-- dump date   	20140620_075225
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
548473000001	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
548473000002	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
548473000003	dimer interface [polypeptide binding]; other site
548473000004	putative anticodon binding site; other site
548473000005	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
548473000006	motif 1; other site
548473000007	active site
548473000008	motif 2; other site
548473000009	motif 3; other site
548473000010	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
548473000011	catalytic center binding site [active]
548473000012	ATP binding site [chemical binding]; other site
548473000013	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
548473000014	homooctamer interface [polypeptide binding]; other site
548473000015	active site
548473000016	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
548473000017	dihydropteroate synthase; Region: DHPS; TIGR01496
548473000018	substrate binding pocket [chemical binding]; other site
548473000019	dimer interface [polypeptide binding]; other site
548473000020	inhibitor binding site; inhibition site
548473000021	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
548473000022	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
548473000023	dimer interface [polypeptide binding]; other site
548473000024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473000025	catalytic residue [active]
548473000026	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
548473000027	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
548473000028	dimerization interface [polypeptide binding]; other site
548473000029	domain crossover interface; other site
548473000030	redox-dependent activation switch; other site
548473000031	FtsH Extracellular; Region: FtsH_ext; pfam06480
548473000032	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
548473000033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473000034	Walker A motif; other site
548473000035	ATP binding site [chemical binding]; other site
548473000036	Walker B motif; other site
548473000037	arginine finger; other site
548473000038	Peptidase family M41; Region: Peptidase_M41; pfam01434
548473000039	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
548473000040	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548473000041	active site
548473000042	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
548473000043	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
548473000044	Ligand Binding Site [chemical binding]; other site
548473000045	TilS substrate C-terminal domain; Region: TilS_C; smart00977
548473000046	hypothetical protein; Provisional; Region: PRK08582
548473000047	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
548473000048	RNA binding site [nucleotide binding]; other site
548473000049	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
548473000050	Septum formation initiator; Region: DivIC; pfam04977
548473000051	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548473000052	RNA binding surface [nucleotide binding]; other site
548473000053	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
548473000054	putative SAM binding site [chemical binding]; other site
548473000055	putative homodimer interface [polypeptide binding]; other site
548473000056	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
548473000057	homodimer interface [polypeptide binding]; other site
548473000058	metal binding site [ion binding]; metal-binding site
548473000059	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
548473000060	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
548473000061	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
548473000062	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
548473000063	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473000064	ATP binding site [chemical binding]; other site
548473000065	putative Mg++ binding site [ion binding]; other site
548473000066	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548473000067	nucleotide binding region [chemical binding]; other site
548473000068	ATP-binding site [chemical binding]; other site
548473000069	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
548473000070	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
548473000071	putative active site [active]
548473000072	catalytic residue [active]
548473000073	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
548473000074	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
548473000075	5S rRNA interface [nucleotide binding]; other site
548473000076	CTC domain interface [polypeptide binding]; other site
548473000077	L16 interface [polypeptide binding]; other site
548473000078	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
548473000079	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
548473000080	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548473000081	active site
548473000082	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
548473000083	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
548473000084	Substrate binding site; other site
548473000085	Mg++ binding site; other site
548473000086	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
548473000087	active site
548473000088	substrate binding site [chemical binding]; other site
548473000089	CoA binding site [chemical binding]; other site
548473000090	regulatory protein SpoVG; Reviewed; Region: PRK13259
548473000091	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
548473000092	homotrimer interaction site [polypeptide binding]; other site
548473000093	putative active site [active]
548473000094	pur operon repressor; Provisional; Region: PRK09213
548473000095	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
548473000096	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548473000097	active site
548473000098	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
548473000099	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
548473000100	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
548473000101	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
548473000102	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
548473000103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473000104	S-adenosylmethionine binding site [chemical binding]; other site
548473000105	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
548473000106	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
548473000107	putative active site [active]
548473000108	putative metal binding site [ion binding]; other site
548473000109	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
548473000110	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
548473000111	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
548473000112	active site
548473000113	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
548473000114	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
548473000115	active site
548473000116	HIGH motif; other site
548473000117	KMSKS motif; other site
548473000118	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
548473000119	tRNA binding surface [nucleotide binding]; other site
548473000120	anticodon binding site; other site
548473000121	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
548473000122	dimer interface [polypeptide binding]; other site
548473000123	putative tRNA-binding site [nucleotide binding]; other site
548473000124	Predicted methyltransferases [General function prediction only]; Region: COG0313
548473000125	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
548473000126	putative SAM binding site [chemical binding]; other site
548473000127	putative homodimer interface [polypeptide binding]; other site
548473000128	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
548473000129	GIY-YIG motif/motif A; other site
548473000130	putative active site [active]
548473000131	putative metal binding site [ion binding]; other site
548473000132	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
548473000133	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473000134	S-adenosylmethionine binding site [chemical binding]; other site
548473000135	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
548473000136	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
548473000137	DNA polymerase III subunit delta'; Validated; Region: PRK08058
548473000138	DNA polymerase III subunit delta'; Validated; Region: PRK08485
548473000139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
548473000140	thymidylate kinase; Validated; Region: tmk; PRK00698
548473000141	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
548473000142	TMP-binding site; other site
548473000143	ATP-binding site [chemical binding]; other site
548473000144	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
548473000145	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
548473000146	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548473000147	catalytic residue [active]
548473000148	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
548473000149	recombination protein RecR; Reviewed; Region: recR; PRK00076
548473000150	RecR protein; Region: RecR; pfam02132
548473000151	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
548473000152	putative active site [active]
548473000153	putative metal-binding site [ion binding]; other site
548473000154	tetramer interface [polypeptide binding]; other site
548473000155	hypothetical protein; Validated; Region: PRK00153
548473000156	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
548473000157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473000158	Walker A motif; other site
548473000159	ATP binding site [chemical binding]; other site
548473000160	Walker B motif; other site
548473000161	arginine finger; other site
548473000162	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
548473000163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473000164	Coenzyme A binding pocket [chemical binding]; other site
548473000165	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548473000166	DNA-binding site [nucleotide binding]; DNA binding site
548473000167	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
548473000168	UTRA domain; Region: UTRA; pfam07702
548473000169	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
548473000170	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
548473000171	Ca binding site [ion binding]; other site
548473000172	active site
548473000173	catalytic site [active]
548473000174	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
548473000175	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
548473000176	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548473000177	active site turn [active]
548473000178	phosphorylation site [posttranslational modification]
548473000179	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548473000180	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
548473000181	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548473000182	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
548473000183	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
548473000184	active site
548473000185	dimer interface [polypeptide binding]; other site
548473000186	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
548473000187	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
548473000188	active site
548473000189	FMN binding site [chemical binding]; other site
548473000190	substrate binding site [chemical binding]; other site
548473000191	3Fe-4S cluster binding site [ion binding]; other site
548473000192	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
548473000193	domain interface; other site
548473000194	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548473000195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548473000196	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
548473000197	dimerization interface [polypeptide binding]; other site
548473000198	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
548473000199	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
548473000200	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473000201	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
548473000202	Coenzyme A binding pocket [chemical binding]; other site
548473000203	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
548473000204	nudix motif; other site
548473000205	LysM domain; Region: LysM; pfam01476
548473000206	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
548473000207	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
548473000208	Surface antigen [General function prediction only]; Region: COG3942
548473000209	CHAP domain; Region: CHAP; pfam05257
548473000210	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
548473000211	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
548473000212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473000213	dimer interface [polypeptide binding]; other site
548473000214	conserved gate region; other site
548473000215	ABC-ATPase subunit interface; other site
548473000216	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
548473000217	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
548473000218	Walker A/P-loop; other site
548473000219	ATP binding site [chemical binding]; other site
548473000220	Q-loop/lid; other site
548473000221	ABC transporter signature motif; other site
548473000222	Walker B; other site
548473000223	D-loop; other site
548473000224	H-loop/switch region; other site
548473000225	NIL domain; Region: NIL; pfam09383
548473000226	cystathionine beta-lyase; Provisional; Region: PRK07671
548473000227	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
548473000228	homodimer interface [polypeptide binding]; other site
548473000229	substrate-cofactor binding pocket; other site
548473000230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473000231	catalytic residue [active]
548473000232	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
548473000233	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
548473000234	dimer interface [polypeptide binding]; other site
548473000235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473000236	catalytic residue [active]
548473000237	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
548473000238	Na2 binding site [ion binding]; other site
548473000239	putative substrate binding site 1 [chemical binding]; other site
548473000240	Na binding site 1 [ion binding]; other site
548473000241	putative substrate binding site 2 [chemical binding]; other site
548473000242	Esterase/lipase [General function prediction only]; Region: COG1647
548473000243	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
548473000244	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
548473000245	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
548473000246	active site
548473000247	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
548473000248	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
548473000249	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
548473000250	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
548473000251	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
548473000252	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
548473000253	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
548473000254	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
548473000255	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
548473000256	Protein of unknown function, DUF576; Region: DUF576; pfam04507
548473000257	Protein of unknown function, DUF576; Region: DUF576; pfam04507
548473000258	Protein of unknown function, DUF576; Region: DUF576; pfam04507
548473000259	Protein of unknown function, DUF576; Region: DUF576; pfam04507
548473000260	Protein of unknown function, DUF576; Region: DUF576; pfam04507
548473000261	superantigen-like protein; Reviewed; Region: PRK13036
548473000262	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
548473000263	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473000264	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
548473000265	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
548473000266	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
548473000267	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
548473000268	HsdM N-terminal domain; Region: HsdM_N; pfam12161
548473000269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473000270	S-adenosylmethionine binding site [chemical binding]; other site
548473000271	superantigen-like protein; Reviewed; Region: PRK13038
548473000272	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
548473000273	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473000274	superantigen-like protein; Reviewed; Region: PRK13345
548473000275	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
548473000276	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473000277	superantigen-like protein 7; Reviewed; Region: PRK13346
548473000278	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
548473000279	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473000280	superantigen-like protein 5; Reviewed; Region: PRK13035
548473000281	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
548473000282	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473000283	superantigen-like protein 7; Reviewed; Region: PRK13346
548473000284	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
548473000285	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473000286	superantigen-like protein; Reviewed; Region: PRK13335
548473000287	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
548473000288	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473000289	superantigen-like protein; Reviewed; Region: PRK13041
548473000290	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
548473000291	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473000292	superantigen-like protein; Reviewed; Region: PRK13037
548473000293	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
548473000294	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473000295	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
548473000296	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
548473000297	NADP binding site [chemical binding]; other site
548473000298	Predicted membrane protein [Function unknown]; Region: COG3759
548473000299	PemK-like protein; Region: PemK; pfam02452
548473000300	GMP synthase; Reviewed; Region: guaA; PRK00074
548473000301	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
548473000302	AMP/PPi binding site [chemical binding]; other site
548473000303	candidate oxyanion hole; other site
548473000304	catalytic triad [active]
548473000305	potential glutamine specificity residues [chemical binding]; other site
548473000306	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
548473000307	ATP Binding subdomain [chemical binding]; other site
548473000308	Ligand Binding sites [chemical binding]; other site
548473000309	Dimerization subdomain; other site
548473000310	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
548473000311	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
548473000312	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
548473000313	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
548473000314	active site
548473000315	xanthine permease; Region: pbuX; TIGR03173
548473000316	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548473000317	active site
548473000318	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
548473000319	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
548473000320	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
548473000321	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
548473000322	dimer interface [polypeptide binding]; other site
548473000323	FMN binding site [chemical binding]; other site
548473000324	NADPH bind site [chemical binding]; other site
548473000325	peroxiredoxin; Region: AhpC; TIGR03137
548473000326	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
548473000327	dimer interface [polypeptide binding]; other site
548473000328	decamer (pentamer of dimers) interface [polypeptide binding]; other site
548473000329	catalytic triad [active]
548473000330	peroxidatic and resolving cysteines [active]
548473000331	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
548473000332	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
548473000333	catalytic residue [active]
548473000334	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
548473000335	catalytic residues [active]
548473000336	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548473000337	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473000338	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548473000339	catalytic core [active]
548473000340	Predicted membrane protein [Function unknown]; Region: COG2261
548473000341	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473000342	non-specific DNA binding site [nucleotide binding]; other site
548473000343	salt bridge; other site
548473000344	sequence-specific DNA binding site [nucleotide binding]; other site
548473000345	Predicted membrane protein [Function unknown]; Region: COG3212
548473000346	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
548473000347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
548473000348	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
548473000349	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
548473000350	active site
548473000351	Int/Topo IB signature motif; other site
548473000352	Abi-like protein; Region: Abi_2; pfam07751
548473000353	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
548473000354	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
548473000355	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
548473000356	dimer interface [polypeptide binding]; other site
548473000357	ssDNA binding site [nucleotide binding]; other site
548473000358	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548473000359	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
548473000360	GTP-binding protein YchF; Reviewed; Region: PRK09601
548473000361	YchF GTPase; Region: YchF; cd01900
548473000362	G1 box; other site
548473000363	GTP/Mg2+ binding site [chemical binding]; other site
548473000364	Switch I region; other site
548473000365	G2 box; other site
548473000366	Switch II region; other site
548473000367	G3 box; other site
548473000368	G4 box; other site
548473000369	G5 box; other site
548473000370	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
548473000371	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
548473000372	Mechanosensitive ion channel; Region: MS_channel; pfam00924
548473000373	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
548473000374	ParB-like nuclease domain; Region: ParB; smart00470
548473000375	T-box leader; HMPREF0772_nc10005
548473000376	cystathionine gamma-synthase; Reviewed; Region: PRK08247
548473000377	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
548473000378	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548473000379	catalytic residue [active]
548473000380	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
548473000381	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
548473000382	homodimer interface [polypeptide binding]; other site
548473000383	substrate-cofactor binding pocket; other site
548473000384	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473000385	catalytic residue [active]
548473000386	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
548473000387	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
548473000388	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
548473000389	FAD binding site [chemical binding]; other site
548473000390	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
548473000391	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
548473000392	THF binding site; other site
548473000393	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
548473000394	substrate binding site [chemical binding]; other site
548473000395	THF binding site; other site
548473000396	zinc-binding site [ion binding]; other site
548473000397	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
548473000398	putative acyltransferase; Provisional; Region: PRK05790
548473000399	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
548473000400	dimer interface [polypeptide binding]; other site
548473000401	active site
548473000402	Predicted membrane protein [Function unknown]; Region: COG4292
548473000403	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
548473000404	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
548473000405	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
548473000406	Walker A/P-loop; other site
548473000407	ATP binding site [chemical binding]; other site
548473000408	Q-loop/lid; other site
548473000409	ABC transporter signature motif; other site
548473000410	Walker B; other site
548473000411	D-loop; other site
548473000412	H-loop/switch region; other site
548473000413	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
548473000414	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473000415	non-specific DNA binding site [nucleotide binding]; other site
548473000416	salt bridge; other site
548473000417	sequence-specific DNA binding site [nucleotide binding]; other site
548473000418	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
548473000419	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
548473000420	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
548473000421	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
548473000422	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
548473000423	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
548473000424	Imelysin; Region: Peptidase_M75; pfam09375
548473000425	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
548473000426	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548473000427	Predicted membrane protein [Function unknown]; Region: COG2855
548473000428	Predicted flavoprotein [General function prediction only]; Region: COG0431
548473000429	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
548473000430	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
548473000431	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
548473000432	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
548473000433	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
548473000434	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
548473000435	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
548473000436	Zn binding site [ion binding]; other site
548473000437	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
548473000438	Zn binding site [ion binding]; other site
548473000439	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
548473000440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473000441	putative substrate translocation pore; other site
548473000442	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473000443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
548473000444	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
548473000445	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
548473000446	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
548473000447	MarR family; Region: MarR_2; pfam12802
548473000448	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
548473000449	HTH domain; Region: HTH_11; pfam08279
548473000450	HTH domain; Region: HTH_11; pfam08279
548473000451	PRD domain; Region: PRD; pfam00874
548473000452	PRD domain; Region: PRD; pfam00874
548473000453	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
548473000454	active site
548473000455	P-loop; other site
548473000456	phosphorylation site [posttranslational modification]
548473000457	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548473000458	active site
548473000459	phosphorylation site [posttranslational modification]
548473000460	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548473000461	active site
548473000462	phosphorylation site [posttranslational modification]
548473000463	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
548473000464	active site
548473000465	P-loop; other site
548473000466	phosphorylation site [posttranslational modification]
548473000467	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
548473000468	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
548473000469	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
548473000470	NADP binding site [chemical binding]; other site
548473000471	putative substrate binding site [chemical binding]; other site
548473000472	active site
548473000473	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
548473000474	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
548473000475	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
548473000476	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
548473000477	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
548473000478	Replication protein C N-terminal domain; Region: RP-C; pfam03428
548473000479	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
548473000480	putative ADP-ribose binding site [chemical binding]; other site
548473000481	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
548473000482	lipoyl attachment site [posttranslational modification]; other site
548473000483	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
548473000484	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
548473000485	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
548473000486	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
548473000487	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
548473000488	putative active site [active]
548473000489	putative FMN binding site [chemical binding]; other site
548473000490	putative substrate binding site [chemical binding]; other site
548473000491	putative catalytic residue [active]
548473000492	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
548473000493	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
548473000494	PGAP1-like protein; Region: PGAP1; pfam07819
548473000495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
548473000496	Nucleoside recognition; Region: Gate; pfam07670
548473000497	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
548473000498	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
548473000499	putative active site cavity [active]
548473000500	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
548473000501	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
548473000502	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
548473000503	putative active site [active]
548473000504	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
548473000505	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
548473000506	nucleotide binding site [chemical binding]; other site
548473000507	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
548473000508	N-acetylneuraminate lyase; Provisional; Region: PRK04147
548473000509	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
548473000510	inhibitor site; inhibition site
548473000511	active site
548473000512	dimer interface [polypeptide binding]; other site
548473000513	catalytic residue [active]
548473000514	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
548473000515	putative transporter; Provisional; Region: PRK10484
548473000516	Na binding site [ion binding]; other site
548473000517	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
548473000518	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
548473000519	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
548473000520	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
548473000521	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473000522	non-specific DNA binding site [nucleotide binding]; other site
548473000523	salt bridge; other site
548473000524	sequence-specific DNA binding site [nucleotide binding]; other site
548473000525	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
548473000526	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
548473000527	substrate binding site [chemical binding]; other site
548473000528	ATP binding site [chemical binding]; other site
548473000529	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
548473000530	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
548473000531	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548473000532	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548473000533	Walker A/P-loop; other site
548473000534	ATP binding site [chemical binding]; other site
548473000535	Q-loop/lid; other site
548473000536	ABC transporter signature motif; other site
548473000537	Walker B; other site
548473000538	D-loop; other site
548473000539	H-loop/switch region; other site
548473000540	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
548473000541	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
548473000542	FtsX-like permease family; Region: FtsX; pfam02687
548473000543	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
548473000544	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
548473000545	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
548473000546	Protein of unknown function, DUF600; Region: DUF600; cl04640
548473000547	Protein of unknown function, DUF600; Region: DUF600; cl04640
548473000548	Protein of unknown function, DUF600; Region: DUF600; cl04640
548473000549	conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741
548473000550	Protein of unknown function, DUF600; Region: DUF600; cl04640
548473000551	Protein of unknown function, DUF600; Region: DUF600; cl04640
548473000552	Protein of unknown function, DUF600; Region: DUF600; cl04640
548473000553	LXG domain of WXG superfamily; Region: LXG; pfam04740
548473000554	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
548473000555	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
548473000556	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
548473000557	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
548473000558	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
548473000559	Predicted membrane protein [Function unknown]; Region: COG4499
548473000560	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
548473000561	Uncharacterized small protein [Function unknown]; Region: COG5417
548473000562	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
548473000563	Predicted membrane protein [Function unknown]; Region: COG1511
548473000564	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
548473000565	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
548473000566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
548473000567	Surface antigen [General function prediction only]; Region: COG3942
548473000568	CHAP domain; Region: CHAP; pfam05257
548473000569	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
548473000570	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
548473000571	Walker A/P-loop; other site
548473000572	ATP binding site [chemical binding]; other site
548473000573	Q-loop/lid; other site
548473000574	ABC transporter signature motif; other site
548473000575	Walker B; other site
548473000576	D-loop; other site
548473000577	H-loop/switch region; other site
548473000578	Surface antigen [General function prediction only]; Region: COG3942
548473000579	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
548473000580	Peptidase family M23; Region: Peptidase_M23; pfam01551
548473000581	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
548473000582	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
548473000583	active site
548473000584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473000585	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473000586	Transcriptional regulators [Transcription]; Region: PurR; COG1609
548473000587	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
548473000588	DNA binding site [nucleotide binding]
548473000589	domain linker motif; other site
548473000590	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
548473000591	dimerization interface [polypeptide binding]; other site
548473000592	ligand binding site [chemical binding]; other site
548473000593	Sugar transport protein; Region: Sugar_transport; pfam06800
548473000594	D-ribose pyranase; Provisional; Region: PRK11797
548473000595	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
548473000596	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
548473000597	substrate binding site [chemical binding]; other site
548473000598	dimer interface [polypeptide binding]; other site
548473000599	ATP binding site [chemical binding]; other site
548473000600	Methyltransferase domain; Region: Methyltransf_31; pfam13847
548473000601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473000602	S-adenosylmethionine binding site [chemical binding]; other site
548473000603	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
548473000604	beta-galactosidase; Region: BGL; TIGR03356
548473000605	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
548473000606	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
548473000607	HPr interaction site; other site
548473000608	glycerol kinase (GK) interaction site [polypeptide binding]; other site
548473000609	active site
548473000610	phosphorylation site [posttranslational modification]
548473000611	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
548473000612	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548473000613	DNA-binding site [nucleotide binding]; DNA binding site
548473000614	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
548473000615	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
548473000616	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
548473000617	antiholin-like protein LrgB; Provisional; Region: PRK04288
548473000618	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
548473000619	two-component response regulator; Provisional; Region: PRK14084
548473000620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473000621	active site
548473000622	phosphorylation site [posttranslational modification]
548473000623	intermolecular recognition site; other site
548473000624	dimerization interface [polypeptide binding]; other site
548473000625	LytTr DNA-binding domain; Region: LytTR; pfam04397
548473000626	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
548473000627	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
548473000628	Histidine kinase; Region: His_kinase; pfam06580
548473000629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473000630	Mg2+ binding site [ion binding]; other site
548473000631	G-X-G motif; other site
548473000632	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
548473000633	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
548473000634	Hemerythrin-like domain; Region: Hr-like; cd12108
548473000635	Fe binding site [ion binding]; other site
548473000636	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
548473000637	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
548473000638	active site
548473000639	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
548473000640	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
548473000641	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
548473000642	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
548473000643	putative NAD(P) binding site [chemical binding]; other site
548473000644	putative catalytic Zn binding site [ion binding]; other site
548473000645	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
548473000646	substrate binding site; other site
548473000647	dimer interface; other site
548473000648	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
548473000649	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
548473000650	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
548473000651	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
548473000652	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
548473000653	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
548473000654	putative NAD(P) binding site [chemical binding]; other site
548473000655	putative catalytic Zn binding site [ion binding]; other site
548473000656	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
548473000657	substrate binding site; other site
548473000658	dimer interface; other site
548473000659	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
548473000660	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
548473000661	putative NAD(P) binding site [chemical binding]; other site
548473000662	catalytic Zn binding site [ion binding]; other site
548473000663	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
548473000664	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
548473000665	putative NAD(P) binding site [chemical binding]; other site
548473000666	catalytic Zn binding site [ion binding]; other site
548473000667	structural Zn binding site [ion binding]; other site
548473000668	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
548473000669	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
548473000670	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
548473000671	active site
548473000672	P-loop; other site
548473000673	phosphorylation site [posttranslational modification]
548473000674	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548473000675	active site
548473000676	phosphorylation site [posttranslational modification]
548473000677	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
548473000678	Mga helix-turn-helix domain; Region: Mga; pfam05043
548473000679	PRD domain; Region: PRD; pfam00874
548473000680	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
548473000681	active site
548473000682	P-loop; other site
548473000683	phosphorylation site [posttranslational modification]
548473000684	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548473000685	active site
548473000686	phosphorylation site [posttranslational modification]
548473000687	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
548473000688	active site
548473000689	tetramer interface [polypeptide binding]; other site
548473000690	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
548473000691	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548473000692	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548473000693	active site turn [active]
548473000694	phosphorylation site [posttranslational modification]
548473000695	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
548473000696	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
548473000697	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548473000698	NAD binding site [chemical binding]; other site
548473000699	dimer interface [polypeptide binding]; other site
548473000700	substrate binding site [chemical binding]; other site
548473000701	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
548473000702	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
548473000703	heme-binding site [chemical binding]; other site
548473000704	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
548473000705	FAD binding pocket [chemical binding]; other site
548473000706	FAD binding motif [chemical binding]; other site
548473000707	phosphate binding motif [ion binding]; other site
548473000708	beta-alpha-beta structure motif; other site
548473000709	NAD binding pocket [chemical binding]; other site
548473000710	Heme binding  pocket [chemical binding]; other site
548473000711	Uncharacterized conserved protein [Function unknown]; Region: COG3189
548473000712	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
548473000713	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
548473000714	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
548473000715	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
548473000716	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
548473000717	catalytic triad [active]
548473000718	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
548473000719	Coenzyme A transferase; Region: CoA_trans; smart00882
548473000720	Coenzyme A transferase; Region: CoA_trans; cl17247
548473000721	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
548473000722	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548473000723	acyl-activating enzyme (AAE) consensus motif; other site
548473000724	AMP binding site [chemical binding]; other site
548473000725	active site
548473000726	CoA binding site [chemical binding]; other site
548473000727	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
548473000728	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
548473000729	active site
548473000730	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
548473000731	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
548473000732	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
548473000733	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
548473000734	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
548473000735	substrate binding site [chemical binding]; other site
548473000736	oxyanion hole (OAH) forming residues; other site
548473000737	trimer interface [polypeptide binding]; other site
548473000738	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
548473000739	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
548473000740	dimer interface [polypeptide binding]; other site
548473000741	active site
548473000742	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
548473000743	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
548473000744	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
548473000745	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
548473000746	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
548473000747	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
548473000748	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
548473000749	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
548473000750	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
548473000751	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
548473000752	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
548473000753	putative active site [active]
548473000754	catalytic site [active]
548473000755	putative metal binding site [ion binding]; other site
548473000756	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
548473000757	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473000758	FeS/SAM binding site; other site
548473000759	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
548473000760	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
548473000761	Pyruvate formate lyase 1; Region: PFL1; cd01678
548473000762	coenzyme A binding site [chemical binding]; other site
548473000763	active site
548473000764	catalytic residues [active]
548473000765	glycine loop; other site
548473000766	potential frameshift: common BLAST hit: gi|49484823|ref|YP_042047.1| transposase
548473000767	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473000768	Integrase core domain; Region: rve; pfam00665
548473000769	Helix-turn-helix domain; Region: HTH_38; pfam13936
548473000770	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
548473000771	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
548473000772	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
548473000773	Histidine kinase; Region: His_kinase; pfam06580
548473000774	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473000775	ATP binding site [chemical binding]; other site
548473000776	Mg2+ binding site [ion binding]; other site
548473000777	G-X-G motif; other site
548473000778	Response regulator receiver domain; Region: Response_reg; pfam00072
548473000779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473000780	active site
548473000781	phosphorylation site [posttranslational modification]
548473000782	intermolecular recognition site; other site
548473000783	dimerization interface [polypeptide binding]; other site
548473000784	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
548473000785	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
548473000786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
548473000787	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
548473000788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473000789	putative substrate translocation pore; other site
548473000790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
548473000791	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
548473000792	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
548473000793	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
548473000794	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
548473000795	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
548473000796	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
548473000797	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
548473000798	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
548473000799	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
548473000800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473000801	dimer interface [polypeptide binding]; other site
548473000802	conserved gate region; other site
548473000803	putative PBP binding loops; other site
548473000804	ABC-ATPase subunit interface; other site
548473000805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473000806	dimer interface [polypeptide binding]; other site
548473000807	conserved gate region; other site
548473000808	ABC-ATPase subunit interface; other site
548473000809	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
548473000810	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
548473000811	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
548473000812	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
548473000813	Walker A/P-loop; other site
548473000814	ATP binding site [chemical binding]; other site
548473000815	Q-loop/lid; other site
548473000816	ABC transporter signature motif; other site
548473000817	Walker B; other site
548473000818	D-loop; other site
548473000819	H-loop/switch region; other site
548473000820	TOBE domain; Region: TOBE; pfam03459
548473000821	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
548473000822	Peptidase family M23; Region: Peptidase_M23; pfam01551
548473000823	azoreductase; Reviewed; Region: PRK00170
548473000824	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
548473000825	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
548473000826	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
548473000827	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
548473000828	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
548473000829	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
548473000830	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
548473000831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473000832	dimer interface [polypeptide binding]; other site
548473000833	conserved gate region; other site
548473000834	ABC-ATPase subunit interface; other site
548473000835	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
548473000836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473000837	dimer interface [polypeptide binding]; other site
548473000838	conserved gate region; other site
548473000839	putative PBP binding loops; other site
548473000840	ABC-ATPase subunit interface; other site
548473000841	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
548473000842	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473000843	Walker A/P-loop; other site
548473000844	ATP binding site [chemical binding]; other site
548473000845	Q-loop/lid; other site
548473000846	ABC transporter signature motif; other site
548473000847	Walker B; other site
548473000848	D-loop; other site
548473000849	H-loop/switch region; other site
548473000850	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
548473000851	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473000852	Walker A/P-loop; other site
548473000853	ATP binding site [chemical binding]; other site
548473000854	Q-loop/lid; other site
548473000855	ABC transporter signature motif; other site
548473000856	Walker B; other site
548473000857	D-loop; other site
548473000858	H-loop/switch region; other site
548473000859	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
548473000860	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
548473000861	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473000862	ATP binding site [chemical binding]; other site
548473000863	putative Mg++ binding site [ion binding]; other site
548473000864	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
548473000865	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
548473000866	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
548473000867	putative active site [active]
548473000868	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
548473000869	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548473000870	active site turn [active]
548473000871	phosphorylation site [posttranslational modification]
548473000872	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548473000873	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
548473000874	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
548473000875	putative active site [active]
548473000876	Uncharacterized conserved protein [Function unknown]; Region: COG3589
548473000877	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
548473000878	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
548473000879	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548473000880	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548473000881	active site turn [active]
548473000882	phosphorylation site [posttranslational modification]
548473000883	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
548473000884	HPr interaction site; other site
548473000885	glycerol kinase (GK) interaction site [polypeptide binding]; other site
548473000886	active site
548473000887	phosphorylation site [posttranslational modification]
548473000888	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
548473000889	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
548473000890	dimer interface [polypeptide binding]; other site
548473000891	PYR/PP interface [polypeptide binding]; other site
548473000892	TPP binding site [chemical binding]; other site
548473000893	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
548473000894	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
548473000895	TPP-binding site [chemical binding]; other site
548473000896	dimer interface [polypeptide binding]; other site
548473000897	Isochorismatase family; Region: Isochorismatase; pfam00857
548473000898	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
548473000899	catalytic triad [active]
548473000900	conserved cis-peptide bond; other site
548473000901	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
548473000902	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
548473000903	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548473000904	inhibitor-cofactor binding pocket; inhibition site
548473000905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473000906	catalytic residue [active]
548473000907	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
548473000908	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
548473000909	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
548473000910	heterotetramer interface [polypeptide binding]; other site
548473000911	active site pocket [active]
548473000912	cleavage site
548473000913	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
548473000914	nucleotide binding site [chemical binding]; other site
548473000915	N-acetyl-L-glutamate binding site [chemical binding]; other site
548473000916	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
548473000917	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
548473000918	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
548473000919	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
548473000920	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
548473000921	acyl-activating enzyme (AAE) consensus motif; other site
548473000922	AMP binding site [chemical binding]; other site
548473000923	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
548473000924	Condensation domain; Region: Condensation; pfam00668
548473000925	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
548473000926	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
548473000927	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
548473000928	acyl-activating enzyme (AAE) consensus motif; other site
548473000929	AMP binding site [chemical binding]; other site
548473000930	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
548473000931	thioester reductase domain; Region: Thioester-redct; TIGR01746
548473000932	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548473000933	NAD(P) binding site [chemical binding]; other site
548473000934	active site
548473000935	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
548473000936	formate dehydrogenase; Provisional; Region: PRK07574
548473000937	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
548473000938	dimerization interface [polypeptide binding]; other site
548473000939	ligand binding site [chemical binding]; other site
548473000940	NAD binding site [chemical binding]; other site
548473000941	catalytic site [active]
548473000942	Uncharacterized conserved protein [Function unknown]; Region: COG5609
548473000943	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
548473000944	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
548473000945	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
548473000946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
548473000947	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
548473000948	NMT1-like family; Region: NMT1_2; pfam13379
548473000949	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
548473000950	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
548473000951	Walker A/P-loop; other site
548473000952	ATP binding site [chemical binding]; other site
548473000953	Q-loop/lid; other site
548473000954	ABC transporter signature motif; other site
548473000955	Walker B; other site
548473000956	D-loop; other site
548473000957	H-loop/switch region; other site
548473000958	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
548473000959	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
548473000960	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
548473000961	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
548473000962	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
548473000963	NAD(P) binding site [chemical binding]; other site
548473000964	catalytic residues [active]
548473000965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
548473000966	heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313
548473000967	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
548473000968	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
548473000969	active site
548473000970	homodimer interface [polypeptide binding]; other site
548473000971	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
548473000972	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
548473000973	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
548473000974	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
548473000975	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
548473000976	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
548473000977	putative NAD(P) binding site [chemical binding]; other site
548473000978	active site
548473000979	putative substrate binding site [chemical binding]; other site
548473000980	Bacterial sugar transferase; Region: Bac_transf; pfam02397
548473000981	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548473000982	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
548473000983	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
548473000984	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
548473000985	trimer interface [polypeptide binding]; other site
548473000986	active site
548473000987	substrate binding site [chemical binding]; other site
548473000988	CoA binding site [chemical binding]; other site
548473000989	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548473000990	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
548473000991	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
548473000992	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
548473000993	active site
548473000994	homodimer interface [polypeptide binding]; other site
548473000995	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
548473000996	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
548473000997	putative NAD(P) binding site [chemical binding]; other site
548473000998	active site
548473000999	putative substrate binding site [chemical binding]; other site
548473001000	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
548473001001	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
548473001002	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
548473001003	NAD(P) binding site [chemical binding]; other site
