 523796004888 G2 box; other site 523796004889 Switch II region; other site 523796004890 G3 box; other site 523796004891 G4 box; other site 523796004892 G5 box; other site 523796004893 KH domain; Region: KH_2; pfam07650 523796004894 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 523796004895 active site 523796004896 catalytic motif [active] 523796004897 Zn binding site [ion binding]; other site 523796004898 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 523796004899 trimer interface [polypeptide binding]; other site 523796004900 putative active site [active] 523796004901 Zn binding site [ion binding]; other site 523796004902 metal-binding heat shock protein; Provisional; Region: PRK00016 523796004903 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 523796004904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796004905 ATP binding site [chemical binding]; other site 523796004906 putative Mg++ binding site [ion binding]; other site 523796004907 hypothetical protein; Provisional; Region: PRK13665 523796004908 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 523796004909 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 523796004910 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 523796004911 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 523796004912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796004913 FeS/SAM binding site; other site 523796004914 TRAM domain; Region: TRAM; cl01282 523796004915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 523796004916 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 523796004917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796004918 S-adenosylmethionine binding site [chemical binding]; other site 523796004919 chaperone protein DnaJ; Provisional; Region: PRK14280 523796004920 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 523796004921 HSP70 interaction site [polypeptide binding]; other site 523796004922 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 523796004923 substrate binding site [polypeptide binding]; other site 523796004924 dimer interface [polypeptide binding]; other site 523796004925 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 523796004926 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 523796004927 nucleotide binding site [chemical binding]; other site 523796004928 NEF interaction site [polypeptide binding]; other site 523796004929 SBD interface [polypeptide binding]; other site 523796004930 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 523796004931 dimer interface [polypeptide binding]; other site 523796004932 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 523796004933 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 523796004934 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 523796004935 HrcA protein C terminal domain; Region: HrcA; pfam01628 523796004936 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 523796004937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796004938 FeS/SAM binding site; other site 523796004939 HemN C-terminal domain; Region: HemN_C; pfam06969 523796004940 GTP-binding protein LepA; Provisional; Region: PRK05433 523796004941 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 523796004942 G1 box; other site 523796004943 putative GEF interaction site [polypeptide binding]; other site 523796004944 GTP/Mg2+ binding site [chemical binding]; other site 523796004945 Switch I region; other site 523796004946 G2 box; other site 523796004947 G3 box; other site 523796004948 Switch II region; other site 523796004949 G4 box; other site 523796004950 G5 box; other site 523796004951 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 523796004952 Elongation Factor G, domain II; Region: EFG_II; pfam14492 523796004953 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 523796004954 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 523796004955 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 523796004956 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 523796004957 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 523796004958 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 523796004959 Competence protein; Region: Competence; pfam03772 523796004960 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 523796004961 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523796004962 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 523796004963 catalytic motif [active] 523796004964 Zn binding site [ion binding]; other site 523796004965 SLBB domain; Region: SLBB; pfam10531 523796004966 comEA protein; Region: comE; TIGR01259 523796004967 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 523796004968 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523796004969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796004970 S-adenosylmethionine binding site [chemical binding]; other site 523796004971 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 523796004972 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523796004973 Zn2+ binding site [ion binding]; other site 523796004974 Mg2+ binding site [ion binding]; other site 523796004975 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 523796004976 active site 523796004977 (T/H)XGH motif; other site 523796004978 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 523796004979 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 523796004980 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 523796004981 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 523796004982 shikimate binding site; other site 523796004983 NAD(P) binding site [chemical binding]; other site 523796004984 GTPase YqeH; Provisional; Region: PRK13796 523796004985 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 523796004986 GTP/Mg2+ binding site [chemical binding]; other site 523796004987 G4 box; other site 523796004988 G5 box; other site 523796004989 G1 box; other site 523796004990 Switch I region; other site 523796004991 G2 box; other site 523796004992 G3 box; other site 523796004993 Switch II region; other site 523796004994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796004995 active site 523796004996 motif I; other site 523796004997 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 523796004998 motif II; other site 523796004999 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 523796005000 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 523796005001 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 523796005002 Fic family protein [Function unknown]; Region: COG3177 523796005003 Fic/DOC family; Region: Fic; pfam02661 523796005004 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 523796005005 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 523796005006 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 523796005007 putative active site [active] 523796005008 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523796005009 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 523796005010 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523796005011 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 523796005012 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 523796005013 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 523796005014 carboxyltransferase (CT) interaction site; other site 523796005015 biotinylation site [posttranslational modification]; other site 523796005016 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 523796005017 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 523796005018 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 523796005019 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 523796005020 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 523796005021 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 523796005022 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 523796005023 Sugar specificity; other site 523796005024 Pyrimidine base specificity; other site 523796005025 ATP-binding site [chemical binding]; other site 523796005026 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 523796005027 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 523796005028 Peptidase family U32; Region: Peptidase_U32; pfam01136 523796005029 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 523796005030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796005031 S-adenosylmethionine binding site [chemical binding]; other site 523796005032 hypothetical protein; Provisional; Region: PRK13678 523796005033 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 523796005034 hypothetical protein; Provisional; Region: PRK05473 523796005035 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 523796005036 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 523796005037 motif 1; other site 523796005038 active site 523796005039 motif 2; other site 523796005040 motif 3; other site 523796005041 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 523796005042 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 523796005043 DHHA1 domain; Region: DHHA1; pfam02272 523796005044 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 523796005045 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 523796005046 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 523796005047 AAA domain; Region: AAA_30; pfam13604 523796005048 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 523796005049 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523796005050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523796005051 binding surface 523796005052 TPR motif; other site 523796005053 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 523796005054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523796005055 binding surface 523796005056 TPR motif; other site 523796005057 TPR repeat; Region: TPR_11; pfam13414 523796005058 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 523796005059 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 523796005060 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 523796005061 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 523796005062 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523796005063 catalytic residue [active] 523796005064 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 523796005065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 523796005066 Predicted transcriptional regulator [Transcription]; Region: COG1959 523796005067 Rrf2 family protein; Region: rrf2_super; TIGR00738 523796005068 recombination factor protein RarA; Reviewed; Region: PRK13342 523796005069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796005070 Walker A motif; other site 523796005071 ATP binding site [chemical binding]; other site 523796005072 Walker B motif; other site 523796005073 arginine finger; other site 523796005074 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 523796005075 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 523796005076 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 523796005077 putative ATP binding site [chemical binding]; other site 523796005078 putative substrate interface [chemical binding]; other site 523796005079 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 523796005080 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 523796005081 dimer interface [polypeptide binding]; other site 523796005082 anticodon binding site; other site 523796005083 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 523796005084 homodimer interface [polypeptide binding]; other site 523796005085 motif 1; other site 523796005086 active site 523796005087 motif 2; other site 523796005088 motif 3; other site 523796005089 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 523796005090 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 523796005091 dimer interface [polypeptide binding]; other site 523796005092 motif 1; other site 523796005093 active site 523796005094 motif 2; other site 523796005095 motif 3; other site 523796005096 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 523796005097 anticodon binding site; other site 523796005098 Bacterial SH3 domain homologues; Region: SH3b; smart00287 523796005099 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 523796005100 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 523796005101 active site 523796005102 metal binding site [ion binding]; metal-binding site 523796005103 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 523796005104 putative active site [active] 523796005105 dimerization interface [polypeptide binding]; other site 523796005106 putative tRNAtyr binding site [nucleotide binding]; other site 523796005107 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 523796005108 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523796005109 Zn2+ binding site [ion binding]; other site 523796005110 Mg2+ binding site [ion binding]; other site 523796005111 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 523796005112 synthetase active site [active] 523796005113 NTP binding site [chemical binding]; other site 523796005114 metal binding site [ion binding]; metal-binding site 523796005115 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 523796005116 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 523796005117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796005118 active site 523796005119 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 523796005120 DHH family; Region: DHH; pfam01368 523796005121 DHHA1 domain; Region: DHHA1; pfam02272 523796005122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 523796005123 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 523796005124 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 523796005125 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 523796005126 Protein export membrane protein; Region: SecD_SecF; pfam02355 523796005127 Preprotein translocase subunit; Region: YajC; pfam02699 523796005128 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 523796005129 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 523796005130 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 523796005131 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 523796005132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796005133 Walker A motif; other site 523796005134 ATP binding site [chemical binding]; other site 523796005135 Walker B motif; other site 523796005136 arginine finger; other site 523796005137 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 523796005138 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 523796005139 RuvA N terminal domain; Region: RuvA_N; pfam01330 523796005140 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 523796005141 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 523796005142 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 523796005143 GTPase CgtA; Reviewed; Region: obgE; PRK12297 523796005144 GTP1/OBG; Region: GTP1_OBG; pfam01018 523796005145 Obg GTPase; Region: Obg; cd01898 523796005146 G1 box; other site 523796005147 GTP/Mg2+ binding site [chemical binding]; other site 523796005148 Switch I region; other site 523796005149 G2 box; other site 523796005150 G3 box; other site 523796005151 Switch II region; other site 523796005152 G4 box; other site 523796005153 G5 box; other site 523796005154 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 523796005155 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 523796005156 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 523796005157 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 523796005158 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 523796005159 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 523796005160 hypothetical protein; Reviewed; Region: PRK00024 523796005161 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 523796005162 MPN+ (JAMM) motif; other site 523796005163 Zinc-binding site [ion binding]; other site 523796005164 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 523796005165 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 523796005166 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 523796005167 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 523796005168 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523796005169 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523796005170 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 523796005171 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 523796005172 active site 523796005173 HIGH motif; other site 523796005174 KMSKS motif; other site 523796005175 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 523796005176 tRNA binding surface [nucleotide binding]; other site 523796005177 anticodon binding site; other site 523796005178 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 523796005179 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 523796005180 Putative ammonia monooxygenase; Region: AmoA; pfam05145 523796005181 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 523796005182 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 523796005183 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 523796005184 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523796005185 inhibitor-cofactor binding pocket; inhibition site 523796005186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796005187 catalytic residue [active] 523796005188 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 523796005189 dimer interface [polypeptide binding]; other site 523796005190 active site 523796005191 Schiff base residues; other site 523796005192 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 523796005193 active site 523796005194 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 523796005195 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 523796005196 domain interfaces; other site 523796005197 active site 523796005198 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 523796005199 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 523796005200 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 523796005201 tRNA; other site 523796005202 putative tRNA binding site [nucleotide binding]; other site 523796005203 putative NADP binding site [chemical binding]; other site 523796005204 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 523796005205 Predicted GTPase [General function prediction only]; Region: COG0218 523796005206 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 523796005207 G1 box; other site 523796005208 GTP/Mg2+ binding site [chemical binding]; other site 523796005209 Switch I region; other site 523796005210 G2 box; other site 523796005211 G3 box; other site 523796005212 Switch II region; other site 523796005213 G4 box; other site 523796005214 G5 box; other site 523796005215 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 523796005216 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 523796005217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796005218 Walker A motif; other site 523796005219 ATP binding site [chemical binding]; other site 523796005220 Walker B motif; other site 523796005221 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 523796005222 trigger factor; Provisional; Region: tig; PRK01490 523796005223 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 523796005224 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 523796005225 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 523796005226 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 523796005227 23S rRNA binding site [nucleotide binding]; other site 523796005228 L21 binding site [polypeptide binding]; other site 523796005229 L13 binding site [polypeptide binding]; other site 523796005230 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 523796005231 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 523796005232 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 523796005233 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 523796005234 lysine transporter; Provisional; Region: PRK10836 523796005235 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 523796005236 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 523796005237 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 523796005238 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 523796005239 active site 523796005240 dimer interface [polypeptide binding]; other site 523796005241 motif 1; other site 523796005242 motif 2; other site 523796005243 motif 3; other site 523796005244 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 523796005245 anticodon binding site; other site 523796005246 primosomal protein DnaI; Reviewed; Region: PRK08939 523796005247 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 523796005248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796005249 Walker A motif; other site 523796005250 ATP binding site [chemical binding]; other site 523796005251 Walker B motif; other site 523796005252 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 523796005253 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 523796005254 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 523796005255 ATP cone domain; Region: ATP-cone; pfam03477 523796005256 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 523796005257 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 523796005258 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 523796005259 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 523796005260 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 523796005261 CoA-binding site [chemical binding]; other site 523796005262 ATP-binding [chemical binding]; other site 523796005263 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 523796005264 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 523796005265 DNA binding site [nucleotide binding] 523796005266 catalytic residue [active] 523796005267 H2TH interface [polypeptide binding]; other site 523796005268 putative catalytic residues [active] 523796005269 turnover-facilitating residue; other site 523796005270 intercalation triad [nucleotide binding]; other site 523796005271 8OG recognition residue [nucleotide binding]; other site 523796005272 putative reading head residues; other site 523796005273 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 523796005274 DNA polymerase I; Provisional; Region: PRK05755 523796005275 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 523796005276 active site 523796005277 metal binding site 1 [ion binding]; metal-binding site 523796005278 putative 5' ssDNA interaction site; other site 523796005279 metal binding site 3; metal-binding site 523796005280 metal binding site 2 [ion binding]; metal-binding site 523796005281 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 523796005282 putative DNA binding site [nucleotide binding]; other site 523796005283 putative metal binding site [ion binding]; other site 523796005284 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 523796005285 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 523796005286 active site 523796005287 DNA binding site [nucleotide binding] 523796005288 catalytic site [active] 523796005289 HAMP domain; Region: HAMP; pfam00672 523796005290 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 523796005291 PAS domain; Region: PAS_8; pfam13188 523796005292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523796005293 dimer interface [polypeptide binding]; other site 523796005294 phosphorylation site [posttranslational modification] 