-- dump date 20140620_075151 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1006543000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1006543000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1006543000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543000004 Walker A motif; other site 1006543000005 ATP binding site [chemical binding]; other site 1006543000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1006543000007 Walker B motif; other site 1006543000008 arginine finger; other site 1006543000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1006543000010 DnaA box-binding interface [nucleotide binding]; other site 1006543000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1006543000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1006543000013 putative DNA binding surface [nucleotide binding]; other site 1006543000014 dimer interface [polypeptide binding]; other site 1006543000015 beta-clamp/clamp loader binding surface; other site 1006543000016 beta-clamp/translesion DNA polymerase binding surface; other site 1006543000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1006543000018 recF protein; Region: recf; TIGR00611 1006543000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1006543000020 Walker A/P-loop; other site 1006543000021 ATP binding site [chemical binding]; other site 1006543000022 Q-loop/lid; other site 1006543000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543000024 ABC transporter signature motif; other site 1006543000025 Walker B; other site 1006543000026 D-loop; other site 1006543000027 H-loop/switch region; other site 1006543000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1006543000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543000030 Mg2+ binding site [ion binding]; other site 1006543000031 G-X-G motif; other site 1006543000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1006543000033 anchoring element; other site 1006543000034 dimer interface [polypeptide binding]; other site 1006543000035 ATP binding site [chemical binding]; other site 1006543000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1006543000037 active site 1006543000038 putative metal-binding site [ion binding]; other site 1006543000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1006543000040 DNA gyrase subunit A; Validated; Region: PRK05560 1006543000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1006543000042 CAP-like domain; other site 1006543000043 active site 1006543000044 primary dimer interface [polypeptide binding]; other site 1006543000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1006543000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1006543000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1006543000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1006543000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1006543000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1006543000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1006543000052 putative substrate binding site [chemical binding]; other site 1006543000053 putative ATP binding site [chemical binding]; other site 1006543000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1006543000055 active sites [active] 1006543000056 tetramer interface [polypeptide binding]; other site 1006543000057 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1006543000058 seryl-tRNA synthetase; Provisional; Region: PRK05431 1006543000059 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1006543000060 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1006543000061 dimer interface [polypeptide binding]; other site 1006543000062 active site 1006543000063 motif 1; other site 1006543000064 motif 2; other site 1006543000065 motif 3; other site 1006543000066 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1006543000067 Predicted membrane protein [Function unknown]; Region: COG4392 1006543000068 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1006543000069 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1006543000070 Predicted membrane protein [Function unknown]; Region: COG4241 1006543000071 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1006543000072 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1006543000073 DHH family; Region: DHH; pfam01368 1006543000074 DHHA1 domain; Region: DHHA1; pfam02272 1006543000075 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1006543000076 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1006543000077 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1006543000078 replicative DNA helicase; Region: DnaB; TIGR00665 1006543000079 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1006543000080 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1006543000081 Walker A motif; other site 1006543000082 ATP binding site [chemical binding]; other site 1006543000083 Walker B motif; other site 1006543000084 DNA binding loops [nucleotide binding] 1006543000085 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1006543000086 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1006543000087 GDP-binding site [chemical binding]; other site 1006543000088 ACT binding site; other site 1006543000089 IMP binding site; other site 1006543000090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1006543000091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543000092 active site 1006543000093 phosphorylation site [posttranslational modification] 1006543000094 intermolecular recognition site; other site 1006543000095 dimerization interface [polypeptide binding]; other site 1006543000096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1006543000097 DNA binding site [nucleotide binding] 1006543000098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1006543000099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1006543000100 dimerization interface [polypeptide binding]; other site 1006543000101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1006543000102 putative active site [active] 1006543000103 heme pocket [chemical binding]; other site 1006543000104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1006543000105 dimer interface [polypeptide binding]; other site 1006543000106 phosphorylation site [posttranslational modification] 1006543000107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543000108 ATP binding site [chemical binding]; other site 1006543000109 Mg2+ binding site [ion binding]; other site 1006543000110 G-X-G motif; other site 1006543000111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1006543000112 YycH protein; Region: YycH; pfam07435 1006543000113 YycH protein; Region: YycI; cl02015 1006543000114 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1006543000115 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1006543000116 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1006543000117 putative active site [active] 1006543000118 putative metal binding site [ion binding]; other site 1006543000119 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1006543000120 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1006543000121 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1006543000122 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1006543000123 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1006543000124 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 1006543000125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1006543000126 Integrase core domain; Region: rve; pfam00665 1006543000127 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1006543000128 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1006543000129 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1006543000130 putative active site [active] 1006543000131 catalytic site [active] 1006543000132 putative metal binding site [ion binding]; other site 1006543000133 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1006543000134 putative active site [active] 1006543000135 putative catalytic site [active] 1006543000136 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1006543000137 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1006543000138 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1006543000139 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1006543000140 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1006543000141 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1006543000142 Predicted transcriptional regulator [Transcription]; Region: COG3682 1006543000143 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1006543000144 MarR family; Region: MarR_2; pfam12802 1006543000145 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1006543000146 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1006543000147 nucleotide binding site [chemical binding]; other site 1006543000148 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1006543000149 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1006543000150 active site residue [active] 1006543000151 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1006543000152 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1006543000153 active site residue [active] 1006543000154 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 1006543000155 CPxP motif; other site 1006543000156 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1006543000157 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1006543000158 putative homodimer interface [polypeptide binding]; other site 1006543000159 putative homotetramer interface [polypeptide binding]; other site 1006543000160 putative metal binding site [ion binding]; other site 1006543000161 putative homodimer-homodimer interface [polypeptide binding]; other site 1006543000162 putative allosteric switch controlling residues; other site 1006543000163 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 1006543000164 Cadmium resistance transporter; Region: Cad; pfam03596 1006543000165 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1006543000166 metal-binding site [ion binding] 1006543000167 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1006543000168 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1006543000169 metal-binding site [ion binding] 1006543000170 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1006543000171 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1006543000172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1006543000173 dimerization interface [polypeptide binding]; other site 1006543000174 putative DNA binding site [nucleotide binding]; other site 1006543000175 putative Zn2+ binding site [ion binding]; other site 1006543000176 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1006543000177 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1006543000178 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1006543000179 active site 1006543000180 DNA binding site [nucleotide binding] 1006543000181 Int/Topo IB signature motif; other site 1006543000182 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1006543000183 MPN+ (JAMM) motif; other site 1006543000184 Zinc-binding site [ion binding]; other site 1006543000185 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1006543000186 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1006543000187 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1006543000188 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1006543000189 catalytic residues [active] 1006543000190 catalytic nucleophile [active] 1006543000191 Presynaptic Site I dimer interface [polypeptide binding]; other site 1006543000192 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1006543000193 Synaptic Flat tetramer interface [polypeptide binding]; other site 1006543000194 Synaptic Site I dimer interface [polypeptide binding]; other site 1006543000195 DNA binding site [nucleotide binding] 1006543000196 Recombinase; Region: Recombinase; pfam07508 1006543000197 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1006543000198 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1006543000199 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1006543000200 catalytic residues [active] 1006543000201 catalytic nucleophile [active] 1006543000202 Recombinase; Region: Recombinase; pfam07508 1006543000203 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1006543000204 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1006543000205 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1006543000206 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1006543000207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543000208 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1006543000209 Walker A motif; other site 1006543000210 ATP binding site [chemical binding]; other site 1006543000211 Walker B motif; other site 1006543000212 arginine finger; other site 1006543000213 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 1006543000214 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543000215 MULE transposase domain; Region: MULE; pfam10551 1006543000216 transposase; Provisional; Region: PRK06526 1006543000217 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1006543000218 active site 1006543000219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543000220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543000221 putative substrate translocation pore; other site 1006543000222 potential frameshift: common BLAST hit: gi|379022384|ref|YP_005299046.1| N-hydroxyarylamine O-acetyltransferase 1006543000223 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1006543000224 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1006543000225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1006543000226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1006543000227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543000228 Coenzyme A binding pocket [chemical binding]; other site 1006543000229 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1006543000230 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1006543000231 FMN binding site [chemical binding]; other site 1006543000232 active site 1006543000233 catalytic residues [active] 1006543000234 substrate binding site [chemical binding]; other site 1006543000235 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1006543000236 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543000237 MULE transposase domain; Region: MULE; pfam10551 1006543000238 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1006543000239 Part of AAA domain; Region: AAA_19; pfam13245 1006543000240 AAA domain; Region: AAA_12; pfam13087 1006543000241 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1006543000242 active site 1006543000243 catalytic site [active] 1006543000244 putative metal binding site [ion binding]; other site 1006543000245 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543000246 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1006543000247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1006543000248 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1006543000249 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1006543000250 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1006543000251 metal binding site [ion binding]; metal-binding site 1006543000252 dimer interface [polypeptide binding]; other site 1006543000253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543000254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543000255 putative substrate translocation pore; other site 1006543000256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543000257 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1006543000258 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1006543000259 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1006543000260 PhoU domain; Region: PhoU; pfam01895 1006543000261 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1006543000262 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1006543000263 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1006543000264 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1006543000265 L-lactate permease; Region: Lactate_perm; cl00701 1006543000266 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543000267 B domain; Region: B; pfam02216 1006543000268 B domain; Region: B; pfam02216 1006543000269 B domain; Region: B; pfam02216 1006543000270 B domain; Region: B; pfam02216 1006543000271 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1006543000272 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543000273 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1006543000274 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543000275 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1006543000276 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1006543000277 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543000278 ABC-ATPase subunit interface; other site 1006543000279 dimer interface [polypeptide binding]; other site 1006543000280 putative PBP binding regions; other site 1006543000281 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1006543000282 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543000283 ABC-ATPase subunit interface; other site 1006543000284 dimer interface [polypeptide binding]; other site 1006543000285 putative PBP binding regions; other site 1006543000286 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1006543000287 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1006543000288 siderophore binding site; other site 1006543000289 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1006543000290 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1006543000291 dimer interface [polypeptide binding]; other site 1006543000292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543000293 catalytic residue [active] 1006543000294 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1006543000295 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1006543000296 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1006543000297 IucA / IucC family; Region: IucA_IucC; pfam04183 1006543000298 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1006543000299 drug efflux system protein MdtG; Provisional; Region: PRK09874 1006543000300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543000301 putative substrate translocation pore; other site 1006543000302 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1006543000303 IucA / IucC family; Region: IucA_IucC; pfam04183 1006543000304 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1006543000305 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1006543000306 IucA / IucC family; Region: IucA_IucC; pfam04183 1006543000307 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1006543000308 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1006543000309 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1006543000310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1006543000311 dimer interface [polypeptide binding]; other site 1006543000312 active site 1006543000313 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1006543000314 catalytic residues [active] 1006543000315 substrate binding site [chemical binding]; other site 1006543000316 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1006543000317 ParB-like nuclease domain; Region: ParBc; pfam02195 1006543000318 acetoin reductase; Validated; Region: PRK08643 1006543000319 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1006543000320 NAD binding site [chemical binding]; other site 1006543000321 homotetramer interface [polypeptide binding]; other site 1006543000322 homodimer interface [polypeptide binding]; other site 1006543000323 active site 1006543000324 substrate binding site [chemical binding]; other site 1006543000325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1006543000326 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1006543000327 NAD(P) binding site [chemical binding]; other site 1006543000328 active site 1006543000329 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1006543000330 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1006543000331 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1006543000332 putative ADP-binding pocket [chemical binding]; other site 1006543000333 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1006543000334 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1006543000335 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1006543000336 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1006543000337 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1006543000338 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1006543000339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1006543000340 DNA-binding site [nucleotide binding]; DNA binding site 1006543000341 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1006543000342 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1006543000343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543000344 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1006543000345 intersubunit interface [polypeptide binding]; other site 1006543000346 active site 1006543000347 catalytic residue [active] 1006543000348 phosphopentomutase; Provisional; Region: PRK05362 1006543000349 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1006543000350 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1006543000351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543000352 dimer interface [polypeptide binding]; other site 1006543000353 conserved gate region; other site 1006543000354 putative PBP binding loops; other site 1006543000355 ABC-ATPase subunit interface; other site 1006543000356 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1006543000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543000358 dimer interface [polypeptide binding]; other site 1006543000359 conserved gate region; other site 1006543000360 ABC-ATPase subunit interface; other site 1006543000361 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1006543000362 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1006543000363 Walker A/P-loop; other site 1006543000364 ATP binding site [chemical binding]; other site 1006543000365 Q-loop/lid; other site 1006543000366 ABC transporter signature motif; other site 1006543000367 Walker B; other site 1006543000368 D-loop; other site 1006543000369 H-loop/switch region; other site 1006543000370 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1006543000371 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1006543000372 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1006543000373 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1006543000374 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1006543000375 active site 1006543000376 metal binding site [ion binding]; metal-binding site 1006543000377 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1006543000378 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1006543000379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543000380 non-specific DNA binding site [nucleotide binding]; other site 1006543000381 salt bridge; other site 1006543000382 sequence-specific DNA binding site [nucleotide binding]; other site 1006543000383 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1006543000384 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1006543000385 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1006543000386 putative catalytic cysteine [active] 1006543000387 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1006543000388 putative active site [active] 1006543000389 metal binding site [ion binding]; metal-binding site 1006543000390 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1006543000391 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1006543000392 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1006543000393 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1006543000394 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1006543000395 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1006543000396 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1006543000397 NAD(P) binding site [chemical binding]; other site 1006543000398 homodimer interface [polypeptide binding]; other site 1006543000399 substrate binding site [chemical binding]; other site 1006543000400 active site 1006543000401 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1006543000402 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1006543000403 NAD(P) binding site [chemical binding]; other site 1006543000404 homodimer interface [polypeptide binding]; other site 1006543000405 substrate binding site [chemical binding]; other site 1006543000406 active site 1006543000407 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1006543000408 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1006543000409 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1006543000410 putative NAD(P) binding site [chemical binding]; other site 1006543000411 active site 1006543000412 putative substrate binding site [chemical binding]; other site 1006543000413 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1006543000414 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1006543000415 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1006543000416 active site 1006543000417 homodimer interface [polypeptide binding]; other site 1006543000418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1006543000419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1006543000420 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1006543000421 trimer interface [polypeptide binding]; other site 1006543000422 active site 1006543000423 substrate binding site [chemical binding]; other site 1006543000424 CoA binding site [chemical binding]; other site 1006543000425 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1006543000426 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1006543000427 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1006543000428 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1006543000429 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1006543000430 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1006543000431 putative NAD(P) binding site [chemical binding]; other site 1006543000432 active site 1006543000433 putative substrate binding site [chemical binding]; other site 1006543000434 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1006543000435 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1006543000436 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1006543000437 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1006543000438 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1006543000439 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1006543000440 active site 1006543000441 homodimer interface [polypeptide binding]; other site 1006543000442 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1006543000443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1006543000444 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1006543000445 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1006543000446 NAD(P) binding site [chemical binding]; other site 1006543000447 catalytic residues [active] 1006543000448 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1006543000449 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1006543000450 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1006543000451 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1006543000452 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1006543000453 Walker A/P-loop; other site 1006543000454 ATP binding site [chemical binding]; other site 1006543000455 Q-loop/lid; other site 1006543000456 ABC transporter signature motif; other site 1006543000457 Walker B; other site 1006543000458 D-loop; other site 1006543000459 H-loop/switch region; other site 1006543000460 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1006543000461 NMT1-like family; Region: NMT1_2; pfam13379 1006543000462 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1006543000463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1006543000464 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1006543000465 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1006543000466 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1006543000467 formate dehydrogenase; Provisional; Region: PRK07574 1006543000468 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1006543000469 dimerization interface [polypeptide binding]; other site 1006543000470 ligand binding site [chemical binding]; other site 1006543000471 NAD binding site [chemical binding]; other site 1006543000472 catalytic site [active] 1006543000473 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1006543000474 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1006543000475 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1006543000476 acyl-activating enzyme (AAE) consensus motif; other site 1006543000477 AMP binding site [chemical binding]; other site 1006543000478 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1006543000479 Condensation domain; Region: Condensation; pfam00668 1006543000480 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1006543000481 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1006543000482 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1006543000483 acyl-activating enzyme (AAE) consensus motif; other site 1006543000484 AMP binding site [chemical binding]; other site 1006543000485 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1006543000486 thioester reductase domain; Region: Thioester-redct; TIGR01746 1006543000487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1006543000488 NAD(P) binding site [chemical binding]; other site 1006543000489 active site 1006543000490 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1006543000491 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1006543000492 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1006543000493 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1006543000494 nucleotide binding site [chemical binding]; other site 1006543000495 N-acetyl-L-glutamate binding site [chemical binding]; other site 1006543000496 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1006543000497 heterotetramer interface [polypeptide binding]; other site 1006543000498 active site pocket [active] 1006543000499 cleavage site 1006543000500 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1006543000501 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1006543000502 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1006543000503 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1006543000504 inhibitor-cofactor binding pocket; inhibition site 1006543000505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543000506 catalytic residue [active] 1006543000507 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1006543000508 Isochorismatase family; Region: Isochorismatase; pfam00857 1006543000509 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1006543000510 catalytic triad [active] 1006543000511 conserved cis-peptide bond; other site 1006543000512 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1006543000513 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1006543000514 dimer interface [polypeptide binding]; other site 1006543000515 PYR/PP interface [polypeptide binding]; other site 1006543000516 TPP binding site [chemical binding]; other site 1006543000517 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1006543000518 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1006543000519 TPP-binding site [chemical binding]; other site 1006543000520 dimer interface [polypeptide binding]; other site 1006543000521 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1006543000522 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1006543000523 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1006543000524 active site turn [active] 1006543000525 phosphorylation site [posttranslational modification] 1006543000526 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1006543000527 HPr interaction site; other site 1006543000528 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1006543000529 active site 1006543000530 phosphorylation site [posttranslational modification] 1006543000531 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1006543000532 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1006543000533 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 1006543000534 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1006543000535 putative active site [active] 1006543000536 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1006543000537 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1006543000538 active site turn [active] 1006543000539 phosphorylation site [posttranslational modification] 1006543000540 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1006543000541 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1006543000542 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1006543000543 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1006543000544 putative active site [active] 1006543000545 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1006543000546 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1006543000547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1006543000548 ATP binding site [chemical binding]; other site 1006543000549 putative Mg++ binding site [ion binding]; other site 1006543000550 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1006543000551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543000552 Walker A/P-loop; other site 1006543000553 ATP binding site [chemical binding]; other site 1006543000554 Q-loop/lid; other site 1006543000555 ABC transporter signature motif; other site 1006543000556 Walker B; other site 1006543000557 D-loop; other site 1006543000558 H-loop/switch region; other site 1006543000559 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1006543000560 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543000561 Walker A/P-loop; other site 1006543000562 ATP binding site [chemical binding]; other site 1006543000563 Q-loop/lid; other site 1006543000564 ABC transporter signature motif; other site 1006543000565 Walker B; other site 1006543000566 D-loop; other site 1006543000567 H-loop/switch region; other site 1006543000568 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1006543000569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543000570 dimer interface [polypeptide binding]; other site 1006543000571 conserved gate region; other site 1006543000572 putative PBP binding loops; other site 1006543000573 ABC-ATPase subunit interface; other site 1006543000574 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1006543000575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543000576 dimer interface [polypeptide binding]; other site 1006543000577 conserved gate region; other site 1006543000578 ABC-ATPase subunit interface; other site 1006543000579 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1006543000580 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1006543000581 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1006543000582 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1006543000583 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1006543000584 azoreductase; Reviewed; Region: PRK00170 1006543000585 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1006543000586 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1006543000587 Peptidase family M23; Region: Peptidase_M23; pfam01551 1006543000588 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1006543000589 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1006543000590 Walker A/P-loop; other site 1006543000591 ATP binding site [chemical binding]; other site 1006543000592 Q-loop/lid; other site 1006543000593 ABC transporter signature motif; other site 1006543000594 Walker B; other site 1006543000595 D-loop; other site 1006543000596 H-loop/switch region; other site 1006543000597 TOBE domain; Region: TOBE; pfam03459 1006543000598 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1006543000599 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1006543000600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543000601 dimer interface [polypeptide binding]; other site 1006543000602 conserved gate region; other site 1006543000603 ABC-ATPase subunit interface; other site 1006543000604 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1006543000605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543000606 dimer interface [polypeptide binding]; other site 1006543000607 conserved gate region; other site 1006543000608 putative PBP binding loops; other site 1006543000609 ABC-ATPase subunit interface; other site 1006543000610 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1006543000611 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1006543000612 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1006543000613 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1006543000614 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1006543000615 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1006543000616 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1006543000617 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1006543000618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1006543000619 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1006543000620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543000621 putative substrate translocation pore; other site 1006543000622 Response regulator receiver domain; Region: Response_reg; pfam00072 1006543000623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543000624 active site 1006543000625 phosphorylation site [posttranslational modification] 1006543000626 intermolecular recognition site; other site 1006543000627 dimerization interface [polypeptide binding]; other site 1006543000628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1006543000629 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1006543000630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1006543000631 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1006543000632 Histidine kinase; Region: His_kinase; pfam06580 1006543000633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543000634 ATP binding site [chemical binding]; other site 1006543000635 Mg2+ binding site [ion binding]; other site 1006543000636 G-X-G motif; other site 1006543000637 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1006543000638 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1006543000639 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1006543000640 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1006543000641 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1006543000642 Pyruvate formate lyase 1; Region: PFL1; cd01678 1006543000643 coenzyme A binding site [chemical binding]; other site 1006543000644 active site 1006543000645 catalytic residues [active] 1006543000646 glycine loop; other site 1006543000647 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1006543000648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543000649 FeS/SAM binding site; other site 1006543000650 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1006543000651 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1006543000652 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1006543000653 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1006543000654 putative active site [active] 1006543000655 catalytic site [active] 1006543000656 putative metal binding site [ion binding]; other site 1006543000657 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1006543000658 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1006543000659 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1006543000660 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1006543000661 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1006543000662 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1006543000663 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1006543000664 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1006543000665 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1006543000666 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1006543000667 dimer interface [polypeptide binding]; other site 1006543000668 active site 1006543000669 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1006543000670 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1006543000671 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1006543000672 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1006543000673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1006543000674 substrate binding site [chemical binding]; other site 1006543000675 oxyanion hole (OAH) forming residues; other site 1006543000676 trimer interface [polypeptide binding]; other site 1006543000677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1006543000678 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1006543000679 active site 1006543000680 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1006543000681 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1006543000682 acyl-activating enzyme (AAE) consensus motif; other site 1006543000683 AMP binding site [chemical binding]; other site 1006543000684 active site 1006543000685 CoA binding site [chemical binding]; other site 1006543000686 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1006543000687 Coenzyme A transferase; Region: CoA_trans; smart00882 1006543000688 Coenzyme A transferase; Region: CoA_trans; cl17247 1006543000689 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1006543000690 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1006543000691 catalytic triad [active] 1006543000692 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1006543000693 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1006543000694 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1006543000695 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1006543000696 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1006543000697 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1006543000698 heme-binding site [chemical binding]; other site 1006543000699 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1006543000700 FAD binding pocket [chemical binding]; other site 1006543000701 FAD binding motif [chemical binding]; other site 1006543000702 phosphate binding motif [ion binding]; other site 1006543000703 beta-alpha-beta structure motif; other site 1006543000704 NAD binding pocket [chemical binding]; other site 1006543000705 Heme binding pocket [chemical binding]; other site 1006543000706 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1006543000707 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1006543000708 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1006543000709 NAD binding site [chemical binding]; other site 1006543000710 dimer interface [polypeptide binding]; other site 1006543000711 substrate binding site [chemical binding]; other site 1006543000712 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1006543000713 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1006543000714 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1006543000715 active site turn [active] 1006543000716 phosphorylation site [posttranslational modification] 1006543000717 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1006543000718 active site 1006543000719 tetramer interface [polypeptide binding]; other site 1006543000720 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1006543000721 Mga helix-turn-helix domain; Region: Mga; pfam05043 1006543000722 PRD domain; Region: PRD; pfam00874 1006543000723 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1006543000724 active site 1006543000725 P-loop; other site 1006543000726 phosphorylation site [posttranslational modification] 1006543000727 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1006543000728 active site 1006543000729 phosphorylation site [posttranslational modification] 1006543000730 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1006543000731 active site 1006543000732 phosphorylation site [posttranslational modification] 1006543000733 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1006543000734 active site 1006543000735 P-loop; other site 1006543000736 phosphorylation site [posttranslational modification] 1006543000737 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1006543000738 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1006543000739 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1006543000740 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1006543000741 putative NAD(P) binding site [chemical binding]; other site 1006543000742 catalytic Zn binding site [ion binding]; other site 1006543000743 structural Zn binding site [ion binding]; other site 1006543000744 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1006543000745 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1006543000746 putative NAD(P) binding site [chemical binding]; other site 1006543000747 catalytic Zn binding site [ion binding]; other site 1006543000748 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1006543000749 substrate binding site; other site 1006543000750 dimer interface; other site 1006543000751 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1006543000752 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1006543000753 putative NAD(P) binding site [chemical binding]; other site 1006543000754 putative catalytic Zn binding site [ion binding]; other site 1006543000755 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1006543000756 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1006543000757 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1006543000758 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1006543000759 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1006543000760 substrate binding site; other site 1006543000761 dimer interface; other site 1006543000762 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1006543000763 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1006543000764 putative NAD(P) binding site [chemical binding]; other site 1006543000765 putative catalytic Zn binding site [ion binding]; other site 1006543000766 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1006543000767 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1006543000768 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1006543000769 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1006543000770 active site 1006543000771 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1006543000772 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1006543000773 Hemerythrin-like domain; Region: Hr-like; cd12108 1006543000774 Fe binding site [ion binding]; other site 1006543000775 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1006543000776 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1006543000777 Histidine kinase; Region: His_kinase; pfam06580 1006543000778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543000779 Mg2+ binding site [ion binding]; other site 1006543000780 G-X-G motif; other site 1006543000781 two-component response regulator; Provisional; Region: PRK14084 1006543000782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543000783 active site 1006543000784 phosphorylation site [posttranslational modification] 1006543000785 intermolecular recognition site; other site 1006543000786 dimerization interface [polypeptide binding]; other site 1006543000787 LytTr DNA-binding domain; Region: LytTR; pfam04397 1006543000788 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1006543000789 antiholin-like protein LrgB; Provisional; Region: PRK04288 1006543000790 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1006543000791 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1006543000792 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1006543000793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1006543000794 DNA-binding site [nucleotide binding]; DNA binding site 1006543000795 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1006543000796 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1006543000797 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1006543000798 HPr interaction site; other site 1006543000799 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1006543000800 active site 1006543000801 phosphorylation site [posttranslational modification] 1006543000802 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1006543000803 beta-galactosidase; Region: BGL; TIGR03356 1006543000804 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1006543000805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543000806 S-adenosylmethionine binding site [chemical binding]; other site 1006543000807 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1006543000808 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1006543000809 substrate binding site [chemical binding]; other site 1006543000810 dimer interface [polypeptide binding]; other site 1006543000811 ATP binding site [chemical binding]; other site 1006543000812 D-ribose pyranase; Provisional; Region: PRK11797 1006543000813 Sugar transport protein; Region: Sugar_transport; pfam06800 1006543000814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1006543000815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1006543000816 DNA binding site [nucleotide binding] 1006543000817 domain linker motif; other site 1006543000818 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1006543000819 dimerization interface [polypeptide binding]; other site 1006543000820 ligand binding site [chemical binding]; other site 1006543000821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543000822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543000823 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1006543000824 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1006543000825 active site 1006543000826 Surface antigen [General function prediction only]; Region: COG3942 1006543000827 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1006543000828 Peptidase family M23; Region: Peptidase_M23; pfam01551 1006543000829 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1006543000830 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1006543000831 Walker A/P-loop; other site 1006543000832 ATP binding site [chemical binding]; other site 1006543000833 Q-loop/lid; other site 1006543000834 ABC transporter signature motif; other site 1006543000835 Walker B; other site 1006543000836 D-loop; other site 1006543000837 H-loop/switch region; other site 1006543000838 Surface antigen [General function prediction only]; Region: COG3942 1006543000839 CHAP domain; Region: CHAP; pfam05257 1006543000840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1006543000841 Predicted membrane protein [Function unknown]; Region: COG1511 1006543000842 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1006543000843 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1006543000844 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1006543000845 Uncharacterized small protein [Function unknown]; Region: COG5417 1006543000846 Predicted membrane protein [Function unknown]; Region: COG4499 1006543000847 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1006543000848 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1006543000849 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1006543000850 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1006543000851 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1006543000852 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 1006543000853 LXG domain of WXG superfamily; Region: LXG; pfam04740 1006543000854 Protein of unknown function, DUF600; Region: DUF600; cl04640 1006543000855 Protein of unknown function, DUF600; Region: DUF600; cl04640 1006543000856 Protein of unknown function, DUF600; Region: DUF600; cl04640 1006543000857 Protein of unknown function, DUF600; Region: DUF600; cl04640 1006543000858 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1006543000859 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1006543000860 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 1006543000861 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1006543000862 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1006543000863 FtsX-like permease family; Region: FtsX; pfam02687 1006543000864 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1006543000865 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1006543000866 Walker A/P-loop; other site 1006543000867 ATP binding site [chemical binding]; other site 1006543000868 Q-loop/lid; other site 1006543000869 ABC transporter signature motif; other site 1006543000870 Walker B; other site 1006543000871 D-loop; other site 1006543000872 H-loop/switch region; other site 1006543000873 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1006543000874 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1006543000875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543000876 non-specific DNA binding site [nucleotide binding]; other site 1006543000877 salt bridge; other site 1006543000878 sequence-specific DNA binding site [nucleotide binding]; other site 1006543000879 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1006543000880 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1006543000881 substrate binding site [chemical binding]; other site 1006543000882 ATP binding site [chemical binding]; other site 1006543000883 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1006543000884 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1006543000885 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1006543000886 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1006543000887 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1006543000888 putative transporter; Provisional; Region: PRK10484 1006543000889 Na binding site [ion binding]; other site 1006543000890 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1006543000891 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1006543000892 inhibitor site; inhibition site 1006543000893 active site 1006543000894 dimer interface [polypeptide binding]; other site 1006543000895 catalytic residue [active] 1006543000896 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1006543000897 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1006543000898 nucleotide binding site [chemical binding]; other site 1006543000899 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1006543000900 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1006543000901 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1006543000902 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1006543000903 putative active site [active] 1006543000904 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1006543000905 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1006543000906 putative active site cavity [active] 1006543000907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1006543000908 Nucleoside recognition; Region: Gate; pfam07670 1006543000909 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1006543000910 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1006543000911 PGAP1-like protein; Region: PGAP1; pfam07819 1006543000912 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1006543000913 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1006543000914 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1006543000915 putative active site [active] 1006543000916 putative FMN binding site [chemical binding]; other site 1006543000917 putative substrate binding site [chemical binding]; other site 1006543000918 putative catalytic residue [active] 1006543000919 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1006543000920 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1006543000921 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1006543000922 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1006543000923 lipoyl attachment site [posttranslational modification]; other site 1006543000924 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1006543000925 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1006543000926 putative ADP-ribose binding site [chemical binding]; other site 1006543000927 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1006543000928 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1006543000929 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1006543000930 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1006543000931 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1006543000932 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1006543000933 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1006543000934 NADP binding site [chemical binding]; other site 1006543000935 putative substrate binding site [chemical binding]; other site 1006543000936 active site 1006543000937 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1006543000938 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1006543000939 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1006543000940 active site 1006543000941 phosphorylation site [posttranslational modification] 1006543000942 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1006543000943 HTH domain; Region: HTH_11; pfam08279 1006543000944 HTH domain; Region: HTH_11; pfam08279 1006543000945 PRD domain; Region: PRD; pfam00874 1006543000946 PRD domain; Region: PRD; pfam00874 1006543000947 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1006543000948 active site 1006543000949 P-loop; other site 1006543000950 phosphorylation site [posttranslational modification] 1006543000951 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1006543000952 active site 1006543000953 phosphorylation site [posttranslational modification] 1006543000954 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1006543000955 MarR family; Region: MarR_2; pfam12802 1006543000956 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1006543000957 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1006543000958 MepB protein; Region: MepB; cl01985 1006543000959 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1006543000960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543000961 putative substrate translocation pore; other site 1006543000962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543000963 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1006543000964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1006543000965 Zn binding site [ion binding]; other site 1006543000966 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1006543000967 Zn binding site [ion binding]; other site 1006543000968 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1006543000969 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1006543000970 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1006543000971 Predicted flavoprotein [General function prediction only]; Region: COG0431 1006543000972 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1006543000973 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1006543000974 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1006543000975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1006543000976 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1006543000977 Imelysin; Region: Peptidase_M75; pfam09375 1006543000978 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1006543000979 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1006543000980 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1006543000981 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1006543000982 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1006543000983 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1006543000984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543000985 non-specific DNA binding site [nucleotide binding]; other site 1006543000986 salt bridge; other site 1006543000987 sequence-specific DNA binding site [nucleotide binding]; other site 1006543000988 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1006543000989 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1006543000990 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1006543000991 Walker A/P-loop; other site 1006543000992 ATP binding site [chemical binding]; other site 1006543000993 Q-loop/lid; other site 1006543000994 ABC transporter signature motif; other site 1006543000995 Walker B; other site 1006543000996 D-loop; other site 1006543000997 H-loop/switch region; other site 1006543000998 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1006543000999 Predicted membrane protein [Function unknown]; Region: COG4292 1006543001000 putative acyltransferase; Provisional; Region: PRK05790 1006543001001 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1006543001002 dimer interface [polypeptide binding]; other site 1006543001003 active site 1006543001004 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1006543001005 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1006543001006 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1006543001007 THF binding site; other site 1006543001008 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1006543001009 substrate binding site [chemical binding]; other site 1006543001010 THF binding site; other site 1006543001011 zinc-binding site [ion binding]; other site 1006543001012 