548473001004	homodimer interface [polypeptide binding]; other site
548473001005	substrate binding site [chemical binding]; other site
548473001006	active site
548473001007	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
548473001008	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
548473001009	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
548473001010	NAD(P) binding site [chemical binding]; other site
548473001011	homodimer interface [polypeptide binding]; other site
548473001012	substrate binding site [chemical binding]; other site
548473001013	active site
548473001014	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
548473001015	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
548473001016	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
548473001017	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
548473001018	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
548473001019	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
548473001020	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
548473001021	putative catalytic cysteine [active]
548473001022	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
548473001023	putative active site [active]
548473001024	metal binding site [ion binding]; metal-binding site
548473001025	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548473001026	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473001027	non-specific DNA binding site [nucleotide binding]; other site
548473001028	salt bridge; other site
548473001029	sequence-specific DNA binding site [nucleotide binding]; other site
548473001030	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
548473001031	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
548473001032	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
548473001033	active site
548473001034	metal binding site [ion binding]; metal-binding site
548473001035	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
548473001036	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
548473001037	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
548473001038	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
548473001039	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
548473001040	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
548473001041	Walker A/P-loop; other site
548473001042	ATP binding site [chemical binding]; other site
548473001043	Q-loop/lid; other site
548473001044	ABC transporter signature motif; other site
548473001045	Walker B; other site
548473001046	D-loop; other site
548473001047	H-loop/switch region; other site
548473001048	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
548473001049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473001050	dimer interface [polypeptide binding]; other site
548473001051	conserved gate region; other site
548473001052	ABC-ATPase subunit interface; other site
548473001053	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
548473001054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473001055	dimer interface [polypeptide binding]; other site
548473001056	conserved gate region; other site
548473001057	putative PBP binding loops; other site
548473001058	ABC-ATPase subunit interface; other site
548473001059	phosphopentomutase; Provisional; Region: PRK05362
548473001060	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
548473001061	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
548473001062	intersubunit interface [polypeptide binding]; other site
548473001063	active site
548473001064	catalytic residue [active]
548473001065	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473001066	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
548473001067	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
548473001068	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
548473001069	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548473001070	DNA-binding site [nucleotide binding]; DNA binding site
548473001071	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
548473001072	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
548473001073	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
548473001074	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
548473001075	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
548473001076	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
548473001077	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
548473001078	putative ADP-binding pocket [chemical binding]; other site
548473001079	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
548473001080	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
548473001081	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548473001082	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
548473001083	NAD(P) binding site [chemical binding]; other site
548473001084	active site
548473001085	acetoin reductase; Validated; Region: PRK08643
548473001086	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
548473001087	NAD binding site [chemical binding]; other site
548473001088	homotetramer interface [polypeptide binding]; other site
548473001089	homodimer interface [polypeptide binding]; other site
548473001090	active site
548473001091	substrate binding site [chemical binding]; other site
548473001092	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
548473001093	ParB-like nuclease domain; Region: ParBc; pfam02195
548473001094	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
548473001095	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
548473001096	dimer interface [polypeptide binding]; other site
548473001097	active site
548473001098	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548473001099	catalytic residues [active]
548473001100	substrate binding site [chemical binding]; other site
548473001101	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
548473001102	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
548473001103	IucA / IucC family; Region: IucA_IucC; pfam04183
548473001104	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
548473001105	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
548473001106	IucA / IucC family; Region: IucA_IucC; pfam04183
548473001107	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
548473001108	drug efflux system protein MdtG; Provisional; Region: PRK09874
548473001109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473001110	putative substrate translocation pore; other site
548473001111	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
548473001112	IucA / IucC family; Region: IucA_IucC; pfam04183
548473001113	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
548473001114	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
548473001115	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
548473001116	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
548473001117	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
548473001118	dimer interface [polypeptide binding]; other site
548473001119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473001120	catalytic residue [active]
548473001121	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
548473001122	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
548473001123	siderophore binding site; other site
548473001124	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
548473001125	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473001126	ABC-ATPase subunit  interface; other site
548473001127	dimer interface [polypeptide binding]; other site
548473001128	putative PBP binding regions; other site
548473001129	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
548473001130	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473001131	ABC-ATPase subunit  interface; other site
548473001132	dimer interface [polypeptide binding]; other site
548473001133	putative PBP binding regions; other site
548473001134	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
548473001135	Transcriptional regulators [Transcription]; Region: MarR; COG1846
548473001136	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
548473001137	Transcriptional regulators [Transcription]; Region: MarR; COG1846
548473001138	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473001139	B domain; Region: B; pfam02216
548473001140	B domain; Region: B; pfam02216
548473001141	B domain; Region: B; pfam02216
548473001142	B domain; Region: B; pfam02216
548473001143	B domain; Region: B; pfam02216
548473001144	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
548473001145	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
548473001146	L-lactate permease; Region: Lactate_perm; cl00701
548473001147	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
548473001148	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
548473001149	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
548473001150	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
548473001151	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
548473001152	PhoU domain; Region: PhoU; pfam01895
548473001153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473001154	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473001155	putative substrate translocation pore; other site
548473001156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473001157	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
548473001158	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
548473001159	metal binding site [ion binding]; metal-binding site
548473001160	dimer interface [polypeptide binding]; other site
548473001161	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
548473001162	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
548473001163	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
548473001164	Protein of unknown function, DUF576; Region: DUF576; pfam04507
548473001165	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
548473001166	active site
548473001167	catalytic site [active]
548473001168	putative metal binding site [ion binding]; other site
548473001169	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
548473001170	Part of AAA domain; Region: AAA_19; pfam13245
548473001171	AAA domain; Region: AAA_12; pfam13087
548473001172	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
548473001173	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
548473001174	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
548473001175	FMN binding site [chemical binding]; other site
548473001176	active site
548473001177	catalytic residues [active]
548473001178	substrate binding site [chemical binding]; other site
548473001179	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473001180	Coenzyme A binding pocket [chemical binding]; other site
548473001181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548473001182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548473001183	potential frameshift: common BLAST hit: gi|379022384|ref|YP_005299046.1| N-hydroxyarylamine O-acetyltransferase
548473001184	N-acetyltransferase; Region: Acetyltransf_2; cl00949
548473001185	N-acetyltransferase; Region: Acetyltransf_2; cl00949
548473001186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473001187	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473001188	putative substrate translocation pore; other site
548473001189	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
548473001190	active site
548473001191	transposase; Provisional; Region: PRK06526
548473001192	5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736
548473001193	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473001194	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
548473001195	Walker A motif; other site
548473001196	ATP binding site [chemical binding]; other site
548473001197	Walker B motif; other site
548473001198	arginine finger; other site
548473001199	potential frameshift: common BLAST hit: gi|49484823|ref|YP_042047.1| transposase
548473001200	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473001201	Helix-turn-helix domain; Region: HTH_38; pfam13936
548473001202	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473001203	Integrase core domain; Region: rve; pfam00665
548473001204	putative transposase OrfB; Reviewed; Region: PHA02517
548473001205	HTH-like domain; Region: HTH_21; pfam13276
548473001206	Integrase core domain; Region: rve; pfam00665
548473001207	Integrase core domain; Region: rve_3; pfam13683
548473001208	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548473001209	Transposase; Region: HTH_Tnp_1; pfam01527
548473001210	AAA domain; Region: AAA_13; pfam13166
548473001211	Abortive infection C-terminus; Region: Abi_C; pfam14355
548473001212	potential frameshift: common BLAST hit: gi|27466959|ref|NP_763596.1| Abi-alpha protein
548473001213	Divergent AAA domain; Region: AAA_4; pfam04326
548473001214	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
548473001215	Domain of unknown function (DUF927); Region: DUF927; pfam06048
548473001216	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
548473001217	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
548473001218	catalytic residues [active]
548473001219	catalytic nucleophile [active]
548473001220	Recombinase; Region: Recombinase; pfam07508
548473001221	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
548473001222	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
548473001223	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
548473001224	catalytic residues [active]
548473001225	catalytic nucleophile [active]
548473001226	Presynaptic Site I dimer interface [polypeptide binding]; other site
548473001227	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
548473001228	Synaptic Flat tetramer interface [polypeptide binding]; other site
548473001229	Synaptic Site I dimer interface [polypeptide binding]; other site
548473001230	DNA binding site [nucleotide binding]
548473001231	Recombinase; Region: Recombinase; pfam07508
548473001232	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
548473001233	Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262
548473001234	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
548473001235	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
548473001236	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
548473001237	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473001238	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473001239	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
548473001240	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
548473001241	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
548473001242	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
548473001243	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
548473001244	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
548473001245	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
548473001246	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
548473001247	putative active site [active]
548473001248	putative catalytic site [active]
548473001249	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
548473001250	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
548473001251	putative active site [active]
548473001252	catalytic site [active]
548473001253	putative metal binding site [ion binding]; other site
548473001254	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
548473001255	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
548473001256	Integrase core domain; Region: rve; pfam00665
548473001257	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
548473001258	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
548473001259	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
548473001260	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
548473001261	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
548473001262	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
548473001263	putative active site [active]
548473001264	putative metal binding site [ion binding]; other site
548473001265	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
548473001266	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
548473001267	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
548473001268	YycH protein; Region: YycI; cl02015
548473001269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
548473001270	YycH protein; Region: YycH; pfam07435
548473001271	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
548473001272	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
548473001273	dimerization interface [polypeptide binding]; other site
548473001274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
548473001275	putative active site [active]
548473001276	heme pocket [chemical binding]; other site
548473001277	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548473001278	dimer interface [polypeptide binding]; other site
548473001279	phosphorylation site [posttranslational modification]
548473001280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473001281	ATP binding site [chemical binding]; other site
548473001282	Mg2+ binding site [ion binding]; other site
548473001283	G-X-G motif; other site
548473001284	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548473001285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473001286	active site
548473001287	phosphorylation site [posttranslational modification]
548473001288	intermolecular recognition site; other site
548473001289	dimerization interface [polypeptide binding]; other site
548473001290	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548473001291	DNA binding site [nucleotide binding]
548473001292	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
548473001293	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
548473001294	GDP-binding site [chemical binding]; other site
548473001295	ACT binding site; other site
548473001296	IMP binding site; other site
548473001297	replicative DNA helicase; Region: DnaB; TIGR00665
548473001298	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
548473001299	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
548473001300	Walker A motif; other site
548473001301	ATP binding site [chemical binding]; other site
548473001302	Walker B motif; other site
548473001303	DNA binding loops [nucleotide binding]
548473001304	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
548473001305	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
548473001306	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
548473001307	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
548473001308	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
548473001309	DHH family; Region: DHH; pfam01368
548473001310	DHHA1 domain; Region: DHHA1; pfam02272
548473001311	Predicted membrane protein [Function unknown]; Region: COG4241
548473001312	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
548473001313	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
548473001314	Predicted membrane protein [Function unknown]; Region: COG4392
548473001315	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
548473001316	seryl-tRNA synthetase; Provisional; Region: PRK05431
548473001317	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
548473001318	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
548473001319	dimer interface [polypeptide binding]; other site
548473001320	active site
548473001321	motif 1; other site
548473001322	motif 2; other site
548473001323	motif 3; other site
548473001324	T-box leader; HMPREF0772_nc10007
548473001325	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
548473001326	active sites [active]
548473001327	tetramer interface [polypeptide binding]; other site
548473001328	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
548473001329	putative substrate binding site [chemical binding]; other site
548473001330	putative ATP binding site [chemical binding]; other site
548473001331	DNA gyrase subunit A; Validated; Region: PRK05560
548473001332	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
548473001333	CAP-like domain; other site
548473001334	active site
548473001335	primary dimer interface [polypeptide binding]; other site
548473001336	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548473001337	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548473001338	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548473001339	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548473001340	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548473001341	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548473001342	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
548473001343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473001344	Mg2+ binding site [ion binding]; other site
548473001345	G-X-G motif; other site
548473001346	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
548473001347	anchoring element; other site
548473001348	dimer interface [polypeptide binding]; other site
548473001349	ATP binding site [chemical binding]; other site
548473001350	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
548473001351	active site
548473001352	putative metal-binding site [ion binding]; other site
548473001353	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
548473001354	recF protein; Region: recf; TIGR00611
548473001355	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
548473001356	Walker A/P-loop; other site
548473001357	ATP binding site [chemical binding]; other site
548473001358	Q-loop/lid; other site
548473001359	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473001360	ABC transporter signature motif; other site
548473001361	Walker B; other site
548473001362	D-loop; other site
548473001363	H-loop/switch region; other site
548473001364	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
548473001365	DNA polymerase III subunit beta; Validated; Region: PRK05643
548473001366	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
548473001367	putative DNA binding surface [nucleotide binding]; other site
548473001368	dimer interface [polypeptide binding]; other site
548473001369	beta-clamp/clamp loader binding surface; other site
548473001370	beta-clamp/translesion DNA polymerase binding surface; other site
548473001371	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
548473001372	DnaA N-terminal domain; Region: DnaA_N; pfam11638
548473001373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473001374	Walker A motif; other site
548473001375	ATP binding site [chemical binding]; other site
548473001376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
548473001377	Walker B motif; other site
548473001378	arginine finger; other site
548473001379	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
548473001380	DnaA box-binding interface [nucleotide binding]; other site
548473001381	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
548473001382	ribonuclease P; Reviewed; Region: rnpA; PRK00499
548473001383	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
548473001384	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
548473001385	trmE is a tRNA modification GTPase; Region: trmE; cd04164
548473001386	G1 box; other site
548473001387	GTP/Mg2+ binding site [chemical binding]; other site
548473001388	Switch I region; other site
548473001389	G2 box; other site
548473001390	Switch II region; other site
548473001391	G3 box; other site
548473001392	G4 box; other site
548473001393	G5 box; other site
548473001394	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
548473001395	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
548473001396	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
548473001397	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
548473001398	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
548473001399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473001400	S-adenosylmethionine binding site [chemical binding]; other site
548473001401	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
548473001402	ParB-like nuclease domain; Region: ParBc; pfam02195
548473001403	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
548473001404	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
548473001405	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548473001406	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473001407	non-specific DNA binding site [nucleotide binding]; other site
548473001408	salt bridge; other site
548473001409	sequence-specific DNA binding site [nucleotide binding]; other site
548473001410	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
548473001411	DNA-binding site [nucleotide binding]; DNA binding site
548473001412	RNA-binding motif; other site
548473001413	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
548473001414	active site
548473001415	catalytic residues [active]
548473001416	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473001417	Integrase core domain; Region: rve; pfam00665
548473001418	Integrase core domain; Region: rve_3; cl15866
548473001419	FtsX-like permease family; Region: FtsX; pfam02687
548473001420	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548473001421	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548473001422	Walker A/P-loop; other site
548473001423	ATP binding site [chemical binding]; other site
548473001424	Q-loop/lid; other site
548473001425	ABC transporter signature motif; other site
548473001426	Walker B; other site
548473001427	D-loop; other site
548473001428	H-loop/switch region; other site
548473001429	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
548473001430	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
548473001431	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
548473001432	hypothetical protein; Provisional; Region: PRK07758
548473001433	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
548473001434	Predicted permeases [General function prediction only]; Region: RarD; COG2962
548473001435	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
548473001436	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
548473001437	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
548473001438	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
548473001439	transmembrane helices; other site
548473001440	Collagen binding domain; Region: Collagen_bind; pfam05737
548473001441	Cna protein B-type domain; Region: Cna_B; pfam05738
548473001442	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
548473001443	domain interaction interfaces [polypeptide binding]; other site
548473001444	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
548473001445	domain interaction interfaces [polypeptide binding]; other site
548473001446	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
548473001447	domain interaction interfaces [polypeptide binding]; other site
548473001448	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
548473001449	domain interaction interfaces [polypeptide binding]; other site
548473001450	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
548473001451	domain interaction interfaces [polypeptide binding]; other site
548473001452	DinB superfamily; Region: DinB_2; pfam12867
548473001453	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
548473001454	putative substrate binding pocket [chemical binding]; other site
548473001455	AC domain interface; other site
548473001456	catalytic triad [active]
548473001457	AB domain interface; other site
548473001458	interchain disulfide; other site
548473001459	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
548473001460	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
548473001461	active site residue [active]
548473001462	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
548473001463	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
548473001464	Strictosidine synthase; Region: Str_synth; pfam03088
548473001465	Uncharacterized conserved protein [Function unknown]; Region: COG2353
548473001466	Uncharacterized conserved protein [Function unknown]; Region: COG1912
548473001467	hypothetical protein; Provisional; Region: PRK13661
548473001468	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
548473001469	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548473001470	Walker A/P-loop; other site
548473001471	ATP binding site [chemical binding]; other site
548473001472	Q-loop/lid; other site
548473001473	ABC transporter signature motif; other site
548473001474	Walker B; other site
548473001475	D-loop; other site
548473001476	H-loop/switch region; other site
548473001477	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
548473001478	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
548473001479	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548473001480	Walker A/P-loop; other site
548473001481	ATP binding site [chemical binding]; other site
548473001482	Q-loop/lid; other site
548473001483	ABC transporter signature motif; other site
548473001484	Walker B; other site
548473001485	D-loop; other site
548473001486	H-loop/switch region; other site
548473001487	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
548473001488	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
548473001489	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548473001490	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
548473001491	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
548473001492	putative active site [active]
548473001493	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
548473001494	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
548473001495	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
548473001496	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
548473001497	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
548473001498	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
548473001499	NAD binding site [chemical binding]; other site
548473001500	dimerization interface [polypeptide binding]; other site
548473001501	product binding site; other site
548473001502	substrate binding site [chemical binding]; other site
548473001503	zinc binding site [ion binding]; other site
548473001504	catalytic residues [active]
548473001505	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
548473001506	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548473001507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473001508	homodimer interface [polypeptide binding]; other site
548473001509	catalytic residue [active]
548473001510	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
548473001511	putative active site pocket [active]
548473001512	4-fold oligomerization interface [polypeptide binding]; other site
548473001513	metal binding residues [ion binding]; metal-binding site
548473001514	3-fold/trimer interface [polypeptide binding]; other site
548473001515	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
548473001516	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
548473001517	putative active site [active]
548473001518	oxyanion strand; other site
548473001519	catalytic triad [active]
548473001520	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
548473001521	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
548473001522	catalytic residues [active]
548473001523	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
548473001524	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
548473001525	substrate binding site [chemical binding]; other site
548473001526	glutamase interaction surface [polypeptide binding]; other site
548473001527	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
548473001528	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
548473001529	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
548473001530	metal binding site [ion binding]; metal-binding site
548473001531	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
548473001532	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
548473001533	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
548473001534	Acyltransferase family; Region: Acyl_transf_3; pfam01757
548473001535	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
548473001536	intracellular adhesion protein D; Region: PIA_icaD; TIGR03932
548473001537	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
548473001538	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
548473001539	DXD motif; other site
548473001540	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548473001541	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548473001542	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
548473001543	Chain length determinant protein; Region: Wzz; cl15801
548473001544	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
548473001545	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
548473001546	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
548473001547	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
548473001548	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473001549	Coenzyme A binding pocket [chemical binding]; other site
548473001550	methionine sulfoxide reductase A; Provisional; Region: PRK05528
548473001551	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
548473001552	potential frameshift: common BLAST hit: gi|49487435|ref|YP_044656.1| lipoprotein
548473001553	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
548473001554	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
548473001555	legume lectins; Region: lectin_L-type; cd01951
548473001556	homotetramer interaction site [polypeptide binding]; other site
548473001557	carbohydrate binding site [chemical binding]; other site
548473001558	metal binding site [ion binding]; metal-binding site
548473001559	Putative Ig domain; Region: He_PIG; pfam05345
548473001560	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
548473001561	SecY translocase; Region: SecY; pfam00344
548473001562	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
548473001563	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
548473001564	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
548473001565	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
548473001566	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
548473001567	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
548473001568	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
548473001569	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
548473001570	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
548473001571	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
548473001572	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
548473001573	Isochorismatase family; Region: Isochorismatase; pfam00857
548473001574	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
548473001575	catalytic triad [active]
548473001576	conserved cis-peptide bond; other site
548473001577	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
548473001578	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
548473001579	CHAP domain; Region: CHAP; pfam05257
548473001580	Predicted membrane protein [Function unknown]; Region: COG1511
548473001581	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
548473001582	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
548473001583	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
548473001584	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
548473001585	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
548473001586	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
548473001587	active site
548473001588	P-loop; other site
548473001589	phosphorylation site [posttranslational modification]
548473001590	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
548473001591	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548473001592	active site
548473001593	phosphorylation site [posttranslational modification]
548473001594	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
548473001595	HTH domain; Region: HTH_11; pfam08279
548473001596	PRD domain; Region: PRD; pfam00874
548473001597	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
548473001598	active site
548473001599	P-loop; other site
548473001600	phosphorylation site [posttranslational modification]
548473001601	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548473001602	active site
548473001603	phosphorylation site [posttranslational modification]
548473001604	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
548473001605	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
548473001606	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
548473001607	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
548473001608	active site
548473001609	Zn binding site [ion binding]; other site
548473001610	Arginine repressor [Transcription]; Region: ArgR; COG1438
548473001611	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
548473001612	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
548473001613	arginine deiminase; Provisional; Region: PRK01388
548473001614	ornithine carbamoyltransferase; Validated; Region: PRK02102
548473001615	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
548473001616	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
548473001617	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
548473001618	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
548473001619	substrate binding site [chemical binding]; other site
548473001620	nucleotide binding site [chemical binding]; other site
548473001621	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
548473001622	nucleotide binding site [chemical binding]; other site
548473001623	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
548473001624	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
548473001625	ligand binding site [chemical binding]; other site
548473001626	flexible hinge region; other site
548473001627	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
548473001628	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473001629	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
548473001630	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
548473001631	Predicted esterase [General function prediction only]; Region: COG0627
548473001632	S-formylglutathione hydrolase; Region: PLN02442
548473001633	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
548473001634	MarR family; Region: MarR_2; pfam12802
548473001635	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
548473001636	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
548473001637	dimer interface [polypeptide binding]; other site
548473001638	active site
548473001639	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
548473001640	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548473001641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473001642	active site
548473001643	phosphorylation site [posttranslational modification]
548473001644	intermolecular recognition site; other site
548473001645	dimerization interface [polypeptide binding]; other site
548473001646	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548473001647	DNA binding site [nucleotide binding]
548473001648	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
548473001649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473001650	ATP binding site [chemical binding]; other site
548473001651	Mg2+ binding site [ion binding]; other site
548473001652	G-X-G motif; other site
548473001653	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548473001654	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548473001655	Walker A/P-loop; other site
548473001656	ATP binding site [chemical binding]; other site
548473001657	Q-loop/lid; other site
548473001658	ABC transporter signature motif; other site
548473001659	Walker B; other site
548473001660	D-loop; other site
548473001661	H-loop/switch region; other site
548473001662	FtsX-like permease family; Region: FtsX; pfam02687
548473001663	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
548473001664	catalytic residues [active]
548473001665	dimer interface [polypeptide binding]; other site
548473001666	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
548473001667	Flavodoxin; Region: Flavodoxin_1; pfam00258
548473001668	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
548473001669	FAD binding pocket [chemical binding]; other site
548473001670	FAD binding motif [chemical binding]; other site
548473001671	catalytic residues [active]
548473001672	NAD binding pocket [chemical binding]; other site
548473001673	phosphate binding motif [ion binding]; other site
548473001674	beta-alpha-beta structure motif; other site
548473001675	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
548473001676	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
548473001677	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
548473001678	Citrate transporter; Region: CitMHS; pfam03600
548473001679	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
548473001680	Class III ribonucleotide reductase; Region: RNR_III; cd01675
548473001681	effector binding site; other site
548473001682	active site
548473001683	Zn binding site [ion binding]; other site
548473001684	glycine loop; other site
548473001685	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
548473001686	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473001687	FeS/SAM binding site; other site
548473001688	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
548473001689	Predicted transcriptional regulators [Transcription]; Region: COG1510
548473001690	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
548473001691	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
548473001692	tetramerization interface [polypeptide binding]; other site
548473001693	NAD(P) binding site [chemical binding]; other site
548473001694	catalytic residues [active]
548473001695	choline dehydrogenase; Validated; Region: PRK02106
548473001696	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
548473001697	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
548473001698	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
548473001699	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
548473001700	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
548473001701	acyl-activating enzyme (AAE) consensus motif; other site
548473001702	AMP binding site [chemical binding]; other site
548473001703	active site
548473001704	CoA binding site [chemical binding]; other site
548473001705	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
548473001706	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
548473001707	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
548473001708	catalytic residue [active]
548473001709	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
548473001710	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548473001711	inhibitor-cofactor binding pocket; inhibition site
548473001712	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473001713	catalytic residue [active]
548473001714	amino acid transporter; Region: 2A0306; TIGR00909
548473001715	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
548473001716	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
548473001717	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548473001718	NAD binding site [chemical binding]; other site
548473001719	dimer interface [polypeptide binding]; other site
548473001720	substrate binding site [chemical binding]; other site
548473001721	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
548473001722	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
548473001723	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
548473001724	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
548473001725	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
548473001726	oligomerization interface [polypeptide binding]; other site
548473001727	active site
548473001728	metal binding site [ion binding]; metal-binding site
548473001729	pantoate--beta-alanine ligase; Region: panC; TIGR00018
548473001730	Pantoate-beta-alanine ligase; Region: PanC; cd00560
548473001731	active site
548473001732	ATP-binding site [chemical binding]; other site
548473001733	pantoate-binding site; other site
548473001734	HXXH motif; other site
548473001735	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
548473001736	tetramerization interface [polypeptide binding]; other site
548473001737	active site
548473001738	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
548473001739	Predicted acyl esterases [General function prediction only]; Region: COG2936
548473001740	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548473001741	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548473001742	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
548473001743	dimer interface [polypeptide binding]; other site
548473001744	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
548473001745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
548473001746	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
548473001747	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
548473001748	quinone interaction residues [chemical binding]; other site
548473001749	active site
548473001750	catalytic residues [active]
548473001751	FMN binding site [chemical binding]; other site
548473001752	substrate binding site [chemical binding]; other site
548473001753	Phosphotransferase enzyme family; Region: APH; pfam01636
548473001754	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
548473001755	active site
548473001756	ATP binding site [chemical binding]; other site
548473001757	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
548473001758	active site
548473001759	ATP binding site [chemical binding]; other site
548473001760	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
548473001761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
548473001762	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
548473001763	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
548473001764	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
548473001765	Nucleoside recognition; Region: Gate; pfam07670
548473001766	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
548473001767	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
548473001768	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
548473001769	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
548473001770	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
548473001771	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
548473001772	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548473001773	NAD(P) binding site [chemical binding]; other site
548473001774	active site
548473001775	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548473001776	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548473001777	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
548473001778	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
548473001779	NmrA-like family; Region: NmrA; pfam05368
548473001780	NADP binding site [chemical binding]; other site
548473001781	active site
548473001782	regulatory binding site [polypeptide binding]; other site
548473001783	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
548473001784	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
548473001785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
548473001786	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548473001787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548473001788	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
548473001789	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
548473001790	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
548473001791	N-acetyl-D-glucosamine binding site [chemical binding]; other site
548473001792	catalytic residue [active]
548473001793	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
548473001794	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
548473001795	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
548473001796	catalytic triad [active]
548473001797	catalytic triad [active]
548473001798	oxyanion hole [active]
548473001799	Surface antigen [General function prediction only]; Region: COG3942
548473001800	CHAP domain; Region: CHAP; pfam05257
548473001801	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
548473001802	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548473001803	Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237
548473001804	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548473001805	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
548473001806	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
548473001807	active site
548473001808	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
548473001809	active site lid residues [active]
548473001810	substrate binding pocket [chemical binding]; other site
548473001811	catalytic residues [active]
548473001812	substrate-Mg2+ binding site; other site
548473001813	aspartate-rich region 1; other site
548473001814	aspartate-rich region 2; other site
548473001815	phytoene desaturase; Region: crtI_fam; TIGR02734
548473001816	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548473001817	transaminase; Reviewed; Region: PRK08068
548473001818	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548473001819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473001820	homodimer interface [polypeptide binding]; other site
548473001821	catalytic residue [active]
548473001822	D-lactate dehydrogenase; Validated; Region: PRK08605
548473001823	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
548473001824	homodimer interface [polypeptide binding]; other site
548473001825	ligand binding site [chemical binding]; other site
548473001826	NAD binding site [chemical binding]; other site
548473001827	catalytic site [active]
548473001828	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
548473001829	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
548473001830	metal-binding site [ion binding]
548473001831	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
548473001832	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
548473001833	metal-binding site [ion binding]
548473001834	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
548473001835	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
548473001836	metal-binding site [ion binding]
548473001837	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
548473001838	Soluble P-type ATPase [General function prediction only]; Region: COG4087
548473001839	maltose O-acetyltransferase; Provisional; Region: PRK10092
548473001840	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
548473001841	active site
548473001842	substrate binding site [chemical binding]; other site
548473001843	trimer interface [polypeptide binding]; other site
548473001844	CoA binding site [chemical binding]; other site
548473001845	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
548473001846	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
548473001847	Glutamate binding site [chemical binding]; other site
548473001848	homodimer interface [polypeptide binding]; other site
548473001849	NAD binding site [chemical binding]; other site
548473001850	catalytic residues [active]
548473001851	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548473001852	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548473001853	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
548473001854	Protein export membrane protein; Region: SecD_SecF; cl14618
548473001855	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
548473001856	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
548473001857	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
548473001858	G1 box; other site
548473001859	GTP/Mg2+ binding site [chemical binding]; other site
548473001860	Switch I region; other site
548473001861	G2 box; other site
548473001862	G3 box; other site
548473001863	Switch II region; other site
548473001864	G4 box; other site
548473001865	G5 box; other site
548473001866	Nucleoside recognition; Region: Gate; pfam07670
548473001867	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
548473001868	Nucleoside recognition; Region: Gate; pfam07670
548473001869	Virus attachment protein p12 family; Region: P12; pfam12669
548473001870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473001871	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
548473001872	Walker A motif; other site
548473001873	ATP binding site [chemical binding]; other site
548473001874	Walker B motif; other site
548473001875	arginine finger; other site
548473001876	UvrB/uvrC motif; Region: UVR; pfam02151
548473001877	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473001878	Walker A motif; other site
548473001879	ATP binding site [chemical binding]; other site
548473001880	Walker B motif; other site
548473001881	arginine finger; other site
548473001882	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
548473001883	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
548473001884	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
548473001885	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
548473001886	DNA binding site [nucleotide binding]
548473001887	active site
548473001888	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
548473001889	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
548473001890	dimer interface [polypeptide binding]; other site
548473001891	active site
548473001892	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
548473001893	homodimer interface [polypeptide binding]; other site
548473001894	catalytic residues [active]
548473001895	NAD binding site [chemical binding]; other site
548473001896	substrate binding pocket [chemical binding]; other site
548473001897	flexible flap; other site
548473001898	Surface antigen [General function prediction only]; Region: COG3942
548473001899	CHAP domain; Region: CHAP; pfam05257
548473001900	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
548473001901	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548473001902	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548473001903	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
548473001904	putative dimerization interface [polypeptide binding]; other site
548473001905	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
548473001906	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
548473001907	pyruvate oxidase; Provisional; Region: PRK08611
548473001908	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
548473001909	PYR/PP interface [polypeptide binding]; other site
548473001910	tetramer interface [polypeptide binding]; other site
548473001911	dimer interface [polypeptide binding]; other site
548473001912	TPP binding site [chemical binding]; other site
548473001913	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
548473001914	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
548473001915	TPP-binding site [chemical binding]; other site
548473001916	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548473001917	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
548473001918	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548473001919	active site turn [active]
548473001920	phosphorylation site [posttranslational modification]
548473001921	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
548473001922	HPr interaction site; other site
548473001923	glycerol kinase (GK) interaction site [polypeptide binding]; other site
548473001924	active site
548473001925	phosphorylation site [posttranslational modification]
548473001926	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
548473001927	active site
548473001928	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
548473001929	catalytic residues [active]
548473001930	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
548473001931	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
548473001932	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
548473001933	EamA-like transporter family; Region: EamA; pfam00892
548473001934	EamA-like transporter family; Region: EamA; pfam00892
548473001935	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
548473001936	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
548473001937	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
548473001938	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
548473001939	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
548473001940	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
548473001941	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
548473001942	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473001943	Coenzyme A binding pocket [chemical binding]; other site
548473001944	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
548473001945	active site
548473001946	catalytic site [active]
548473001947	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
548473001948	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473001949	active site
548473001950	motif I; other site
548473001951	motif II; other site
548473001952	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473001953	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473001954	D-lactate dehydrogenase; Provisional; Region: PRK12480
548473001955	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
548473001956	homodimer interface [polypeptide binding]; other site
548473001957	ligand binding site [chemical binding]; other site
548473001958	NAD binding site [chemical binding]; other site
548473001959	catalytic site [active]
548473001960	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
548473001961	dimer interface [polypeptide binding]; other site
548473001962	FMN binding site [chemical binding]; other site
548473001963	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
548473001964	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
548473001965	putative metal binding site [ion binding]; other site
548473001966	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
548473001967	Predicted acetyltransferase [General function prediction only]; Region: COG2388
548473001968	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
548473001969	MarR family; Region: MarR; pfam01047
548473001970	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
548473001971	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
548473001972	Zn binding site [ion binding]; other site
548473001973	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
548473001974	Zn binding site [ion binding]; other site
548473001975	Predicted esterase [General function prediction only]; Region: COG0400
548473001976	putative hydrolase; Provisional; Region: PRK11460
548473001977	Uncharacterized membrane protein [Function unknown]; Region: COG3949
548473001978	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
548473001979	potential frameshift: common BLAST hit: gi|379015633|ref|YP_005291869.1| putative membrane spanning protein
548473001980	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
548473001981	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
548473001982	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473001983	Walker A/P-loop; other site
548473001984	ATP binding site [chemical binding]; other site
548473001985	Q-loop/lid; other site
548473001986	ABC transporter signature motif; other site
548473001987	Walker B; other site
548473001988	D-loop; other site
548473001989	H-loop/switch region; other site
548473001990	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
548473001991	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548473001992	DNA-binding site [nucleotide binding]; DNA binding site
548473001993	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548473001994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473001995	homodimer interface [polypeptide binding]; other site
548473001996	catalytic residue [active]
548473001997	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
548473001998	Fatty acid desaturase; Region: FA_desaturase; pfam00487
548473001999	putative di-iron ligands [ion binding]; other site
548473002000	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
548473002001	Lysine efflux permease [General function prediction only]; Region: COG1279
548473002002	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
548473002003	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
548473002004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002005	D-galactonate transporter; Region: 2A0114; TIGR00893
548473002006	putative substrate translocation pore; other site
548473002007	Predicted membrane protein [Function unknown]; Region: COG1289
548473002008	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
548473002009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
548473002010	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
548473002011	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
548473002012	synthetase active site [active]
548473002013	NTP binding site [chemical binding]; other site
548473002014	metal binding site [ion binding]; metal-binding site
548473002015	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
548473002016	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
