-- dump date 20140620_075519 -- class Genbank::misc_feature -- table misc_feature_note -- id note 451515000001 Replication protein; Region: Rep_1; pfam01446 451515000002 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 451515000003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515000004 putative substrate translocation pore; other site 451515000005 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 451515000006 Replication initiation factor; Region: Rep_trans; pfam02486 451515000007 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 451515000008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 451515000009 Integrase core domain; Region: rve; pfam00665 451515000010 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 451515000011 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 451515000012 HIGH motif; other site 451515000013 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 451515000014 active site 451515000015 KMSKS motif; other site 451515000016 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 451515000017 tRNA binding surface [nucleotide binding]; other site 451515000018 anticodon binding site; other site 451515000019 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 451515000020 Phosphotransferase enzyme family; Region: APH; pfam01636 451515000021 active site 451515000022 ATP binding site [chemical binding]; other site 451515000023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 451515000024 Integrase core domain; Region: rve; pfam00665 451515000025 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 451515000026 putative switch regulator; other site 451515000027 non-specific DNA interactions [nucleotide binding]; other site 451515000028 DNA binding site [nucleotide binding] 451515000029 sequence specific DNA binding site [nucleotide binding]; other site 451515000030 putative cAMP binding site [chemical binding]; other site 451515000031 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 451515000032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515000033 S-adenosylmethionine binding site [chemical binding]; other site 451515000034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 451515000035 Integrase core domain; Region: rve; pfam00665 451515000036 Domain of unknown function DUF87; Region: DUF87; pfam01935 451515000037 AAA-like domain; Region: AAA_10; pfam12846 451515000038 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 451515000039 CHAP domain; Region: CHAP; pfam05257 451515000040 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 451515000041 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 451515000042 active site 451515000043 putative interdomain interaction site [polypeptide binding]; other site 451515000044 putative metal-binding site [ion binding]; other site 451515000045 putative nucleotide binding site [chemical binding]; other site 451515000046 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 451515000047 domain I; other site 451515000048 DNA binding groove [nucleotide binding] 451515000049 phosphate binding site [ion binding]; other site 451515000050 domain II; other site 451515000051 domain III; other site 451515000052 nucleotide binding site [chemical binding]; other site 451515000053 catalytic site [active] 451515000054 domain IV; other site 451515000055 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 451515000056 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 451515000057 Walker A motif; other site 451515000058 ATP binding site [chemical binding]; other site 451515000059 Walker B motif; other site 451515000060 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 451515000061 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 451515000062 dimer interface [polypeptide binding]; other site 451515000063 ssDNA binding site [nucleotide binding]; other site 451515000064 tetramer (dimer of dimers) interface [polypeptide binding]; other site 451515000065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 451515000066 Integrase core domain; Region: rve; pfam00665 451515000067 Predicted membrane protein [Function unknown]; Region: COG4640 451515000068 YolD-like protein; Region: YolD; pfam08863 451515000069 multiple promoter invertase; Provisional; Region: mpi; PRK13413 451515000070 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 451515000071 catalytic residues [active] 451515000072 catalytic nucleophile [active] 451515000073 Presynaptic Site I dimer interface [polypeptide binding]; other site 451515000074 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 451515000075 Synaptic Flat tetramer interface [polypeptide binding]; other site 451515000076 Synaptic Site I dimer interface [polypeptide binding]; other site 451515000077 DNA binding site [nucleotide binding] 451515000078 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 451515000079 DNA-binding interface [nucleotide binding]; DNA binding site 451515000080 MobA/MobL family; Region: MobA_MobL; pfam03389 451515000081 plasmid segregation protein ParM; Provisional; Region: PRK13917 451515000082 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 451515000083 Mg binding site [ion binding]; other site 451515000084 nucleotide binding site [chemical binding]; other site 451515000085 putative protofilament interface [polypeptide binding]; other site 451515000086 plasmid segregation protein ParR; Provisional; Region: PRK13916 451515000087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515000088 non-specific DNA binding site [nucleotide binding]; other site 451515000089 salt bridge; other site 451515000090 sequence-specific DNA binding site [nucleotide binding]; other site 451515000091 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 451515000092 DnaA N-terminal domain; Region: DnaA_N; pfam11638 451515000093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515000094 Walker A motif; other site 451515000095 ATP binding site [chemical binding]; other site 451515000096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 451515000097 Walker B motif; other site 451515000098 arginine finger; other site 451515000099 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 451515000100 DnaA box-binding interface [nucleotide binding]; other site 451515000101 DNA polymerase III subunit beta; Validated; Region: PRK05643 451515000102 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 451515000103 putative DNA binding surface [nucleotide binding]; other site 451515000104 dimer interface [polypeptide binding]; other site 451515000105 beta-clamp/clamp loader binding surface; other site 451515000106 beta-clamp/translesion DNA polymerase binding surface; other site 451515000107 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 451515000108 recF protein; Region: recf; TIGR00611 451515000109 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 451515000110 Walker A/P-loop; other site 451515000111 ATP binding site [chemical binding]; other site 451515000112 Q-loop/lid; other site 451515000113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515000114 ABC transporter signature motif; other site 451515000115 Walker B; other site 451515000116 D-loop; other site 451515000117 H-loop/switch region; other site 451515000118 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 451515000119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515000120 Mg2+ binding site [ion binding]; other site 451515000121 G-X-G motif; other site 451515000122 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 451515000123 anchoring element; other site 451515000124 dimer interface [polypeptide binding]; other site 451515000125 ATP binding site [chemical binding]; other site 451515000126 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 451515000127 active site 451515000128 putative metal-binding site [ion binding]; other site 451515000129 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 451515000130 DNA gyrase subunit A; Validated; Region: PRK05560 451515000131 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 451515000132 CAP-like domain; other site 451515000133 active site 451515000134 primary dimer interface [polypeptide binding]; other site 451515000135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 