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1006543001013 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1006543001014 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1006543001015 FAD binding site [chemical binding]; other site 1006543001016 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1006543001017 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1006543001018 homodimer interface [polypeptide binding]; other site 1006543001019 substrate-cofactor binding pocket; other site 1006543001020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543001021 catalytic residue [active] 1006543001022 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1006543001023 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1006543001024 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1006543001025 catalytic residue [active] 1006543001026 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1006543001027 ParB-like nuclease domain; Region: ParB; smart00470 1006543001028 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1006543001029 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1006543001030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 1006543001031 GTP-binding protein YchF; Reviewed; Region: PRK09601 1006543001032 YchF GTPase; Region: YchF; cd01900 1006543001033 G1 box; other site 1006543001034 GTP/Mg2+ binding site [chemical binding]; other site 1006543001035 Switch I region; other site 1006543001036 G2 box; other site 1006543001037 Switch II region; other site 1006543001038 G3 box; other site 1006543001039 G4 box; other site 1006543001040 G5 box; other site 1006543001041 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1006543001042 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1006543001043 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1006543001044 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1006543001045 dimer interface [polypeptide binding]; other site 1006543001046 ssDNA binding site [nucleotide binding]; other site 1006543001047 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1006543001048 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1006543001049 KilA-N domain; Region: KilA-N; pfam04383 1006543001050 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1006543001051 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1006543001052 Int/Topo IB signature motif; other site 1006543001053 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1006543001054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543001055 non-specific DNA binding site [nucleotide binding]; other site 1006543001056 salt bridge; other site 1006543001057 sequence-specific DNA binding site [nucleotide binding]; other site 1006543001058 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1006543001059 sequence-specific DNA binding site [nucleotide binding]; other site 1006543001060 salt bridge; other site 1006543001061 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1006543001062 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 1006543001063 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1006543001064 polymerase nucleotide-binding site; other site 1006543001065 DNA-binding residues [nucleotide binding]; DNA binding site 1006543001066 nucleotide binding site [chemical binding]; other site 1006543001067 primase nucleotide-binding site [nucleotide binding]; other site 1006543001068 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1006543001069 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1006543001070 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1006543001071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543001072 Coenzyme A binding pocket [chemical binding]; other site 1006543001073 Abi-like protein; Region: Abi_2; pfam07751 1006543001074 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1006543001075 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1006543001076 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1006543001078 Predicted membrane protein [Function unknown]; Region: COG3212 1006543001079 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1006543001080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1006543001081 non-specific DNA binding site [nucleotide binding]; other site 1006543001082 salt bridge; other site 1006543001083 sequence-specific DNA binding site [nucleotide binding]; other site 1006543001084 Predicted membrane protein [Function unknown]; Region: COG2261 1006543001085 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1006543001086 catalytic core [active] 1006543001087 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1006543001088 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1006543001089 catalytic residue [active] 1006543001090 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1006543001091 catalytic residues [active] 1006543001092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1006543001093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543001094 peroxiredoxin; Region: AhpC; TIGR03137 1006543001095 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1006543001096 dimer interface [polypeptide binding]; other site 1006543001097 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1006543001098 catalytic triad [active] 1006543001099 peroxidatic and resolving cysteines [active] 1006543001100 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1006543001101 dimer interface [polypeptide binding]; other site 1006543001102 FMN binding site [chemical binding]; other site 1006543001103 NADPH bind site [chemical binding]; other site 1006543001104 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1006543001105 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1006543001106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1006543001107 active site 1006543001108 xanthine permease; Region: pbuX; TIGR03173 1006543001109 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1006543001110 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1006543001111 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1006543001112 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1006543001113 active site 1006543001114 GMP synthase; Reviewed; Region: guaA; PRK00074 1006543001115 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1006543001116 AMP/PPi binding site [chemical binding]; other site 1006543001117 candidate oxyanion hole; other site 1006543001118 catalytic triad [active] 1006543001119 potential glutamine specificity residues [chemical binding]; other site 1006543001120 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1006543001121 ATP Binding subdomain [chemical binding]; other site 1006543001122 Ligand Binding sites [chemical binding]; other site 1006543001123 Dimerization subdomain; other site 1006543001124 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1006543001125 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1006543001126 Int/Topo IB signature motif; other site 1006543001127 Helix-turn-helix domain; Region: HTH_16; pfam12645 1006543001128 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1006543001129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1006543001130 DNA binding residues [nucleotide binding] 1006543001131 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1006543001132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543001133 non-specific DNA binding site [nucleotide binding]; other site 1006543001134 salt bridge; other site 1006543001135 sequence-specific DNA binding site [nucleotide binding]; other site 1006543001136 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1006543001137 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1006543001138 G1 box; other site 1006543001139 putative GEF interaction site [polypeptide binding]; other site 1006543001140 GTP/Mg2+ binding site [chemical binding]; other site 1006543001141 Switch I region; other site 1006543001142 G2 box; other site 1006543001143 G3 box; other site 1006543001144 Switch II region; other site 1006543001145 G4 box; other site 1006543001146 G5 box; other site 1006543001147 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1006543001148 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1006543001149 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1006543001150 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1006543001151 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1006543001152 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1006543001153 catalytic residue [active] 1006543001154 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1006543001155 NlpC/P60 family; Region: NLPC_P60; pfam00877 1006543001156 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1006543001157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543001158 AAA-like domain; Region: AAA_10; pfam12846 1006543001159 TcpE family; Region: TcpE; pfam12648 1006543001160 transposase/IS protein; Provisional; Region: PRK09183 1006543001161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543001162 Walker A motif; other site 1006543001163 ATP binding site [chemical binding]; other site 1006543001164 Walker B motif; other site 1006543001165 arginine finger; other site 1006543001166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1006543001167 Integrase core domain; Region: rve; pfam00665 1006543001168 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1006543001169 Abortive infection C-terminus; Region: Abi_C; pfam14355 1006543001170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543001171 non-specific DNA binding site [nucleotide binding]; other site 1006543001172 salt bridge; other site 1006543001173 sequence-specific DNA binding site [nucleotide binding]; other site 1006543001174 Replication initiation factor; Region: Rep_trans; pfam02486 1006543001175 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1006543001176 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1006543001177 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1006543001178 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1006543001179 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1006543001180 Part of AAA domain; Region: AAA_19; pfam13245 1006543001181 Family description; Region: UvrD_C_2; pfam13538 1006543001182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543001183 AAA domain; Region: AAA_21; pfam13304 1006543001184 Walker A/P-loop; other site 1006543001185 ATP binding site [chemical binding]; other site 1006543001186 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1006543001187 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1006543001188 putative active site [active] 1006543001189 putative metal-binding site [ion binding]; other site 1006543001190 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543001191 MULE transposase domain; Region: MULE; pfam10551 1006543001192 PemK-like protein; Region: PemK; pfam02452 1006543001193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1006543001194 Transposase; Region: HTH_Tnp_1; cl17663 1006543001195 Predicted membrane protein [Function unknown]; Region: COG3759 1006543001196 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1006543001197 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1006543001198 NADP binding site [chemical binding]; other site 1006543001199 superantigen-like protein; Reviewed; Region: PRK13037 1006543001200 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001201 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001202 superantigen-like protein; Reviewed; Region: PRK13041 1006543001203 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001204 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001205 superantigen-like protein; Reviewed; Region: PRK13335 1006543001206 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001207 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001208 superantigen-like protein; Reviewed; Region: PRK13042 1006543001209 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001210 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001211 superantigen-like protein 5; Reviewed; Region: PRK13035 1006543001212 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001213 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001214 superantigen-like protein; Reviewed; Region: PRK13040 1006543001215 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001216 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001217 superantigen-like protein 7; Reviewed; Region: PRK13346 1006543001218 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001219 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001220 superantigen-like protein; Reviewed; Region: PRK13039 1006543001221 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001222 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001223 superantigen-like protein; Reviewed; Region: PRK13345 1006543001224 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001225 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001226 superantigen-like protein 5; Reviewed; Region: PRK13035 1006543001227 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001228 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001229 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1006543001230 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1006543001231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543001232 S-adenosylmethionine binding site [chemical binding]; other site 1006543001233 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1006543001234 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1006543001235 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1006543001236 superantigen-like protein; Reviewed; Region: PRK13036 1006543001237 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1006543001238 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543001239 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 1006543001240 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543001241 Protein of unknown function, DUF576; Region: DUF576; cl04553 1006543001242 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543001243 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543001244 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543001245 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543001246 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543001247 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543001248 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543001249 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1006543001250 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1006543001251 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1006543001252 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1006543001253 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1006543001254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1006543001255 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1006543001256 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1006543001257 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1006543001258 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1006543001259 active site 1006543001260 Esterase/lipase [General function prediction only]; Region: COG1647 1006543001261 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1006543001262 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1006543001263 Na2 binding site [ion binding]; other site 1006543001264 putative substrate binding site 1 [chemical binding]; other site 1006543001265 Na binding site 1 [ion binding]; other site 1006543001266 putative substrate binding site 2 [chemical binding]; other site 1006543001267 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1006543001268 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1006543001269 dimer interface [polypeptide binding]; other site 1006543001270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543001271 catalytic residue [active] 1006543001272 cystathionine beta-lyase; Provisional; Region: PRK07671 1006543001273 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1006543001274 homodimer interface [polypeptide binding]; other site 1006543001275 substrate-cofactor binding pocket; other site 1006543001276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543001277 catalytic residue [active] 1006543001278 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1006543001279 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1006543001280 Walker A/P-loop; other site 1006543001281 ATP binding site [chemical binding]; other site 1006543001282 Q-loop/lid; other site 1006543001283 ABC transporter signature motif; other site 1006543001284 Walker B; other site 1006543001285 D-loop; other site 1006543001286 H-loop/switch region; other site 1006543001287 NIL domain; Region: NIL; pfam09383 1006543001288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543001289 dimer interface [polypeptide binding]; other site 1006543001290 conserved gate region; other site 1006543001291 ABC-ATPase subunit interface; other site 1006543001292 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1006543001293 LysM domain; Region: LysM; pfam01476 1006543001294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1006543001295 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1006543001296 Surface antigen [General function prediction only]; Region: COG3942 1006543001297 CHAP domain; Region: CHAP; pfam05257 1006543001298 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1006543001299 nudix motif; other site 1006543001300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543001301 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1006543001302 Coenzyme A binding pocket [chemical binding]; other site 1006543001303 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1006543001304 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1006543001305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1006543001306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1006543001307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1006543001308 dimerization interface [polypeptide binding]; other site 1006543001309 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1006543001310 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1006543001311 active site 1006543001312 dimer interface [polypeptide binding]; other site 1006543001313 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1006543001314 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1006543001315 active site 1006543001316 FMN binding site [chemical binding]; other site 1006543001317 substrate binding site [chemical binding]; other site 1006543001318 3Fe-4S cluster binding site [ion binding]; other site 1006543001319 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1006543001320 domain interface; other site 1006543001321 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1006543001322 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1006543001323 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1006543001324 active site turn [active] 1006543001325 phosphorylation site [posttranslational modification] 1006543001326 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1006543001327 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1006543001328 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1006543001329 Ca binding site [ion binding]; other site 1006543001330 active site 1006543001331 catalytic site [active] 1006543001332 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1006543001333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1006543001334 DNA-binding site [nucleotide binding]; DNA binding site 1006543001335 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1006543001336 UTRA domain; Region: UTRA; pfam07702 1006543001337 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1006543001338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543001339 Coenzyme A binding pocket [chemical binding]; other site 1006543001340 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1006543001341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543001342 Walker A motif; other site 1006543001343 ATP binding site [chemical binding]; other site 1006543001344 Walker B motif; other site 1006543001345 arginine finger; other site 1006543001346 hypothetical protein; Validated; Region: PRK00153 1006543001347 recombination protein RecR; Reviewed; Region: recR; PRK00076 1006543001348 RecR protein; Region: RecR; pfam02132 1006543001349 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1006543001350 putative active site [active] 1006543001351 putative metal-binding site [ion binding]; other site 1006543001352 tetramer interface [polypeptide binding]; other site 1006543001353 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1006543001354 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1006543001355 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1006543001356 catalytic residue [active] 1006543001357 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1006543001358 thymidylate kinase; Validated; Region: tmk; PRK00698 1006543001359 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1006543001360 TMP-binding site; other site 1006543001361 ATP-binding site [chemical binding]; other site 1006543001362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1006543001363 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1006543001364 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1006543001365 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1006543001366 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1006543001367 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1006543001368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543001369 S-adenosylmethionine binding site [chemical binding]; other site 1006543001370 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1006543001371 GIY-YIG motif/motif A; other site 1006543001372 putative active site [active] 1006543001373 putative metal binding site [ion binding]; other site 1006543001374 Predicted methyltransferases [General function prediction only]; Region: COG0313 1006543001375 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1006543001376 putative SAM binding site [chemical binding]; other site 1006543001377 putative homodimer interface [polypeptide binding]; other site 1006543001378 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1006543001379 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1006543001380 active site 1006543001381 HIGH motif; other site 1006543001382 KMSKS motif; other site 1006543001383 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1006543001384 tRNA binding surface [nucleotide binding]; other site 1006543001385 anticodon binding site; other site 1006543001386 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1006543001387 dimer interface [polypeptide binding]; other site 1006543001388 putative tRNA-binding site [nucleotide binding]; other site 1006543001389 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1006543001390 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1006543001391 active site 1006543001392 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1006543001393 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1006543001394 putative active site [active] 1006543001395 putative metal binding site [ion binding]; other site 1006543001396 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1006543001397 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1006543001398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543001399 S-adenosylmethionine binding site [chemical binding]; other site 1006543001400 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1006543001401 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1006543001402 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1006543001403 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1006543001404 pur operon repressor; Provisional; Region: PRK09213 1006543001405 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1006543001406 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1006543001407 active site 1006543001408 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1006543001409 homotrimer interaction site [polypeptide binding]; other site 1006543001410 putative active site [active] 1006543001411 regulatory protein SpoVG; Reviewed; Region: PRK13259 1006543001412 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1006543001413 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1006543001414 Substrate binding site; other site 1006543001415 Mg++ binding site; other site 1006543001416 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1006543001417 active site 1006543001418 substrate binding site [chemical binding]; other site 1006543001419 CoA binding site [chemical binding]; other site 1006543001420 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1006543001421 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1006543001422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1006543001423 active site 1006543001424 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1006543001425 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1006543001426 5S rRNA interface [nucleotide binding]; other site 1006543001427 CTC domain interface [polypeptide binding]; other site 1006543001428 L16 interface [polypeptide binding]; other site 1006543001429 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1006543001430 putative active site [active] 1006543001431 catalytic residue [active] 1006543001432 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1006543001433 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1006543001434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1006543001435 ATP binding site [chemical binding]; other site 1006543001436 putative Mg++ binding site [ion binding]; other site 1006543001437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1006543001438 nucleotide binding region [chemical binding]; other site 1006543001439 ATP-binding site [chemical binding]; other site 1006543001440 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1006543001441 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1006543001442 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1006543001443 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1006543001444 putative SAM binding site [chemical binding]; other site 1006543001445 putative homodimer interface [polypeptide binding]; other site 1006543001446 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1006543001447 homodimer interface [polypeptide binding]; other site 1006543001448 metal binding site [ion binding]; metal-binding site 1006543001449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1006543001450 RNA binding surface [nucleotide binding]; other site 1006543001451 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1006543001452 Septum formation initiator; Region: DivIC; pfam04977 1006543001453 hypothetical protein; Provisional; Region: PRK08582 1006543001454 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1006543001455 RNA binding site [nucleotide binding]; other site 1006543001456 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1006543001457 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1006543001458 Ligand Binding Site [chemical binding]; other site 1006543001459 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1006543001460 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1006543001461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1006543001462 active site 1006543001463 FtsH Extracellular; Region: FtsH_ext; pfam06480 1006543001464 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1006543001465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543001466 Walker A motif; other site 1006543001467 ATP binding site [chemical binding]; other site 1006543001468 Walker B motif; other site 1006543001469 arginine finger; other site 1006543001470 Peptidase family M41; Region: Peptidase_M41; pfam01434 1006543001471 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1006543001472 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1006543001473 dimerization interface [polypeptide binding]; other site 1006543001474 domain crossover interface; other site 1006543001475 redox-dependent activation switch; other site 1006543001476 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1006543001477 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1006543001478 dimer interface [polypeptide binding]; other site 1006543001479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543001480 catalytic residue [active] 1006543001481 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1006543001482 dihydropteroate synthase; Region: DHPS; TIGR01496 1006543001483 substrate binding pocket [chemical binding]; other site 1006543001484 dimer interface [polypeptide binding]; other site 1006543001485 inhibitor binding site; inhibition site 1006543001486 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1006543001487 homooctamer interface [polypeptide binding]; other site 1006543001488 active site 1006543001489 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1006543001490 catalytic center binding site [active] 1006543001491 ATP binding site [chemical binding]; other site 1006543001492 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1006543001493 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1006543001494 dimer interface [polypeptide binding]; other site 1006543001495 putative anticodon binding site; other site 1006543001496 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1006543001497 motif 1; other site 1006543001498 active site 1006543001499 motif 2; other site 1006543001500 motif 3; other site 1006543001501 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1006543001502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1006543001503 DNA-binding site [nucleotide binding]; DNA binding site 1006543001504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1006543001505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543001506 homodimer interface [polypeptide binding]; other site 1006543001507 catalytic residue [active] 1006543001508 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1006543001509 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1006543001510 active site 1006543001511 multimer interface [polypeptide binding]; other site 1006543001512 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1006543001513 predicted active site [active] 1006543001514 catalytic triad [active] 1006543001515 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1006543001516 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1006543001517 Nucleoside recognition; Region: Gate; pfam07670 1006543001518 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1006543001519 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1006543001520 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1006543001521 UvrB/uvrC motif; Region: UVR; pfam02151 1006543001522 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1006543001523 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1006543001524 ADP binding site [chemical binding]; other site 1006543001525 phosphagen binding site; other site 1006543001526 substrate specificity loop; other site 1006543001527 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1006543001528 Clp amino terminal domain; Region: Clp_N; pfam02861 1006543001529 Clp amino terminal domain; Region: Clp_N; pfam02861 1006543001530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543001531 Walker A motif; other site 1006543001532 ATP binding site [chemical binding]; other site 1006543001533 Walker B motif; other site 1006543001534 arginine finger; other site 1006543001535 UvrB/uvrC motif; Region: UVR; pfam02151 1006543001536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543001537 Walker A motif; other site 1006543001538 ATP binding site [chemical binding]; other site 1006543001539 Walker B motif; other site 1006543001540 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1006543001541 DNA repair protein RadA; Provisional; Region: PRK11823 1006543001542 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1006543001543 Walker A motif/ATP binding site; other site 1006543001544 ATP binding site [chemical binding]; other site 1006543001545 Walker B motif; other site 1006543001546 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1006543001547 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1006543001548 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1006543001549 putative active site [active] 1006543001550 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1006543001551 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1006543001552 active site 1006543001553 HIGH motif; other site 1006543001554 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1006543001555 active site 1006543001556 KMSKS motif; other site 1006543001557 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1006543001558 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1006543001559 trimer interface [polypeptide binding]; other site 1006543001560 active site 1006543001561 substrate binding site [chemical binding]; other site 1006543001562 CoA binding site [chemical binding]; other site 1006543001563 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1006543001564 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1006543001565 active site 1006543001566 HIGH motif; other site 1006543001567 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1006543001568 KMSKS motif; other site 1006543001569 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1006543001570 tRNA binding surface [nucleotide binding]; other site 1006543001571 anticodon binding site; other site 1006543001572 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1006543001573 active site 1006543001574 dimerization interface [polypeptide binding]; other site 1006543001575 metal binding site [ion binding]; metal-binding site 1006543001576 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1006543001577 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1006543001578 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1006543001579 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1006543001580 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1006543001581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1006543001582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1006543001583 DNA binding residues [nucleotide binding] 1006543001584 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1006543001585 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1006543001586 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1006543001587 putative homodimer interface [polypeptide binding]; other site 1006543001588 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1006543001589 heterodimer interface [polypeptide binding]; other site 1006543001590 homodimer interface [polypeptide binding]; other site 1006543001591 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1006543001592 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1006543001593 23S rRNA interface [nucleotide binding]; other site 1006543001594 L7/L12 interface [polypeptide binding]; other site 1006543001595 putative thiostrepton binding site; other site 1006543001596 L25 interface [polypeptide binding]; other site 1006543001597 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1006543001598 mRNA/rRNA interface [nucleotide binding]; other site 1006543001599 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1006543001600 23S rRNA interface [nucleotide binding]; other site 1006543001601 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1006543001602 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1006543001603 peripheral dimer interface [polypeptide binding]; other site 1006543001604 core dimer interface [polypeptide binding]; other site 1006543001605 L10 interface [polypeptide binding]; other site 1006543001606 L11 interface [polypeptide binding]; other site 1006543001607 putative EF-Tu interaction site [polypeptide binding]; other site 1006543001608 putative EF-G interaction site [polypeptide binding]; other site 1006543001609 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1006543001610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543001611 S-adenosylmethionine binding site [chemical binding]; other site 1006543001612 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1006543001613 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1006543001614 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1006543001615 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1006543001616 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1006543001617 RPB10 interaction site [polypeptide binding]; other site 1006543001618 RPB1 interaction site [polypeptide binding]; other site 1006543001619 RPB11 interaction site [polypeptide binding]; other site 1006543001620 RPB3 interaction site [polypeptide binding]; other site 1006543001621 RPB12 interaction site [polypeptide binding]; other site 1006543001622 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1006543001623 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1006543001624 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1006543001625 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1006543001626 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1006543001627 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1006543001628 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1006543001629 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1006543001630 G-loop; other site 1006543001631 DNA binding site [nucleotide binding] 1006543001632 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1006543001633 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1006543001634 S17 interaction site [polypeptide binding]; other site 1006543001635 S8 interaction site; other site 1006543001636 16S rRNA interaction site [nucleotide binding]; other site 1006543001637 streptomycin interaction site [chemical binding]; other site 1006543001638 23S rRNA interaction site [nucleotide binding]; other site 1006543001639 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1006543001640 30S ribosomal protein S7; Validated; Region: PRK05302 1006543001641 elongation factor G; Reviewed; Region: PRK00007 1006543001642 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1006543001643 G1 box; other site 1006543001644 putative GEF interaction site [polypeptide binding]; other site 1006543001645 GTP/Mg2+ binding site [chemical binding]; other site 1006543001646 Switch I region; other site 1006543001647 G2 box; other site 1006543001648 G3 box; other site 1006543001649 Switch II region; other site 1006543001650 G4 box; other site 1006543001651 G5 box; other site 1006543001652 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1006543001653 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1006543001654 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1006543001655 elongation factor Tu; Reviewed; Region: PRK00049 1006543001656 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1006543001657 G1 box; other site 1006543001658 GEF interaction site [polypeptide binding]; other site 1006543001659 GTP/Mg2+ binding site [chemical binding]; other site 1006543001660 Switch I region; other site 1006543001661 G2 box; other site 1006543001662 G3 box; other site 1006543001663 Switch II region; other site 1006543001664 G4 box; other site 1006543001665 G5 box; other site 1006543001666 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1006543001667 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1006543001668 Antibiotic Binding Site [chemical binding]; other site 1006543001669 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1006543001670 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1006543001671 metal binding site [ion binding]; metal-binding site 1006543001672 dimer interface [polypeptide binding]; other site 1006543001673 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1006543001674 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1006543001675 substrate-cofactor binding pocket; other site 1006543001676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543001677 catalytic residue [active] 1006543001678 chaperone protein HchA; Provisional; Region: PRK04155 1006543001679 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1006543001680 dimer interface [polypeptide binding]; other site 1006543001681 metal binding site [ion binding]; metal-binding site 1006543001682 potential oxyanion hole; other site 1006543001683 potential catalytic triad [active] 1006543001684 conserved cys residue [active] 1006543001685 ribulokinase; Provisional; Region: PRK04123 1006543001686 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1006543001687 N- and C-terminal domain interface [polypeptide binding]; other site 1006543001688 active site 1006543001689 MgATP binding site [chemical binding]; other site 1006543001690 catalytic site [active] 1006543001691 metal binding site [ion binding]; metal-binding site 1006543001692 carbohydrate binding site [chemical binding]; other site 1006543001693 homodimer interface [polypeptide binding]; other site 1006543001694 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1006543001695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1006543001696 NAD(P) binding site [chemical binding]; other site 1006543001697 active site 1006543001698 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1006543001699 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1006543001700 homodimer interface [polypeptide binding]; other site 1006543001701 substrate-cofactor binding pocket; other site 1006543001702 catalytic residue [active] 1006543001703 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1006543001704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543001705 motif II; other site 1006543001706 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1006543001707 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1006543001708 Substrate-binding site [chemical binding]; other site 1006543001709 Substrate specificity [chemical binding]; other site 1006543001710 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1006543001711 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1006543001712 Substrate-binding site [chemical binding]; other site 1006543001713 Substrate specificity [chemical binding]; other site 1006543001714 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1006543001715 nucleoside/Zn binding site; other site 1006543001716 dimer interface [polypeptide binding]; other site 1006543001717 catalytic motif [active] 1006543001718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543001719 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1006543001720 active site 1006543001721 motif I; other site 1006543001722 motif II; other site 1006543001723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543001724 Predicted flavoprotein [General function prediction only]; Region: COG0431 1006543001725 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1006543001726 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543001727 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1006543001728 Cna protein B-type domain; Region: Cna_B; pfam05738 1006543001729 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1006543001730 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543001731 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1006543001732 Cna protein B-type domain; Region: Cna_B; pfam05738 1006543001733 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1006543001734 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1006543001735 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1006543001736 Cna protein B-type domain; Region: Cna_B; pfam05738 1006543001737 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543001738 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1006543001739 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1006543001740 Cna protein B-type domain; Region: Cna_B; pfam05738 1006543001741 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1006543001742 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1006543001743 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1006543001744 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1006543001745 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1006543001746 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1006543001747 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1006543001748 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1006543001749 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1006543001750 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1006543001751 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1006543001752 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1006543001753 active site 1006543001754 trimer interface [polypeptide binding]; other site 1006543001755 allosteric site; other site 1006543001756 active site lid [active] 1006543001757 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1006543001758 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1006543001759 active site 1006543001760 dimer interface [polypeptide binding]; other site 1006543001761 magnesium binding site [ion binding]; other site 1006543001762 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1006543001763 tetramer interface [polypeptide binding]; other site 1006543001764 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1006543001765 active site 1006543001766 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1006543001767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543001768 motif II; other site 1006543001769 proline/glycine betaine transporter; Provisional; Region: PRK10642 1006543001770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543001771 putative substrate translocation pore; other site 1006543001772 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1006543001773 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1006543001774 acyl-activating enzyme (AAE) consensus motif; other site 1006543001775 AMP binding site [chemical binding]; other site 1006543001776 active site 1006543001777 CoA binding site [chemical binding]; other site 1006543001778 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1006543001779 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1006543001780 dimer interface [polypeptide binding]; other site 1006543001781 active site 1006543001782 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1006543001783 dimer interface [polypeptide binding]; other site 1006543001784 substrate binding site [chemical binding]; other site 1006543001785 ATP binding site [chemical binding]; other site 1006543001786 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1006543001787 ligand binding site [chemical binding]; other site 1006543001788 active site 1006543001789 UGI interface [polypeptide binding]; other site 1006543001790 catalytic site [active] 1006543001791 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1006543001792 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1006543001793 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1006543001794 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1006543001795 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1006543001796 putative heme peroxidase; Provisional; Region: PRK12276 1006543001797 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1006543001798 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1006543001799 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543001800 MULE transposase domain; Region: MULE; pfam10551 1006543001801 mevalonate kinase; Region: mevalon_kin; TIGR00549 1006543001802 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1006543001803 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1006543001804 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1006543001805 diphosphomevalonate decarboxylase; Region: PLN02407 1006543001806 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1006543001807 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1006543001808 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1006543001809 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1006543001810 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1006543001811 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1006543001812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543001813 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1006543001814 Predicted transcriptional regulator [Transcription]; Region: COG1959 1006543001815 Transcriptional regulator; Region: Rrf2; pfam02082 1006543001816 LXG domain of WXG superfamily; Region: LXG; pfam04740 1006543001817 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1006543001818 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1006543001819 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1006543001820 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1006543001821 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1006543001822 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1006543001823 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1006543001824 active site 1006543001825 catalytic tetrad [active] 1006543001826 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1006543001827 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1006543001828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1006543001829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543001830 Coenzyme A binding pocket [chemical binding]; other site 1006543001831 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1006543001832 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1006543001833 Zn2+ binding site [ion binding]; other site 1006543001834 Mg2+ binding site [ion binding]; other site 1006543001835 YwhD family; Region: YwhD; pfam08741 1006543001836 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1006543001837 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1006543001838 NAD binding site [chemical binding]; other site 1006543001839 substrate binding site [chemical binding]; other site 1006543001840 catalytic Zn binding site [ion binding]; other site 1006543001841 tetramer interface [polypeptide binding]; other site 1006543001842 structural Zn binding site [ion binding]; other site 1006543001843 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1006543001844 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1006543001845 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1006543001846 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1006543001847 active site 1006543001848 HIGH motif; other site 1006543001849 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1006543001850 KMSK motif region; other site 1006543001851 tRNA binding surface [nucleotide binding]; other site 1006543001852 DALR anticodon binding domain; Region: DALR_1; smart00836 1006543001853 anticodon binding site; other site 1006543001854 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1006543001855 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1006543001856 minor groove reading motif; other site 1006543001857 helix-hairpin-helix signature motif; other site 1006543001858 substrate binding pocket [chemical binding]; other site 1006543001859 active site 1006543001860 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1006543001861 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1006543001862 putative binding site residues; other site 1006543001863 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1006543001864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543001865 ABC-ATPase subunit interface; other site 1006543001866 dimer interface [polypeptide binding]; other site 1006543001867 putative PBP binding regions; other site 1006543001868 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1006543001869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543001870 motif II; other site 1006543001871 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1006543001872 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1006543001873 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543001874 MULE transposase domain; Region: MULE; pfam10551 1006543001875 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1006543001876 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1006543001877 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543001878 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1006543001879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1006543001880 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1006543001881 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1006543001882 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1006543001883 active site 1006543001884 DNA binding site [nucleotide binding] 1006543001885 Int/Topo IB signature motif; other site 1006543001886 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1006543001887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1006543001888 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1006543001889 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1006543001890 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1006543001891 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1006543001892 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1006543001893 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1006543001894 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1006543001895 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1006543001896 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1006543001897 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1006543001898 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1006543001899 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1006543001900 metal binding site [ion binding]; metal-binding site 1006543001901 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1006543001902 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543001903 ABC-ATPase subunit interface; other site 1006543001904 dimer interface [polypeptide binding]; other site 1006543001905 putative PBP binding regions; other site 1006543001906 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1006543001907 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1006543001908 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1006543001909 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1006543001910 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1006543001911 FeoA domain; Region: FeoA; pfam04023 1006543001912 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1006543001913 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1006543001914 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1006543001915 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1006543001916 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1006543001917 Walker A/P-loop; other site 1006543001918 ATP binding site [chemical binding]; other site 1006543001919 Q-loop/lid; other site 1006543001920 ABC transporter signature motif; other site 1006543001921 Walker B; other site 1006543001922 D-loop; other site 1006543001923 H-loop/switch region; other site 1006543001924 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1006543001925 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1006543001926 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1006543001927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1006543001928 active site 1006543001929 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1006543001930 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1006543001931 active site 1006543001932 nucleotide binding site [chemical binding]; other site 1006543001933 HIGH motif; other site 1006543001934 KMSKS motif; other site 1006543001935 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1006543001936 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1006543001937 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1006543001938 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1006543001939 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1006543001940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543001941 Walker A/P-loop; other site 1006543001942 ATP binding site [chemical binding]; other site 1006543001943 Q-loop/lid; other site 1006543001944 ABC transporter signature motif; other site 1006543001945 Walker B; other site 1006543001946 D-loop; other site 1006543001947 H-loop/switch region; other site 1006543001948 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1006543001949 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1006543001950 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1006543001951 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1006543001952 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1006543001953 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1006543001954 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1006543001955 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1006543001956 Walker A/P-loop; other site 1006543001957 ATP binding site [chemical binding]; other site 1006543001958 Q-loop/lid; other site 1006543001959 ABC transporter signature motif; other site 1006543001960 Walker B; other site 1006543001961 D-loop; other site 1006543001962 H-loop/switch region; other site 1006543001963 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1006543001964 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543001965 ABC-ATPase subunit interface; other site 1006543001966 dimer interface [polypeptide binding]; other site 1006543001967 putative PBP binding regions; other site 1006543001968 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1006543001969 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543001970 ABC-ATPase subunit interface; other site 1006543001971 dimer interface [polypeptide binding]; other site 1006543001972 putative PBP binding regions; other site 1006543001973 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1006543001974 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1006543001975 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1006543001976 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1006543001977 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1006543001978 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1006543001979 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1006543001980 Na binding site [ion binding]; other site 1006543001981 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1006543001982 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1006543001983 substrate binding pocket [chemical binding]; other site 1006543001984 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1006543001985 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1006543001986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543001987 Coenzyme A binding pocket [chemical binding]; other site 1006543001988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1006543001989 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1006543001990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1006543001991 NAD(P) binding site [chemical binding]; other site 1006543001992 active site 1006543001993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1006543001994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543001995 active site 1006543001996 phosphorylation site [posttranslational modification] 1006543001997 intermolecular recognition site; other site 1006543001998 dimerization interface [polypeptide binding]; other site 1006543001999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1006543002000 DNA binding site [nucleotide binding] 1006543002001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1006543002002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1006543002003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543002004 ATP binding site [chemical binding]; other site 1006543002005 Mg2+ binding site [ion binding]; other site 1006543002006 G-X-G motif; other site 1006543002007 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1006543002008 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1006543002009 Walker A/P-loop; other site 1006543002010 ATP binding site [chemical binding]; other site 1006543002011 Q-loop/lid; other site 1006543002012 ABC transporter signature motif; other site 1006543002013 Walker B; other site 1006543002014 D-loop; other site 1006543002015 H-loop/switch region; other site 1006543002016 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1006543002017 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1006543002018 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1006543002019 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1006543002020 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1006543002021 Surface antigen [General function prediction only]; Region: COG3942 1006543002022 CHAP domain; Region: CHAP; pfam05257 1006543002023 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1006543002024 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1006543002025 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1006543002026 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543002027 hypothetical protein; Provisional; Region: PRK12378 1006543002028 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1006543002029 