548473002017	DNA binding residues [nucleotide binding]
548473002018	Transcriptional regulators [Transcription]; Region: GntR; COG1802
548473002019	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548473002020	DNA-binding site [nucleotide binding]; DNA binding site
548473002021	FCD domain; Region: FCD; pfam07729
548473002022	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
548473002023	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
548473002024	N- and C-terminal domain interface [polypeptide binding]; other site
548473002025	active site
548473002026	catalytic site [active]
548473002027	metal binding site [ion binding]; metal-binding site
548473002028	carbohydrate binding site [chemical binding]; other site
548473002029	ATP binding site [chemical binding]; other site
548473002030	GntP family permease; Region: GntP_permease; pfam02447
548473002031	fructuronate transporter; Provisional; Region: PRK10034; cl15264
548473002032	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473002033	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
548473002034	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
548473002035	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473002036	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
548473002037	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
548473002038	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
548473002039	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
548473002040	active site
548473002041	tetramer interface; other site
548473002042	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
548473002043	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
548473002044	active site
548473002045	substrate binding site [chemical binding]; other site
548473002046	metal binding site [ion binding]; metal-binding site
548473002047	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
548473002048	active site
548473002049	8-oxo-dGMP binding site [chemical binding]; other site
548473002050	nudix motif; other site
548473002051	metal binding site [ion binding]; metal-binding site
548473002052	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
548473002053	PLD-like domain; Region: PLDc_2; pfam13091
548473002054	putative homodimer interface [polypeptide binding]; other site
548473002055	putative active site [active]
548473002056	catalytic site [active]
548473002057	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
548473002058	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473002059	ATP binding site [chemical binding]; other site
548473002060	putative Mg++ binding site [ion binding]; other site
548473002061	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548473002062	nucleotide binding region [chemical binding]; other site
548473002063	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
548473002064	ATP-binding site [chemical binding]; other site
548473002065	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
548473002066	Protein of unknown function, DUF576; Region: DUF576; pfam04507
548473002067	Protein of unknown function, DUF576; Region: DUF576; pfam04507
548473002068	Protein of unknown function, DUF576; Region: DUF576; pfam04507
548473002069	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
548473002070	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
548473002071	classical (c) SDRs; Region: SDR_c; cd05233
548473002072	NAD(P) binding site [chemical binding]; other site
548473002073	active site
548473002074	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473002075	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473002076	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473002077	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473002078	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473002079	Uncharacterized conserved protein [Function unknown]; Region: COG2128
548473002080	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
548473002081	AbgT putative transporter family; Region: ABG_transport; cl17431
548473002082	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
548473002083	short chain dehydrogenase; Validated; Region: PRK08589
548473002084	classical (c) SDRs; Region: SDR_c; cd05233
548473002085	NAD(P) binding site [chemical binding]; other site
548473002086	active site
548473002087	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
548473002088	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
548473002089	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
548473002090	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
548473002091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
548473002092	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
548473002093	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
548473002094	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
548473002095	substrate binding site [chemical binding]; other site
548473002096	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
548473002097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473002098	dimer interface [polypeptide binding]; other site
548473002099	conserved gate region; other site
548473002100	putative PBP binding loops; other site
548473002101	ABC-ATPase subunit interface; other site
548473002102	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
548473002103	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
548473002104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473002105	dimer interface [polypeptide binding]; other site
548473002106	conserved gate region; other site
548473002107	putative PBP binding loops; other site
548473002108	ABC-ATPase subunit interface; other site
548473002109	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473002110	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
548473002111	Walker A/P-loop; other site
548473002112	ATP binding site [chemical binding]; other site
548473002113	Q-loop/lid; other site
548473002114	ABC transporter signature motif; other site
548473002115	Walker B; other site
548473002116	D-loop; other site
548473002117	H-loop/switch region; other site
548473002118	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
548473002119	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
548473002120	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473002121	Walker A/P-loop; other site
548473002122	ATP binding site [chemical binding]; other site
548473002123	Q-loop/lid; other site
548473002124	ABC transporter signature motif; other site
548473002125	Walker B; other site
548473002126	D-loop; other site
548473002127	H-loop/switch region; other site
548473002128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002129	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473002130	putative substrate translocation pore; other site
548473002131	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
548473002132	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
548473002133	active site
548473002134	FMN binding site [chemical binding]; other site
548473002135	substrate binding site [chemical binding]; other site
548473002136	3Fe-4S cluster binding site [ion binding]; other site
548473002137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
548473002138	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
548473002139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115
548473002140	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
548473002141	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
548473002142	oligomer interface [polypeptide binding]; other site
548473002143	active site
548473002144	metal binding site [ion binding]; metal-binding site
548473002145	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
548473002146	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548473002147	Walker A/P-loop; other site
548473002148	ATP binding site [chemical binding]; other site
548473002149	Q-loop/lid; other site
548473002150	ABC transporter signature motif; other site
548473002151	Walker B; other site
548473002152	D-loop; other site
548473002153	H-loop/switch region; other site
548473002154	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
548473002155	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
548473002156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002157	putative substrate translocation pore; other site
548473002158	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
548473002159	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
548473002160	substrate binding pocket [chemical binding]; other site
548473002161	catalytic triad [active]
548473002162	amino acid transporter; Region: 2A0306; TIGR00909
548473002163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
548473002164	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
548473002165	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
548473002166	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
548473002167	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
548473002168	Walker A/P-loop; other site
548473002169	ATP binding site [chemical binding]; other site
548473002170	Q-loop/lid; other site
548473002171	ABC transporter signature motif; other site
548473002172	Walker B; other site
548473002173	D-loop; other site
548473002174	H-loop/switch region; other site
548473002175	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
548473002176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473002177	dimer interface [polypeptide binding]; other site
548473002178	conserved gate region; other site
548473002179	putative PBP binding loops; other site
548473002180	ABC-ATPase subunit interface; other site
548473002181	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
548473002182	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
548473002183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473002184	dimer interface [polypeptide binding]; other site
548473002185	conserved gate region; other site
548473002186	ABC-ATPase subunit interface; other site
548473002187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002188	putative substrate translocation pore; other site
548473002189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002190	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
548473002191	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
548473002192	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
548473002193	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
548473002194	extended (e) SDRs; Region: SDR_e; cd08946
548473002195	NAD(P) binding site [chemical binding]; other site
548473002196	active site
548473002197	substrate binding site [chemical binding]; other site
548473002198	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
548473002199	Beta-lactamase; Region: Beta-lactamase; pfam00144
548473002200	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
548473002201	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
548473002202	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
548473002203	Spore germination protein; Region: Spore_permease; cl17796
548473002204	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
548473002205	putative phosphoesterase; Region: acc_ester; TIGR03729
548473002206	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
548473002207	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
548473002208	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
548473002209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002210	putative substrate translocation pore; other site
548473002211	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
548473002212	glycerate kinase; Region: TIGR00045
548473002213	Predicted membrane protein [Function unknown]; Region: COG2246
548473002214	GtrA-like protein; Region: GtrA; pfam04138
548473002215	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548473002216	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548473002217	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473002218	Walker A/P-loop; other site
548473002219	ATP binding site [chemical binding]; other site
548473002220	Q-loop/lid; other site
548473002221	ABC transporter signature motif; other site
548473002222	Walker B; other site
548473002223	D-loop; other site
548473002224	H-loop/switch region; other site
548473002225	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548473002226	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
548473002227	Walker A/P-loop; other site
548473002228	ATP binding site [chemical binding]; other site
548473002229	Q-loop/lid; other site
548473002230	ABC transporter signature motif; other site
548473002231	Walker B; other site
548473002232	D-loop; other site
548473002233	H-loop/switch region; other site
548473002234	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
548473002235	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
548473002236	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548473002237	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
548473002238	inhibitor-cofactor binding pocket; inhibition site
548473002239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473002240	catalytic residue [active]
548473002241	biotin synthase; Validated; Region: PRK06256
548473002242	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473002243	FeS/SAM binding site; other site
548473002244	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
548473002245	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
548473002246	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
548473002247	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548473002248	catalytic residue [active]
548473002249	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
548473002250	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
548473002251	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
548473002252	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
548473002253	B domain; Region: B; pfam02216
548473002254	B domain; Region: B; pfam02216
548473002255	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
548473002256	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
548473002257	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
548473002258	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548473002259	catalytic core [active]
548473002260	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548473002261	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002262	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473002263	putative substrate translocation pore; other site
548473002264	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002265	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
548473002266	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
548473002267	substrate binding pocket [chemical binding]; other site
548473002268	membrane-bound complex binding site; other site
548473002269	hinge residues; other site
548473002270	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
548473002271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473002272	dimer interface [polypeptide binding]; other site
548473002273	conserved gate region; other site
548473002274	putative PBP binding loops; other site
548473002275	ABC-ATPase subunit interface; other site
548473002276	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
548473002277	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
548473002278	Walker A/P-loop; other site
548473002279	ATP binding site [chemical binding]; other site
548473002280	Q-loop/lid; other site
548473002281	ABC transporter signature motif; other site
548473002282	Walker B; other site
548473002283	D-loop; other site
548473002284	H-loop/switch region; other site
548473002285	FemAB family; Region: FemAB; pfam02388
548473002286	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
548473002287	Thioredoxin; Region: Thioredoxin_4; cl17273
548473002288	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
548473002289	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
548473002290	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
548473002291	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548473002292	intersubunit interface [polypeptide binding]; other site
548473002293	YodA lipocalin-like domain; Region: YodA; pfam09223
548473002294	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
548473002295	putative hydrophobic ligand binding site [chemical binding]; other site
548473002296	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
548473002297	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
548473002298	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473002299	Coenzyme A binding pocket [chemical binding]; other site
548473002300	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
548473002301	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
548473002302	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
548473002303	putative active site [active]
548473002304	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
548473002305	active site
548473002306	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
548473002307	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548473002308	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473002309	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
548473002310	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
548473002311	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
548473002312	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
548473002313	[2Fe-2S] cluster binding site [ion binding]; other site
548473002314	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
548473002315	active site
548473002316	SAM binding site [chemical binding]; other site
548473002317	homodimer interface [polypeptide binding]; other site
548473002318	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
548473002319	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
548473002320	[4Fe-4S] binding site [ion binding]; other site
548473002321	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
548473002322	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
548473002323	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
548473002324	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
548473002325	molybdopterin cofactor binding site; other site
548473002326	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
548473002327	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
548473002328	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
548473002329	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
548473002330	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
548473002331	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548473002332	Histidine kinase; Region: HisKA_3; pfam07730
548473002333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473002334	ATP binding site [chemical binding]; other site
548473002335	Mg2+ binding site [ion binding]; other site
548473002336	G-X-G motif; other site
548473002337	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548473002338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473002339	active site
548473002340	phosphorylation site [posttranslational modification]
548473002341	intermolecular recognition site; other site
548473002342	dimerization interface [polypeptide binding]; other site
548473002343	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548473002344	DNA binding residues [nucleotide binding]
548473002345	dimerization interface [polypeptide binding]; other site
548473002346	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
548473002347	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
548473002348	DNA binding residues [nucleotide binding]
548473002349	dimer interface [polypeptide binding]; other site
548473002350	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
548473002351	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
548473002352	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
548473002353	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
548473002354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002355	putative substrate translocation pore; other site
548473002356	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
548473002357	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
548473002358	putative dimer interface [polypeptide binding]; other site
548473002359	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
548473002360	MarR family; Region: MarR_2; pfam12802
548473002361	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
548473002362	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
548473002363	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
548473002364	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
548473002365	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
548473002366	potential frameshift: common BLAST hit: gi|87161309|ref|YP_494961.1| transcription regulatory protein
548473002367	Helix-turn-helix domain; Region: HTH_18; pfam12833
548473002368	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
548473002369	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
548473002370	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
548473002371	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548473002372	active site turn [active]
548473002373	phosphorylation site [posttranslational modification]
548473002374	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548473002375	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
548473002376	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
548473002377	Cl binding site [ion binding]; other site
548473002378	oligomer interface [polypeptide binding]; other site
548473002379	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
548473002380	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
548473002381	Predicted membrane protein [Function unknown]; Region: COG1511
548473002382	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
548473002383	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
548473002384	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
548473002385	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
548473002386	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548473002387	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473002388	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473002389	Coenzyme A binding pocket [chemical binding]; other site
548473002390	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
548473002391	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
548473002392	NAD(P) binding site [chemical binding]; other site
548473002393	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473002394	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
548473002395	Coenzyme A binding pocket [chemical binding]; other site
548473002396	NosL; Region: NosL; cl01769
548473002397	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
548473002398	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
548473002399	L-lactate permease; Region: Lactate_perm; cl00701
548473002400	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
548473002401	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
548473002402	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
548473002403	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
548473002404	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
548473002405	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
548473002406	Walker A/P-loop; other site
548473002407	ATP binding site [chemical binding]; other site
548473002408	Q-loop/lid; other site
548473002409	ABC transporter signature motif; other site
548473002410	Walker B; other site
548473002411	D-loop; other site
548473002412	H-loop/switch region; other site
548473002413	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
548473002414	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
548473002415	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
548473002416	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
548473002417	LytTr DNA-binding domain; Region: LytTR; smart00850
548473002418	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
548473002419	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
548473002420	dimerization interface [polypeptide binding]; other site
548473002421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548473002422	dimer interface [polypeptide binding]; other site
548473002423	phosphorylation site [posttranslational modification]
548473002424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473002425	ATP binding site [chemical binding]; other site
548473002426	Mg2+ binding site [ion binding]; other site
548473002427	G-X-G motif; other site
548473002428	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548473002429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473002430	active site
548473002431	phosphorylation site [posttranslational modification]
548473002432	intermolecular recognition site; other site
548473002433	dimerization interface [polypeptide binding]; other site
548473002434	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548473002435	DNA binding site [nucleotide binding]
548473002436	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
548473002437	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
548473002438	FtsX-like permease family; Region: FtsX; pfam02687
548473002439	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548473002440	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548473002441	Walker A/P-loop; other site
548473002442	ATP binding site [chemical binding]; other site
548473002443	Q-loop/lid; other site
548473002444	ABC transporter signature motif; other site
548473002445	Walker B; other site
548473002446	D-loop; other site
548473002447	H-loop/switch region; other site
548473002448	Uncharacterized conserved protein [Function unknown]; Region: COG1434
548473002449	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
548473002450	putative active site [active]
548473002451	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
548473002452	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548473002453	putative Zn2+ binding site [ion binding]; other site
548473002454	putative DNA binding site [nucleotide binding]; other site
548473002455	Predicted membrane protein [Function unknown]; Region: COG4640
548473002456	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
548473002457	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
548473002458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002459	putative substrate translocation pore; other site
548473002460	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473002461	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
548473002462	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
548473002463	lipoyl-biotinyl attachment site [posttranslational modification]; other site
548473002464	HlyD family secretion protein; Region: HlyD_3; pfam13437
548473002465	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002466	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
548473002467	putative substrate translocation pore; other site
548473002468	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
548473002469	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
548473002470	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
548473002471	active site
548473002472	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
548473002473	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
548473002474	oligomer interface [polypeptide binding]; other site
548473002475	metal binding site [ion binding]; metal-binding site
548473002476	metal binding site [ion binding]; metal-binding site
548473002477	putative Cl binding site [ion binding]; other site
548473002478	aspartate ring; other site
548473002479	basic sphincter; other site
548473002480	hydrophobic gate; other site
548473002481	periplasmic entrance; other site
548473002482	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
548473002483	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
548473002484	homotetramer interface [polypeptide binding]; other site
548473002485	FMN binding site [chemical binding]; other site
548473002486	homodimer contacts [polypeptide binding]; other site
548473002487	putative active site [active]
548473002488	putative substrate binding site [chemical binding]; other site
548473002489	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
548473002490	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
548473002491	active site
548473002492	DNA binding site [nucleotide binding]
548473002493	Predicted membrane protein [Function unknown]; Region: COG3152
548473002494	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
548473002495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473002496	Walker A/P-loop; other site
548473002497	ATP binding site [chemical binding]; other site
548473002498	Q-loop/lid; other site
548473002499	ABC transporter signature motif; other site
548473002500	Walker B; other site
548473002501	D-loop; other site
548473002502	H-loop/switch region; other site
548473002503	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
548473002504	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
548473002505	Uncharacterized conserved protein [Function unknown]; Region: COG1742
548473002506	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
548473002507	active site
548473002508	catalytic residues [active]
548473002509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
548473002510	MOSC domain; Region: MOSC; pfam03473
548473002511	3-alpha domain; Region: 3-alpha; pfam03475
548473002512	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
548473002513	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548473002514	active site
548473002515	dimer interface [polypeptide binding]; other site
548473002516	CAAX protease self-immunity; Region: Abi; pfam02517
548473002517	formimidoylglutamase; Provisional; Region: PRK13775
548473002518	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
548473002519	putative active site [active]
548473002520	putative metal binding site [ion binding]; other site
548473002521	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
548473002522	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
548473002523	active site
548473002524	metal binding site [ion binding]; metal-binding site
548473002525	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548473002526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548473002527	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
548473002528	dimerization interface [polypeptide binding]; other site
548473002529	urocanate hydratase; Provisional; Region: PRK05414
548473002530	imidazolonepropionase; Validated; Region: PRK09356
548473002531	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
548473002532	active site
548473002533	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
548473002534	amidohydrolase; Region: amidohydrolases; TIGR01891
548473002535	metal binding site [ion binding]; metal-binding site
548473002536	dimer interface [polypeptide binding]; other site
548473002537	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548473002538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548473002539	NAD(P) binding site [chemical binding]; other site
548473002540	active site
548473002541	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
548473002542	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
548473002543	putative hydrophobic ligand binding site [chemical binding]; other site
548473002544	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
548473002545	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
548473002546	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
548473002547	putative active site [active]
548473002548	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
548473002549	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548473002550	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548473002551	active site turn [active]
548473002552	phosphorylation site [posttranslational modification]
548473002553	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
548473002554	Sodium Bile acid symporter family; Region: SBF; pfam01758
548473002555	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
548473002556	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473002557	active site
548473002558	motif I; other site
548473002559	motif II; other site
548473002560	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
548473002561	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
548473002562	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
548473002563	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
548473002564	putative active site [active]
548473002565	CAAX protease self-immunity; Region: Abi; pfam02517
548473002566	Predicted transcriptional regulator [Transcription]; Region: COG2378
548473002567	HTH domain; Region: HTH_11; pfam08279
548473002568	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
548473002569	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
548473002570	active site
548473002571	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
548473002572	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
548473002573	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
548473002574	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
548473002575	4Fe-4S binding domain; Region: Fer4; pfam00037
548473002576	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
548473002577	[4Fe-4S] binding site [ion binding]; other site
548473002578	molybdopterin cofactor binding site; other site
548473002579	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
548473002580	molybdopterin cofactor binding site; other site
548473002581	Uncharacterized conserved protein [Function unknown]; Region: COG2427
548473002582	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
548473002583	Lysozyme subfamily 2; Region: LYZ2; smart00047
548473002584	hypothetical protein; Provisional; Region: PRK06753
548473002585	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
548473002586	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
548473002587	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
548473002588	putative ligand binding site [chemical binding]; other site
548473002589	putative NAD binding site [chemical binding]; other site
548473002590	catalytic site [active]
548473002591	Surface antigen [General function prediction only]; Region: COG3942
548473002592	CHAP domain; Region: CHAP; pfam05257
548473002593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
548473002594	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
548473002595	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
548473002596	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
548473002597	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
548473002598	Surface antigen [General function prediction only]; Region: COG3942
548473002599	CHAP domain; Region: CHAP; pfam05257
548473002600	Helix-turn-helix domain; Region: HTH_18; pfam12833
548473002601	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
548473002602	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
548473002603	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
548473002604	Transcriptional regulators [Transcription]; Region: MarR; COG1846
548473002605	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
548473002606	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
548473002607	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
548473002608	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
548473002609	UreF; Region: UreF; pfam01730
548473002610	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
548473002611	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
548473002612	dimer interface [polypeptide binding]; other site
548473002613	catalytic residues [active]
548473002614	urease subunit alpha; Reviewed; Region: ureC; PRK13207
548473002615	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
548473002616	subunit interactions [polypeptide binding]; other site
548473002617	active site
548473002618	flap region; other site
548473002619	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
548473002620	gamma-beta subunit interface [polypeptide binding]; other site
548473002621	alpha-beta subunit interface [polypeptide binding]; other site
548473002622	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
548473002623	alpha-gamma subunit interface [polypeptide binding]; other site
548473002624	beta-gamma subunit interface [polypeptide binding]; other site
548473002625	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
548473002626	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
548473002627	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
548473002628	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
548473002629	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548473002630	intersubunit interface [polypeptide binding]; other site
548473002631	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
548473002632	active site
548473002633	dimerization interface [polypeptide binding]; other site
548473002634	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
548473002635	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473002636	Coenzyme A binding pocket [chemical binding]; other site
548473002637	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
548473002638	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
548473002639	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
548473002640	substrate binding pocket [chemical binding]; other site
548473002641	membrane-bound complex binding site; other site
548473002642	hinge residues; other site
548473002643	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
548473002644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473002645	dimer interface [polypeptide binding]; other site
548473002646	conserved gate region; other site
548473002647	putative PBP binding loops; other site
548473002648	ABC-ATPase subunit interface; other site
548473002649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473002650	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
548473002651	Walker A/P-loop; other site
548473002652	ATP binding site [chemical binding]; other site
548473002653	Q-loop/lid; other site
548473002654	ABC transporter signature motif; other site
548473002655	Walker B; other site
548473002656	D-loop; other site
548473002657	H-loop/switch region; other site
548473002658	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
548473002659	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
548473002660	ATP binding site [chemical binding]; other site
548473002661	substrate interface [chemical binding]; other site
548473002662	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
548473002663	MPT binding site; other site
548473002664	trimer interface [polypeptide binding]; other site
548473002665	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
548473002666	trimer interface [polypeptide binding]; other site
548473002667	dimer interface [polypeptide binding]; other site
548473002668	putative active site [active]
548473002669	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
548473002670	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
548473002671	dimer interface [polypeptide binding]; other site
548473002672	putative functional site; other site
548473002673	putative MPT binding site; other site
548473002674	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
548473002675	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
548473002676	MoaE homodimer interface [polypeptide binding]; other site
548473002677	MoaD interaction [polypeptide binding]; other site
548473002678	active site residues [active]
548473002679	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
548473002680	MoaE interaction surface [polypeptide binding]; other site
548473002681	MoeB interaction surface [polypeptide binding]; other site
548473002682	thiocarboxylated glycine; other site
548473002683	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
548473002684	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
548473002685	GTP binding site; other site
548473002686	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
548473002687	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473002688	FeS/SAM binding site; other site
548473002689	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
548473002690	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
548473002691	Transcriptional regulators [Transcription]; Region: MarR; COG1846
548473002692	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002693	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473002694	putative substrate translocation pore; other site
548473002695	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
548473002696	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
548473002697	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
548473002698	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
548473002699	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
548473002700	Protein export membrane protein; Region: SecD_SecF; cl14618
548473002701	Predicted permeases [General function prediction only]; Region: COG0679
548473002702	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
548473002703	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
548473002704	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473002705	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
548473002706	Coenzyme A binding pocket [chemical binding]; other site
548473002707	DNA topoisomerase III; Provisional; Region: PRK07726
548473002708	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
548473002709	active site
548473002710	putative interdomain interaction site [polypeptide binding]; other site
548473002711	putative metal-binding site [ion binding]; other site
548473002712	putative nucleotide binding site [chemical binding]; other site
548473002713	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
548473002714	domain I; other site
548473002715	DNA binding groove [nucleotide binding]
548473002716	phosphate binding site [ion binding]; other site
548473002717	domain II; other site
548473002718	domain III; other site
548473002719	nucleotide binding site [chemical binding]; other site
548473002720	catalytic site [active]
548473002721	domain IV; other site
548473002722	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
548473002723	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
548473002724	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
548473002725	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
548473002726	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
548473002727	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
548473002728	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
548473002729	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
548473002730	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
548473002731	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
548473002732	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
548473002733	putative translocon binding site; other site
548473002734	protein-rRNA interface [nucleotide binding]; other site
548473002735	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
548473002736	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
548473002737	G-X-X-G motif; other site
548473002738	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
548473002739	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
548473002740	23S rRNA interface [nucleotide binding]; other site
548473002741	5S rRNA interface [nucleotide binding]; other site
548473002742	putative antibiotic binding site [chemical binding]; other site
548473002743	L25 interface [polypeptide binding]; other site
548473002744	L27 interface [polypeptide binding]; other site
548473002745	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
548473002746	23S rRNA interface [nucleotide binding]; other site
548473002747	putative translocon interaction site; other site
548473002748	signal recognition particle (SRP54) interaction site; other site
548473002749	L23 interface [polypeptide binding]; other site
548473002750	trigger factor interaction site; other site
548473002751	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
548473002752	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
548473002753	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
548473002754	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
548473002755	RNA binding site [nucleotide binding]; other site
548473002756	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
548473002757	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
548473002758	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
548473002759	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
548473002760	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
548473002761	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
548473002762	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
548473002763	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
548473002764	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
548473002765	5S rRNA interface [nucleotide binding]; other site
548473002766	L27 interface [polypeptide binding]; other site
548473002767	23S rRNA interface [nucleotide binding]; other site
548473002768	L5 interface [polypeptide binding]; other site
548473002769	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
548473002770	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
548473002771	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
548473002772	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
548473002773	23S rRNA binding site [nucleotide binding]; other site
548473002774	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
548473002775	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
548473002776	SecY translocase; Region: SecY; pfam00344
548473002777	adenylate kinase; Reviewed; Region: adk; PRK00279
548473002778	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
548473002779	AMP-binding site [chemical binding]; other site
548473002780	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
548473002781	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
548473002782	rRNA binding site [nucleotide binding]; other site
548473002783	predicted 30S ribosome binding site; other site
548473002784	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
548473002785	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
548473002786	30S ribosomal protein S13; Region: bact_S13; TIGR03631
548473002787	30S ribosomal protein S11; Validated; Region: PRK05309
548473002788	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
548473002789	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
548473002790	alphaNTD homodimer interface [polypeptide binding]; other site
548473002791	alphaNTD - beta interaction site [polypeptide binding]; other site
548473002792	alphaNTD - beta' interaction site [polypeptide binding]; other site
548473002793	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
548473002794	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
548473002795	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
548473002796	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548473002797	Walker A/P-loop; other site
548473002798	ATP binding site [chemical binding]; other site
548473002799	Q-loop/lid; other site
548473002800	ABC transporter signature motif; other site
548473002801	Walker B; other site
548473002802	D-loop; other site
548473002803	H-loop/switch region; other site
548473002804	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
548473002805	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548473002806	Walker A/P-loop; other site
548473002807	ATP binding site [chemical binding]; other site
548473002808	Q-loop/lid; other site
548473002809	ABC transporter signature motif; other site
548473002810	Walker B; other site
548473002811	D-loop; other site
548473002812	H-loop/switch region; other site
548473002813	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
548473002814	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
548473002815	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
548473002816	dimerization interface 3.5A [polypeptide binding]; other site
548473002817	active site
548473002818	Ribosomal protein L13 leader; HMPREF0772_nc10009
548473002819	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
548473002820	23S rRNA interface [nucleotide binding]; other site
548473002821	L3 interface [polypeptide binding]; other site
548473002822	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
548473002823	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
548473002824	Divergent AAA domain; Region: AAA_4; pfam04326
548473002825	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
548473002826	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548473002827	putative DNA binding site [nucleotide binding]; other site
548473002828	putative Zn2+ binding site [ion binding]; other site
548473002829	Transcriptional regulator; Region: Rrf2; cl17282
548473002830	acetolactate synthase; Reviewed; Region: PRK08617
548473002831	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
548473002832	PYR/PP interface [polypeptide binding]; other site
548473002833	dimer interface [polypeptide binding]; other site
548473002834	TPP binding site [chemical binding]; other site
548473002835	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
548473002836	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
548473002837	TPP-binding site [chemical binding]; other site
548473002838	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
548473002839	MAP domain; Region: MAP; pfam03642
548473002840	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
548473002841	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
548473002842	active site
548473002843	motif I; other site
548473002844	motif II; other site
548473002845	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
548473002846	Peptidase family M23; Region: Peptidase_M23; pfam01551
548473002847	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
548473002848	substrate binding site [chemical binding]; other site
548473002849	catalytic residues [active]
548473002850	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
548473002851	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
548473002852	DNA binding residues [nucleotide binding]
548473002853	putative dimer interface [polypeptide binding]; other site
548473002854	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
548473002855	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
548473002856	active site
548473002857	catalytic tetrad [active]
548473002858	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
548473002859	NAD-dependent deacetylase; Provisional; Region: PRK00481
548473002860	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
548473002861	NAD+ binding site [chemical binding]; other site
548473002862	substrate binding site [chemical binding]; other site
548473002863	putative Zn binding site [ion binding]; other site
548473002864	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
548473002865	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
548473002866	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
548473002867	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
548473002868	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
548473002869	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
548473002870	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
548473002871	putative substrate binding site [chemical binding]; other site
548473002872	putative ATP binding site [chemical binding]; other site
548473002873	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
548473002874	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
548473002875	methionine cluster; other site
548473002876	active site
548473002877	phosphorylation site [posttranslational modification]
548473002878	metal binding site [ion binding]; metal-binding site
548473002879	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
548473002880	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
548473002881	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
548473002882	active site
548473002883	P-loop; other site
548473002884	phosphorylation site [posttranslational modification]
548473002885	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
548473002886	beta-galactosidase; Region: BGL; TIGR03356
548473002887	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
548473002888	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
548473002889	Prostaglandin dehydrogenases; Region: PGDH; cd05288
548473002890	NAD(P) binding site [chemical binding]; other site
548473002891	substrate binding site [chemical binding]; other site
548473002892	dimer interface [polypeptide binding]; other site
548473002893	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
548473002894	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
548473002895	putative NAD(P) binding site [chemical binding]; other site
548473002896	dimer interface [polypeptide binding]; other site
548473002897	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
548473002898	Small integral membrane protein [Function unknown]; Region: COG5547
548473002899	Asp23 family; Region: Asp23; pfam03780
548473002900	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
548473002901	IucA / IucC family; Region: IucA_IucC; pfam04183
548473002902	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
548473002903	H+ Antiporter protein; Region: 2A0121; TIGR00900
548473002904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002905	putative substrate translocation pore; other site
548473002906	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
548473002907	IucA / IucC family; Region: IucA_IucC; pfam04183
548473002908	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
548473002909	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
548473002910	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
548473002911	dimer interface [polypeptide binding]; other site
548473002912	active site
548473002913	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548473002914	substrate binding site [chemical binding]; other site
548473002915	catalytic residue [active]
548473002916	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
548473002917	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
548473002918	siderophore binding site; other site
548473002919	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
548473002920	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473002921	ABC-ATPase subunit  interface; other site
548473002922	dimer interface [polypeptide binding]; other site
548473002923	putative PBP binding regions; other site
548473002924	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
548473002925	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473002926	ABC-ATPase subunit  interface; other site
548473002927	dimer interface [polypeptide binding]; other site
548473002928	putative PBP binding regions; other site
548473002929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
548473002930	Nucleoside recognition; Region: Gate; pfam07670
548473002931	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
548473002932	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
548473002933	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
548473002934	substrate binding site; other site
548473002935	dimerization interface; other site
548473002936	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
548473002937	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
548473002938	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473002939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
548473002941	putative substrate translocation pore; other site
548473002942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473002943	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
548473002944	putative substrate translocation pore; other site
548473002945	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
548473002946	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
548473002947	Walker A motif; other site
548473002948	Arginase family; Region: Arginase; cd09989
548473002949	active site
548473002950	Mn binding site [ion binding]; other site
548473002951	oligomer interface [polypeptide binding]; other site
548473002952	TIGR00159 family protein; Region: TIGR00159
548473002953	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
548473002954	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
548473002955	YbbR-like protein; Region: YbbR; pfam07949
548473002956	YbbR-like protein; Region: YbbR; pfam07949
548473002957	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
548473002958	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
548473002959	active site
548473002960	substrate binding site [chemical binding]; other site
548473002961	metal binding site [ion binding]; metal-binding site
548473002962	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
548473002963	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
548473002964	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473002965	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473002966	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473002967	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473002968	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473002969	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473002970	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
548473002971	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
548473002972	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
548473002973	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548473002974	active site
548473002975	phosphorylation site [posttranslational modification]
548473002976	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
548473002977	HTH domain; Region: HTH_11; pfam08279
548473002978	Mga helix-turn-helix domain; Region: Mga; pfam05043
548473002979	PRD domain; Region: PRD; pfam00874
548473002980	PRD domain; Region: PRD; pfam00874
548473002981	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
548473002982	active site
548473002983	P-loop; other site
548473002984	phosphorylation site [posttranslational modification]
548473002985	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
548473002986	active site
548473002987	phosphorylation site [posttranslational modification]
548473002988	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
548473002989	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
548473002990	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
548473002991	active site
548473002992	P-loop; other site
548473002993	phosphorylation site [posttranslational modification]
548473002994	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
548473002995	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
548473002996	glutaminase active site [active]
548473002997	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
548473002998	dimer interface [polypeptide binding]; other site
548473002999	active site
548473003000	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
548473003001	dimer interface [polypeptide binding]; other site
548473003002	active site
548473003003	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
548473003004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473003005	Walker A/P-loop; other site
548473003006	ATP binding site [chemical binding]; other site
548473003007	Q-loop/lid; other site
548473003008	ABC transporter signature motif; other site
548473003009	Walker B; other site
548473003010	D-loop; other site
548473003011	H-loop/switch region; other site
548473003012	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
548473003013	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473003014	active site
548473003015	motif I; other site
548473003016	motif II; other site
548473003017	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473003018	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
548473003019	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
548473003020	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548473003021	dimerization interface [polypeptide binding]; other site
548473003022	putative DNA binding site [nucleotide binding]; other site
548473003023	putative Zn2+ binding site [ion binding]; other site
548473003024	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
548473003025	NADH(P)-binding; Region: NAD_binding_10; pfam13460
548473003026	NAD(P) binding site [chemical binding]; other site
548473003027	putative active site [active]
548473003028	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
548473003029	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
548473003030	EVE domain; Region: EVE; cl00728
548473003031	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
548473003032	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