523796005295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796005296 ATP binding site [chemical binding]; other site 523796005297 Mg2+ binding site [ion binding]; other site 523796005298 G-X-G motif; other site 523796005299 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523796005300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796005301 active site 523796005302 phosphorylation site [posttranslational modification] 523796005303 intermolecular recognition site; other site 523796005304 dimerization interface [polypeptide binding]; other site 523796005305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523796005306 DNA binding site [nucleotide binding] 523796005307 isocitrate dehydrogenase; Reviewed; Region: PRK07006 523796005308 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 523796005309 dimer interface [polypeptide binding]; other site 523796005310 Citrate synthase; Region: Citrate_synt; pfam00285 523796005311 active site 523796005312 citrylCoA binding site [chemical binding]; other site 523796005313 oxalacetate/citrate binding site [chemical binding]; other site 523796005314 coenzyme A binding site [chemical binding]; other site 523796005315 catalytic triad [active] 523796005316 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 523796005317 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 523796005318 pyruvate kinase; Provisional; Region: PRK06354 523796005319 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 523796005320 domain interfaces; other site 523796005321 active site 523796005322 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 523796005323 6-phosphofructokinase; Provisional; Region: PRK03202 523796005324 active site 523796005325 ADP/pyrophosphate binding site [chemical binding]; other site 523796005326 dimerization interface [polypeptide binding]; other site 523796005327 allosteric effector site; other site 523796005328 fructose-1,6-bisphosphate binding site; other site 523796005329 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 523796005330 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 523796005331 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 523796005332 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 523796005333 Malic enzyme, N-terminal domain; Region: malic; pfam00390 523796005334 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 523796005335 putative NAD(P) binding site [chemical binding]; other site 523796005336 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 523796005337 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 523796005338 active site 523796005339 PHP Thumb interface [polypeptide binding]; other site 523796005340 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 523796005341 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 523796005342 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 523796005343 generic binding surface I; other site 523796005344 generic binding surface II; other site 523796005345 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 523796005346 DHH family; Region: DHH; pfam01368 523796005347 DHHA1 domain; Region: DHHA1; pfam02272 523796005348 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 523796005349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 523796005350 DNA-binding site [nucleotide binding]; DNA binding site 523796005351 DRTGG domain; Region: DRTGG; pfam07085 523796005352 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 523796005353 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 523796005354 active site 2 [active] 523796005355 active site 1 [active] 523796005356 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 523796005357 Ligand Binding Site [chemical binding]; other site 523796005358 metal-dependent hydrolase; Provisional; Region: PRK00685 523796005359 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 523796005360 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 523796005361 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 523796005362 active site 523796005363 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 523796005364 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 523796005365 hexamer interface [polypeptide binding]; other site 523796005366 ligand binding site [chemical binding]; other site 523796005367 putative active site [active] 523796005368 NAD(P) binding site [chemical binding]; other site 523796005369 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 523796005370 Ligand Binding Site [chemical binding]; other site 523796005371 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 523796005372 propionate/acetate kinase; Provisional; Region: PRK12379 523796005373 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 523796005374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796005375 S-adenosylmethionine binding site [chemical binding]; other site 523796005376 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 523796005377 dimer interface [polypeptide binding]; other site 523796005378 catalytic triad [active] 523796005379 peroxidatic and resolving cysteines [active] 523796005380 hypothetical protein; Provisional; Region: PRK10621 523796005381 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 523796005382 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 523796005383 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 523796005384 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 523796005385 Ligand Binding Site [chemical binding]; other site 523796005386 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 523796005387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523796005388 catalytic residue [active] 523796005389 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 523796005390 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 523796005391 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 523796005392 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 523796005393 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523796005394 RNA binding surface [nucleotide binding]; other site 523796005395 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 523796005396 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 523796005397 active site 523796005398 catalytic site [active] 523796005399 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 523796005400 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 523796005401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523796005402 catalytic residue [active] 523796005403 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 523796005404 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 523796005405 ligand binding site [chemical binding]; other site 523796005406 NAD binding site [chemical binding]; other site 523796005407 dimerization interface [polypeptide binding]; other site 523796005408 catalytic site [active] 523796005409 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 523796005410 putative L-serine binding site [chemical binding]; other site 523796005411 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 523796005412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796005413 motif II; other site 523796005414 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 523796005415 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523796005416 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523796005417 active site turn [active] 523796005418 phosphorylation site [posttranslational modification] 523796005419 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 523796005420 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 523796005421 putative acyl-acceptor binding pocket; other site 523796005422 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 523796005423 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 523796005424 protein binding site [polypeptide binding]; other site 523796005425 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 523796005426 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 523796005427 active site 523796005428 HIGH motif; other site 523796005429 dimer interface [polypeptide binding]; other site 523796005430 KMSKS motif; other site 523796005431 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523796005432 RNA binding surface [nucleotide binding]; other site 523796005433 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 523796005434 Transglycosylase; Region: Transgly; pfam00912 523796005435 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 523796005436 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 523796005437 NEAr Transporter domain; Region: NEAT; smart00725 523796005438 NEAr Transporter domain; Region: NEAT; smart00725 523796005439 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 523796005440 heme-binding site [chemical binding]; other site 523796005441 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 523796005442 Potassium binding sites [ion binding]; other site 523796005443 Cesium cation binding sites [ion binding]; other site 523796005444 acetyl-CoA synthetase; Provisional; Region: PRK04319 523796005445 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 523796005446 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 523796005447 active site 523796005448 acyl-activating enzyme (AAE) consensus motif; other site 523796005449 putative CoA binding site [chemical binding]; other site 523796005450 AMP binding site [chemical binding]; other site 523796005451 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 523796005452 active site 523796005453 Zn binding site [ion binding]; other site 523796005454 catabolite control protein A; Region: ccpA; TIGR01481 523796005455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 523796005456 DNA binding site [nucleotide binding] 523796005457 domain linker motif; other site 523796005458 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 523796005459 dimerization interface [polypeptide binding]; other site 523796005460 effector binding site; other site 523796005461 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 523796005462 Chorismate mutase type II; Region: CM_2; cl00693 523796005463 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 523796005464 electron transport complex protein RnfC; Provisional; Region: PRK05035 523796005465 Transmembrane protein; Region: Macoilin; pfam09726 523796005466 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 523796005467 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 523796005468 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523796005469 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523796005470 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523796005471 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 523796005472 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523796005473 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 523796005474 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 523796005475 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 523796005476 putative tRNA-binding site [nucleotide binding]; other site 523796005477 hypothetical protein; Provisional; Region: PRK13668 523796005478 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523796005479 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523796005480 catalytic residues [active] 523796005481 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 523796005482 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 523796005483 oligomer interface [polypeptide binding]; other site 523796005484 active site 523796005485 metal binding site [ion binding]; metal-binding site 523796005486 Predicted small secreted protein [Function unknown]; Region: COG5584 523796005487 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 523796005488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796005489 S-adenosylmethionine binding site [chemical binding]; other site 523796005490 Phosphotransferase enzyme family; Region: APH; pfam01636 523796005491 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 523796005492 active site 523796005493 substrate binding site [chemical binding]; other site 523796005494 ATP binding site [chemical binding]; other site 523796005495 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 523796005496 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 523796005497 homodimer interface [polypeptide binding]; other site 523796005498 substrate-cofactor binding pocket; other site 523796005499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796005500 catalytic residue [active] 523796005501 dipeptidase PepV; Reviewed; Region: PRK07318 523796005502 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 523796005503 active site 523796005504 metal binding site [ion binding]; metal-binding site 523796005505 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 523796005506 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523796005507 RNA binding surface [nucleotide binding]; other site 523796005508 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 523796005509 active site 523796005510 uracil binding [chemical binding]; other site 523796005511 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 523796005512 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 523796005513 HI0933-like protein; Region: HI0933_like; pfam03486 523796005514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796005515 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796005516 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 523796005517 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 523796005518 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005519 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005520 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005521 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005522 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005523 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005524 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005525 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005526 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005527 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005528 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005529 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005530 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005531 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005532 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005533 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005534 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796005535 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523796005536 active site residue [active] 523796005537 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 523796005538 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 523796005539 active site 523796005540 HIGH motif; other site 523796005541 KMSKS motif; other site 523796005542 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 523796005543 tRNA binding surface [nucleotide binding]; other site 523796005544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796005545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796005546 putative substrate translocation pore; other site 523796005547 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 523796005548 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523796005549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796005550 S-adenosylmethionine binding site [chemical binding]; other site 523796005551 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 523796005552 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 523796005553 Putative lysophospholipase; Region: Hydrolase_4; cl19140 523796005554 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 523796005555 Proline dehydrogenase; Region: Pro_dh; pfam01619 523796005556 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 523796005557 homopentamer interface [polypeptide binding]; other site 523796005558 active site 523796005559 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 523796005560 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 523796005561 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 523796005562 dimerization interface [polypeptide binding]; other site 523796005563 active site 523796005564 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 523796005565 Lumazine binding domain; Region: Lum_binding; pfam00677 523796005566 Lumazine binding domain; Region: Lum_binding; pfam00677 523796005567 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 523796005568 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 523796005569 catalytic motif [active] 523796005570 Zn binding site [ion binding]; other site 523796005571 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 523796005572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 523796005573 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 523796005574 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 523796005575 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 523796005576 transmembrane helices; other site 523796005577 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 523796005578 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 523796005579 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 523796005580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523796005581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 523796005582 DNA binding residues [nucleotide binding] 523796005583 CAAX protease self-immunity; Region: Abi; pfam02517 523796005584 CAAX protease self-immunity; Region: Abi; pfam02517 523796005585 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 523796005586 active site 523796005587 intersubunit interactions; other site 523796005588 catalytic residue [active] 523796005589 camphor resistance protein CrcB; Provisional; Region: PRK14201 523796005590 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 523796005591 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 523796005592 active site 523796005593 catalytic tetrad [active] 523796005594 S-adenosylmethionine synthetase; Validated; Region: PRK05250 523796005595 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 523796005596 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 523796005597 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 523796005598 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 523796005599 active site 523796005600 substrate-binding site [chemical binding]; other site 523796005601 metal-binding site [ion binding] 523796005602 ATP binding site [chemical binding]; other site 523796005603 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 523796005604 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 523796005605 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 523796005606 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 523796005607 nudix motif; other site 523796005608 Haemolytic domain; Region: Haemolytic; pfam01809 523796005609 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 523796005610 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 523796005611 metal binding site [ion binding]; metal-binding site 523796005612 substrate binding pocket [chemical binding]; other site 523796005613 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 523796005614 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 523796005615 acyl-activating enzyme (AAE) consensus motif; other site 523796005616 putative AMP binding site [chemical binding]; other site 523796005617 putative active site [active] 523796005618 putative CoA binding site [chemical binding]; other site 523796005619 Integrase core domain; Region: rve; pfam00665 523796005620 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 523796005621 Integrase core domain; Region: rve_3; cl15866 523796005622 Helix-turn-helix domain; Region: HTH_38; pfam13936 523796005623 Winged helix-turn helix; Region: HTH_29; pfam13551 523796005624 Homeodomain-like domain; Region: HTH_32; pfam13565 523796005625 Domain of unknown function with cystatin-like fold (DUF4467); Region: DUF4467; pfam14729 523796005626 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 523796005627 Surface antigen [General function prediction only]; Region: COG3942 523796005628 CHAP domain; Region: CHAP; pfam05257 523796005629 Granin (chromogranin or secretogranin); Region: Granin; pfam01271 523796005630 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523796005631 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 523796005632 Protein of unknown function (DUF4446); Region: DUF4446; pfam14584 523796005633 AAA-like domain; Region: AAA_10; pfam12846 523796005634 Domain of unknown function DUF87; Region: DUF87; cl19135 523796005635 TcpE family; Region: TcpE; pfam12648 523796005636 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 523796005637 Replication initiation factor; Region: Rep_trans; pfam02486 523796005638 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 523796005639 Excalibur calcium-binding domain; Region: Excalibur; smart00894 523796005640 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 523796005641 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 523796005642 Domain of unknown function (DUF955); Region: DUF955; pfam06114 523796005643 HTH-like domain; Region: HTH_21; pfam13276 523796005644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 523796005645 Transposase; Region: HTH_Tnp_1; pfam01527 523796005646 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796005647 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796005648 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796005649 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 523796005650 substrate binding site [chemical binding]; other site 523796005651 catalytic residues [active] 523796005652 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796005653 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796005654 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 523796005655 nucleophilic elbow; other site 523796005656 catalytic triad; other site 523796005657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796005658 Walker A motif; other site 523796005659 ATP binding site [chemical binding]; other site 523796005660 Walker B motif; other site 523796005661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 523796005662 Integrase core domain; Region: rve; pfam00665 523796005663 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 523796005664 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 523796005665 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 523796005666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 523796005667 ferrochelatase; Provisional; Region: PRK12435 523796005668 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 523796005669 C-terminal domain interface [polypeptide binding]; other site 523796005670 active site 523796005671 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 523796005672 active site 523796005673 N-terminal domain interface [polypeptide binding]; other site 523796005674 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 523796005675 substrate binding site [chemical binding]; other site 523796005676 active site 523796005677 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 523796005678 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 523796005679 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 523796005680 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 523796005681 Walker A/P-loop; other site 