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1006543002030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1006543002031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1006543002032 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1006543002033 dimerization interface [polypeptide binding]; other site 1006543002034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543002035 sugar efflux transporter; Region: 2A0120; TIGR00899 1006543002036 putative substrate translocation pore; other site 1006543002037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1006543002038 Serine incorporator (Serinc); Region: Serinc; pfam03348 1006543002039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543002040 Coenzyme A binding pocket [chemical binding]; other site 1006543002041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1006543002042 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1006543002043 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1006543002044 hypothetical protein; Validated; Region: PRK00124 1006543002045 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1006543002046 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1006543002047 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1006543002048 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1006543002049 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1006543002050 Walker A/P-loop; other site 1006543002051 ATP binding site [chemical binding]; other site 1006543002052 Q-loop/lid; other site 1006543002053 ABC transporter signature motif; other site 1006543002054 Walker B; other site 1006543002055 D-loop; other site 1006543002056 H-loop/switch region; other site 1006543002057 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1006543002058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1006543002059 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1006543002060 Walker A/P-loop; other site 1006543002061 ATP binding site [chemical binding]; other site 1006543002062 Q-loop/lid; other site 1006543002063 ABC transporter signature motif; other site 1006543002064 Walker B; other site 1006543002065 D-loop; other site 1006543002066 H-loop/switch region; other site 1006543002067 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1006543002068 MarR family; Region: MarR; pfam01047 1006543002069 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1006543002070 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1006543002071 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1006543002072 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1006543002073 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1006543002074 active site 1006543002075 catalytic tetrad [active] 1006543002076 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1006543002077 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1006543002078 transmembrane helices; other site 1006543002079 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1006543002080 DNA photolyase; Region: DNA_photolyase; pfam00875 1006543002081 Predicted membrane protein [Function unknown]; Region: COG4330 1006543002082 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1006543002083 trimer interface [polypeptide binding]; other site 1006543002084 putative Zn binding site [ion binding]; other site 1006543002085 D-galactonate transporter; Region: 2A0114; TIGR00893 1006543002086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543002087 putative substrate translocation pore; other site 1006543002088 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1006543002089 putative deacylase active site [active] 1006543002090 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1006543002091 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1006543002092 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1006543002093 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1006543002094 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1006543002095 putative substrate binding site [chemical binding]; other site 1006543002096 putative ATP binding site [chemical binding]; other site 1006543002097 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1006543002098 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1006543002099 active site 1006543002100 phosphorylation site [posttranslational modification] 1006543002101 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1006543002102 active site 1006543002103 P-loop; other site 1006543002104 phosphorylation site [posttranslational modification] 1006543002105 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1006543002106 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1006543002107 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1006543002108 active site 1006543002109 dimer interface [polypeptide binding]; other site 1006543002110 Domain of unknown function DUF21; Region: DUF21; pfam01595 1006543002111 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1006543002112 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1006543002113 Transporter associated domain; Region: CorC_HlyC; pfam03471 1006543002114 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1006543002115 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1006543002116 active site 1006543002117 catalytic tetrad [active] 1006543002118 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1006543002119 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1006543002120 Ligand binding site; other site 1006543002121 Putative Catalytic site; other site 1006543002122 DXD motif; other site 1006543002123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1006543002124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1006543002125 dimer interface [polypeptide binding]; other site 1006543002126 phosphorylation site [posttranslational modification] 1006543002127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543002128 ATP binding site [chemical binding]; other site 1006543002129 Mg2+ binding site [ion binding]; other site 1006543002130 G-X-G motif; other site 1006543002131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1006543002132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543002133 active site 1006543002134 phosphorylation site [posttranslational modification] 1006543002135 intermolecular recognition site; other site 1006543002136 dimerization interface [polypeptide binding]; other site 1006543002137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1006543002138 DNA binding site [nucleotide binding] 1006543002139 DoxX; Region: DoxX; pfam07681 1006543002140 Electron transfer DM13; Region: DM13; pfam10517 1006543002141 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1006543002142 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1006543002143 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1006543002144 active site 1006543002145 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1006543002146 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1006543002147 Ligand Binding Site [chemical binding]; other site 1006543002148 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1006543002149 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1006543002150 glutamine binding [chemical binding]; other site 1006543002151 catalytic triad [active] 1006543002152 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1006543002153 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1006543002154 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1006543002155 substrate-cofactor binding pocket; other site 1006543002156 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1006543002157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543002158 catalytic residue [active] 1006543002159 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1006543002160 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1006543002161 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1006543002162 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1006543002163 Sulfatase; Region: Sulfatase; pfam00884 1006543002164 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1006543002165 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1006543002166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1006543002167 ABC transporter; Region: ABC_tran_2; pfam12848 1006543002168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1006543002169 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1006543002170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1006543002171 ATP binding site [chemical binding]; other site 1006543002172 putative Mg++ binding site [ion binding]; other site 1006543002173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1006543002174 nucleotide binding region [chemical binding]; other site 1006543002175 ATP-binding site [chemical binding]; other site 1006543002176 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1006543002177 HRDC domain; Region: HRDC; pfam00570 1006543002178 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1006543002179 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1006543002180 Walker A/P-loop; other site 1006543002181 ATP binding site [chemical binding]; other site 1006543002182 Q-loop/lid; other site 1006543002183 ABC transporter signature motif; other site 1006543002184 Walker B; other site 1006543002185 D-loop; other site 1006543002186 H-loop/switch region; other site 1006543002187 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1006543002188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543002189 dimer interface [polypeptide binding]; other site 1006543002190 conserved gate region; other site 1006543002191 ABC-ATPase subunit interface; other site 1006543002192 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1006543002193 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1006543002194 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1006543002195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1006543002196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543002197 homodimer interface [polypeptide binding]; other site 1006543002198 catalytic residue [active] 1006543002199 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1006543002200 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1006543002201 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1006543002202 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1006543002203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543002204 putative substrate translocation pore; other site 1006543002205 POT family; Region: PTR2; cl17359 1006543002206 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1006543002207 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1006543002208 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1006543002209 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1006543002210 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1006543002211 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1006543002212 active site 1006543002213 dimer interface [polypeptide binding]; other site 1006543002214 catalytic residues [active] 1006543002215 effector binding site; other site 1006543002216 R2 peptide binding site; other site 1006543002217 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1006543002218 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1006543002219 dimer interface [polypeptide binding]; other site 1006543002220 putative radical transfer pathway; other site 1006543002221 diiron center [ion binding]; other site 1006543002222 tyrosyl radical; other site 1006543002223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543002224 ABC-ATPase subunit interface; other site 1006543002225 dimer interface [polypeptide binding]; other site 1006543002226 putative PBP binding regions; other site 1006543002227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543002228 ABC-ATPase subunit interface; other site 1006543002229 dimer interface [polypeptide binding]; other site 1006543002230 putative PBP binding regions; other site 1006543002231 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1006543002232 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1006543002233 Walker A/P-loop; other site 1006543002234 ATP binding site [chemical binding]; other site 1006543002235 Q-loop/lid; other site 1006543002236 ABC transporter signature motif; other site 1006543002237 Walker B; other site 1006543002238 D-loop; other site 1006543002239 H-loop/switch region; other site 1006543002240 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1006543002241 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1006543002242 putative ligand binding residues [chemical binding]; other site 1006543002243 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1006543002244 CHY zinc finger; Region: zf-CHY; pfam05495 1006543002245 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1006543002246 FAD binding domain; Region: FAD_binding_4; pfam01565 1006543002247 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1006543002248 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1006543002249 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1006543002250 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1006543002251 peptidase T; Region: peptidase-T; TIGR01882 1006543002252 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1006543002253 metal binding site [ion binding]; metal-binding site 1006543002254 dimer interface [polypeptide binding]; other site 1006543002255 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1006543002256 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1006543002257 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1006543002258 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1006543002259 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1006543002260 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1006543002261 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1006543002262 metal binding site [ion binding]; metal-binding site 1006543002263 active site 1006543002264 I-site; other site 1006543002265 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1006543002266 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1006543002267 Mg++ binding site [ion binding]; other site 1006543002268 putative catalytic motif [active] 1006543002269 substrate binding site [chemical binding]; other site 1006543002270 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1006543002271 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1006543002272 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1006543002273 EDD domain protein, DegV family; Region: DegV; TIGR00762 1006543002274 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1006543002275 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1006543002276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1006543002277 ATP binding site [chemical binding]; other site 1006543002278 putative Mg++ binding site [ion binding]; other site 1006543002279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1006543002280 nucleotide binding region [chemical binding]; other site 1006543002281 ATP-binding site [chemical binding]; other site 1006543002282 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1006543002283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1006543002284 active site 1006543002285 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1006543002286 30S subunit binding site; other site 1006543002287 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1006543002288 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1006543002289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1006543002290 nucleotide binding region [chemical binding]; other site 1006543002291 ATP-binding site [chemical binding]; other site 1006543002292 SEC-C motif; Region: SEC-C; pfam02810 1006543002293 peptide chain release factor 2; Provisional; Region: PRK06746 1006543002294 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1006543002295 RF-1 domain; Region: RF-1; pfam00472 1006543002296 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1006543002297 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1006543002298 Surface antigen [General function prediction only]; Region: COG3942 1006543002299 CHAP domain; Region: CHAP; pfam05257 1006543002300 HD domain; Region: HD_3; cl17350 1006543002301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 1006543002302 excinuclease ABC subunit B; Provisional; Region: PRK05298 1006543002303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1006543002304 ATP binding site [chemical binding]; other site 1006543002305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1006543002306 nucleotide binding region [chemical binding]; other site 1006543002307 ATP-binding site [chemical binding]; other site 1006543002308 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1006543002309 UvrB/uvrC motif; Region: UVR; pfam02151 1006543002310 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1006543002311 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1006543002312 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1006543002313 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1006543002314 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1006543002315 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1006543002316 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1006543002317 Hpr binding site; other site 1006543002318 active site 1006543002319 homohexamer subunit interaction site [polypeptide binding]; other site 1006543002320 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1006543002321 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1006543002322 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1006543002323 trimer interface [polypeptide binding]; other site 1006543002324 active site 1006543002325 substrate binding site [chemical binding]; other site 1006543002326 CoA binding site [chemical binding]; other site 1006543002327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1006543002328 binding surface 1006543002329 TPR motif; other site 1006543002330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1006543002331 TPR motif; other site 1006543002332 binding surface 1006543002333 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1006543002334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1006543002335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543002336 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1006543002337 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1006543002338 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1006543002339 phosphate binding site [ion binding]; other site 1006543002340 dimer interface [polypeptide binding]; other site 1006543002341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1006543002342 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1006543002343 Clp protease; Region: CLP_protease; pfam00574 1006543002344 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1006543002345 oligomer interface [polypeptide binding]; other site 1006543002346 active site residues [active] 1006543002347 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1006543002348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1006543002349 NAD(P) binding site [chemical binding]; other site 1006543002350 active site 1006543002351 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1006543002352 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1006543002353 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1006543002354 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1006543002355 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1006543002356 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1006543002357 Phosphoglycerate kinase; Region: PGK; pfam00162 1006543002358 substrate binding site [chemical binding]; other site 1006543002359 hinge regions; other site 1006543002360 ADP binding site [chemical binding]; other site 1006543002361 catalytic site [active] 1006543002362 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1006543002363 triosephosphate isomerase; Provisional; Region: PRK14565 1006543002364 substrate binding site [chemical binding]; other site 1006543002365 dimer interface [polypeptide binding]; other site 1006543002366 catalytic triad [active] 1006543002367 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1006543002368 phosphoglyceromutase; Provisional; Region: PRK05434 1006543002369 enolase; Provisional; Region: eno; PRK00077 1006543002370 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1006543002371 dimer interface [polypeptide binding]; other site 1006543002372 metal binding site [ion binding]; metal-binding site 1006543002373 substrate binding pocket [chemical binding]; other site 1006543002374 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1006543002375 Esterase/lipase [General function prediction only]; Region: COG1647 1006543002376 Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735 1006543002377 ribonuclease R; Region: RNase_R; TIGR02063 1006543002378 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1006543002379 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1006543002380 RNB domain; Region: RNB; pfam00773 1006543002381 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1006543002382 RNA binding site [nucleotide binding]; other site 1006543002383 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1006543002384 SmpB-tmRNA interface; other site 1006543002385 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1006543002386 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1006543002387 Int/Topo IB signature motif; other site 1006543002388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543002389 non-specific DNA binding site [nucleotide binding]; other site 1006543002390 salt bridge; other site 1006543002391 sequence-specific DNA binding site [nucleotide binding]; other site 1006543002392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1006543002393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543002394 salt bridge; other site 1006543002395 non-specific DNA binding site [nucleotide binding]; other site 1006543002396 sequence-specific DNA binding site [nucleotide binding]; other site 1006543002397 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 1006543002398 Uncharacterized conserved protein [Function unknown]; Region: COG4983 1006543002399 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 1006543002400 D5 N terminal like; Region: D5_N; smart00885 1006543002401 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1006543002402 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1006543002403 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1006543002404 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1006543002405 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1006543002406 gating phenylalanine in ion channel; other site 1006543002407 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543002408 MULE transposase domain; Region: MULE; pfam10551 1006543002409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543002410 Coenzyme A binding pocket [chemical binding]; other site 1006543002411 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543002412 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1006543002413 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1006543002414 Staphylococcal nuclease homologues; Region: SNc; smart00318 1006543002415 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1006543002416 Catalytic site; other site 1006543002417 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1006543002418 DNA-binding site [nucleotide binding]; DNA binding site 1006543002419 RNA-binding motif; other site 1006543002420 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1006543002421 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1006543002422 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1006543002423 catalytic core [active] 1006543002424 Lysine efflux permease [General function prediction only]; Region: COG1279 1006543002425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1006543002426 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1006543002427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1006543002428 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1006543002429 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1006543002430 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1006543002431 active site 1006543002432 catalytic residue [active] 1006543002433 dimer interface [polypeptide binding]; other site 1006543002434 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1006543002435 putative FMN binding site [chemical binding]; other site 1006543002436 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1006543002437 catalytic residues [active] 1006543002438 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1006543002439 ArsC family; Region: ArsC; pfam03960 1006543002440 putative ArsC-like catalytic residues; other site 1006543002441 putative TRX-like catalytic residues [active] 1006543002442 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1006543002443 lipoyl attachment site [posttranslational modification]; other site 1006543002444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1006543002445 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1006543002446 putative active site [active] 1006543002447 putative metal binding site [ion binding]; other site 1006543002448 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1006543002449 catalytic residues [active] 1006543002450 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1006543002451 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1006543002452 Walker A/P-loop; other site 1006543002453 ATP binding site [chemical binding]; other site 1006543002454 Q-loop/lid; other site 1006543002455 ABC transporter signature motif; other site 1006543002456 Walker B; other site 1006543002457 D-loop; other site 1006543002458 H-loop/switch region; other site 1006543002459 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1006543002460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543002461 dimer interface [polypeptide binding]; other site 1006543002462 conserved gate region; other site 1006543002463 ABC-ATPase subunit interface; other site 1006543002464 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1006543002465 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1006543002466 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1006543002467 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1006543002468 Int/Topo IB signature motif; other site 1006543002469 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1006543002470 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543002471 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1006543002472 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543002473 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1006543002474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543002475 non-specific DNA binding site [nucleotide binding]; other site 1006543002476 salt bridge; other site 1006543002477 sequence-specific DNA binding site [nucleotide binding]; other site 1006543002478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543002479 non-specific DNA binding site [nucleotide binding]; other site 1006543002480 salt bridge; other site 1006543002481 sequence-specific DNA binding site [nucleotide binding]; other site 1006543002482 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1006543002483 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 1006543002484 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1006543002485 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1006543002486 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1006543002487 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1006543002488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1006543002489 Predicted membrane protein [Function unknown]; Region: COG2035 1006543002490 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1006543002491 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1006543002492 Walker A/P-loop; other site 1006543002493 ATP binding site [chemical binding]; other site 1006543002494 Q-loop/lid; other site 1006543002495 ABC transporter signature motif; other site 1006543002496 Walker B; other site 1006543002497 D-loop; other site 1006543002498 H-loop/switch region; other site 1006543002499 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1006543002500 FeS assembly protein SufD; Region: sufD; TIGR01981 1006543002501 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1006543002502 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1006543002503 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1006543002504 catalytic residue [active] 1006543002505 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1006543002506 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1006543002507 trimerization site [polypeptide binding]; other site 1006543002508 active site 1006543002509 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1006543002510 FeS assembly protein SufB; Region: sufB; TIGR01980 1006543002511 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1006543002512 Domain of unknown function DUF21; Region: DUF21; pfam01595 1006543002513 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1006543002514 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1006543002515 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1006543002516 FMN binding site [chemical binding]; other site 1006543002517 substrate binding site [chemical binding]; other site 1006543002518 putative catalytic residue [active] 1006543002519 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1006543002520 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1006543002521 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1006543002522 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1006543002523 active site 1006543002524 metal binding site [ion binding]; metal-binding site 1006543002525 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1006543002526 lipoyl synthase; Provisional; Region: PRK05481 1006543002527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543002528 FeS/SAM binding site; other site 1006543002529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1006543002530 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1006543002531 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1006543002532 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1006543002533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543002534 active site 1006543002535 motif I; other site 1006543002536 motif II; other site 1006543002537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543002538 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1006543002539 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1006543002540 dimerization interface [polypeptide binding]; other site 1006543002541 ligand binding site [chemical binding]; other site 1006543002542 NADP binding site [chemical binding]; other site 1006543002543 catalytic site [active] 1006543002544 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1006543002545 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1006543002546 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1006543002547 acyl-activating enzyme (AAE) consensus motif; other site 1006543002548 AMP binding site [chemical binding]; other site 1006543002549 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1006543002550 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1006543002551 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1006543002552 DltD N-terminal region; Region: DltD_N; pfam04915 1006543002553 DltD central region; Region: DltD_M; pfam04918 1006543002554 DltD C-terminal region; Region: DltD_C; pfam04914 1006543002555 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1006543002556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1006543002557 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1006543002558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543002559 hypothetical protein; Provisional; Region: PRK13669 1006543002560 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1006543002561 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1006543002562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543002563 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1006543002564 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1006543002565 interface (dimer of trimers) [polypeptide binding]; other site 1006543002566 Substrate-binding/catalytic site; other site 1006543002567 Zn-binding sites [ion binding]; other site 1006543002568 Predicted permease [General function prediction only]; Region: COG2056 1006543002569 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1006543002570 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1006543002571 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1006543002572 CoenzymeA binding site [chemical binding]; other site 1006543002573 subunit interaction site [polypeptide binding]; other site 1006543002574 PHB binding site; other site 1006543002575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1006543002576 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1006543002577 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1006543002578 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1006543002579 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 1006543002580 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1006543002581 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1006543002582 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1006543002583 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1006543002584 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1006543002585 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1006543002586 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1006543002587 Kinase associated protein B; Region: KapB; pfam08810 1006543002588 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1006543002589 active site 1006543002590 general stress protein 13; Validated; Region: PRK08059 1006543002591 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1006543002592 RNA binding site [nucleotide binding]; other site 1006543002593 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1006543002594 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1006543002595 putative active site [active] 1006543002596 putative FMN binding site [chemical binding]; other site 1006543002597 putative substrate binding site [chemical binding]; other site 1006543002598 putative catalytic residue [active] 1006543002599 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1006543002600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1006543002601 inhibitor-cofactor binding pocket; inhibition site 1006543002602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543002603 catalytic residue [active] 1006543002604 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1006543002605 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1006543002606 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1006543002607 NAD(P) binding site [chemical binding]; other site 1006543002608 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1006543002609 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1006543002610 active site 1006543002611 catalytic site [active] 1006543002612 argininosuccinate lyase; Provisional; Region: PRK00855 1006543002613 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1006543002614 active sites [active] 1006543002615 tetramer interface [polypeptide binding]; other site 1006543002616 argininosuccinate synthase; Provisional; Region: PRK13820 1006543002617 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1006543002618 ANP binding site [chemical binding]; other site 1006543002619 Substrate Binding Site II [chemical binding]; other site 1006543002620 Substrate Binding Site I [chemical binding]; other site 1006543002621 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1006543002622 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1006543002623 active site 1006543002624 dimer interface [polypeptide binding]; other site 1006543002625 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1006543002626 dimer interface [polypeptide binding]; other site 1006543002627 active site 1006543002628 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1006543002629 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1006543002630 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1006543002631 Catalytic site [active] 1006543002632 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1006543002633 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1006543002634 Catalytic site [active] 1006543002635 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1006543002636 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1006543002637 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1006543002638 Part of AAA domain; Region: AAA_19; pfam13245 1006543002639 Family description; Region: UvrD_C_2; pfam13538 1006543002640 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1006543002641 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1006543002642 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1006543002643 hypothetical protein; Provisional; Region: PRK13673 1006543002644 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1006543002645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1006543002646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543002647 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1006543002648 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1006543002649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543002650 active site 1006543002651 motif I; other site 1006543002652 motif II; other site 1006543002653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543002654 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1006543002655 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1006543002656 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1006543002657 catalytic triad [active] 1006543002658 catalytic triad [active] 1006543002659 oxyanion hole [active] 1006543002660 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1006543002661 Clp amino terminal domain; Region: Clp_N; pfam02861 1006543002662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543002663 Walker A motif; other site 1006543002664 ATP binding site [chemical binding]; other site 1006543002665 Walker B motif; other site 1006543002666 arginine finger; other site 1006543002667 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1006543002668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543002669 Walker A motif; other site 1006543002670 ATP binding site [chemical binding]; other site 1006543002671 Walker B motif; other site 1006543002672 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1006543002673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1006543002674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1006543002675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1006543002676 dimerization interface [polypeptide binding]; other site 1006543002677 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1006543002678 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1006543002679 active site 1006543002680 catalytic residues [active] 1006543002681 metal binding site [ion binding]; metal-binding site 1006543002682 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1006543002683 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1006543002684 substrate binding site [chemical binding]; other site 1006543002685 MAP domain; Region: MAP; pfam03642 1006543002686 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1006543002687 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1006543002688 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1006543002689 dimer interface [polypeptide binding]; other site 1006543002690 active site 1006543002691 CoA binding pocket [chemical binding]; other site 1006543002692 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1006543002693 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1006543002694 dimer interface [polypeptide binding]; other site 1006543002695 active site 1006543002696 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1006543002697 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1006543002698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543002699 dimer interface [polypeptide binding]; other site 1006543002700 conserved gate region; other site 1006543002701 putative PBP binding loops; other site 1006543002702 ABC-ATPase subunit interface; other site 1006543002703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1006543002704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543002705 dimer interface [polypeptide binding]; other site 1006543002706 conserved gate region; other site 1006543002707 putative PBP binding loops; other site 1006543002708 ABC-ATPase subunit interface; other site 1006543002709 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1006543002710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543002711 Walker A/P-loop; other site 1006543002712 ATP binding site [chemical binding]; other site 1006543002713 Q-loop/lid; other site 1006543002714 ABC transporter signature motif; other site 1006543002715 Walker B; other site 1006543002716 D-loop; other site 1006543002717 H-loop/switch region; other site 1006543002718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1006543002719 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1006543002720 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543002721 Walker A/P-loop; other site 1006543002722 ATP binding site [chemical binding]; other site 1006543002723 Q-loop/lid; other site 1006543002724 ABC transporter signature motif; other site 1006543002725 Walker B; other site 1006543002726 D-loop; other site 1006543002727 H-loop/switch region; other site 1006543002728 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1006543002729 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1006543002730 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1006543002731 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1006543002732 peptide binding site [polypeptide binding]; other site 1006543002733 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1006543002734 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1006543002735 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1006543002736 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543002737 Walker A/P-loop; other site 1006543002738 ATP binding site [chemical binding]; other site 1006543002739 Q-loop/lid; other site 1006543002740 ABC transporter signature motif; other site 1006543002741 Walker B; other site 1006543002742 D-loop; other site 1006543002743 H-loop/switch region; other site 1006543002744 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1006543002745 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1006543002746 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543002747 Walker A/P-loop; other site 1006543002748 ATP binding site [chemical binding]; other site 1006543002749 Q-loop/lid; other site 1006543002750 ABC transporter signature motif; other site 1006543002751 Walker B; other site 1006543002752 D-loop; other site 1006543002753 H-loop/switch region; other site 1006543002754 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1006543002755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1006543002756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543002757 conserved gate region; other site 1006543002758 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543002759 MULE transposase domain; Region: MULE; pfam10551 1006543002760 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1006543002761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1006543002762 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1006543002763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543002764 dimer interface [polypeptide binding]; other site 1006543002765 conserved gate region; other site 1006543002766 putative PBP binding loops; other site 1006543002767 ABC-ATPase subunit interface; other site 1006543002768 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1006543002769 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1006543002770 active site 1006543002771 HIGH motif; other site 1006543002772 dimer interface [polypeptide binding]; other site 1006543002773 KMSKS motif; other site 1006543002774 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1006543002775 ArsC family; Region: ArsC; pfam03960 1006543002776 putative catalytic residues [active] 1006543002777 thiol/disulfide switch; other site 1006543002778 adaptor protein; Provisional; Region: PRK02315 1006543002779 Competence protein CoiA-like family; Region: CoiA; cl11541 1006543002780 Competence protein CoiA-like family; Region: CoiA; cl11541 1006543002781 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1006543002782 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1006543002783 active site 1006543002784 Zn binding site [ion binding]; other site 1006543002785 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1006543002786 Thioredoxin; Region: Thioredoxin_5; pfam13743 1006543002787 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1006543002788 apolar tunnel; other site 1006543002789 heme binding site [chemical binding]; other site 1006543002790 dimerization interface [polypeptide binding]; other site 1006543002791 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1006543002792 putative active site [active] 1006543002793 putative metal binding residues [ion binding]; other site 1006543002794 signature motif; other site 1006543002795 putative triphosphate binding site [ion binding]; other site 1006543002796 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1006543002797 synthetase active site [active] 1006543002798 NTP binding site [chemical binding]; other site 1006543002799 metal binding site [ion binding]; metal-binding site 1006543002800 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1006543002801 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1006543002802 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1006543002803 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1006543002804 active site 1006543002805 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1006543002806 MgtE intracellular N domain; Region: MgtE_N; smart00924 1006543002807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1006543002808 Divalent cation transporter; Region: MgtE; pfam01769 1006543002809 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1006543002810 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1006543002811 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1006543002812 TrkA-N domain; Region: TrkA_N; pfam02254 1006543002813 TrkA-C domain; Region: TrkA_C; pfam02080 1006543002814 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543002815 MULE transposase domain; Region: MULE; pfam10551 1006543002816 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1006543002817 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1006543002818 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1006543002819 Putative esterase; Region: Esterase; pfam00756 1006543002820 hypothetical protein; Provisional; Region: PRK13679 1006543002821 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1006543002822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543002823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543002824 putative substrate translocation pore; other site 1006543002825 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1006543002826 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1006543002827 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1006543002828 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1006543002829 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1006543002830 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1006543002831 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1006543002832 YueH-like protein; Region: YueH; pfam14166 1006543002833 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1006543002834 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1006543002835 G1 box; other site 1006543002836 putative GEF interaction site [polypeptide binding]; other site 1006543002837 GTP/Mg2+ binding site [chemical binding]; other site 1006543002838 Switch I region; other site 1006543002839 G2 box; other site 1006543002840 G3 box; other site 1006543002841 Switch II region; other site 1006543002842 G4 box; other site 1006543002843 G5 box; other site 1006543002844 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1006543002845 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1006543002846 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1006543002847 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1006543002848 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1006543002849 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1006543002850 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1006543002851 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1006543002852 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1006543002853 active site 1006543002854 metal binding site [ion binding]; metal-binding site 1006543002855 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1006543002856 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1006543002857 IDEAL domain; Region: IDEAL; pfam08858 1006543002858 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1006543002859 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1006543002860 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1006543002861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1006543002862 CAAX protease self-immunity; Region: Abi; pfam02517 1006543002863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1006543002864 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1006543002865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1006543002866 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1006543002867 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1006543002868 Walker A/P-loop; other site 1006543002869 ATP binding site [chemical binding]; other site 1006543002870 Q-loop/lid; other site 1006543002871 ABC transporter signature motif; other site 1006543002872 Walker B; other site 1006543002873 D-loop; other site 1006543002874 H-loop/switch region; other site 1006543002875 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1006543002876 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1006543002877 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1006543002878 Predicted membrane protein [Function unknown]; Region: COG2259 1006543002879 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1006543002880 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1006543002881 siderophore binding site; other site 1006543002882 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1006543002883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543002884 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1006543002885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1006543002886 Coenzyme A binding pocket [chemical binding]; other site 1006543002887 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1006543002888 UbiA prenyltransferase family; Region: UbiA; pfam01040 1006543002889 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1006543002890 isochorismate synthases; Region: isochor_syn; TIGR00543 1006543002891 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1006543002892 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1006543002893 dimer interface [polypeptide binding]; other site 1006543002894 tetramer interface [polypeptide binding]; other site 1006543002895 PYR/PP interface [polypeptide binding]; other site 1006543002896 TPP binding site [chemical binding]; other site 1006543002897 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1006543002898 TPP-binding site; other site 1006543002899 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1006543002900 PGAP1-like protein; Region: PGAP1; pfam07819 1006543002901 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1006543002902 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1006543002903 substrate binding site [chemical binding]; other site 1006543002904 oxyanion hole (OAH) forming residues; other site 1006543002905 trimer interface [polypeptide binding]; other site 1006543002906 Staphostatin B; Region: Staphostatin_B; pfam09023 1006543002907 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1006543002908 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1006543002909 aminotransferase A; Validated; Region: PRK07683 1006543002910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1006543002911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543002912 homodimer interface [polypeptide binding]; other site 1006543002913 catalytic residue [active] 1006543002914 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1006543002915 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1006543002916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1006543002917 MarR family; Region: MarR; pfam01047 1006543002918 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1006543002919 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1006543002920 amidase catalytic site [active] 1006543002921 Zn binding residues [ion binding]; other site 1006543002922 substrate binding site [chemical binding]; other site 1006543002923 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1006543002924 Lysozyme subfamily 2; Region: LYZ2; smart00047 1006543002925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543002926 Coenzyme A binding pocket [chemical binding]; other site 1006543002927 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1006543002928 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1006543002929 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543002930 MULE transposase domain; Region: MULE; pfam10551 1006543002931 Beta-lactamase; Region: Beta-lactamase; pfam00144 1006543002932 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1006543002933 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1006543002934 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1006543002935 Subunit I/III interface [polypeptide binding]; other site 1006543002936 Subunit III/IV interface [polypeptide binding]; other site 1006543002937 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1006543002938 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1006543002939 D-pathway; other site 1006543002940 Putative ubiquinol binding site [chemical binding]; other site 1006543002941 Low-spin heme (heme b) binding site [chemical binding]; other site 1006543002942 Putative water exit pathway; other site 1006543002943 Binuclear center (heme o3/CuB) [ion binding]; other site 1006543002944 K-pathway; other site 1006543002945 Putative proton exit pathway; other site 1006543002946 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1006543002947 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1006543002948 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1006543002949 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1006543002950 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1006543002951 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1006543002952 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1006543002953 homodimer interface [polypeptide binding]; other site 1006543002954 NADP binding site [chemical binding]; other site 1006543002955 substrate binding site [chemical binding]; other site 1006543002956 AIR carboxylase; Region: AIRC; cl00310 1006543002957 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1006543002958 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1006543002959 NAD binding site [chemical binding]; other site 1006543002960 ATP-grasp domain; Region: ATP-grasp; pfam02222 1006543002961 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1006543002962 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1006543002963 ATP binding site [chemical binding]; other site 1006543002964 active site 1006543002965 substrate binding site [chemical binding]; other site 1006543002966 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1006543002967 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1006543002968 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1006543002969 putative active site [active] 1006543002970 catalytic triad [active] 1006543002971 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1006543002972 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1006543002973 dimerization interface [polypeptide binding]; other site 1006543002974 ATP binding site [chemical binding]; other site 1006543002975 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1006543002976 dimerization interface [polypeptide binding]; other site 1006543002977 ATP binding site [chemical binding]; other site 1006543002978 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1006543002979 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1006543002980 active site 1006543002981 tetramer interface [polypeptide binding]; other site 1006543002982 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1006543002983 active site 1006543002984 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1006543002985 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1006543002986 dimerization interface [polypeptide binding]; other site 1006543002987 putative ATP binding site [chemical binding]; other site 1006543002988 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1006543002989 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1006543002990 active site 1006543002991 substrate binding site [chemical binding]; other site 1006543002992 cosubstrate binding site; other site 1006543002993 catalytic site [active] 1006543002994 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1006543002995 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1006543002996 purine monophosphate binding site [chemical binding]; other site 1006543002997 dimer interface [polypeptide binding]; other site 1006543002998 putative catalytic residues [active] 1006543002999 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1006543003000 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1006543003001 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1006543003002 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1006543003003 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1006543003004 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1006543003005 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1006543003006 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1006543003007 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1006543003008 Walker A/P-loop; other site 1006543003009 ATP binding site [chemical binding]; other site 1006543003010 Q-loop/lid; other site 1006543003011 ABC transporter signature motif; other site 1006543003012 Walker B; other site 1006543003013 D-loop; other site 1006543003014 H-loop/switch region; other site 1006543003015 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1006543003016 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1006543003017 Walker A/P-loop; other site 1006543003018 ATP binding site [chemical binding]; other site 1006543003019 Q-loop/lid; other site 1006543003020 ABC transporter signature motif; other site 1006543003021 Walker B; other site 1006543003022 D-loop; other site 1006543003023 H-loop/switch region; other site 1006543003024 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1006543003025 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1006543003026 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1006543003027 putative RNA binding site [nucleotide binding]; other site 1006543003028 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1006543003029 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1006543003030 dimerization domain swap beta strand [polypeptide binding]; other site 1006543003031 regulatory protein interface [polypeptide binding]; other site 1006543003032 active site 1006543003033 regulatory phosphorylation site [posttranslational modification]; other site 1006543003034 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1006543003035 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1006543003036 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1006543003037 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1006543003038 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1006543003039 catalytic residues [active] 1006543003040 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1006543003041 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1006543003042 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1006543003043 TrkA-N domain; Region: TrkA_N; pfam02254 1006543003044 TrkA-C domain; Region: TrkA_C; pfam02080 1006543003045 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1006543003046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1006543003047 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1006543003048 hypothetical protein; Provisional; Region: PRK13667 1006543003049 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1006543003050 active site 1006543003051 catalytic residues [active] 1006543003052 metal binding site [ion binding]; metal-binding site 1006543003053 