548473003033	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
548473003034	dimerization interface [polypeptide binding]; other site
548473003035	DPS ferroxidase diiron center [ion binding]; other site
548473003036	ion pore; other site
548473003037	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
548473003038	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
548473003039	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
548473003040	intersubunit interface [polypeptide binding]; other site
548473003041	active site
548473003042	catalytic residue [active]
548473003043	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
548473003044	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
548473003045	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
548473003046	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
548473003047	Predicted membrane protein [Function unknown]; Region: COG4270
548473003048	S-ribosylhomocysteinase; Provisional; Region: PRK02260
548473003049	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
548473003050	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
548473003051	metal binding site [ion binding]; metal-binding site
548473003052	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
548473003053	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
548473003054	pantothenate kinase; Provisional; Region: PRK13317
548473003055	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
548473003056	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
548473003057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473003058	Coenzyme A binding pocket [chemical binding]; other site
548473003059	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548473003060	Coenzyme A binding pocket [chemical binding]; other site
548473003061	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
548473003062	CTP synthetase; Validated; Region: pyrG; PRK05380
548473003063	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
548473003064	Catalytic site [active]
548473003065	active site
548473003066	UTP binding site [chemical binding]; other site
548473003067	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
548473003068	active site
548473003069	putative oxyanion hole; other site
548473003070	catalytic triad [active]
548473003071	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
548473003072	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
548473003073	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
548473003074	intersubunit interface [polypeptide binding]; other site
548473003075	active site
548473003076	zinc binding site [ion binding]; other site
548473003077	Na+ binding site [ion binding]; other site
548473003078	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
548473003079	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
548473003080	hinge; other site
548473003081	active site
548473003082	Predicted transcriptional regulators [Transcription]; Region: COG1733
548473003083	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
548473003084	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
548473003085	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
548473003086	NAD binding site [chemical binding]; other site
548473003087	catalytic residues [active]
548473003088	transcription termination factor Rho; Provisional; Region: rho; PRK09376
548473003089	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
548473003090	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
548473003091	RNA binding site [nucleotide binding]; other site
548473003092	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
548473003093	multimer interface [polypeptide binding]; other site
548473003094	Walker A motif; other site
548473003095	ATP binding site [chemical binding]; other site
548473003096	Walker B motif; other site
548473003097	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
548473003098	thymidine kinase; Provisional; Region: PRK04296
548473003099	peptide chain release factor 1; Validated; Region: prfA; PRK00591
548473003100	This domain is found in peptide chain release factors; Region: PCRF; smart00937
548473003101	RF-1 domain; Region: RF-1; pfam00472
548473003102	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
548473003103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473003104	S-adenosylmethionine binding site [chemical binding]; other site
548473003105	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
548473003106	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
548473003107	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
548473003108	Low molecular weight phosphatase family; Region: LMWPc; cd00115
548473003109	active site
548473003110	hypothetical protein; Provisional; Region: PRK13690
548473003111	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
548473003112	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
548473003113	dimer interface [polypeptide binding]; other site
548473003114	active site
548473003115	glycine-pyridoxal phosphate binding site [chemical binding]; other site
548473003116	folate binding site [chemical binding]; other site
548473003117	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548473003118	active site
548473003119	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
548473003120	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
548473003121	active site
548473003122	homodimer interface [polypeptide binding]; other site
548473003123	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
548473003124	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
548473003125	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
548473003126	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
548473003127	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
548473003128	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
548473003129	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
548473003130	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
548473003131	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
548473003132	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
548473003133	beta subunit interaction interface [polypeptide binding]; other site
548473003134	Walker A motif; other site
548473003135	ATP binding site [chemical binding]; other site
548473003136	Walker B motif; other site
548473003137	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
548473003138	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
548473003139	core domain interface [polypeptide binding]; other site
548473003140	delta subunit interface [polypeptide binding]; other site
548473003141	epsilon subunit interface [polypeptide binding]; other site
548473003142	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
548473003143	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
548473003144	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
548473003145	alpha subunit interaction interface [polypeptide binding]; other site
548473003146	Walker A motif; other site
548473003147	ATP binding site [chemical binding]; other site
548473003148	Walker B motif; other site
548473003149	inhibitor binding site; inhibition site
548473003150	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
548473003151	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
548473003152	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
548473003153	gamma subunit interface [polypeptide binding]; other site
548473003154	epsilon subunit interface [polypeptide binding]; other site
548473003155	LBP interface [polypeptide binding]; other site
548473003156	Predicted membrane protein [Function unknown]; Region: COG4836
548473003157	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
548473003158	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
548473003159	hinge; other site
548473003160	active site
548473003161	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
548473003162	YwpF-like protein; Region: YwpF; pfam14183
548473003163	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
548473003164	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
548473003165	dimer interface [polypeptide binding]; other site
548473003166	ssDNA binding site [nucleotide binding]; other site
548473003167	tetramer (dimer of dimers) interface [polypeptide binding]; other site
548473003168	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
548473003169	thiaminase II; Region: salvage_TenA; TIGR04306
548473003170	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
548473003171	dimer interface [polypeptide binding]; other site
548473003172	substrate binding site [chemical binding]; other site
548473003173	ATP binding site [chemical binding]; other site
548473003174	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
548473003175	substrate binding site [chemical binding]; other site
548473003176	multimerization interface [polypeptide binding]; other site
548473003177	ATP binding site [chemical binding]; other site
548473003178	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
548473003179	thiamine phosphate binding site [chemical binding]; other site
548473003180	active site
548473003181	pyrophosphate binding site [ion binding]; other site
548473003182	potential frameshift: common BLAST hit: gi|379021766|ref|YP_005298428.1| Inner membrane protein translocase component YidC
548473003183	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
548473003184	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
548473003185	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548473003186	Zn2+ binding site [ion binding]; other site
548473003187	Mg2+ binding site [ion binding]; other site
548473003188	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
548473003189	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
548473003190	putative active site [active]
548473003191	catalytic site [active]
548473003192	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
548473003193	putative active site [active]
548473003194	catalytic site [active]
548473003195	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
548473003196	putative homodimer interface [polypeptide binding]; other site
548473003197	putative homotetramer interface [polypeptide binding]; other site
548473003198	allosteric switch controlling residues; other site
548473003199	putative metal binding site [ion binding]; other site
548473003200	putative homodimer-homodimer interface [polypeptide binding]; other site
548473003201	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
548473003202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473003203	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
548473003204	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
548473003205	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
548473003206	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
548473003207	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
548473003208	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
548473003209	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548473003210	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548473003211	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
548473003212	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
548473003213	ATP binding site [chemical binding]; other site
548473003214	Mg++ binding site [ion binding]; other site
548473003215	motif III; other site
548473003216	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548473003217	nucleotide binding region [chemical binding]; other site
548473003218	ATP-binding site [chemical binding]; other site
548473003219	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548473003220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473003221	active site
548473003222	phosphorylation site [posttranslational modification]
548473003223	intermolecular recognition site; other site
548473003224	dimerization interface [polypeptide binding]; other site
548473003225	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548473003226	DNA binding site [nucleotide binding]
548473003227	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
548473003228	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
548473003229	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
548473003230	Ligand Binding Site [chemical binding]; other site
548473003231	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548473003232	dimer interface [polypeptide binding]; other site
548473003233	phosphorylation site [posttranslational modification]
548473003234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473003235	ATP binding site [chemical binding]; other site
548473003236	Mg2+ binding site [ion binding]; other site
548473003237	G-X-G motif; other site
548473003238	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
548473003239	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
548473003240	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
548473003241	Soluble P-type ATPase [General function prediction only]; Region: COG4087
548473003242	potassium-transporting ATPase subunit C; Provisional; Region: PRK13998
548473003243	Bacterial PH domain; Region: DUF304; cl01348
548473003244	Predicted membrane protein [Function unknown]; Region: COG3428
548473003245	Bacterial PH domain; Region: DUF304; pfam03703
548473003246	Bacterial PH domain; Region: DUF304; pfam03703
548473003247	Uncharacterized conserved protein [Function unknown]; Region: COG3402
548473003248	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
548473003249	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
548473003250	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
548473003251	active site
548473003252	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548473003253	dimer interface [polypeptide binding]; other site
548473003254	substrate binding site [chemical binding]; other site
548473003255	catalytic residues [active]
548473003256	PemK-like protein; Region: PemK; pfam02452
548473003257	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
548473003258	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
548473003259	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
548473003260	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
548473003261	anti sigma factor interaction site; other site
548473003262	regulatory phosphorylation site [posttranslational modification]; other site
548473003263	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
548473003264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473003265	ATP binding site [chemical binding]; other site
548473003266	Mg2+ binding site [ion binding]; other site
548473003267	G-X-G motif; other site
548473003268	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
548473003269	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548473003270	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
548473003271	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548473003272	DNA binding residues [nucleotide binding]
548473003273	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
548473003274	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
548473003275	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
548473003276	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
548473003277	RNA binding site [nucleotide binding]; other site
548473003278	hypothetical protein; Provisional; Region: PRK04351
548473003279	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
548473003280	Transposase; Region: HTH_Tnp_1; cl17663
548473003281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548473003282	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548473003283	Helix-turn-helix domain; Region: HTH_28; pfam13518
548473003284	HTH-like domain; Region: HTH_21; pfam13276
548473003285	Integrase core domain; Region: rve; pfam00665
548473003286	Integrase core domain; Region: rve_3; cl15866
548473003287	threonine dehydratase; Validated; Region: PRK08639
548473003288	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
548473003289	tetramer interface [polypeptide binding]; other site
548473003290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473003291	catalytic residue [active]
548473003292	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
548473003293	putative Ile/Val binding site [chemical binding]; other site
548473003294	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
548473003295	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
548473003296	substrate binding site [chemical binding]; other site
548473003297	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
548473003298	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
548473003299	substrate binding site [chemical binding]; other site
548473003300	ligand binding site [chemical binding]; other site
548473003301	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
548473003302	tartrate dehydrogenase; Region: TTC; TIGR02089
548473003303	2-isopropylmalate synthase; Validated; Region: PRK00915
548473003304	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
548473003305	active site
548473003306	catalytic residues [active]
548473003307	metal binding site [ion binding]; metal-binding site
548473003308	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
548473003309	ketol-acid reductoisomerase; Provisional; Region: PRK05479
548473003310	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
548473003311	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
548473003312	acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562
548473003313	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
548473003314	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
548473003315	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
548473003316	PYR/PP interface [polypeptide binding]; other site
548473003317	dimer interface [polypeptide binding]; other site
548473003318	TPP binding site [chemical binding]; other site
548473003319	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
548473003320	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
548473003321	TPP-binding site [chemical binding]; other site
548473003322	dimer interface [polypeptide binding]; other site
548473003323	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
548473003324	6-phosphogluconate dehydratase; Region: edd; TIGR01196
548473003325	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
548473003326	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
548473003327	Glycoprotease family; Region: Peptidase_M22; pfam00814
548473003328	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
548473003329	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473003330	Coenzyme A binding pocket [chemical binding]; other site
548473003331	UGMP family protein; Validated; Region: PRK09604
548473003332	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
548473003333	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
548473003334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473003335	Walker A/P-loop; other site
548473003336	ATP binding site [chemical binding]; other site
548473003337	Q-loop/lid; other site
548473003338	ABC transporter signature motif; other site
548473003339	Walker B; other site
548473003340	D-loop; other site
548473003341	H-loop/switch region; other site
548473003342	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
548473003343	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548473003344	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548473003345	ABC transporter; Region: ABC_tran_2; pfam12848
548473003346	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548473003347	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
548473003348	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
548473003349	CoA binding domain; Region: CoA_binding; pfam02629
548473003350	Predicted transporter component [General function prediction only]; Region: COG2391
548473003351	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
548473003352	Sulphur transport; Region: Sulf_transp; pfam04143
548473003353	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
548473003354	CPxP  motif; other site
548473003355	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
548473003356	Transcriptional regulators [Transcription]; Region: PurR; COG1609
548473003357	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
548473003358	DNA binding site [nucleotide binding]
548473003359	domain linker motif; other site
548473003360	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
548473003361	dimerization interface [polypeptide binding]; other site
548473003362	ligand binding site [chemical binding]; other site
548473003363	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
548473003364	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
548473003365	substrate binding [chemical binding]; other site
548473003366	active site
548473003367	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
548473003368	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
548473003369	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
548473003370	putative substrate binding site [chemical binding]; other site
548473003371	putative ATP binding site [chemical binding]; other site
548473003372	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
548473003373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473003374	active site
548473003375	phosphorylation site [posttranslational modification]
548473003376	intermolecular recognition site; other site
548473003377	dimerization interface [polypeptide binding]; other site
548473003378	LytTr DNA-binding domain; Region: LytTR; pfam04397
548473003379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473003380	Mg2+ binding site [ion binding]; other site
548473003381	G-X-G motif; other site
548473003382	Staphylococcal AgrD protein; Region: AgrD; smart00794
548473003383	Accessory gene regulator B; Region: AgrB; smart00793
548473003384	Predicted amidohydrolase [General function prediction only]; Region: COG0388
548473003385	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
548473003386	putative active site [active]
548473003387	catalytic triad [active]
548473003388	putative dimer interface [polypeptide binding]; other site
548473003389	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
548473003390	dimer interface [polypeptide binding]; other site
548473003391	FMN binding site [chemical binding]; other site
548473003392	CAAX protease self-immunity; Region: Abi; pfam02517
548473003393	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
548473003394	oligomerisation interface [polypeptide binding]; other site
548473003395	mobile loop; other site
548473003396	roof hairpin; other site
548473003397	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
548473003398	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
548473003399	ring oligomerisation interface [polypeptide binding]; other site
548473003400	ATP/Mg binding site [chemical binding]; other site
548473003401	stacking interactions; other site
548473003402	hinge regions; other site
548473003403	potential frameshift: common BLAST hit: gi|82751605|ref|YP_417346.1| phage-like protein
548473003404	Cation transport protein; Region: TrkH; cl17365
548473003405	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
548473003406	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
548473003407	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
548473003408	metal binding site [ion binding]; metal-binding site
548473003409	dimer interface [polypeptide binding]; other site
548473003410	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
548473003411	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
548473003412	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
548473003413	putative catalytic site [active]
548473003414	phosphate binding site [ion binding]; other site
548473003415	metal binding site A [ion binding]; metal-binding site
548473003416	metal binding site C [ion binding]; metal-binding site
548473003417	metal binding site B [ion binding]; metal-binding site
548473003418	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
548473003419	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
548473003420	Phage-related minor tail protein [Function unknown]; Region: COG5280
548473003421	Phage-related protein [Function unknown]; Region: COG5412
548473003422	Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606
548473003423	Peptidase family M23; Region: Peptidase_M23; pfam01551
548473003424	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
548473003425	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
548473003426	N-acetyl-D-glucosamine binding site [chemical binding]; other site
548473003427	catalytic residue [active]
548473003428	Phage tail protein; Region: Sipho_tail; cl17486
548473003429	Phage tail protein; Region: Sipho_tail; cl17486
548473003430	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
548473003431	TolA protein; Region: tolA_full; TIGR02794
548473003432	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
548473003433	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
548473003434	Small integral membrane protein [Function unknown]; Region: COG5546
548473003435	CHAP domain; Region: CHAP; pfam05257
548473003436	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
548473003437	Bacterial SH3 domain homologues; Region: SH3b; smart00287
548473003438	chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032
548473003439	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
548473003440	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473003441	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473003442	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
548473003443	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473003444	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
548473003445	MAP domain; Region: MAP; pfam03642
548473003446	MAP domain; Region: MAP; pfam03642
548473003447	MAP domain; Region: MAP; pfam03642
548473003448	MAP domain; Region: MAP; pfam03642
548473003449	MAP domain; Region: MAP; pfam03642
548473003450	MAP domain; Region: MAP; pfam03642
548473003451	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
548473003452	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548473003453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473003454	homodimer interface [polypeptide binding]; other site
548473003455	catalytic residue [active]
548473003456	Predicted transcriptional regulators [Transcription]; Region: COG1725
548473003457	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548473003458	DNA-binding site [nucleotide binding]; DNA binding site
548473003459	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
548473003460	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
548473003461	Walker A/P-loop; other site
548473003462	ATP binding site [chemical binding]; other site
548473003463	Q-loop/lid; other site
548473003464	ABC transporter signature motif; other site
548473003465	Walker B; other site
548473003466	D-loop; other site
548473003467	H-loop/switch region; other site
548473003468	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
548473003469	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
548473003470	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
548473003471	Walker A/P-loop; other site
548473003472	ATP binding site [chemical binding]; other site
548473003473	Q-loop/lid; other site
548473003474	ABC transporter signature motif; other site
548473003475	Walker B; other site
548473003476	D-loop; other site
548473003477	H-loop/switch region; other site
548473003478	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
548473003479	Bacterial PH domain; Region: DUF304; cl01348
548473003480	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
548473003481	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
548473003482	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
548473003483	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
548473003484	active site
548473003485	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
548473003486	YolD-like protein; Region: YolD; pfam08863
548473003487	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
548473003488	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
548473003489	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
548473003490	NAD(P) binding site [chemical binding]; other site
548473003491	catalytic residues [active]
548473003492	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
548473003493	DHH family; Region: DHH; pfam01368
548473003494	DHHA2 domain; Region: DHHA2; pfam02833
548473003495	Isochorismatase family; Region: Isochorismatase; pfam00857
548473003496	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
548473003497	catalytic triad [active]
548473003498	conserved cis-peptide bond; other site
548473003499	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
548473003500	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
548473003501	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
548473003502	transmembrane helices; other site
548473003503	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
548473003504	Prephenate dehydratase; Region: PDT; pfam00800
548473003505	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
548473003506	putative L-Phe binding site [chemical binding]; other site
548473003507	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
548473003508	active site
548473003509	dimer interface [polypeptide binding]; other site
548473003510	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
548473003511	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
548473003512	active site
548473003513	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
548473003514	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
548473003515	homodimer interface [polypeptide binding]; other site
548473003516	NAD binding pocket [chemical binding]; other site
548473003517	ATP binding pocket [chemical binding]; other site
548473003518	Mg binding site [ion binding]; other site
548473003519	active-site loop [active]
548473003520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
548473003521	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
548473003522	NETI protein; Region: NETI; pfam14044
548473003523	Staphostatin A; Region: Staphostatin_A; pfam09022
548473003524	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
548473003525	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
548473003526	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
548473003527	tetramer interface [polypeptide binding]; other site
548473003528	active site
548473003529	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
548473003530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
548473003531	PcrB family; Region: PcrB; pfam01884
548473003532	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
548473003533	substrate binding site [chemical binding]; other site
548473003534	putative active site [active]
548473003535	dimer interface [polypeptide binding]; other site
548473003536	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
548473003537	Part of AAA domain; Region: AAA_19; pfam13245
548473003538	Family description; Region: UvrD_C_2; pfam13538
548473003539	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
548473003540	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
548473003541	nucleotide binding pocket [chemical binding]; other site
548473003542	K-X-D-G motif; other site
548473003543	catalytic site [active]
548473003544	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
548473003545	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
548473003546	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
548473003547	Dimer interface [polypeptide binding]; other site
548473003548	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
548473003549	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
548473003550	putative dimer interface [polypeptide binding]; other site
548473003551	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
548473003552	putative dimer interface [polypeptide binding]; other site
548473003553	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
548473003554	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
548473003555	Na binding site [ion binding]; other site
548473003556	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
548473003557	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
548473003558	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
548473003559	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
548473003560	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
548473003561	GatB domain; Region: GatB_Yqey; pfam02637
548473003562	putative lipid kinase; Reviewed; Region: PRK13337
548473003563	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
548473003564	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
548473003565	TRAM domain; Region: TRAM; cl01282
548473003566	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
548473003567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473003568	S-adenosylmethionine binding site [chemical binding]; other site
548473003569	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
548473003570	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
548473003571	active site
548473003572	DNA polymerase IV; Validated; Region: PRK02406
548473003573	DNA binding site [nucleotide binding]
548473003574	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
548473003575	active site
548473003576	catalytic site [active]
548473003577	substrate binding site [chemical binding]; other site
548473003578	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
548473003579	Ferritin-like domain; Region: Ferritin; pfam00210
548473003580	ferroxidase diiron center [ion binding]; other site
548473003581	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
548473003582	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548473003583	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
548473003584	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
548473003585	catalytic triad [active]
548473003586	Predicted membrane protein [Function unknown]; Region: COG4129
548473003587	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
548473003588	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
548473003589	active site
548473003590	Predicted membrane protein [Function unknown]; Region: COG4758
548473003591	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
548473003592	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548473003593	Histidine kinase; Region: HisKA_3; pfam07730
548473003594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473003595	ATP binding site [chemical binding]; other site
548473003596	Mg2+ binding site [ion binding]; other site
548473003597	G-X-G motif; other site
548473003598	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548473003599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473003600	active site
548473003601	phosphorylation site [posttranslational modification]
548473003602	intermolecular recognition site; other site
548473003603	dimerization interface [polypeptide binding]; other site
548473003604	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548473003605	DNA binding residues [nucleotide binding]
548473003606	dimerization interface [polypeptide binding]; other site
548473003607	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
548473003608	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
548473003609	Low molecular weight phosphatase family; Region: LMWPc; cd00115
548473003610	active site
548473003611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840
548473003612	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
548473003613	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
548473003614	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
548473003615	Radical SAM superfamily; Region: Radical_SAM; pfam04055
548473003616	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473003617	FeS/SAM binding site; other site
548473003618	YfkB-like domain; Region: YfkB; pfam08756
548473003619	intracellular protease, PfpI family; Region: PfpI; TIGR01382
548473003620	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
548473003621	proposed catalytic triad [active]
548473003622	conserved cys residue [active]
548473003623	glycosyltransferase; Provisional; Region: PRK13481
548473003624	Transglycosylase; Region: Transgly; pfam00912
548473003625	recombination regulator RecX; Provisional; Region: recX; PRK14135
548473003626	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
548473003627	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
548473003628	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473003629	Walker A/P-loop; other site
548473003630	ATP binding site [chemical binding]; other site
548473003631	Q-loop/lid; other site
548473003632	ABC transporter signature motif; other site
548473003633	Walker B; other site
548473003634	H-loop/switch region; other site
548473003635	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
548473003636	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
548473003637	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
548473003638	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
548473003639	minor groove reading motif; other site
548473003640	helix-hairpin-helix signature motif; other site
548473003641	substrate binding pocket [chemical binding]; other site
548473003642	active site
548473003643	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
548473003644	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
548473003645	DNA binding and oxoG recognition site [nucleotide binding]
548473003646	hypothetical protein; Provisional; Region: PRK13662
548473003647	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548473003648	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548473003649	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
548473003650	Walker A/P-loop; other site
548473003651	ATP binding site [chemical binding]; other site
548473003652	Q-loop/lid; other site
548473003653	ABC transporter signature motif; other site
548473003654	Walker B; other site
548473003655	D-loop; other site
548473003656	H-loop/switch region; other site
548473003657	Predicted membrane protein [Function unknown]; Region: COG4129
548473003658	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
548473003659	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
548473003660	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548473003661	inhibitor-cofactor binding pocket; inhibition site
548473003662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473003663	catalytic residue [active]
548473003664	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
548473003665	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
548473003666	catalytic triad [active]
548473003667	potential frameshift: common BLAST hit: gi|379015065|ref|YP_005291301.1| D-isomer specific 2-hydroxyacid dehydrogenase family protein
548473003668	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
548473003669	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
548473003670	NAD binding site [chemical binding]; other site
548473003671	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
548473003672	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
548473003673	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
548473003674	metal binding site 2 [ion binding]; metal-binding site
548473003675	putative DNA binding helix; other site
548473003676	metal binding site 1 [ion binding]; metal-binding site
548473003677	dimer interface [polypeptide binding]; other site
548473003678	structural Zn2+ binding site [ion binding]; other site
548473003679	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
548473003680	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
548473003681	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
548473003682	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
548473003683	substrate binding pocket [chemical binding]; other site
548473003684	membrane-bound complex binding site; other site
548473003685	hinge residues; other site
548473003686	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
548473003687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473003688	dimer interface [polypeptide binding]; other site
548473003689	conserved gate region; other site
548473003690	putative PBP binding loops; other site
548473003691	ABC-ATPase subunit interface; other site
548473003692	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
548473003693	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
548473003694	Walker A/P-loop; other site
548473003695	ATP binding site [chemical binding]; other site
548473003696	Q-loop/lid; other site
548473003697	ABC transporter signature motif; other site
548473003698	Walker B; other site
548473003699	D-loop; other site
548473003700	H-loop/switch region; other site
548473003701	epoxyqueuosine reductase; Region: TIGR00276
548473003702	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
548473003703	HEAT repeats; Region: HEAT_2; pfam13646
548473003704	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
548473003705	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
548473003706	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
548473003707	active site
548473003708	fumarate hydratase; Reviewed; Region: fumC; PRK00485
548473003709	Class II fumarases; Region: Fumarase_classII; cd01362
548473003710	active site
548473003711	tetramer interface [polypeptide binding]; other site
548473003712	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
548473003713	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
548473003714	active site
548473003715	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
548473003716	GAF domain; Region: GAF_3; pfam13492
548473003717	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548473003718	Histidine kinase; Region: HisKA_3; pfam07730
548473003719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473003720	ATP binding site [chemical binding]; other site
548473003721	Mg2+ binding site [ion binding]; other site
548473003722	G-X-G motif; other site
548473003723	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548473003724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473003725	active site
548473003726	phosphorylation site [posttranslational modification]
548473003727	intermolecular recognition site; other site
548473003728	dimerization interface [polypeptide binding]; other site
548473003729	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548473003730	DNA binding residues [nucleotide binding]
548473003731	dimerization interface [polypeptide binding]; other site
548473003732	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548473003733	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473003734	non-specific DNA binding site [nucleotide binding]; other site
548473003735	salt bridge; other site
548473003736	sequence-specific DNA binding site [nucleotide binding]; other site
548473003737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
548473003738	hypothetical protein; Provisional; Region: PRK13676
548473003739	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
548473003740	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
548473003741	active site
548473003742	metal binding site [ion binding]; metal-binding site
548473003743	DNA binding site [nucleotide binding]
548473003744	Uncharacterized conserved protein [Function unknown]; Region: COG4717
548473003745	P-loop containing region of AAA domain; Region: AAA_29; cl17516
548473003746	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
548473003747	SdpI/YhfL protein family; Region: SdpI; pfam13630
548473003748	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
548473003749	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
548473003750	generic binding surface II; other site
548473003751	generic binding surface I; other site
548473003752	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548473003753	Zn2+ binding site [ion binding]; other site
548473003754	Mg2+ binding site [ion binding]; other site
548473003755	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
548473003756	SurA N-terminal domain; Region: SurA_N_3; cl07813
548473003757	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
548473003758	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
548473003759	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
548473003760	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
548473003761	HIT family signature motif; other site
548473003762	catalytic residue [active]
548473003763	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
548473003764	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
548473003765	Walker A/P-loop; other site
548473003766	ATP binding site [chemical binding]; other site
548473003767	Q-loop/lid; other site
548473003768	ABC transporter signature motif; other site
548473003769	Walker B; other site
548473003770	D-loop; other site
548473003771	H-loop/switch region; other site
548473003772	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
548473003773	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
548473003774	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
548473003775	substrate binding site [chemical binding]; other site
548473003776	active site
548473003777	ferrochelatase; Provisional; Region: PRK12435
548473003778	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
548473003779	C-terminal domain interface [polypeptide binding]; other site
548473003780	active site
548473003781	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
548473003782	active site
548473003783	N-terminal domain interface [polypeptide binding]; other site
548473003784	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
548473003785	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548473003786	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
548473003787	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
548473003788	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
548473003789	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473003790	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
548473003791	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473003792	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
548473003793	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473003794	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
548473003795	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473003796	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
548473003797	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473003798	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
548473003799	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473003800	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
548473003801	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
548473003802	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
548473003803	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
548473003804	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
548473003805	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
548473003806	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
548473003807	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
548473003808	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
548473003809	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
548473003810	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
548473003811	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
548473003812	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
548473003813	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
548473003814	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
548473003815	HsdM N-terminal domain; Region: HsdM_N; pfam12161
548473003816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473003817	S-adenosylmethionine binding site [chemical binding]; other site
548473003818	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
548473003819	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
548473003820	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
548473003821	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
548473003822	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
548473003823	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
548473003824	nucleophilic elbow; other site
548473003825	catalytic triad; other site
548473003826	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473003827	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473003828	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
548473003829	substrate binding site [chemical binding]; other site
548473003830	catalytic residues [active]
548473003831	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473003832	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473003833	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473003834	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
548473003835	Domain of unknown function (DUF955); Region: DUF955; pfam06114
548473003836	FRG domain; Region: FRG; pfam08867
548473003837	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
548473003838	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
548473003839	Excalibur calcium-binding domain; Region: Excalibur; smart00894
548473003840	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
548473003841	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
548473003842	acyl-activating enzyme (AAE) consensus motif; other site
548473003843	putative AMP binding site [chemical binding]; other site
548473003844	putative active site [active]
548473003845	putative CoA binding site [chemical binding]; other site
548473003846	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
548473003847	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
548473003848	metal binding site [ion binding]; metal-binding site
548473003849	substrate binding pocket [chemical binding]; other site
548473003850	Haemolytic domain; Region: Haemolytic; pfam01809
548473003851	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
548473003852	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
548473003853	nudix motif; other site
548473003854	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
548473003855	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
548473003856	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
548473003857	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
548473003858	active site
548473003859	substrate-binding site [chemical binding]; other site
548473003860	metal-binding site [ion binding]
548473003861	ATP binding site [chemical binding]; other site
548473003862	S-adenosylmethionine synthetase; Validated; Region: PRK05250
548473003863	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
548473003864	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
548473003865	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
548473003866	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
548473003867	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
548473003868	active site
548473003869	catalytic tetrad [active]
548473003870	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
548473003871	camphor resistance protein CrcB; Provisional; Region: PRK14201
548473003872	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
548473003873	active site
548473003874	intersubunit interactions; other site
548473003875	catalytic residue [active]
548473003876	CAAX protease self-immunity; Region: Abi; pfam02517
548473003877	CAAX protease self-immunity; Region: Abi; pfam02517
548473003878	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
548473003879	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548473003880	DNA binding residues [nucleotide binding]
548473003881	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
548473003882	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
548473003883	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
548473003884	arsenical pump membrane protein; Provisional; Region: PRK15445
548473003885	transmembrane helices; other site
548473003886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
548473003887	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
548473003888	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
548473003889	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
548473003890	catalytic motif [active]
548473003891	Zn binding site [ion binding]; other site
548473003892	RibD C-terminal domain; Region: RibD_C; cl17279
548473003893	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
548473003894	Lumazine binding domain; Region: Lum_binding; pfam00677
548473003895	Lumazine binding domain; Region: Lum_binding; pfam00677
548473003896	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
548473003897	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
548473003898	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
548473003899	dimerization interface [polypeptide binding]; other site
548473003900	active site
548473003901	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
548473003902	homopentamer interface [polypeptide binding]; other site
548473003903	active site
548473003904	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
548473003905	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
548473003906	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
548473003907	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
548473003908	Methyltransferase domain; Region: Methyltransf_31; pfam13847
548473003909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473003910	S-adenosylmethionine binding site [chemical binding]; other site
548473003911	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
548473003912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473003913	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473003914	putative substrate translocation pore; other site
548473003915	T-box leader; HMPREF0772_nc10018
548473003916	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
548473003917	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
548473003918	HIGH motif; other site
548473003919	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
548473003920	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
548473003921	active site
548473003922	KMSKS motif; other site
548473003923	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
548473003924	tRNA binding surface [nucleotide binding]; other site
548473003925	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
548473003926	active site residue [active]
548473003927	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473003928	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
548473003929	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003930	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003931	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003932	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003933	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003934	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003935	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003936	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003937	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003938	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003939	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003940	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003941	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
548473003942	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
548473003943	HI0933-like protein; Region: HI0933_like; pfam03486
548473003944	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548473003945	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
548473003946	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
548473003947	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
548473003948	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548473003949	RNA binding surface [nucleotide binding]; other site
548473003950	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
548473003951	active site
548473003952	uracil binding [chemical binding]; other site
548473003953	dipeptidase PepV; Reviewed; Region: PRK07318
548473003954	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
548473003955	active site
548473003956	metal binding site [ion binding]; metal-binding site
548473003957	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
548473003958	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
548473003959	homodimer interface [polypeptide binding]; other site
548473003960	substrate-cofactor binding pocket; other site
548473003961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473003962	catalytic residue [active]
548473003963	Phosphotransferase enzyme family; Region: APH; pfam01636
548473003964	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
548473003965	active site
548473003966	substrate binding site [chemical binding]; other site
548473003967	ATP binding site [chemical binding]; other site
548473003968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473003969	S-adenosylmethionine binding site [chemical binding]; other site
548473003970	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
548473003971	Predicted small secreted protein [Function unknown]; Region: COG5584
548473003972	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
548473003973	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
548473003974	oligomer interface [polypeptide binding]; other site
548473003975	active site
548473003976	metal binding site [ion binding]; metal-binding site
548473003977	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
548473003978	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
548473003979	catalytic residues [active]
548473003980	hypothetical protein; Provisional; Region: PRK13668
548473003981	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
548473003982	putative tRNA-binding site [nucleotide binding]; other site
548473003983	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
548473003984	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
548473003985	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
548473003986	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
548473003987	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
548473003988	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548473003989	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548473003990	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
548473003991	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
548473003992	Chorismate mutase type II; Region: CM_2; cl00693
548473003993	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
548473003994	catabolite control protein A; Region: ccpA; TIGR01481
548473003995	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
548473003996	DNA binding site [nucleotide binding]
548473003997	domain linker motif; other site
548473003998	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
548473003999	dimerization interface [polypeptide binding]; other site
548473004000	effector binding site; other site
548473004001	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
548473004002	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
548473004003	active site
548473004004	Zn binding site [ion binding]; other site
548473004005	acetyl-CoA synthetase; Provisional; Region: PRK04319
548473004006	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
548473004007	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
548473004008	active site
548473004009	acyl-activating enzyme (AAE) consensus motif; other site
548473004010	putative CoA binding site [chemical binding]; other site
548473004011	AMP binding site [chemical binding]; other site
548473004012	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
548473004013	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
548473004014	Potassium binding sites [ion binding]; other site
548473004015	Cesium cation binding sites [ion binding]; other site
548473004016	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
548473004017	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
548473004018	NEAr Transporter domain; Region: NEAT; smart00725
548473004019	NEAr Transporter domain; Region: NEAT; smart00725
548473004020	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
548473004021	heme-binding site [chemical binding]; other site
548473004022	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
548473004023	Transglycosylase; Region: Transgly; pfam00912
548473004024	T-box leader; HMPREF0772_nc10019
548473004025	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
548473004026	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
548473004027	active site
548473004028	HIGH motif; other site
548473004029	dimer interface [polypeptide binding]; other site
548473004030	KMSKS motif; other site
548473004031	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548473004032	RNA binding surface [nucleotide binding]; other site
548473004033	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