451515000136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 451515000137 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 451515000138 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 451515000139 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 451515000140 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 451515000141 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 451515000142 putative substrate binding site [chemical binding]; other site 451515000143 putative ATP binding site [chemical binding]; other site 451515000144 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 451515000145 active sites [active] 451515000146 tetramer interface [polypeptide binding]; other site 451515000147 seryl-tRNA synthetase; Provisional; Region: PRK05431 451515000148 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 451515000149 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 451515000150 dimer interface [polypeptide binding]; other site 451515000151 active site 451515000152 motif 1; other site 451515000153 motif 2; other site 451515000154 motif 3; other site 451515000155 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 451515000156 Predicted membrane protein [Function unknown]; Region: COG4392 451515000157 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 451515000158 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 451515000159 Predicted membrane protein [Function unknown]; Region: COG4241 451515000160 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 451515000161 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 451515000162 DHH family; Region: DHH; pfam01368 451515000163 DHHA1 domain; Region: DHHA1; pfam02272 451515000164 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 451515000165 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 451515000166 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 451515000167 replicative DNA helicase; Region: DnaB; TIGR00665 451515000168 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 451515000169 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 451515000170 Walker A motif; other site 451515000171 ATP binding site [chemical binding]; other site 451515000172 Walker B motif; other site 451515000173 DNA binding loops [nucleotide binding] 451515000174 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 451515000175 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 451515000176 GDP-binding site [chemical binding]; other site 451515000177 ACT binding site; other site 451515000178 IMP binding site; other site 451515000179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 451515000180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515000181 active site 451515000182 phosphorylation site [posttranslational modification] 451515000183 intermolecular recognition site; other site 451515000184 dimerization interface [polypeptide binding]; other site 451515000185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 451515000186 DNA binding site [nucleotide binding] 451515000187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 451515000188 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 451515000189 dimerization interface [polypeptide binding]; other site 451515000190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 451515000191 putative active site [active] 451515000192 heme pocket [chemical binding]; other site 451515000193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 451515000194 dimer interface [polypeptide binding]; other site 451515000195 phosphorylation site [posttranslational modification] 451515000196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515000197 ATP binding site [chemical binding]; other site 451515000198 Mg2+ binding site [ion binding]; other site 451515000199 G-X-G motif; other site 451515000200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 451515000201 YycH protein; Region: YycH; pfam07435 451515000202 YycH protein; Region: YycI; cl02015 451515000203 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 451515000204 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 451515000205 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 451515000206 putative active site [active] 451515000207 putative metal binding site [ion binding]; other site 451515000208 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 451515000209 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 451515000210 SCCmecIV 451515000211 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 451515000212 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 451515000213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 451515000214 Integrase core domain; Region: rve; pfam00665 451515000215 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 451515000216 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 451515000217 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 451515000218 putative active site [active] 451515000219 catalytic site [active] 451515000220 putative metal binding site [ion binding]; other site 451515000221 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 451515000222 putative active site [active] 451515000223 putative catalytic site [active] 451515000224 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 451515000225 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 451515000226 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 451515000227 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 451515000228 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 451515000229 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 451515000230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 451515000231 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 451515000232 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 451515000233 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 451515000234 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 451515000235 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 451515000236 catalytic residues [active] 451515000237 catalytic nucleophile [active] 451515000238 Presynaptic Site I dimer interface [polypeptide binding]; other site 451515000239 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 451515000240 Synaptic Flat tetramer interface [polypeptide binding]; other site 451515000241 Synaptic Site I dimer interface [polypeptide binding]; other site 451515000242 DNA binding site [nucleotide binding] 451515000243 Recombinase; Region: Recombinase; pfam07508 451515000244 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 451515000245 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 451515000246 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 451515000247 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 451515000248 catalytic residues [active] 451515000249 catalytic nucleophile [active] 451515000250 Recombinase; Region: Recombinase; pfam07508 451515000251 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 451515000252 Domain of unknown function (DUF927); Region: DUF927; pfam06048 451515000253 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 451515000254 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 451515000255 Divergent AAA domain; Region: AAA_4; pfam04326 451515000256 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 451515000257 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 451515000258 active site residue [active] 451515000259 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 451515000260 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 451515000261 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 451515000262 active site 451515000263 ACME 451515000264 HNH endonuclease; Region: HNH_2; pfam13391 451515000265 Tic20-like protein; Region: Tic20; pfam09685 451515000266 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 451515000267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515000268 Coenzyme A binding pocket [chemical binding]; other site 451515000269 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 451515000270 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 451515000271 NAD binding site [chemical binding]; other