523796005682 ATP binding site [chemical binding]; other site 523796005683 Q-loop/lid; other site 523796005684 ABC transporter signature motif; other site 523796005685 Walker B; other site 523796005686 D-loop; other site 523796005687 H-loop/switch region; other site 523796005688 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 523796005689 HIT family signature motif; other site 523796005690 catalytic residue [active] 523796005691 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 523796005692 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 523796005693 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 523796005694 SurA N-terminal domain; Region: SurA_N_3; cl07813 523796005695 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 523796005696 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 523796005697 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 523796005698 generic binding surface II; other site 523796005699 generic binding surface I; other site 523796005700 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523796005701 Zn2+ binding site [ion binding]; other site 523796005702 Mg2+ binding site [ion binding]; other site 523796005703 Uncharacterized conserved protein [Function unknown]; Region: COG4717 523796005704 AAA domain; Region: AAA_23; pfam13476 523796005705 Walker A/P-loop; other site 523796005706 ATP binding site [chemical binding]; other site 523796005707 Peptidase family M48; Region: Peptidase_M48; cl12018 523796005708 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 523796005709 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 523796005710 active site 523796005711 metal binding site [ion binding]; metal-binding site 523796005712 DNA binding site [nucleotide binding] 523796005713 hypothetical protein; Provisional; Region: PRK13676 523796005714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 523796005715 Protein of unknown function (DUF445); Region: DUF445; pfam04286 523796005716 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523796005717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796005718 non-specific DNA binding site [nucleotide binding]; other site 523796005719 salt bridge; other site 523796005720 sequence-specific DNA binding site [nucleotide binding]; other site 523796005721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 523796005722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796005723 active site 523796005724 phosphorylation site [posttranslational modification] 523796005725 intermolecular recognition site; other site 523796005726 dimerization interface [polypeptide binding]; other site 523796005727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 523796005728 DNA binding residues [nucleotide binding] 523796005729 dimerization interface [polypeptide binding]; other site 523796005730 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 523796005731 GAF domain; Region: GAF_3; pfam13492 523796005732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 523796005733 Histidine kinase; Region: HisKA_3; pfam07730 523796005734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796005735 ATP binding site [chemical binding]; other site 523796005736 Mg2+ binding site [ion binding]; other site 523796005737 G-X-G motif; other site 523796005738 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 523796005739 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523796005740 active site 523796005741 fumarate hydratase; Reviewed; Region: fumC; PRK00485 523796005742 Class II fumarases; Region: Fumarase_classII; cd01362 523796005743 active site 523796005744 tetramer interface [polypeptide binding]; other site 523796005745 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 523796005746 active site 523796005747 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 523796005748 epoxyqueuosine reductase; Region: TIGR00276 523796005749 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 523796005750 HEAT repeats; Region: HEAT_2; pfam13646 523796005751 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 523796005752 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 523796005753 Walker A/P-loop; other site 523796005754 ATP binding site [chemical binding]; other site 523796005755 Q-loop/lid; other site 523796005756 ABC transporter signature motif; other site 523796005757 Walker B; other site 523796005758 D-loop; other site 523796005759 H-loop/switch region; other site 523796005760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523796005761 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523796005762 substrate binding pocket [chemical binding]; other site 523796005763 membrane-bound complex binding site; other site 523796005764 hinge residues; other site 523796005765 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 523796005766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796005767 dimer interface [polypeptide binding]; other site 523796005768 conserved gate region; other site 523796005769 putative PBP binding loops; other site 523796005770 ABC-ATPase subunit interface; other site 523796005771 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 523796005772 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 523796005774 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 523796005775 metal binding site 2 [ion binding]; metal-binding site 523796005776 putative DNA binding helix; other site 523796005777 metal binding site 1 [ion binding]; metal-binding site 523796005778 dimer interface [polypeptide binding]; other site 523796005779 structural Zn2+ binding site [ion binding]; other site 523796005780 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 523796005781 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 523796005782 putative ligand binding site [chemical binding]; other site 523796005783 NAD binding site [chemical binding]; other site 523796005784 catalytic site [active] 523796005785 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 523796005786 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 523796005787 catalytic triad [active] 523796005788 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 523796005789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523796005790 inhibitor-cofactor binding pocket; inhibition site 523796005791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796005792 catalytic residue [active] 523796005793 Predicted membrane protein [Function unknown]; Region: COG4129 523796005794 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 523796005795 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 523796005796 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523796005797 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 523796005798 Walker A/P-loop; other site 523796005799 ATP binding site [chemical binding]; other site 523796005800 Q-loop/lid; other site 523796005801 ABC transporter signature motif; other site 523796005802 Walker B; other site 523796005803 D-loop; other site 523796005804 H-loop/switch region; other site 523796005805 hypothetical protein; Provisional; Region: PRK13662 523796005806 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 523796005807 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 523796005808 minor groove reading motif; other site 523796005809 helix-hairpin-helix signature motif; other site 523796005810 substrate binding pocket [chemical binding]; other site 523796005811 active site 523796005812 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 523796005813 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 523796005814 DNA binding and oxoG recognition site [nucleotide binding] 523796005815 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 523796005816 ABC-2 type transporter; Region: ABC2_membrane; cl17235 523796005817 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 523796005818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796005819 Walker A/P-loop; other site 523796005820 ATP binding site [chemical binding]; other site 523796005821 Q-loop/lid; other site 523796005822 ABC transporter signature motif; other site 523796005823 Walker B; other site 523796005824 H-loop/switch region; other site 523796005825 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 523796005826 recombination regulator RecX; Provisional; Region: recX; PRK14135 523796005827 glycosyltransferase; Provisional; Region: PRK13481 523796005828 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 523796005829 intracellular protease, PfpI family; Region: PfpI; TIGR01382 523796005830 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 523796005831 proposed catalytic triad [active] 523796005832 conserved cys residue [active] 523796005833 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 523796005834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796005835 FeS/SAM binding site; other site 523796005836 YfkB-like domain; Region: YfkB; pfam08756 523796005837 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 523796005838 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 523796005839 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 523796005840 Low molecular weight phosphatase family; Region: LMWPc; cd00115 523796005841 active site 523796005842 YtxH-like protein; Region: YtxH; pfam12732 523796005843 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 523796005844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 523796005845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796005846 active site 523796005847 phosphorylation site [posttranslational modification] 523796005848 intermolecular recognition site; other site 523796005849 dimerization interface [polypeptide binding]; other site 523796005850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 523796005851 DNA binding residues [nucleotide binding] 523796005852 dimerization interface [polypeptide binding]; other site 523796005853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 523796005854 Histidine kinase; Region: HisKA_3; pfam07730 523796005855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796005856 ATP binding site [chemical binding]; other site 523796005857 Mg2+ binding site [ion binding]; other site 523796005858 G-X-G motif; other site 523796005859 Predicted membrane protein [Function unknown]; Region: COG4758 523796005860 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 523796005861 active site 523796005862 Predicted membrane protein [Function unknown]; Region: COG4129 523796005863 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 523796005864 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 523796005865 catalytic triad [active] 523796005866 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 523796005867 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523796005868 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 523796005869 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 523796005870 Ferritin-like domain; Region: Ferritin; pfam00210 523796005871 ferroxidase diiron center [ion binding]; other site 523796005872 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 523796005873 active site 523796005874 catalytic site [active] 523796005875 substrate binding site [chemical binding]; other site 523796005876 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 523796005877 active site 523796005878 DNA polymerase IV; Validated; Region: PRK02406 523796005879 DNA binding site [nucleotide binding] 523796005880 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 523796005881 TRAM domain; Region: TRAM; cl01282 523796005882 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 523796005883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796005884 S-adenosylmethionine binding site [chemical binding]; other site 523796005885 putative lipid kinase; Reviewed; Region: PRK13337 523796005886 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 523796005887 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 523796005888 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 523796005889 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 523796005890 GatB domain; Region: GatB_Yqey; pfam02637 523796005891 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 523796005892 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 523796005893 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 523796005894 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 523796005895 Na binding site [ion binding]; other site 523796005896 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 523796005897 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 523796005898 putative dimer interface [polypeptide binding]; other site 523796005899 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 523796005900 putative dimer interface [polypeptide binding]; other site 523796005901 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 523796005902 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 523796005903 nucleotide binding pocket [chemical binding]; other site 523796005904 K-X-D-G motif; other site 523796005905 catalytic site [active] 523796005906 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 523796005907 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 523796005908 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 523796005909 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 523796005910 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 523796005911 Dimer interface [polypeptide binding]; other site 523796005912 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 523796005913 Part of AAA domain; Region: AAA_19; pfam13245 523796005914 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 523796005915 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 523796005916 substrate binding site [chemical binding]; other site 523796005917 putative active site [active] 523796005918 dimer interface [polypeptide binding]; other site 523796005919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 523796005920 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 523796005921 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 523796005922 tetramer interface [polypeptide binding]; other site 523796005923 active site 523796005924 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 523796005925 Staphopain proregion; Region: Staphopain_pro; pfam14731 523796005926 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 523796005927 Staphostatin A; Region: Staphostatin_A; pfam09022 523796005928 NETI protein; Region: NETI; pfam14044 523796005929 hypothetical protein; Provisional; Region: PRK04164 523796005930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 523796005931 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 523796005932 homodimer interface [polypeptide binding]; other site 523796005933 NAD binding pocket [chemical binding]; other site 523796005934 ATP binding pocket [chemical binding]; other site 523796005935 Mg binding site [ion binding]; other site 523796005936 active-site loop [active] 523796005937 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 523796005938 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 523796005939 active site 523796005940 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 523796005941 active site 523796005942 dimer interface [polypeptide binding]; other site 523796005943 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 523796005944 Prephenate dehydratase; Region: PDT; pfam00800 523796005945 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 523796005946 putative L-Phe binding site [chemical binding]; other site 523796005947 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 523796005948 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 523796005949 transmembrane helices; other site 523796005950 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 523796005951 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 523796005952 Isochorismatase family; Region: Isochorismatase; pfam00857 523796005953 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 523796005954 catalytic triad [active] 523796005955 conserved cis-peptide bond; other site 523796005956 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 523796005957 DHH family; Region: DHH; pfam01368 523796005958 DHHA2 domain; Region: DHHA2; pfam02833 523796005959 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 523796005960 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 523796005961 NAD(P) binding site [chemical binding]; other site 523796005962 catalytic residues [active] 523796005963 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 523796005964 Predicted transcriptional regulator [Transcription]; Region: COG3682 523796005965 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 523796005966 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 523796005967 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 523796005968 YolD-like protein; Region: YolD; pfam08863 523796005969 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 523796005970 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 523796005971 Int/Topo IB signature motif; other site 523796005972 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 523796005973 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 523796005974 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 523796005975 Int/Topo IB signature motif; other site 523796005976 YolD-like protein; Region: YolD; pfam08863 523796005977 Predicted choloylglycine hydrolase [General function prediction only]; Region: COG4927 523796005978 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 523796005979 active site 523796005980 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 523796005981 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 523796005982 Integrase core domain; Region: rve; pfam00665 523796005983 Integrase core domain; Region: rve_3; cl15866 523796005984 Winged helix-turn helix; Region: HTH_29; pfam13551 523796005985 Homeodomain-like domain; Region: HTH_32; pfam13565 523796005986 Domain of unknown function with cystatin-like fold (DUF4467); Region: DUF4467; pfam14729 523796005987 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 523796005988 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 523796005989 Surface antigen [General function prediction only]; Region: COG3942 523796005990 CHAP domain; Region: CHAP; pfam05257 523796005991 Acyltransferase family; Region: Acyl_transf_3; cl19154 523796005992 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523796005993 AAA-like domain; Region: AAA_10; pfam12846 523796005994 TcpE family; Region: TcpE; pfam12648 523796005995 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 523796005996 Replication initiation factor; Region: Rep_trans; pfam02486 523796005997 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 523796005998 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 523796005999 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 523796006000 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 523796006001 Bacterial PH domain; Region: bPH_2; cl01348 523796006002 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 523796006003 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 523796006004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796006005 Walker A/P-loop; other site 523796006006 ATP binding site [chemical binding]; other site 523796006007 Q-loop/lid; other site 523796006008 ABC transporter signature motif; other site 523796006009 Walker B; other site 523796006010 D-loop; other site 523796006011 H-loop/switch region; other site 523796006012 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 523796006013 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 523796006014 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 523796006015 Walker A/P-loop; other site 523796006016 ATP binding site [chemical binding]; other site 523796006017 Q-loop/lid; other site 523796006018 ABC transporter signature motif; other site 523796006019 Walker B; other site 523796006020 D-loop; other site 523796006021 H-loop/switch region; other site 523796006022 Predicted transcriptional regulators [Transcription]; Region: COG1725 523796006023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523796006024 DNA-binding site [nucleotide binding]; DNA binding site 523796006025 hypothetical protein; Provisional; Region: PRK08637 523796006026 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523796006027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796006028 homodimer interface [polypeptide binding]; other site 523796006029 catalytic residue [active] 523796006030 MAP domain; Region: MAP; pfam03642 523796006031 MAP domain; Region: MAP; pfam03642 523796006032 MAP domain; Region: MAP; pfam03642 523796006033 MAP domain; Region: MAP; pfam03642 523796006034 MAP domain; Region: MAP; pfam03642 523796006035 MAP domain; Region: MAP; pfam03642 523796006036 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 523796006037 putative catalytic site [active] 523796006038 metal binding site A [ion binding]; metal-binding site 523796006039 phosphate binding site [ion binding]; other site 523796006040 metal binding site C [ion binding]; metal-binding site 523796006041 metal binding site B [ion binding]; metal-binding site 523796006042 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 523796006043 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 523796006044 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 523796006045 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 523796006046 metal binding site [ion binding]; metal-binding site 523796006047 dimer interface [polypeptide binding]; other site 523796006048 Cation transport protein; Region: TrkH; cl17365 523796006049 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 523796006050 Cation transport protein; Region: TrkH; cl17365 523796006051 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 523796006052 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 523796006053 ring oligomerisation interface [polypeptide binding]; other site 523796006054 ATP/Mg binding site [chemical binding]; other site 523796006055 stacking interactions; other site 523796006056 hinge regions; other site 523796006057 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 523796006058 oligomerisation interface [polypeptide binding]; other site 523796006059 mobile loop; other site 523796006060 roof hairpin; other site 523796006061 CAAX protease self-immunity; Region: Abi; pfam02517 523796006062 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 523796006063 dimer interface [polypeptide binding]; other site 523796006064 FMN binding site [chemical binding]; other site 523796006065 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 523796006066 putative active site [active] 523796006067 catalytic triad [active] 523796006068 putative dimer interface [polypeptide binding]; other site 523796006069 delta-hemolysin; Provisional; Region: PRK14752 523796006070 Accessory gene regulator B; Region: AgrB; smart00793 523796006071 Staphylococcal AgrD protein; Region: AgrD; smart00794 523796006072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796006073 Mg2+ binding site [ion binding]; other site 523796006074 G-X-G motif; other site 523796006075 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 523796006076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796006077 active site 523796006078 phosphorylation site [posttranslational modification] 523796006079 intermolecular recognition site; other site 523796006080 