548473004034	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
548473004035	protein binding site [polypeptide binding]; other site
548473004036	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
548473004037	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
548473004038	putative acyl-acceptor binding pocket; other site
548473004039	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
548473004040	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
548473004041	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
548473004042	active site turn [active]
548473004043	phosphorylation site [posttranslational modification]
548473004044	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
548473004045	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473004046	motif II; other site
548473004047	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
548473004048	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
548473004049	ligand binding site [chemical binding]; other site
548473004050	NAD binding site [chemical binding]; other site
548473004051	dimerization interface [polypeptide binding]; other site
548473004052	catalytic site [active]
548473004053	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
548473004054	putative L-serine binding site [chemical binding]; other site
548473004055	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
548473004056	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548473004057	catalytic residue [active]
548473004058	OsmC-like protein; Region: OsmC; cl00767
548473004059	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
548473004060	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
548473004061	active site
548473004062	catalytic site [active]
548473004063	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
548473004064	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
548473004065	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548473004066	RNA binding surface [nucleotide binding]; other site
548473004067	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
548473004068	GAF domain; Region: GAF_2; pfam13185
548473004069	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
548473004070	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
548473004071	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
548473004072	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548473004073	catalytic residue [active]
548473004074	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
548473004075	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
548473004076	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
548473004077	Ligand Binding Site [chemical binding]; other site
548473004078	hypothetical protein; Provisional; Region: PRK10621
548473004079	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
548473004080	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
548473004081	dimer interface [polypeptide binding]; other site
548473004082	catalytic triad [active]
548473004083	peroxidatic and resolving cysteines [active]
548473004084	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
548473004085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473004086	S-adenosylmethionine binding site [chemical binding]; other site
548473004087	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
548473004088	propionate/acetate kinase; Provisional; Region: PRK12379
548473004089	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
548473004090	Ligand Binding Site [chemical binding]; other site
548473004091	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
548473004092	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
548473004093	hexamer interface [polypeptide binding]; other site
548473004094	ligand binding site [chemical binding]; other site
548473004095	putative active site [active]
548473004096	NAD(P) binding site [chemical binding]; other site
548473004097	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
548473004098	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
548473004099	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
548473004100	active site
548473004101	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
548473004102	metal-dependent hydrolase; Provisional; Region: PRK00685
548473004103	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
548473004104	Ligand Binding Site [chemical binding]; other site
548473004105	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
548473004106	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
548473004107	DNA-binding site [nucleotide binding]; DNA binding site
548473004108	DRTGG domain; Region: DRTGG; pfam07085
548473004109	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
548473004110	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
548473004111	active site 2 [active]
548473004112	active site 1 [active]
548473004113	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
548473004114	DHH family; Region: DHH; pfam01368
548473004115	DHHA1 domain; Region: DHHA1; pfam02272
548473004116	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
548473004117	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
548473004118	active site
548473004119	PHP Thumb interface [polypeptide binding]; other site
548473004120	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
548473004121	generic binding surface I; other site
548473004122	generic binding surface II; other site
548473004123	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
548473004124	Malic enzyme, N-terminal domain; Region: malic; pfam00390
548473004125	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
548473004126	putative NAD(P) binding site [chemical binding]; other site
548473004127	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
548473004128	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
548473004129	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
548473004130	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
548473004131	6-phosphofructokinase; Provisional; Region: PRK03202
548473004132	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
548473004133	active site
548473004134	ADP/pyrophosphate binding site [chemical binding]; other site
548473004135	dimerization interface [polypeptide binding]; other site
548473004136	allosteric effector site; other site
548473004137	fructose-1,6-bisphosphate binding site; other site
548473004138	pyruvate kinase; Provisional; Region: PRK06354
548473004139	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
548473004140	domain interfaces; other site
548473004141	active site
548473004142	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
548473004143	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
548473004144	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
548473004145	dimer interface [polypeptide binding]; other site
548473004146	Citrate synthase; Region: Citrate_synt; pfam00285
548473004147	active site
548473004148	citrylCoA binding site [chemical binding]; other site
548473004149	oxalacetate/citrate binding site [chemical binding]; other site
548473004150	coenzyme A binding site [chemical binding]; other site
548473004151	catalytic triad [active]
548473004152	isocitrate dehydrogenase; Reviewed; Region: PRK07006
548473004153	isocitrate dehydrogenase; Validated; Region: PRK07362
548473004154	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548473004155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473004156	active site
548473004157	phosphorylation site [posttranslational modification]
548473004158	intermolecular recognition site; other site
548473004159	dimerization interface [polypeptide binding]; other site
548473004160	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548473004161	DNA binding site [nucleotide binding]
548473004162	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
548473004163	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548473004164	dimer interface [polypeptide binding]; other site
548473004165	phosphorylation site [posttranslational modification]
548473004166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473004167	ATP binding site [chemical binding]; other site
548473004168	Mg2+ binding site [ion binding]; other site
548473004169	G-X-G motif; other site
548473004170	DNA polymerase I; Provisional; Region: PRK05755
548473004171	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
548473004172	active site
548473004173	metal binding site 1 [ion binding]; metal-binding site
548473004174	putative 5' ssDNA interaction site; other site
548473004175	metal binding site 3; metal-binding site
548473004176	metal binding site 2 [ion binding]; metal-binding site
548473004177	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
548473004178	putative DNA binding site [nucleotide binding]; other site
548473004179	putative metal binding site [ion binding]; other site
548473004180	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
548473004181	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
548473004182	active site
548473004183	DNA binding site [nucleotide binding]
548473004184	catalytic site [active]
548473004185	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
548473004186	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
548473004187	DNA binding site [nucleotide binding]
548473004188	catalytic residue [active]
548473004189	H2TH interface [polypeptide binding]; other site
548473004190	putative catalytic residues [active]
548473004191	turnover-facilitating residue; other site
548473004192	intercalation triad [nucleotide binding]; other site
548473004193	8OG recognition residue [nucleotide binding]; other site
548473004194	putative reading head residues; other site
548473004195	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
548473004196	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
548473004197	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
548473004198	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
548473004199	CoA-binding site [chemical binding]; other site
548473004200	ATP-binding [chemical binding]; other site
548473004201	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
548473004202	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
548473004203	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
548473004204	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
548473004205	ATP cone domain; Region: ATP-cone; pfam03477
548473004206	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
548473004207	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
548473004208	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
548473004209	primosomal protein DnaI; Reviewed; Region: PRK08939
548473004210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473004211	Walker A motif; other site
548473004212	ATP binding site [chemical binding]; other site
548473004213	Walker B motif; other site
548473004214	T-box leader; HMPREF0772_nc10020
548473004215	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
548473004216	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
548473004217	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
548473004218	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
548473004219	active site
548473004220	dimer interface [polypeptide binding]; other site
548473004221	motif 1; other site
548473004222	motif 2; other site
548473004223	motif 3; other site
548473004224	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
548473004225	anticodon binding site; other site
548473004226	lysine transporter; Provisional; Region: PRK10836
548473004227	Ribosomal protein L20 leader; HMPREF0772_nc10022
548473004228	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
548473004229	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
548473004230	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
548473004231	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
548473004232	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
548473004233	23S rRNA binding site [nucleotide binding]; other site
548473004234	L21 binding site [polypeptide binding]; other site
548473004235	L13 binding site [polypeptide binding]; other site
548473004236	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
548473004237	trigger factor; Provisional; Region: tig; PRK01490
548473004238	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
548473004239	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
548473004240	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
548473004241	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
548473004242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473004243	Walker A motif; other site
548473004244	ATP binding site [chemical binding]; other site
548473004245	Walker B motif; other site
548473004246	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
548473004247	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
548473004248	G1 box; other site
548473004249	GTP/Mg2+ binding site [chemical binding]; other site
548473004250	Switch I region; other site
548473004251	G2 box; other site
548473004252	G3 box; other site
548473004253	Switch II region; other site
548473004254	G4 box; other site
548473004255	G5 box; other site
548473004256	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
548473004257	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
548473004258	tRNA; other site
548473004259	putative tRNA binding site [nucleotide binding]; other site
548473004260	putative NADP binding site [chemical binding]; other site
548473004261	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
548473004262	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
548473004263	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
548473004264	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
548473004265	domain interfaces; other site
548473004266	active site
548473004267	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
548473004268	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
548473004269	active site
548473004270	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
548473004271	dimer interface [polypeptide binding]; other site
548473004272	active site
548473004273	Schiff base residues; other site
548473004274	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
548473004275	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548473004276	inhibitor-cofactor binding pocket; inhibition site
548473004277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473004278	catalytic residue [active]
548473004279	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
548473004280	Putative ammonia monooxygenase; Region: AmoA; pfam05145
548473004281	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
548473004282	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
548473004283	T-box leader; HMPREF0772_nc10023
548473004284	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
548473004285	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548473004286	active site
548473004287	HIGH motif; other site
548473004288	nucleotide binding site [chemical binding]; other site
548473004289	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
548473004290	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
548473004291	active site
548473004292	KMSKS motif; other site
548473004293	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
548473004294	tRNA binding surface [nucleotide binding]; other site
548473004295	anticodon binding site; other site
548473004296	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
548473004297	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
548473004298	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548473004299	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548473004300	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
548473004301	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
548473004302	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
548473004303	hypothetical protein; Reviewed; Region: PRK00024
548473004304	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
548473004305	MPN+ (JAMM) motif; other site
548473004306	Zinc-binding site [ion binding]; other site
548473004307	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
548473004308	rod shape-determining protein MreC; Region: MreC; pfam04085
548473004309	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
548473004310	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
548473004311	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
548473004312	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
548473004313	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
548473004314	GTPase CgtA; Reviewed; Region: obgE; PRK12297
548473004315	GTP1/OBG; Region: GTP1_OBG; pfam01018
548473004316	Obg GTPase; Region: Obg; cd01898
548473004317	G1 box; other site
548473004318	GTP/Mg2+ binding site [chemical binding]; other site
548473004319	Switch I region; other site
548473004320	G2 box; other site
548473004321	G3 box; other site
548473004322	Switch II region; other site
548473004323	G4 box; other site
548473004324	G5 box; other site
548473004325	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
548473004326	ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492
548473004327	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
548473004328	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
548473004329	RuvA N terminal domain; Region: RuvA_N; pfam01330
548473004330	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
548473004331	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
548473004332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473004333	Walker A motif; other site
548473004334	ATP binding site [chemical binding]; other site
548473004335	Walker B motif; other site
548473004336	arginine finger; other site
548473004337	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
548473004338	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
548473004339	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
548473004340	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
548473004341	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
548473004342	Preprotein translocase subunit; Region: YajC; pfam02699
548473004343	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
548473004344	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
548473004345	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
548473004346	Protein export membrane protein; Region: SecD_SecF; pfam02355
548473004347	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
548473004348	DHH family; Region: DHH; pfam01368
548473004349	DHHA1 domain; Region: DHHA1; pfam02272
548473004350	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
548473004351	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548473004352	active site
548473004353	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
548473004354	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548473004355	Zn2+ binding site [ion binding]; other site
548473004356	Mg2+ binding site [ion binding]; other site
548473004357	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
548473004358	synthetase active site [active]
548473004359	NTP binding site [chemical binding]; other site
548473004360	metal binding site [ion binding]; metal-binding site
548473004361	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
548473004362	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
548473004363	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
548473004364	putative active site [active]
548473004365	dimerization interface [polypeptide binding]; other site
548473004366	putative tRNAtyr binding site [nucleotide binding]; other site
548473004367	Bacterial SH3 domain homologues; Region: SH3b; smart00287
548473004368	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
548473004369	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
548473004370	active site
548473004371	metal binding site [ion binding]; metal-binding site
548473004372	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
548473004373	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
548473004374	dimer interface [polypeptide binding]; other site
548473004375	motif 1; other site
548473004376	active site
548473004377	motif 2; other site
548473004378	motif 3; other site
548473004379	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
548473004380	anticodon binding site; other site
548473004381	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
548473004382	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
548473004383	dimer interface [polypeptide binding]; other site
548473004384	anticodon binding site; other site
548473004385	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
548473004386	homodimer interface [polypeptide binding]; other site
548473004387	motif 1; other site
548473004388	active site
548473004389	motif 2; other site
548473004390	GAD domain; Region: GAD; pfam02938
548473004391	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
548473004392	motif 3; other site
548473004393	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
548473004394	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
548473004395	putative ATP binding site [chemical binding]; other site
548473004396	putative substrate interface [chemical binding]; other site
548473004397	recombination factor protein RarA; Reviewed; Region: PRK13342
548473004398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473004399	Walker A motif; other site
548473004400	ATP binding site [chemical binding]; other site
548473004401	Walker B motif; other site
548473004402	arginine finger; other site
548473004403	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
548473004404	Predicted transcriptional regulator [Transcription]; Region: COG1959
548473004405	Transcriptional regulator; Region: Rrf2; pfam02082
548473004406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
548473004407	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
548473004408	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
548473004409	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
548473004410	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
548473004411	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548473004412	catalytic residue [active]
548473004413	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
548473004414	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
548473004415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
548473004416	binding surface
548473004417	TPR motif; other site
548473004418	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
548473004419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
548473004420	binding surface
548473004421	TPR motif; other site
548473004422	TPR repeat; Region: TPR_11; pfam13414
548473004423	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
548473004424	AAA domain; Region: AAA_30; pfam13604
548473004425	Family description; Region: UvrD_C_2; pfam13538
548473004426	T-box leader; HMPREF0772_nc10025
548473004427	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
548473004428	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
548473004429	motif 1; other site
548473004430	active site
548473004431	motif 2; other site
548473004432	motif 3; other site
548473004433	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
548473004434	DHHA1 domain; Region: DHHA1; pfam02272
548473004435	hypothetical protein; Provisional; Region: PRK05473
548473004436	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
548473004437	hypothetical protein; Provisional; Region: PRK13678
548473004438	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
548473004439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473004440	S-adenosylmethionine binding site [chemical binding]; other site
548473004441	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
548473004442	Peptidase family U32; Region: Peptidase_U32; pfam01136
548473004443	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
548473004444	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
548473004445	Peptidase family U32; Region: Peptidase_U32; pfam01136
548473004446	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
548473004447	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
548473004448	Sugar specificity; other site
548473004449	Pyrimidine base specificity; other site
548473004450	ATP-binding site [chemical binding]; other site
548473004451	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
548473004452	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
548473004453	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
548473004454	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
548473004455	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
548473004456	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
548473004457	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
548473004458	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
548473004459	carboxyltransferase (CT) interaction site; other site
548473004460	biotinylation site [posttranslational modification]; other site
548473004461	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548473004462	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
548473004463	ATP-grasp domain; Region: ATP-grasp_4; cl17255
548473004464	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
548473004465	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
548473004466	putative active site [active]
548473004467	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
548473004468	Fic family protein [Function unknown]; Region: COG3177
548473004469	Fic/DOC family; Region: Fic; pfam02661
548473004470	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
548473004471	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473004472	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473004473	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
548473004474	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
548473004475	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
548473004476	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473004477	active site
548473004478	motif I; other site
548473004479	motif II; other site
548473004480	GTPase YqeH; Provisional; Region: PRK13796
548473004481	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
548473004482	GTP/Mg2+ binding site [chemical binding]; other site
548473004483	G4 box; other site
548473004484	G5 box; other site
548473004485	G1 box; other site
548473004486	Switch I region; other site
548473004487	G2 box; other site
548473004488	G3 box; other site
548473004489	Switch II region; other site
548473004490	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
548473004491	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
548473004492	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
548473004493	shikimate binding site; other site
548473004494	NAD(P) binding site [chemical binding]; other site
548473004495	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
548473004496	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
548473004497	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
548473004498	active site
548473004499	(T/H)XGH motif; other site
548473004500	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548473004501	Zn2+ binding site [ion binding]; other site
548473004502	Mg2+ binding site [ion binding]; other site
548473004503	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
548473004504	Methyltransferase domain; Region: Methyltransf_23; pfam13489
548473004505	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473004506	S-adenosylmethionine binding site [chemical binding]; other site
548473004507	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
548473004508	Helix-hairpin-helix motif; Region: HHH; pfam00633
548473004509	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
548473004510	catalytic motif [active]
548473004511	Zn binding site [ion binding]; other site
548473004512	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
548473004513	Competence protein; Region: Competence; pfam03772
548473004514	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
548473004515	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
548473004516	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
548473004517	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
548473004518	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
548473004519	GTP-binding protein LepA; Provisional; Region: PRK05433
548473004520	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
548473004521	G1 box; other site
548473004522	putative GEF interaction site [polypeptide binding]; other site
548473004523	GTP/Mg2+ binding site [chemical binding]; other site
548473004524	Switch I region; other site
548473004525	G2 box; other site
548473004526	G3 box; other site
548473004527	Switch II region; other site
548473004528	G4 box; other site
548473004529	G5 box; other site
548473004530	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
548473004531	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
548473004532	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
548473004533	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
548473004534	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473004535	FeS/SAM binding site; other site
548473004536	HemN C-terminal domain; Region: HemN_C; pfam06969
548473004537	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
548473004538	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
548473004539	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
548473004540	heat shock protein GrpE; Provisional; Region: PRK14140
548473004541	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
548473004542	dimer interface [polypeptide binding]; other site
548473004543	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
548473004544	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
548473004545	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
548473004546	nucleotide binding site [chemical binding]; other site
548473004547	NEF interaction site [polypeptide binding]; other site
548473004548	SBD interface [polypeptide binding]; other site
548473004549	chaperone protein DnaJ; Provisional; Region: PRK14280
548473004550	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
548473004551	HSP70 interaction site [polypeptide binding]; other site
548473004552	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
548473004553	substrate binding site [polypeptide binding]; other site
548473004554	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
548473004555	Zn binding sites [ion binding]; other site
548473004556	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
548473004557	dimer interface [polypeptide binding]; other site
548473004558	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
548473004559	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473004560	S-adenosylmethionine binding site [chemical binding]; other site
548473004561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
548473004562	RNA methyltransferase, RsmE family; Region: TIGR00046
548473004563	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
548473004564	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
548473004565	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473004566	FeS/SAM binding site; other site
548473004567	TRAM domain; Region: TRAM; cl01282
548473004568	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
548473004569	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
548473004570	hypothetical protein; Provisional; Region: PRK13665
548473004571	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
548473004572	PhoH-like protein; Region: PhoH; pfam02562
548473004573	metal-binding heat shock protein; Provisional; Region: PRK00016
548473004574	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
548473004575	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
548473004576	active site
548473004577	catalytic motif [active]
548473004578	Zn binding site [ion binding]; other site
548473004579	GTPase Era; Reviewed; Region: era; PRK00089
548473004580	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
548473004581	G1 box; other site
548473004582	GTP/Mg2+ binding site [chemical binding]; other site
548473004583	Switch I region; other site
548473004584	G2 box; other site
548473004585	Switch II region; other site
548473004586	G3 box; other site
548473004587	G4 box; other site
548473004588	G5 box; other site
548473004589	KH domain; Region: KH_2; pfam07650
548473004590	DNA repair protein RecO; Region: reco; TIGR00613
548473004591	Recombination protein O N terminal; Region: RecO_N; pfam11967
548473004592	Recombination protein O C terminal; Region: RecO_C; pfam02565
548473004593	glycyl-tRNA synthetase; Provisional; Region: PRK04173
548473004594	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
548473004595	motif 1; other site
548473004596	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
548473004597	active site
548473004598	motif 2; other site
548473004599	motif 3; other site
548473004600	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
548473004601	anticodon binding site; other site
548473004602	HTH domain; Region: HTH_11; cl17392
548473004603	FOG: CBS domain [General function prediction only]; Region: COG0517
548473004604	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
548473004605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
548473004606	DNA primase, catalytic core; Region: dnaG; TIGR01391
548473004607	CHC2 zinc finger; Region: zf-CHC2; pfam01807
548473004608	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
548473004609	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
548473004610	active site
548473004611	metal binding site [ion binding]; metal-binding site
548473004612	interdomain interaction site; other site
548473004613	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
548473004614	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
548473004615	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
548473004616	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548473004617	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
548473004618	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
548473004619	DNA binding residues [nucleotide binding]
548473004620	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
548473004621	Family of unknown function (DUF633); Region: DUF633; pfam04816
548473004622	Uncharacterized conserved protein [Function unknown]; Region: COG0327
548473004623	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
548473004624	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
548473004625	Uncharacterized conserved protein [Function unknown]; Region: COG0327
548473004626	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
548473004627	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
548473004628	DEAD-like helicases superfamily; Region: DEXDc; smart00487
548473004629	ATP binding site [chemical binding]; other site
548473004630	Mg++ binding site [ion binding]; other site
548473004631	motif III; other site
548473004632	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548473004633	nucleotide binding region [chemical binding]; other site
548473004634	ATP-binding site [chemical binding]; other site
548473004635	endonuclease IV; Provisional; Region: PRK01060
548473004636	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
548473004637	AP (apurinic/apyrimidinic) site pocket; other site
548473004638	DNA interaction; other site
548473004639	Metal-binding active site; metal-binding site
548473004640	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
548473004641	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
548473004642	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
548473004643	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473004644	ABC-ATPase subunit  interface; other site
548473004645	dimer interface [polypeptide binding]; other site
548473004646	putative PBP binding regions; other site
548473004647	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
548473004648	metal binding site 2 [ion binding]; metal-binding site
548473004649	putative DNA binding helix; other site
548473004650	metal binding site 1 [ion binding]; metal-binding site
548473004651	dimer interface [polypeptide binding]; other site
548473004652	structural Zn2+ binding site [ion binding]; other site
548473004653	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
548473004654	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
548473004655	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
548473004656	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
548473004657	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
548473004658	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
548473004659	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
548473004660	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
548473004661	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
548473004662	Rhomboid family; Region: Rhomboid; pfam01694
548473004663	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
548473004664	binding surface
548473004665	TPR motif; other site
548473004666	TPR repeat; Region: TPR_11; pfam13414
548473004667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
548473004668	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
548473004669	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
548473004670	Uncharacterized conserved protein [Function unknown]; Region: COG0011
548473004671	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
548473004672	Type II/IV secretion system protein; Region: T2SE; pfam00437
548473004673	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
548473004674	Walker A motif; other site
548473004675	ATP binding site [chemical binding]; other site
548473004676	Walker B motif; other site
548473004677	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
548473004678	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
548473004679	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
548473004680	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
548473004681	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
548473004682	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
548473004683	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
548473004684	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
548473004685	ADP binding site [chemical binding]; other site
548473004686	magnesium binding site [ion binding]; other site
548473004687	putative shikimate binding site; other site
548473004688	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
548473004689	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
548473004690	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
548473004691	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
548473004692	tetramer interface [polypeptide binding]; other site
548473004693	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473004694	catalytic residue [active]
548473004695	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
548473004696	tetramer interface [polypeptide binding]; other site
548473004697	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473004698	catalytic residue [active]
548473004699	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
548473004700	active site residue [active]
548473004701	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
548473004702	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
548473004703	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
548473004704	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
548473004705	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
548473004706	active site
548473004707	elongation factor P; Validated; Region: PRK00529
548473004708	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
548473004709	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
548473004710	RNA binding site [nucleotide binding]; other site
548473004711	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
548473004712	RNA binding site [nucleotide binding]; other site
548473004713	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
548473004714	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
548473004715	carboxyltransferase (CT) interaction site; other site
548473004716	biotinylation site [posttranslational modification]; other site
548473004717	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
548473004718	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548473004719	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
548473004720	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
548473004721	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
548473004722	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
548473004723	putative RNA binding site [nucleotide binding]; other site
548473004724	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
548473004725	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
548473004726	generic binding surface II; other site
548473004727	generic binding surface I; other site
548473004728	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
548473004729	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
548473004730	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
548473004731	substrate binding pocket [chemical binding]; other site
548473004732	chain length determination region; other site
548473004733	substrate-Mg2+ binding site; other site
548473004734	catalytic residues [active]
548473004735	aspartate-rich region 1; other site
548473004736	active site lid residues [active]
548473004737	aspartate-rich region 2; other site
548473004738	arginine repressor; Provisional; Region: PRK04280
548473004739	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
548473004740	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
548473004741	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
548473004742	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
548473004743	Walker A/P-loop; other site
548473004744	ATP binding site [chemical binding]; other site
548473004745	Q-loop/lid; other site
548473004746	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
548473004747	ABC transporter signature motif; other site
548473004748	Walker B; other site
548473004749	D-loop; other site
548473004750	H-loop/switch region; other site
548473004751	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
548473004752	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
548473004753	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473004754	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
548473004755	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
548473004756	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
548473004757	tetramer interface [polypeptide binding]; other site
548473004758	TPP-binding site [chemical binding]; other site
548473004759	heterodimer interface [polypeptide binding]; other site
548473004760	phosphorylation loop region [posttranslational modification]
548473004761	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
548473004762	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
548473004763	alpha subunit interface [polypeptide binding]; other site
548473004764	TPP binding site [chemical binding]; other site
548473004765	heterodimer interface [polypeptide binding]; other site
548473004766	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
548473004767	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
548473004768	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
548473004769	E3 interaction surface; other site
548473004770	lipoyl attachment site [posttranslational modification]; other site
548473004771	e3 binding domain; Region: E3_binding; pfam02817
548473004772	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
548473004773	Disulphide isomerase; Region: Disulph_isomer; pfam06491
548473004774	Predicted membrane protein [Function unknown]; Region: COG4129
548473004775	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
548473004776	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
548473004777	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
548473004778	peptidase T-like protein; Region: PepT-like; TIGR01883
548473004779	metal binding site [ion binding]; metal-binding site
548473004780	putative dimer interface [polypeptide binding]; other site
548473004781	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
548473004782	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
548473004783	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
548473004784	H+ Antiporter protein; Region: 2A0121; TIGR00900
548473004785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473004786	putative substrate translocation pore; other site
548473004787	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
548473004788	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
548473004789	substrate binding site [chemical binding]; other site
548473004790	ATP binding site [chemical binding]; other site
548473004791	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
548473004792	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
548473004793	Transcriptional regulators [Transcription]; Region: PurR; COG1609
548473004794	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
548473004795	DNA binding site [nucleotide binding]
548473004796	domain linker motif; other site
548473004797	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
548473004798	putative ligand binding site [chemical binding]; other site
548473004799	putative dimerization interface [polypeptide binding]; other site
548473004800	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
548473004801	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
548473004802	Ca binding site [ion binding]; other site
548473004803	active site
548473004804	catalytic site [active]
548473004805	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
548473004806	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
548473004807	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
548473004808	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
548473004809	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
548473004810	ribonuclease Z; Region: RNase_Z; TIGR02651
548473004811	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
548473004812	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
548473004813	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
548473004814	classical (c) SDRs; Region: SDR_c; cd05233
548473004815	NAD(P) binding site [chemical binding]; other site
548473004816	active site
548473004817	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
548473004818	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
548473004819	active site
548473004820	catalytic tetrad [active]
548473004821	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
548473004822	dimer interface [polypeptide binding]; other site
548473004823	ADP-ribose binding site [chemical binding]; other site
548473004824	active site
548473004825	nudix motif; other site
548473004826	metal binding site [ion binding]; metal-binding site
548473004827	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
548473004828	metal binding site 2 [ion binding]; metal-binding site
548473004829	putative DNA binding helix; other site
548473004830	metal binding site 1 [ion binding]; metal-binding site
548473004831	dimer interface [polypeptide binding]; other site
548473004832	structural Zn2+ binding site [ion binding]; other site
548473004833	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
548473004834	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
548473004835	active site
548473004836	Int/Topo IB signature motif; other site
548473004837	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
548473004838	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
548473004839	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
548473004840	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
548473004841	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548473004842	RNA binding surface [nucleotide binding]; other site
548473004843	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
548473004844	active site
548473004845	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548473004846	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473004847	active site
548473004848	phosphorylation site [posttranslational modification]
548473004849	intermolecular recognition site; other site
548473004850	dimerization interface [polypeptide binding]; other site
548473004851	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548473004852	DNA binding site [nucleotide binding]
548473004853	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
548473004854	dimerization interface [polypeptide binding]; other site
548473004855	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
548473004856	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548473004857	dimer interface [polypeptide binding]; other site
548473004858	phosphorylation site [posttranslational modification]
548473004859	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473004860	ATP binding site [chemical binding]; other site
548473004861	Mg2+ binding site [ion binding]; other site
548473004862	G-X-G motif; other site
548473004863	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
548473004864	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
548473004865	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
548473004866	Int/Topo IB signature motif; other site
548473004867	Domain of unknown function (DUF955); Region: DUF955; pfam06114
548473004868	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548473004869	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473004870	non-specific DNA binding site [nucleotide binding]; other site
548473004871	salt bridge; other site
548473004872	sequence-specific DNA binding site [nucleotide binding]; other site
548473004873	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
548473004874	non-specific DNA binding site [nucleotide binding]; other site
548473004875	salt bridge; other site
548473004876	sequence-specific DNA binding site [nucleotide binding]; other site
548473004877	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
548473004878	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
548473004879	Homeodomain-like domain; Region: HTH_23; pfam13384
548473004880	Protein of unknown function (DUF1270); Region: DUF1270; pfam06900
548473004881	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
548473004882	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
548473004883	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
548473004884	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
548473004885	active site
548473004886	DNA binding site [nucleotide binding]
548473004887	catalytic site [active]
548473004888	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
548473004889	Protein of unknown function (DUF3113); Region: DUF3113; pfam11310
548473004890	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
548473004891	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
548473004892	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
548473004893	Protein of unknown function (DUF1024); Region: DUF1024; pfam06260
548473004894	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
548473004895	trimer interface [polypeptide binding]; other site
548473004896	active site
548473004897	Protein of unknown function (DUF1381); Region: DUF1381; pfam07129
548473004898	Transcriptional activator RinB; Region: RinB; pfam06116
548473004899	Protein of unknown function (DUF1514); Region: DUF1514; pfam07438
548473004900	Virulence-associated protein E; Region: VirE; pfam05272
548473004901	VRR-NUC domain; Region: VRR_NUC; pfam08774
548473004902	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
548473004903	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473004904	ATP binding site [chemical binding]; other site
548473004905	putative Mg++ binding site [ion binding]; other site
548473004906	helicase superfamily c-terminal domain; Region: HELICc; smart00490
548473004907	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
548473004908	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
548473004909	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
548473004910	active site
548473004911	Phage terminase, small subunit; Region: Terminase_4; pfam05119
548473004912	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
548473004913	Phage-related protein [Function unknown]; Region: COG4695; cl01923
548473004914	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
548473004915	Clp protease; Region: CLP_protease; pfam00574
548473004916	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
548473004917	oligomer interface [polypeptide binding]; other site
548473004918	active site residues [active]
548473004919	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
548473004920	Phage capsid family; Region: Phage_capsid; pfam05065
548473004921	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
548473004922	oligomerization interface [polypeptide binding]; other site
548473004923	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
548473004924	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
548473004925	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
548473004926	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
548473004927	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
548473004928	linker region; other site
548473004929	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
548473004930	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
548473004931	Peptidase family M23; Region: Peptidase_M23; pfam01551
548473004932	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
548473004933	N-acetyl-D-glucosamine binding site [chemical binding]; other site
548473004934	catalytic residue [active]
548473004935	Phage tail protein; Region: Sipho_tail; pfam05709
548473004936	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
548473004937	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
548473004938	hypothetical protein; Provisional; Region: PRK05926
548473004939	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
548473004940	Protein of unknown function (DUF2977); Region: DUF2977; pfam11192
548473004941	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693
548473004942	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
548473004943	holin, SPP1 family; Region: holin_SPP1; TIGR01592
548473004944	CHAP domain; Region: CHAP; pfam05257
548473004945	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
548473004946	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
548473004947	active site
548473004948	metal binding site [ion binding]; metal-binding site
548473004949	Bacterial SH3 domain; Region: SH3_5; pfam08460
548473004950	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
548473004951	beta-channel forming cytolysin; Region: hlyII; TIGR01002
548473004952	potential frameshift: common BLAST hit: gi|49483673|ref|YP_040897.1| lipoprotein
548473004953	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
548473004954	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
548473004955	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
548473004956	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
548473004957	Predicted membrane protein [Function unknown]; Region: COG3601
548473004958	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
548473004959	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
548473004960	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
548473004961	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
548473004962	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473004963	ATP binding site [chemical binding]; other site
548473004964	putative Mg++ binding site [ion binding]; other site
548473004965	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548473004966	nucleotide binding region [chemical binding]; other site
548473004967	ATP-binding site [chemical binding]; other site
548473004968	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
548473004969	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
548473004970	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
548473004971	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473004972	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
548473004973	active site
548473004974	homotetramer interface [polypeptide binding]; other site
548473004975	homodimer interface [polypeptide binding]; other site
548473004976	cytidylate kinase; Provisional; Region: cmk; PRK00023
548473004977	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
548473004978	CMP-binding site; other site
548473004979	The sites determining sugar specificity; other site
548473004980	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
548473004981	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
548473004982	RNA binding site [nucleotide binding]; other site
548473004983	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
548473004984	RNA binding site [nucleotide binding]; other site
548473004985	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
548473004986	RNA binding site [nucleotide binding]; other site
548473004987	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
548473004988	RNA binding site [nucleotide binding]; other site
548473004989	GTP-binding protein Der; Reviewed; Region: PRK00093
548473004990	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
548473004991	G1 box; other site
548473004992	GTP/Mg2+ binding site [chemical binding]; other site
548473004993	Switch I region; other site
548473004994	G2 box; other site
548473004995	Switch II region; other site
548473004996	G3 box; other site
548473004997	G4 box; other site
548473004998	G5 box; other site
548473004999	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
548473005000	G1 box; other site
548473005001	GTP/Mg2+ binding site [chemical binding]; other site
548473005002	Switch I region; other site
548473005003	G2 box; other site
548473005004	G3 box; other site
548473005005	Switch II region; other site
548473005006	G4 box; other site
548473005007	G5 box; other site
548473005008	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
548473005009	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
548473005010	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
548473005011	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
548473005012	IHF dimer interface [polypeptide binding]; other site
548473005013	IHF - DNA interface [nucleotide binding]; other site
548473005014	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
548473005015	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
548473005016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473005017	S-adenosylmethionine binding site [chemical binding]; other site
548473005018	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
548473005019	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
548473005020	substrate binding pocket [chemical binding]; other site
548473005021	chain length determination region; other site
548473005022	substrate-Mg2+ binding site; other site
548473005023	catalytic residues [active]
548473005024	aspartate-rich region 1; other site
548473005025	active site lid residues [active]
548473005026	aspartate-rich region 2; other site
548473005027	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
548473005028	active site
548473005029	multimer interface [polypeptide binding]; other site
548473005030	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
548473005031	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
548473005032	Tetramer interface [polypeptide binding]; other site
548473005033	active site
548473005034	FMN-binding site [chemical binding]; other site
548473005035	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
548473005036	active site
548473005037	NAD binding site [chemical binding]; other site
548473005038	metal binding site [ion binding]; metal-binding site
548473005039	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
548473005040	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
548473005041	hinge; other site
548473005042	active site
548473005043	TPR repeat; Region: TPR_11; pfam13414
548473005044	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
548473005045	binding surface
548473005046	TPR motif; other site
548473005047	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
548473005048	TPR motif; other site
548473005049	binding surface
548473005050	Uncharacterized conserved protein [Function unknown]; Region: COG5582
548473005051	UPF0302 domain; Region: UPF0302; pfam08864
548473005052	A short protein domain of unknown function; Region: IDEAL; smart00914
548473005053	Predicted membrane protein [Function unknown]; Region: COG4347
548473005054	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
548473005055	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
548473005056	homodimer interface [polypeptide binding]; other site
548473005057	metal binding site [ion binding]; metal-binding site