site 451515000272 catalytic Zn binding site [ion binding]; other site 451515000273 substrate binding site [chemical binding]; other site 451515000274 structural Zn binding site [ion binding]; other site 451515000275 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 451515000276 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 451515000277 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 451515000278 putative transposase OrfB; Reviewed; Region: PHA02517 451515000279 HTH-like domain; Region: HTH_21; pfam13276 451515000280 Integrase core domain; Region: rve; pfam00665 451515000281 Integrase core domain; Region: rve_3; cl15866 451515000282 carbamate kinase; Reviewed; Region: PRK12686 451515000283 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 451515000284 putative substrate binding site [chemical binding]; other site 451515000285 nucleotide binding site [chemical binding]; other site 451515000286 nucleotide binding site [chemical binding]; other site 451515000287 homodimer interface [polypeptide binding]; other site 451515000288 ornithine carbamoyltransferase; Provisional; Region: PRK04284 451515000289 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 451515000290 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 451515000291 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 451515000292 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 451515000293 ligand binding site [chemical binding]; other site 451515000294 flexible hinge region; other site 451515000295 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 451515000296 putative switch regulator; other site 451515000297 non-specific DNA interactions [nucleotide binding]; other site 451515000298 DNA binding site [nucleotide binding] 451515000299 sequence specific DNA binding site [nucleotide binding]; other site 451515000300 putative cAMP binding site [chemical binding]; other site 451515000301 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 451515000302 arginine deiminase; Provisional; Region: PRK01388 451515000303 Arginine repressor [Transcription]; Region: ArgR; COG1438 451515000304 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 451515000305 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 451515000306 Ligand Binding Site [chemical binding]; other site 451515000307 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 451515000308 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 451515000309 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 451515000310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 451515000311 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 451515000312 Methyltransferase domain; Region: Methyltransf_23; pfam13489 451515000313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515000314 S-adenosylmethionine binding site [chemical binding]; other site 451515000315 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 451515000316 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 451515000317 substrate binding site [chemical binding]; other site 451515000318 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 451515000319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515000320 dimer interface [polypeptide binding]; other site 451515000321 conserved gate region; other site 451515000322 putative PBP binding loops; other site 451515000323 ABC-ATPase subunit interface; other site 451515000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 451515000325 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 451515000326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515000327 dimer interface [polypeptide binding]; other site 451515000328 conserved gate region; other site 451515000329 putative PBP binding loops; other site 451515000330 ABC-ATPase subunit interface; other site 451515000331 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 451515000332 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515000333 Walker A/P-loop; other site 451515000334 ATP binding site [chemical binding]; other site 451515000335 Q-loop/lid; other site 451515000336 ABC transporter signature motif; other site 451515000337 Walker B; other site 451515000338 D-loop; other site 451515000339 H-loop/switch region; other site 451515000340 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 451515000341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515000342 Walker A/P-loop; other site 451515000343 ATP binding site [chemical binding]; other site 451515000344 Q-loop/lid; other site 451515000345 ABC transporter signature motif; other site 451515000346 Walker B; other site 451515000347 D-loop; other site 451515000348 H-loop/switch region; other site 451515000349 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 451515000350 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 451515000351 Soluble P-type ATPase [General function prediction only]; Region: COG4087 451515000352 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 451515000353 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 451515000354 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 451515000355 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 451515000356 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 451515000357 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 451515000358 phosphate binding site [ion binding]; other site 451515000359 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 451515000360 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 451515000361 putative homodimer interface [polypeptide binding]; other site 451515000362 putative homotetramer interface [polypeptide binding]; other site 451515000363 putative metal binding site [ion binding]; other site 451515000364 putative homodimer-homodimer interface [polypeptide binding]; other site 451515000365 putative allosteric switch controlling residues; other site 451515000366 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 451515000367 active site residue [active] 451515000368 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 451515000369 CPxP motif; other site 451515000370 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 451515000371 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 451515000372 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 451515000373 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 451515000374 active site residue [active] 451515000375 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 451515000376 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 451515000377 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 451515000378 FMN binding site [chemical binding]; other site 451515000379 active site 451515000380 catalytic residues [active] 451515000381 substrate binding site [chemical binding]; other site 451515000382 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 451515000383 H+ Antiporter protein; Region: 2A0121; TIGR00900 451515000384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515000385 putative substrate translocation pore; other site 451515000386 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 451515000387 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 451515000388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 451515000389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 451515000390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 451515000391 dimerization interface [polypeptide binding]; other site 451515000392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 451515000393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 451515000394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 451515000395 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 451515000396 Part of AAA domain; Region: AAA_19; pfam13245 451515000397 AAA domain; Region: AAA_12; pfam13087 451515000398 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 451515000399 active site 451515000400 catalytic site [active] 451515000401 putative metal binding site [ion binding]; other site 451515000402 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515000403 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515000404 