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1006543003054 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1006543003055 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1006543003056 TPP-binding site [chemical binding]; other site 1006543003057 tetramer interface [polypeptide binding]; other site 1006543003058 heterodimer interface [polypeptide binding]; other site 1006543003059 phosphorylation loop region [posttranslational modification] 1006543003060 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1006543003061 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1006543003062 alpha subunit interface [polypeptide binding]; other site 1006543003063 TPP binding site [chemical binding]; other site 1006543003064 heterodimer interface [polypeptide binding]; other site 1006543003065 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1006543003066 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1006543003067 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1006543003068 E3 interaction surface; other site 1006543003069 lipoyl attachment site [posttranslational modification]; other site 1006543003070 e3 binding domain; Region: E3_binding; pfam02817 1006543003071 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1006543003072 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1006543003073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1006543003074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543003075 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1006543003076 hypothetical protein; Provisional; Region: PRK04387 1006543003077 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1006543003078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543003079 non-specific DNA binding site [nucleotide binding]; other site 1006543003080 salt bridge; other site 1006543003081 sequence-specific DNA binding site [nucleotide binding]; other site 1006543003082 Cupin domain; Region: Cupin_2; pfam07883 1006543003083 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1006543003084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543003085 Walker A/P-loop; other site 1006543003086 ATP binding site [chemical binding]; other site 1006543003087 Q-loop/lid; other site 1006543003088 ABC transporter signature motif; other site 1006543003089 Walker B; other site 1006543003090 D-loop; other site 1006543003091 H-loop/switch region; other site 1006543003092 TOBE domain; Region: TOBE_2; pfam08402 1006543003093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543003094 putative PBP binding loops; other site 1006543003095 dimer interface [polypeptide binding]; other site 1006543003096 ABC-ATPase subunit interface; other site 1006543003097 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1006543003098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543003099 dimer interface [polypeptide binding]; other site 1006543003100 conserved gate region; other site 1006543003101 putative PBP binding loops; other site 1006543003102 ABC-ATPase subunit interface; other site 1006543003103 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1006543003104 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 1006543003105 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1006543003106 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1006543003107 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1006543003108 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1006543003109 manganese transport protein MntH; Reviewed; Region: PRK00701 1006543003110 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1006543003111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1006543003112 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1006543003113 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1006543003114 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1006543003115 active site 1006543003116 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1006543003117 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1006543003118 G1 box; other site 1006543003119 putative GEF interaction site [polypeptide binding]; other site 1006543003120 GTP/Mg2+ binding site [chemical binding]; other site 1006543003121 Switch I region; other site 1006543003122 G2 box; other site 1006543003123 G3 box; other site 1006543003124 Switch II region; other site 1006543003125 G4 box; other site 1006543003126 G5 box; other site 1006543003127 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1006543003128 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1006543003129 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1006543003130 hypothetical protein; Provisional; Region: PRK13666 1006543003131 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1006543003132 pyruvate carboxylase; Reviewed; Region: PRK12999 1006543003133 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1006543003134 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1006543003135 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1006543003136 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1006543003137 active site 1006543003138 catalytic residues [active] 1006543003139 metal binding site [ion binding]; metal-binding site 1006543003140 homodimer binding site [polypeptide binding]; other site 1006543003141 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1006543003142 carboxyltransferase (CT) interaction site; other site 1006543003143 biotinylation site [posttranslational modification]; other site 1006543003144 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1006543003145 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1006543003146 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1006543003147 UbiA prenyltransferase family; Region: UbiA; pfam01040 1006543003148 Predicted membrane protein [Function unknown]; Region: COG2322 1006543003149 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1006543003150 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1006543003151 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1006543003152 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1006543003153 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1006543003154 putative active site [active] 1006543003155 catalytic site [active] 1006543003156 putative metal binding site [ion binding]; other site 1006543003157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1006543003158 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1006543003159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543003160 S-adenosylmethionine binding site [chemical binding]; other site 1006543003161 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1006543003162 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1006543003163 active site 1006543003164 (T/H)XGH motif; other site 1006543003165 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1006543003166 hypothetical protein; Provisional; Region: PRK13670 1006543003167 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1006543003168 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1006543003169 heme uptake protein IsdB; Region: IsdB; TIGR03657 1006543003170 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543003171 NEAr Transporter domain; Region: NEAT; smart00725 1006543003172 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1006543003173 heme-binding site [chemical binding]; other site 1006543003174 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1006543003175 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1006543003176 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1006543003177 heme-binding site [chemical binding]; other site 1006543003178 heme uptake protein IsdC; Region: IsdC; TIGR03656 1006543003179 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1006543003180 heme-binding site [chemical binding]; other site 1006543003181 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1006543003182 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1006543003183 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1006543003184 intersubunit interface [polypeptide binding]; other site 1006543003185 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1006543003186 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543003187 ABC-ATPase subunit interface; other site 1006543003188 dimer interface [polypeptide binding]; other site 1006543003189 putative PBP binding regions; other site 1006543003190 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1006543003191 active site 1006543003192 catalytic site [active] 1006543003193 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 1006543003194 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543003195 MULE transposase domain; Region: MULE; pfam10551 1006543003196 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1006543003197 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1006543003198 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1006543003199 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1006543003200 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1006543003201 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1006543003202 dimer interface [polypeptide binding]; other site 1006543003203 motif 1; other site 1006543003204 active site 1006543003205 motif 2; other site 1006543003206 motif 3; other site 1006543003207 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1006543003208 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1006543003209 putative tRNA-binding site [nucleotide binding]; other site 1006543003210 B3/4 domain; Region: B3_4; pfam03483 1006543003211 tRNA synthetase B5 domain; Region: B5; smart00874 1006543003212 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1006543003213 dimer interface [polypeptide binding]; other site 1006543003214 motif 1; other site 1006543003215 motif 3; other site 1006543003216 motif 2; other site 1006543003217 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1006543003218 ribonuclease HIII; Provisional; Region: PRK00996 1006543003219 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1006543003220 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1006543003221 RNA/DNA hybrid binding site [nucleotide binding]; other site 1006543003222 active site 1006543003223 Cell division protein ZapA; Region: ZapA; cl01146 1006543003224 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1006543003225 Colicin V production protein; Region: Colicin_V; pfam02674 1006543003226 hypothetical protein; Provisional; Region: PRK08609 1006543003227 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1006543003228 active site 1006543003229 primer binding site [nucleotide binding]; other site 1006543003230 NTP binding site [chemical binding]; other site 1006543003231 metal binding triad [ion binding]; metal-binding site 1006543003232 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1006543003233 active site 1006543003234 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1006543003235 MutS domain III; Region: MutS_III; pfam05192 1006543003236 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1006543003237 Walker A/P-loop; other site 1006543003238 ATP binding site [chemical binding]; other site 1006543003239 Q-loop/lid; other site 1006543003240 ABC transporter signature motif; other site 1006543003241 Walker B; other site 1006543003242 D-loop; other site 1006543003243 H-loop/switch region; other site 1006543003244 Smr domain; Region: Smr; pfam01713 1006543003245 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1006543003246 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1006543003247 catalytic residues [active] 1006543003248 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1006543003249 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1006543003250 GIY-YIG motif/motif A; other site 1006543003251 active site 1006543003252 catalytic site [active] 1006543003253 putative DNA binding site [nucleotide binding]; other site 1006543003254 metal binding site [ion binding]; metal-binding site 1006543003255 UvrB/uvrC motif; Region: UVR; pfam02151 1006543003256 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1006543003257 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1006543003258 putative Iron-sulfur protein interface [polypeptide binding]; other site 1006543003259 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1006543003260 proximal heme binding site [chemical binding]; other site 1006543003261 distal heme binding site [chemical binding]; other site 1006543003262 putative dimer interface [polypeptide binding]; other site 1006543003263 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1006543003264 L-aspartate oxidase; Provisional; Region: PRK06175 1006543003265 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1006543003266 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1006543003267 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1006543003268 glutamate racemase; Provisional; Region: PRK00865 1006543003269 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1006543003270 active site 1006543003271 dimerization interface [polypeptide binding]; other site 1006543003272 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1006543003273 active site 1006543003274 metal binding site [ion binding]; metal-binding site 1006543003275 homotetramer interface [polypeptide binding]; other site 1006543003276 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1006543003277 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 1006543003278 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1006543003279 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1006543003280 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1006543003281 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543003282 MULE transposase domain; Region: MULE; pfam10551 1006543003283 superantigen-like protein; Reviewed; Region: PRK13350 1006543003284 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543003285 superantigen-like protein; Reviewed; Region: PRK13349 1006543003286 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543003287 superantigen-like protein; Reviewed; Region: PRK13043 1006543003288 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543003289 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1006543003290 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1006543003291 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1006543003292 carbamate kinase; Reviewed; Region: PRK12686 1006543003293 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1006543003294 putative substrate binding site [chemical binding]; other site 1006543003295 nucleotide binding site [chemical binding]; other site 1006543003296 nucleotide binding site [chemical binding]; other site 1006543003297 homodimer interface [polypeptide binding]; other site 1006543003298 Predicted membrane protein [Function unknown]; Region: COG1288 1006543003299 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1006543003300 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1006543003301 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1006543003302 gating phenylalanine in ion channel; other site 1006543003303 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1006543003304 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1006543003305 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1006543003306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543003307 motif II; other site 1006543003308 hypothetical protein; Provisional; Region: PRK13688 1006543003309 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1006543003310 Coenzyme A binding pocket [chemical binding]; other site 1006543003311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1006543003312 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1006543003313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1006543003314 MraZ protein; Region: MraZ; pfam02381 1006543003315 MraZ protein; Region: MraZ; pfam02381 1006543003316 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1006543003317 MraW methylase family; Region: Methyltransf_5; pfam01795 1006543003318 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1006543003319 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1006543003320 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1006543003321 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1006543003322 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1006543003323 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1006543003324 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1006543003325 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1006543003326 Mg++ binding site [ion binding]; other site 1006543003327 putative catalytic motif [active] 1006543003328 putative substrate binding site [chemical binding]; other site 1006543003329 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1006543003330 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1006543003331 NAD binding site [chemical binding]; other site 1006543003332 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1006543003333 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1006543003334 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1006543003335 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1006543003336 Cell division protein FtsQ; Region: FtsQ; pfam03799 1006543003337 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1006543003338 Cell division protein FtsA; Region: FtsA; smart00842 1006543003339 Cell division protein FtsA; Region: FtsA; pfam14450 1006543003340 cell division protein FtsZ; Validated; Region: PRK09330 1006543003341 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1006543003342 nucleotide binding site [chemical binding]; other site 1006543003343 SulA interaction site; other site 1006543003344 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1006543003345 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1006543003346 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1006543003347 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1006543003348 catalytic residue [active] 1006543003349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1006543003350 YGGT family; Region: YGGT; pfam02325 1006543003351 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1006543003352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1006543003353 RNA binding surface [nucleotide binding]; other site 1006543003354 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1006543003355 DivIVA domain; Region: DivI1A_domain; TIGR03544 1006543003356 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1006543003357 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1006543003358 HIGH motif; other site 1006543003359 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1006543003360 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1006543003361 active site 1006543003362 KMSKS motif; other site 1006543003363 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1006543003364 tRNA binding surface [nucleotide binding]; other site 1006543003365 anticodon binding site; other site 1006543003366 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1006543003367 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1006543003368 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1006543003369 active site 1006543003370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1006543003371 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1006543003372 lipoprotein signal peptidase; Provisional; Region: PRK14787 1006543003373 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1006543003374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1006543003375 RNA binding surface [nucleotide binding]; other site 1006543003376 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1006543003377 active site 1006543003378 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1006543003379 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1006543003380 uracil transporter; Provisional; Region: PRK10720 1006543003381 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1006543003382 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1006543003383 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1006543003384 dihydroorotase; Validated; Region: pyrC; PRK09357 1006543003385 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1006543003386 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1006543003387 active site 1006543003388 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1006543003389 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1006543003390 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1006543003391 catalytic site [active] 1006543003392 subunit interface [polypeptide binding]; other site 1006543003393 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1006543003394 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1006543003395 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1006543003396 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1006543003397 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1006543003398 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1006543003399 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1006543003400 IMP binding site; other site 1006543003401 dimer interface [polypeptide binding]; other site 1006543003402 interdomain contacts; other site 1006543003403 partial ornithine binding site; other site 1006543003404 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1006543003405 active site 1006543003406 dimer interface [polypeptide binding]; other site 1006543003407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1006543003408 active site 1006543003409 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1006543003410 dimer interface [polypeptide binding]; other site 1006543003411 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1006543003412 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1006543003413 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1006543003414 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1006543003415 catalytic site [active] 1006543003416 G-X2-G-X-G-K; other site 1006543003417 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1006543003418 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1006543003419 Flavoprotein; Region: Flavoprotein; pfam02441 1006543003420 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1006543003421 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1006543003422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1006543003423 ATP binding site [chemical binding]; other site 1006543003424 putative Mg++ binding site [ion binding]; other site 1006543003425 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1006543003426 nucleotide binding region [chemical binding]; other site 1006543003427 ATP-binding site [chemical binding]; other site 1006543003428 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1006543003429 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1006543003430 active site 1006543003431 catalytic residues [active] 1006543003432 metal binding site [ion binding]; metal-binding site 1006543003433 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1006543003434 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1006543003435 putative active site [active] 1006543003436 substrate binding site [chemical binding]; other site 1006543003437 putative cosubstrate binding site; other site 1006543003438 catalytic site [active] 1006543003439 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1006543003440 substrate binding site [chemical binding]; other site 1006543003441 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1006543003442 NusB family; Region: NusB; pfam01029 1006543003443 putative RNA binding site [nucleotide binding]; other site 1006543003444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543003445 S-adenosylmethionine binding site [chemical binding]; other site 1006543003446 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1006543003447 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543003448 FeS/SAM binding site; other site 1006543003449 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1006543003450 Protein phosphatase 2C; Region: PP2C; pfam00481 1006543003451 active site 1006543003452 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1006543003453 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1006543003454 active site 1006543003455 ATP binding site [chemical binding]; other site 1006543003456 substrate binding site [chemical binding]; other site 1006543003457 activation loop (A-loop); other site 1006543003458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1006543003459 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1006543003460 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1006543003461 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1006543003462 Predicted GTPases [General function prediction only]; Region: COG1162 1006543003463 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1006543003464 RNA binding site [nucleotide binding]; other site 1006543003465 homodimer interface [polypeptide binding]; other site 1006543003466 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1006543003467 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1006543003468 GTP/Mg2+ binding site [chemical binding]; other site 1006543003469 G4 box; other site 1006543003470 G5 box; other site 1006543003471 G1 box; other site 1006543003472 Switch I region; other site 1006543003473 G2 box; other site 1006543003474 G3 box; other site 1006543003475 Switch II region; other site 1006543003476 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1006543003477 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1006543003478 substrate binding site [chemical binding]; other site 1006543003479 hexamer interface [polypeptide binding]; other site 1006543003480 metal binding site [ion binding]; metal-binding site 1006543003481 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1006543003482 Thiamine pyrophosphokinase; Region: TPK; cd07995 1006543003483 active site 1006543003484 dimerization interface [polypeptide binding]; other site 1006543003485 thiamine binding site [chemical binding]; other site 1006543003486 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1006543003487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1006543003488 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1006543003489 DAK2 domain; Region: Dak2; pfam02734 1006543003490 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1006543003491 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1006543003492 generic binding surface II; other site 1006543003493 ssDNA binding site; other site 1006543003494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1006543003495 ATP binding site [chemical binding]; other site 1006543003496 putative Mg++ binding site [ion binding]; other site 1006543003497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1006543003498 nucleotide binding region [chemical binding]; other site 1006543003499 ATP-binding site [chemical binding]; other site 1006543003500 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1006543003501 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1006543003502 active site 2 [active] 1006543003503 active site 1 [active] 1006543003504 putative phosphate acyltransferase; Provisional; Region: PRK05331 1006543003505 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1006543003506 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1006543003507 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1006543003508 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1006543003509 NAD(P) binding site [chemical binding]; other site 1006543003510 homotetramer interface [polypeptide binding]; other site 1006543003511 homodimer interface [polypeptide binding]; other site 1006543003512 active site 1006543003513 acyl carrier protein; Provisional; Region: acpP; PRK00982 1006543003514 ribonuclease III; Reviewed; Region: rnc; PRK00102 1006543003515 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1006543003516 dimerization interface [polypeptide binding]; other site 1006543003517 active site 1006543003518 metal binding site [ion binding]; metal-binding site 1006543003519 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1006543003520 dsRNA binding site [nucleotide binding]; other site 1006543003521 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1006543003522 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1006543003523 Walker A/P-loop; other site 1006543003524 ATP binding site [chemical binding]; other site 1006543003525 Q-loop/lid; other site 1006543003526 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1006543003527 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1006543003528 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1006543003529 ABC transporter signature motif; other site 1006543003530 Walker B; other site 1006543003531 D-loop; other site 1006543003532 H-loop/switch region; other site 1006543003533 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1006543003534 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1006543003535 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1006543003536 P loop; other site 1006543003537 GTP binding site [chemical binding]; other site 1006543003538 putative DNA-binding protein; Validated; Region: PRK00118 1006543003539 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1006543003540 signal recognition particle protein; Provisional; Region: PRK10867 1006543003541 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1006543003542 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1006543003543 P loop; other site 1006543003544 GTP binding site [chemical binding]; other site 1006543003545 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1006543003546 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1006543003547 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1006543003548 RimM N-terminal domain; Region: RimM; pfam01782 1006543003549 PRC-barrel domain; Region: PRC; pfam05239 1006543003550 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1006543003551 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1006543003552 Predicted membrane protein [Function unknown]; Region: COG4485 1006543003553 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1006543003554 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1006543003555 GTP/Mg2+ binding site [chemical binding]; other site 1006543003556 G4 box; other site 1006543003557 G5 box; other site 1006543003558 G1 box; other site 1006543003559 Switch I region; other site 1006543003560 G2 box; other site 1006543003561 G3 box; other site 1006543003562 Switch II region; other site 1006543003563 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1006543003564 RNA/DNA hybrid binding site [nucleotide binding]; other site 1006543003565 active site 1006543003566 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1006543003567 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1006543003568 CoA-ligase; Region: Ligase_CoA; pfam00549 1006543003569 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1006543003570 CoA binding domain; Region: CoA_binding; pfam02629 1006543003571 CoA-ligase; Region: Ligase_CoA; pfam00549 1006543003572 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1006543003573 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1006543003574 CHAP domain; Region: CHAP; pfam05257 1006543003575 FemAB family; Region: FemAB; pfam02388 1006543003576 FemAB family; Region: FemAB; pfam02388 1006543003577 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1006543003578 DNA protecting protein DprA; Region: dprA; TIGR00732 1006543003579 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1006543003580 DNA topoisomerase I; Validated; Region: PRK05582 1006543003581 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1006543003582 active site 1006543003583 interdomain interaction site; other site 1006543003584 putative metal-binding site [ion binding]; other site 1006543003585 nucleotide binding site [chemical binding]; other site 1006543003586 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1006543003587 domain I; other site 1006543003588 DNA binding groove [nucleotide binding] 1006543003589 phosphate binding site [ion binding]; other site 1006543003590 domain II; other site 1006543003591 domain III; other site 1006543003592 nucleotide binding site [chemical binding]; other site 1006543003593 catalytic site [active] 1006543003594 domain IV; other site 1006543003595 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1006543003596 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1006543003597 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1006543003598 Glucose inhibited division protein A; Region: GIDA; pfam01134 1006543003599 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1006543003600 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1006543003601 active site 1006543003602 DNA binding site [nucleotide binding] 1006543003603 Int/Topo IB signature motif; other site 1006543003604 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1006543003605 active site 1006543003606 HslU subunit interaction site [polypeptide binding]; other site 1006543003607 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1006543003608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543003609 Walker A motif; other site 1006543003610 ATP binding site [chemical binding]; other site 1006543003611 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1006543003612 Walker B motif; other site 1006543003613 arginine finger; other site 1006543003614 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1006543003615 transcriptional repressor CodY; Validated; Region: PRK04158 1006543003616 CodY GAF-like domain; Region: CodY; pfam06018 1006543003617 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1006543003618 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1006543003619 rRNA interaction site [nucleotide binding]; other site 1006543003620 S8 interaction site; other site 1006543003621 putative laminin-1 binding site; other site 1006543003622 elongation factor Ts; Provisional; Region: tsf; PRK09377 1006543003623 UBA/TS-N domain; Region: UBA; pfam00627 1006543003624 Elongation factor TS; Region: EF_TS; pfam00889 1006543003625 Elongation factor TS; Region: EF_TS; pfam00889 1006543003626 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1006543003627 putative nucleotide binding site [chemical binding]; other site 1006543003628 uridine monophosphate binding site [chemical binding]; other site 1006543003629 homohexameric interface [polypeptide binding]; other site 1006543003630 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1006543003631 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1006543003632 hinge region; other site 1006543003633 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1006543003634 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1006543003635 catalytic residue [active] 1006543003636 putative FPP diphosphate binding site; other site 1006543003637 putative FPP binding hydrophobic cleft; other site 1006543003638 dimer interface [polypeptide binding]; other site 1006543003639 putative IPP diphosphate binding site; other site 1006543003640 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1006543003641 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1006543003642 RIP metalloprotease RseP; Region: TIGR00054 1006543003643 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1006543003644 active site 1006543003645 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1006543003646 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1006543003647 protein binding site [polypeptide binding]; other site 1006543003648 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1006543003649 putative substrate binding region [chemical binding]; other site 1006543003650 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1006543003651 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1006543003652 dimer interface [polypeptide binding]; other site 1006543003653 motif 1; other site 1006543003654 active site 1006543003655 motif 2; other site 1006543003656 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1006543003657 putative deacylase active site [active] 1006543003658 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1006543003659 active site 1006543003660 motif 3; other site 1006543003661 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1006543003662 anticodon binding site; other site 1006543003663 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1006543003664 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1006543003665 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1006543003666 generic binding surface II; other site 1006543003667 generic binding surface I; other site 1006543003668 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1006543003669 active site 1006543003670 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1006543003671 active site 1006543003672 catalytic site [active] 1006543003673 substrate binding site [chemical binding]; other site 1006543003674 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1006543003675 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1006543003676 Sm and related proteins; Region: Sm_like; cl00259 1006543003677 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1006543003678 putative oligomer interface [polypeptide binding]; other site 1006543003679 putative RNA binding site [nucleotide binding]; other site 1006543003680 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1006543003681 NusA N-terminal domain; Region: NusA_N; pfam08529 1006543003682 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1006543003683 RNA binding site [nucleotide binding]; other site 1006543003684 homodimer interface [polypeptide binding]; other site 1006543003685 NusA-like KH domain; Region: KH_5; pfam13184 1006543003686 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1006543003687 G-X-X-G motif; other site 1006543003688 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1006543003689 putative RNA binding cleft [nucleotide binding]; other site 1006543003690 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1006543003691 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1006543003692 translation initiation factor IF-2; Region: IF-2; TIGR00487 1006543003693 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1006543003694 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1006543003695 G1 box; other site 1006543003696 putative GEF interaction site [polypeptide binding]; other site 1006543003697 GTP/Mg2+ binding site [chemical binding]; other site 1006543003698 Switch I region; other site 1006543003699 G2 box; other site 1006543003700 G3 box; other site 1006543003701 Switch II region; other site 1006543003702 G4 box; other site 1006543003703 G5 box; other site 1006543003704 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1006543003705 Translation-initiation factor 2; Region: IF-2; pfam11987 1006543003706 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1006543003707 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1006543003708 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1006543003709 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1006543003710 RNA binding site [nucleotide binding]; other site 1006543003711 active site 1006543003712 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1006543003713 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1006543003714 active site 1006543003715 Riboflavin kinase; Region: Flavokinase; smart00904 1006543003716 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1006543003717 16S/18S rRNA binding site [nucleotide binding]; other site 1006543003718 S13e-L30e interaction site [polypeptide binding]; other site 1006543003719 25S rRNA binding site [nucleotide binding]; other site 1006543003720 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1006543003721 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1006543003722 RNase E interface [polypeptide binding]; other site 1006543003723 trimer interface [polypeptide binding]; other site 1006543003724 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1006543003725 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1006543003726 RNase E interface [polypeptide binding]; other site 1006543003727 trimer interface [polypeptide binding]; other site 1006543003728 active site 1006543003729 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1006543003730 putative nucleic acid binding region [nucleotide binding]; other site 1006543003731 G-X-X-G motif; other site 1006543003732 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1006543003733 RNA binding site [nucleotide binding]; other site 1006543003734 domain interface; other site 1006543003735 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1006543003736 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1006543003737 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1006543003738 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1006543003739 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1006543003740 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1006543003741 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1006543003742 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1006543003743 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1006543003744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1006543003745 DNA-binding site [nucleotide binding]; DNA binding site 1006543003746 UTRA domain; Region: UTRA; pfam07702 1006543003747 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1006543003748 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1006543003749 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1006543003750 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1006543003751 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1006543003752 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1006543003753 classical (c) SDRs; Region: SDR_c; cd05233 1006543003754 NAD(P) binding site [chemical binding]; other site 1006543003755 active site 1006543003756 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1006543003757 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1006543003758 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1006543003759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543003760 non-specific DNA binding site [nucleotide binding]; other site 1006543003761 salt bridge; other site 1006543003762 sequence-specific DNA binding site [nucleotide binding]; other site 1006543003763 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1006543003764 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1006543003765 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1006543003766 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1006543003767 putative MPT binding site; other site 1006543003768 recombinase A; Provisional; Region: recA; PRK09354 1006543003769 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1006543003770 hexamer interface [polypeptide binding]; other site 1006543003771 Walker A motif; other site 1006543003772 ATP binding site [chemical binding]; other site 1006543003773 Walker B motif; other site 1006543003774 phosphodiesterase; Provisional; Region: PRK12704 1006543003775 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1006543003776 Zn2+ binding site [ion binding]; other site 1006543003777 Mg2+ binding site [ion binding]; other site 1006543003778 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1006543003779 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1006543003780 putative active site [active] 1006543003781 metal binding site [ion binding]; metal-binding site 1006543003782 homodimer binding site [polypeptide binding]; other site 1006543003783 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1006543003784 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1006543003785 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1006543003786 dimer interface [polypeptide binding]; other site 1006543003787 PYR/PP interface [polypeptide binding]; other site 1006543003788 TPP binding site [chemical binding]; other site 1006543003789 substrate binding site [chemical binding]; other site 1006543003790 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1006543003791 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1006543003792 TPP-binding site [chemical binding]; other site 1006543003793 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1006543003794 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1006543003795 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1006543003796 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1006543003797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543003798 FeS/SAM binding site; other site 1006543003799 TRAM domain; Region: TRAM; pfam01938 1006543003800 Predicted membrane protein [Function unknown]; Region: COG4550 1006543003801 Predicted membrane protein [Function unknown]; Region: COG4732 1006543003802 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1006543003803 MutS domain I; Region: MutS_I; pfam01624 1006543003804 MutS domain II; Region: MutS_II; pfam05188 1006543003805 MutS domain III; Region: MutS_III; pfam05192 1006543003806 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1006543003807 Walker A/P-loop; other site 1006543003808 ATP binding site [chemical binding]; other site 1006543003809 Q-loop/lid; other site 1006543003810 ABC transporter signature motif; other site 1006543003811 Walker B; other site 1006543003812 D-loop; other site 1006543003813 H-loop/switch region; other site 1006543003814 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1006543003815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543003816 ATP binding site [chemical binding]; other site 1006543003817 Mg2+ binding site [ion binding]; other site 1006543003818 G-X-G motif; other site 1006543003819 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1006543003820 ATP binding site [chemical binding]; other site 1006543003821 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1006543003822 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 1006543003823 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1006543003824 amphipathic channel; other site 1006543003825 Asn-Pro-Ala signature motifs; other site 1006543003826 glycerol kinase; Provisional; Region: glpK; PRK00047 1006543003827 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1006543003828 N- and C-terminal domain interface [polypeptide binding]; other site 1006543003829 active site 1006543003830 MgATP binding site [chemical binding]; other site 1006543003831 catalytic site [active] 1006543003832 metal binding site [ion binding]; metal-binding site 1006543003833 glycerol binding site [chemical binding]; other site 1006543003834 homotetramer interface [polypeptide binding]; other site 1006543003835 homodimer interface [polypeptide binding]; other site 1006543003836 FBP binding site [chemical binding]; other site 1006543003837 protein IIAGlc interface [polypeptide binding]; other site 1006543003838 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1006543003839 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1006543003840 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1006543003841 PGAP1-like protein; Region: PGAP1; pfam07819 1006543003842 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1006543003843 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 1006543003844 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1006543003845 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1006543003846 bacterial Hfq-like; Region: Hfq; cd01716 1006543003847 hexamer interface [polypeptide binding]; other site 1006543003848 Sm1 motif; other site 1006543003849 RNA binding site [nucleotide binding]; other site 1006543003850 Sm2 motif; other site 1006543003851 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1006543003852 catalytic residues [active] 1006543003853 dimer interface [polypeptide binding]; other site 1006543003854 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1006543003855 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1006543003856 HflX GTPase family; Region: HflX; cd01878 1006543003857 G1 box; other site 1006543003858 GTP/Mg2+ binding site [chemical binding]; other site 1006543003859 Switch I region; other site 1006543003860 G2 box; other site 1006543003861 G3 box; other site 1006543003862 Switch II region; other site 1006543003863 G4 box; other site 1006543003864 G5 box; other site 1006543003865 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1006543003866 Aluminium resistance protein; Region: Alum_res; pfam06838 1006543003867 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1006543003868 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1006543003869 DNA binding residues [nucleotide binding] 1006543003870 putative dimer interface [polypeptide binding]; other site 1006543003871 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1006543003872 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1006543003873 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1006543003874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1006543003875 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1006543003876 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543003877 MULE transposase domain; Region: MULE; pfam10551 1006543003878 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1006543003879 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1006543003880 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1006543003881 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1006543003882 catalytic residue [active] 1006543003883 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1006543003884 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1006543003885 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1006543003886 putative active site [active] 1006543003887 catalytic site [active] 1006543003888 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1006543003889 putative active site [active] 1006543003890 catalytic site [active] 1006543003891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1006543003892 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1006543003893 Walker A/P-loop; other site 1006543003894 ATP binding site [chemical binding]; other site 1006543003895 Q-loop/lid; other site 1006543003896 ABC transporter signature motif; other site 1006543003897 Walker B; other site 1006543003898 D-loop; other site 1006543003899 H-loop/switch region; other site 1006543003900 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1006543003901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1006543003902 Histidine kinase; Region: HisKA_3; pfam07730 1006543003903 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1006543003904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1006543003905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543003906 active site 1006543003907 phosphorylation site [posttranslational modification] 1006543003908 intermolecular recognition site; other site 1006543003909 dimerization interface [polypeptide binding]; other site 1006543003910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1006543003911 DNA binding residues [nucleotide binding] 1006543003912 dimerization interface [polypeptide binding]; other site 1006543003913 Staphylococcal nuclease homologues; Region: SNc; smart00318 1006543003914 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1006543003915 Catalytic site; other site 1006543003916 AAA domain; Region: AAA_11; pfam13086 1006543003917 aspartate kinase; Reviewed; Region: PRK09034 1006543003918 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1006543003919 putative catalytic residues [active] 1006543003920 putative nucleotide binding site [chemical binding]; other site 1006543003921 putative aspartate binding site [chemical binding]; other site 1006543003922 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1006543003923 allosteric regulatory residue; other site 1006543003924 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1006543003925 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1006543003926 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1006543003927 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1006543003928 threonine synthase; Reviewed; Region: PRK06721 1006543003929 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1006543003930 homodimer interface [polypeptide binding]; other site 1006543003931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543003932 catalytic residue [active] 1006543003933 homoserine kinase; Provisional; Region: PRK01212 1006543003934 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1006543003935 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1006543003936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543003937 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1006543003938 active site 1006543003939 motif I; other site 1006543003940 motif II; other site 1006543003941 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1006543003942 lysine transporter; Provisional; Region: PRK10836 1006543003943 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1006543003944 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1006543003945 tetramer interface [polypeptide binding]; other site 1006543003946 heme binding pocket [chemical binding]; other site 1006543003947 NADPH binding site [chemical binding]; other site 1006543003948 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1006543003949 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1006543003950 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1006543003951 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1006543003952 active site 1006543003953 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1006543003954 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1006543003955 LexA repressor; Validated; Region: PRK00215 1006543003956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1006543003957 putative DNA binding site [nucleotide binding]; other site 1006543003958 putative Zn2+ binding site [ion binding]; other site 1006543003959 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1006543003960 Catalytic site [active] 1006543003961 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1006543003962 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1006543003963 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1006543003964 TPP-binding site [chemical binding]; other site 1006543003965 dimer interface [polypeptide binding]; other site 1006543003966 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1006543003967 PYR/PP interface [polypeptide binding]; other site 1006543003968 dimer interface [polypeptide binding]; other site 1006543003969 TPP binding site [chemical binding]; other site 1006543003970 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1006543003971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1006543003972 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1006543003973 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1006543003974 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1006543003975 active site 1006543003976 metal binding site [ion binding]; metal-binding site 1006543003977 DNA binding site [nucleotide binding] 1006543003978 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1006543003979 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1006543003980 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1006543003981 Walker A/P-loop; other site 1006543003982 ATP binding site [chemical binding]; other site 1006543003983 Q-loop/lid; other site 1006543003984 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1006543003985 ABC transporter signature motif; other site 1006543003986 Walker B; other site 1006543003987 D-loop; other site 1006543003988 H-loop/switch region; other site 1006543003989 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1006543003990 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1006543003991 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1006543003992 aconitate hydratase; Validated; Region: PRK09277 1006543003993 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1006543003994 substrate binding site [chemical binding]; other site 1006543003995 ligand binding site [chemical binding]; other site 1006543003996 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1006543003997 substrate binding site [chemical binding]; other site 1006543003998 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1006543003999 active site 1006543004000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1006543004001 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1006543004002 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1006543004003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543004004 ATP binding site [chemical binding]; other site 1006543004005 Mg2+ binding site [ion binding]; other site 1006543004006 G-X-G motif; other site 1006543004007 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1006543004008 anchoring element; other site 1006543004009 dimer interface [polypeptide binding]; other site 1006543004010 ATP binding site [chemical binding]; other site 1006543004011 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1006543004012 active site 1006543004013 putative metal-binding site [ion binding]; other site 1006543004014 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1006543004015 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1006543004016 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1006543004017 CAP-like domain; other site 1006543004018 active site 1006543004019 primary dimer interface [polypeptide binding]; other site 1006543004020 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1006543004021 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1006543004022 amino acid carrier protein; Region: agcS; TIGR00835 1006543004023 CAT RNA binding domain; Region: CAT_RBD; smart01061 1006543004024 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1006543004025 PRD domain; Region: PRD; pfam00874 1006543004026 PRD domain; Region: PRD; pfam00874 1006543004027 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1006543004028 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1006543004029 Predicted integral membrane protein [Function unknown]; Region: COG0392 1006543004030 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1006543004031 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1006543004032 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1006543004033 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1006543004034 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1006543004035 active site 1 [active] 1006543004036 dimer interface [polypeptide binding]; other site 1006543004037 hexamer interface [polypeptide binding]; other site 1006543004038 active site 2 [active] 1006543004039 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1006543004040 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1006543004041 active site 1006543004042 DNA binding site [nucleotide binding] 1006543004043 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1006543004044 prephenate dehydrogenase; Validated; Region: PRK06545 1006543004045 prephenate dehydrogenase; Validated; Region: PRK08507 1006543004046 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1006543004047 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1006543004048 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1006543004049 putative oligomer interface [polypeptide binding]; other site 1006543004050 putative active site [active] 1006543004051 metal binding site [ion binding]; metal-binding site 1006543004052 anthranilate synthase component I; Provisional; Region: PRK13567 1006543004053 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1006543004054 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1006543004055 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1006543004056 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1006543004057 glutamine binding [chemical binding]; other site 1006543004058 catalytic triad [active] 1006543004059 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1006543004060 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1006543004061 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1006543004062 active site 1006543004063 ribulose/triose binding site [chemical binding]; other site 1006543004064 phosphate binding site [ion binding]; other site 1006543004065 substrate (anthranilate) binding pocket [chemical binding]; other site 1006543004066 product (indole) binding pocket [chemical binding]; other site 1006543004067 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1006543004068 active site 1006543004069 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1006543004070 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1006543004071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543004072 catalytic residue [active] 1006543004073 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1006543004074 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1006543004075 substrate binding site [chemical binding]; other site 1006543004076 active site 1006543004077 catalytic residues [active] 1006543004078 heterodimer interface [polypeptide binding]; other site 1006543004079 FemAB family; Region: FemAB; pfam02388 1006543004080 FlxA-like protein; Region: FlxA; pfam14282 1006543004081 FemAB family; Region: FemAB; pfam02388 1006543004082 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1006543004083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543004084 active site 1006543004085 motif I; other site 1006543004086 motif II; other site 1006543004087 SWIM zinc finger; Region: SWIM; pfam04434 1006543004088 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1006543004089 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543004090 Walker A/P-loop; other site 1006543004091 ATP binding site [chemical binding]; other site 1006543004092 Q-loop/lid; other site 1006543004093 ABC transporter signature motif; other site 1006543004094 Walker B; other site 1006543004095 D-loop; other site 1006543004096 H-loop/switch region; other site 1006543004097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543004098 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1006543004099 Walker A/P-loop; other site 1006543004100 ATP binding site [chemical binding]; other site 1006543004101 Q-loop/lid; other site 1006543004102 ABC transporter signature motif; other site 1006543004103 Walker B; other site 1006543004104 D-loop; other site 1006543004105 H-loop/switch region; other site 1006543004106 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1006543004107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543004108 dimer interface [polypeptide binding]; other site 1006543004109 conserved gate region; other site 1006543004110 putative PBP binding loops; other site 1006543004111 ABC-ATPase subunit interface; other site 1006543004112 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1006543004113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543004114 dimer interface [polypeptide binding]; other site 1006543004115 conserved gate region; other site 1006543004116 putative PBP binding loops; other site 1006543004117 ABC-ATPase subunit interface; other site 1006543004118 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1006543004119 oligoendopeptidase F; Region: pepF; TIGR00181 1006543004120 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1006543004121 active site 1006543004122 Zn binding site [ion binding]; other site 1006543004123 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1006543004124 PhoU domain; Region: PhoU; pfam01895 1006543004125 PhoU domain; Region: PhoU; pfam01895 1006543004126 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1006543004127 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1006543004128 Walker A/P-loop; other site 1006543004129 ATP binding site [chemical binding]; other site 1006543004130 Q-loop/lid; other site 1006543004131 ABC transporter signature motif; other site 1006543004132 Walker B; other site 1006543004133 D-loop; other site 1006543004134 H-loop/switch region; other site 1006543004135 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1006543004136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543004137 dimer interface [polypeptide binding]; other site 1006543004138 conserved gate region; other site 1006543004139 putative PBP binding loops; other site 1006543004140 ABC-ATPase subunit interface; other site 1006543004141 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1006543004142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543004143 dimer interface [polypeptide binding]; other site 1006543004144 conserved gate region; other site 1006543004145 ABC-ATPase subunit interface; other site 1006543004146 phosphate binding protein; Region: ptsS_2; TIGR02136 1006543004147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1006543004148 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1006543004149 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1006543004150 S1 domain; Region: S1_2; pfam13509 1006543004151 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1006543004152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1006543004153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1006543004154 ABC transporter; Region: ABC_tran_2; pfam12848 1006543004155 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1006543004156 aspartate kinase; Reviewed; Region: PRK06635 1006543004157 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1006543004158 putative nucleotide binding site [chemical binding]; other site 1006543004159 putative catalytic residues [active] 1006543004160 putative Mg ion binding site [ion binding]; other site 1006543004161 putative aspartate binding site [chemical binding]; other site 1006543004162 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1006543004163 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1006543004164 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1006543004165 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1006543004166 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1006543004167 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1006543004168 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1006543004169 dimer interface [polypeptide binding]; other site 1006543004170 active site 1006543004171 catalytic residue [active] 1006543004172 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1006543004173 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1006543004174 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1006543004175 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1006543004176 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1006543004177 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1006543004178 active site 1006543004179 trimer interface [polypeptide binding]; other site 1006543004180 substrate binding site [chemical binding]; other site 1006543004181 CoA binding site [chemical binding]; other site 1006543004182 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1006543004183 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1006543004184 metal binding site [ion binding]; metal-binding site 1006543004185 dimer interface [polypeptide binding]; other site 1006543004186 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1006543004187 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1006543004188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1006543004189 catalytic residue [active] 1006543004190 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1006543004191 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1006543004192 active site 1006543004193 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1006543004194 substrate binding site [chemical binding]; other site 1006543004195 catalytic residues [active] 1006543004196 dimer interface [polypeptide binding]; other site 1006543004197 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1006543004198 DNA-binding site [nucleotide binding]; DNA binding site 1006543004199 RNA-binding motif; other site 1006543004200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1006543004201 acylphosphatase; Provisional; Region: PRK14431 1006543004202 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1006543004203 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1006543004204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1006543004205 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1006543004206 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1006543004207 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1006543004208 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1006543004209 metal ion-dependent adhesion site (MIDAS); other site 1006543004210 MoxR-like ATPases [General function prediction only]; Region: COG0714 1006543004211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543004212 Walker A motif; other site 1006543004213 ATP binding site [chemical binding]; other site 1006543004214 Walker B motif; other site 1006543004215 arginine finger; other site 1006543004216 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1006543004217 active site 1006543004218 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1006543004219 active site 1006543004220 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1006543004221 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1006543004222 E3 interaction surface; other site 1006543004223 lipoyl attachment site [posttranslational modification]; other site 1006543004224 e3 binding domain; Region: E3_binding; pfam02817 1006543004225 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1006543004226 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1006543004227 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1006543004228 TPP-binding site [chemical binding]; other site 1006543004229 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1006543004230 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1006543004231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1006543004232 HAMP domain; Region: HAMP; pfam00672 1006543004233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1006543004234 dimer interface [polypeptide binding]; other site 1006543004235 phosphorylation site [posttranslational modification] 1006543004236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543004237 ATP binding site [chemical binding]; other site 1006543004238 Mg2+ binding site [ion binding]; other site 1006543004239 G-X-G motif; other site 1006543004240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1006543004241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543004242 active site 1006543004243 phosphorylation site [posttranslational modification] 1006543004244 intermolecular recognition site; other site 1006543004245 dimerization interface [polypeptide binding]; other site 1006543004246 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1006543004247 DNA binding site [nucleotide binding] 1006543004248 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1006543004249 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1006543004250 active site 1006543004251 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1006543004252 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1006543004253 active site 1006543004254 homodimer interface [polypeptide binding]; other site 1006543004255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543004256 Coenzyme A binding pocket [chemical binding]; other site 1006543004257 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1006543004258 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1006543004259 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1006543004260 protein binding site [polypeptide binding]; other site 1006543004261 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1006543004262 Catalytic dyad [active] 1006543004263 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1006543004264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 1006543004265 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1006543004266 HPr interaction site; other site 1006543004267 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1006543004268 active site 1006543004269 phosphorylation site [posttranslational modification] 1006543004270 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1006543004271 SelR domain; Region: SelR; pfam01641 1006543004272 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1006543004273 EDD domain protein, DegV family; Region: DegV; TIGR00762 1006543004274 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1006543004275 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1006543004276 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1006543004277 folate binding site [chemical binding]; other site 1006543004278 NADP+ binding site [chemical binding]; other site 1006543004279 thymidylate synthase; Region: thym_sym; TIGR03284 1006543004280 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1006543004281 dimerization interface [polypeptide binding]; other site 1006543004282 active site 1006543004283 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1006543004284 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1006543004285 Virulence factor; Region: Virulence_fact; pfam13769 1006543004286 HEAT repeats; Region: HEAT_2; pfam13646 1006543004287 HEAT repeat; Region: HEAT; pfam02985 1006543004288 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1006543004289 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1006543004290 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1006543004291 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1006543004292 RNA/DNA hybrid binding site [nucleotide binding]; other site 1006543004293 active site 1006543004294 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543004295 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1006543004296 GA module; Region: GA; smart00844 1006543004297 GA module; Region: GA; smart00844 1006543004298 GA module; Region: GA; smart00844 1006543004299 GA module; Region: GA; smart00844 1006543004300 GA module; Region: GA; smart00844 1006543004301 GA module; Region: GA; smart00844 1006543004302 GA module; Region: GA; smart00844 1006543004303 GA module; Region: GA; smart00844 1006543004304 GA module; Region: GA; smart00844 1006543004305 GA module; Region: GA; smart00844 1006543004306 GA module; Region: GA; smart00844 1006543004307 GA module; Region: GA; smart00844 1006543004308 GA module; Region: GA; smart00844 1006543004309 GA module; Region: GA; smart00844 1006543004310 GA module; Region: GA; smart00844 1006543004311 GA module; Region: GA; smart00844 1006543004312 GA module; Region: GA; smart00844 1006543004313 GA module; Region: GA; smart00844 1006543004314 GA module; Region: GA; smart00844 1006543004315 GA module; Region: GA; pfam01468 1006543004316 GA module; Region: GA; smart00844 1006543004317 GA module; Region: GA; smart00844 1006543004318 GA module; Region: GA; smart00844 1006543004319 GA module; Region: GA; smart00844 1006543004320 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1006543004321 GA module; Region: GA; smart00844 1006543004322 GA module; Region: GA; smart00844 1006543004323 GA module; Region: GA; smart00844 1006543004324 GA module; Region: GA; smart00844 1006543004325 GA module; Region: GA; smart00844 1006543004326 GA module; Region: GA; smart00844 1006543004327 GA module; Region: GA; smart00844 1006543004328 GA module; Region: GA; pfam01468 1006543004329 GA module; Region: GA; smart00844 1006543004330 GA module; Region: GA; smart00844 1006543004331 GA module; Region: GA; smart00844 1006543004332 GA module; Region: GA; smart00844 1006543004333 GA module; Region: GA; smart00844 1006543004334 GA module; Region: GA; smart00844 1006543004335 GA module; Region: GA; smart00844 1006543004336 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1006543004337 GA module; Region: GA; smart00844 1006543004338 GA module; Region: GA; smart00844 1006543004339 GA module; Region: GA; smart00844 1006543004340 GA module; Region: GA; smart00844 1006543004341 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543004342 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543004343 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1006543004344 Amino acid permease; Region: AA_permease_2; pfam13520 1006543004345 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1006543004346 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1006543004347 tetramer interface [polypeptide binding]; other site 1006543004348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543004349 catalytic residue [active] 1006543004350 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1006543004351 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1006543004352 hexamer interface [polypeptide binding]; other site 1006543004353 ligand binding site [chemical binding]; other site 1006543004354 putative active site [active] 1006543004355 NAD(P) binding site [chemical binding]; other site 1006543004356 5'-3' exonuclease; Region: 53EXOc; smart00475 1006543004357 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1006543004358 active site 1006543004359 metal binding site 1 [ion binding]; metal-binding site 1006543004360 putative 5' ssDNA interaction site; other site 1006543004361 metal binding site 3; metal-binding site 1006543004362 metal binding site 2 [ion binding]; metal-binding site 1006543004363 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1006543004364 putative DNA binding site [nucleotide binding]; other site 1006543004365 putative metal binding site [ion binding]; other site 1006543004366 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1006543004367 Dynamin family; Region: Dynamin_N; pfam00350 1006543004368 G1 box; other site 1006543004369 GTP/Mg2+ binding site [chemical binding]; other site 1006543004370 G2 box; other site 1006543004371 Switch I region; other site 1006543004372 G3 box; other site 1006543004373 Switch II region; other site 1006543004374 G4 box; other site 1006543004375 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1006543004376 Dynamin family; Region: Dynamin_N; pfam00350 1006543004377 G1 box; other site 1006543004378 GTP/Mg2+ binding site [chemical binding]; other site 1006543004379 G2 box; other site 1006543004380 Switch I region; other site 1006543004381 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1006543004382 G3 box; other site 1006543004383 Switch II region; other site 1006543004384 GTP/Mg2+ binding site [chemical binding]; other site 1006543004385 G4 box; other site 1006543004386 G5 box; other site 1006543004387 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1006543004388 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1006543004389 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1006543004390 Cobalt transport protein component CbiN; Region: CbiN; cl00842 1006543004391 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1006543004392 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1006543004393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1006543004394 cell division protein GpsB; Provisional; Region: PRK14127 1006543004395 DivIVA domain; Region: DivI1A_domain; TIGR03544 1006543004396 hypothetical protein; Provisional; Region: PRK13660 1006543004397 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1006543004398 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1006543004399 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1006543004400 Transglycosylase; Region: Transgly; pfam00912 1006543004401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1006543004402 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1006543004403 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1006543004404 minor groove reading motif; other site 1006543004405 helix-hairpin-helix signature motif; other site 1006543004406 substrate binding pocket [chemical binding]; other site 1006543004407 active site 1006543004408 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1006543004409 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1006543004410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1006543004411 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1006543004412 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1006543004413 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1006543004414 putative dimer interface [polypeptide binding]; other site 1006543004415 putative anticodon binding site; other site 1006543004416 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1006543004417 homodimer interface [polypeptide binding]; other site 1006543004418 motif 1; other site 1006543004419 motif 2; other site 1006543004420 active site 1006543004421 motif 3; other site 1006543004422 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1006543004423 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1006543004424 active site 1006543004425 catalytic site [active] 1006543004426 substrate binding site [chemical binding]; other site 1006543004427 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1006543004428 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1006543004429 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1006543004430 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1006543004431 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1006543004432 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1006543004433 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1006543004434 active site 1006543004435 NTP binding site [chemical binding]; other site 1006543004436 metal binding triad [ion binding]; metal-binding site 1006543004437 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1006543004438 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1006543004439 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1006543004440 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1006543004441 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1006543004442 homodimer interface [polypeptide binding]; other site 1006543004443 metal binding site [ion binding]; metal-binding site 1006543004444 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1006543004445 Predicted membrane protein [Function unknown]; Region: COG4347 1006543004446 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1006543004447 UPF0302 domain; Region: UPF0302; pfam08864 1006543004448 A short protein domain of unknown function; Region: IDEAL; smart00914 1006543004449 TPR repeat; Region: TPR_11; pfam13414 1006543004450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1006543004451 binding surface 1006543004452 TPR motif; other site 1006543004453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1006543004454 TPR motif; other site 1006543004455 binding surface 1006543004456 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1006543004457 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1006543004458 hinge; other site 1006543004459 active site 1006543004460 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1006543004461 active site 1006543004462 NAD binding site [chemical binding]; other site 1006543004463 metal binding site [ion binding]; metal-binding site 1006543004464 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1006543004465 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1006543004466 Tetramer interface [polypeptide binding]; other site 1006543004467 active site 1006543004468 FMN-binding site [chemical binding]; other site 1006543004469 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1006543004470 active site 1006543004471 multimer interface [polypeptide binding]; other site 1006543004472 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1006543004473 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1006543004474 substrate binding pocket [chemical binding]; other site 1006543004475 chain length determination region; other site 1006543004476 substrate-Mg2+ binding site; other site 1006543004477 catalytic residues [active] 1006543004478 aspartate-rich region 1; other site 1006543004479 active site lid residues [active] 1006543004480 aspartate-rich region 2; other site 1006543004481 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1006543004482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543004483 S-adenosylmethionine binding site [chemical binding]; other site 1006543004484 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1006543004485 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1006543004486 IHF dimer interface [polypeptide binding]; other site 1006543004487 IHF - DNA interface [nucleotide binding]; other site 1006543004488 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1006543004489 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1006543004490 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1006543004491 GTP-binding protein Der; Reviewed; Region: PRK00093 1006543004492 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1006543004493 G1 box; other site 1006543004494 GTP/Mg2+ binding site [chemical binding]; other site 1006543004495 Switch I region; other site 1006543004496 G2 box; other site 1006543004497 Switch II region; other site 1006543004498 G3 box; other site 1006543004499 G4 box; other site 1006543004500 G5 box; other site 1006543004501 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1006543004502 G1 box; other site 1006543004503 GTP/Mg2+ binding site [chemical binding]; other site 1006543004504 Switch I region; other site 1006543004505 G2 box; other site 1006543004506 G3 box; other site 1006543004507 Switch II region; other site 1006543004508 G4 box; other site 1006543004509 G5 box; other site 1006543004510 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1006543004511 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1006543004512 RNA binding site [nucleotide binding]; other site 1006543004513 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1006543004514 RNA binding site [nucleotide binding]; other site 1006543004515 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1006543004516 RNA binding site [nucleotide binding]; other site 1006543004517 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1006543004518 RNA binding site [nucleotide binding]; other site 1006543004519 cytidylate kinase; Provisional; Region: cmk; PRK00023 1006543004520 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1006543004521 CMP-binding site; other site 1006543004522 The sites determining sugar specificity; other site 1006543004523 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1006543004524 active site 1006543004525 homotetramer interface [polypeptide binding]; other site 1006543004526 homodimer interface [polypeptide binding]; other site 1006543004527 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1006543004528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1006543004529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543004530 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1006543004531 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1006543004532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1006543004533 ATP binding site [chemical binding]; other site 1006543004534 putative Mg++ binding site [ion binding]; other site 1006543004535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1006543004536 nucleotide binding region [chemical binding]; other site 1006543004537 ATP-binding site [chemical binding]; other site 1006543004538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1006543004539 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1006543004540 Predicted membrane protein [Function unknown]; Region: COG3601 1006543004541 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1006543004542 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1006543004543 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1006543004544 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1006543004545 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1006543004546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1006543004547 dimerization interface [polypeptide binding]; other site 1006543004548 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1006543004549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1006543004550 dimer interface [polypeptide binding]; other site 1006543004551 phosphorylation site [posttranslational modification] 1006543004552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543004553 ATP binding site [chemical binding]; other site 1006543004554 Mg2+ binding site [ion binding]; other site 1006543004555 G-X-G motif; other site 1006543004556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1006543004557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543004558 active site 1006543004559 phosphorylation site [posttranslational modification] 1006543004560 intermolecular recognition site; other site 1006543004561 dimerization interface [polypeptide binding]; other site 1006543004562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1006543004563 DNA binding site [nucleotide binding] 1006543004564 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1006543004565 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1006543004566 RNA binding surface [nucleotide binding]; other site 1006543004567 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1006543004568 active site 1006543004569 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1006543004570 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1006543004571 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1006543004572 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1006543004573 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1006543004574 active site 1006543004575 Int/Topo IB signature motif; other site 1006543004576 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1006543004577 metal binding site 2 [ion binding]; metal-binding site 1006543004578 putative DNA binding helix; other site 1006543004579 metal binding site 1 [ion binding]; metal-binding site 1006543004580 dimer interface [polypeptide binding]; other site 1006543004581 structural Zn2+ binding site [ion binding]; other site 1006543004582 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1006543004583 dimer interface [polypeptide binding]; other site 1006543004584 ADP-ribose binding site [chemical binding]; other site 1006543004585 active site 1006543004586 nudix motif; other site 1006543004587 metal binding site [ion binding]; metal-binding site 1006543004588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1006543004589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1006543004590 active site 1006543004591 catalytic tetrad [active] 1006543004592 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1006543004593 classical (c) SDRs; Region: SDR_c; cd05233 1006543004594 NAD(P) binding site [chemical binding]; other site 1006543004595 active site 1006543004596 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1006543004597 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1006543004598 ribonuclease Z; Region: RNase_Z; TIGR02651 1006543004599 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1006543004600 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1006543004601 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1006543004602 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1006543004603 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1006543004604 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1006543004605 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1006543004606 Ca binding site [ion binding]; other site 1006543004607 active site 1006543004608 catalytic site [active] 1006543004609 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1006543004610 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1006543004611 DNA binding site [nucleotide binding] 1006543004612 domain linker motif; other site 1006543004613 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1006543004614 putative ligand binding site [chemical binding]; other site 1006543004615 putative dimerization interface [polypeptide binding]; other site 1006543004616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1006543004617 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1006543004618 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1006543004619 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1006543004620 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1006543004621 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1006543004622 peptidase T-like protein; Region: PepT-like; TIGR01883 1006543004623 metal binding site [ion binding]; metal-binding site 1006543004624 putative dimer interface [polypeptide binding]; other site 1006543004625 Predicted membrane protein [Function unknown]; Region: COG4129 1006543004626 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1006543004627 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1006543004628 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1006543004629 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1006543004630 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1006543004631 E3 interaction surface; other site 1006543004632 lipoyl attachment site [posttranslational modification]; other site 1006543004633 e3 binding domain; Region: E3_binding; pfam02817 1006543004634 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1006543004635 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1006543004636 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1006543004637 alpha subunit interface [polypeptide binding]; other site 1006543004638 TPP binding site [chemical binding]; other site 1006543004639 heterodimer interface [polypeptide binding]; other site 1006543004640 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1006543004641 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1006543004642 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1006543004643 tetramer interface [polypeptide binding]; other site 1006543004644 TPP-binding site [chemical binding]; other site 1006543004645 heterodimer interface [polypeptide binding]; other site 1006543004646 phosphorylation loop region [posttranslational modification] 1006543004647 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1006543004648 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1006543004649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543004650 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1006543004651 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1006543004652 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1006543004653 Walker A/P-loop; other site 1006543004654 ATP binding site [chemical binding]; other site 1006543004655 Q-loop/lid; other site 1006543004656 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1006543004657 ABC transporter signature motif; other site 1006543004658 Walker B; other site 1006543004659 D-loop; other site 1006543004660 H-loop/switch region; other site 1006543004661 arginine repressor; Provisional; Region: PRK04280 1006543004662 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1006543004663 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1006543004664 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1006543004665 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1006543004666 substrate binding pocket [chemical binding]; other site 1006543004667 chain length determination region; other site 1006543004668 substrate-Mg2+ binding site; other site 1006543004669 catalytic residues [active] 1006543004670 aspartate-rich region 1; other site 1006543004671 active site lid residues [active] 1006543004672 aspartate-rich region 2; other site 1006543004673 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1006543004674 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1006543004675 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1006543004676 generic binding surface II; other site 1006543004677 generic binding surface I; other site 1006543004678 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1006543004679 putative RNA binding site [nucleotide binding]; other site 1006543004680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1006543004681 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1006543004682 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1006543004683 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1006543004684 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1006543004685 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1006543004686 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1006543004687 carboxyltransferase (CT) interaction site; other site 1006543004688 biotinylation site [posttranslational modification]; other site 1006543004689 elongation factor P; Validated; Region: PRK00529 1006543004690 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1006543004691 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1006543004692 RNA binding site [nucleotide binding]; other site 1006543004693 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1006543004694 RNA binding site [nucleotide binding]; other site 1006543004695 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1006543004696 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1006543004697 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1006543004698 active site 1006543004699 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1006543004700 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1006543004701 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1006543004702 active site residue [active] 1006543004703 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1006543004704 tetramer interface [polypeptide binding]; other site 1006543004705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543004706 catalytic residue [active] 1006543004707 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1006543004708 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1006543004709 tetramer interface [polypeptide binding]; other site 1006543004710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543004711 catalytic residue [active] 1006543004712 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1006543004713 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1006543004714 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1006543004715 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1006543004716 ADP binding site [chemical binding]; other site 1006543004717 magnesium binding site [ion binding]; other site 1006543004718 putative shikimate binding site; other site 1006543004719 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1006543004720 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1006543004721 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1006543004722 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1006543004723 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1006543004724 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1006543004725 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1006543004726 Type II/IV secretion system protein; Region: T2SE; pfam00437 1006543004727 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1006543004728 Walker A motif; other site 1006543004729 ATP binding site [chemical binding]; other site 1006543004730 Walker B motif; other site 1006543004731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1006543004732 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1006543004733 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1006543004734 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1006543004735 Rhomboid family; Region: Rhomboid; pfam01694 1006543004736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1006543004737 binding surface 1006543004738 TPR motif; other site 1006543004739 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1006543004740 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1006543004741 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1006543004742 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1006543004743 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1006543004744 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1006543004745 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1006543004746 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1006543004747 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1006543004748 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1006543004749 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1006543004750 metal binding site 2 [ion binding]; metal-binding site 1006543004751 putative DNA binding helix; other site 1006543004752 metal binding site 1 [ion binding]; metal-binding site 1006543004753 dimer interface [polypeptide binding]; other site 1006543004754 structural Zn2+ binding site [ion binding]; other site 1006543004755 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1006543004756 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543004757 ABC-ATPase subunit interface; other site 1006543004758 dimer interface [polypeptide binding]; other site 1006543004759 putative PBP binding regions; other site 1006543004760 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1006543004761 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1006543004762 endonuclease IV; Provisional; Region: PRK01060 1006543004763 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1006543004764 AP (apurinic/apyrimidinic) site pocket; other site 1006543004765 DNA interaction; other site 1006543004766 Metal-binding active site; metal-binding site 1006543004767 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1006543004768 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1006543004769 ATP binding site [chemical binding]; other site 1006543004770 Mg++ binding site [ion binding]; other site 1006543004771 motif III; other site 1006543004772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1006543004773 nucleotide binding region [chemical binding]; other site 1006543004774 ATP-binding site [chemical binding]; other site 1006543004775 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1006543004776 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1006543004777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1006543004778 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1006543004779 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1006543004780 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1006543004781 Family of unknown function (DUF633); Region: DUF633; pfam04816 1006543004782 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1006543004783 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1006543004784 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1006543004785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1006543004786 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1006543004787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1006543004788 DNA binding residues [nucleotide binding] 1006543004789 DNA primase, catalytic core; Region: dnaG; TIGR01391 1006543004790 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1006543004791 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1006543004792 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1006543004793 active site 1006543004794 metal binding site [ion binding]; metal-binding site 1006543004795 interdomain interaction site; other site 1006543004796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1006543004797 HTH domain; Region: HTH_11; cl17392 1006543004798 FOG: CBS domain [General function prediction only]; Region: COG0517 1006543004799 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1006543004800 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1006543004801 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1006543004802 motif 1; other site 1006543004803 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1006543004804 active site 1006543004805 motif 2; other site 1006543004806 motif 3; other site 1006543004807 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1006543004808 anticodon binding site; other site 1006543004809 DNA repair protein RecO; Region: reco; TIGR00613 1006543004810 Recombination protein O N terminal; Region: RecO_N; pfam11967 1006543004811 Recombination protein O C terminal; Region: RecO_C; pfam02565 1006543004812 GTPase Era; Reviewed; Region: era; PRK00089 1006543004813 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1006543004814 G1 box; other site 1006543004815 GTP/Mg2+ binding site [chemical binding]; other site 1006543004816 Switch I region; other site 1006543004817 G2 box; other site 1006543004818 Switch II region; other site 1006543004819 G3 box; other site 1006543004820 G4 box; other site 1006543004821 G5 box; other site 1006543004822 KH domain; Region: KH_2; pfam07650 1006543004823 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1006543004824 active site 1006543004825 catalytic motif [active] 1006543004826 Zn binding site [ion binding]; other site 1006543004827 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1006543004828 metal-binding heat shock protein; Provisional; Region: PRK00016 1006543004829 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1006543004830 PhoH-like protein; Region: PhoH; pfam02562 1006543004831 hypothetical protein; Provisional; Region: PRK13665 1006543004832 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1006543004833 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1006543004834 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1006543004835 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1006543004836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543004837 FeS/SAM binding site; other site 1006543004838 TRAM domain; Region: TRAM; cl01282 1006543004839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1006543004840 RNA methyltransferase, RsmE family; Region: TIGR00046 1006543004841 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1006543004842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543004843 S-adenosylmethionine binding site [chemical binding]; other site 1006543004844 chaperone protein DnaJ; Provisional; Region: PRK14280 1006543004845 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1006543004846 HSP70 interaction site [polypeptide binding]; other site 1006543004847 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1006543004848 substrate binding site [polypeptide binding]; other site 1006543004849 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1006543004850 Zn binding sites [ion binding]; other site 1006543004851 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1006543004852 dimer interface [polypeptide binding]; other site 1006543004853 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1006543004854 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1006543004855 nucleotide binding site [chemical binding]; other site 1006543004856 NEF interaction site [polypeptide binding]; other site 1006543004857 SBD interface [polypeptide binding]; other site 1006543004858 heat shock protein GrpE; Provisional; Region: PRK14140 1006543004859 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1006543004860 dimer interface [polypeptide binding]; other site 1006543004861 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1006543004862 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1006543004863 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1006543004864 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 1006543004865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543004866 FeS/SAM binding site; other site 1006543004867 HemN C-terminal domain; Region: HemN_C; pfam06969 1006543004868 GTP-binding protein LepA; Provisional; Region: PRK05433 1006543004869 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1006543004870 G1 box; other site 1006543004871 putative GEF interaction site [polypeptide binding]; other site 1006543004872 GTP/Mg2+ binding site [chemical binding]; other site 1006543004873 Switch I region; other site 1006543004874 G2 box; other site 1006543004875 G3 box; other site 1006543004876 Switch II region; other site 1006543004877 G4 box; other site 1006543004878 G5 box; other site 1006543004879 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1006543004880 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1006543004881 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1006543004882 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1006543004883 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1006543004884 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1006543004885 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1006543004886 Competence protein; Region: Competence; pfam03772 1006543004887 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1006543004888 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1006543004889 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1006543004890 catalytic motif [active] 1006543004891 Zn binding site [ion binding]; other site 1006543004892 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1006543004893 SLBB domain; Region: SLBB; pfam10531 1006543004894 Helix-hairpin-helix motif; Region: HHH; pfam00633 1006543004895 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1006543004896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543004897 S-adenosylmethionine binding site [chemical binding]; other site 1006543004898 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1006543004899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1006543004900 Zn2+ binding site [ion binding]; other site 1006543004901 Mg2+ binding site [ion binding]; other site 1006543004902 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1006543004903 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1006543004904 active site 1006543004905 (T/H)XGH motif; other site 1006543004906 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1006543004907 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1006543004908 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1006543004909 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1006543004910 shikimate binding site; other site 1006543004911 NAD(P) binding site [chemical binding]; other site 1006543004912 GTPase YqeH; Provisional; Region: PRK13796 1006543004913 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1006543004914 GTP/Mg2+ binding site [chemical binding]; other site 1006543004915 G4 box; other site 1006543004916 G5 box; other site 1006543004917 G1 box; other site 1006543004918 Switch I region; other site 1006543004919 G2 box; other site 1006543004920 G3 box; other site 1006543004921 Switch II region; other site 1006543004922 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1006543004923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543004924 active site 1006543004925 motif I; other site 1006543004926 motif II; other site 1006543004927 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1006543004928 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1006543004929 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1006543004930 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543004931 Fic family protein [Function unknown]; Region: COG3177 1006543004932 Fic/DOC family; Region: Fic; pfam02661 1006543004933 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1006543004934 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1006543004935 putative active site [active] 1006543004936 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1006543004937 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1006543004938 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1006543004939 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1006543004940 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1006543004941 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1006543004942 carboxyltransferase (CT) interaction site; other site 1006543004943 biotinylation site [posttranslational modification]; other site 1006543004944 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1006543004945 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1006543004946 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1006543004947 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1006543004948 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1006543004949 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1006543004950 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1006543004951 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1006543004952 Sugar specificity; other site 1006543004953 Pyrimidine base specificity; other site 1006543004954 ATP-binding site [chemical binding]; other site 1006543004955 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1006543004956 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1006543004957 Peptidase family U32; Region: Peptidase_U32; pfam01136 1006543004958 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1006543004959 Peptidase family U32; Region: Peptidase_U32; pfam01136 1006543004960 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1006543004961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543004962 S-adenosylmethionine binding site [chemical binding]; other site 1006543004963 hypothetical protein; Provisional; Region: PRK13678 1006543004964 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1006543004965 hypothetical protein; Provisional; Region: PRK05473 1006543004966 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1006543004967 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1006543004968 motif 1; other site 1006543004969 active site 1006543004970 motif 2; other site 1006543004971 motif 3; other site 1006543004972 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1006543004973 DHHA1 domain; Region: DHHA1; pfam02272 1006543004974 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1006543004975 AAA domain; Region: AAA_30; pfam13604 1006543004976 Family description; Region: UvrD_C_2; pfam13538 1006543004977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1006543004978 binding surface 1006543004979 TPR motif; other site 1006543004980 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1006543004981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1006543004982 binding surface 1006543004983 TPR motif; other site 1006543004984 TPR repeat; Region: TPR_11; pfam13414 1006543004985 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1006543004986 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1006543004987 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1006543004988 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1006543004989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1006543004990 catalytic residue [active] 1006543004991 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1006543004992 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1006543004993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1006543004994 Predicted transcriptional regulator [Transcription]; Region: COG1959 1006543004995 Transcriptional regulator; Region: Rrf2; pfam02082 1006543004996 recombination factor protein RarA; Reviewed; Region: PRK13342 1006543004997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543004998 Walker A motif; other site 1006543004999 ATP binding site [chemical binding]; other site 1006543005000 Walker B motif; other site 1006543005001 arginine finger; other site 1006543005002 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1006543005003 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1006543005004 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1006543005005 putative ATP binding site [chemical binding]; other site 1006543005006 putative substrate interface [chemical binding]; other site 1006543005007 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1006543005008 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1006543005009 dimer interface [polypeptide binding]; other site 1006543005010 anticodon binding site; other site 1006543005011 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1006543005012 homodimer interface [polypeptide binding]; other site 1006543005013 motif 1; other site 1006543005014 active site 1006543005015 motif 2; other site 1006543005016 GAD domain; Region: GAD; pfam02938 1006543005017 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1006543005018 motif 3; other site 1006543005019 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1006543005020 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1006543005021 dimer interface [polypeptide binding]; other site 1006543005022 motif 1; other site 1006543005023 active site 1006543005024 motif 2; other site 1006543005025 motif 3; other site 1006543005026 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1006543005027 anticodon binding site; other site 1006543005028 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1006543005029 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1006543005030 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1006543005031 active site 1006543005032 metal binding site [ion binding]; metal-binding site 1006543005033 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1006543005034 putative active site [active] 1006543005035 dimerization interface [polypeptide binding]; other site 1006543005036 putative tRNAtyr binding site [nucleotide binding]; other site 1006543005037 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1006543005038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1006543005039 Zn2+ binding site [ion binding]; other site 1006543005040 Mg2+ binding site [ion binding]; other site 1006543005041 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1006543005042 synthetase active site [active] 1006543005043 NTP binding site [chemical binding]; other site 1006543005044 metal binding site [ion binding]; metal-binding site 1006543005045 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1006543005046 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1006543005047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1006543005048 active site 1006543005049 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1006543005050 DHH family; Region: DHH; pfam01368 1006543005051 DHHA1 domain; Region: DHHA1; pfam02272 1006543005052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1006543005053 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1006543005054 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1006543005055 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1006543005056 Protein export membrane protein; Region: SecD_SecF; pfam02355 1006543005057 Preprotein translocase subunit; Region: YajC; pfam02699 1006543005058 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1006543005059 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1006543005060 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1006543005061 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1006543005062 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1006543005063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543005064 Walker A motif; other site 1006543005065 ATP binding site [chemical binding]; other site 1006543005066 Walker B motif; other site 1006543005067 arginine finger; other site 1006543005068 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1006543005069 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1006543005070 RuvA N terminal domain; Region: RuvA_N; pfam01330 1006543005071 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1006543005072 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 1006543005073 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1006543005074 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1006543005075 GTP1/OBG; Region: GTP1_OBG; pfam01018 1006543005076 Obg GTPase; Region: Obg; cd01898 1006543005077 G1 box; other site 1006543005078 GTP/Mg2+ binding site [chemical binding]; other site 1006543005079 Switch I region; other site 1006543005080 G2 box; other site 1006543005081 G3 box; other site 1006543005082 Switch II region; other site 1006543005083 G4 box; other site 1006543005084 G5 box; other site 1006543005085 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1006543005086 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1006543005087 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1006543005088 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1006543005089 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1006543005090 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1006543005091 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1006543005092 rod shape-determining protein MreC; Region: MreC; pfam04085 1006543005093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543005094 S-adenosylmethionine binding site [chemical binding]; other site 1006543005095 Erm Leader peptide; Region: Leader_Erm; pfam08253 1006543005096 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1006543005097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543005098 S-adenosylmethionine binding site [chemical binding]; other site 1006543005099 aminoglycoside resistance protein; Provisional; Region: PRK13746 1006543005100 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1006543005101 active site 1006543005102 NTP binding site [chemical binding]; other site 1006543005103 metal binding triad [ion binding]; metal-binding site 1006543005104 antibiotic binding site [chemical binding]; other site 1006543005105 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1006543005106 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1006543005107 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1006543005108 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 1006543005109 Int/Topo IB signature motif; other site 1006543005110 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1006543005111 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1006543005112 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 1006543005113 Int/Topo IB signature motif; other site 1006543005114 hypothetical protein; Reviewed; Region: PRK00024 1006543005115 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1006543005116 MPN+ (JAMM) motif; other site 1006543005117 Zinc-binding site [ion binding]; other site 1006543005118 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1006543005119 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1006543005120 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1006543005121 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1006543005122 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1006543005123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1006543005124 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1006543005125 