548473005058	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
548473005059	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
548473005060	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
548473005061	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
548473005062	active site
548473005063	NTP binding site [chemical binding]; other site
548473005064	metal binding triad [ion binding]; metal-binding site
548473005065	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
548473005066	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
548473005067	Biotin operon repressor [Transcription]; Region: BirA; COG1654
548473005068	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
548473005069	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
548473005070	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
548473005071	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
548473005072	active site
548473005073	catalytic site [active]
548473005074	substrate binding site [chemical binding]; other site
548473005075	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
548473005076	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
548473005077	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
548473005078	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
548473005079	putative dimer interface [polypeptide binding]; other site
548473005080	putative anticodon binding site; other site
548473005081	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
548473005082	homodimer interface [polypeptide binding]; other site
548473005083	motif 1; other site
548473005084	motif 2; other site
548473005085	active site
548473005086	motif 3; other site
548473005087	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
548473005088	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
548473005089	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
548473005090	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
548473005091	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
548473005092	minor groove reading motif; other site
548473005093	helix-hairpin-helix signature motif; other site
548473005094	substrate binding pocket [chemical binding]; other site
548473005095	active site
548473005096	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
548473005097	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
548473005098	Transglycosylase; Region: Transgly; pfam00912
548473005099	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
548473005100	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
548473005101	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
548473005102	hypothetical protein; Provisional; Region: PRK13660
548473005103	cell division protein GpsB; Provisional; Region: PRK14127
548473005104	DivIVA domain; Region: DivI1A_domain; TIGR03544
548473005105	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
548473005106	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
548473005107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
548473005108	Cobalt transport protein component CbiN; Region: CbiN; cl00842
548473005109	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
548473005110	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
548473005111	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
548473005112	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
548473005113	Dynamin family; Region: Dynamin_N; pfam00350
548473005114	G1 box; other site
548473005115	GTP/Mg2+ binding site [chemical binding]; other site
548473005116	G2 box; other site
548473005117	Switch I region; other site
548473005118	G3 box; other site
548473005119	Switch II region; other site
548473005120	G4 box; other site
548473005121	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
548473005122	Dynamin family; Region: Dynamin_N; pfam00350
548473005123	G1 box; other site
548473005124	GTP/Mg2+ binding site [chemical binding]; other site
548473005125	G2 box; other site
548473005126	Switch I region; other site
548473005127	G3 box; other site
548473005128	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
548473005129	G3 box; other site
548473005130	Switch II region; other site
548473005131	GTP/Mg2+ binding site [chemical binding]; other site
548473005132	G4 box; other site
548473005133	G5 box; other site
548473005134	5'-3' exonuclease; Region: 53EXOc; smart00475
548473005135	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
548473005136	active site
548473005137	metal binding site 1 [ion binding]; metal-binding site
548473005138	putative 5' ssDNA interaction site; other site
548473005139	metal binding site 3; metal-binding site
548473005140	metal binding site 2 [ion binding]; metal-binding site
548473005141	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
548473005142	putative DNA binding site [nucleotide binding]; other site
548473005143	putative metal binding site [ion binding]; other site
548473005144	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
548473005145	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
548473005146	hexamer interface [polypeptide binding]; other site
548473005147	ligand binding site [chemical binding]; other site
548473005148	putative active site [active]
548473005149	NAD(P) binding site [chemical binding]; other site
548473005150	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
548473005151	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
548473005152	tetramer interface [polypeptide binding]; other site
548473005153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473005154	catalytic residue [active]
548473005155	Amino acid permease; Region: AA_permease_2; pfam13520
548473005156	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
548473005157	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473005158	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
548473005159	GA module; Region: GA; smart00844
548473005160	GA module; Region: GA; smart00844
548473005161	GA module; Region: GA; smart00844
548473005162	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
548473005163	GA module; Region: GA; smart00844
548473005164	GA module; Region: GA; smart00844
548473005165	GA module; Region: GA; smart00844
548473005166	GA module; Region: GA; smart00844
548473005167	GA module; Region: GA; smart00844
548473005168	GA module; Region: GA; smart00844
548473005169	GA module; Region: GA; smart00844
548473005170	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
548473005171	GA module; Region: GA; smart00844
548473005172	GA module; Region: GA; smart00844
548473005173	GA module; Region: GA; smart00844
548473005174	GA module; Region: GA; smart00844
548473005175	GA module; Region: GA; smart00844
548473005176	GA module; Region: GA; smart00844
548473005177	GA module; Region: GA; smart00844
548473005178	GA module; Region: GA; smart00844
548473005179	GA module; Region: GA; smart00844
548473005180	GA module; Region: GA; smart00844
548473005181	GA module; Region: GA; smart00844
548473005182	GA module; Region: GA; smart00844
548473005183	GA module; Region: GA; pfam01468
548473005184	GA module; Region: GA; smart00844
548473005185	GA module; Region: GA; smart00844
548473005186	GA module; Region: GA; smart00844
548473005187	GA module; Region: GA; smart00844
548473005188	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
548473005189	GA module; Region: GA; smart00844
548473005190	GA module; Region: GA; smart00844
548473005191	GA module; Region: GA; smart00844
548473005192	GA module; Region: GA; smart00844
548473005193	GA module; Region: GA; smart00844
548473005194	GA module; Region: GA; smart00844
548473005195	GA module; Region: GA; smart00844
548473005196	GA module; Region: GA; pfam01468
548473005197	GA module; Region: GA; smart00844
548473005198	GA module; Region: GA; smart00844
548473005199	GA module; Region: GA; smart00844
548473005200	GA module; Region: GA; smart00844
548473005201	GA module; Region: GA; smart00844
548473005202	GA module; Region: GA; cl08325
548473005203	chromosome segregation protein; Provisional; Region: PRK02224
548473005204	GA module; Region: GA; smart00844
548473005205	GA module; Region: GA; smart00844
548473005206	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
548473005207	GA module; Region: GA; pfam01468
548473005208	GA module; Region: GA; smart00844
548473005209	GA module; Region: GA; smart00844
548473005210	GA module; Region: GA; smart00844
548473005211	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
548473005212	RNA/DNA hybrid binding site [nucleotide binding]; other site
548473005213	active site
548473005214	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
548473005215	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
548473005216	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
548473005217	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
548473005218	Virulence factor; Region: Virulence_fact; pfam13769
548473005219	HEAT repeats; Region: HEAT_2; pfam13646
548473005220	HEAT repeat; Region: HEAT; pfam02985
548473005221	Disulphide isomerase; Region: Disulph_isomer; cl05813
548473005222	thymidylate synthase; Region: thym_sym; TIGR03284
548473005223	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
548473005224	dimerization interface [polypeptide binding]; other site
548473005225	active site
548473005226	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
548473005227	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
548473005228	folate binding site [chemical binding]; other site
548473005229	NADP+ binding site [chemical binding]; other site
548473005230	EDD domain protein, DegV family; Region: DegV; TIGR00762
548473005231	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
548473005232	methionine sulfoxide reductase A; Provisional; Region: PRK13014
548473005233	methionine sulfoxide reductase B; Provisional; Region: PRK00222
548473005234	SelR domain; Region: SelR; pfam01641
548473005235	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
548473005236	HPr interaction site; other site
548473005237	glycerol kinase (GK) interaction site [polypeptide binding]; other site
548473005238	active site
548473005239	phosphorylation site [posttranslational modification]
548473005240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479
548473005241	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473005242	Helix-turn-helix domain; Region: HTH_38; pfam13936
548473005243	Integrase core domain; Region: rve; pfam00665
548473005244	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
548473005245	C-terminal peptidase (prc); Region: prc; TIGR00225
548473005246	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
548473005247	protein binding site [polypeptide binding]; other site
548473005248	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
548473005249	Catalytic dyad [active]
548473005250	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
548473005251	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473005252	Coenzyme A binding pocket [chemical binding]; other site
548473005253	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
548473005254	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
548473005255	active site
548473005256	homodimer interface [polypeptide binding]; other site
548473005257	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
548473005258	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
548473005259	active site
548473005260	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548473005261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473005262	active site
548473005263	phosphorylation site [posttranslational modification]
548473005264	intermolecular recognition site; other site
548473005265	dimerization interface [polypeptide binding]; other site
548473005266	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548473005267	DNA binding site [nucleotide binding]
548473005268	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
548473005269	HAMP domain; Region: HAMP; pfam00672
548473005270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548473005271	dimer interface [polypeptide binding]; other site
548473005272	phosphorylation site [posttranslational modification]
548473005273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473005274	ATP binding site [chemical binding]; other site
548473005275	Mg2+ binding site [ion binding]; other site
548473005276	G-X-G motif; other site
548473005277	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
548473005278	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
548473005279	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
548473005280	TPP-binding site [chemical binding]; other site
548473005281	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
548473005282	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
548473005283	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
548473005284	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
548473005285	E3 interaction surface; other site
548473005286	lipoyl attachment site [posttranslational modification]; other site
548473005287	e3 binding domain; Region: E3_binding; pfam02817
548473005288	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
548473005289	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
548473005290	active site
548473005291	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
548473005292	active site
548473005293	MoxR-like ATPases [General function prediction only]; Region: COG0714
548473005294	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473005295	Walker A motif; other site
548473005296	ATP binding site [chemical binding]; other site
548473005297	Walker B motif; other site
548473005298	arginine finger; other site
548473005299	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
548473005300	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
548473005301	metal ion-dependent adhesion site (MIDAS); other site
548473005302	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
548473005303	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
548473005304	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
548473005305	acylphosphatase; Provisional; Region: PRK14431
548473005306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699
548473005307	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
548473005308	DNA-binding site [nucleotide binding]; DNA binding site
548473005309	RNA-binding motif; other site
548473005310	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
548473005311	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
548473005312	active site
548473005313	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548473005314	substrate binding site [chemical binding]; other site
548473005315	catalytic residues [active]
548473005316	dimer interface [polypeptide binding]; other site
548473005317	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
548473005318	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
548473005319	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548473005320	catalytic residue [active]
548473005321	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
548473005322	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
548473005323	metal binding site [ion binding]; metal-binding site
548473005324	dimer interface [polypeptide binding]; other site
548473005325	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
548473005326	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
548473005327	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
548473005328	active site
548473005329	trimer interface [polypeptide binding]; other site
548473005330	substrate binding site [chemical binding]; other site
548473005331	CoA binding site [chemical binding]; other site
548473005332	dihydrodipicolinate reductase; Provisional; Region: PRK00048
548473005333	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
548473005334	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
548473005335	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
548473005336	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
548473005337	dimer interface [polypeptide binding]; other site
548473005338	active site
548473005339	catalytic residue [active]
548473005340	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
548473005341	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
548473005342	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
548473005343	aspartate kinase; Reviewed; Region: PRK06635
548473005344	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
548473005345	putative nucleotide binding site [chemical binding]; other site
548473005346	putative catalytic residues [active]
548473005347	putative Mg ion binding site [ion binding]; other site
548473005348	putative aspartate binding site [chemical binding]; other site
548473005349	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
548473005350	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
548473005351	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
548473005352	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548473005353	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548473005354	ABC transporter; Region: ABC_tran_2; pfam12848
548473005355	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548473005356	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
548473005357	S1 domain; Region: S1_2; pfam13509
548473005358	phosphate binding protein; Region: ptsS_2; TIGR02136
548473005359	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
548473005360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473005361	dimer interface [polypeptide binding]; other site
548473005362	conserved gate region; other site
548473005363	ABC-ATPase subunit interface; other site
548473005364	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
548473005365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473005366	dimer interface [polypeptide binding]; other site
548473005367	conserved gate region; other site
548473005368	putative PBP binding loops; other site
548473005369	ABC-ATPase subunit interface; other site
548473005370	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
548473005371	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
548473005372	Walker A/P-loop; other site
548473005373	ATP binding site [chemical binding]; other site
548473005374	Q-loop/lid; other site
548473005375	ABC transporter signature motif; other site
548473005376	Walker B; other site
548473005377	D-loop; other site
548473005378	H-loop/switch region; other site
548473005379	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
548473005380	PhoU domain; Region: PhoU; pfam01895
548473005381	PhoU domain; Region: PhoU; pfam01895
548473005382	oligoendopeptidase F; Region: pepF; TIGR00181
548473005383	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
548473005384	active site
548473005385	Zn binding site [ion binding]; other site
548473005386	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
548473005387	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
548473005388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473005389	dimer interface [polypeptide binding]; other site
548473005390	conserved gate region; other site
548473005391	putative PBP binding loops; other site
548473005392	ABC-ATPase subunit interface; other site
548473005393	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
548473005394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473005395	dimer interface [polypeptide binding]; other site
548473005396	conserved gate region; other site
548473005397	putative PBP binding loops; other site
548473005398	ABC-ATPase subunit interface; other site
548473005399	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473005400	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
548473005401	Walker A/P-loop; other site
548473005402	ATP binding site [chemical binding]; other site
548473005403	Q-loop/lid; other site
548473005404	ABC transporter signature motif; other site
548473005405	Walker B; other site
548473005406	D-loop; other site
548473005407	H-loop/switch region; other site
548473005408	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
548473005409	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473005410	Walker A/P-loop; other site
548473005411	ATP binding site [chemical binding]; other site
548473005412	Q-loop/lid; other site
548473005413	ABC transporter signature motif; other site
548473005414	Walker B; other site
548473005415	D-loop; other site
548473005416	H-loop/switch region; other site
548473005417	SWIM zinc finger; Region: SWIM; pfam04434
548473005418	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
548473005419	FemAB family; Region: FemAB; pfam02388
548473005420	FemAB family; Region: FemAB; pfam02388
548473005421	FlxA-like protein; Region: FlxA; pfam14282
548473005422	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
548473005423	substrate binding site [chemical binding]; other site
548473005424	active site
548473005425	catalytic residues [active]
548473005426	heterodimer interface [polypeptide binding]; other site
548473005427	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
548473005428	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
548473005429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473005430	catalytic residue [active]
548473005431	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
548473005432	active site
548473005433	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
548473005434	active site
548473005435	ribulose/triose binding site [chemical binding]; other site
548473005436	phosphate binding site [ion binding]; other site
548473005437	substrate (anthranilate) binding pocket [chemical binding]; other site
548473005438	product (indole) binding pocket [chemical binding]; other site
548473005439	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
548473005440	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
548473005441	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
548473005442	Glutamine amidotransferase class-I; Region: GATase; pfam00117
548473005443	glutamine binding [chemical binding]; other site
548473005444	catalytic triad [active]
548473005445	anthranilate synthase component I; Provisional; Region: PRK13567
548473005446	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
548473005447	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
548473005448	T-box leader; HMPREF0772_nc10030
548473005449	T-box leader; HMPREF0772_nc10031
548473005450	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
548473005451	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
548473005452	putative oligomer interface [polypeptide binding]; other site
548473005453	putative active site [active]
548473005454	metal binding site [ion binding]; metal-binding site
548473005455	prephenate dehydrogenase; Validated; Region: PRK06545
548473005456	prephenate dehydrogenase; Validated; Region: PRK08507
548473005457	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
548473005458	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
548473005459	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
548473005460	active site
548473005461	DNA binding site [nucleotide binding]
548473005462	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
548473005463	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
548473005464	active site 1 [active]
548473005465	dimer interface [polypeptide binding]; other site
548473005466	hexamer interface [polypeptide binding]; other site
548473005467	active site 2 [active]
548473005468	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473005469	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473005470	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
548473005471	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473005472	Transcriptional regulator [Transcription]; Region: LytR; COG1316
548473005473	methionine sulfoxide reductase A; Provisional; Region: PRK14054
548473005474	Predicted integral membrane protein [Function unknown]; Region: COG0392
548473005475	Uncharacterized conserved protein [Function unknown]; Region: COG2898
548473005476	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
548473005477	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
548473005478	Domain of unknown function DUF20; Region: UPF0118; pfam01594
548473005479	CAT RNA binding domain; Region: CAT_RBD; smart01061
548473005480	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
548473005481	PRD domain; Region: PRD; pfam00874
548473005482	PRD domain; Region: PRD; pfam00874
548473005483	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
548473005484	amino acid carrier protein; Region: agcS; TIGR00835
548473005485	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
548473005486	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
548473005487	CAP-like domain; other site
548473005488	active site
548473005489	primary dimer interface [polypeptide binding]; other site
548473005490	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
548473005491	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
548473005492	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473005493	ATP binding site [chemical binding]; other site
548473005494	Mg2+ binding site [ion binding]; other site
548473005495	G-X-G motif; other site
548473005496	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
548473005497	anchoring element; other site
548473005498	dimer interface [polypeptide binding]; other site
548473005499	ATP binding site [chemical binding]; other site
548473005500	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
548473005501	active site
548473005502	putative metal-binding site [ion binding]; other site
548473005503	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
548473005504	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
548473005505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
548473005506	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
548473005507	active site
548473005508	aconitate hydratase; Validated; Region: PRK09277
548473005509	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
548473005510	substrate binding site [chemical binding]; other site
548473005511	ligand binding site [chemical binding]; other site
548473005512	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
548473005513	substrate binding site [chemical binding]; other site
548473005514	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
548473005515	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
548473005516	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954
548473005517	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
548473005518	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
548473005519	Walker A/P-loop; other site
548473005520	ATP binding site [chemical binding]; other site
548473005521	Q-loop/lid; other site
548473005522	Walker B; other site
548473005523	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
548473005524	ABC transporter signature motif; other site
548473005525	Walker B; other site
548473005526	D-loop; other site
548473005527	H-loop/switch region; other site
548473005528	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
548473005529	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
548473005530	active site
548473005531	metal binding site [ion binding]; metal-binding site
548473005532	DNA binding site [nucleotide binding]
548473005533	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
548473005534	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
548473005535	Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536
548473005536	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
548473005537	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
548473005538	TPP-binding site [chemical binding]; other site
548473005539	dimer interface [polypeptide binding]; other site
548473005540	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
548473005541	PYR/PP interface [polypeptide binding]; other site
548473005542	dimer interface [polypeptide binding]; other site
548473005543	TPP binding site [chemical binding]; other site
548473005544	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
548473005545	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
548473005546	LexA repressor; Validated; Region: PRK00215
548473005547	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548473005548	putative DNA binding site [nucleotide binding]; other site
548473005549	putative Zn2+ binding site [ion binding]; other site
548473005550	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
548473005551	Catalytic site [active]
548473005552	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
548473005553	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
548473005554	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
548473005555	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
548473005556	active site
548473005557	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
548473005558	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
548473005559	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
548473005560	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
548473005561	tetramer interface [polypeptide binding]; other site
548473005562	heme binding pocket [chemical binding]; other site
548473005563	NADPH binding site [chemical binding]; other site
548473005564	lysine transporter; Provisional; Region: PRK10836
548473005565	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473005566	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
548473005567	active site
548473005568	motif I; other site
548473005569	motif II; other site
548473005570	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
548473005571	homoserine kinase; Provisional; Region: PRK01212
548473005572	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
548473005573	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
548473005574	threonine synthase; Reviewed; Region: PRK06721
548473005575	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
548473005576	homodimer interface [polypeptide binding]; other site
548473005577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473005578	catalytic residue [active]
548473005579	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
548473005580	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
548473005581	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
548473005582	aspartate kinase; Reviewed; Region: PRK09034
548473005583	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
548473005584	putative catalytic residues [active]
548473005585	putative nucleotide binding site [chemical binding]; other site
548473005586	putative aspartate binding site [chemical binding]; other site
548473005587	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
548473005588	allosteric regulatory residue; other site
548473005589	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
548473005590	AAA domain; Region: AAA_11; pfam13086
548473005591	Staphylococcal nuclease homologues; Region: SNc; smart00318
548473005592	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
548473005593	Catalytic site; other site
548473005594	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
548473005595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473005596	active site
548473005597	phosphorylation site [posttranslational modification]
548473005598	intermolecular recognition site; other site
548473005599	dimerization interface [polypeptide binding]; other site
548473005600	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
548473005601	DNA binding residues [nucleotide binding]
548473005602	dimerization interface [polypeptide binding]; other site
548473005603	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
548473005604	Histidine kinase; Region: HisKA_3; pfam07730
548473005605	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
548473005606	ATP binding site [chemical binding]; other site
548473005607	Mg2+ binding site [ion binding]; other site
548473005608	G-X-G motif; other site
548473005609	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
548473005610	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
548473005611	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
548473005612	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
548473005613	Walker A/P-loop; other site
548473005614	ATP binding site [chemical binding]; other site
548473005615	Q-loop/lid; other site
548473005616	ABC transporter signature motif; other site
548473005617	Walker B; other site
548473005618	D-loop; other site
548473005619	H-loop/switch region; other site
548473005620	potential frameshift: common BLAST hit: gi|49483510|ref|YP_040734.1| cardiolipin synthase
548473005621	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
548473005622	putative active site [active]
548473005623	catalytic site [active]
548473005624	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
548473005625	PLD-like domain; Region: PLDc_2; pfam13091
548473005626	putative active site [active]
548473005627	catalytic site [active]
548473005628	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
548473005629	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
548473005630	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
548473005631	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
548473005632	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548473005633	catalytic residue [active]
548473005634	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
548473005635	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
548473005636	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
548473005637	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
548473005638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
548473005639	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473005640	Helix-turn-helix domain; Region: HTH_38; pfam13936
548473005641	Integrase core domain; Region: rve; pfam00665
548473005642	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
548473005643	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
548473005644	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
548473005645	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
548473005646	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
548473005647	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
548473005648	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
548473005649	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
548473005650	DNA binding residues [nucleotide binding]
548473005651	putative dimer interface [polypeptide binding]; other site
548473005652	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
548473005653	Aluminium resistance protein; Region: Alum_res; pfam06838
548473005654	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
548473005655	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
548473005656	HflX GTPase family; Region: HflX; cd01878
548473005657	G1 box; other site
548473005658	GTP/Mg2+ binding site [chemical binding]; other site
548473005659	Switch I region; other site
548473005660	G2 box; other site
548473005661	G3 box; other site
548473005662	Switch II region; other site
548473005663	G4 box; other site
548473005664	G5 box; other site
548473005665	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
548473005666	catalytic residues [active]
548473005667	dimer interface [polypeptide binding]; other site
548473005668	bacterial Hfq-like; Region: Hfq; cd01716
548473005669	hexamer interface [polypeptide binding]; other site
548473005670	Sm1 motif; other site
548473005671	RNA binding site [nucleotide binding]; other site
548473005672	Sm2 motif; other site
548473005673	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
548473005674	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
548473005675	potential frameshift: common BLAST hit: gi|49483465|ref|YP_040689.1| hydrolase
548473005676	Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209
548473005677	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
548473005678	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
548473005679	PGAP1-like protein; Region: PGAP1; pfam07819
548473005680	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
548473005681	glycerol kinase; Provisional; Region: glpK; PRK00047
548473005682	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
548473005683	N- and C-terminal domain interface [polypeptide binding]; other site
548473005684	active site
548473005685	MgATP binding site [chemical binding]; other site
548473005686	catalytic site [active]
548473005687	metal binding site [ion binding]; metal-binding site
548473005688	glycerol binding site [chemical binding]; other site
548473005689	homotetramer interface [polypeptide binding]; other site
548473005690	homodimer interface [polypeptide binding]; other site
548473005691	FBP binding site [chemical binding]; other site
548473005692	protein IIAGlc interface [polypeptide binding]; other site
548473005693	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
548473005694	amphipathic channel; other site
548473005695	Asn-Pro-Ala signature motifs; other site
548473005696	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
548473005697	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
548473005698	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
548473005699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473005700	ATP binding site [chemical binding]; other site
548473005701	Mg2+ binding site [ion binding]; other site
548473005702	G-X-G motif; other site
548473005703	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
548473005704	ATP binding site [chemical binding]; other site
548473005705	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
548473005706	MutS domain I; Region: MutS_I; pfam01624
548473005707	MutS domain II; Region: MutS_II; pfam05188
548473005708	MutS domain III; Region: MutS_III; pfam05192
548473005709	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
548473005710	Walker A/P-loop; other site
548473005711	ATP binding site [chemical binding]; other site
548473005712	Q-loop/lid; other site
548473005713	ABC transporter signature motif; other site
548473005714	Walker B; other site
548473005715	D-loop; other site
548473005716	H-loop/switch region; other site
548473005717	Predicted membrane protein [Function unknown]; Region: COG4732
548473005718	Predicted membrane protein [Function unknown]; Region: COG4550
548473005719	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
548473005720	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
548473005721	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473005722	FeS/SAM binding site; other site
548473005723	TRAM domain; Region: TRAM; pfam01938
548473005724	Uncharacterized conserved protein [Function unknown]; Region: COG0011
548473005725	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
548473005726	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
548473005727	TPP-binding site [chemical binding]; other site
548473005728	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
548473005729	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
548473005730	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
548473005731	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
548473005732	dimer interface [polypeptide binding]; other site
548473005733	PYR/PP interface [polypeptide binding]; other site
548473005734	TPP binding site [chemical binding]; other site
548473005735	substrate binding site [chemical binding]; other site
548473005736	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
548473005737	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
548473005738	putative active site [active]
548473005739	metal binding site [ion binding]; metal-binding site
548473005740	homodimer binding site [polypeptide binding]; other site
548473005741	phosphodiesterase; Provisional; Region: PRK12704
548473005742	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548473005743	Zn2+ binding site [ion binding]; other site
548473005744	Mg2+ binding site [ion binding]; other site
548473005745	recombinase A; Provisional; Region: recA; PRK09354
548473005746	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
548473005747	hexamer interface [polypeptide binding]; other site
548473005748	Walker A motif; other site
548473005749	ATP binding site [chemical binding]; other site
548473005750	Walker B motif; other site
548473005751	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
548473005752	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
548473005753	putative MPT binding site; other site
548473005754	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
548473005755	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
548473005756	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
548473005757	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473005758	non-specific DNA binding site [nucleotide binding]; other site
548473005759	salt bridge; other site
548473005760	sequence-specific DNA binding site [nucleotide binding]; other site
548473005761	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
548473005762	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
548473005763	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
548473005764	classical (c) SDRs; Region: SDR_c; cd05233
548473005765	NAD(P) binding site [chemical binding]; other site
548473005766	active site
548473005767	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
548473005768	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
548473005769	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
548473005770	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
548473005771	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
548473005772	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
548473005773	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
548473005774	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
548473005775	DNA-binding site [nucleotide binding]; DNA binding site
548473005776	UTRA domain; Region: UTRA; pfam07702
548473005777	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
548473005778	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
548473005779	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
548473005780	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
548473005781	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
548473005782	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
548473005783	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
548473005784	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
548473005785	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
548473005786	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
548473005787	RNase E interface [polypeptide binding]; other site
548473005788	trimer interface [polypeptide binding]; other site
548473005789	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
548473005790	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
548473005791	RNase E interface [polypeptide binding]; other site
548473005792	trimer interface [polypeptide binding]; other site
548473005793	active site
548473005794	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
548473005795	putative nucleic acid binding region [nucleotide binding]; other site
548473005796	G-X-X-G motif; other site
548473005797	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
548473005798	RNA binding site [nucleotide binding]; other site
548473005799	domain interface; other site
548473005800	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
548473005801	16S/18S rRNA binding site [nucleotide binding]; other site
548473005802	S13e-L30e interaction site [polypeptide binding]; other site
548473005803	25S rRNA binding site [nucleotide binding]; other site
548473005804	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
548473005805	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
548473005806	active site
548473005807	Riboflavin kinase; Region: Flavokinase; smart00904
548473005808	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
548473005809	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
548473005810	RNA binding site [nucleotide binding]; other site
548473005811	active site
548473005812	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
548473005813	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
548473005814	translation initiation factor IF-2; Region: IF-2; TIGR00487
548473005815	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
548473005816	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
548473005817	G1 box; other site
548473005818	putative GEF interaction site [polypeptide binding]; other site
548473005819	GTP/Mg2+ binding site [chemical binding]; other site
548473005820	Switch I region; other site
548473005821	G2 box; other site
548473005822	G3 box; other site
548473005823	Switch II region; other site
548473005824	G4 box; other site
548473005825	G5 box; other site
548473005826	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
548473005827	Translation-initiation factor 2; Region: IF-2; pfam11987
548473005828	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
548473005829	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
548473005830	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
548473005831	putative RNA binding cleft [nucleotide binding]; other site
548473005832	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
548473005833	NusA N-terminal domain; Region: NusA_N; pfam08529
548473005834	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
548473005835	RNA binding site [nucleotide binding]; other site
548473005836	homodimer interface [polypeptide binding]; other site
548473005837	NusA-like KH domain; Region: KH_5; pfam13184
548473005838	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
548473005839	G-X-X-G motif; other site
548473005840	ribosome maturation protein RimP; Reviewed; Region: PRK00092
548473005841	Sm and related proteins; Region: Sm_like; cl00259
548473005842	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
548473005843	putative oligomer interface [polypeptide binding]; other site
548473005844	putative RNA binding site [nucleotide binding]; other site
548473005845	DNA polymerase III PolC; Validated; Region: polC; PRK00448
548473005846	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
548473005847	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
548473005848	generic binding surface II; other site
548473005849	generic binding surface I; other site
548473005850	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
548473005851	active site
548473005852	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
548473005853	active site
548473005854	catalytic site [active]
548473005855	substrate binding site [chemical binding]; other site
548473005856	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
548473005857	prolyl-tRNA synthetase; Provisional; Region: PRK09194
548473005858	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
548473005859	dimer interface [polypeptide binding]; other site
548473005860	motif 1; other site
548473005861	active site
548473005862	motif 2; other site
548473005863	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
548473005864	putative deacylase active site [active]
548473005865	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
548473005866	active site
548473005867	motif 3; other site
548473005868	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
548473005869	anticodon binding site; other site
548473005870	RIP metalloprotease RseP; Region: TIGR00054
548473005871	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
548473005872	active site
548473005873	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
548473005874	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
548473005875	protein binding site [polypeptide binding]; other site
548473005876	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
548473005877	putative substrate binding region [chemical binding]; other site
548473005878	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
548473005879	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
548473005880	potential frameshift: common BLAST hit: gi|379020970|ref|YP_005297632.1| undecaprenyl pyrophosphate synthetase
548473005881	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
548473005882	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
548473005883	putative FPP binding hydrophobic cleft; other site
548473005884	dimer interface [polypeptide binding]; other site
548473005885	putative IPP diphosphate binding site; other site
548473005886	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
548473005887	catalytic residue [active]
548473005888	putative FPP diphosphate  binding site; other site
548473005889	ribosome recycling factor; Reviewed; Region: frr; PRK00083
548473005890	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
548473005891	hinge region; other site
548473005892	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
548473005893	putative nucleotide binding site [chemical binding]; other site
548473005894	uridine monophosphate binding site [chemical binding]; other site
548473005895	homohexameric interface [polypeptide binding]; other site
548473005896	elongation factor Ts; Provisional; Region: tsf; PRK09377
548473005897	UBA/TS-N domain; Region: UBA; pfam00627
548473005898	Elongation factor TS; Region: EF_TS; pfam00889
548473005899	Elongation factor TS; Region: EF_TS; pfam00889
548473005900	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
548473005901	rRNA interaction site [nucleotide binding]; other site
548473005902	S8 interaction site; other site
548473005903	putative laminin-1 binding site; other site
548473005904	transcriptional repressor CodY; Validated; Region: PRK04158
548473005905	CodY GAF-like domain; Region: CodY; pfam06018
548473005906	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
548473005907	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
548473005908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473005909	Walker A motif; other site
548473005910	ATP binding site [chemical binding]; other site
548473005911	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
548473005912	Walker B motif; other site
548473005913	arginine finger; other site
548473005914	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
548473005915	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
548473005916	active site
548473005917	HslU subunit interaction site [polypeptide binding]; other site
548473005918	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
548473005919	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
548473005920	active site
548473005921	DNA binding site [nucleotide binding]
548473005922	Int/Topo IB signature motif; other site
548473005923	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
548473005924	Glucose inhibited division protein A; Region: GIDA; pfam01134
548473005925	DNA topoisomerase I; Validated; Region: PRK05582
548473005926	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
548473005927	active site
548473005928	interdomain interaction site; other site
548473005929	putative metal-binding site [ion binding]; other site
548473005930	nucleotide binding site [chemical binding]; other site
548473005931	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
548473005932	domain I; other site
548473005933	DNA binding groove [nucleotide binding]
548473005934	phosphate binding site [ion binding]; other site
548473005935	domain II; other site
548473005936	domain III; other site
548473005937	nucleotide binding site [chemical binding]; other site
548473005938	catalytic site [active]
548473005939	domain IV; other site
548473005940	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
548473005941	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
548473005942	DNA protecting protein DprA; Region: dprA; TIGR00732
548473005943	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
548473005944	potential frameshift: common BLAST hit: gi|49483411|ref|YP_040635.1| FemAB family protein
548473005945	FemAB family; Region: FemAB; pfam02388
548473005946	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
548473005947	FemAB family; Region: FemAB; pfam02388
548473005948	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
548473005949	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
548473005950	CHAP domain; Region: CHAP; pfam05257
548473005951	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
548473005952	CoA binding domain; Region: CoA_binding; pfam02629
548473005953	CoA-ligase; Region: Ligase_CoA; pfam00549
548473005954	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
548473005955	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
548473005956	CoA-ligase; Region: Ligase_CoA; pfam00549
548473005957	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
548473005958	RNA/DNA hybrid binding site [nucleotide binding]; other site
548473005959	active site
548473005960	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
548473005961	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
548473005962	GTP/Mg2+ binding site [chemical binding]; other site
548473005963	G4 box; other site
548473005964	G5 box; other site
548473005965	G1 box; other site
548473005966	Switch I region; other site
548473005967	G2 box; other site
548473005968	G3 box; other site
548473005969	Switch II region; other site
548473005970	Predicted membrane protein [Function unknown]; Region: COG4485
548473005971	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
548473005972	Ribosomal protein L19 leader; HMPREF0772_nc10032
548473005973	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
548473005974	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
548473005975	RimM N-terminal domain; Region: RimM; pfam01782
548473005976	PRC-barrel domain; Region: PRC; pfam05239
548473005977	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
548473005978	signal recognition particle protein; Provisional; Region: PRK10867
548473005979	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
548473005980	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
548473005981	P loop; other site
548473005982	GTP binding site [chemical binding]; other site
548473005983	Signal peptide binding domain; Region: SRP_SPB; pfam02978
548473005984	putative DNA-binding protein; Validated; Region: PRK00118
548473005985	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
548473005986	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
548473005987	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
548473005988	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
548473005989	P loop; other site
548473005990	GTP binding site [chemical binding]; other site
548473005991	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
548473005992	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
548473005993	Walker A/P-loop; other site
548473005994	ATP binding site [chemical binding]; other site
548473005995	Q-loop/lid; other site
548473005996	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
548473005997	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
548473005998	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
548473005999	ABC transporter signature motif; other site
548473006000	Walker B; other site
548473006001	D-loop; other site
548473006002	H-loop/switch region; other site
548473006003	ribonuclease III; Reviewed; Region: rnc; PRK00102
548473006004	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
548473006005	dimerization interface [polypeptide binding]; other site
548473006006	active site
548473006007	metal binding site [ion binding]; metal-binding site
548473006008	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
548473006009	dsRNA binding site [nucleotide binding]; other site
548473006010	acyl carrier protein; Provisional; Region: acpP; PRK00982
548473006011	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
548473006012	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
548473006013	NAD(P) binding site [chemical binding]; other site
548473006014	homotetramer interface [polypeptide binding]; other site
548473006015	homodimer interface [polypeptide binding]; other site
548473006016	active site
548473006017	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
548473006018	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
548473006019	putative phosphate acyltransferase; Provisional; Region: PRK05331
548473006020	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
548473006021	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
548473006022	active site 2 [active]
548473006023	active site 1 [active]
548473006024	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
548473006025	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
548473006026	generic binding surface II; other site
548473006027	ssDNA binding site; other site
548473006028	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473006029	ATP binding site [chemical binding]; other site
548473006030	putative Mg++ binding site [ion binding]; other site
548473006031	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548473006032	nucleotide binding region [chemical binding]; other site
548473006033	ATP-binding site [chemical binding]; other site
548473006034	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
548473006035	DAK2 domain; Region: Dak2; pfam02734
548473006036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
548473006037	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
548473006038	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
548473006039	Thiamine pyrophosphokinase; Region: TPK; cd07995
548473006040	active site
548473006041	dimerization interface [polypeptide binding]; other site
548473006042	thiamine binding site [chemical binding]; other site
548473006043	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
548473006044	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
548473006045	substrate binding site [chemical binding]; other site
548473006046	hexamer interface [polypeptide binding]; other site
548473006047	metal binding site [ion binding]; metal-binding site
548473006048	Predicted GTPases [General function prediction only]; Region: COG1162
548473006049	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
548473006050	RNA binding site [nucleotide binding]; other site
548473006051	homodimer interface [polypeptide binding]; other site
548473006052	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
548473006053	GTPase/Zn-binding domain interface [polypeptide binding]; other site
548473006054	GTP/Mg2+ binding site [chemical binding]; other site
548473006055	G4 box; other site
548473006056	G5 box; other site
548473006057	G1 box; other site
548473006058	Switch I region; other site
548473006059	G2 box; other site
548473006060	G3 box; other site
548473006061	Switch II region; other site
548473006062	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
548473006063	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
548473006064	active site
548473006065	ATP binding site [chemical binding]; other site
548473006066	substrate binding site [chemical binding]; other site
548473006067	activation loop (A-loop); other site
548473006068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
548473006069	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
548473006070	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
548473006071	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
548473006072	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
548473006073	Protein phosphatase 2C; Region: PP2C; pfam00481
548473006074	active site
548473006075	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
548473006076	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473006077	FeS/SAM binding site; other site
548473006078	16S rRNA methyltransferase B; Provisional; Region: PRK14902
548473006079	NusB family; Region: NusB; pfam01029
548473006080	putative RNA binding site [nucleotide binding]; other site
548473006081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473006082	S-adenosylmethionine binding site [chemical binding]; other site
548473006083	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
548473006084	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
548473006085	putative active site [active]
548473006086	substrate binding site [chemical binding]; other site
548473006087	putative cosubstrate binding site; other site
548473006088	catalytic site [active]
548473006089	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
548473006090	substrate binding site [chemical binding]; other site
548473006091	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
548473006092	active site
548473006093	catalytic residues [active]
548473006094	metal binding site [ion binding]; metal-binding site
548473006095	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
548473006096	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
548473006097	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473006098	ATP binding site [chemical binding]; other site
548473006099	putative Mg++ binding site [ion binding]; other site