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515000405 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515000406 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 451515000407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 451515000408 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 451515000409 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 451515000410 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 451515000411 metal binding site [ion binding]; metal-binding site 451515000412 dimer interface [polypeptide binding]; other site 451515000413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515000414 Major Facilitator Superfamily; Region: MFS_1; pfam07690 451515000415 putative substrate translocation pore; other site 451515000416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515000417 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 451515000418 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 451515000419 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 451515000420 PhoU domain; Region: PhoU; pfam01895 451515000421 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 451515000422 EamA-like transporter family; Region: EamA; pfam00892 451515000423 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 451515000424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 451515000425 DNA-binding site [nucleotide binding]; DNA binding site 451515000426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 451515000427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515000428 homodimer interface [polypeptide binding]; other site 451515000429 catalytic residue [active] 451515000430 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 451515000431 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 451515000432 L-lactate permease; Region: Lactate_perm; cl00701 451515000433 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515000434 B domain; Region: B; pfam02216 451515000435 B domain; Region: B; pfam02216 451515000436 B domain; Region: B; pfam02216 451515000437 B domain; Region: B; pfam02216 451515000438 B domain; Region: B; pfam02216 451515000439 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 451515000440 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515000441 Transcriptional regulators [Transcription]; Region: MarR; COG1846 451515000442 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515000443 Transcriptional regulators [Transcription]; Region: MarR; COG1846 451515000444 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 451515000445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515000446 ABC-ATPase subunit interface; other site 451515000447 dimer interface [polypeptide binding]; other site 451515000448 putative PBP binding regions; other site 451515000449 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 451515000450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515000451 ABC-ATPase subunit interface; other site 451515000452 dimer interface [polypeptide binding]; other site 451515000453 putative PBP binding regions; other site 451515000454 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 451515000455 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 451515000456 siderophore binding site; other site 451515000457 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 451515000458 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 451515000459 dimer interface [polypeptide binding]; other site 451515000460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515000461 catalytic residue [active] 451515000462 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 451515000463 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 451515000464 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 451515000465 IucA / IucC family; Region: IucA_IucC; pfam04183 451515000466 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 451515000467 drug efflux system protein MdtG; Provisional; Region: PRK09874 451515000468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515000469 putative substrate translocation pore; other site 451515000470 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 451515000471 IucA / IucC family; Region: IucA_IucC; pfam04183 451515000472 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 451515000473 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 451515000474 IucA / IucC family; Region: IucA_IucC; pfam04183 451515000475 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 451515000476 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 451515000477 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 451515000478 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 451515000479 dimer interface [polypeptide binding]; other site 451515000480 active site 451515000481 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 451515000482 catalytic residues [active] 451515000483 substrate binding site [chemical binding]; other site 451515000484 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 451515000485 ParB-like nuclease domain; Region: ParBc; pfam02195 451515000486 acetoin reductase; Validated; Region: PRK08643 451515000487 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 451515000488 NAD binding site [chemical binding]; other site 451515000489 homotetramer interface [polypeptide binding]; other site 451515000490 homodimer interface [polypeptide binding]; other site 451515000491 active site 451515000492 substrate binding site [chemical binding]; other site 451515000493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 451515000494 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 451515000495 NAD(P) binding site [chemical binding]; other site 451515000496 active site 451515000497 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 451515000498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 451515000499 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 451515000500 putative ADP-binding pocket [chemical binding]; other site 451515000501 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 451515000502 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 451515000503 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 451515000504 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 451515000505 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 451515000506 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 451515000507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 451515000508 DNA-binding site [nucleotide binding]; DNA binding site 451515000509 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 451515000510 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 451515000511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 451515000512 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 451515000513 intersubunit interface [polypeptide binding]; other site 451515000514 active site 451515000515 catalytic residue [active] 451515000516 phosphopentomutase; Provisional; Region: PRK05362 451515000517 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 451515000518 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 451515000519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515000520 dimer interface [polypeptide binding]; other site 451515000521 conserved gate region; other site 451515000522 putative PBP binding loops; other site 451515000523 ABC-ATPase subunit interface; other site 451515000524 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 451515000525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515000526 dimer interface [polypeptide binding]; other site 451515000527 conserved gate region; other site 451515000528 ABC-ATPase subunit interface; other site 451515000529 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 451515000530 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 451515000531 Walker A/P-loop; other site 451515000532 ATP binding site [chemical binding]; other site 451515000533 Q-loop/lid; other site 451515000534 ABC transporter signature motif; other site 451515000535 Walker B; other site 451515000536 D-loop; other site 451515000537 H-loop/switch region; other site 451515000538 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 