dimerization interface [polypeptide binding]; other site 523796006081 LytTr DNA-binding domain; Region: LytTR; pfam04397 523796006082 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 523796006083 putative substrate binding site [chemical binding]; other site 523796006084 putative ATP binding site [chemical binding]; other site 523796006085 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 523796006086 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 523796006087 substrate binding [chemical binding]; other site 523796006088 active site 523796006089 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 523796006090 Transcriptional regulators [Transcription]; Region: PurR; COG1609 523796006091 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 523796006092 DNA binding site [nucleotide binding] 523796006093 domain linker motif; other site 523796006094 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 523796006095 dimerization interface [polypeptide binding]; other site 523796006096 ligand binding site [chemical binding]; other site 523796006097 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 523796006098 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 523796006099 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 523796006100 CPxP motif; other site 523796006101 Predicted transporter component [General function prediction only]; Region: COG2391 523796006102 Sulphur transport; Region: Sulf_transp; cl19477 523796006103 Sulphur transport; Region: Sulf_transp; cl19477 523796006104 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 523796006105 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 523796006106 CoA binding domain; Region: CoA_binding; pfam02629 523796006107 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 523796006108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523796006109 ABC transporter; Region: ABC_tran_2; pfam12848 523796006110 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523796006111 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 523796006112 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 523796006113 Walker A/P-loop; other site 523796006114 ATP binding site [chemical binding]; other site 523796006115 Q-loop/lid; other site 523796006116 ABC transporter signature motif; other site 523796006117 Walker B; other site 523796006118 D-loop; other site 523796006119 H-loop/switch region; other site 523796006120 UGMP family protein; Validated; Region: PRK09604 523796006121 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 523796006122 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 523796006123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796006124 Coenzyme A binding pocket [chemical binding]; other site 523796006125 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 523796006126 Glycoprotease family; Region: Peptidase_M22; pfam00814 523796006127 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 523796006128 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 523796006129 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 523796006130 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 523796006131 PYR/PP interface [polypeptide binding]; other site 523796006132 dimer interface [polypeptide binding]; other site 523796006133 TPP binding site [chemical binding]; other site 523796006134 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 523796006135 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 523796006136 TPP-binding site [chemical binding]; other site 523796006137 dimer interface [polypeptide binding]; other site 523796006138 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 523796006139 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 523796006140 ketol-acid reductoisomerase; Provisional; Region: PRK05479 523796006141 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 523796006142 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 523796006143 2-isopropylmalate synthase; Validated; Region: PRK00915 523796006144 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 523796006145 active site 523796006146 catalytic residues [active] 523796006147 metal binding site [ion binding]; metal-binding site 523796006148 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 523796006149 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 523796006150 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 523796006151 substrate binding site [chemical binding]; other site 523796006152 ligand binding site [chemical binding]; other site 523796006153 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 523796006154 substrate binding site [chemical binding]; other site 523796006155 threonine dehydratase; Validated; Region: PRK08639 523796006156 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 523796006157 tetramer interface [polypeptide binding]; other site 523796006158 catalytic residue [active] 523796006159 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 523796006160 putative Ile/Val binding site [chemical binding]; other site 523796006161 hypothetical protein; Provisional; Region: PRK04351 523796006162 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 523796006163 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 523796006164 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 523796006165 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 523796006166 Death-like domain of SPT6; Region: DLD; pfam14878 523796006167 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 523796006168 RNA binding site [nucleotide binding]; other site 523796006169 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 523796006170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523796006171 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 523796006172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523796006173 DNA binding residues [nucleotide binding] 523796006174 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 523796006175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796006176 ATP binding site [chemical binding]; other site 523796006177 Mg2+ binding site [ion binding]; other site 523796006178 G-X-G motif; other site 523796006179 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 523796006180 anti sigma factor interaction site; other site 523796006181 regulatory phosphorylation site [posttranslational modification]; other site 523796006182 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 523796006183 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 523796006184 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 523796006185 PemK-like protein; Region: PemK; pfam02452 523796006186 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 523796006187 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 523796006188 active site 523796006189 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523796006190 dimer interface [polypeptide binding]; other site 523796006191 substrate binding site [chemical binding]; other site 523796006192 catalytic residues [active] 523796006193 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 523796006194 Uncharacterized conserved protein [Function unknown]; Region: COG3402 523796006195 Predicted membrane protein [Function unknown]; Region: COG3428 523796006196 Bacterial PH domain; Region: bPH_2; pfam03703 523796006197 Bacterial PH domain; Region: bPH_2; pfam03703 523796006198 Bacterial PH domain; Region: bPH_2; cl01348 523796006199 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 523796006200 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 523796006201 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523796006202 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 523796006203 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 523796006204 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 523796006205 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 523796006206 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 523796006207 Ligand Binding Site [chemical binding]; other site 523796006208 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 523796006209 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523796006210 dimer interface [polypeptide binding]; other site 523796006211 phosphorylation site [posttranslational modification] 523796006212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796006213 ATP binding site [chemical binding]; other site 523796006214 Mg2+ binding site [ion binding]; other site 523796006215 G-X-G motif; other site 523796006216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523796006217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796006218 active site 523796006219 phosphorylation site [posttranslational modification] 523796006220 intermolecular recognition site; other site 523796006221 dimerization interface [polypeptide binding]; other site 523796006222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523796006223 DNA binding site [nucleotide binding] 523796006224 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 523796006225 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 523796006226 ATP binding site [chemical binding]; other site 523796006227 Mg++ binding site [ion binding]; other site 523796006228 motif III; other site 523796006229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796006230 nucleotide binding region [chemical binding]; other site 523796006231 ATP-binding site [chemical binding]; other site 523796006232 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 523796006233 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523796006234 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523796006235 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523796006236 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 523796006237 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 523796006238 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 523796006239 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 523796006240 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523796006241 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 523796006242 putative homodimer interface [polypeptide binding]; other site 523796006243 putative homotetramer interface [polypeptide binding]; other site 523796006244 allosteric switch controlling residues; other site 523796006245 putative metal binding site [ion binding]; other site 523796006246 putative homodimer-homodimer interface [polypeptide binding]; other site 523796006247 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 523796006248 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 523796006249 putative active site [active] 523796006250 catalytic site [active] 523796006251 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 523796006252 putative active site [active] 523796006253 catalytic site [active] 523796006254 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 523796006255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523796006256 Zn2+ binding site [ion binding]; other site 523796006257 Mg2+ binding site [ion binding]; other site 523796006258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 523796006259 Transposase; Region: DDE_Tnp_ISL3; pfam01610 523796006260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 523796006261 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 523796006262 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 523796006263 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 523796006264 thiamine phosphate binding site [chemical binding]; other site 523796006265 active site 523796006266 pyrophosphate binding site [ion binding]; other site 523796006267 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 523796006268 substrate binding site [chemical binding]; other site 523796006269 multimerization interface [polypeptide binding]; other site 523796006270 ATP binding site [chemical binding]; other site 523796006271 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 523796006272 dimer interface [polypeptide binding]; other site 523796006273 substrate binding site [chemical binding]; other site 523796006274 ATP binding site [chemical binding]; other site 523796006275 thiaminase II; Region: salvage_TenA; TIGR04306 523796006276 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 523796006277 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 523796006278 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 523796006279 dimer interface [polypeptide binding]; other site 523796006280 ssDNA binding site [nucleotide binding]; other site 523796006281 tetramer (dimer of dimers) interface [polypeptide binding]; other site 523796006282 YwpF-like protein; Region: YwpF; pfam14183 523796006283 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 523796006284 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 523796006285 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 523796006286 hinge; other site 523796006287 active site 523796006288 Predicted membrane protein [Function unknown]; Region: COG4836 523796006289 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 523796006290 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 523796006291 gamma subunit interface [polypeptide binding]; other site 523796006292 epsilon subunit interface [polypeptide binding]; other site 523796006293 LBP interface [polypeptide binding]; other site 523796006294 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 523796006295 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 523796006296 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 523796006297 alpha subunit interaction interface [polypeptide binding]; other site 523796006298 Walker A motif; other site 523796006299 ATP binding site [chemical binding]; other site 523796006300 Walker B motif; other site 523796006301 inhibitor binding site; inhibition site 523796006302 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 523796006303 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 523796006304 core domain interface [polypeptide binding]; other site 523796006305 delta subunit interface [polypeptide binding]; other site 523796006306 epsilon subunit interface [polypeptide binding]; other site 523796006307 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 523796006308 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 523796006309 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 523796006310 beta subunit interaction interface [polypeptide binding]; other site 523796006311 Walker A motif; other site 523796006312 ATP binding site [chemical binding]; other site 523796006313 Walker B motif; other site 523796006314 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 523796006315 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 523796006316 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 523796006317 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 523796006318 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 523796006319 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 523796006320 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 523796006321 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 523796006322 active site 523796006323 homodimer interface [polypeptide binding]; other site 523796006324 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523796006325 active site 523796006326 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 523796006327 dimer interface [polypeptide binding]; other site 523796006328 active site 523796006329 glycine-pyridoxal phosphate binding site [chemical binding]; other site 523796006330 folate binding site [chemical binding]; other site 523796006331 hypothetical protein; Provisional; Region: PRK13690 523796006332 Low molecular weight phosphatase family; Region: LMWPc; cd00115 523796006333 active site 523796006334 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 523796006335 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 523796006336 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 523796006337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796006338 S-adenosylmethionine binding site [chemical binding]; other site 523796006339 peptide chain release factor 1; Validated; Region: prfA; PRK00591 523796006340 This domain is found in peptide chain release factors; Region: PCRF; smart00937 523796006341 RF-1 domain; Region: RF-1; pfam00472 523796006342 thymidine kinase; Provisional; Region: PRK04296 523796006343 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 523796006344 transcription termination factor Rho; Provisional; Region: rho; PRK09376 523796006345 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 523796006346 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 523796006347 RNA binding site [nucleotide binding]; other site 523796006348 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 523796006349 multimer interface [polypeptide binding]; other site 523796006350 Walker A motif; other site 523796006351 ATP binding site [chemical binding]; other site 523796006352 Walker B motif; other site 523796006353 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 523796006354 NAD binding site [chemical binding]; other site 523796006355 catalytic residues [active] 523796006356 Predicted transcriptional regulators [Transcription]; Region: COG1733 523796006357 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 523796006358 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 523796006359 hinge; other site 523796006360 active site 523796006361 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 523796006362 intersubunit interface [polypeptide binding]; other site 523796006363 active site 523796006364 zinc binding site [ion binding]; other site 523796006365 Na+ binding site [ion binding]; other site 523796006366 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 523796006367 CTP synthetase; Validated; Region: pyrG; PRK05380 523796006368 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 523796006369 Catalytic site [active] 523796006370 active site 523796006371 UTP binding site [chemical binding]; other site 523796006372 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 523796006373 active site 523796006374 putative oxyanion hole; other site 523796006375 catalytic triad [active] 523796006376 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343 523796006377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796006378 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 523796006379 Coenzyme A binding pocket [chemical binding]; other site 523796006380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796006381 Coenzyme A binding pocket [chemical binding]; other site 523796006382 pantothenate kinase; Provisional; Region: PRK13317 523796006383 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 523796006384 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523796006385 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 523796006386 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 523796006387 metal binding site [ion binding]; metal-binding site 523796006388 S-ribosylhomocysteinase; Provisional; Region: PRK02260 523796006389 Predicted membrane protein [Function unknown]; Region: COG4270 523796006390 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 523796006391 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 523796006392 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 523796006393 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 523796006394 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 523796006395 intersubunit interface [polypeptide binding]; other site 523796006396 active site 523796006397 catalytic residue [active] 523796006398 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 523796006399 Ferritin-like domain; Region: Ferritin; pfam00210 523796006400 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 523796006401 dimerization interface [polypeptide binding]; other site 523796006402 DPS ferroxidase diiron center [ion binding]; other site 523796006403 ion pore; other site 523796006404 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 523796006405 EVE domain; Region: EVE; cl00728 523796006406 EVE domain; Region: EVE; pfam01878 523796006407 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 523796006408 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 523796006409 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 523796006410 NADH(P)-binding; Region: NAD_binding_10; pfam13460 523796006411 NAD(P) binding site [chemical binding]; other site 523796006412 putative active site [active] 523796006413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523796006414 dimerization interface [polypeptide binding]; other site 523796006415 putative DNA binding site [nucleotide binding]; other site 523796006416 putative Zn2+ binding site [ion binding]; other site 523796006417 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 523796006418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 523796006419 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 523796006420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796006421 active site 523796006422 motif I; other site 523796006423 motif II; other site 523796006424 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 523796006425 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 523796006426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796006427 Walker A/P-loop; other site 523796006428 ATP binding site [chemical binding]; other site 523796006429 Q-loop/lid; other site 523796006430 ABC transporter signature motif; other site 523796006431 Walker B; other site 523796006432 D-loop; other site 523796006433 H-loop/switch region; other site 523796006434 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 523796006435 TIR domain; Region: TIR_2; pfam13676 523796006436 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 523796006437 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 523796006438 Helix-turn-helix domain; Region: HTH_38; pfam13936 523796006439 DNA-binding interface [nucleotide binding]; DNA binding site 523796006440 AAA domain; Region: AAA_22; pfam13401 523796006441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 523796006442 Transposase; Region: DDE_Tnp_ISL3; pfam01610 523796006443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 523796006444 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 523796006445 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 523796006446 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 523796006447 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 523796006448 glutaminase active site [active] 523796006449 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 523796006450 dimer interface [polypeptide binding]; other site 523796006451 active site 523796006452 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 523796006453 dimer interface [polypeptide binding]; other site 523796006454 active site 523796006455 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 523796006456 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 523796006457 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 523796006458 active site 523796006459 P-loop; other site 523796006460 phosphorylation site [posttranslational modification] 523796006461 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 523796006462 HTH domain; Region: HTH_11; cl17392 523796006463 Mga helix-turn-helix domain; Region: Mga; pfam05043 523796006464 PRD domain; Region: PRD; pfam00874 523796006465 