548473006100	helicase superfamily c-terminal domain; Region: HELICc; smart00490
548473006101	nucleotide binding region [chemical binding]; other site
548473006102	ATP-binding site [chemical binding]; other site
548473006103	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
548473006104	Flavoprotein; Region: Flavoprotein; pfam02441
548473006105	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
548473006106	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
548473006107	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
548473006108	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
548473006109	catalytic site [active]
548473006110	G-X2-G-X-G-K; other site
548473006111	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
548473006112	Domain of unknown function (DUF814); Region: DUF814; pfam05670
548473006113	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
548473006114	dimer interface [polypeptide binding]; other site
548473006115	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548473006116	active site
548473006117	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
548473006118	active site
548473006119	dimer interface [polypeptide binding]; other site
548473006120	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
548473006121	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548473006122	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
548473006123	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
548473006124	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548473006125	ATP-grasp domain; Region: ATP-grasp_4; cl17255
548473006126	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
548473006127	IMP binding site; other site
548473006128	dimer interface [polypeptide binding]; other site
548473006129	interdomain contacts; other site
548473006130	partial ornithine binding site; other site
548473006131	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
548473006132	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
548473006133	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
548473006134	catalytic site [active]
548473006135	subunit interface [polypeptide binding]; other site
548473006136	dihydroorotase; Validated; Region: pyrC; PRK09357
548473006137	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
548473006138	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
548473006139	active site
548473006140	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
548473006141	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
548473006142	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
548473006143	uracil transporter; Provisional; Region: PRK10720
548473006144	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
548473006145	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
548473006146	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
548473006147	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548473006148	RNA binding surface [nucleotide binding]; other site
548473006149	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
548473006150	active site
548473006151	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
548473006152	lipoprotein signal peptidase; Provisional; Region: PRK14787
548473006153	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
548473006154	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
548473006155	active site
548473006156	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473006157	Helix-turn-helix domain; Region: HTH_38; pfam13936
548473006158	Integrase core domain; Region: rve; pfam00665
548473006159	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
548473006160	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
548473006161	HIGH motif; other site
548473006162	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
548473006163	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
548473006164	active site
548473006165	KMSKS motif; other site
548473006166	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
548473006167	tRNA binding surface [nucleotide binding]; other site
548473006168	anticodon binding site; other site
548473006169	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
548473006170	T-box leader; HMPREF0772_nc10033
548473006171	DivIVA protein; Region: DivIVA; pfam05103
548473006172	DivIVA domain; Region: DivI1A_domain; TIGR03544
548473006173	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
548473006174	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
548473006175	RNA binding surface [nucleotide binding]; other site
548473006176	YGGT family; Region: YGGT; pfam02325
548473006177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
548473006178	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
548473006179	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
548473006180	catalytic residue [active]
548473006181	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
548473006182	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
548473006183	cell division protein FtsZ; Validated; Region: PRK09330
548473006184	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
548473006185	nucleotide binding site [chemical binding]; other site
548473006186	SulA interaction site; other site
548473006187	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
548473006188	Cell division protein FtsA; Region: FtsA; smart00842
548473006189	Cell division protein FtsA; Region: FtsA; pfam14450
548473006190	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
548473006191	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
548473006192	Cell division protein FtsQ; Region: FtsQ; pfam03799
548473006193	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
548473006194	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
548473006195	NAD binding site [chemical binding]; other site
548473006196	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548473006197	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548473006198	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
548473006199	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
548473006200	Mg++ binding site [ion binding]; other site
548473006201	putative catalytic motif [active]
548473006202	putative substrate binding site [chemical binding]; other site
548473006203	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
548473006204	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
548473006205	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
548473006206	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
548473006207	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
548473006208	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
548473006209	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
548473006210	MraW methylase family; Region: Methyltransf_5; pfam01795
548473006211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
548473006212	MraZ protein; Region: MraZ; pfam02381
548473006213	MraZ protein; Region: MraZ; pfam02381
548473006214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
548473006215	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
548473006216	hypothetical protein; Provisional; Region: PRK13688
548473006217	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
548473006218	Coenzyme A binding pocket [chemical binding]; other site
548473006219	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
548473006220	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473006221	motif II; other site
548473006222	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
548473006223	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
548473006224	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
548473006225	gating phenylalanine in ion channel; other site
548473006226	Predicted membrane protein [Function unknown]; Region: COG1288
548473006227	Predicted membrane protein [Function unknown]; Region: COG1288
548473006228	carbamate kinase; Reviewed; Region: PRK12686
548473006229	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
548473006230	putative substrate binding site [chemical binding]; other site
548473006231	nucleotide binding site [chemical binding]; other site
548473006232	nucleotide binding site [chemical binding]; other site
548473006233	homodimer interface [polypeptide binding]; other site
548473006234	ornithine carbamoyltransferase; Provisional; Region: PRK04284
548473006235	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
548473006236	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
548473006237	superantigen-like protein; Reviewed; Region: PRK13043
548473006238	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473006239	superantigen-like protein; Reviewed; Region: PRK13349
548473006240	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473006241	superantigen-like protein; Reviewed; Region: PRK13350
548473006242	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
548473006243	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473006244	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473006245	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
548473006246	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473006247	beta-channel forming cytolysin; Region: hlyII; TIGR01002
548473006248	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
548473006249	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
548473006250	formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033
548473006251	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
548473006252	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
548473006253	active site
548473006254	metal binding site [ion binding]; metal-binding site
548473006255	homotetramer interface [polypeptide binding]; other site
548473006256	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
548473006257	active site
548473006258	dimerization interface [polypeptide binding]; other site
548473006259	glutamate racemase; Provisional; Region: PRK00865
548473006260	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
548473006261	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
548473006262	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
548473006263	L-aspartate oxidase; Provisional; Region: PRK06175
548473006264	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
548473006265	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
548473006266	putative Iron-sulfur protein interface [polypeptide binding]; other site
548473006267	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
548473006268	proximal heme binding site [chemical binding]; other site
548473006269	distal heme binding site [chemical binding]; other site
548473006270	putative dimer interface [polypeptide binding]; other site
548473006271	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
548473006272	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
548473006273	GIY-YIG motif/motif A; other site
548473006274	active site
548473006275	catalytic site [active]
548473006276	putative DNA binding site [nucleotide binding]; other site
548473006277	metal binding site [ion binding]; metal-binding site
548473006278	UvrB/uvrC motif; Region: UVR; pfam02151
548473006279	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
548473006280	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
548473006281	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
548473006282	catalytic residues [active]
548473006283	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
548473006284	MutS domain III; Region: MutS_III; pfam05192
548473006285	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
548473006286	Walker A/P-loop; other site
548473006287	ATP binding site [chemical binding]; other site
548473006288	Q-loop/lid; other site
548473006289	ABC transporter signature motif; other site
548473006290	Walker B; other site
548473006291	D-loop; other site
548473006292	H-loop/switch region; other site
548473006293	Smr domain; Region: Smr; pfam01713
548473006294	hypothetical protein; Provisional; Region: PRK08609
548473006295	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
548473006296	active site
548473006297	primer binding site [nucleotide binding]; other site
548473006298	NTP  binding site [chemical binding]; other site
548473006299	metal binding triad [ion binding]; metal-binding site
548473006300	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
548473006301	active site
548473006302	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
548473006303	Colicin V production protein; Region: Colicin_V; pfam02674
548473006304	Cell division protein ZapA; Region: ZapA; cl01146
548473006305	ribonuclease HIII; Provisional; Region: PRK00996
548473006306	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
548473006307	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
548473006308	RNA/DNA hybrid binding site [nucleotide binding]; other site
548473006309	active site
548473006310	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
548473006311	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
548473006312	putative tRNA-binding site [nucleotide binding]; other site
548473006313	B3/4 domain; Region: B3_4; pfam03483
548473006314	tRNA synthetase B5 domain; Region: B5; smart00874
548473006315	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
548473006316	dimer interface [polypeptide binding]; other site
548473006317	motif 1; other site
548473006318	motif 3; other site
548473006319	motif 2; other site
548473006320	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
548473006321	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
548473006322	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
548473006323	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
548473006324	dimer interface [polypeptide binding]; other site
548473006325	motif 1; other site
548473006326	active site
548473006327	motif 2; other site
548473006328	motif 3; other site
548473006329	T-box leader; HMPREF0772_nc10034
548473006330	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
548473006331	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
548473006332	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
548473006333	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312
548473006334	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
548473006335	active site
548473006336	catalytic site [active]
548473006337	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
548473006338	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473006339	ABC-ATPase subunit  interface; other site
548473006340	dimer interface [polypeptide binding]; other site
548473006341	putative PBP binding regions; other site
548473006342	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
548473006343	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
548473006344	intersubunit interface [polypeptide binding]; other site
548473006345	heme uptake protein IsdC; Region: IsdC; TIGR03656
548473006346	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
548473006347	heme-binding site [chemical binding]; other site
548473006348	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
548473006349	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
548473006350	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
548473006351	heme-binding site [chemical binding]; other site
548473006352	heme uptake protein IsdB; Region: IsdB; TIGR03657
548473006353	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473006354	NEAr Transporter domain; Region: NEAT; smart00725
548473006355	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
548473006356	heme-binding site [chemical binding]; other site
548473006357	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
548473006358	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
548473006359	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
548473006360	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
548473006361	hypothetical protein; Provisional; Region: PRK13670
548473006362	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
548473006363	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
548473006364	active site
548473006365	(T/H)XGH motif; other site
548473006366	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
548473006367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473006368	S-adenosylmethionine binding site [chemical binding]; other site
548473006369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471
548473006370	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
548473006371	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
548473006372	putative active site [active]
548473006373	catalytic site [active]
548473006374	putative metal binding site [ion binding]; other site
548473006375	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
548473006376	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
548473006377	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
548473006378	Predicted membrane protein [Function unknown]; Region: COG2322
548473006379	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
548473006380	UbiA prenyltransferase family; Region: UbiA; pfam01040
548473006381	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
548473006382	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
548473006383	pyruvate carboxylase; Reviewed; Region: PRK12999
548473006384	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
548473006385	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
548473006386	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
548473006387	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
548473006388	active site
548473006389	catalytic residues [active]
548473006390	metal binding site [ion binding]; metal-binding site
548473006391	homodimer binding site [polypeptide binding]; other site
548473006392	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
548473006393	carboxyltransferase (CT) interaction site; other site
548473006394	biotinylation site [posttranslational modification]; other site
548473006395	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
548473006396	hypothetical protein; Provisional; Region: PRK13666
548473006397	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
548473006398	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
548473006399	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
548473006400	G1 box; other site
548473006401	putative GEF interaction site [polypeptide binding]; other site
548473006402	GTP/Mg2+ binding site [chemical binding]; other site
548473006403	Switch I region; other site
548473006404	G2 box; other site
548473006405	G3 box; other site
548473006406	Switch II region; other site
548473006407	G4 box; other site
548473006408	G5 box; other site
548473006409	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
548473006410	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
548473006411	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
548473006412	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
548473006413	active site
548473006414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
548473006415	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
548473006416	manganese transport protein MntH; Reviewed; Region: PRK00701
548473006417	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
548473006418	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
548473006419	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
548473006420	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
548473006421	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
548473006422	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
548473006423	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
548473006424	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
548473006425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473006426	dimer interface [polypeptide binding]; other site
548473006427	conserved gate region; other site
548473006428	putative PBP binding loops; other site
548473006429	ABC-ATPase subunit interface; other site
548473006430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473006431	putative PBP binding loops; other site
548473006432	dimer interface [polypeptide binding]; other site
548473006433	ABC-ATPase subunit interface; other site
548473006434	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
548473006435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473006436	Walker A/P-loop; other site
548473006437	ATP binding site [chemical binding]; other site
548473006438	Q-loop/lid; other site
548473006439	ABC transporter signature motif; other site
548473006440	Walker B; other site
548473006441	D-loop; other site
548473006442	H-loop/switch region; other site
548473006443	TOBE domain; Region: TOBE_2; pfam08402
548473006444	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548473006445	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473006446	non-specific DNA binding site [nucleotide binding]; other site
548473006447	salt bridge; other site
548473006448	sequence-specific DNA binding site [nucleotide binding]; other site
548473006449	Cupin domain; Region: Cupin_2; pfam07883
548473006450	hypothetical protein; Provisional; Region: PRK04387
548473006451	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
548473006452	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
548473006453	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473006454	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
548473006455	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
548473006456	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
548473006457	E3 interaction surface; other site
548473006458	lipoyl attachment site [posttranslational modification]; other site
548473006459	e3 binding domain; Region: E3_binding; pfam02817
548473006460	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
548473006461	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
548473006462	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
548473006463	alpha subunit interface [polypeptide binding]; other site
548473006464	TPP binding site [chemical binding]; other site
548473006465	heterodimer interface [polypeptide binding]; other site
548473006466	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
548473006467	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
548473006468	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
548473006469	TPP-binding site [chemical binding]; other site
548473006470	tetramer interface [polypeptide binding]; other site
548473006471	heterodimer interface [polypeptide binding]; other site
548473006472	phosphorylation loop region [posttranslational modification]
548473006473	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
548473006474	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
548473006475	active site
548473006476	catalytic residues [active]
548473006477	metal binding site [ion binding]; metal-binding site
548473006478	hypothetical protein; Provisional; Region: PRK13667
548473006479	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
548473006480	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
548473006481	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
548473006482	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
548473006483	TrkA-N domain; Region: TrkA_N; pfam02254
548473006484	TrkA-C domain; Region: TrkA_C; pfam02080
548473006485	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
548473006486	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
548473006487	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
548473006488	catalytic residues [active]
548473006489	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
548473006490	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
548473006491	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
548473006492	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
548473006493	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
548473006494	dimerization domain swap beta strand [polypeptide binding]; other site
548473006495	regulatory protein interface [polypeptide binding]; other site
548473006496	active site
548473006497	regulatory phosphorylation site [posttranslational modification]; other site
548473006498	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
548473006499	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
548473006500	putative RNA binding site [nucleotide binding]; other site
548473006501	Methyltransferase domain; Region: Methyltransf_26; pfam13659
548473006502	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
548473006503	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
548473006504	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548473006505	Walker A/P-loop; other site
548473006506	ATP binding site [chemical binding]; other site
548473006507	Q-loop/lid; other site
548473006508	ABC transporter signature motif; other site
548473006509	Walker B; other site
548473006510	D-loop; other site
548473006511	H-loop/switch region; other site
548473006512	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
548473006513	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
548473006514	Walker A/P-loop; other site
548473006515	ATP binding site [chemical binding]; other site
548473006516	Q-loop/lid; other site
548473006517	ABC transporter signature motif; other site
548473006518	Walker B; other site
548473006519	D-loop; other site
548473006520	H-loop/switch region; other site
548473006521	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
548473006522	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
548473006523	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
548473006524	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
548473006525	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
548473006526	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
548473006527	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
548473006528	purine monophosphate binding site [chemical binding]; other site
548473006529	dimer interface [polypeptide binding]; other site
548473006530	putative catalytic residues [active]
548473006531	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
548473006532	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
548473006533	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
548473006534	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
548473006535	active site
548473006536	substrate binding site [chemical binding]; other site
548473006537	cosubstrate binding site; other site
548473006538	catalytic site [active]
548473006539	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
548473006540	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
548473006541	dimerization interface [polypeptide binding]; other site
548473006542	putative ATP binding site [chemical binding]; other site
548473006543	amidophosphoribosyltransferase; Provisional; Region: PRK07272
548473006544	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
548473006545	active site
548473006546	tetramer interface [polypeptide binding]; other site
548473006547	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548473006548	active site
548473006549	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
548473006550	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
548473006551	dimerization interface [polypeptide binding]; other site
548473006552	ATP binding site [chemical binding]; other site
548473006553	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
548473006554	dimerization interface [polypeptide binding]; other site
548473006555	ATP binding site [chemical binding]; other site
548473006556	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
548473006557	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
548473006558	putative active site [active]
548473006559	catalytic triad [active]
548473006560	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
548473006561	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
548473006562	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
548473006563	ATP binding site [chemical binding]; other site
548473006564	active site
548473006565	substrate binding site [chemical binding]; other site
548473006566	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
548473006567	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
548473006568	NAD binding site [chemical binding]; other site
548473006569	ATP-grasp domain; Region: ATP-grasp; pfam02222
548473006570	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
548473006571	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
548473006572	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
548473006573	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
548473006574	homodimer interface [polypeptide binding]; other site
548473006575	NADP binding site [chemical binding]; other site
548473006576	substrate binding site [chemical binding]; other site
548473006577	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
548473006578	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
548473006579	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
548473006580	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
548473006581	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
548473006582	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
548473006583	D-pathway; other site
548473006584	Putative ubiquinol binding site [chemical binding]; other site
548473006585	Low-spin heme (heme b) binding site [chemical binding]; other site
548473006586	Putative water exit pathway; other site
548473006587	Binuclear center (heme o3/CuB) [ion binding]; other site
548473006588	K-pathway; other site
548473006589	Putative proton exit pathway; other site
548473006590	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
548473006591	Subunit I/III interface [polypeptide binding]; other site
548473006592	Subunit III/IV interface [polypeptide binding]; other site
548473006593	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
548473006594	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
548473006595	Beta-lactamase; Region: Beta-lactamase; pfam00144
548473006596	Transcriptional regulator [Transcription]; Region: LytR; COG1316
548473006597	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
548473006598	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473006599	Coenzyme A binding pocket [chemical binding]; other site
548473006600	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
548473006601	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
548473006602	amidase catalytic site [active]
548473006603	Zn binding residues [ion binding]; other site
548473006604	substrate binding site [chemical binding]; other site
548473006605	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
548473006606	Lysozyme subfamily 2; Region: LYZ2; smart00047
548473006607	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
548473006608	MarR family; Region: MarR; pfam01047
548473006609	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
548473006610	Acyltransferase family; Region: Acyl_transf_3; pfam01757
548473006611	aminotransferase A; Validated; Region: PRK07683
548473006612	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548473006613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473006614	homodimer interface [polypeptide binding]; other site
548473006615	catalytic residue [active]
548473006616	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
548473006617	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
548473006618	Staphostatin B; Region: Staphostatin_B; pfam09023
548473006619	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
548473006620	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
548473006621	substrate binding site [chemical binding]; other site
548473006622	oxyanion hole (OAH) forming residues; other site
548473006623	trimer interface [polypeptide binding]; other site
548473006624	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
548473006625	PGAP1-like protein; Region: PGAP1; pfam07819
548473006626	potential frameshift: common BLAST hit: gi|379020749|ref|YP_005297411.1| 2-oxoglutarate synthase subunit, 2-oxoacid-ferredoxin
548473006627	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
548473006628	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
548473006629	TPP-binding site; other site
548473006630	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
548473006631	dimer interface [polypeptide binding]; other site
548473006632	tetramer interface [polypeptide binding]; other site
548473006633	PYR/PP interface [polypeptide binding]; other site
548473006634	TPP binding site [chemical binding]; other site
548473006635	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
548473006636	isochorismate synthases; Region: isochor_syn; TIGR00543
548473006637	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
548473006638	UbiA prenyltransferase family; Region: UbiA; pfam01040
548473006639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473006640	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
548473006641	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548473006642	Coenzyme A binding pocket [chemical binding]; other site
548473006643	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
548473006644	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
548473006645	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
548473006646	siderophore binding site; other site
548473006647	Predicted membrane protein [Function unknown]; Region: COG2259
548473006648	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
548473006649	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
548473006650	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548473006651	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548473006652	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
548473006653	Walker A/P-loop; other site
548473006654	ATP binding site [chemical binding]; other site
548473006655	Q-loop/lid; other site
548473006656	ABC transporter signature motif; other site
548473006657	Walker B; other site
548473006658	D-loop; other site
548473006659	H-loop/switch region; other site
548473006660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
548473006661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
548473006662	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
548473006663	CAAX protease self-immunity; Region: Abi; pfam02517
548473006664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
548473006665	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
548473006666	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
548473006667	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
548473006668	IDEAL domain; Region: IDEAL; pfam08858
548473006669	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
548473006670	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
548473006671	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
548473006672	active site
548473006673	metal binding site [ion binding]; metal-binding site
548473006674	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
548473006675	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
548473006676	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
548473006677	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
548473006678	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
548473006679	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
548473006680	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
548473006681	yybP-ykoY leader; HMPREF0772_nc10036
548473006682	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
548473006683	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
548473006684	G1 box; other site
548473006685	putative GEF interaction site [polypeptide binding]; other site
548473006686	GTP/Mg2+ binding site [chemical binding]; other site
548473006687	Switch I region; other site
548473006688	G2 box; other site
548473006689	G3 box; other site
548473006690	Switch II region; other site
548473006691	G4 box; other site
548473006692	G5 box; other site
548473006693	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
548473006694	YueH-like protein; Region: YueH; pfam14166
548473006695	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
548473006696	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
548473006697	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
548473006698	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
548473006699	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
548473006700	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
548473006701	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
548473006702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473006703	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473006704	putative substrate translocation pore; other site
548473006705	hypothetical protein; Provisional; Region: PRK13679
548473006706	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
548473006707	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
548473006708	minor groove reading motif; other site
548473006709	helix-hairpin-helix signature motif; other site
548473006710	substrate binding pocket [chemical binding]; other site
548473006711	active site
548473006712	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
548473006713	Putative esterase; Region: Esterase; pfam00756
548473006714	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
548473006715	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
548473006716	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
548473006717	Domain of unknown function DUF20; Region: UPF0118; pfam01594
548473006718	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
548473006719	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
548473006720	NAD binding site [chemical binding]; other site
548473006721	homotetramer interface [polypeptide binding]; other site
548473006722	homodimer interface [polypeptide binding]; other site
548473006723	substrate binding site [chemical binding]; other site
548473006724	active site
548473006725	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
548473006726	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
548473006727	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
548473006728	TrkA-N domain; Region: TrkA_N; pfam02254
548473006729	TrkA-C domain; Region: TrkA_C; pfam02080
548473006730	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
548473006731	MgtE intracellular N domain; Region: MgtE_N; smart00924
548473006732	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
548473006733	Divalent cation transporter; Region: MgtE; pfam01769
548473006734	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
548473006735	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
548473006736	active site
548473006737	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
548473006738	ATP-NAD kinase; Region: NAD_kinase; pfam01513
548473006739	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
548473006740	synthetase active site [active]
548473006741	NTP binding site [chemical binding]; other site
548473006742	metal binding site [ion binding]; metal-binding site
548473006743	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
548473006744	putative active site [active]
548473006745	putative metal binding residues [ion binding]; other site
548473006746	signature motif; other site
548473006747	putative triphosphate binding site [ion binding]; other site
548473006748	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
548473006749	apolar tunnel; other site
548473006750	heme binding site [chemical binding]; other site
548473006751	dimerization interface [polypeptide binding]; other site
548473006752	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
548473006753	Thioredoxin; Region: Thioredoxin_5; pfam13743
548473006754	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
548473006755	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
548473006756	active site
548473006757	Zn binding site [ion binding]; other site
548473006758	Competence protein CoiA-like family; Region: CoiA; cl11541
548473006759	adaptor protein; Provisional; Region: PRK02315
548473006760	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
548473006761	ArsC family; Region: ArsC; pfam03960
548473006762	putative catalytic residues [active]
548473006763	thiol/disulfide switch; other site
548473006764	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
548473006765	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
548473006766	active site
548473006767	HIGH motif; other site
548473006768	dimer interface [polypeptide binding]; other site
548473006769	KMSKS motif; other site
548473006770	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473006771	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
548473006772	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473006773	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473006774	potential frameshift: common BLAST hit: gi|49484437|ref|YP_041661.1| insertion element protein
548473006775	Transposase; Region: HTH_Tnp_1; cl17663
548473006776	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548473006777	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
548473006778	Helix-turn-helix domain; Region: HTH_28; pfam13518
548473006779	HTH-like domain; Region: HTH_21; pfam13276
548473006780	Integrase core domain; Region: rve; pfam00665
548473006781	Integrase core domain; Region: rve_3; cl15866
548473006782	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
548473006783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473006784	dimer interface [polypeptide binding]; other site
548473006785	conserved gate region; other site
548473006786	putative PBP binding loops; other site
548473006787	ABC-ATPase subunit interface; other site
548473006788	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
548473006789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473006790	dimer interface [polypeptide binding]; other site
548473006791	conserved gate region; other site
548473006792	putative PBP binding loops; other site
548473006793	ABC-ATPase subunit interface; other site
548473006794	potential frameshift: common BLAST hit: gi|49483154|ref|YP_040378.1| oligopeptide transport ATP-binding protein
548473006795	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
548473006796	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473006797	Walker B; other site
548473006798	D-loop; other site
548473006799	H-loop/switch region; other site
548473006800	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
548473006801	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473006802	Walker A/P-loop; other site
548473006803	ATP binding site [chemical binding]; other site
548473006804	Q-loop/lid; other site
548473006805	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
548473006806	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473006807	Walker A/P-loop; other site
548473006808	ATP binding site [chemical binding]; other site
548473006809	Q-loop/lid; other site
548473006810	ABC transporter signature motif; other site
548473006811	Walker B; other site
548473006812	D-loop; other site
548473006813	H-loop/switch region; other site
548473006814	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
548473006815	potential frameshift: common BLAST hit: gi|49485767|ref|YP_042988.1| transport system extracellular binding lipoprotein
548473006816	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
548473006817	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
548473006818	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
548473006819	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473006820	Helix-turn-helix domain; Region: HTH_38; pfam13936
548473006821	Integrase core domain; Region: rve; pfam00665
548473006822	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
548473006823	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
548473006824	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
548473006825	peptide binding site [polypeptide binding]; other site
548473006826	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
548473006827	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473006828	Walker A/P-loop; other site
548473006829	ATP binding site [chemical binding]; other site
548473006830	Q-loop/lid; other site
548473006831	ABC transporter signature motif; other site
548473006832	Walker B; other site
548473006833	D-loop; other site
548473006834	H-loop/switch region; other site
548473006835	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
548473006836	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
548473006837	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
548473006838	Walker A/P-loop; other site
548473006839	ATP binding site [chemical binding]; other site
548473006840	Q-loop/lid; other site
548473006841	ABC transporter signature motif; other site
548473006842	Walker B; other site
548473006843	D-loop; other site
548473006844	H-loop/switch region; other site
548473006845	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
548473006846	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
548473006847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473006848	dimer interface [polypeptide binding]; other site
548473006849	conserved gate region; other site
548473006850	putative PBP binding loops; other site
548473006851	ABC-ATPase subunit interface; other site
548473006852	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
548473006853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473006854	dimer interface [polypeptide binding]; other site
548473006855	conserved gate region; other site
548473006856	putative PBP binding loops; other site
548473006857	ABC-ATPase subunit interface; other site
548473006858	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
548473006859	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
548473006860	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
548473006861	dimer interface [polypeptide binding]; other site
548473006862	active site
548473006863	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
548473006864	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
548473006865	dimer interface [polypeptide binding]; other site
548473006866	active site
548473006867	CoA binding pocket [chemical binding]; other site
548473006868	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
548473006869	MAP domain; Region: MAP; pfam03642
548473006870	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
548473006871	substrate binding site [chemical binding]; other site
548473006872	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
548473006873	potential frameshift: common BLAST hit: gi|150393463|ref|YP_001316138.1| 2-isopropylmalate synthase
548473006874	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
548473006875	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
548473006876	active site
548473006877	metal binding site [ion binding]; metal-binding site
548473006878	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
548473006879	catalytic residues [active]
548473006880	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548473006881	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548473006882	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
548473006883	dimerization interface [polypeptide binding]; other site
548473006884	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
548473006885	Clp amino terminal domain; Region: Clp_N; pfam02861
548473006886	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473006887	Walker A motif; other site
548473006888	ATP binding site [chemical binding]; other site
548473006889	Walker B motif; other site
548473006890	arginine finger; other site
548473006891	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
548473006892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473006893	Walker A motif; other site
548473006894	ATP binding site [chemical binding]; other site
548473006895	Walker B motif; other site
548473006896	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
548473006897	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
548473006898	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
548473006899	catalytic triad [active]
548473006900	catalytic triad [active]
548473006901	oxyanion hole [active]
548473006902	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
548473006903	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
548473006904	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473006905	active site
548473006906	motif I; other site
548473006907	motif II; other site
548473006908	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473006909	coenzyme A disulfide reductase; Provisional; Region: PRK13512
548473006910	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548473006911	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473006912	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
548473006913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473006914	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473006915	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
548473006916	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473006917	hypothetical protein; Provisional; Region: PRK13673
548473006918	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
548473006919	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
548473006920	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
548473006921	Part of AAA domain; Region: AAA_19; pfam13245
548473006922	Family description; Region: UvrD_C_2; pfam13538
548473006923	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
548473006924	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
548473006925	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
548473006926	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
548473006927	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
548473006928	Catalytic site [active]
548473006929	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
548473006930	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
548473006931	Catalytic site [active]
548473006932	Uncharacterized conserved protein [Function unknown]; Region: COG0398
548473006933	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
548473006934	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
548473006935	active site
548473006936	dimer interface [polypeptide binding]; other site
548473006937	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
548473006938	dimer interface [polypeptide binding]; other site
548473006939	active site
548473006940	argininosuccinate synthase; Provisional; Region: PRK13820
548473006941	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
548473006942	ANP binding site [chemical binding]; other site
548473006943	Substrate Binding Site II [chemical binding]; other site
548473006944	Substrate Binding Site I [chemical binding]; other site
548473006945	argininosuccinate lyase; Provisional; Region: PRK00855
548473006946	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
548473006947	active sites [active]
548473006948	tetramer interface [polypeptide binding]; other site
548473006949	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
548473006950	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
548473006951	active site
548473006952	catalytic site [active]
548473006953	metal binding site [ion binding]; metal-binding site
548473006954	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
548473006955	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
548473006956	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
548473006957	NAD(P) binding site [chemical binding]; other site
548473006958	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
548473006959	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
548473006960	inhibitor-cofactor binding pocket; inhibition site
548473006961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473006962	catalytic residue [active]
548473006963	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
548473006964	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
548473006965	putative active site [active]
548473006966	putative FMN binding site [chemical binding]; other site
548473006967	putative substrate binding site [chemical binding]; other site
548473006968	putative catalytic residue [active]
548473006969	general stress protein 13; Validated; Region: PRK08059
548473006970	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
548473006971	RNA binding site [nucleotide binding]; other site
548473006972	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473006973	Helix-turn-helix domain; Region: HTH_38; pfam13936
548473006974	Integrase core domain; Region: rve; pfam00665
548473006975	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
548473006976	active site
548473006977	Kinase associated protein B; Region: KapB; pfam08810
548473006978	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
548473006979	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
548473006980	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
548473006981	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
548473006982	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
548473006983	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
548473006984	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
548473006985	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
548473006986	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
548473006987	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
548473006988	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548473006989	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
548473006990	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
548473006991	CoenzymeA binding site [chemical binding]; other site
548473006992	subunit interaction site [polypeptide binding]; other site
548473006993	PHB binding site; other site
548473006994	Predicted permease [General function prediction only]; Region: COG2056
548473006995	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
548473006996	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
548473006997	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
548473006998	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
548473006999	interface (dimer of trimers) [polypeptide binding]; other site
548473007000	Substrate-binding/catalytic site; other site
548473007001	Zn-binding sites [ion binding]; other site
548473007002	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
548473007003	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473007004	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
548473007005	hypothetical protein; Provisional; Region: PRK13669
548473007006	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
548473007007	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473007008	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
548473007009	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
548473007010	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
548473007011	DltD N-terminal region; Region: DltD_N; pfam04915
548473007012	DltD central region; Region: DltD_M; pfam04918
548473007013	DltD C-terminal region; Region: DltD_C; pfam04914
548473007014	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
548473007015	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
548473007016	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
548473007017	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
548473007018	acyl-activating enzyme (AAE) consensus motif; other site
548473007019	AMP binding site [chemical binding]; other site
548473007020	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
548473007021	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
548473007022	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
548473007023	dimerization interface [polypeptide binding]; other site
548473007024	ligand binding site [chemical binding]; other site
548473007025	NADP binding site [chemical binding]; other site
548473007026	catalytic site [active]
548473007027	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
548473007028	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473007029	active site
548473007030	motif I; other site
548473007031	motif II; other site
548473007032	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473007033	Uncharacterized conserved protein [Function unknown]; Region: COG2445
548473007034	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
548473007035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
548473007036	lipoyl synthase; Provisional; Region: PRK05481
548473007037	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
548473007038	FeS/SAM binding site; other site
548473007039	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
548473007040	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
548473007041	active site
548473007042	metal binding site [ion binding]; metal-binding site
548473007043	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
548473007044	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
548473007045	Uncharacterized conserved protein [Function unknown]; Region: COG1801
548473007046	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
548473007047	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
548473007048	FMN binding site [chemical binding]; other site
548473007049	substrate binding site [chemical binding]; other site
548473007050	putative catalytic residue [active]
548473007051	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
548473007052	Domain of unknown function DUF21; Region: DUF21; pfam01595
548473007053	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
548473007054	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
548473007055	FeS assembly protein SufB; Region: sufB; TIGR01980
548473007056	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
548473007057	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
548473007058	trimerization site [polypeptide binding]; other site
548473007059	active site
548473007060	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
548473007061	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
548473007062	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
548473007063	catalytic residue [active]
548473007064	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
548473007065	FeS assembly protein SufD; Region: sufD; TIGR01981
548473007066	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
548473007067	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
548473007068	Walker A/P-loop; other site
548473007069	ATP binding site [chemical binding]; other site
548473007070	Q-loop/lid; other site
548473007071	ABC transporter signature motif; other site
548473007072	Walker B; other site
548473007073	D-loop; other site
548473007074	H-loop/switch region; other site
548473007075	Predicted membrane protein [Function unknown]; Region: COG2035
548473007076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
548473007077	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
548473007078	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
548473007079	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
548473007080	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
548473007081	Protein of unknown function (DUF1474); Region: DUF1474; pfam07342
548473007082	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473007083	non-specific DNA binding site [nucleotide binding]; other site
548473007084	salt bridge; other site
548473007085	sequence-specific DNA binding site [nucleotide binding]; other site
548473007086	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
548473007087	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473007088	non-specific DNA binding site [nucleotide binding]; other site
548473007089	salt bridge; other site
548473007090	sequence-specific DNA binding site [nucleotide binding]; other site
548473007091	SAP domain; Region: SAP; pfam02037
548473007092	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
548473007093	Int/Topo IB signature motif; other site
548473007094	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
548473007095	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
548473007096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473007097	dimer interface [polypeptide binding]; other site
548473007098	conserved gate region; other site
548473007099	ABC-ATPase subunit interface; other site
548473007100	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
548473007101	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
548473007102	Walker A/P-loop; other site
548473007103	ATP binding site [chemical binding]; other site
548473007104	Q-loop/lid; other site
548473007105	ABC transporter signature motif; other site
548473007106	Walker B; other site
548473007107	D-loop; other site
548473007108	H-loop/switch region; other site
548473007109	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
548473007110	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
548473007111	catalytic residues [active]
548473007112	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
548473007113	putative active site [active]