451515000539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 451515000540 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 451515000541 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 451515000542 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 451515000543 active site 451515000544 metal binding site [ion binding]; metal-binding site 451515000545 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 451515000546 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 451515000547 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 451515000548 putative catalytic cysteine [active] 451515000549 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 451515000550 putative active site [active] 451515000551 metal binding site [ion binding]; metal-binding site 451515000552 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 451515000553 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 451515000554 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 451515000555 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 451515000556 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 451515000557 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 451515000558 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 451515000559 NAD(P) binding site [chemical binding]; other site 451515000560 homodimer interface [polypeptide binding]; other site 451515000561 substrate binding site [chemical binding]; other site 451515000562 active site 451515000563 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 451515000564 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 451515000565 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 451515000566 putative NAD(P) binding site [chemical binding]; other site 451515000567 active site 451515000568 putative substrate binding site [chemical binding]; other site 451515000569 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 451515000570 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 451515000571 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 451515000572 active site 451515000573 homodimer interface [polypeptide binding]; other site 451515000574 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 451515000575 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 451515000576 trimer interface [polypeptide binding]; other site 451515000577 active site 451515000578 substrate binding site [chemical binding]; other site 451515000579 CoA binding site [chemical binding]; other site 451515000580 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 451515000581 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 451515000582 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 451515000583 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 451515000584 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 451515000585 Bacterial sugar transferase; Region: Bac_transf; pfam02397 451515000586 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 451515000587 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 451515000588 putative NAD(P) binding site [chemical binding]; other site 451515000589 active site 451515000590 putative substrate binding site [chemical binding]; other site 451515000591 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 451515000592 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 451515000593 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 451515000594 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 451515000595 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 451515000596 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 451515000597 active site 451515000598 homodimer interface [polypeptide binding]; other site 451515000599 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 451515000600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 451515000601 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 451515000602 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 451515000603 NAD(P) binding site [chemical binding]; other site 451515000604 catalytic residues [active] 451515000605 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 451515000606 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 451515000607 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 451515000608 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 451515000609 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 451515000610 Walker A/P-loop; other site 451515000611 ATP binding site [chemical binding]; other site 451515000612 Q-loop/lid; other site 451515000613 ABC transporter signature motif; other site 451515000614 Walker B; other site 451515000615 D-loop; other site 451515000616 H-loop/switch region; other site 451515000617 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 451515000618 NMT1-like family; Region: NMT1_2; pfam13379 451515000619 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 451515000620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 451515000621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 451515000622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 451515000623 active site 451515000624 Uncharacterized conserved protein [Function unknown]; Region: COG5609 451515000625 formate dehydrogenase; Provisional; Region: PRK07574 451515000626 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 451515000627 dimerization interface [polypeptide binding]; other site 451515000628 ligand binding site [chemical binding]; other site 451515000629 NAD binding site [chemical binding]; other site 451515000630 catalytic site [active] 451515000631 putative transporter; Provisional; Region: PRK10054 451515000632 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 451515000633 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 451515000634 acyl-activating enzyme (AAE) consensus motif; other site 451515000635 AMP binding site [chemical binding]; other site 451515000636 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 451515000637 Condensation domain; Region: Condensation; pfam00668 451515000638 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 451515000639 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 451515000640 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 451515000641 acyl-activating enzyme (AAE) consensus motif; other site 451515000642 AMP binding site [chemical binding]; other site 451515000643 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 451515000644 thioester reductase domain; Region: Thioester-redct; TIGR01746 451515000645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 451515000646 NAD(P) binding site [chemical binding]; other site 451515000647 active site 451515000648 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 451515000649 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 451515000650 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 451515000651 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 451515000652 nucleotide binding site [chemical binding]; other site 451515000653 N-acetyl-L-glutamate binding site [chemical binding]; other site 451515000654 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 451515000655 heterotetramer interface [polypeptide binding]; other site 451515000656 active site pocket [active] 451515000657 cleavage site 451515000658 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 451515000659 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 451515000660 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 451515000661 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 451515000662 inhibitor-cofactor binding pocket; inhibition site 451515000663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515000664 catalytic residue [active] 451515000665 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 451515000666 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 451515000667 Isochorismatase family; Region: Isochorismatase; pfam00857 451515000668 catalytic triad [active] 451515000669 conserved cis-peptide bond; other site 451515000670 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 451515000671 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 451515000672 dimer interface [polypeptide