PRD domain; Region: PRD; pfam00874 523796006466 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 523796006467 active site 523796006468 P-loop; other site 523796006469 phosphorylation site [posttranslational modification] 523796006470 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523796006471 active site 523796006472 phosphorylation site [posttranslational modification] 523796006473 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 523796006474 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 523796006475 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 523796006476 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 523796006477 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 523796006478 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006479 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006480 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006481 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006482 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006483 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006484 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006485 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006486 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006487 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006488 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006489 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006490 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006491 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006492 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 523796006493 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 523796006494 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 523796006495 active site 523796006496 substrate binding site [chemical binding]; other site 523796006497 metal binding site [ion binding]; metal-binding site 523796006498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 523796006499 YbbR-like protein; Region: YbbR; pfam07949 523796006500 YbbR-like protein; Region: YbbR; pfam07949 523796006501 TIGR00159 family protein; Region: TIGR00159 523796006502 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 523796006503 Arginase family; Region: Arginase; cd09989 523796006504 active site 523796006505 Mn binding site [ion binding]; other site 523796006506 oligomer interface [polypeptide binding]; other site 523796006507 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 523796006508 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 523796006509 Walker A motif; other site 523796006510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796006511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796006512 putative substrate translocation pore; other site 523796006513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796006514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796006515 putative substrate translocation pore; other site 523796006516 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 523796006517 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 523796006518 substrate binding site; other site 523796006519 dimerization interface; other site 523796006520 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 523796006521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 523796006522 Nucleoside recognition; Region: Gate; pfam07670 523796006523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796006524 ABC-ATPase subunit interface; other site 523796006525 dimer interface [polypeptide binding]; other site 523796006526 putative PBP binding regions; other site 523796006527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523796006528 ABC-ATPase subunit interface; other site 523796006529 dimer interface [polypeptide binding]; other site 523796006530 putative PBP binding regions; other site 523796006531 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 523796006532 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 523796006533 siderophore binding site; other site 523796006534 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 523796006535 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 523796006536 dimer interface [polypeptide binding]; other site 523796006537 active site 523796006538 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523796006539 substrate binding site [chemical binding]; other site 523796006540 catalytic residue [active] 523796006541 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 523796006542 IucA / IucC family; Region: IucA_IucC; pfam04183 523796006543 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 523796006544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796006545 putative substrate translocation pore; other site 523796006546 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 523796006547 IucA / IucC family; Region: IucA_IucC; pfam04183 523796006548 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 523796006549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 523796006550 Small integral membrane protein [Function unknown]; Region: COG5547 523796006551 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 523796006552 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 523796006553 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 523796006554 putative NAD(P) binding site [chemical binding]; other site 523796006555 dimer interface [polypeptide binding]; other site 523796006556 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 523796006557 Prostaglandin dehydrogenases; Region: PGDH; cd05288 523796006558 NAD(P) binding site [chemical binding]; other site 523796006559 substrate binding site [chemical binding]; other site 523796006560 dimer interface [polypeptide binding]; other site 523796006561 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 523796006562 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 523796006563 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 523796006564 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 523796006565 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 523796006566 active site 523796006567 P-loop; other site 523796006568 phosphorylation site [posttranslational modification] 523796006569 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 523796006570 methionine cluster; other site 523796006571 active site 523796006572 phosphorylation site [posttranslational modification] 523796006573 metal binding site [ion binding]; metal-binding site 523796006574 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 523796006575 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 523796006576 putative substrate binding site [chemical binding]; other site 523796006577 putative ATP binding site [chemical binding]; other site 523796006578 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 523796006579 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 523796006580 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 523796006581 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 523796006582 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 523796006583 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 523796006584 NAD+ binding site [chemical binding]; other site 523796006585 substrate binding site [chemical binding]; other site 523796006586 putative Zn binding site [ion binding]; other site 523796006587 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 523796006588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 523796006589 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 523796006590 active site 523796006591 catalytic tetrad [active] 523796006592 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 523796006593 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 523796006594 DNA binding residues [nucleotide binding] 523796006595 putative dimer interface [polypeptide binding]; other site 523796006596 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 523796006597 substrate binding site [chemical binding]; other site 523796006598 catalytic residues [active] 523796006599 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 523796006600 Peptidase family M23; Region: Peptidase_M23; pfam01551 523796006601 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 523796006602 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523796006603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 523796006604 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 523796006605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796006606 active site 523796006607 motif I; other site 523796006608 motif II; other site 523796006609 MAP domain; Region: MAP; pfam03642 523796006610 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 523796006611 acetolactate synthase; Reviewed; Region: PRK08617 523796006612 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 523796006613 PYR/PP interface [polypeptide binding]; other site 523796006614 dimer interface [polypeptide binding]; other site 523796006615 TPP binding site [chemical binding]; other site 523796006616 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 523796006617 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 523796006618 TPP-binding site [chemical binding]; other site 523796006619 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 523796006620 Helix-turn-helix domain; Region: HTH_38; pfam13936 523796006621 Homeodomain-like domain; Region: HTH_32; pfam13565 523796006622 Integrase core domain; Region: rve; pfam00665 523796006623 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 523796006624 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 523796006625 23S rRNA interface [nucleotide binding]; other site 523796006626 L3 interface [polypeptide binding]; other site 523796006627 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 523796006628 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 523796006629 dimerization interface 3.5A [polypeptide binding]; other site 523796006630 active site 523796006631 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 523796006632 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 523796006633 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 523796006634 Walker A/P-loop; other site 523796006635 ATP binding site [chemical binding]; other site 523796006636 Q-loop/lid; other site 523796006637 ABC transporter signature motif; other site 523796006638 Walker B; other site 523796006639 D-loop; other site 523796006640 H-loop/switch region; other site 523796006641 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 523796006642 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 523796006643 Walker A/P-loop; other site 523796006644 ATP binding site [chemical binding]; other site 523796006645 Q-loop/lid; other site 523796006646 ABC transporter signature motif; other site 523796006647 Walker B; other site 523796006648 D-loop; other site 523796006649 H-loop/switch region; other site 523796006650 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 523796006651 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 523796006652 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 523796006653 alphaNTD homodimer interface [polypeptide binding]; other site 523796006654 alphaNTD - beta interaction site [polypeptide binding]; other site 523796006655 alphaNTD - beta' interaction site [polypeptide binding]; other site 523796006656 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 523796006657 30S ribosomal protein S11; Validated; Region: PRK05309 523796006658 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 523796006659 30S ribosomal protein S13; Region: bact_S13; TIGR03631 523796006660 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 523796006661 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 523796006662 rRNA binding site [nucleotide binding]; other site 523796006663 predicted 30S ribosome binding site; other site 523796006664 adenylate kinase; Reviewed; Region: adk; PRK00279 523796006665 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 523796006666 AMP-binding site [chemical binding]; other site 523796006667 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 523796006668 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 523796006669 SecY translocase; Region: SecY; pfam00344 523796006670 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 523796006671 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 523796006672 23S rRNA binding site [nucleotide binding]; other site 523796006673 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 523796006674 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 523796006675 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 523796006676 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 523796006677 5S rRNA interface [nucleotide binding]; other site 523796006678 L27 interface [polypeptide binding]; other site 523796006679 23S rRNA interface [nucleotide binding]; other site 523796006680 L5 interface [polypeptide binding]; other site 523796006681 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 523796006682 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 523796006683 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 523796006684 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 523796006685 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 523796006686 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 523796006687 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 523796006688 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 523796006689 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 523796006690 RNA binding site [nucleotide binding]; other site 523796006691 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 523796006692 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 523796006693 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 523796006694 23S rRNA interface [nucleotide binding]; other site 523796006695 putative translocon interaction site; other site 523796006696 signal recognition particle (SRP54) interaction site; other site 523796006697 L23 interface [polypeptide binding]; other site 523796006698 trigger factor interaction site; other site 523796006699 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 523796006700 23S rRNA interface [nucleotide binding]; other site 523796006701 5S rRNA interface [nucleotide binding]; other site 523796006702 putative antibiotic binding site [chemical binding]; other site 523796006703 L25 interface [polypeptide binding]; other site 523796006704 L27 interface [polypeptide binding]; other site 523796006705 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 523796006706 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 523796006707 G-X-X-G motif; other site 523796006708 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 523796006709 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 523796006710 putative translocon binding site; other site 523796006711 protein-rRNA interface [nucleotide binding]; other site 523796006712 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 523796006713 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 523796006714 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 523796006715 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 523796006716 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 523796006717 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 523796006718 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 523796006719 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 523796006720 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 523796006721 DNA topoisomerase III; Provisional; Region: PRK07726 523796006722 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 523796006723 active site 523796006724 putative interdomain interaction site [polypeptide binding]; other site 523796006725 putative metal-binding site [ion binding]; other site 523796006726 putative nucleotide binding site [chemical binding]; other site 523796006727 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 523796006728 domain I; other site 523796006729 DNA binding groove [nucleotide binding] 523796006730 phosphate binding site [ion binding]; other site 523796006731 domain II; other site 523796006732 domain III; other site 523796006733 nucleotide binding site [chemical binding]; other site 523796006734 catalytic site [active] 523796006735 domain IV; other site 523796006736 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 523796006737 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 523796006738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796006739 Coenzyme A binding pocket [chemical binding]; other site 523796006740 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 523796006741 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 523796006742 Predicted permeases [General function prediction only]; Region: COG0679 523796006743 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 523796006744 MMPL family; Region: MMPL; cl14618 523796006745 MMPL family; Region: MMPL; cl14618 523796006746 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 523796006747 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 523796006748 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796006749 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 523796006750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796006751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796006752 putative substrate translocation pore; other site 523796006753 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 523796006754 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796006755 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 523796006756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796006757 FeS/SAM binding site; other site 523796006758 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 523796006759 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 523796006760 GTP binding site; other site 523796006761 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 523796006762 MoaE interaction surface [polypeptide binding]; other site 523796006763 MoeB interaction surface [polypeptide binding]; other site 523796006764 thiocarboxylated glycine; other site 523796006765 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 523796006766 MoaE homodimer interface [polypeptide binding]; other site 523796006767 MoaD interaction [polypeptide binding]; other site 523796006768 active site residues [active] 523796006769 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 523796006770 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 523796006771 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 523796006772 dimer interface [polypeptide binding]; other site 523796006773 putative functional site; other site 523796006774 putative MPT binding site; other site 523796006775 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 523796006776 trimer interface [polypeptide binding]; other site 523796006777 dimer interface [polypeptide binding]; other site 523796006778 putative active site [active] 523796006779 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 523796006780 MPT binding site; other site 523796006781 trimer interface [polypeptide binding]; other site 523796006782 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 523796006783 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 523796006784 ATP binding site [chemical binding]; other site 523796006785 substrate interface [chemical binding]; other site 523796006786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796006787 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 523796006788 Walker A/P-loop; other site 523796006789 ATP binding site [chemical binding]; other site 523796006790 Q-loop/lid; other site 523796006791 ABC transporter signature motif; other site 523796006792 Walker B; other site 523796006793 D-loop; other site 523796006794 H-loop/switch region; other site 523796006795 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 523796006796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796006797 dimer interface [polypeptide binding]; other site 523796006798 conserved gate region; other site 523796006799 putative PBP binding loops; other site 523796006800 ABC-ATPase subunit interface; other site 523796006801 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 523796006802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523796006803 substrate binding pocket [chemical binding]; other site 523796006804 membrane-bound complex binding site; other site 523796006805 hinge residues; other site 523796006806 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 523796006807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796006808 Coenzyme A binding pocket [chemical binding]; other site 523796006809 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 523796006810 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 523796006811 active site 523796006812 dimerization interface [polypeptide binding]; other site 523796006813 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 523796006814 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 523796006815 intersubunit interface [polypeptide binding]; other site 523796006816 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 523796006817 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 523796006818 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 523796006819 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 523796006820 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 523796006821 alpha-gamma subunit interface [polypeptide binding]; other site 523796006822 beta-gamma subunit interface [polypeptide binding]; other site 523796006823 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 523796006824 gamma-beta subunit interface [polypeptide binding]; other site 523796006825 alpha-beta subunit interface [polypeptide binding]; other site 523796006826 urease subunit alpha; Reviewed; Region: ureC; PRK13207 523796006827 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 523796006828 subunit interactions [polypeptide binding]; other site 523796006829 active site 523796006830 flap region; other site 523796006831 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 523796006832 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 523796006833 dimer interface [polypeptide binding]; other site 523796006834 catalytic residues [active] 523796006835 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 523796006836 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 523796006837 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 523796006838 MarR family; Region: MarR_2; cl17246 523796006839 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796006840 Bacterial PH domain; Region: bPH_3; pfam14470 523796006841 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 523796006842 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 523796006843 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796006844 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523796006845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523796006846 Surface antigen [General function prediction only]; Region: COG3942 523796006847 CHAP domain; Region: CHAP; pfam05257 523796006848 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 523796006849 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 523796006850 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 523796006851 