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1006543005126 active site 1006543005127 HIGH motif; other site 1006543005128 nucleotide binding site [chemical binding]; other site 1006543005129 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1006543005130 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1006543005131 active site 1006543005132 KMSKS motif; other site 1006543005133 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1006543005134 tRNA binding surface [nucleotide binding]; other site 1006543005135 anticodon binding site; other site 1006543005136 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1006543005137 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1006543005138 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1006543005139 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1006543005140 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1006543005141 inhibitor-cofactor binding pocket; inhibition site 1006543005142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543005143 catalytic residue [active] 1006543005144 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1006543005145 dimer interface [polypeptide binding]; other site 1006543005146 active site 1006543005147 Schiff base residues; other site 1006543005148 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1006543005149 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1006543005150 active site 1006543005151 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1006543005152 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1006543005153 domain interfaces; other site 1006543005154 active site 1006543005155 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 1006543005156 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1006543005157 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1006543005158 tRNA; other site 1006543005159 putative tRNA binding site [nucleotide binding]; other site 1006543005160 putative NADP binding site [chemical binding]; other site 1006543005161 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1006543005162 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1006543005163 G1 box; other site 1006543005164 GTP/Mg2+ binding site [chemical binding]; other site 1006543005165 Switch I region; other site 1006543005166 G2 box; other site 1006543005167 G3 box; other site 1006543005168 Switch II region; other site 1006543005169 G4 box; other site 1006543005170 G5 box; other site 1006543005171 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1006543005172 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1006543005173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543005174 Walker A motif; other site 1006543005175 ATP binding site [chemical binding]; other site 1006543005176 Walker B motif; other site 1006543005177 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1006543005178 trigger factor; Provisional; Region: tig; PRK01490 1006543005179 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1006543005180 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1006543005181 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1006543005182 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1006543005183 23S rRNA binding site [nucleotide binding]; other site 1006543005184 L21 binding site [polypeptide binding]; other site 1006543005185 L13 binding site [polypeptide binding]; other site 1006543005186 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1006543005187 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1006543005188 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1006543005189 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1006543005190 lysine transporter; Provisional; Region: PRK10836 1006543005191 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1006543005192 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1006543005193 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1006543005194 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1006543005195 active site 1006543005196 dimer interface [polypeptide binding]; other site 1006543005197 motif 1; other site 1006543005198 motif 2; other site 1006543005199 motif 3; other site 1006543005200 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1006543005201 anticodon binding site; other site 1006543005202 primosomal protein DnaI; Reviewed; Region: PRK08939 1006543005203 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1006543005204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543005205 Walker A motif; other site 1006543005206 ATP binding site [chemical binding]; other site 1006543005207 Walker B motif; other site 1006543005208 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1006543005209 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1006543005210 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1006543005211 ATP cone domain; Region: ATP-cone; pfam03477 1006543005212 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1006543005213 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1006543005214 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1006543005215 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1006543005216 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1006543005217 CoA-binding site [chemical binding]; other site 1006543005218 ATP-binding [chemical binding]; other site 1006543005219 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1006543005220 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1006543005221 DNA binding site [nucleotide binding] 1006543005222 catalytic residue [active] 1006543005223 H2TH interface [polypeptide binding]; other site 1006543005224 putative catalytic residues [active] 1006543005225 turnover-facilitating residue; other site 1006543005226 intercalation triad [nucleotide binding]; other site 1006543005227 8OG recognition residue [nucleotide binding]; other site 1006543005228 putative reading head residues; other site 1006543005229 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1006543005230 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1006543005231 DNA polymerase I; Provisional; Region: PRK05755 1006543005232 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1006543005233 active site 1006543005234 metal binding site 1 [ion binding]; metal-binding site 1006543005235 putative 5' ssDNA interaction site; other site 1006543005236 metal binding site 3; metal-binding site 1006543005237 metal binding site 2 [ion binding]; metal-binding site 1006543005238 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1006543005239 putative DNA binding site [nucleotide binding]; other site 1006543005240 putative metal binding site [ion binding]; other site 1006543005241 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1006543005242 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1006543005243 active site 1006543005244 DNA binding site [nucleotide binding] 1006543005245 catalytic site [active] 1006543005246 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1006543005247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1006543005248 dimer interface [polypeptide binding]; other site 1006543005249 phosphorylation site [posttranslational modification] 1006543005250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543005251 ATP binding site [chemical binding]; other site 1006543005252 Mg2+ binding site [ion binding]; other site 1006543005253 G-X-G motif; other site 1006543005254 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1006543005255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543005256 active site 1006543005257 phosphorylation site [posttranslational modification] 1006543005258 intermolecular recognition site; other site 1006543005259 dimerization interface [polypeptide binding]; other site 1006543005260 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1006543005261 DNA binding site [nucleotide binding] 1006543005262 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1006543005263 isocitrate dehydrogenase; Validated; Region: PRK07362 1006543005264 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1006543005265 dimer interface [polypeptide binding]; other site 1006543005266 Citrate synthase; Region: Citrate_synt; pfam00285 1006543005267 active site 1006543005268 citrylCoA binding site [chemical binding]; other site 1006543005269 oxalacetate/citrate binding site [chemical binding]; other site 1006543005270 coenzyme A binding site [chemical binding]; other site 1006543005271 catalytic triad [active] 1006543005272 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1006543005273 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1006543005274 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1006543005275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1006543005276 pyruvate kinase; Provisional; Region: PRK06354 1006543005277 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1006543005278 domain interfaces; other site 1006543005279 active site 1006543005280 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1006543005281 6-phosphofructokinase; Provisional; Region: PRK03202 1006543005282 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1006543005283 active site 1006543005284 ADP/pyrophosphate binding site [chemical binding]; other site 1006543005285 dimerization interface [polypeptide binding]; other site 1006543005286 allosteric effector site; other site 1006543005287 fructose-1,6-bisphosphate binding site; other site 1006543005288 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1006543005289 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1006543005290 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1006543005291 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1006543005292 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1006543005293 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1006543005294 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1006543005295 putative NAD(P) binding site [chemical binding]; other site 1006543005296 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1006543005297 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1006543005298 active site 1006543005299 PHP Thumb interface [polypeptide binding]; other site 1006543005300 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1006543005301 generic binding surface I; other site 1006543005302 generic binding surface II; other site 1006543005303 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1006543005304 DHH family; Region: DHH; pfam01368 1006543005305 DHHA1 domain; Region: DHHA1; pfam02272 1006543005306 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1006543005307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1006543005308 DNA-binding site [nucleotide binding]; DNA binding site 1006543005309 DRTGG domain; Region: DRTGG; pfam07085 1006543005310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1006543005311 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1006543005312 active site 2 [active] 1006543005313 active site 1 [active] 1006543005314 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1006543005315 Ligand Binding Site [chemical binding]; other site 1006543005316 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1006543005317 metal-dependent hydrolase; Provisional; Region: PRK00685 1006543005318 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1006543005319 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1006543005320 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1006543005321 active site 1006543005322 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1006543005323 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1006543005324 hexamer interface [polypeptide binding]; other site 1006543005325 ligand binding site [chemical binding]; other site 1006543005326 putative active site [active] 1006543005327 NAD(P) binding site [chemical binding]; other site 1006543005328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1006543005329 Ligand Binding Site [chemical binding]; other site 1006543005330 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1006543005331 propionate/acetate kinase; Provisional; Region: PRK12379 1006543005332 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1006543005333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543005334 S-adenosylmethionine binding site [chemical binding]; other site 1006543005335 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1006543005336 dimer interface [polypeptide binding]; other site 1006543005337 catalytic triad [active] 1006543005338 peroxidatic and resolving cysteines [active] 1006543005339 hypothetical protein; Provisional; Region: PRK10621 1006543005340 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1006543005341 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1006543005342 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1006543005343 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1006543005344 Ligand Binding Site [chemical binding]; other site 1006543005345 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1006543005346 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1006543005347 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1006543005348 catalytic residue [active] 1006543005349 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1006543005350 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1006543005351 GAF domain; Region: GAF_2; pfam13185 1006543005352 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1006543005353 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1006543005354 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1006543005355 RNA binding surface [nucleotide binding]; other site 1006543005356 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1006543005357 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1006543005358 active site 1006543005359 catalytic site [active] 1006543005360 OsmC-like protein; Region: OsmC; cl00767 1006543005361 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1006543005362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1006543005363 catalytic residue [active] 1006543005364 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1006543005365 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1006543005366 ligand binding site [chemical binding]; other site 1006543005367 NAD binding site [chemical binding]; other site 1006543005368 dimerization interface [polypeptide binding]; other site 1006543005369 catalytic site [active] 1006543005370 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1006543005371 putative L-serine binding site [chemical binding]; other site 1006543005372 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1006543005373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543005374 motif II; other site 1006543005375 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1006543005376 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1006543005377 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1006543005378 active site turn [active] 1006543005379 phosphorylation site [posttranslational modification] 1006543005380 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1006543005381 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1006543005382 putative acyl-acceptor binding pocket; other site 1006543005383 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1006543005384 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1006543005385 protein binding site [polypeptide binding]; other site 1006543005386 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1006543005387 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1006543005388 active site 1006543005389 HIGH motif; other site 1006543005390 dimer interface [polypeptide binding]; other site 1006543005391 KMSKS motif; other site 1006543005392 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1006543005393 RNA binding surface [nucleotide binding]; other site 1006543005394 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1006543005395 Transglycosylase; Region: Transgly; pfam00912 1006543005396 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1006543005397 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1006543005398 NEAr Transporter domain; Region: NEAT; smart00725 1006543005399 NEAr Transporter domain; Region: NEAT; smart00725 1006543005400 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1006543005401 heme-binding site [chemical binding]; other site 1006543005402 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1006543005403 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1006543005404 Potassium binding sites [ion binding]; other site 1006543005405 Cesium cation binding sites [ion binding]; other site 1006543005406 acetyl-CoA synthetase; Provisional; Region: PRK04319 1006543005407 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1006543005408 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1006543005409 active site 1006543005410 acyl-activating enzyme (AAE) consensus motif; other site 1006543005411 putative CoA binding site [chemical binding]; other site 1006543005412 AMP binding site [chemical binding]; other site 1006543005413 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1006543005414 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1006543005415 active site 1006543005416 Zn binding site [ion binding]; other site 1006543005417 catabolite control protein A; Region: ccpA; TIGR01481 1006543005418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1006543005419 DNA binding site [nucleotide binding] 1006543005420 domain linker motif; other site 1006543005421 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1006543005422 dimerization interface [polypeptide binding]; other site 1006543005423 effector binding site; other site 1006543005424 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1006543005425 Chorismate mutase type II; Region: CM_2; cl00693 1006543005426 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1006543005427 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1006543005428 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1006543005429 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1006543005430 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1006543005431 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1006543005432 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1006543005433 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1006543005434 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1006543005435 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1006543005436 putative tRNA-binding site [nucleotide binding]; other site 1006543005437 hypothetical protein; Provisional; Region: PRK13668 1006543005438 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1006543005439 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1006543005440 catalytic residues [active] 1006543005441 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1006543005442 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1006543005443 oligomer interface [polypeptide binding]; other site 1006543005444 active site 1006543005445 metal binding site [ion binding]; metal-binding site 1006543005446 Predicted small secreted protein [Function unknown]; Region: COG5584 1006543005447 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1006543005448 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1006543005449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543005450 S-adenosylmethionine binding site [chemical binding]; other site 1006543005451 Phosphotransferase enzyme family; Region: APH; pfam01636 1006543005452 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1006543005453 active site 1006543005454 substrate binding site [chemical binding]; other site 1006543005455 ATP binding site [chemical binding]; other site 1006543005456 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1006543005457 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1006543005458 homodimer interface [polypeptide binding]; other site 1006543005459 substrate-cofactor binding pocket; other site 1006543005460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543005461 catalytic residue [active] 1006543005462 dipeptidase PepV; Reviewed; Region: PRK07318 1006543005463 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1006543005464 active site 1006543005465 metal binding site [ion binding]; metal-binding site 1006543005466 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1006543005467 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1006543005468 RNA binding surface [nucleotide binding]; other site 1006543005469 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1006543005470 active site 1006543005471 uracil binding [chemical binding]; other site 1006543005472 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1006543005473 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1006543005474 HI0933-like protein; Region: HI0933_like; pfam03486 1006543005475 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543005476 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1006543005477 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005478 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005479 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005480 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005481 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005482 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005483 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005484 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005485 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005486 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005487 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005488 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005489 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005490 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005491 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543005492 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1006543005493 active site residue [active] 1006543005494 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1006543005495 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1006543005496 HIGH motif; other site 1006543005497 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1006543005498 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1006543005499 active site 1006543005500 KMSKS motif; other site 1006543005501 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1006543005502 tRNA binding surface [nucleotide binding]; other site 1006543005503 potential frameshift: common BLAST hit: gi|87160224|ref|YP_494399.1| putative drug transporter 1006543005504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543005505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543005506 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1006543005507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543005508 S-adenosylmethionine binding site [chemical binding]; other site 1006543005509 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543005510 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543005511 MULE transposase domain; Region: MULE; pfam10551 1006543005512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1006543005513 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1006543005514 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1006543005515 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1006543005516 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1006543005517 homopentamer interface [polypeptide binding]; other site 1006543005518 active site 1006543005519 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1006543005520 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1006543005521 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1006543005522 dimerization interface [polypeptide binding]; other site 1006543005523 active site 1006543005524 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1006543005525 Lumazine binding domain; Region: Lum_binding; pfam00677 1006543005526 Lumazine binding domain; Region: Lum_binding; pfam00677 1006543005527 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1006543005528 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1006543005529 catalytic motif [active] 1006543005530 Zn binding site [ion binding]; other site 1006543005531 RibD C-terminal domain; Region: RibD_C; cl17279 1006543005532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1006543005533 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1006543005534 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1006543005535 arsenical pump membrane protein; Provisional; Region: PRK15445 1006543005536 transmembrane helices; other site 1006543005537 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1006543005538 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1006543005539 active site 1006543005540 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1006543005541 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1006543005542 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1006543005543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1006543005544 DNA binding residues [nucleotide binding] 1006543005545 CAAX protease self-immunity; Region: Abi; pfam02517 1006543005546 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1006543005547 active site 1006543005548 intersubunit interactions; other site 1006543005549 catalytic residue [active] 1006543005550 camphor resistance protein CrcB; Provisional; Region: PRK14201 1006543005551 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1006543005552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1006543005553 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1006543005554 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1006543005555 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1006543005556 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1006543005557 active site 1006543005558 catalytic tetrad [active] 1006543005559 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1006543005560 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1006543005561 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1006543005562 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1006543005563 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1006543005564 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1006543005565 active site 1006543005566 substrate-binding site [chemical binding]; other site 1006543005567 metal-binding site [ion binding] 1006543005568 ATP binding site [chemical binding]; other site 1006543005569 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1006543005570 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1006543005571 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1006543005572 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1006543005573 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1006543005574 nudix motif; other site 1006543005575 Haemolytic domain; Region: Haemolytic; pfam01809 1006543005576 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1006543005577 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1006543005578 metal binding site [ion binding]; metal-binding site 1006543005579 substrate binding pocket [chemical binding]; other site 1006543005580 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1006543005581 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1006543005582 acyl-activating enzyme (AAE) consensus motif; other site 1006543005583 putative AMP binding site [chemical binding]; other site 1006543005584 putative active site [active] 1006543005585 putative CoA binding site [chemical binding]; other site 1006543005586 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1006543005587 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1006543005588 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1006543005589 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1006543005590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1006543005591 Transposase; Region: HTH_Tnp_1; cl17663 1006543005592 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1006543005593 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1006543005594 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1006543005595 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1006543005596 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1006543005597 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1006543005598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543005599 S-adenosylmethionine binding site [chemical binding]; other site 1006543005600 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1006543005601 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1006543005602 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1006543005603 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1006543005604 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1006543005605 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1006543005606 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1006543005607 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1006543005608 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1006543005609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543005610 Walker A/P-loop; other site 1006543005611 ATP binding site [chemical binding]; other site 1006543005612 Q-loop/lid; other site 1006543005613 ABC transporter signature motif; other site 1006543005614 Walker B; other site 1006543005615 D-loop; other site 1006543005616 H-loop/switch region; other site 1006543005617 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 1006543005618 active site 1006543005619 catalytic triad [active] 1006543005620 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1006543005621 Flavoprotein; Region: Flavoprotein; pfam02441 1006543005622 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1006543005623 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 1006543005624 active site 1006543005625 zinc binding site [ion binding]; other site 1006543005626 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1006543005627 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1006543005628 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1006543005629 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 1006543005630 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1006543005631 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1006543005632 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1006543005633 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 1006543005634 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1006543005635 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1006543005636 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1006543005637 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1006543005638 ferrochelatase; Provisional; Region: PRK12435 1006543005639 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1006543005640 C-terminal domain interface [polypeptide binding]; other site 1006543005641 active site 1006543005642 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1006543005643 active site 1006543005644 N-terminal domain interface [polypeptide binding]; other site 1006543005645 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1006543005646 substrate binding site [chemical binding]; other site 1006543005647 active site 1006543005648 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1006543005649 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1006543005650 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1006543005651 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1006543005652 Walker A/P-loop; other site 1006543005653 ATP binding site [chemical binding]; other site 1006543005654 Q-loop/lid; other site 1006543005655 ABC transporter signature motif; other site 1006543005656 Walker B; other site 1006543005657 D-loop; other site 1006543005658 H-loop/switch region; other site 1006543005659 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1006543005660 HIT family signature motif; other site 1006543005661 catalytic residue [active] 1006543005662 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1006543005663 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1006543005664 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1006543005665 SurA N-terminal domain; Region: SurA_N_3; cl07813 1006543005666 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1006543005667 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1006543005668 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1006543005669 generic binding surface II; other site 1006543005670 generic binding surface I; other site 1006543005671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1006543005672 Zn2+ binding site [ion binding]; other site 1006543005673 Mg2+ binding site [ion binding]; other site 1006543005674 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1006543005675 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1006543005676 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 1006543005677 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1006543005678 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1006543005679 active site 1006543005680 metal binding site [ion binding]; metal-binding site 1006543005681 DNA binding site [nucleotide binding] 1006543005682 hypothetical protein; Provisional; Region: PRK13676 1006543005683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1006543005684 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1006543005685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543005686 non-specific DNA binding site [nucleotide binding]; other site 1006543005687 salt bridge; other site 1006543005688 sequence-specific DNA binding site [nucleotide binding]; other site 1006543005689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1006543005690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543005691 active site 1006543005692 phosphorylation site [posttranslational modification] 1006543005693 intermolecular recognition site; other site 1006543005694 dimerization interface [polypeptide binding]; other site 1006543005695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1006543005696 DNA binding residues [nucleotide binding] 1006543005697 dimerization interface [polypeptide binding]; other site 1006543005698 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1006543005699 GAF domain; Region: GAF_3; pfam13492 1006543005700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1006543005701 Histidine kinase; Region: HisKA_3; pfam07730 1006543005702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543005703 ATP binding site [chemical binding]; other site 1006543005704 Mg2+ binding site [ion binding]; other site 1006543005705 G-X-G motif; other site 1006543005706 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1006543005707 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1006543005708 active site 1006543005709 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1006543005710 Class II fumarases; Region: Fumarase_classII; cd01362 1006543005711 active site 1006543005712 tetramer interface [polypeptide binding]; other site 1006543005713 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1006543005714 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1006543005715 active site 1006543005716 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1006543005717 epoxyqueuosine reductase; Region: TIGR00276 1006543005718 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1006543005719 HEAT repeats; Region: HEAT_2; pfam13646 1006543005720 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1006543005721 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1006543005722 Walker A/P-loop; other site 1006543005723 ATP binding site [chemical binding]; other site 1006543005724 Q-loop/lid; other site 1006543005725 ABC transporter signature motif; other site 1006543005726 Walker B; other site 1006543005727 D-loop; other site 1006543005728 H-loop/switch region; other site 1006543005729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1006543005730 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1006543005731 substrate binding pocket [chemical binding]; other site 1006543005732 membrane-bound complex binding site; other site 1006543005733 hinge residues; other site 1006543005734 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1006543005735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543005736 dimer interface [polypeptide binding]; other site 1006543005737 conserved gate region; other site 1006543005738 putative PBP binding loops; other site 1006543005739 ABC-ATPase subunit interface; other site 1006543005740 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1006543005741 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1006543005742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1006543005743 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1006543005744 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1006543005745 metal binding site 2 [ion binding]; metal-binding site 1006543005746 putative DNA binding helix; other site 1006543005747 metal binding site 1 [ion binding]; metal-binding site 1006543005748 dimer interface [polypeptide binding]; other site 1006543005749 structural Zn2+ binding site [ion binding]; other site 1006543005750 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1006543005751 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1006543005752 putative ligand binding site [chemical binding]; other site 1006543005753 NAD binding site [chemical binding]; other site 1006543005754 catalytic site [active] 1006543005755 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1006543005756 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1006543005757 catalytic triad [active] 1006543005758 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1006543005759 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1006543005760 inhibitor-cofactor binding pocket; inhibition site 1006543005761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543005762 catalytic residue [active] 1006543005763 Predicted membrane protein [Function unknown]; Region: COG4129 1006543005764 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1006543005765 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1006543005766 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1006543005767 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1006543005768 Walker A/P-loop; other site 1006543005769 ATP binding site [chemical binding]; other site 1006543005770 Q-loop/lid; other site 1006543005771 ABC transporter signature motif; other site 1006543005772 Walker B; other site 1006543005773 D-loop; other site 1006543005774 H-loop/switch region; other site 1006543005775 hypothetical protein; Provisional; Region: PRK13662 1006543005776 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1006543005777 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1006543005778 minor groove reading motif; other site 1006543005779 helix-hairpin-helix signature motif; other site 1006543005780 substrate binding pocket [chemical binding]; other site 1006543005781 active site 1006543005782 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1006543005783 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1006543005784 DNA binding and oxoG recognition site [nucleotide binding] 1006543005785 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1006543005786 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1006543005787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543005788 Walker A/P-loop; other site 1006543005789 ATP binding site [chemical binding]; other site 1006543005790 Q-loop/lid; other site 1006543005791 ABC transporter signature motif; other site 1006543005792 Walker B; other site 1006543005793 H-loop/switch region; other site 1006543005794 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1006543005795 recombination regulator RecX; Provisional; Region: recX; PRK14135 1006543005796 glycosyltransferase; Provisional; Region: PRK13481 1006543005797 Transglycosylase; Region: Transgly; pfam00912 1006543005798 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1006543005799 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1006543005800 proposed catalytic triad [active] 1006543005801 conserved cys residue [active] 1006543005802 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1006543005803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543005804 FeS/SAM binding site; other site 1006543005805 YfkB-like domain; Region: YfkB; pfam08756 1006543005806 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1006543005807 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1006543005808 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1006543005809 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1006543005810 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1006543005811 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1006543005812 active site 1006543005813 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1006543005814 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1006543005815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543005816 active site 1006543005817 phosphorylation site [posttranslational modification] 1006543005818 intermolecular recognition site; other site 1006543005819 dimerization interface [polypeptide binding]; other site 1006543005820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1006543005821 DNA binding residues [nucleotide binding] 1006543005822 dimerization interface [polypeptide binding]; other site 1006543005823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1006543005824 Histidine kinase; Region: HisKA_3; pfam07730 1006543005825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543005826 ATP binding site [chemical binding]; other site 1006543005827 Mg2+ binding site [ion binding]; other site 1006543005828 G-X-G motif; other site 1006543005829 Predicted membrane protein [Function unknown]; Region: COG4758 1006543005830 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1006543005831 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1006543005832 active site 1006543005833 Predicted membrane protein [Function unknown]; Region: COG4129 1006543005834 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1006543005835 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1006543005836 catalytic triad [active] 1006543005837 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1006543005838 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1006543005839 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1006543005840 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1006543005841 Ferritin-like domain; Region: Ferritin; pfam00210 1006543005842 ferroxidase diiron center [ion binding]; other site 1006543005843 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1006543005844 active site 1006543005845 catalytic site [active] 1006543005846 substrate binding site [chemical binding]; other site 1006543005847 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1006543005848 active site 1006543005849 DNA polymerase IV; Validated; Region: PRK02406 1006543005850 DNA binding site [nucleotide binding] 1006543005851 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1006543005852 TRAM domain; Region: TRAM; cl01282 1006543005853 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1006543005854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543005855 S-adenosylmethionine binding site [chemical binding]; other site 1006543005856 putative lipid kinase; Reviewed; Region: PRK13337 1006543005857 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1006543005858 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1006543005859 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1006543005860 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1006543005861 GatB domain; Region: GatB_Yqey; pfam02637 1006543005862 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1006543005863 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1006543005864 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1006543005865 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1006543005866 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1006543005867 Na binding site [ion binding]; other site 1006543005868 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1006543005869 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1006543005870 putative dimer interface [polypeptide binding]; other site 1006543005871 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1006543005872 putative dimer interface [polypeptide binding]; other site 1006543005873 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1006543005874 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1006543005875 nucleotide binding pocket [chemical binding]; other site 1006543005876 K-X-D-G motif; other site 1006543005877 catalytic site [active] 1006543005878 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1006543005879 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1006543005880 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1006543005881 Dimer interface [polypeptide binding]; other site 1006543005882 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1006543005883 Part of AAA domain; Region: AAA_19; pfam13245 1006543005884 Family description; Region: UvrD_C_2; pfam13538 1006543005885 PcrB family; Region: PcrB; pfam01884 1006543005886 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1006543005887 substrate binding site [chemical binding]; other site 1006543005888 putative active site [active] 1006543005889 dimer interface [polypeptide binding]; other site 1006543005890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1006543005891 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1006543005892 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1006543005893 tetramer interface [polypeptide binding]; other site 1006543005894 active site 1006543005895 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1006543005896 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1006543005897 Staphostatin A; Region: Staphostatin_A; pfam09022 1006543005898 NETI protein; Region: NETI; pfam14044 1006543005899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1006543005900 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1006543005901 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1006543005902 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1006543005903 homodimer interface [polypeptide binding]; other site 1006543005904 NAD binding pocket [chemical binding]; other site 1006543005905 ATP binding pocket [chemical binding]; other site 1006543005906 Mg binding site [ion binding]; other site 1006543005907 active-site loop [active] 1006543005908 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1006543005909 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1006543005910 active site 1006543005911 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1006543005912 active site 1006543005913 dimer interface [polypeptide binding]; other site 1006543005914 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1006543005915 Prephenate dehydratase; Region: PDT; pfam00800 1006543005916 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1006543005917 putative L-Phe binding site [chemical binding]; other site 1006543005918 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1006543005919 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1006543005920 transmembrane helices; other site 1006543005921 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1006543005922 Isochorismatase family; Region: Isochorismatase; pfam00857 1006543005923 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1006543005924 catalytic triad [active] 1006543005925 conserved cis-peptide bond; other site 1006543005926 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1006543005927 DHH family; Region: DHH; pfam01368 1006543005928 DHHA2 domain; Region: DHHA2; pfam02833 1006543005929 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1006543005930 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1006543005931 NAD(P) binding site [chemical binding]; other site 1006543005932 catalytic residues [active] 1006543005933 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1006543005934 YolD-like protein; Region: YolD; pfam08863 1006543005935 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1006543005936 active site 1006543005937 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1006543005938 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1006543005939 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1006543005940 Bacterial PH domain; Region: DUF304; cl01348 1006543005941 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 1006543005942 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1006543005943 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1006543005944 Walker A/P-loop; other site 1006543005945 ATP binding site [chemical binding]; other site 1006543005946 Q-loop/lid; other site 1006543005947 ABC transporter signature motif; other site 1006543005948 Walker B; other site 1006543005949 D-loop; other site 1006543005950 H-loop/switch region; other site 1006543005951 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1006543005952 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1006543005953 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1006543005954 Walker A/P-loop; other site 1006543005955 ATP binding site [chemical binding]; other site 1006543005956 Q-loop/lid; other site 1006543005957 ABC transporter signature motif; other site 1006543005958 Walker B; other site 1006543005959 D-loop; other site 1006543005960 H-loop/switch region; other site 1006543005961 Predicted transcriptional regulators [Transcription]; Region: COG1725 1006543005962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1006543005963 DNA-binding site [nucleotide binding]; DNA binding site 1006543005964 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1006543005965 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1006543005966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543005967 homodimer interface [polypeptide binding]; other site 1006543005968 catalytic residue [active] 1006543005969 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543005970 MULE transposase domain; Region: MULE; pfam10551 1006543005971 MAP domain; Region: MAP; pfam03642 1006543005972 MAP domain; Region: MAP; pfam03642 1006543005973 MAP domain; Region: MAP; pfam03642 1006543005974 MAP domain; Region: MAP; pfam03642 1006543005975 MAP domain; Region: MAP; pfam03642 1006543005976 MAP domain; Region: MAP; pfam03642 1006543005977 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1006543005978 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1006543005979 Bacterial SH3 domain; Region: SH3_5; pfam08460 1006543005980 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 1006543005981 CHAP domain; Region: CHAP; pfam05257 1006543005982 Small integral membrane protein [Function unknown]; Region: COG5546 1006543005983 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1006543005984 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1006543005985 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1006543005986 Ligand-gated ion channel; Region: Lig_chan; pfam00060 1006543005987 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 1006543005988 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1006543005989 TolA protein; Region: tolA_full; TIGR02794 1006543005990 Phage tail protein; Region: Sipho_tail; cl17486 1006543005991 Phage tail protein; Region: Sipho_tail; cl17486 1006543005992 Phage-related minor tail protein [Function unknown]; Region: COG5280 1006543005993 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1006543005994 Phage-related protein [Function unknown]; Region: COG5412 1006543005995 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 1006543005996 Peptidase family M23; Region: Peptidase_M23; pfam01551 1006543005997 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1006543005998 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1006543005999 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1006543006000 catalytic residue [active] 1006543006001 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1006543006002 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1006543006003 Translocation protein Sec62; Region: Sec62; cl02170 1006543006004 Phage capsid family; Region: Phage_capsid; pfam05065 1006543006005 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1006543006006 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1006543006007 oligomer interface [polypeptide binding]; other site 1006543006008 active site residues [active] 1006543006009 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1006543006010 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1006543006011 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1006543006012 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1006543006013 HNH endonuclease; Region: HNH; pfam01844 1006543006014 active site 1006543006015 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1006543006016 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1006543006017 Transcriptional activator RinB; Region: RinB; pfam06116 1006543006018 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1006543006019 dUTPase; Region: dUTPase_2; pfam08761 1006543006020 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1006543006021 active site 1006543006022 homodimer interface [polypeptide binding]; other site 1006543006023 metal binding site [ion binding]; metal-binding site 1006543006024 YopX protein; Region: YopX; pfam09643 1006543006025 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1006543006026 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1006543006027 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1006543006028 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1006543006029 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1006543006030 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1006543006031 dimer interface [polypeptide binding]; other site 1006543006032 ssDNA binding site [nucleotide binding]; other site 1006543006033 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1006543006034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1006543006035 RecT family; Region: RecT; pfam03837 1006543006036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543006037 AAA domain; Region: AAA_23; pfam13476 1006543006038 Walker A/P-loop; other site 1006543006039 ATP binding site [chemical binding]; other site 1006543006040 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1006543006041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 1006543006042 Phage anti-repressor protein [Transcription]; Region: COG3561 1006543006043 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1006543006044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543006045 salt bridge; other site 1006543006046 non-specific DNA binding site [nucleotide binding]; other site 1006543006047 sequence-specific DNA binding site [nucleotide binding]; other site 1006543006048 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1006543006049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543006050 non-specific DNA binding site [nucleotide binding]; other site 1006543006051 salt bridge; other site 1006543006052 sequence-specific DNA binding site [nucleotide binding]; other site 1006543006053 Predicted transcriptional regulator [Transcription]; Region: COG2932 1006543006054 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1006543006055 Catalytic site [active] 1006543006056 PemK-like protein; Region: PemK; pfam02452 1006543006057 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1006543006058 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1006543006059 Int/Topo IB signature motif; other site 1006543006060 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1006543006061 putative catalytic site [active] 1006543006062 phosphate binding site [ion binding]; other site 1006543006063 metal binding site A [ion binding]; metal-binding site 1006543006064 metal binding site C [ion binding]; metal-binding site 1006543006065 metal binding site B [ion binding]; metal-binding site 1006543006066 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1006543006067 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1006543006068 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1006543006069 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1006543006070 metal binding site [ion binding]; metal-binding site 1006543006071 dimer interface [polypeptide binding]; other site 1006543006072 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1006543006073 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1006543006074 putative ligand binding residues [chemical binding]; other site 1006543006075 Cation transport protein; Region: TrkH; cl17365 1006543006076 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1006543006077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543006078 Coenzyme A binding pocket [chemical binding]; other site 1006543006079 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1006543006080 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1006543006081 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1006543006082 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1006543006083 gating phenylalanine in ion channel; other site 1006543006084 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1006543006085 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1006543006086 Virulence-associated protein E; Region: VirE; pfam05272 1006543006087 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1006543006088 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 1006543006089 DNA binding domain, excisionase family; Region: excise; TIGR01764 1006543006090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543006091 non-specific DNA binding site [nucleotide binding]; other site 1006543006092 salt bridge; other site 1006543006093 sequence-specific DNA binding site [nucleotide binding]; other site 1006543006094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543006095 non-specific DNA binding site [nucleotide binding]; other site 1006543006096 salt bridge; other site 1006543006097 sequence-specific DNA binding site [nucleotide binding]; other site 1006543006098 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1006543006099 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1006543006100 Int/Topo IB signature motif; other site 1006543006101 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1006543006102 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1006543006103 ring oligomerisation interface [polypeptide binding]; other site 1006543006104 ATP/Mg binding site [chemical binding]; other site 1006543006105 stacking interactions; other site 1006543006106 hinge regions; other site 1006543006107 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1006543006108 oligomerisation interface [polypeptide binding]; other site 1006543006109 mobile loop; other site 1006543006110 roof hairpin; other site 1006543006111 CAAX protease self-immunity; Region: Abi; pfam02517 1006543006112 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1006543006113 dimer interface [polypeptide binding]; other site 1006543006114 FMN binding site [chemical binding]; other site 1006543006115 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1006543006116 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1006543006117 putative active site [active] 1006543006118 catalytic triad [active] 1006543006119 putative dimer interface [polypeptide binding]; other site 1006543006120 delta-hemolysin; Provisional; Region: PRK14752 1006543006121 Accessory gene regulator B; Region: AgrB; smart00793 1006543006122 Staphylococcal AgrD protein; Region: AgrD; smart00794 1006543006123 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543006124 MULE transposase domain; Region: MULE; pfam10551 1006543006125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543006126 Mg2+ binding site [ion binding]; other site 1006543006127 G-X-G motif; other site 1006543006128 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1006543006129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543006130 active site 1006543006131 phosphorylation site [posttranslational modification] 1006543006132 intermolecular recognition site; other site 1006543006133 dimerization interface [polypeptide binding]; other site 1006543006134 LytTr DNA-binding domain; Region: LytTR; pfam04397 1006543006135 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1006543006136 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1006543006137 putative substrate binding site [chemical binding]; other site 1006543006138 putative ATP binding site [chemical binding]; other site 1006543006139 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1006543006140 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1006543006141 substrate binding [chemical binding]; other site 1006543006142 active site 1006543006143 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1006543006144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1006543006145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1006543006146 DNA binding site [nucleotide binding] 1006543006147 