binding]; other site 451515000673 PYR/PP interface [polypeptide binding]; other site 451515000674 TPP binding site [chemical binding]; other site 451515000675 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 451515000676 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 451515000677 TPP-binding site [chemical binding]; other site 451515000678 dimer interface [polypeptide binding]; other site 451515000679 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 451515000680 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 451515000681 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 451515000682 active site turn [active] 451515000683 phosphorylation site [posttranslational modification] 451515000684 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 451515000685 HPr interaction site; other site 451515000686 glycerol kinase (GK) interaction site [polypeptide binding]; other site 451515000687 active site 451515000688 phosphorylation site [posttranslational modification] 451515000689 Uncharacterized conserved protein [Function unknown]; Region: COG3589 451515000690 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 451515000691 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 451515000692 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 451515000693 putative active site [active] 451515000694 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 451515000695 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 451515000696 active site turn [active] 451515000697 phosphorylation site [posttranslational modification] 451515000698 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 451515000699 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 451515000700 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 451515000701 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 451515000702 putative active site [active] 451515000703 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 451515000704 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 451515000705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515000706 ATP binding site [chemical binding]; other site 451515000707 putative Mg++ binding site [ion binding]; other site 451515000708 RES domain; Region: RES; pfam08808 451515000709 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 451515000710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515000711 Walker A/P-loop; other site 451515000712 ATP binding site [chemical binding]; other site 451515000713 Q-loop/lid; other site 451515000714 ABC transporter signature motif; other site 451515000715 Walker B; other site 451515000716 D-loop; other site 451515000717 H-loop/switch region; other site 451515000718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 451515000719 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515000720 Walker A/P-loop; other site 451515000721 ATP binding site [chemical binding]; other site 451515000722 Q-loop/lid; other site 451515000723 ABC transporter signature motif; other site 451515000724 Walker B; other site 451515000725 D-loop; other site 451515000726 H-loop/switch region; other site 451515000727 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 451515000728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515000729 dimer interface [polypeptide binding]; other site 451515000730 conserved gate region; other site 451515000731 putative PBP binding loops; other site 451515000732 ABC-ATPase subunit interface; other site 451515000733 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 451515000734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515000735 dimer interface [polypeptide binding]; other site 451515000736 conserved gate region; other site 451515000737 ABC-ATPase subunit interface; other site 451515000738 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 451515000739 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 451515000740 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 451515000741 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 451515000742 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 451515000743 Protein of unknown function, DUF576; Region: DUF576; cl04553 451515000744 azoreductase; Reviewed; Region: PRK00170 451515000745 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 451515000746 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 451515000747 Peptidase family M23; Region: Peptidase_M23; pfam01551 451515000748 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 451515000749 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 451515000750 Walker A/P-loop; other site 451515000751 ATP binding site [chemical binding]; other site 451515000752 Q-loop/lid; other site 451515000753 ABC transporter signature motif; other site 451515000754 Walker B; other site 451515000755 D-loop; other site 451515000756 H-loop/switch region; other site 451515000757 TOBE domain; Region: TOBE; pfam03459 451515000758 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 451515000759 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 451515000760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515000761 dimer interface [polypeptide binding]; other site 451515000762 conserved gate region; other site 451515000763 ABC-ATPase subunit interface; other site 451515000764 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 451515000765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515000766 dimer interface [polypeptide binding]; other site 451515000767 conserved gate region; other site 451515000768 putative PBP binding loops; other site 451515000769 ABC-ATPase subunit interface; other site 451515000770 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 451515000771 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 451515000772 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 451515000773 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 451515000774 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 451515000775 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 451515000776 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 451515000777 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 451515000778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 451515000779 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 451515000780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515000781 putative substrate translocation pore; other site 451515000782 Response regulator receiver domain; Region: Response_reg; pfam00072 451515000783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515000784 active site 451515000785 phosphorylation site [posttranslational modification] 451515000786 intermolecular recognition site; other site 451515000787 dimerization interface [polypeptide binding]; other site 451515000788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 451515000789 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 451515000790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 451515000791 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 451515000792 Histidine kinase; Region: His_kinase; pfam06580 451515000793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515000794 ATP binding site [chemical binding]; other site 451515000795 Mg2+ binding site [ion binding]; other site 451515000796 G-X-G motif; other site 451515000797 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 451515000798 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 451515000799 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 451515000800 Pyruvate formate lyase 1; Region: PFL1; cd01678 451515000801 coenzyme A binding site [chemical binding]; other site 451515000802 active site 451515000803 catalytic residues [active] 451515000804 glycine loop; other site 451515000805 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 451515000806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515000807 FeS/SAM binding site; other site 451515000808 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 451515000809 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 451515000810 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 451515000811 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 