548473007114	putative metal binding site [ion binding]; other site
548473007115	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
548473007116	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
548473007117	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
548473007118	lipoyl attachment site [posttranslational modification]; other site
548473007119	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
548473007120	ArsC family; Region: ArsC; pfam03960
548473007121	putative ArsC-like catalytic residues; other site
548473007122	putative TRX-like catalytic residues [active]
548473007123	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
548473007124	catalytic residues [active]
548473007125	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
548473007126	putative FMN binding site [chemical binding]; other site
548473007127	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
548473007128	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
548473007129	active site
548473007130	catalytic residue [active]
548473007131	dimer interface [polypeptide binding]; other site
548473007132	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
548473007133	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548473007134	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
548473007135	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548473007136	Lysine efflux permease [General function prediction only]; Region: COG1279
548473007137	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
548473007138	catalytic core [active]
548473007139	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
548473007140	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
548473007141	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
548473007142	DNA-binding site [nucleotide binding]; DNA binding site
548473007143	RNA-binding motif; other site
548473007144	Staphylococcal nuclease homologues; Region: SNc; smart00318
548473007145	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
548473007146	Catalytic site; other site
548473007147	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
548473007148	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473007149	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
548473007150	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473007151	Coenzyme A binding pocket [chemical binding]; other site
548473007152	Integral membrane protein DUF95; Region: DUF95; pfam01944
548473007153	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
548473007154	SmpB-tmRNA interface; other site
548473007155	ribonuclease R; Region: RNase_R; TIGR02063
548473007156	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
548473007157	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
548473007158	RNB domain; Region: RNB; pfam00773
548473007159	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
548473007160	RNA binding site [nucleotide binding]; other site
548473007161	Esterase/lipase [General function prediction only]; Region: COG1647
548473007162	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
548473007163	enolase; Provisional; Region: eno; PRK00077
548473007164	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
548473007165	dimer interface [polypeptide binding]; other site
548473007166	metal binding site [ion binding]; metal-binding site
548473007167	substrate binding pocket [chemical binding]; other site
548473007168	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
548473007169	phosphoglyceromutase; Provisional; Region: PRK05434
548473007170	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
548473007171	triosephosphate isomerase; Provisional; Region: PRK14565
548473007172	substrate binding site [chemical binding]; other site
548473007173	dimer interface [polypeptide binding]; other site
548473007174	catalytic triad [active]
548473007175	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
548473007176	Phosphoglycerate kinase; Region: PGK; pfam00162
548473007177	substrate binding site [chemical binding]; other site
548473007178	hinge regions; other site
548473007179	ADP binding site [chemical binding]; other site
548473007180	catalytic site [active]
548473007181	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
548473007182	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
548473007183	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
548473007184	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
548473007185	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
548473007186	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
548473007187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548473007188	NAD(P) binding site [chemical binding]; other site
548473007189	active site
548473007190	malate dehydrogenase; Provisional; Region: PRK13529
548473007191	Malic enzyme, N-terminal domain; Region: malic; pfam00390
548473007192	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
548473007193	NAD(P) binding site [chemical binding]; other site
548473007194	Clp protease; Region: CLP_protease; pfam00574
548473007195	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
548473007196	oligomer interface [polypeptide binding]; other site
548473007197	active site residues [active]
548473007198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
548473007199	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
548473007200	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
548473007201	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
548473007202	phosphate binding site [ion binding]; other site
548473007203	dimer interface [polypeptide binding]; other site
548473007204	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
548473007205	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
548473007206	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
548473007207	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473007208	TPR repeat; Region: TPR_11; pfam13414
548473007209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
548473007210	binding surface
548473007211	TPR motif; other site
548473007212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
548473007213	TPR motif; other site
548473007214	binding surface
548473007215	putative acyl transferase; Provisional; Region: PRK10191
548473007216	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
548473007217	trimer interface [polypeptide binding]; other site
548473007218	active site
548473007219	substrate binding site [chemical binding]; other site
548473007220	CoA binding site [chemical binding]; other site
548473007221	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
548473007222	HPr kinase/phosphorylase; Provisional; Region: PRK05428
548473007223	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
548473007224	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
548473007225	Hpr binding site; other site
548473007226	active site
548473007227	homohexamer subunit interaction site [polypeptide binding]; other site
548473007228	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
548473007229	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
548473007230	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
548473007231	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
548473007232	excinuclease ABC subunit B; Provisional; Region: PRK05298
548473007233	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473007234	ATP binding site [chemical binding]; other site
548473007235	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548473007236	nucleotide binding region [chemical binding]; other site
548473007237	ATP-binding site [chemical binding]; other site
548473007238	Ultra-violet resistance protein B; Region: UvrB; pfam12344
548473007239	UvrB/uvrC motif; Region: UVR; pfam02151
548473007240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
548473007241	HD domain; Region: HD_3; cl17350
548473007242	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
548473007243	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
548473007244	Surface antigen [General function prediction only]; Region: COG3942
548473007245	CHAP domain; Region: CHAP; pfam05257
548473007246	peptide chain release factor 2; Provisional; Region: PRK06746
548473007247	This domain is found in peptide chain release factors; Region: PCRF; smart00937
548473007248	RF-1 domain; Region: RF-1; pfam00472
548473007249	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
548473007250	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
548473007251	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
548473007252	nucleotide binding region [chemical binding]; other site
548473007253	ATP-binding site [chemical binding]; other site
548473007254	SEC-C motif; Region: SEC-C; pfam02810
548473007255	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
548473007256	30S subunit binding site; other site
548473007257	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
548473007258	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
548473007259	active site
548473007260	DEAD-like helicases superfamily; Region: DEXDc; smart00487
548473007261	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473007262	ATP binding site [chemical binding]; other site
548473007263	putative Mg++ binding site [ion binding]; other site
548473007264	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548473007265	nucleotide binding region [chemical binding]; other site
548473007266	ATP-binding site [chemical binding]; other site
548473007267	EDD domain protein, DegV family; Region: DegV; TIGR00762
548473007268	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
548473007269	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
548473007270	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
548473007271	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
548473007272	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
548473007273	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
548473007274	Mg++ binding site [ion binding]; other site
548473007275	putative catalytic motif [active]
548473007276	substrate binding site [chemical binding]; other site
548473007277	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
548473007278	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
548473007279	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
548473007280	metal binding site [ion binding]; metal-binding site
548473007281	active site
548473007282	I-site; other site
548473007283	Uncharacterized conserved protein [Function unknown]; Region: COG2966
548473007284	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
548473007285	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
548473007286	Uncharacterized conserved protein [Function unknown]; Region: COG3610
548473007287	peptidase T; Region: peptidase-T; TIGR01882
548473007288	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
548473007289	metal binding site [ion binding]; metal-binding site
548473007290	dimer interface [polypeptide binding]; other site
548473007291	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
548473007292	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
548473007293	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
548473007294	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
548473007295	FAD binding domain; Region: FAD_binding_4; pfam01565
548473007296	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
548473007297	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
548473007298	CHY zinc finger; Region: zf-CHY; pfam05495
548473007299	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
548473007300	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
548473007301	putative ligand binding residues [chemical binding]; other site
548473007302	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
548473007303	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
548473007304	Walker A/P-loop; other site
548473007305	ATP binding site [chemical binding]; other site
548473007306	Q-loop/lid; other site
548473007307	ABC transporter signature motif; other site
548473007308	Walker B; other site
548473007309	D-loop; other site
548473007310	H-loop/switch region; other site
548473007311	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473007312	ABC-ATPase subunit  interface; other site
548473007313	dimer interface [polypeptide binding]; other site
548473007314	putative PBP binding regions; other site
548473007315	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473007316	ABC-ATPase subunit  interface; other site
548473007317	dimer interface [polypeptide binding]; other site
548473007318	putative PBP binding regions; other site
548473007319	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
548473007320	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
548473007321	dimer interface [polypeptide binding]; other site
548473007322	putative radical transfer pathway; other site
548473007323	diiron center [ion binding]; other site
548473007324	tyrosyl radical; other site
548473007325	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
548473007326	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
548473007327	Class I ribonucleotide reductase; Region: RNR_I; cd01679
548473007328	active site
548473007329	dimer interface [polypeptide binding]; other site
548473007330	catalytic residues [active]
548473007331	effector binding site; other site
548473007332	R2 peptide binding site; other site
548473007333	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
548473007334	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
548473007335	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
548473007336	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
548473007337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473007338	putative substrate translocation pore; other site
548473007339	POT family; Region: PTR2; cl17359
548473007340	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
548473007341	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
548473007342	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
548473007343	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
548473007344	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548473007345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473007346	homodimer interface [polypeptide binding]; other site
548473007347	catalytic residue [active]
548473007348	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
548473007349	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
548473007350	dimer interface [polypeptide binding]; other site
548473007351	conserved gate region; other site
548473007352	ABC-ATPase subunit interface; other site
548473007353	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
548473007354	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
548473007355	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
548473007356	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
548473007357	Walker A/P-loop; other site
548473007358	ATP binding site [chemical binding]; other site
548473007359	Q-loop/lid; other site
548473007360	ABC transporter signature motif; other site
548473007361	Walker B; other site
548473007362	D-loop; other site
548473007363	H-loop/switch region; other site
548473007364	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
548473007365	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
548473007366	ATP binding site [chemical binding]; other site
548473007367	putative Mg++ binding site [ion binding]; other site
548473007368	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
548473007369	nucleotide binding region [chemical binding]; other site
548473007370	ATP-binding site [chemical binding]; other site
548473007371	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
548473007372	HRDC domain; Region: HRDC; pfam00570
548473007373	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
548473007374	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548473007375	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548473007376	ABC transporter; Region: ABC_tran_2; pfam12848
548473007377	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
548473007378	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
548473007379	Sulfatase; Region: Sulfatase; pfam00884
548473007380	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
548473007381	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
548473007382	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
548473007383	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
548473007384	substrate-cofactor binding pocket; other site
548473007385	Aminotransferase class IV; Region: Aminotran_4; pfam01063
548473007386	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473007387	catalytic residue [active]
548473007388	aminodeoxychorismate synthase; Provisional; Region: PRK07508
548473007389	chorismate binding enzyme; Region: Chorismate_bind; cl10555
548473007390	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
548473007391	Glutamine amidotransferase class-I; Region: GATase; pfam00117
548473007392	glutamine binding [chemical binding]; other site
548473007393	catalytic triad [active]
548473007394	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
548473007395	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
548473007396	Ligand Binding Site [chemical binding]; other site
548473007397	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
548473007398	active site
548473007399	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
548473007400	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
548473007401	Electron transfer DM13; Region: DM13; pfam10517
548473007402	DoxX; Region: DoxX; pfam07681
548473007403	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548473007404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473007405	active site
548473007406	phosphorylation site [posttranslational modification]
548473007407	intermolecular recognition site; other site
548473007408	dimerization interface [polypeptide binding]; other site
548473007409	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548473007410	DNA binding site [nucleotide binding]
548473007411	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
548473007412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
548473007413	dimer interface [polypeptide binding]; other site
548473007414	phosphorylation site [posttranslational modification]
548473007415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473007416	ATP binding site [chemical binding]; other site
548473007417	Mg2+ binding site [ion binding]; other site
548473007418	G-X-G motif; other site
548473007419	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
548473007420	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
548473007421	Ligand binding site; other site
548473007422	Putative Catalytic site; other site
548473007423	DXD motif; other site
548473007424	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
548473007425	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
548473007426	active site
548473007427	catalytic tetrad [active]
548473007428	Domain of unknown function DUF21; Region: DUF21; pfam01595
548473007429	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
548473007430	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
548473007431	Transporter associated domain; Region: CorC_HlyC; pfam03471
548473007432	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
548473007433	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
548473007434	active site
548473007435	dimer interface [polypeptide binding]; other site
548473007436	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
548473007437	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
548473007438	active site
548473007439	phosphorylation site [posttranslational modification]
548473007440	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
548473007441	active site
548473007442	P-loop; other site
548473007443	phosphorylation site [posttranslational modification]
548473007444	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
548473007445	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
548473007446	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
548473007447	putative substrate binding site [chemical binding]; other site
548473007448	putative ATP binding site [chemical binding]; other site
548473007449	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
548473007450	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
548473007451	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
548473007452	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
548473007453	putative deacylase active site [active]
548473007454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473007455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
548473007456	putative substrate translocation pore; other site
548473007457	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
548473007458	trimer interface [polypeptide binding]; other site
548473007459	putative Zn binding site [ion binding]; other site
548473007460	Predicted membrane protein [Function unknown]; Region: COG4330
548473007461	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
548473007462	DNA photolyase; Region: DNA_photolyase; pfam00875
548473007463	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
548473007464	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
548473007465	transmembrane helices; other site
548473007466	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
548473007467	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
548473007468	active site
548473007469	catalytic tetrad [active]
548473007470	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
548473007471	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
548473007472	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
548473007473	Transcriptional regulators [Transcription]; Region: MarR; COG1846
548473007474	MarR family; Region: MarR; pfam01047
548473007475	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
548473007476	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548473007477	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
548473007478	Walker A/P-loop; other site
548473007479	ATP binding site [chemical binding]; other site
548473007480	Q-loop/lid; other site
548473007481	ABC transporter signature motif; other site
548473007482	Walker B; other site
548473007483	D-loop; other site
548473007484	H-loop/switch region; other site
548473007485	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
548473007486	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548473007487	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
548473007488	Walker A/P-loop; other site
548473007489	ATP binding site [chemical binding]; other site
548473007490	Q-loop/lid; other site
548473007491	ABC transporter signature motif; other site
548473007492	Walker B; other site
548473007493	D-loop; other site
548473007494	H-loop/switch region; other site
548473007495	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
548473007496	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
548473007497	hypothetical protein; Validated; Region: PRK00124
548473007498	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
548473007499	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
548473007500	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
548473007501	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
548473007502	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473007503	Coenzyme A binding pocket [chemical binding]; other site
548473007504	Serine incorporator (Serinc); Region: Serinc; pfam03348
548473007505	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
548473007506	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473007507	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
548473007508	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
548473007509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
548473007510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473007511	sugar efflux transporter; Region: 2A0120; TIGR00899
548473007512	putative substrate translocation pore; other site
548473007513	Transcriptional regulator [Transcription]; Region: LysR; COG0583
548473007514	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
548473007515	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
548473007516	dimerization interface [polypeptide binding]; other site
548473007517	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
548473007518	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
548473007519	hypothetical protein; Provisional; Region: PRK12378
548473007520	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
548473007521	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
548473007522	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
548473007523	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
548473007524	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
548473007525	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
548473007526	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
548473007527	Surface antigen [General function prediction only]; Region: COG3942
548473007528	CHAP domain; Region: CHAP; pfam05257
548473007529	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
548473007530	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
548473007531	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
548473007532	FtsX-like permease family; Region: FtsX; pfam02687
548473007533	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
548473007534	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548473007535	Walker A/P-loop; other site
548473007536	ATP binding site [chemical binding]; other site
548473007537	Q-loop/lid; other site
548473007538	ABC transporter signature motif; other site
548473007539	Walker B; other site
548473007540	D-loop; other site
548473007541	H-loop/switch region; other site
548473007542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
548473007543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
548473007544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
548473007545	ATP binding site [chemical binding]; other site
548473007546	Mg2+ binding site [ion binding]; other site
548473007547	G-X-G motif; other site
548473007548	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
548473007549	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
548473007550	active site
548473007551	phosphorylation site [posttranslational modification]
548473007552	intermolecular recognition site; other site
548473007553	dimerization interface [polypeptide binding]; other site
548473007554	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
548473007555	DNA binding site [nucleotide binding]
548473007556	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
548473007557	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548473007558	NAD(P) binding site [chemical binding]; other site
548473007559	active site
548473007560	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
548473007561	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473007562	Coenzyme A binding pocket [chemical binding]; other site
548473007563	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
548473007564	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
548473007565	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
548473007566	substrate binding pocket [chemical binding]; other site
548473007567	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
548473007568	Uncharacterized membrane protein [Function unknown]; Region: COG3949
548473007569	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
548473007570	Na binding site [ion binding]; other site
548473007571	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
548473007572	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
548473007573	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
548473007574	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
548473007575	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
548473007576	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
548473007577	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473007578	ABC-ATPase subunit  interface; other site
548473007579	dimer interface [polypeptide binding]; other site
548473007580	putative PBP binding regions; other site
548473007581	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
548473007582	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473007583	ABC-ATPase subunit  interface; other site
548473007584	dimer interface [polypeptide binding]; other site
548473007585	putative PBP binding regions; other site
548473007586	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
548473007587	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
548473007588	Walker A/P-loop; other site
548473007589	ATP binding site [chemical binding]; other site
548473007590	Q-loop/lid; other site
548473007591	ABC transporter signature motif; other site
548473007592	Walker B; other site
548473007593	D-loop; other site
548473007594	H-loop/switch region; other site
548473007595	Uncharacterized conserved protein [Function unknown]; Region: COG1284
548473007596	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
548473007597	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
548473007598	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
548473007599	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
548473007600	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
548473007601	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
548473007602	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
548473007603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
548473007604	Walker A/P-loop; other site
548473007605	ATP binding site [chemical binding]; other site
548473007606	Q-loop/lid; other site
548473007607	ABC transporter signature motif; other site
548473007608	Walker B; other site
548473007609	D-loop; other site
548473007610	H-loop/switch region; other site
548473007611	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
548473007612	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
548473007613	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
548473007614	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548473007615	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
548473007616	active site
548473007617	nucleotide binding site [chemical binding]; other site
548473007618	HIGH motif; other site
548473007619	KMSKS motif; other site
548473007620	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
548473007621	active site
548473007622	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
548473007623	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
548473007624	ABC-2 type transporter; Region: ABC2_membrane; cl17235
548473007625	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
548473007626	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
548473007627	Walker A/P-loop; other site
548473007628	ATP binding site [chemical binding]; other site
548473007629	Q-loop/lid; other site
548473007630	ABC transporter signature motif; other site
548473007631	Walker B; other site
548473007632	D-loop; other site
548473007633	H-loop/switch region; other site
548473007634	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
548473007635	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
548473007636	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
548473007637	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
548473007638	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
548473007639	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
548473007640	FeoA domain; Region: FeoA; pfam04023
548473007641	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
548473007642	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
548473007643	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
548473007644	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473007645	ABC-ATPase subunit  interface; other site
548473007646	dimer interface [polypeptide binding]; other site
548473007647	putative PBP binding regions; other site
548473007648	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
548473007649	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
548473007650	metal binding site [ion binding]; metal-binding site
548473007651	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
548473007652	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473007653	motif II; other site
548473007654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473007655	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
548473007656	putative substrate translocation pore; other site
548473007657	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
548473007658	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
548473007659	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
548473007660	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
548473007661	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
548473007662	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
548473007663	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
548473007664	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
548473007665	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
548473007666	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
548473007667	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
548473007668	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
548473007669	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
548473007670	active site
548473007671	DNA binding site [nucleotide binding]
548473007672	Int/Topo IB signature motif; other site
548473007673	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
548473007674	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
548473007675	Protein of unknown function, DUF606; Region: DUF606; pfam04657
548473007676	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
548473007677	Transcriptional regulators [Transcription]; Region: MarR; COG1846
548473007678	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
548473007679	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
548473007680	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
548473007681	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
548473007682	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
548473007683	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473007684	motif II; other site
548473007685	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
548473007686	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
548473007687	ABC-ATPase subunit  interface; other site
548473007688	dimer interface [polypeptide binding]; other site
548473007689	putative PBP binding regions; other site
548473007690	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
548473007691	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
548473007692	putative binding site residues; other site
548473007693	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
548473007694	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
548473007695	minor groove reading motif; other site
548473007696	helix-hairpin-helix signature motif; other site
548473007697	substrate binding pocket [chemical binding]; other site
548473007698	active site
548473007699	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
548473007700	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
548473007701	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
548473007702	active site
548473007703	HIGH motif; other site
548473007704	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
548473007705	KMSK motif region; other site
548473007706	tRNA binding surface [nucleotide binding]; other site
548473007707	DALR anticodon binding domain; Region: DALR_1; smart00836
548473007708	anticodon binding site; other site
548473007709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
548473007710	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
548473007711	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
548473007712	NAD binding site [chemical binding]; other site
548473007713	substrate binding site [chemical binding]; other site
548473007714	catalytic Zn binding site [ion binding]; other site
548473007715	tetramer interface [polypeptide binding]; other site
548473007716	structural Zn binding site [ion binding]; other site
548473007717	YwhD family; Region: YwhD; pfam08741
548473007718	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
548473007719	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
548473007720	Zn2+ binding site [ion binding]; other site
548473007721	Mg2+ binding site [ion binding]; other site
548473007722	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
548473007723	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
548473007724	Coenzyme A binding pocket [chemical binding]; other site
548473007725	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
548473007726	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
548473007727	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
548473007728	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
548473007729	active site
548473007730	catalytic tetrad [active]
548473007731	Protein of unknown function (DUF443); Region: DUF443; pfam04276
548473007732	Protein of unknown function (DUF443); Region: DUF443; pfam04276
548473007733	Protein of unknown function (DUF443); Region: DUF443; pfam04276
548473007734	LXG domain of WXG superfamily; Region: LXG; pfam04740
548473007735	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
548473007736	Helix-turn-helix domain; Region: HTH_38; pfam13936
548473007737	Integrase core domain; Region: rve; pfam00665
548473007738	Predicted transcriptional regulator [Transcription]; Region: COG1959
548473007739	Transcriptional regulator; Region: Rrf2; pfam02082
548473007740	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
548473007741	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
548473007742	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
548473007743	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
548473007744	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
548473007745	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
548473007746	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
548473007747	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
548473007748	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
548473007749	diphosphomevalonate decarboxylase; Region: PLN02407
548473007750	mevalonate kinase; Region: mevalon_kin; TIGR00549
548473007751	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
548473007752	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
548473007753	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
548473007754	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
548473007755	putative heme peroxidase; Provisional; Region: PRK12276
548473007756	Uncharacterized conserved protein [Function unknown]; Region: COG2966
548473007757	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
548473007758	Uncharacterized conserved protein [Function unknown]; Region: COG3610
548473007759	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
548473007760	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
548473007761	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
548473007762	ligand binding site [chemical binding]; other site
548473007763	active site
548473007764	UGI interface [polypeptide binding]; other site
548473007765	catalytic site [active]
548473007766	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
548473007767	dimer interface [polypeptide binding]; other site
548473007768	substrate binding site [chemical binding]; other site
548473007769	ATP binding site [chemical binding]; other site
548473007770	hypothetical protein; Provisional; Region: PRK08582
548473007771	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
548473007772	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
548473007773	dimer interface [polypeptide binding]; other site
548473007774	active site
548473007775	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
548473007776	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
548473007777	acyl-activating enzyme (AAE) consensus motif; other site
548473007778	AMP binding site [chemical binding]; other site
548473007779	active site
548473007780	CoA binding site [chemical binding]; other site
548473007781	proline/glycine betaine transporter; Provisional; Region: PRK10642
548473007782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
548473007783	putative substrate translocation pore; other site
548473007784	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
548473007785	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473007786	motif II; other site
548473007787	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
548473007788	tetramer interface [polypeptide binding]; other site
548473007789	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
548473007790	active site
548473007791	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
548473007792	active site
548473007793	dimer interface [polypeptide binding]; other site
548473007794	magnesium binding site [ion binding]; other site
548473007795	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
548473007796	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
548473007797	active site
548473007798	trimer interface [polypeptide binding]; other site
548473007799	allosteric site; other site
548473007800	active site lid [active]
548473007801	hexamer (dimer of trimers) interface [polypeptide binding]; other site
548473007802	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
548473007803	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
548473007804	putative GTP cyclohydrolase; Provisional; Region: PRK13674
548473007805	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
548473007806	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
548473007807	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548473007808	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
548473007809	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
548473007810	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
548473007811	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473007812	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
548473007813	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
548473007814	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
548473007815	Cna protein B-type domain; Region: Cna_B; pfam05738
548473007816	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
548473007817	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473007818	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
548473007819	Cna protein B-type domain; Region: Cna_B; pfam05738
548473007820	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
548473007821	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
548473007822	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
548473007823	Cna protein B-type domain; Region: Cna_B; pfam05738
548473007824	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
548473007825	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
548473007826	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
548473007827	Cna protein B-type domain; Region: Cna_B; pfam05738
548473007828	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
548473007829	Predicted flavoprotein [General function prediction only]; Region: COG0431
548473007830	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
548473007831	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473007832	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
548473007833	active site
548473007834	motif I; other site
548473007835	motif II; other site
548473007836	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473007837	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
548473007838	nucleoside/Zn binding site; other site
548473007839	dimer interface [polypeptide binding]; other site
548473007840	catalytic motif [active]
548473007841	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
548473007842	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
548473007843	Substrate-binding site [chemical binding]; other site
548473007844	Substrate specificity [chemical binding]; other site
548473007845	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
548473007846	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
548473007847	Substrate-binding site [chemical binding]; other site
548473007848	Substrate specificity [chemical binding]; other site
548473007849	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
548473007850	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
548473007851	motif II; other site
548473007852	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
548473007853	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
548473007854	homodimer interface [polypeptide binding]; other site
548473007855	substrate-cofactor binding pocket; other site
548473007856	catalytic residue [active]
548473007857	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
548473007858	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
548473007859	NAD(P) binding site [chemical binding]; other site
548473007860	active site
548473007861	ribulokinase; Provisional; Region: PRK04123
548473007862	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
548473007863	N- and C-terminal domain interface [polypeptide binding]; other site
548473007864	active site
548473007865	MgATP binding site [chemical binding]; other site
548473007866	catalytic site [active]
548473007867	metal binding site [ion binding]; metal-binding site
548473007868	carbohydrate binding site [chemical binding]; other site
548473007869	homodimer interface [polypeptide binding]; other site
548473007870	chaperone protein HchA; Provisional; Region: PRK04155
548473007871	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
548473007872	conserved cys residue [active]
548473007873	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
548473007874	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
548473007875	substrate-cofactor binding pocket; other site
548473007876	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473007877	catalytic residue [active]
548473007878	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
548473007879	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
548473007880	metal binding site [ion binding]; metal-binding site
548473007881	dimer interface [polypeptide binding]; other site
548473007882	elongation factor Tu; Reviewed; Region: PRK00049
548473007883	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
548473007884	G1 box; other site
548473007885	GEF interaction site [polypeptide binding]; other site
548473007886	GTP/Mg2+ binding site [chemical binding]; other site
548473007887	Switch I region; other site
548473007888	G2 box; other site
548473007889	G3 box; other site
548473007890	Switch II region; other site
548473007891	G4 box; other site
548473007892	G5 box; other site
548473007893	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
548473007894	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
548473007895	Antibiotic Binding Site [chemical binding]; other site
548473007896	elongation factor G; Reviewed; Region: PRK00007
548473007897	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
548473007898	G1 box; other site
548473007899	putative GEF interaction site [polypeptide binding]; other site
548473007900	GTP/Mg2+ binding site [chemical binding]; other site
548473007901	Switch I region; other site
548473007902	G2 box; other site
548473007903	G3 box; other site
548473007904	Switch II region; other site
548473007905	G4 box; other site
548473007906	G5 box; other site
548473007907	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
548473007908	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
548473007909	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
548473007910	30S ribosomal protein S7; Validated; Region: PRK05302
548473007911	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
548473007912	S17 interaction site [polypeptide binding]; other site
548473007913	S8 interaction site; other site
548473007914	16S rRNA interaction site [nucleotide binding]; other site
548473007915	streptomycin interaction site [chemical binding]; other site
548473007916	23S rRNA interaction site [nucleotide binding]; other site
548473007917	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
548473007918	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
548473007919	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
548473007920	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
548473007921	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
548473007922	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
548473007923	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
548473007924	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
548473007925	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
548473007926	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
548473007927	G-loop; other site
548473007928	DNA binding site [nucleotide binding]
548473007929	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
548473007930	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
548473007931	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
548473007932	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
548473007933	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
548473007934	RPB10 interaction site [polypeptide binding]; other site
548473007935	RPB1 interaction site [polypeptide binding]; other site
548473007936	RPB11 interaction site [polypeptide binding]; other site
548473007937	RPB3 interaction site [polypeptide binding]; other site
548473007938	RPB12 interaction site [polypeptide binding]; other site
548473007939	Methyltransferase domain; Region: Methyltransf_31; pfam13847
548473007940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
548473007941	S-adenosylmethionine binding site [chemical binding]; other site
548473007942	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
548473007943	peripheral dimer interface [polypeptide binding]; other site
548473007944	core dimer interface [polypeptide binding]; other site
548473007945	L10 interface [polypeptide binding]; other site
548473007946	L11 interface [polypeptide binding]; other site
548473007947	putative EF-Tu interaction site [polypeptide binding]; other site
548473007948	putative EF-G interaction site [polypeptide binding]; other site
548473007949	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
548473007950	23S rRNA interface [nucleotide binding]; other site
548473007951	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
548473007952	Ribosomal protein L10 leader; HMPREF0772_nc10040
548473007953	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
548473007954	mRNA/rRNA interface [nucleotide binding]; other site
548473007955	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
548473007956	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
548473007957	23S rRNA interface [nucleotide binding]; other site
548473007958	L7/L12 interface [polypeptide binding]; other site
548473007959	putative thiostrepton binding site; other site
548473007960	L25 interface [polypeptide binding]; other site
548473007961	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
548473007962	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
548473007963	putative homodimer interface [polypeptide binding]; other site
548473007964	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
548473007965	heterodimer interface [polypeptide binding]; other site
548473007966	homodimer interface [polypeptide binding]; other site
548473007967	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
548473007968	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
548473007969	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
548473007970	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
548473007971	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
548473007972	DNA binding residues [nucleotide binding]
548473007973	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
548473007974	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
548473007975	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
548473007976	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
548473007977	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
548473007978	active site
548473007979	dimerization interface [polypeptide binding]; other site
548473007980	metal binding site [ion binding]; metal-binding site
548473007981	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
548473007982	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
548473007983	active site
548473007984	HIGH motif; other site
548473007985	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
548473007986	KMSKS motif; other site
548473007987	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
548473007988	tRNA binding surface [nucleotide binding]; other site
548473007989	anticodon binding site; other site
548473007990	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
548473007991	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
548473007992	trimer interface [polypeptide binding]; other site
548473007993	active site
548473007994	substrate binding site [chemical binding]; other site
548473007995	CoA binding site [chemical binding]; other site
548473007996	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
548473007997	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
548473007998	active site
548473007999	HIGH motif; other site
548473008000	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
548473008001	active site
548473008002	KMSKS motif; other site
548473008003	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
548473008004	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
548473008005	putative active site [active]
548473008006	DNA repair protein RadA; Provisional; Region: PRK11823
548473008007	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
548473008008	Walker A motif/ATP binding site; other site
548473008009	ATP binding site [chemical binding]; other site
548473008010	Walker B motif; other site
548473008011	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
548473008012	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
548473008013	Clp amino terminal domain; Region: Clp_N; pfam02861
548473008014	Clp amino terminal domain; Region: Clp_N; pfam02861
548473008015	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473008016	Walker A motif; other site
548473008017	ATP binding site [chemical binding]; other site
548473008018	Walker B motif; other site
548473008019	arginine finger; other site
548473008020	UvrB/uvrC motif; Region: UVR; pfam02151
548473008021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
548473008022	Walker A motif; other site
548473008023	ATP binding site [chemical binding]; other site
548473008024	Walker B motif; other site
548473008025	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
548473008026	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
548473008027	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
548473008028	ADP binding site [chemical binding]; other site
548473008029	phosphagen binding site; other site
548473008030	substrate specificity loop; other site
548473008031	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
548473008032	UvrB/uvrC motif; Region: UVR; pfam02151
548473008033	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
548473008034	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
548473008035	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
548473008036	Nucleoside recognition; Region: Gate; pfam07670
548473008037	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
548473008038	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
548473008039	predicted active site [active]
548473008040	catalytic triad [active]
548473008041	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
548473008042	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
548473008043	active site
548473008044	multimer interface [polypeptide binding]; other site
548473008045	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
548473008046	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
548473008047	DNA-binding site [nucleotide binding]; DNA binding site
548473008048	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
548473008049	pyridoxal 5'-phosphate binding site [chemical binding]; other site
548473008050	homodimer interface [polypeptide binding]; other site
548473008051	catalytic residue [active]
548473008052	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
548473008053	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
548473008054	Integrase core domain; Region: rve; pfam00665
548473008055	Replication protein; Region: Rep_1; pfam01446
548473008056	Replication protein; Region: Rep_1; cl02412
548473008057	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
548473008058	putative DNA binding site [nucleotide binding]; other site
548473008059	putative Zn2+ binding site [ion binding]; other site
548473008060	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
548473008061	Cadmium resistance transporter; Region: Cad; pfam03596
548473008062	Replication protein; Region: Rep_1; cl02412
548473008063	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
548473008064	potential frameshift: common BLAST hit: gi|379793812|ref|YP_005327041.1| Replication-associated protein
548473008065	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
548473008066	non-specific DNA binding site [nucleotide binding]; other site
548473008067	salt bridge; other site
548473008068	sequence-specific DNA binding site [nucleotide binding]; other site
548473008069	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
548473008070	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
548473008071	Walker A/P-loop; other site
548473008072	ATP binding site [chemical binding]; other site
548473008073	Q-loop/lid; other site
548473008074	ABC transporter signature motif; other site
548473008075	Walker B; other site
548473008076	D-loop; other site
548473008077	H-loop/switch region; other site
548473008078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
548473008079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
548473008080	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
548473008081	bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653
548473008082	multiple promoter invertase; Provisional; Region: mpi; PRK13413
548473008083	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
548473008084	catalytic residues [active]
548473008085	catalytic nucleophile [active]
548473008086	Presynaptic Site I dimer interface [polypeptide binding]; other site
548473008087	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
548473008088	Synaptic Flat tetramer interface [polypeptide binding]; other site
548473008089	Synaptic Site I dimer interface [polypeptide binding]; other site
548473008090	DNA binding site [nucleotide binding]
548473008091	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
548473008092	DNA-binding interface [nucleotide binding]; DNA binding site
548473008093	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
548473008094	beta-lactamase TEM; Provisional; Region: PRK15442
548473008095	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
548473008096	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
548473008097	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
548473008098	Predicted transcriptional regulator [Transcription]; Region: COG3682
548473008099	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
548473008100	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
548473008101	catalytic residues [active]
548473008102	catalytic nucleophile [active]
548473008103	Presynaptic Site I dimer interface [polypeptide binding]; other site
548473008104	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
548473008105	Synaptic Flat tetramer interface [polypeptide binding]; other site
548473008106	Synaptic Site I dimer interface [polypeptide binding]; other site
548473008107	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
548473008108	DNA-binding interface [nucleotide binding]; DNA binding site
548473008109	Winged helix-turn helix; Region: HTH_29; pfam13551
548473008110	Helix-turn-helix domain; Region: HTH_28; pfam13518
548473008111	Homeodomain-like domain; Region: HTH_32; pfam13565
548473008112	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
548473008113	Integrase core domain; Region: rve; pfam00665
548473008114	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
548473008115	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
548473008116	potential frameshift: common BLAST hit: gi|379793825|ref|YP_005327054.1| putative reverse transcriptase
548473008117	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
548473008118	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
548473008119	NTP binding site [chemical binding]; other site