domain linker motif; other site 1006543006148 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1006543006149 dimerization interface [polypeptide binding]; other site 1006543006150 ligand binding site [chemical binding]; other site 1006543006151 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1006543006152 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1006543006153 CPxP motif; other site 1006543006154 Predicted transporter component [General function prediction only]; Region: COG2391 1006543006155 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1006543006156 Sulphur transport; Region: Sulf_transp; pfam04143 1006543006157 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1006543006158 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1006543006159 CoA binding domain; Region: CoA_binding; pfam02629 1006543006160 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1006543006161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1006543006162 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1006543006163 ABC transporter; Region: ABC_tran_2; pfam12848 1006543006164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1006543006165 UGMP family protein; Validated; Region: PRK09604 1006543006166 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1006543006167 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1006543006168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543006169 Coenzyme A binding pocket [chemical binding]; other site 1006543006170 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1006543006171 Glycoprotease family; Region: Peptidase_M22; pfam00814 1006543006172 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1006543006173 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1006543006174 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1006543006175 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1006543006176 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1006543006177 PYR/PP interface [polypeptide binding]; other site 1006543006178 dimer interface [polypeptide binding]; other site 1006543006179 TPP binding site [chemical binding]; other site 1006543006180 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1006543006181 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1006543006182 TPP-binding site [chemical binding]; other site 1006543006183 dimer interface [polypeptide binding]; other site 1006543006184 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 1006543006185 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1006543006186 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1006543006187 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1006543006188 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1006543006189 2-isopropylmalate synthase; Validated; Region: PRK00915 1006543006190 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1006543006191 active site 1006543006192 catalytic residues [active] 1006543006193 metal binding site [ion binding]; metal-binding site 1006543006194 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1006543006195 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1006543006196 tartrate dehydrogenase; Region: TTC; TIGR02089 1006543006197 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1006543006198 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1006543006199 substrate binding site [chemical binding]; other site 1006543006200 ligand binding site [chemical binding]; other site 1006543006201 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1006543006202 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1006543006203 substrate binding site [chemical binding]; other site 1006543006204 threonine dehydratase; Validated; Region: PRK08639 1006543006205 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1006543006206 tetramer interface [polypeptide binding]; other site 1006543006207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543006208 catalytic residue [active] 1006543006209 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1006543006210 putative Ile/Val binding site [chemical binding]; other site 1006543006211 hypothetical protein; Provisional; Region: PRK04351 1006543006212 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1006543006213 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1006543006214 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1006543006215 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1006543006216 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1006543006217 RNA binding site [nucleotide binding]; other site 1006543006218 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1006543006219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1006543006220 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1006543006221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1006543006222 DNA binding residues [nucleotide binding] 1006543006223 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1006543006224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543006225 ATP binding site [chemical binding]; other site 1006543006226 Mg2+ binding site [ion binding]; other site 1006543006227 G-X-G motif; other site 1006543006228 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1006543006229 anti sigma factor interaction site; other site 1006543006230 regulatory phosphorylation site [posttranslational modification]; other site 1006543006231 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1006543006232 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1006543006233 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1006543006234 PemK-like protein; Region: PemK; pfam02452 1006543006235 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1006543006236 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1006543006237 active site 1006543006238 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1006543006239 dimer interface [polypeptide binding]; other site 1006543006240 substrate binding site [chemical binding]; other site 1006543006241 catalytic residues [active] 1006543006242 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1006543006243 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1006543006244 Predicted membrane protein [Function unknown]; Region: COG3428 1006543006245 Bacterial PH domain; Region: DUF304; pfam03703 1006543006246 Bacterial PH domain; Region: DUF304; pfam03703 1006543006247 Bacterial PH domain; Region: DUF304; cl01348 1006543006248 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 1006543006249 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1006543006250 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1006543006251 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1006543006252 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1006543006253 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1006543006254 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1006543006255 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1006543006256 Ligand Binding Site [chemical binding]; other site 1006543006257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1006543006258 dimer interface [polypeptide binding]; other site 1006543006259 phosphorylation site [posttranslational modification] 1006543006260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543006261 ATP binding site [chemical binding]; other site 1006543006262 Mg2+ binding site [ion binding]; other site 1006543006263 G-X-G motif; other site 1006543006264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1006543006265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543006266 active site 1006543006267 phosphorylation site [posttranslational modification] 1006543006268 intermolecular recognition site; other site 1006543006269 dimerization interface [polypeptide binding]; other site 1006543006270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1006543006271 DNA binding site [nucleotide binding] 1006543006272 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1006543006273 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1006543006274 ATP binding site [chemical binding]; other site 1006543006275 Mg++ binding site [ion binding]; other site 1006543006276 motif III; other site 1006543006277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1006543006278 nucleotide binding region [chemical binding]; other site 1006543006279 ATP-binding site [chemical binding]; other site 1006543006280 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1006543006281 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1006543006282 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1006543006283 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1006543006284 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1006543006285 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1006543006286 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1006543006287 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1006543006288 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1006543006289 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1006543006290 putative homodimer interface [polypeptide binding]; other site 1006543006291 putative homotetramer interface [polypeptide binding]; other site 1006543006292 allosteric switch controlling residues; other site 1006543006293 putative metal binding site [ion binding]; other site 1006543006294 putative homodimer-homodimer interface [polypeptide binding]; other site 1006543006295 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1006543006296 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1006543006297 putative active site [active] 1006543006298 catalytic site [active] 1006543006299 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1006543006300 putative active site [active] 1006543006301 catalytic site [active] 1006543006302 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1006543006303 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1006543006304 Zn2+ binding site [ion binding]; other site 1006543006305 Mg2+ binding site [ion binding]; other site 1006543006306 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1006543006307 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1006543006308 thiamine phosphate binding site [chemical binding]; other site 1006543006309 active site 1006543006310 pyrophosphate binding site [ion binding]; other site 1006543006311 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1006543006312 substrate binding site [chemical binding]; other site 1006543006313 multimerization interface [polypeptide binding]; other site 1006543006314 ATP binding site [chemical binding]; other site 1006543006315 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1006543006316 dimer interface [polypeptide binding]; other site 1006543006317 substrate binding site [chemical binding]; other site 1006543006318 ATP binding site [chemical binding]; other site 1006543006319 thiaminase II; Region: salvage_TenA; TIGR04306 1006543006320 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1006543006321 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1006543006322 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1006543006323 dimer interface [polypeptide binding]; other site 1006543006324 ssDNA binding site [nucleotide binding]; other site 1006543006325 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1006543006326 YwpF-like protein; Region: YwpF; pfam14183 1006543006327 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1006543006328 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1006543006329 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1006543006330 hinge; other site 1006543006331 active site 1006543006332 Predicted membrane protein [Function unknown]; Region: COG4836 1006543006333 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 1006543006334 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1006543006335 gamma subunit interface [polypeptide binding]; other site 1006543006336 epsilon subunit interface [polypeptide binding]; other site 1006543006337 LBP interface [polypeptide binding]; other site 1006543006338 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1006543006339 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1006543006340 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1006543006341 alpha subunit interaction interface [polypeptide binding]; other site 1006543006342 Walker A motif; other site 1006543006343 ATP binding site [chemical binding]; other site 1006543006344 Walker B motif; other site 1006543006345 inhibitor binding site; inhibition site 1006543006346 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1006543006347 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1006543006348 core domain interface [polypeptide binding]; other site 1006543006349 delta subunit interface [polypeptide binding]; other site 1006543006350 epsilon subunit interface [polypeptide binding]; other site 1006543006351 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1006543006352 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1006543006353 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1006543006354 beta subunit interaction interface [polypeptide binding]; other site 1006543006355 Walker A motif; other site 1006543006356 ATP binding site [chemical binding]; other site 1006543006357 Walker B motif; other site 1006543006358 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1006543006359 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1006543006360 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1006543006361 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1006543006362 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1006543006363 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1006543006364 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1006543006365 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1006543006366 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1006543006367 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1006543006368 active site 1006543006369 homodimer interface [polypeptide binding]; other site 1006543006370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1006543006371 active site 1006543006372 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1006543006373 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1006543006374 dimer interface [polypeptide binding]; other site 1006543006375 active site 1006543006376 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1006543006377 folate binding site [chemical binding]; other site 1006543006378 hypothetical protein; Provisional; Region: PRK13690 1006543006379 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1006543006380 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1006543006381 active site 1006543006382 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1006543006383 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1006543006384 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1006543006385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543006386 S-adenosylmethionine binding site [chemical binding]; other site 1006543006387 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1006543006388 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1006543006389 RF-1 domain; Region: RF-1; pfam00472 1006543006390 thymidine kinase; Provisional; Region: PRK04296 1006543006391 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1006543006392 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1006543006393 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1006543006394 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1006543006395 RNA binding site [nucleotide binding]; other site 1006543006396 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1006543006397 multimer interface [polypeptide binding]; other site 1006543006398 Walker A motif; other site 1006543006399 ATP binding site [chemical binding]; other site 1006543006400 Walker B motif; other site 1006543006401 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1006543006402 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1006543006403 NAD binding site [chemical binding]; other site 1006543006404 catalytic residues [active] 1006543006405 Predicted transcriptional regulators [Transcription]; Region: COG1733 1006543006406 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1006543006407 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1006543006408 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1006543006409 hinge; other site 1006543006410 active site 1006543006411 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1006543006412 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1006543006413 intersubunit interface [polypeptide binding]; other site 1006543006414 active site 1006543006415 zinc binding site [ion binding]; other site 1006543006416 Na+ binding site [ion binding]; other site 1006543006417 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1006543006418 CTP synthetase; Validated; Region: pyrG; PRK05380 1006543006419 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1006543006420 Catalytic site [active] 1006543006421 active site 1006543006422 UTP binding site [chemical binding]; other site 1006543006423 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1006543006424 active site 1006543006425 putative oxyanion hole; other site 1006543006426 catalytic triad [active] 1006543006427 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1006543006428 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1006543006429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543006430 Coenzyme A binding pocket [chemical binding]; other site 1006543006431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1006543006432 Coenzyme A binding pocket [chemical binding]; other site 1006543006433 pantothenate kinase; Provisional; Region: PRK13317 1006543006434 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1006543006435 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1006543006436 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1006543006437 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1006543006438 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1006543006439 metal binding site [ion binding]; metal-binding site 1006543006440 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1006543006441 Predicted membrane protein [Function unknown]; Region: COG4270 1006543006442 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1006543006443 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1006543006444 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1006543006445 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1006543006446 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1006543006447 intersubunit interface [polypeptide binding]; other site 1006543006448 active site 1006543006449 catalytic residue [active] 1006543006450 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1006543006451 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1006543006452 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1006543006453 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1006543006454 dimerization interface [polypeptide binding]; other site 1006543006455 DPS ferroxidase diiron center [ion binding]; other site 1006543006456 ion pore; other site 1006543006457 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1006543006458 EVE domain; Region: EVE; cl00728 1006543006459 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1006543006460 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1006543006461 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1006543006462 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1006543006463 NAD(P) binding site [chemical binding]; other site 1006543006464 putative active site [active] 1006543006465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1006543006466 dimerization interface [polypeptide binding]; other site 1006543006467 putative DNA binding site [nucleotide binding]; other site 1006543006468 putative Zn2+ binding site [ion binding]; other site 1006543006469 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1006543006470 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1006543006471 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1006543006472 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1006543006473 catalytic residues [active] 1006543006474 SAP domain; Region: SAP; pfam02037 1006543006475 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543006476 MULE transposase domain; Region: MULE; pfam10551 1006543006477 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1006543006478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543006479 active site 1006543006480 motif I; other site 1006543006481 motif II; other site 1006543006482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543006483 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1006543006484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543006485 Walker A/P-loop; other site 1006543006486 ATP binding site [chemical binding]; other site 1006543006487 Q-loop/lid; other site 1006543006488 ABC transporter signature motif; other site 1006543006489 Walker B; other site 1006543006490 D-loop; other site 1006543006491 H-loop/switch region; other site 1006543006492 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1006543006493 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1006543006494 glutaminase active site [active] 1006543006495 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1006543006496 dimer interface [polypeptide binding]; other site 1006543006497 active site 1006543006498 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1006543006499 dimer interface [polypeptide binding]; other site 1006543006500 active site 1006543006501 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1006543006502 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1006543006503 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1006543006504 active site 1006543006505 P-loop; other site 1006543006506 phosphorylation site [posttranslational modification] 1006543006507 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1006543006508 HTH domain; Region: HTH_11; pfam08279 1006543006509 Mga helix-turn-helix domain; Region: Mga; pfam05043 1006543006510 PRD domain; Region: PRD; pfam00874 1006543006511 PRD domain; Region: PRD; pfam00874 1006543006512 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1006543006513 active site 1006543006514 P-loop; other site 1006543006515 phosphorylation site [posttranslational modification] 1006543006516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1006543006517 active site 1006543006518 phosphorylation site [posttranslational modification] 1006543006519 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1006543006520 active site 1006543006521 phosphorylation site [posttranslational modification] 1006543006522 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1006543006523 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1006543006524 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1006543006525 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543006526 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1006543006527 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543006528 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543006529 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543006530 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543006531 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543006532 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543006533 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1006543006534 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1006543006535 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1006543006536 active site 1006543006537 substrate binding site [chemical binding]; other site 1006543006538 metal binding site [ion binding]; metal-binding site 1006543006539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1006543006540 YbbR-like protein; Region: YbbR; pfam07949 1006543006541 TIGR00159 family protein; Region: TIGR00159 1006543006542 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1006543006543 Arginase family; Region: Arginase; cd09989 1006543006544 active site 1006543006545 Mn binding site [ion binding]; other site 1006543006546 oligomer interface [polypeptide binding]; other site 1006543006547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1006543006548 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1006543006549 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1006543006550 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1006543006551 Walker A motif; other site 1006543006552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543006553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543006554 putative substrate translocation pore; other site 1006543006555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543006556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543006557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543006558 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1006543006559 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1006543006560 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1006543006561 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1006543006562 substrate binding site; other site 1006543006563 dimerization interface; other site 1006543006564 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1006543006565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1006543006566 Nucleoside recognition; Region: Gate; pfam07670 1006543006567 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1006543006568 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543006569 ABC-ATPase subunit interface; other site 1006543006570 dimer interface [polypeptide binding]; other site 1006543006571 putative PBP binding regions; other site 1006543006572 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1006543006573 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1006543006574 ABC-ATPase subunit interface; other site 1006543006575 dimer interface [polypeptide binding]; other site 1006543006576 putative PBP binding regions; other site 1006543006577 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1006543006578 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1006543006579 siderophore binding site; other site 1006543006580 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1006543006581 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1006543006582 dimer interface [polypeptide binding]; other site 1006543006583 active site 1006543006584 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1006543006585 substrate binding site [chemical binding]; other site 1006543006586 catalytic residue [active] 1006543006587 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1006543006588 IucA / IucC family; Region: IucA_IucC; pfam04183 1006543006589 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1006543006590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543006591 putative substrate translocation pore; other site 1006543006592 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1006543006593 IucA / IucC family; Region: IucA_IucC; pfam04183 1006543006594 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1006543006595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1006543006596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1006543006597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1006543006598 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1006543006599 Asp23 family; Region: Asp23; pfam03780 1006543006600 Small integral membrane protein [Function unknown]; Region: COG5547 1006543006601 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1006543006602 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1006543006603 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1006543006604 putative NAD(P) binding site [chemical binding]; other site 1006543006605 dimer interface [polypeptide binding]; other site 1006543006606 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1006543006607 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1006543006608 NAD(P) binding site [chemical binding]; other site 1006543006609 substrate binding site [chemical binding]; other site 1006543006610 dimer interface [polypeptide binding]; other site 1006543006611 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1006543006612 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1006543006613 beta-galactosidase; Region: BGL; TIGR03356 1006543006614 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1006543006615 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1006543006616 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1006543006617 active site 1006543006618 P-loop; other site 1006543006619 phosphorylation site [posttranslational modification] 1006543006620 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1006543006621 methionine cluster; other site 1006543006622 active site 1006543006623 phosphorylation site [posttranslational modification] 1006543006624 metal binding site [ion binding]; metal-binding site 1006543006625 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1006543006626 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1006543006627 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1006543006628 putative substrate binding site [chemical binding]; other site 1006543006629 putative ATP binding site [chemical binding]; other site 1006543006630 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1006543006631 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1006543006632 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1006543006633 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1006543006634 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1006543006635 NAD-dependent deacetylase; Provisional; Region: PRK00481 1006543006636 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1006543006637 NAD+ binding site [chemical binding]; other site 1006543006638 substrate binding site [chemical binding]; other site 1006543006639 putative Zn binding site [ion binding]; other site 1006543006640 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1006543006641 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543006642 MULE transposase domain; Region: MULE; pfam10551 1006543006643 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1006543006644 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1006543006645 active site 1006543006646 catalytic tetrad [active] 1006543006647 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1006543006648 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1006543006649 DNA binding residues [nucleotide binding] 1006543006650 putative dimer interface [polypeptide binding]; other site 1006543006651 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1006543006652 substrate binding site [chemical binding]; other site 1006543006653 catalytic residues [active] 1006543006654 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1006543006655 Peptidase family M23; Region: Peptidase_M23; pfam01551 1006543006656 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1006543006657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1006543006658 active site 1006543006659 motif I; other site 1006543006660 motif II; other site 1006543006661 MAP domain; Region: MAP; pfam03642 1006543006662 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1006543006663 acetolactate synthase; Reviewed; Region: PRK08617 1006543006664 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1006543006665 PYR/PP interface [polypeptide binding]; other site 1006543006666 dimer interface [polypeptide binding]; other site 1006543006667 TPP binding site [chemical binding]; other site 1006543006668 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1006543006669 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1006543006670 TPP-binding site [chemical binding]; other site 1006543006671 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1006543006672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543006673 Walker A motif; other site 1006543006674 ATP binding site [chemical binding]; other site 1006543006675 Walker B motif; other site 1006543006676 arginine finger; other site 1006543006677 Predicted helicase [General function prediction only]; Region: COG4889 1006543006678 Predicted helicase [General function prediction only]; Region: COG4889 1006543006679 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1006543006680 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1006543006681 23S rRNA interface [nucleotide binding]; other site 1006543006682 L3 interface [polypeptide binding]; other site 1006543006683 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1006543006684 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1006543006685 dimerization interface 3.5A [polypeptide binding]; other site 1006543006686 active site 1006543006687 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1006543006688 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1006543006689 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1006543006690 Walker A/P-loop; other site 1006543006691 ATP binding site [chemical binding]; other site 1006543006692 Q-loop/lid; other site 1006543006693 ABC transporter signature motif; other site 1006543006694 Walker B; other site 1006543006695 D-loop; other site 1006543006696 H-loop/switch region; other site 1006543006697 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1006543006698 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1006543006699 Walker A/P-loop; other site 1006543006700 ATP binding site [chemical binding]; other site 1006543006701 Q-loop/lid; other site 1006543006702 ABC transporter signature motif; other site 1006543006703 Walker B; other site 1006543006704 D-loop; other site 1006543006705 H-loop/switch region; other site 1006543006706 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1006543006707 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1006543006708 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1006543006709 alphaNTD homodimer interface [polypeptide binding]; other site 1006543006710 alphaNTD - beta interaction site [polypeptide binding]; other site 1006543006711 alphaNTD - beta' interaction site [polypeptide binding]; other site 1006543006712 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1006543006713 30S ribosomal protein S11; Validated; Region: PRK05309 1006543006714 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1006543006715 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1006543006716 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1006543006717 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1006543006718 rRNA binding site [nucleotide binding]; other site 1006543006719 predicted 30S ribosome binding site; other site 1006543006720 adenylate kinase; Reviewed; Region: adk; PRK00279 1006543006721 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1006543006722 AMP-binding site [chemical binding]; other site 1006543006723 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1006543006724 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1006543006725 SecY translocase; Region: SecY; pfam00344 1006543006726 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1006543006727 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1006543006728 23S rRNA binding site [nucleotide binding]; other site 1006543006729 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1006543006730 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1006543006731 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1006543006732 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1006543006733 5S rRNA interface [nucleotide binding]; other site 1006543006734 L27 interface [polypeptide binding]; other site 1006543006735 23S rRNA interface [nucleotide binding]; other site 1006543006736 L5 interface [polypeptide binding]; other site 1006543006737 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1006543006738 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1006543006739 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1006543006740 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1006543006741 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1006543006742 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1006543006743 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1006543006744 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1006543006745 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1006543006746 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1006543006747 RNA binding site [nucleotide binding]; other site 1006543006748 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1006543006749 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1006543006750 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1006543006751 23S rRNA interface [nucleotide binding]; other site 1006543006752 putative translocon interaction site; other site 1006543006753 signal recognition particle (SRP54) interaction site; other site 1006543006754 L23 interface [polypeptide binding]; other site 1006543006755 trigger factor interaction site; other site 1006543006756 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1006543006757 23S rRNA interface [nucleotide binding]; other site 1006543006758 5S rRNA interface [nucleotide binding]; other site 1006543006759 putative antibiotic binding site [chemical binding]; other site 1006543006760 L25 interface [polypeptide binding]; other site 1006543006761 L27 interface [polypeptide binding]; other site 1006543006762 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1006543006763 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1006543006764 G-X-X-G motif; other site 1006543006765 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1006543006766 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1006543006767 putative translocon binding site; other site 1006543006768 protein-rRNA interface [nucleotide binding]; other site 1006543006769 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1006543006770 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1006543006771 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1006543006772 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1006543006773 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1006543006774 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1006543006775 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1006543006776 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1006543006777 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1006543006778 DNA topoisomerase III; Provisional; Region: PRK07726 1006543006779 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1006543006780 active site 1006543006781 putative interdomain interaction site [polypeptide binding]; other site 1006543006782 putative metal-binding site [ion binding]; other site 1006543006783 putative nucleotide binding site [chemical binding]; other site 1006543006784 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1006543006785 domain I; other site 1006543006786 DNA binding groove [nucleotide binding] 1006543006787 phosphate binding site [ion binding]; other site 1006543006788 domain II; other site 1006543006789 domain III; other site 1006543006790 nucleotide binding site [chemical binding]; other site 1006543006791 catalytic site [active] 1006543006792 domain IV; other site 1006543006793 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1006543006794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543006795 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1006543006796 Coenzyme A binding pocket [chemical binding]; other site 1006543006797 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1006543006798 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1006543006799 Predicted permeases [General function prediction only]; Region: COG0679 1006543006800 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1006543006801 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1006543006802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1006543006803 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1006543006804 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1006543006805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543006806 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543006807 putative substrate translocation pore; other site 1006543006808 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543006809 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1006543006810 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1006543006811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543006812 FeS/SAM binding site; other site 1006543006813 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1006543006814 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1006543006815 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1006543006816 GTP binding site; other site 1006543006817 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1006543006818 MoaE interaction surface [polypeptide binding]; other site 1006543006819 MoeB interaction surface [polypeptide binding]; other site 1006543006820 thiocarboxylated glycine; other site 1006543006821 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1006543006822 MoaE homodimer interface [polypeptide binding]; other site 1006543006823 MoaD interaction [polypeptide binding]; other site 1006543006824 active site residues [active] 1006543006825 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1006543006826 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1006543006827 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1006543006828 dimer interface [polypeptide binding]; other site 1006543006829 putative functional site; other site 1006543006830 putative MPT binding site; other site 1006543006831 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1006543006832 trimer interface [polypeptide binding]; other site 1006543006833 dimer interface [polypeptide binding]; other site 1006543006834 putative active site [active] 1006543006835 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1006543006836 MPT binding site; other site 1006543006837 trimer interface [polypeptide binding]; other site 1006543006838 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1006543006839 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1006543006840 ATP binding site [chemical binding]; other site 1006543006841 substrate interface [chemical binding]; other site 1006543006842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543006843 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1006543006844 Walker A/P-loop; other site 1006543006845 ATP binding site [chemical binding]; other site 1006543006846 Q-loop/lid; other site 1006543006847 ABC transporter signature motif; other site 1006543006848 Walker B; other site 1006543006849 D-loop; other site 1006543006850 H-loop/switch region; other site 1006543006851 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1006543006852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543006853 dimer interface [polypeptide binding]; other site 1006543006854 conserved gate region; other site 1006543006855 putative PBP binding loops; other site 1006543006856 ABC-ATPase subunit interface; other site 1006543006857 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1006543006858 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1006543006859 substrate binding pocket [chemical binding]; other site 1006543006860 membrane-bound complex binding site; other site 1006543006861 hinge residues; other site 1006543006862 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1006543006863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543006864 Coenzyme A binding pocket [chemical binding]; other site 1006543006865 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1006543006866 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1006543006867 active site 1006543006868 dimerization interface [polypeptide binding]; other site 1006543006869 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1006543006870 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1006543006871 intersubunit interface [polypeptide binding]; other site 1006543006872 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1006543006873 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1006543006874 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1006543006875 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1006543006876 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1006543006877 alpha-gamma subunit interface [polypeptide binding]; other site 1006543006878 beta-gamma subunit interface [polypeptide binding]; other site 1006543006879 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1006543006880 gamma-beta subunit interface [polypeptide binding]; other site 1006543006881 alpha-beta subunit interface [polypeptide binding]; other site 1006543006882 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1006543006883 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1006543006884 subunit interactions [polypeptide binding]; other site 1006543006885 active site 1006543006886 flap region; other site 1006543006887 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1006543006888 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1006543006889 dimer interface [polypeptide binding]; other site 1006543006890 catalytic residues [active] 1006543006891 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1006543006892 UreF; Region: UreF; pfam01730 1006543006893 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1006543006894 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1006543006895 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543006896 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543006897 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543006898 Helix-turn-helix domain; Region: HTH_18; pfam12833 1006543006899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1006543006900 Surface antigen [General function prediction only]; Region: COG3942 1006543006901 CHAP domain; Region: CHAP; pfam05257 1006543006902 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1006543006903 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1006543006904 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1006543006905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1006543006906 Surface antigen [General function prediction only]; Region: COG3942 1006543006907 CHAP domain; Region: CHAP; pfam05257 1006543006908 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1006543006909 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1006543006910 putative ligand binding site [chemical binding]; other site 1006543006911 putative NAD binding site [chemical binding]; other site 1006543006912 catalytic site [active] 1006543006913 hypothetical protein; Provisional; Region: PRK06753 1006543006914 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1006543006915 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1006543006916 Lysozyme subfamily 2; Region: LYZ2; smart00047 1006543006917 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1006543006918 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1006543006919 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1006543006920 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1006543006921 4Fe-4S binding domain; Region: Fer4; pfam00037 1006543006922 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1006543006923 [4Fe-4S] binding site [ion binding]; other site 1006543006924 molybdopterin cofactor binding site; other site 1006543006925 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1006543006926 molybdopterin cofactor binding site; other site 1006543006927 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543006928 MULE transposase domain; Region: MULE; pfam10551 1006543006929 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1006543006930 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1006543006931 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1006543006932 active site 1006543006933 Predicted transcriptional regulator [Transcription]; Region: COG2378 1006543006934 HTH domain; Region: HTH_11; pfam08279 1006543006935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1006543006936 CAAX protease self-immunity; Region: Abi; pfam02517 1006543006937 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543006938 MULE transposase domain; Region: MULE; pfam10551 1006543006939 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1006543006940 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1006543006941 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1006543006942 putative active site [active] 1006543006943 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1006543006944 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1006543006945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543006946 active site 1006543006947 motif I; other site 1006543006948 motif II; other site 1006543006949 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1006543006950 Sodium Bile acid symporter family; Region: SBF; pfam01758 1006543006951 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1006543006952 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1006543006953 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1006543006954 active site turn [active] 1006543006955 phosphorylation site [posttranslational modification] 1006543006956 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1006543006957 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1006543006958 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1006543006959 putative active site [active] 1006543006960 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1006543006961 putative hydrophobic ligand binding site [chemical binding]; other site 1006543006962 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1006543006963 oxidoreductase; Provisional; Region: PRK07985 1006543006964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1006543006965 NAD(P) binding site [chemical binding]; other site 1006543006966 active site 1006543006967 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1006543006968 amidohydrolase; Region: amidohydrolases; TIGR01891 1006543006969 metal binding site [ion binding]; metal-binding site 1006543006970 dimer interface [polypeptide binding]; other site 1006543006971 imidazolonepropionase; Validated; Region: PRK09356 1006543006972 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1006543006973 active site 1006543006974 urocanate hydratase; Provisional; Region: PRK05414 1006543006975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1006543006976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1006543006977 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1006543006978 dimerization interface [polypeptide binding]; other site 1006543006979 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1006543006980 active site 1006543006981 formimidoylglutamase; Provisional; Region: PRK13775 1006543006982 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1006543006983 putative active site [active] 1006543006984 putative metal binding site [ion binding]; other site 1006543006985 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1006543006986 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1006543006987 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1006543006988 active site 1006543006989 dimer interface [polypeptide binding]; other site 1006543006990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1006543006991 MOSC domain; Region: MOSC; pfam03473 1006543006992 3-alpha domain; Region: 3-alpha; pfam03475 1006543006993 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1006543006994 active site 1006543006995 catalytic residues [active] 1006543006996 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1006543006997 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1006543006998 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1006543006999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543007000 Walker A/P-loop; other site 1006543007001 ATP binding site [chemical binding]; other site 1006543007002 Q-loop/lid; other site 1006543007003 ABC transporter signature motif; other site 1006543007004 Walker B; other site 1006543007005 D-loop; other site 1006543007006 H-loop/switch region; other site 1006543007007 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1006543007008 Predicted membrane protein [Function unknown]; Region: COG3152 1006543007009 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1006543007010 active site 1006543007011 DNA binding site [nucleotide binding] 1006543007012 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1006543007013 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1006543007014 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1006543007015 homotetramer interface [polypeptide binding]; other site 1006543007016 FMN binding site [chemical binding]; other site 1006543007017 homodimer contacts [polypeptide binding]; other site 1006543007018 putative active site [active] 1006543007019 putative substrate binding site [chemical binding]; other site 1006543007020 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1006543007021 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1006543007022 oligomer interface [polypeptide binding]; other site 1006543007023 metal binding site [ion binding]; metal-binding site 1006543007024 metal binding site [ion binding]; metal-binding site 1006543007025 putative Cl binding site [ion binding]; other site 1006543007026 aspartate ring; other site 1006543007027 basic sphincter; other site 1006543007028 hydrophobic gate; other site 1006543007029 periplasmic entrance; other site 1006543007030 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1006543007031 active site 1006543007032 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1006543007033 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1006543007034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007035 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1006543007036 putative substrate translocation pore; other site 1006543007037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007038 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1006543007039 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1006543007040 HlyD family secretion protein; Region: HlyD_3; pfam13437 1006543007041 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1006543007042 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1006543007043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007044 putative substrate translocation pore; other site 1006543007045 Predicted membrane protein [Function unknown]; Region: COG4640 1006543007046 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1006543007047 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1006543007048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1006543007049 putative Zn2+ binding site [ion binding]; other site 1006543007050 putative DNA binding site [nucleotide binding]; other site 1006543007051 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1006543007052 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1006543007053 putative active site [active] 1006543007054 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1006543007055 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1006543007056 Walker A/P-loop; other site 1006543007057 ATP binding site [chemical binding]; other site 1006543007058 Q-loop/lid; other site 1006543007059 ABC transporter signature motif; other site 1006543007060 Walker B; other site 1006543007061 D-loop; other site 1006543007062 H-loop/switch region; other site 1006543007063 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1006543007064 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1006543007065 FtsX-like permease family; Region: FtsX; pfam02687 1006543007066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1006543007067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543007068 active site 1006543007069 phosphorylation site [posttranslational modification] 1006543007070 intermolecular recognition site; other site 1006543007071 dimerization interface [polypeptide binding]; other site 1006543007072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1006543007073 DNA binding site [nucleotide binding] 1006543007074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1006543007075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1006543007076 dimerization interface [polypeptide binding]; other site 1006543007077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1006543007078 dimer interface [polypeptide binding]; other site 1006543007079 phosphorylation site [posttranslational modification] 1006543007080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543007081 ATP binding site [chemical binding]; other site 1006543007082 Mg2+ binding site [ion binding]; other site 1006543007083 G-X-G motif; other site 1006543007084 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1006543007085 LytTr DNA-binding domain; Region: LytTR; smart00850 1006543007086 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1006543007087 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 1006543007088 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1006543007089 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1006543007090 L-lactate permease; Region: Lactate_perm; cl00701 1006543007091 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1006543007092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543007093 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1006543007094 Coenzyme A binding pocket [chemical binding]; other site 1006543007095 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1006543007096 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1006543007097 NAD(P) binding site [chemical binding]; other site 1006543007098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543007099 Coenzyme A binding pocket [chemical binding]; other site 1006543007100 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1006543007101 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1006543007102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543007103 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1006543007104 Predicted membrane protein [Function unknown]; Region: COG1511 1006543007105 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1006543007106 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1006543007107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1006543007108 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1006543007109 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1006543007110 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1006543007111 Cl binding site [ion binding]; other site 1006543007112 oligomer interface [polypeptide binding]; other site 1006543007113 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1006543007114 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1006543007115 active site turn [active] 1006543007116 phosphorylation site [posttranslational modification] 1006543007117 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1006543007118 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1006543007119 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1006543007120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1006543007121 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1006543007122 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1006543007123 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1006543007124 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1006543007125 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1006543007126 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1006543007127 MarR family; Region: MarR_2; pfam12802 1006543007128 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1006543007129 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1006543007130 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1006543007131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007132 putative substrate translocation pore; other site 1006543007133 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1006543007134 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1006543007135 DNA binding residues [nucleotide binding] 1006543007136 dimer interface [polypeptide binding]; other site 1006543007137 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1006543007138 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1006543007139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543007140 active site 1006543007141 phosphorylation site [posttranslational modification] 1006543007142 intermolecular recognition site; other site 1006543007143 dimerization interface [polypeptide binding]; other site 1006543007144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1006543007145 DNA binding residues [nucleotide binding] 1006543007146 dimerization interface [polypeptide binding]; other site 1006543007147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1006543007148 Histidine kinase; Region: HisKA_3; pfam07730 1006543007149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543007150 ATP binding site [chemical