451515000812 putative active site [active] 451515000813 catalytic site [active] 451515000814 putative metal binding site [ion binding]; other site 451515000815 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 451515000816 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 451515000817 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 451515000818 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 451515000819 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 451515000820 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 451515000821 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 451515000822 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 451515000823 dimer interface [polypeptide binding]; other site 451515000824 active site 451515000825 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 451515000826 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 451515000827 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 451515000828 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 451515000829 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 451515000830 substrate binding site [chemical binding]; other site 451515000831 oxyanion hole (OAH) forming residues; other site 451515000832 trimer interface [polypeptide binding]; other site 451515000833 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 451515000834 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 451515000835 active site 451515000836 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 451515000837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 451515000838 acyl-activating enzyme (AAE) consensus motif; other site 451515000839 AMP binding site [chemical binding]; other site 451515000840 active site 451515000841 CoA binding site [chemical binding]; other site 451515000842 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 451515000843 Coenzyme A transferase; Region: CoA_trans; smart00882 451515000844 Coenzyme A transferase; Region: CoA_trans; cl17247 451515000845 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 451515000846 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 451515000847 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 451515000848 Uncharacterized conserved protein [Function unknown]; Region: COG3189 451515000849 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 451515000850 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 451515000851 heme-binding site [chemical binding]; other site 451515000852 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 451515000853 FAD binding pocket [chemical binding]; other site 451515000854 FAD binding motif [chemical binding]; other site 451515000855 phosphate binding motif [ion binding]; other site 451515000856 beta-alpha-beta structure motif; other site 451515000857 NAD binding pocket [chemical binding]; other site 451515000858 Heme binding pocket [chemical binding]; other site 451515000859 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 451515000860 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 451515000861 dimer interface [polypeptide binding]; other site 451515000862 tetramer (dimer of dimers) interface [polypeptide binding]; other site 451515000863 NAD binding site [chemical binding]; other site 451515000864 substrate binding site [chemical binding]; other site 451515000865 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 451515000866 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 451515000867 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 451515000868 active site turn [active] 451515000869 phosphorylation site [posttranslational modification] 451515000870 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 451515000871 active site 451515000872 tetramer interface [polypeptide binding]; other site 451515000873 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 451515000874 Mga helix-turn-helix domain; Region: Mga; pfam05043 451515000875 PRD domain; Region: PRD; pfam00874 451515000876 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 451515000877 active site 451515000878 P-loop; other site 451515000879 phosphorylation site [posttranslational modification] 451515000880 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 451515000881 active site 451515000882 phosphorylation site [posttranslational modification] 451515000883 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 451515000884 active site 451515000885 phosphorylation site [posttranslational modification] 451515000886 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 451515000887 active site 451515000888 P-loop; other site 451515000889 phosphorylation site [posttranslational modification] 451515000890 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 451515000891 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 451515000892 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 451515000893 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 451515000894 putative NAD(P) binding site [chemical binding]; other site 451515000895 catalytic Zn binding site [ion binding]; other site 451515000896 structural Zn binding site [ion binding]; other site 451515000897 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 451515000898 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 451515000899 putative NAD(P) binding site [chemical binding]; other site 451515000900 catalytic Zn binding site [ion binding]; other site 451515000901 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 451515000902 substrate binding site; other site 451515000903 dimer interface; other site 451515000904 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 451515000905 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 451515000906 putative NAD(P) binding site [chemical binding]; other site 451515000907 putative catalytic Zn binding site [ion binding]; other site 451515000908 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 451515000909 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 451515000910 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 451515000911 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 451515000912 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 451515000913 substrate binding site; other site 451515000914 dimer interface; other site 451515000915 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 451515000916 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 451515000917 putative NAD(P) binding site [chemical binding]; other site 451515000918 putative catalytic Zn binding site [ion binding]; other site 451515000919 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 451515000920 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 451515000921 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 451515000922 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 451515000923 active site 451515000924 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 451515000925 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 451515000926 Hemerythrin-like domain; Region: Hr-like; cd12108 451515000927 Fe binding site [ion binding]; other site 451515000928 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 451515000929 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 451515000930 Histidine kinase; Region: His_kinase; pfam06580 451515000931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515000932 Mg2+ binding site [ion binding]; other site 451515000933 G-X-G motif; other site 451515000934 two-component response regulator; Provisional; Region: PRK14084 451515000935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515000936 active site 451515000937 phosphorylation site [posttranslational modification] 451515000938 intermolecular recognition site; other site 451515000939 dimerization interface [polypeptide binding]; other site 451515000940 LytTr DNA-binding domain; Region: LytTR; pfam04397 451515000941 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 451515000942 antiholin-like protein LrgB; Provisional; Region: PRK04288 451515000943 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 451515000944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 451515000945 DNA-binding site [nucleotide