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 523796006852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 523796006853 Surface antigen [General function prediction only]; Region: COG3942 523796006854 CHAP domain; Region: CHAP; pfam05257 523796006855 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 523796006856 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 523796006857 putative ligand binding site [chemical binding]; other site 523796006858 putative NAD binding site [chemical binding]; other site 523796006859 catalytic site [active] 523796006860 hypothetical protein; Provisional; Region: PRK06753 523796006861 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 523796006862 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 523796006863 Lysozyme subfamily 2; Region: LYZ2; smart00047 523796006864 Uncharacterized conserved protein [Function unknown]; Region: COG2427 523796006865 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 523796006866 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 523796006867 catalytic loop [active] 523796006868 iron binding site [ion binding]; other site 523796006869 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 523796006870 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 523796006871 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 523796006872 [4Fe-4S] binding site [ion binding]; other site 523796006873 molybdopterin cofactor binding site; other site 523796006874 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 523796006875 molybdopterin cofactor binding site; other site 523796006876 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 523796006877 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 523796006878 active site 523796006879 Predicted transcriptional regulator [Transcription]; Region: COG2378 523796006880 HTH domain; Region: HTH_11; pfam08279 523796006881 CAAX protease self-immunity; Region: Abi; pfam02517 523796006882 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 523796006883 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 523796006884 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 523796006885 putative active site [active] 523796006886 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 523796006887 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 523796006888 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 523796006889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796006890 active site 523796006891 motif I; other site 523796006892 motif II; other site 523796006893 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 523796006894 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 523796006895 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523796006896 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523796006897 active site turn [active] 523796006898 phosphorylation site [posttranslational modification] 523796006899 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 523796006900 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 523796006901 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 523796006902 putative active site [active] 523796006903 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 523796006904 putative hydrophobic ligand binding site [chemical binding]; other site 523796006905 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 523796006906 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 523796006907 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 523796006908 oxidoreductase; Provisional; Region: PRK07985 523796006909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523796006910 NAD(P) binding site [chemical binding]; other site 523796006911 active site 523796006912 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 523796006913 amidohydrolase; Region: amidohydrolases; TIGR01891 523796006914 metal binding site [ion binding]; metal-binding site 523796006915 dimer interface [polypeptide binding]; other site 523796006916 imidazolonepropionase; Validated; Region: PRK09356 523796006917 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 523796006918 active site 523796006919 urocanate hydratase; Provisional; Region: PRK05414 523796006920 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523796006921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523796006922 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 523796006923 dimerization interface [polypeptide binding]; other site 523796006924 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 523796006925 putative active site [active] 523796006926 putative metal binding site [ion binding]; other site 523796006927 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 523796006928 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 523796006929 tetramer (dimer of dimers) interface [polypeptide binding]; other site 523796006930 active site 523796006931 dimer interface [polypeptide binding]; other site 523796006932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 523796006933 MOSC domain; Region: MOSC; pfam03473 523796006934 3-alpha domain; Region: 3-alpha; pfam03475 523796006935 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 523796006936 active site 523796006937 catalytic residues [active] 523796006938 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 523796006939 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 523796006940 Acyltransferase family; Region: Acyl_transf_3; cl19154 523796006941 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 523796006942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796006943 Walker A/P-loop; other site 523796006944 ATP binding site [chemical binding]; other site 523796006945 Q-loop/lid; other site 523796006946 ABC transporter signature motif; other site 523796006947 Walker B; other site 523796006948 D-loop; other site 523796006949 H-loop/switch region; other site 523796006950 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 523796006951 Predicted membrane protein [Function unknown]; Region: COG3152 523796006952 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 523796006953 active site 523796006954 DNA binding site [nucleotide binding] 523796006955 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 523796006956 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 523796006957 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 523796006958 homotetramer interface [polypeptide binding]; other site 523796006959 FMN binding site [chemical binding]; other site 523796006960 homodimer contacts [polypeptide binding]; other site 523796006961 putative active site [active] 523796006962 putative substrate binding site [chemical binding]; other site 523796006963 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 523796006964 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 523796006965 oligomer interface [polypeptide binding]; other site 523796006966 metal binding site [ion binding]; metal-binding site 523796006967 metal binding site [ion binding]; metal-binding site 523796006968 putative Cl binding site [ion binding]; other site 523796006969 aspartate ring; other site 523796006970 basic sphincter; other site 523796006971 hydrophobic gate; other site 523796006972 periplasmic entrance; other site 523796006973 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 523796006974 active site 523796006975 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 523796006976 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 523796006977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796006978 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 523796006979 putative substrate translocation pore; other site 523796006980 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 523796006981 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 523796006982 lipoyl-biotinyl attachment site [posttranslational modification]; other site 523796006983 HlyD family secretion protein; Region: HlyD_3; pfam13437 523796006984 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 523796006985 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 523796006986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 523796006987 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 523796006988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796006989 putative substrate translocation pore; other site 523796006990 Predicted membrane protein [Function unknown]; Region: COG4640 523796006991 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 523796006992 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796006993 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523796006994 putative Zn2+ binding site [ion binding]; other site 523796006995 putative DNA binding site [nucleotide binding]; other site 523796006996 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 523796006997 putative active site [active] 523796006998 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 523796006999 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523796007000 Walker A/P-loop; other site 523796007001 ATP binding site [chemical binding]; other site 523796007002 Q-loop/lid; other site 523796007003 ABC transporter signature motif; other site 523796007004 Walker B; other site 523796007005 D-loop; other site 523796007006 H-loop/switch region; other site 523796007007 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 523796007008 FtsX-like permease family; Region: FtsX; pfam02687 523796007009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523796007010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796007011 active site 523796007012 phosphorylation site [posttranslational modification] 523796007013 intermolecular recognition site; other site 523796007014 dimerization interface [polypeptide binding]; other site 523796007015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523796007016 DNA binding site [nucleotide binding] 523796007017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523796007018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523796007019 dimerization interface [polypeptide binding]; other site 523796007020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523796007021 dimer interface [polypeptide binding]; other site 523796007022 phosphorylation site [posttranslational modification] 523796007023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796007024 ATP binding site [chemical binding]; other site 523796007025 Mg2+ binding site [ion binding]; other site 523796007026 G-X-G motif; other site 523796007027 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 523796007028 LytTr DNA-binding domain; Region: LytTR; smart00850 523796007029 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 523796007030 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 523796007031 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 523796007032 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 523796007033 L-lactate permease; Region: Lactate_perm; cl00701 523796007034 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 523796007035 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 523796007036 Helix-turn-helix domain; Region: HTH_38; pfam13936 523796007037 Homeodomain-like domain; Region: HTH_32; pfam13565 523796007038 Integrase core domain; Region: rve; pfam00665 523796007039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 523796007040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796007041 Coenzyme A binding pocket [chemical binding]; other site 523796007042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 523796007043 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 523796007044 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 523796007045 NAD(P) binding site [chemical binding]; other site 523796007046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796007047 Coenzyme A binding pocket [chemical binding]; other site 523796007048 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 523796007049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796007050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796007051 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 523796007052 Predicted membrane protein [Function unknown]; Region: COG1511 523796007053 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 523796007054 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 523796007055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523796007056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523796007057 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 523796007058 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 523796007059 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 523796007060 Cl binding site [ion binding]; other site 523796007061 oligomer interface [polypeptide binding]; other site 523796007062 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 523796007063 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523796007064 active site turn [active] 523796007065 phosphorylation site [posttranslational modification] 523796007066 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523796007067 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 523796007068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523796007069 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523796007070 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 523796007071 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 523796007072 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 523796007073 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 523796007074 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 523796007075 MarR family; Region: MarR_2; pfam12802 523796007076 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 523796007077 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 523796007078 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 523796007079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796007080 putative substrate translocation pore; other site 523796007081 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 523796007082 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 523796007083 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 523796007084 DNA binding residues [nucleotide binding] 523796007085 dimer interface [polypeptide binding]; other site 523796007086 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 523796007087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 523796007088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796007089 active site 523796007090 phosphorylation site [posttranslational modification] 523796007091 intermolecular recognition site; other site 523796007092 dimerization interface [polypeptide binding]; other site 523796007093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 523796007094 DNA binding residues [nucleotide binding] 523796007095 dimerization interface [polypeptide binding]; other site 523796007096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 523796007097 Histidine kinase; Region: HisKA_3; pfam07730 523796007098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796007099 ATP binding site [chemical binding]; other site 523796007100 Mg2+ binding site [ion binding]; other site 523796007101 G-X-G motif; other site 523796007102 GAF domain; Region: GAF_2; pfam13185 523796007103 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 523796007104 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 523796007105 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 523796007106 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 523796007107 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 523796007108 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 523796007109 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 523796007110 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 523796007111 [4Fe-4S] binding site [ion binding]; other site 523796007112 molybdopterin cofactor binding site [chemical binding]; other site 523796007113 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 523796007114 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 523796007115 molybdopterin cofactor binding site; other site 523796007116 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 523796007117 active site 523796007118 SAM binding site [chemical binding]; other site 523796007119 homodimer interface [polypeptide binding]; other site 523796007120 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 523796007121 [2Fe-2S] cluster binding site [ion binding]; other site 523796007122 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 523796007123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796007124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523796007125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796007126 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 523796007127 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 523796007128 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 523796007129 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 523796007130 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 523796007131 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 523796007132 putative active site [active] 523796007133 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 523796007134 active site 523796007135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 523796007136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796007137 Coenzyme A binding pocket [chemical binding]; other site 523796007138 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 523796007139 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 523796007140 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 523796007141 putative hydrophobic ligand binding site [chemical binding]; other site 523796007142 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 523796007143 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 523796007144 intersubunit interface [polypeptide binding]; other site 523796007145 YodA lipocalin-like domain; Region: YodA; pfam09223 523796007146 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 523796007147 Thioredoxin; Region: Thioredoxin_4; cl17273 523796007148 Domain of unknown function with cystatin-like fold (DUF4467); Region: DUF4467; pfam14729 523796007149 FemAB family; Region: FemAB; pfam02388 523796007150 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 523796007151 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 523796007152 Walker A/P-loop; other site 523796007153 ATP binding site [chemical binding]; other site 523796007154 Q-loop/lid; other site 523796007155 ABC transporter signature motif; other site 523796007156 Walker B; other site 523796007157 D-loop; other site 523796007158 H-loop/switch region; other site 523796007159 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 523796007160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796007161 dimer interface [polypeptide binding]; other site 523796007162 conserved gate region; other site 523796007163 putative PBP binding loops; other site 523796007164 ABC-ATPase subunit interface; other site 523796007165 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523796007166 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523796007167 substrate binding pocket [chemical binding]; other site 523796007168 membrane-bound complex binding site; other site 523796007169 hinge residues; other site 523796007170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796007171 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796007172 putative substrate translocation pore; other site 523796007173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796007174 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523796007175 catalytic core [active] 523796007176 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523796007177 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 523796007178 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 523796007179 B domain; Region: B; pfam02216 523796007180 B domain; Region: B; pfam02216 523796007181 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 523796007182 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 523796007183 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 523796007184 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 523796007185 beta-channel forming cytolysin; Region: hlyII; TIGR01002 523796007186 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 523796007187 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 523796007188 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 523796007189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523796007190 catalytic residue [active] 523796007191 biotin synthase; Validated; Region: PRK06256 523796007192 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796007193 FeS/SAM binding site; other site 523796007194 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 523796007195 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 523796007196 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523796007197 inhibitor-cofactor binding pocket; inhibition site 523796007198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796007199 catalytic residue [active] 523796007200 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 523796007201 AAA domain; Region: AAA_26; pfam13500 523796007202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 523796007203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523796007204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796007205 Walker A/P-loop; other site 523796007206 ATP binding site [chemical binding]; other site 523796007207 Q-loop/lid; other site 523796007208 ABC transporter signature motif; other site 523796007209 Walker B; other site 523796007210 D-loop; other site 523796007211 H-loop/switch region; other site 523796007212 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 523796007213 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523796007214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796007215 Walker A/P-loop; other site 523796007216 ATP binding site [chemical binding]; other site 523796007217 Q-loop/lid; other site 523796007218 ABC transporter signature motif; other site 523796007219 Walker B; other site 523796007220 D-loop; other site 523796007221 H-loop/switch region; other site 523796007222 GtrA-like protein; Region: GtrA; pfam04138 523796007223 glycerate kinase; Region: TIGR00045 523796007224 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 523796007225 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 523796007226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796007227 putative substrate translocation pore; other site 523796007228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 523796007229 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 523796007230 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 523796007231 putative phosphoesterase; Region: acc_ester; TIGR03729 523796007232 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 523796007233 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 523796007234 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 523796007235 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 523796007236 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 523796007237 Beta-lactamase; Region: Beta-lactamase; pfam00144 523796007238 DHHC palmitoyltransferase; Region: zf-DHHC; cl19890 523796007239 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 