binding]; other site 1006543007151 Mg2+ binding site [ion binding]; other site 1006543007152 G-X-G motif; other site 1006543007153 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1006543007154 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1006543007155 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1006543007156 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1006543007157 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1006543007158 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1006543007159 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1006543007160 [4Fe-4S] binding site [ion binding]; other site 1006543007161 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1006543007162 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1006543007163 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1006543007164 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1006543007165 molybdopterin cofactor binding site; other site 1006543007166 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1006543007167 active site 1006543007168 SAM binding site [chemical binding]; other site 1006543007169 homodimer interface [polypeptide binding]; other site 1006543007170 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1006543007171 [2Fe-2S] cluster binding site [ion binding]; other site 1006543007172 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1006543007173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1006543007174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1006543007175 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1006543007176 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1006543007177 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1006543007178 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1006543007179 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1006543007180 putative active site [active] 1006543007181 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1006543007182 active site 1006543007183 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1006543007184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543007185 Coenzyme A binding pocket [chemical binding]; other site 1006543007186 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1006543007187 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1006543007188 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1006543007189 putative hydrophobic ligand binding site [chemical binding]; other site 1006543007190 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1006543007191 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1006543007192 intersubunit interface [polypeptide binding]; other site 1006543007193 YodA lipocalin-like domain; Region: YodA; pfam09223 1006543007194 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1006543007195 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1006543007196 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1006543007197 Thioredoxin; Region: Thioredoxin_4; cl17273 1006543007198 FemAB family; Region: FemAB; pfam02388 1006543007199 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1006543007200 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1006543007201 Walker A/P-loop; other site 1006543007202 ATP binding site [chemical binding]; other site 1006543007203 Q-loop/lid; other site 1006543007204 ABC transporter signature motif; other site 1006543007205 Walker B; other site 1006543007206 D-loop; other site 1006543007207 H-loop/switch region; other site 1006543007208 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1006543007209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543007210 dimer interface [polypeptide binding]; other site 1006543007211 conserved gate region; other site 1006543007212 putative PBP binding loops; other site 1006543007213 ABC-ATPase subunit interface; other site 1006543007214 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1006543007215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1006543007216 substrate binding pocket [chemical binding]; other site 1006543007217 membrane-bound complex binding site; other site 1006543007218 hinge residues; other site 1006543007219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543007221 putative substrate translocation pore; other site 1006543007222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007223 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1006543007224 catalytic core [active] 1006543007225 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1006543007226 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1006543007227 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1006543007228 B domain; Region: B; pfam02216 1006543007229 B domain; Region: B; pfam02216 1006543007230 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 1006543007231 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1006543007232 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1006543007233 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1006543007234 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1006543007235 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1006543007236 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1006543007237 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1006543007238 catalytic residue [active] 1006543007239 biotin synthase; Validated; Region: PRK06256 1006543007240 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543007241 FeS/SAM binding site; other site 1006543007242 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1006543007243 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1006543007244 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1006543007245 inhibitor-cofactor binding pocket; inhibition site 1006543007246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543007247 catalytic residue [active] 1006543007248 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1006543007249 AAA domain; Region: AAA_26; pfam13500 1006543007250 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1006543007251 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1006543007252 Walker A/P-loop; other site 1006543007253 ATP binding site [chemical binding]; other site 1006543007254 Q-loop/lid; other site 1006543007255 ABC transporter signature motif; other site 1006543007256 Walker B; other site 1006543007257 D-loop; other site 1006543007258 H-loop/switch region; other site 1006543007259 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1006543007260 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1006543007261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543007262 Walker A/P-loop; other site 1006543007263 ATP binding site [chemical binding]; other site 1006543007264 Q-loop/lid; other site 1006543007265 ABC transporter signature motif; other site 1006543007266 Walker B; other site 1006543007267 D-loop; other site 1006543007268 H-loop/switch region; other site 1006543007269 Predicted membrane protein [Function unknown]; Region: COG2246 1006543007270 GtrA-like protein; Region: GtrA; pfam04138 1006543007271 glycerate kinase; Region: TIGR00045 1006543007272 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1006543007273 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1006543007274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007275 putative substrate translocation pore; other site 1006543007276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1006543007277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1006543007278 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1006543007279 putative phosphoesterase; Region: acc_ester; TIGR03729 1006543007280 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1006543007281 Spore germination protein; Region: Spore_permease; cl17796 1006543007282 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1006543007283 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1006543007284 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1006543007285 Beta-lactamase; Region: Beta-lactamase; pfam00144 1006543007286 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1006543007287 extended (e) SDRs; Region: SDR_e; cd08946 1006543007288 NAD(P) binding site [chemical binding]; other site 1006543007289 active site 1006543007290 substrate binding site [chemical binding]; other site 1006543007291 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1006543007292 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1006543007293 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1006543007294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007295 putative substrate translocation pore; other site 1006543007296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543007298 dimer interface [polypeptide binding]; other site 1006543007299 conserved gate region; other site 1006543007300 ABC-ATPase subunit interface; other site 1006543007301 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1006543007302 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1006543007303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543007304 dimer interface [polypeptide binding]; other site 1006543007305 conserved gate region; other site 1006543007306 putative PBP binding loops; other site 1006543007307 ABC-ATPase subunit interface; other site 1006543007308 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1006543007309 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1006543007310 Walker A/P-loop; other site 1006543007311 ATP binding site [chemical binding]; other site 1006543007312 Q-loop/lid; other site 1006543007313 ABC transporter signature motif; other site 1006543007314 Walker B; other site 1006543007315 D-loop; other site 1006543007316 H-loop/switch region; other site 1006543007317 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1006543007318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1006543007319 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1006543007320 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1006543007321 amino acid transporter; Region: 2A0306; TIGR00909 1006543007322 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1006543007323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1006543007324 substrate binding pocket [chemical binding]; other site 1006543007325 catalytic triad [active] 1006543007326 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1006543007327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007328 putative substrate translocation pore; other site 1006543007329 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1006543007330 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1006543007331 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1006543007332 Walker A/P-loop; other site 1006543007333 ATP binding site [chemical binding]; other site 1006543007334 Q-loop/lid; other site 1006543007335 ABC transporter signature motif; other site 1006543007336 Walker B; other site 1006543007337 D-loop; other site 1006543007338 H-loop/switch region; other site 1006543007339 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1006543007340 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1006543007341 oligomer interface [polypeptide binding]; other site 1006543007342 active site 1006543007343 metal binding site [ion binding]; metal-binding site 1006543007344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 1006543007345 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1006543007346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1006543007347 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1006543007348 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1006543007349 active site 1006543007350 FMN binding site [chemical binding]; other site 1006543007351 substrate binding site [chemical binding]; other site 1006543007352 3Fe-4S cluster binding site [ion binding]; other site 1006543007353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007354 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543007355 putative substrate translocation pore; other site 1006543007356 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1006543007357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543007358 Walker A/P-loop; other site 1006543007359 ATP binding site [chemical binding]; other site 1006543007360 Q-loop/lid; other site 1006543007361 ABC transporter signature motif; other site 1006543007362 Walker B; other site 1006543007363 D-loop; other site 1006543007364 H-loop/switch region; other site 1006543007365 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1006543007366 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1006543007367 Walker A/P-loop; other site 1006543007368 ATP binding site [chemical binding]; other site 1006543007369 Q-loop/lid; other site 1006543007370 ABC transporter signature motif; other site 1006543007371 Walker B; other site 1006543007372 D-loop; other site 1006543007373 H-loop/switch region; other site 1006543007374 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1006543007375 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1006543007376 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1006543007377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543007378 dimer interface [polypeptide binding]; other site 1006543007379 conserved gate region; other site 1006543007380 putative PBP binding loops; other site 1006543007381 ABC-ATPase subunit interface; other site 1006543007382 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1006543007383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1006543007384 dimer interface [polypeptide binding]; other site 1006543007385 conserved gate region; other site 1006543007386 putative PBP binding loops; other site 1006543007387 ABC-ATPase subunit interface; other site 1006543007388 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1006543007389 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1006543007390 substrate binding site [chemical binding]; other site 1006543007391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1006543007392 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1006543007393 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1006543007394 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1006543007395 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1006543007396 classical (c) SDRs; Region: SDR_c; cd05233 1006543007397 NAD(P) binding site [chemical binding]; other site 1006543007398 active site 1006543007399 AbgT putative transporter family; Region: ABG_transport; pfam03806 1006543007400 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1006543007401 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1006543007402 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1006543007403 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1006543007404 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1006543007405 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1006543007406 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1006543007407 classical (c) SDRs; Region: SDR_c; cd05233 1006543007408 NAD(P) binding site [chemical binding]; other site 1006543007409 active site 1006543007410 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1006543007411 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543007412 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1006543007413 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1006543007414 PLD-like domain; Region: PLDc_2; pfam13091 1006543007415 putative homodimer interface [polypeptide binding]; other site 1006543007416 putative active site [active] 1006543007417 catalytic site [active] 1006543007418 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1006543007419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1006543007420 ATP binding site [chemical binding]; other site 1006543007421 putative Mg++ binding site [ion binding]; other site 1006543007422 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1006543007423 nucleotide binding region [chemical binding]; other site 1006543007424 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1006543007425 ATP-binding site [chemical binding]; other site 1006543007426 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1006543007427 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1006543007428 active site 1006543007429 8-oxo-dGMP binding site [chemical binding]; other site 1006543007430 nudix motif; other site 1006543007431 metal binding site [ion binding]; metal-binding site 1006543007432 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1006543007433 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1006543007434 active site 1006543007435 substrate binding site [chemical binding]; other site 1006543007436 metal binding site [ion binding]; metal-binding site 1006543007437 H+ Antiporter protein; Region: 2A0121; TIGR00900 1006543007438 G5 domain; Region: G5; pfam07501 1006543007439 G5 domain; Region: G5; pfam07501 1006543007440 G5 domain; Region: G5; pfam07501 1006543007441 G5 domain; Region: G5; pfam07501 1006543007442 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1006543007443 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543007444 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543007445 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1006543007446 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543007447 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1006543007448 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1006543007449 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1006543007450 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1006543007451 active site 1006543007452 tetramer interface; other site 1006543007453 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1006543007454 Fibronectin binding repeat; Region: Fn_bind; pfam02986 1006543007455 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1006543007456 GntP family permease; Region: GntP_permease; pfam02447 1006543007457 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1006543007458 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1006543007459 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1006543007460 N- and C-terminal domain interface [polypeptide binding]; other site 1006543007461 active site 1006543007462 catalytic site [active] 1006543007463 metal binding site [ion binding]; metal-binding site 1006543007464 carbohydrate binding site [chemical binding]; other site 1006543007465 ATP binding site [chemical binding]; other site 1006543007466 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1006543007467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1006543007468 DNA-binding site [nucleotide binding]; DNA binding site 1006543007469 FCD domain; Region: FCD; pfam07729 1006543007470 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1006543007471 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1006543007472 DNA binding residues [nucleotide binding] 1006543007473 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1006543007474 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1006543007475 synthetase active site [active] 1006543007476 NTP binding site [chemical binding]; other site 1006543007477 metal binding site [ion binding]; metal-binding site 1006543007478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1006543007479 Predicted membrane protein [Function unknown]; Region: COG1289 1006543007480 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1006543007481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007482 D-galactonate transporter; Region: 2A0114; TIGR00893 1006543007483 putative substrate translocation pore; other site 1006543007484 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1006543007485 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1006543007486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1006543007487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1006543007488 putative substrate translocation pore; other site 1006543007489 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1006543007490 MarR family; Region: MarR; pfam01047 1006543007491 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1006543007492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543007493 Walker A/P-loop; other site 1006543007494 ATP binding site [chemical binding]; other site 1006543007495 Q-loop/lid; other site 1006543007496 ABC transporter signature motif; other site 1006543007497 Walker B; other site 1006543007498 D-loop; other site 1006543007499 H-loop/switch region; other site 1006543007500 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1006543007501 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1006543007502 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 1006543007503 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1006543007504 Predicted esterase [General function prediction only]; Region: COG0400 1006543007505 putative hydrolase; Provisional; Region: PRK11460 1006543007506 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1006543007507 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1006543007508 Zn binding site [ion binding]; other site 1006543007509 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1006543007510 Zn binding site [ion binding]; other site 1006543007511 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1006543007512 MarR family; Region: MarR; pfam01047 1006543007513 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1006543007514 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1006543007515 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1006543007516 putative metal binding site [ion binding]; other site 1006543007517 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1006543007518 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1006543007519 dimer interface [polypeptide binding]; other site 1006543007520 FMN binding site [chemical binding]; other site 1006543007521 D-lactate dehydrogenase; Provisional; Region: PRK12480 1006543007522 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1006543007523 homodimer interface [polypeptide binding]; other site 1006543007524 ligand binding site [chemical binding]; other site 1006543007525 NAD binding site [chemical binding]; other site 1006543007526 catalytic site [active] 1006543007527 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1006543007528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1006543007529 active site 1006543007530 motif I; other site 1006543007531 motif II; other site 1006543007532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1006543007533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1006543007534 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1006543007535 Walker A/P-loop; other site 1006543007536 ATP binding site [chemical binding]; other site 1006543007537 Q-loop/lid; other site 1006543007538 ABC transporter signature motif; other site 1006543007539 Walker B; other site 1006543007540 D-loop; other site 1006543007541 H-loop/switch region; other site 1006543007542 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1006543007543 active site 1006543007544 catalytic site [active] 1006543007545 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1006543007546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543007547 Coenzyme A binding pocket [chemical binding]; other site 1006543007548 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1006543007549 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1006543007550 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1006543007551 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1006543007552 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1006543007553 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1006543007554 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1006543007555 EamA-like transporter family; Region: EamA; pfam00892 1006543007556 EamA-like transporter family; Region: EamA; pfam00892 1006543007557 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1006543007558 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1006543007559 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1006543007560 catalytic residues [active] 1006543007561 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1006543007562 active site 1006543007563 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1006543007564 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1006543007565 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1006543007566 active site turn [active] 1006543007567 phosphorylation site [posttranslational modification] 1006543007568 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1006543007569 HPr interaction site; other site 1006543007570 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1006543007571 active site 1006543007572 phosphorylation site [posttranslational modification] 1006543007573 pyruvate oxidase; Provisional; Region: PRK08611 1006543007574 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1006543007575 PYR/PP interface [polypeptide binding]; other site 1006543007576 tetramer interface [polypeptide binding]; other site 1006543007577 dimer interface [polypeptide binding]; other site 1006543007578 TPP binding site [chemical binding]; other site 1006543007579 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1006543007580 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1006543007581 TPP-binding site [chemical binding]; other site 1006543007582 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1006543007583 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1006543007584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1006543007585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1006543007586 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1006543007587 putative dimerization interface [polypeptide binding]; other site 1006543007588 Surface antigen [General function prediction only]; Region: COG3942 1006543007589 CHAP domain; Region: CHAP; pfam05257 1006543007590 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1006543007591 homodimer interface [polypeptide binding]; other site 1006543007592 catalytic residues [active] 1006543007593 NAD binding site [chemical binding]; other site 1006543007594 substrate binding pocket [chemical binding]; other site 1006543007595 flexible flap; other site 1006543007596 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1006543007597 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1006543007598 dimer interface [polypeptide binding]; other site 1006543007599 active site 1006543007600 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1006543007601 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1006543007602 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1006543007603 DNA binding site [nucleotide binding] 1006543007604 active site 1006543007605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543007606 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1006543007607 Walker A motif; other site 1006543007608 ATP binding site [chemical binding]; other site 1006543007609 Walker B motif; other site 1006543007610 arginine finger; other site 1006543007611 UvrB/uvrC motif; Region: UVR; pfam02151 1006543007612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1006543007613 Walker A motif; other site 1006543007614 ATP binding site [chemical binding]; other site 1006543007615 Walker B motif; other site 1006543007616 arginine finger; other site 1006543007617 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1006543007618 Virus attachment protein p12 family; Region: P12; pfam12669 1006543007619 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1006543007620 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1006543007621 G1 box; other site 1006543007622 GTP/Mg2+ binding site [chemical binding]; other site 1006543007623 Switch I region; other site 1006543007624 G2 box; other site 1006543007625 G3 box; other site 1006543007626 Switch II region; other site 1006543007627 G4 box; other site 1006543007628 G5 box; other site 1006543007629 Nucleoside recognition; Region: Gate; pfam07670 1006543007630 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1006543007631 Nucleoside recognition; Region: Gate; pfam07670 1006543007632 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1006543007633 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1006543007634 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1006543007635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1006543007636 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1006543007637 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1006543007638 Glutamate binding site [chemical binding]; other site 1006543007639 homodimer interface [polypeptide binding]; other site 1006543007640 NAD binding site [chemical binding]; other site 1006543007641 catalytic residues [active] 1006543007642 maltose O-acetyltransferase; Provisional; Region: PRK10092 1006543007643 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1006543007644 active site 1006543007645 substrate binding site [chemical binding]; other site 1006543007646 trimer interface [polypeptide binding]; other site 1006543007647 CoA binding site [chemical binding]; other site 1006543007648 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1006543007649 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1006543007650 metal-binding site [ion binding] 1006543007651 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1006543007652 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1006543007653 metal-binding site [ion binding] 1006543007654 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1006543007655 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1006543007656 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1006543007657 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1006543007658 metal-binding site [ion binding] 1006543007659 D-lactate dehydrogenase; Validated; Region: PRK08605 1006543007660 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1006543007661 homodimer interface [polypeptide binding]; other site 1006543007662 ligand binding site [chemical binding]; other site 1006543007663 NAD binding site [chemical binding]; other site 1006543007664 catalytic site [active] 1006543007665 transaminase; Reviewed; Region: PRK08068 1006543007666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1006543007667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543007668 homodimer interface [polypeptide binding]; other site 1006543007669 catalytic residue [active] 1006543007670 phytoene desaturase; Region: crtI_fam; TIGR02734 1006543007671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1006543007672 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1006543007673 active site lid residues [active] 1006543007674 substrate binding pocket [chemical binding]; other site 1006543007675 catalytic residues [active] 1006543007676 substrate-Mg2+ binding site; other site 1006543007677 aspartate-rich region 1; other site 1006543007678 aspartate-rich region 2; other site 1006543007679 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1006543007680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1006543007681 active site 1006543007682 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1006543007683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1006543007684 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 1006543007685 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1006543007686 Surface antigen [General function prediction only]; Region: COG3942 1006543007687 CHAP domain; Region: CHAP; pfam05257 1006543007688 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1006543007689 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1006543007690 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1006543007691 catalytic triad [active] 1006543007692 catalytic triad [active] 1006543007693 oxyanion hole [active] 1006543007694 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1006543007695 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1006543007696 catalytic residue [active] 1006543007697 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1006543007698 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1006543007699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1006543007700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1006543007701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1006543007702 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1006543007703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1006543007704 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1006543007705 NmrA-like family; Region: NmrA; pfam05368 1006543007706 NADP binding site [chemical binding]; other site 1006543007707 active site 1006543007708 regulatory binding site [polypeptide binding]; other site 1006543007709 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 1006543007710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1006543007711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1006543007712 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1006543007713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1006543007714 NAD(P) binding site [chemical binding]; other site 1006543007715 active site 1006543007716 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1006543007717 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1006543007718 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1006543007719 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1006543007720 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1006543007721 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1006543007722 Nucleoside recognition; Region: Gate; pfam07670 1006543007723 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1006543007724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1006543007725 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1006543007726 Integrase core domain; Region: rve; pfam00665 1006543007727 Class I aldolases; Region: Aldolase_Class_I; cl17187 1006543007728 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 1006543007729 Helix-turn-helix domain; Region: HTH_28; pfam13518 1006543007730 Winged helix-turn helix; Region: HTH_29; pfam13551 1006543007731 Integrase core domain; Region: rve; pfam00665 1006543007732 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1006543007733 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1006543007734 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1006543007735 catalytic residues [active] 1006543007736 catalytic nucleophile [active] 1006543007737 Presynaptic Site I dimer interface [polypeptide binding]; other site 1006543007738 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1006543007739 Synaptic Flat tetramer interface [polypeptide binding]; other site 1006543007740 Synaptic Site I dimer interface [polypeptide binding]; other site 1006543007741 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1006543007742 DNA-binding interface [nucleotide binding]; DNA binding site 1006543007743 Predicted transcriptional regulator [Transcription]; Region: COG3682 1006543007744 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1006543007745 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1006543007746 Homeodomain-like domain; Region: HTH_32; pfam13565 1006543007747 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1006543007748 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1006543007749 Surface antigen [General function prediction only]; Region: COG3942 1006543007750 CHAP domain; Region: CHAP; pfam05257 1006543007751 ribonuclease E; Reviewed; Region: rne; PRK10811 1006543007752 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1006543007753 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1006543007754 AAA-like domain; Region: AAA_10; pfam12846 1006543007755 TcpE family; Region: TcpE; pfam12648 1006543007756 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1006543007757 Replication initiation factor; Region: Rep_trans; pfam02486 1006543007758 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1006543007759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 1006543007760 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1006543007761 Phosphotransferase enzyme family; Region: APH; pfam01636 1006543007762 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1006543007763 active site 1006543007764 ATP binding site [chemical binding]; other site 1006543007765 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1006543007766 active site 1006543007767 ATP binding site [chemical binding]; other site 1006543007768 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1006543007769 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1006543007770 quinone interaction residues [chemical binding]; other site 1006543007771 active site 1006543007772 catalytic residues [active] 1006543007773 FMN binding site [chemical binding]; other site 1006543007774 substrate binding site [chemical binding]; other site 1006543007775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1006543007776 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1006543007777 dimer interface [polypeptide binding]; other site 1006543007778 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1006543007779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1006543007780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1006543007781 Predicted acyl esterases [General function prediction only]; Region: COG2936 1006543007782 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1006543007783 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1006543007784 tetramerization interface [polypeptide binding]; other site 1006543007785 active site 1006543007786 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1006543007787 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1006543007788 active site 1006543007789 ATP-binding site [chemical binding]; other site 1006543007790 pantoate-binding site; other site 1006543007791 HXXH motif; other site 1006543007792 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1006543007793 oligomerization interface [polypeptide binding]; other site 1006543007794 active site 1006543007795 metal binding site [ion binding]; metal-binding site 1006543007796 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1006543007797 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1006543007798 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1006543007799 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1006543007800 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1006543007801 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1006543007802 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1006543007803 NAD binding site [chemical binding]; other site 1006543007804 dimer interface [polypeptide binding]; other site 1006543007805 substrate binding site [chemical binding]; other site 1006543007806 amino acid transporter; Region: 2A0306; TIGR00909 1006543007807 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1006543007808 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1006543007809 inhibitor-cofactor binding pocket; inhibition site 1006543007810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543007811 catalytic residue [active] 1006543007812 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1006543007813 catalytic residue [active] 1006543007814 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1006543007815 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1006543007816 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1006543007817 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1006543007818 acyl-activating enzyme (AAE) consensus motif; other site 1006543007819 AMP binding site [chemical binding]; other site 1006543007820 active site 1006543007821 CoA binding site [chemical binding]; other site 1006543007822 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1006543007823 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1006543007824 choline dehydrogenase; Validated; Region: PRK02106 1006543007825 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1006543007826 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1006543007827 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1006543007828 tetramerization interface [polypeptide binding]; other site 1006543007829 NAD(P) binding site [chemical binding]; other site 1006543007830 catalytic residues [active] 1006543007831 Predicted transcriptional regulators [Transcription]; Region: COG1510 1006543007832 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1006543007833 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1006543007834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1006543007835 FeS/SAM binding site; other site 1006543007836 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1006543007837 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1006543007838 effector binding site; other site 1006543007839 active site 1006543007840 Zn binding site [ion binding]; other site 1006543007841 glycine loop; other site 1006543007842 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1006543007843 Citrate transporter; Region: CitMHS; pfam03600 1006543007844 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1006543007845 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1006543007846 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1006543007847 Flavodoxin; Region: Flavodoxin_1; pfam00258 1006543007848 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1006543007849 FAD binding pocket [chemical binding]; other site 1006543007850 FAD binding motif [chemical binding]; other site 1006543007851 catalytic residues [active] 1006543007852 NAD binding pocket [chemical binding]; other site 1006543007853 phosphate binding motif [ion binding]; other site 1006543007854 beta-alpha-beta structure motif; other site 1006543007855 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1006543007856 catalytic residues [active] 1006543007857 dimer interface [polypeptide binding]; other site 1006543007858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1006543007859 Integrase core domain; Region: rve; pfam00665 1006543007860 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1006543007861 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1006543007862 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543007863 MULE transposase domain; Region: MULE; pfam10551 1006543007864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1006543007865 aminoglycoside resistance protein; Provisional; Region: PRK13746 1006543007866 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1006543007867 active site 1006543007868 NTP binding site [chemical binding]; other site 1006543007869 metal binding triad [ion binding]; metal-binding site 1006543007870 antibiotic binding site [chemical binding]; other site 1006543007871 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1006543007872 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1006543007873 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1006543007874 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1006543007875 active site 1006543007876 DNA binding site [nucleotide binding] 1006543007877 Int/Topo IB signature motif; other site 1006543007878 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1006543007879 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 1006543007880 Int/Topo IB signature motif; other site 1006543007881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1006543007882 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1006543007883 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 1006543007884 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1006543007885 MPN+ (JAMM) motif; other site 1006543007886 Zinc-binding site [ion binding]; other site 1006543007887 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1006543007888 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1006543007889 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1006543007890 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1006543007891 catalytic residues [active] 1006543007892 catalytic nucleophile [active] 1006543007893 Recombinase; Region: Recombinase; pfam07508 1006543007894 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1006543007895 Phage associated DNA primase [General function prediction only]; Region: COG3378 1006543007896 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1006543007897 active site 1006543007898 DNA binding site [nucleotide binding] 1006543007899 catalytic site [active] 1006543007900 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 1006543007901 GIY-YIG motif/motif A; other site 1006543007902 putative active site [active] 1006543007903 putative metal binding site [ion binding]; other site 1006543007904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1006543007905 Integrase core domain; Region: rve; pfam00665 1006543007906 FtsX-like permease family; Region: FtsX; pfam02687 1006543007907 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1006543007908 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1006543007909 Walker A/P-loop; other site 1006543007910 ATP binding site [chemical binding]; other site 1006543007911 Q-loop/lid; other site 1006543007912 ABC transporter signature motif; other site 1006543007913 Walker B; other site 1006543007914 D-loop; other site 1006543007915 H-loop/switch region; other site 1006543007916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1006543007917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1006543007918 ATP binding site [chemical binding]; other site 1006543007919 Mg2+ binding site [ion binding]; other site 1006543007920 G-X-G motif; other site 1006543007921 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1006543007922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1006543007923 active site 1006543007924 phosphorylation site [posttranslational modification] 1006543007925 intermolecular recognition site; other site 1006543007926 dimerization interface [polypeptide binding]; other site 1006543007927 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1006543007928 DNA binding site [nucleotide binding] 1006543007929 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1006543007930 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1006543007931 dimer interface [polypeptide binding]; other site 1006543007932 active site 1006543007933 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1006543007934 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1006543007935 MarR family; Region: MarR_2; pfam12802 1006543007936 Predicted esterase [General function prediction only]; Region: COG0627 1006543007937 S-formylglutathione hydrolase; Region: PLN02442 1006543007938 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1006543007939 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1006543007940 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1006543007941 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1006543007942 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1006543007943 ligand binding site [chemical binding]; other site 1006543007944 flexible hinge region; other site 1006543007945 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1006543007946 carbamate kinase; Reviewed; Region: PRK12686 1006543007947 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1006543007948 putative substrate binding site [chemical binding]; other site 1006543007949 nucleotide binding site [chemical binding]; other site 1006543007950 nucleotide binding site [chemical binding]; other site 1006543007951 homodimer interface [polypeptide binding]; other site 1006543007952 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1006543007953 ornithine carbamoyltransferase; Validated; Region: PRK02102 1006543007954 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1006543007955 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1006543007956 arginine deiminase; Provisional; Region: PRK01388 1006543007957 Arginine repressor [Transcription]; Region: ArgR; COG1438 1006543007958 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1006543007959 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1006543007960 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1006543007961 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1006543007962 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1006543007963 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1006543007964 active site 1006543007965 Zn binding site [ion binding]; other site 1006543007966 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1006543007967 HTH domain; Region: HTH_11; pfam08279 1006543007968 PRD domain; Region: PRD; pfam00874 1006543007969 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1006543007970 active site 1006543007971 P-loop; other site 1006543007972 phosphorylation site [posttranslational modification] 1006543007973 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1006543007974 active site 1006543007975 phosphorylation site [posttranslational modification] 1006543007976 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1006543007977 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1006543007978 active site 1006543007979 P-loop; other site 1006543007980 phosphorylation site [posttranslational modification] 1006543007981 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1006543007982 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1006543007983 active site 1006543007984 phosphorylation site [posttranslational modification] 1006543007985 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1006543007986 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1006543007987 Predicted membrane protein [Function unknown]; Region: COG1511 1006543007988 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1006543007989 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1006543007990 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1006543007991 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1006543007992 CHAP domain; Region: CHAP; pfam05257 1006543007993 Isochorismatase family; Region: Isochorismatase; pfam00857 1006543007994 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1006543007995 catalytic triad [active] 1006543007996 conserved cis-peptide bond; other site 1006543007997 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1006543007998 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1006543007999 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1006543008000 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1006543008001 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1006543008002 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1006543008003 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1006543008004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1006543008005 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1006543008006 SecY translocase; Region: SecY; pfam00344 1006543008007 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1006543008008 legume lectins; Region: lectin_L-type; cd01951 1006543008009 homotetramer interaction site [polypeptide binding]; other site 1006543008010 carbohydrate binding site [chemical binding]; other site 1006543008011 metal binding site [ion binding]; metal-binding site 1006543008012 Putative Ig domain; Region: He_PIG; pfam05345 1006543008013 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1006543008014 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1006543008015 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1006543008016 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1006543008017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1006543008018 Coenzyme A binding pocket [chemical binding]; other site 1006543008019 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1006543008020 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1006543008021 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1006543008022 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1006543008023 Chain length determinant protein; Region: Wzz; cl15801 1006543008024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1006543008025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1006543008026 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1006543008027 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1006543008028 DXD motif; other site 1006543008029 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 1006543008030 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1006543008031 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1006543008032 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1006543008033 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1006543008034 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1006543008035 MULE transposase domain; Region: MULE; pfam10551 1006543008036 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1006543008037 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1006543008038 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1006543008039 metal binding site [ion binding]; metal-binding site 1006543008040 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1006543008041 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1006543008042 substrate binding site [chemical binding]; other site 1006543008043 glutamase interaction surface [polypeptide binding]; other site 1006543008044 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1006543008045 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1006543008046 catalytic residues [active] 1006543008047 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1006543008048 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1006543008049 putative active site [active] 1006543008050 oxyanion strand; other site 1006543008051 catalytic triad [active] 1006543008052 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1006543008053 putative active site pocket [active] 1006543008054 4-fold oligomerization interface [polypeptide binding]; other site 1006543008055 metal binding residues [ion binding]; metal-binding site 1006543008056 3-fold/trimer interface [polypeptide binding]; other site 1006543008057 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1006543008058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1006543008059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1006543008060 homodimer interface [polypeptide binding]; other site 1006543008061 catalytic residue [active] 1006543008062 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1006543008063 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1006543008064 NAD binding site [chemical binding]; other site 1006543008065 dimerization interface [polypeptide binding]; other site 1006543008066 product binding site; other site 1006543008067 substrate binding site [chemical binding]; other site 1006543008068 zinc binding site [ion binding]; other site 1006543008069 catalytic residues [active] 1006543008070 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 1006543008071 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1006543008072 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1006543008073 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1006543008074 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1006543008075 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1006543008076 putative active site [active] 1006543008077 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1006543008078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1006543008079 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1006543008080 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1006543008081 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1006543008082 Walker A/P-loop; other site 1006543008083 ATP binding site [chemical binding]; other site 1006543008084 Q-loop/lid; other site 1006543008085 ABC transporter signature motif; other site 1006543008086 Walker B; other site 1006543008087 D-loop; other site 1006543008088 H-loop/switch region; other site 1006543008089 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1006543008090 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1006543008091 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1006543008092 Walker A/P-loop; other site 1006543008093 ATP binding site [chemical binding]; other site 1006543008094 Q-loop/lid; other site 1006543008095 ABC transporter signature motif; other site 1006543008096 Walker B; other site 1006543008097 D-loop; other site 1006543008098 H-loop/switch region; other site 1006543008099 hypothetical protein; Provisional; Region: PRK13661 1006543008100 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1006543008101 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1006543008102 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1006543008103 Strictosidine synthase; Region: Str_synth; pfam03088 1006543008104 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1006543008105 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1006543008106 active site residue [active] 1006543008107 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1006543008108 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1006543008109 putative substrate binding pocket [chemical binding]; other site 1006543008110 AC domain interface; other site 1006543008111 catalytic triad [active] 1006543008112 AB domain interface; other site 1006543008113 interchain disulfide; other site 1006543008114 DinB superfamily; Region: DinB_2; pfam12867 1006543008115 Collagen binding domain; Region: Collagen_bind; pfam05737 1006543008116 Cna protein B-type domain; Region: Cna_B; pfam05738 1006543008117 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1006543008118 domain interaction interfaces [polypeptide binding]; other site 1006543008119 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1006543008120 domain interaction interfaces [polypeptide binding]; other site 1006543008121 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1006543008122 domain interaction interfaces [polypeptide binding]; other site 1006543008123 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1006543008124 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1006543008125 transmembrane helices; other site 1006543008126 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1006543008127 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1006543008128 hypothetical protein; Provisional; Region: PRK07758 1006543008129 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1006543008130 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1006543008131 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1006543008132 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1006543008133 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1006543008134 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1006543008135 Walker A/P-loop; other site 1006543008136 ATP binding site [chemical binding]; other site 1006543008137 Q-loop/lid; other site 1006543008138 ABC transporter signature motif; other site 1006543008139 Walker B; other site 1006543008140 D-loop; other site 1006543008141 H-loop/switch region; other site 1006543008142 FtsX-like permease family; Region: FtsX; pfam02687 1006543008143 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1006543008144 Integrase core domain; Region: rve; pfam00665 1006543008145 Integrase core domain; Region: rve_3; cl15866 1006543008146 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1006543008147 active site 1006543008148 catalytic residues [active] 1006543008149 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1006543008150 DNA-binding site [nucleotide binding]; DNA binding site 1006543008151 RNA-binding motif; other site 1006543008152 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1006543008153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1006543008154 non-specific DNA binding site [nucleotide binding]; other site 1006543008155 salt bridge; other site 1006543008156 sequence-specific DNA binding site [nucleotide binding]; other site 1006543008157 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1006543008158 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1006543008159 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1006543008160 ParB-like nuclease domain; Region: ParBc; pfam02195 1006543008161 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1006543008162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1006543008163 S-adenosylmethionine binding site [chemical binding]; other site 1006543008164 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1006543008165 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1006543008166 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1006543008167 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1006543008168 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1006543008169 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1006543008170 G1 box; other site 1006543008171 GTP/Mg2+ binding site [chemical binding]; other site 1006543008172 Switch I region; other site 1006543008173 G2 box; other site 1006543008174 Switch II region; other site 1006543008175 G3 box; other site 1006543008176 G4 box; other site 1006543008177 G5 box; other site 1006543008178 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1006543008179 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1006543008180 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399