523796007240 extended (e) SDRs; Region: SDR_e; cd08946 523796007241 NAD(P) binding site [chemical binding]; other site 523796007242 active site 523796007243 substrate binding site [chemical binding]; other site 523796007244 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 523796007245 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 523796007246 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 523796007247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796007248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796007249 putative substrate translocation pore; other site 523796007250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796007251 dimer interface [polypeptide binding]; other site 523796007252 conserved gate region; other site 523796007253 ABC-ATPase subunit interface; other site 523796007254 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 523796007255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796007256 dimer interface [polypeptide binding]; other site 523796007257 conserved gate region; other site 523796007258 putative PBP binding loops; other site 523796007259 ABC-ATPase subunit interface; other site 523796007260 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 523796007261 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 523796007262 Walker A/P-loop; other site 523796007263 ATP binding site [chemical binding]; other site 523796007264 Q-loop/lid; other site 523796007265 ABC transporter signature motif; other site 523796007266 Walker B; other site 523796007267 D-loop; other site 523796007268 H-loop/switch region; other site 523796007269 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 523796007270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 523796007271 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 523796007272 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 523796007273 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 523796007274 amino acid transporter; Region: 2A0306; TIGR00909 523796007275 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 523796007276 substrate binding pocket [chemical binding]; other site 523796007277 catalytic triad [active] 523796007278 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 523796007279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796007280 putative substrate translocation pore; other site 523796007281 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 523796007282 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 523796007283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796007284 Walker A/P-loop; other site 523796007285 ATP binding site [chemical binding]; other site 523796007286 Q-loop/lid; other site 523796007287 ABC transporter signature motif; other site 523796007288 Walker B; other site 523796007289 D-loop; other site 523796007290 H-loop/switch region; other site 523796007291 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 523796007292 oligomer interface [polypeptide binding]; other site 523796007293 active site 523796007294 metal binding site [ion binding]; metal-binding site 523796007295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 523796007296 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 523796007297 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 523796007298 active site 523796007299 FMN binding site [chemical binding]; other site 523796007300 substrate binding site [chemical binding]; other site 523796007301 3Fe-4S cluster binding site [ion binding]; other site 523796007302 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 523796007303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796007304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796007305 putative substrate translocation pore; other site 523796007306 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 523796007307 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523796007308 Walker A/P-loop; other site 523796007309 ATP binding site [chemical binding]; other site 523796007310 Q-loop/lid; other site 523796007311 ABC transporter signature motif; other site 523796007312 Walker B; other site 523796007313 D-loop; other site 523796007314 H-loop/switch region; other site 523796007315 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523796007316 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 523796007317 Walker A/P-loop; other site 523796007318 ATP binding site [chemical binding]; other site 523796007319 Q-loop/lid; other site 523796007320 ABC transporter signature motif; other site 523796007321 Walker B; other site 523796007322 D-loop; other site 523796007323 H-loop/switch region; other site 523796007324 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523796007325 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 523796007326 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 523796007327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796007328 dimer interface [polypeptide binding]; other site 523796007329 conserved gate region; other site 523796007330 putative PBP binding loops; other site 523796007331 ABC-ATPase subunit interface; other site 523796007332 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523796007333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523796007334 dimer interface [polypeptide binding]; other site 523796007335 conserved gate region; other site 523796007336 putative PBP binding loops; other site 523796007337 ABC-ATPase subunit interface; other site 523796007338 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 523796007339 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 523796007340 substrate binding site [chemical binding]; other site 523796007341 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 523796007342 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 523796007343 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 523796007344 short chain dehydrogenase; Validated; Region: PRK08589 523796007345 classical (c) SDRs; Region: SDR_c; cd05233 523796007346 NAD(P) binding site [chemical binding]; other site 523796007347 active site 523796007348 AbgT putative transporter family; Region: ABG_transport; pfam03806 523796007349 Uncharacterized conserved protein [Function unknown]; Region: COG2128 523796007350 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 523796007351 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796007352 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796007353 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796007354 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796007355 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 523796007356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 523796007357 Helix-turn-helix domain; Region: HTH_28; pfam13518 523796007358 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 523796007359 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 523796007360 classical (c) SDRs; Region: SDR_c; cd05233 523796007361 NAD(P) binding site [chemical binding]; other site 523796007362 active site 523796007363 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 523796007364 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 523796007365 nucleophilic elbow; other site 523796007366 catalytic triad; other site 523796007367 Protein of unknown function, DUF576; Region: DUF576; pfam04507 523796007368 Protein of unknown function, DUF576; Region: DUF576; pfam04507 523796007369 Protein of unknown function, DUF576; Region: DUF576; pfam04507 523796007370 EcoRII C terminal; Region: EcoRII-C; pfam09019 523796007371 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796007372 non-specific DNA binding site [nucleotide binding]; other site 523796007373 salt bridge; other site 523796007374 sequence-specific DNA binding site [nucleotide binding]; other site 523796007375 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 523796007376 cofactor binding site; other site 523796007377 DNA binding site [nucleotide binding] 523796007378 substrate interaction site [chemical binding]; other site 523796007379 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 523796007380 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 523796007381 active site 523796007382 substrate binding site [chemical binding]; other site 523796007383 metal binding site [ion binding]; metal-binding site 523796007384 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 523796007385 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 523796007386 active site 523796007387 tetramer interface; other site 523796007388 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 523796007389 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 523796007390 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 523796007391 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 523796007392 GntP family permease; Region: GntP_permease; pfam02447 523796007393 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 523796007394 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 523796007395 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 523796007396 N- and C-terminal domain interface [polypeptide binding]; other site 523796007397 active site 523796007398 catalytic site [active] 523796007399 metal binding site [ion binding]; metal-binding site 523796007400 carbohydrate binding site [chemical binding]; other site 523796007401 ATP binding site [chemical binding]; other site 523796007402 Transcriptional regulators [Transcription]; Region: GntR; COG1802 523796007403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 523796007404 DNA-binding site [nucleotide binding]; DNA binding site 523796007405 FCD domain; Region: FCD; pfam07729 523796007406 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 523796007407 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 523796007408 DNA binding residues [nucleotide binding] 523796007409 dimer interface [polypeptide binding]; other site 523796007410 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 523796007411 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 523796007412 synthetase active site [active] 523796007413 NTP binding site [chemical binding]; other site 523796007414 metal binding site [ion binding]; metal-binding site 523796007415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 523796007416 Predicted membrane protein [Function unknown]; Region: COG1289 523796007417 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 523796007418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796007419 D-galactonate transporter; Region: 2A0114; TIGR00893 523796007420 putative substrate translocation pore; other site 523796007421 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 523796007422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796007423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796007424 putative substrate translocation pore; other site 523796007425 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796007426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 523796007427 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 523796007428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523796007429 Walker A/P-loop; other site 523796007430 ATP binding site [chemical binding]; other site 523796007431 Q-loop/lid; other site 523796007432 ABC transporter signature motif; other site 523796007433 Walker B; other site 523796007434 D-loop; other site 523796007435 H-loop/switch region; other site 523796007436 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 523796007437 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 523796007438 Uncharacterized membrane protein [Function unknown]; Region: COG3949 523796007439 Predicted esterase [General function prediction only]; Region: COG0400 523796007440 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 523796007441 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 523796007442 Zn binding site [ion binding]; other site 523796007443 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 523796007444 Zn binding site [ion binding]; other site 523796007445 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523796007446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 523796007447 putative Zn2+ binding site [ion binding]; other site 523796007448 putative DNA binding site [nucleotide binding]; other site 523796007449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796007450 Coenzyme A binding pocket [chemical binding]; other site 523796007451 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 523796007452 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 523796007453 putative metal binding site [ion binding]; other site 523796007454 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 523796007455 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 523796007456 dimer interface [polypeptide binding]; other site 523796007457 FMN binding site [chemical binding]; other site 523796007458 D-lactate dehydrogenase; Validated; Region: PRK08605 523796007459 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 523796007460 homodimer interface [polypeptide binding]; other site 523796007461 ligand binding site [chemical binding]; other site 523796007462 NAD binding site [chemical binding]; other site 523796007463 catalytic site [active] 523796007464 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 523796007465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523796007466 active site 523796007467 motif I; other site 523796007468 motif II; other site 523796007469 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 523796007470 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 523796007471 active site 523796007472 catalytic site [active] 523796007473 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 523796007474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796007475 Coenzyme A binding pocket [chemical binding]; other site 523796007476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 523796007477 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 523796007478 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 523796007479 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 523796007480 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 523796007481 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 523796007482 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 523796007483 EamA-like transporter family; Region: EamA; pfam00892 523796007484 EamA-like transporter family; Region: EamA; pfam00892 523796007485 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 523796007486 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 523796007487 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523796007488 catalytic residues [active] 523796007489 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 523796007490 active site 523796007491 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523796007492 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 523796007493 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523796007494 active site turn [active] 523796007495 phosphorylation site [posttranslational modification] 523796007496 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 523796007497 HPr interaction site; other site 523796007498 glycerol kinase (GK) interaction site [polypeptide binding]; other site 523796007499 active site 523796007500 phosphorylation site [posttranslational modification] 523796007501 pyruvate oxidase; Provisional; Region: PRK08611 523796007502 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 523796007503 PYR/PP interface [polypeptide binding]; other site 523796007504 tetramer interface [polypeptide binding]; other site 523796007505 dimer interface [polypeptide binding]; other site 523796007506 TPP binding site [chemical binding]; other site 523796007507 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 523796007508 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 523796007509 TPP-binding site [chemical binding]; other site 523796007510 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 523796007511 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 523796007512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523796007513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523796007514 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 523796007515 putative dimerization interface [polypeptide binding]; other site 523796007516 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 523796007517 Surface antigen [General function prediction only]; Region: COG3942 523796007518 CHAP domain; Region: CHAP; pfam05257 523796007519 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 523796007520 homodimer interface [polypeptide binding]; other site 523796007521 catalytic residues [active] 523796007522 NAD binding site [chemical binding]; other site 523796007523 substrate binding pocket [chemical binding]; other site 523796007524 flexible flap; other site 523796007525 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 523796007526 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 523796007527 dimer interface [polypeptide binding]; other site 523796007528 active site 523796007529 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 523796007530 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 523796007531 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 523796007532 DNA binding site [nucleotide binding] 523796007533 active site 523796007534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796007535 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 523796007536 Walker A motif; other site 523796007537 ATP binding site [chemical binding]; other site 523796007538 Walker B motif; other site 523796007539 arginine finger; other site 523796007540 UvrB/uvrC motif; Region: UVR; pfam02151 523796007541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523796007542 Walker A motif; other site 523796007543 ATP binding site [chemical binding]; other site 523796007544 Walker B motif; other site 523796007545 arginine finger; other site 523796007546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 523796007547 Virus attachment protein p12 family; Region: P12; pfam12669 523796007548 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 523796007549 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 523796007550 G1 box; other site 523796007551 GTP/Mg2+ binding site [chemical binding]; other site 523796007552 Switch I region; other site 523796007553 G2 box; other site 523796007554 G3 box; other site 523796007555 Switch II region; other site 523796007556 G4 box; other site 523796007557 G5 box; other site 523796007558 Nucleoside recognition; Region: Gate; pfam07670 523796007559 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 523796007560 Nucleoside recognition; Region: Gate; pfam07670 523796007561 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 523796007562 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 523796007563 MMPL family; Region: MMPL; pfam03176 523796007564 MMPL family; Region: MMPL; cl14618 523796007565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523796007566 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 523796007567 Glutamate binding site [chemical binding]; other site 523796007568 homodimer interface [polypeptide binding]; other site 523796007569 NAD binding site [chemical binding]; other site 523796007570 catalytic residues [active] 523796007571 maltose O-acetyltransferase; Provisional; Region: PRK10092 523796007572 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 523796007573 active site 523796007574 substrate binding site [chemical binding]; other site 523796007575 trimer interface [polypeptide binding]; other site 523796007576 CoA binding site [chemical binding]; other site 523796007577 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523796007578 metal-binding site [ion binding] 523796007579 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 523796007580 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523796007581 metal-binding site [ion binding] 523796007582 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523796007583 Soluble P-type ATPase [General function prediction only]; Region: COG4087 523796007584 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 523796007585 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523796007586 metal-binding site [ion binding] 523796007587 D-lactate dehydrogenase; Validated; Region: PRK08605 523796007588 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 523796007589 homodimer interface [polypeptide binding]; other site 523796007590 ligand binding site [chemical binding]; other site 523796007591 NAD binding site [chemical binding]; other site 523796007592 catalytic site [active] 523796007593 LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540 523796007594 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523796007595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796007596 homodimer interface [polypeptide binding]; other site 523796007597 catalytic residue [active] 523796007598 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 523796007599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 523796007600 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 523796007601 active site lid residues [active] 523796007602 substrate binding pocket [chemical binding]; other site 523796007603 catalytic residues [active] 523796007604 substrate-Mg2+ binding site; other site 523796007605 aspartate-rich region 1; other site 523796007606 aspartate-rich region 2; other site 523796007607 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 523796007608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 523796007609 active site 523796007610 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 523796007611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796007612 Surface antigen [General function prediction only]; Region: COG3942 523796007613 CHAP domain; Region: CHAP; pfam05257 523796007614 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 523796007615 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 523796007616 catalytic triad [active] 523796007617 catalytic triad [active] 523796007618 oxyanion hole [active] 523796007619 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 523796007620 catalytic residue [active] 523796007621 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 523796007622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523796007623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523796007624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 523796007625 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 523796007626 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 523796007627 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 523796007628 NADP binding site [chemical binding]; other site 523796007629 active site 523796007630 regulatory binding site [polypeptide binding]; other site 523796007631 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 523796007632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523796007633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523796007634 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 523796007635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523796007636 NAD(P) binding site [chemical binding]; other site 523796007637 active site 523796007638 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 523796007639 Putative lysophospholipase; Region: Hydrolase_4; cl19140 523796007640 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523796007641 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 523796007642 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 523796007643 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 523796007644 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 523796007645 Nucleoside recognition; Region: Gate; pfam07670 523796007646 Nucleoside recognition; Region: Gate; pfam07670 523796007647 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 523796007648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 523796007649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 523796007650 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 523796007651 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 523796007652 Phosphotransferase enzyme family; Region: APH; pfam01636 523796007653 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 523796007654 active site 523796007655 substrate binding site [chemical binding]; other site 523796007656 ATP binding site [chemical binding]; other site 523796007657 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 523796007658 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 523796007659 quinone interaction residues [chemical binding]; other site 523796007660 active site 523796007661 catalytic residues [active] 523796007662 FMN binding site [chemical binding]; other site 523796007663 substrate binding site [chemical binding]; other site 523796007664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 523796007665 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 523796007666 dimer interface [polypeptide binding]; other site 523796007667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523796007668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523796007669 Predicted acyl esterases [General function prediction only]; Region: COG2936 523796007670 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 523796007671 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 523796007672 tetramerization interface [polypeptide binding]; other site 523796007673 active site 523796007674 Pantoate-beta-alanine ligase; Region: PanC; cd00560 523796007675 active site 523796007676 ATP-binding site [chemical binding]; other site 523796007677 pantoate-binding site; other site 523796007678 HXXH motif; other site 523796007679 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 523796007680 oligomerization interface [polypeptide binding]; other site 523796007681 active site 523796007682 metal binding site [ion binding]; metal-binding site 523796007683 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 523796007684 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 523796007685 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 523796007686 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 523796007687 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 523796007688 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 523796007689 tetramer (dimer of dimers) interface [polypeptide binding]; other site 523796007690 NAD binding site [chemical binding]; other site 523796007691 dimer interface [polypeptide binding]; other site 523796007692 substrate binding site [chemical binding]; other site 523796007693 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 523796007694 amino acid transporter; Region: 2A0306; TIGR00909 523796007695 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 523796007696 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 523796007697 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523796007698 inhibitor-cofactor binding pocket; inhibition site 523796007699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796007700 catalytic residue [active] 523796007701 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 523796007702 catalytic residue [active] 523796007703 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 523796007704 Predicted dehydrogenase [General function prediction only]; Region: COG0579 523796007705 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 523796007706 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 523796007707 acyl-activating enzyme (AAE) consensus motif; other site 523796007708 AMP binding site [chemical binding]; other site 523796007709 active site 523796007710 CoA binding site [chemical binding]; other site 523796007711 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 523796007712 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 523796007713 choline dehydrogenase; Validated; Region: PRK02106 523796007714 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 523796007715 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 523796007716 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 523796007717 tetramerization interface [polypeptide binding]; other site 523796007718 NAD(P) binding site [chemical binding]; other site 523796007719 catalytic residues [active] 523796007720 Predicted transcriptional regulators [Transcription]; Region: COG1510 523796007721 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 523796007722 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 523796007723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523796007724 FeS/SAM binding site; other site 523796007725 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 523796007726 Class III ribonucleotide reductase; Region: RNR_III; cd01675 523796007727 effector binding site; other site 523796007728 active site 523796007729 Zn binding site [ion binding]; other site 523796007730 glycine loop; other site 523796007731 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 523796007732 Citrate transporter; Region: CitMHS; pfam03600 523796007733 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 523796007734 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 523796007735 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 523796007736 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 523796007737 Flavodoxin; Region: Flavodoxin_1; pfam00258 523796007738 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 523796007739 FAD binding pocket [chemical binding]; other site 523796007740 FAD binding motif [chemical binding]; other site 523796007741 catalytic residues [active] 523796007742 NAD binding pocket [chemical binding]; other site 523796007743 phosphate binding motif [ion binding]; other site 523796007744 beta-alpha-beta structure motif; other site 523796007745 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 523796007746 catalytic residues [active] 523796007747 dimer interface [polypeptide binding]; other site 523796007748 FtsX-like permease family; Region: FtsX; pfam02687 523796007749 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 523796007750 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523796007751 Walker A/P-loop; other site 523796007752 ATP binding site [chemical binding]; other site 523796007753 Q-loop/lid; other site 523796007754 ABC transporter signature motif; other site 523796007755 Walker B; other site 523796007756 D-loop; other site 523796007757 H-loop/switch region; other site 523796007758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523796007759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523796007760 ATP binding site [chemical binding]; other site 523796007761 Mg2+ binding site [ion binding]; other site 523796007762 G-X-G motif; other site 523796007763 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523796007764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523796007765 active site 523796007766 phosphorylation site [posttranslational modification] 523796007767 intermolecular recognition site; other site 523796007768 dimerization interface [polypeptide binding]; other site 523796007769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523796007770 DNA binding site [nucleotide binding] 523796007771 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 523796007772 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 523796007773 dimer interface [polypeptide binding]; other site 523796007774 active site 523796007775 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 523796007776 MarR family; Region: MarR_2; pfam12802 523796007777 Predicted esterase [General function prediction only]; Region: COG0627 523796007778 S-formylglutathione hydrolase; Region: PLN02442 523796007779 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 523796007780 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 523796007781 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 523796007782 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 523796007783 ligand binding site [chemical binding]; other site 523796007784 flexible hinge region; other site 523796007785 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 523796007786 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 523796007787 putative substrate binding site [chemical binding]; other site 523796007788 nucleotide binding site [chemical binding]; other site 523796007789 nucleotide binding site [chemical binding]; other site 523796007790 homodimer interface [polypeptide binding]; other site 523796007791 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 523796007792 ornithine carbamoyltransferase; Validated; Region: PRK02102 523796007793 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 523796007794 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 523796007795 arginine deiminase; Provisional; Region: PRK01388 523796007796 Arginine repressor [Transcription]; Region: ArgR; COG1438 523796007797 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 523796007798 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 523796007799 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 523796007800 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 523796007801 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523796007802 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 523796007803 active site 523796007804 Zn binding site [ion binding]; other site 523796007805 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 523796007806 HTH domain; Region: HTH_11; pfam08279 523796007807 PRD domain; Region: PRD; pfam00874 523796007808 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 523796007809 active site 523796007810 P-loop; other site 523796007811 phosphorylation site [posttranslational modification] 523796007812 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523796007813 active site 523796007814 phosphorylation site [posttranslational modification] 523796007815 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 523796007816 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 523796007817 active site 523796007818 P-loop; other site 523796007819 phosphorylation site [posttranslational modification] 523796007820 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 523796007821 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523796007822 active site 523796007823 phosphorylation site [posttranslational modification] 523796007824 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 523796007825 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 523796007826 Predicted membrane protein [Function unknown]; Region: COG1511 523796007827 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 523796007828 Retro-transposon transporting motif; Region: Nup_retrotrp_bd; pfam10599 523796007829 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 523796007830 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 523796007831 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 523796007832 CHAP domain; Region: CHAP; pfam05257 523796007833 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 523796007834 catalytic triad [active] 523796007835 conserved cis-peptide bond; other site 523796007836 Protein of unknown function (DUF445); Region: DUF445; pfam04286 523796007837 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 523796007838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523796007839 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 523796007840 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 523796007841 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 523796007842 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 523796007843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523796007844 ATP binding site [chemical binding]; other site 523796007845 putative Mg++ binding site [ion binding]; other site 523796007846 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 523796007847 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523796007848 nucleotide binding region [chemical binding]; other site 523796007849 ATP-binding site [chemical binding]; other site 523796007850 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 523796007851 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 523796007852 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 523796007853 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 523796007854 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 523796007855 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 523796007856 SecY translocase; Region: SecY; pfam00344 523796007857 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 523796007858 legume lectins; Region: lectin_L-type; cd01951 523796007859 homotetramer interaction site [polypeptide binding]; other site 523796007860 homodimer interaction site [polypeptide binding]; other site 523796007861 carbohydrate binding site [chemical binding]; other site 523796007862 metal binding site [ion binding]; metal-binding site 523796007863 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 523796007864 Putative Ig domain; Region: He_PIG; pfam05345 523796007865 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 523796007866 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 523796007867 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 523796007868 methionine sulfoxide reductase A; Provisional; Region: PRK05528 523796007869 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 523796007870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523796007871 Coenzyme A binding pocket [chemical binding]; other site 523796007872 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 523796007873 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 523796007874 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 523796007875 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 523796007876 Chain length determinant protein; Region: Wzz; cl15801 523796007877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523796007878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523796007879 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 523796007880 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 523796007881 DXD motif; other site 523796007882 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 523796007883 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 523796007884 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 523796007885 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 523796007886 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 523796007887 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 523796007888 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 523796007889 metal binding site [ion binding]; metal-binding site 523796007890 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 523796007891 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 523796007892 substrate binding site [chemical binding]; other site 523796007893 glutamase interaction surface [polypeptide binding]; other site 523796007894 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 523796007895 catalytic residues [active] 523796007896 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 523796007897 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 523796007898 putative active site [active] 523796007899 oxyanion strand; other site 523796007900 catalytic triad [active] 523796007901 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 523796007902 putative active site pocket [active] 523796007903 4-fold oligomerization interface [polypeptide binding]; other site 523796007904 metal binding residues [ion binding]; metal-binding site 523796007905 3-fold/trimer interface [polypeptide binding]; other site 523796007906 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 523796007907 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523796007908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523796007909 homodimer interface [polypeptide binding]; other site 523796007910 catalytic residue [active] 523796007911 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 523796007912 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 523796007913 NAD binding site [chemical binding]; other site 523796007914 dimerization interface [polypeptide binding]; other site 523796007915 product binding site; other site 523796007916 substrate binding site [chemical binding]; other site 523796007917 zinc binding site [ion binding]; other site 523796007918 catalytic residues [active] 523796007919 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 523796007920 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 523796007921 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 523796007922 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 523796007923 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 523796007924 Uncharacterized conserved protein [Function unknown]; Region: COG2353 523796007925 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 523796007926 Strictosidine synthase; Region: Str_synth; cl19733 523796007927 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 523796007928 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 523796007929 active site residue [active] 523796007930 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 523796007931 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 523796007932 putative substrate binding pocket [chemical binding]; other site 523796007933 AC domain interface; other site 523796007934 catalytic triad [active] 523796007935 AB domain interface; other site 523796007936 interchain disulfide; other site 523796007937 hypothetical protein; Validated; Region: PRK07668 523796007938 Predicted transcriptional regulators [Transcription]; Region: COG1695 523796007939 DinB superfamily; Region: DinB_2; pfam12867 523796007940 Collagen binding domain; Region: Collagen_bind; pfam05737 523796007941 Cna protein B-type domain; Region: Cna_B; pfam05738 523796007942 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 523796007943 domain interaction interfaces [polypeptide binding]; other site 523796007944 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 523796007945 domain interaction interfaces [polypeptide binding]; other site 523796007946 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 523796007947 domain interaction interfaces [polypeptide binding]; other site 523796007948 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 523796007949 domain interaction interfaces [polypeptide binding]; other site 523796007950 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 523796007951 domain interaction interfaces [polypeptide binding]; other site 523796007952 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 523796007953 domain interaction interfaces [polypeptide binding]; other site 523796007954 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 523796007955 domain interaction interfaces [polypeptide binding]; other site 523796007956 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 523796007957 anion transporter; Region: dass; TIGR00785 523796007958 transmembrane helices; other site 523796007959 Predicted permeases [General function prediction only]; Region: RarD; COG2962 523796007960 hypothetical protein; Provisional; Region: PRK07758 523796007961 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 523796007962 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 523796007963 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 523796007964 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 523796007965 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523796007966 Walker A/P-loop; other site 523796007967 ATP binding site [chemical binding]; other site 523796007968 Q-loop/lid; other site 523796007969 ABC transporter signature motif; other site 523796007970 Walker B; other site 523796007971 D-loop; other site 523796007972 H-loop/switch region; other site 523796007973 FtsX-like permease family; Region: FtsX; pfam02687 523796007974 FtsX-like permease family; Region: FtsX; pfam02687 523796007975 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 523796007976 DNA-binding site [nucleotide binding]; DNA binding site 523796007977 RNA-binding motif; other site 523796007978 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523796007979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523796007980 non-specific DNA binding site [nucleotide binding]; other site 523796007981 salt bridge; other site 523796007982 sequence-specific DNA binding site [nucleotide binding]; other site 523796007983 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 523796007984 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 523796007985 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 523796007986 ParB-like nuclease domain; Region: ParBc; pfam02195 523796007987 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523796007988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523796007989 S-adenosylmethionine binding site [chemical binding]; other site 523796007990 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 523796007991 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 523796007992 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 523796007993 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 523796007994 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 523796007995 trmE is a tRNA modification GTPase; Region: trmE; cd04164 523796007996 G1 box; other site 523796007997 GTP/Mg2+ binding site [chemical binding]; other site 523796007998 Switch I region; other site 523796007999 G2 box; other site 523796008000 Switch II region; other site 523796008001 G3 box; other site 523796008002 G4 box; other site 523796008003 G5 box; other site 523796008004 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 523796008005 ribonuclease P; Reviewed; Region: rnpA; PRK00499 523796008006 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 523796008007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 523796008008 Integrase core domain; Region: rve; pfam00665 523796008009 Replication initiation factor; Region: Rep_trans; pfam02486 523796008010 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 523796008011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523796008012 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523796008013 putative substrate translocation pore; other site 523796008014 Replication initiation factor; Region: Rep_trans; pfam02486 523796008015 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 523796008016 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 523796008017 Domain of unknown function (DUF334); Region: DUF334; pfam03904 523796008018 Replication protein; Region: Rep_1; pfam01446 523796008019 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523796008020 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445