binding]; DNA binding site 451515000946 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 451515000947 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 451515000948 active site turn [active] 451515000949 phosphorylation site [posttranslational modification] 451515000950 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 451515000951 HPr interaction site; other site 451515000952 glycerol kinase (GK) interaction site [polypeptide binding]; other site 451515000953 active site 451515000954 phosphorylation site [posttranslational modification] 451515000955 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 451515000956 beta-galactosidase; Region: BGL; TIGR03356 451515000957 Methyltransferase domain; Region: Methyltransf_31; pfam13847 451515000958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515000959 S-adenosylmethionine binding site [chemical binding]; other site 451515000960 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 451515000961 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 451515000962 substrate binding site [chemical binding]; other site 451515000963 dimer interface [polypeptide binding]; other site 451515000964 ATP binding site [chemical binding]; other site 451515000965 D-ribose pyranase; Provisional; Region: PRK11797 451515000966 Sugar transport protein; Region: Sugar_transport; pfam06800 451515000967 Transcriptional regulators [Transcription]; Region: PurR; COG1609 451515000968 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 451515000969 DNA binding site [nucleotide binding] 451515000970 domain linker motif; other site 451515000971 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 451515000972 dimerization interface [polypeptide binding]; other site 451515000973 ligand binding site [chemical binding]; other site 451515000974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 451515000975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515000976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515000977 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 451515000978 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 451515000979 active site 451515000980 Surface antigen [General function prediction only]; Region: COG3942 451515000981 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 451515000982 Peptidase family M23; Region: Peptidase_M23; pfam01551 451515000983 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 451515000984 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 451515000985 Walker A/P-loop; other site 451515000986 ATP binding site [chemical binding]; other site 451515000987 Q-loop/lid; other site 451515000988 ABC transporter signature motif; other site 451515000989 Walker B; other site 451515000990 D-loop; other site 451515000991 H-loop/switch region; other site 451515000992 Surface antigen [General function prediction only]; Region: COG3942 451515000993 CHAP domain; Region: CHAP; pfam05257 451515000994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 451515000995 Predicted membrane protein [Function unknown]; Region: COG1511 451515000996 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 451515000997 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 451515000998 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 451515000999 Uncharacterized small protein [Function unknown]; Region: COG5417 451515001000 Predicted membrane protein [Function unknown]; Region: COG4499 451515001001 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 451515001002 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 451515001003 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 451515001004 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 451515001005 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 451515001006 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 451515001007 Uncharacterized conserved protein [Function unknown]; Region: COG5444 451515001008 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 451515001009 Protein of unknown function, DUF600; Region: DUF600; cl04640 451515001010 Protein of unknown function, DUF600; Region: DUF600; cl04640 451515001011 Protein of unknown function, DUF600; Region: DUF600; cl04640 451515001012 Protein of unknown function, DUF600; Region: DUF600; cl04640 451515001013 Protein of unknown function, DUF600; Region: DUF600; cl04640 451515001014 Protein of unknown function, DUF600; Region: DUF600; cl04640 451515001015 Protein of unknown function, DUF600; Region: DUF600; cl04640 451515001016 Protein of unknown function, DUF600; Region: DUF600; cl04640 451515001017 Protein of unknown function, DUF600; Region: DUF600; cl04640 451515001018 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 451515001019 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 451515001020 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 451515001021 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 451515001022 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 451515001023 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 451515001024 FtsX-like permease family; Region: FtsX; pfam02687 451515001025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 451515001026 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 451515001027 Walker A/P-loop; other site 451515001028 ATP binding site [chemical binding]; other site 451515001029 Q-loop/lid; other site 451515001030 ABC transporter signature motif; other site 451515001031 Walker B; other site 451515001032 D-loop; other site 451515001033 H-loop/switch region; other site 451515001034 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 451515001035 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 451515001036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515001037 non-specific DNA binding site [nucleotide binding]; other site 451515001038 salt bridge; other site 451515001039 sequence-specific DNA binding site [nucleotide binding]; other site 451515001040 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 451515001041 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 451515001042 substrate binding site [chemical binding]; other site 451515001043 ATP binding site [chemical binding]; other site 451515001044 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 451515001045 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 451515001046 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 451515001047 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 451515001048 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 451515001049 putative transporter; Provisional; Region: PRK10484 451515001050 Na binding site [ion binding]; other site 451515001051 N-acetylneuraminate lyase; Provisional; Region: PRK04147 451515001052 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 451515001053 inhibitor site; inhibition site 451515001054 active site 451515001055 dimer interface [polypeptide binding]; other site 451515001056 catalytic residue [active] 451515001057 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 451515001058 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 451515001059 nucleotide binding site [chemical binding]; other site 451515001060 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 451515001061 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 451515001062 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 451515001063 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 451515001064 putative active site [active] 451515001065 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 451515001066 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 451515001067 putative active site cavity [active] 451515001068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 451515001069 Nucleoside recognition; Region: Gate; pfam07670 451515001070 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 451515001071 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 451515001072 PGAP1-like protein; Region: PGAP1; pfam07819 451515001073 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 451515001074 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 451515001075 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 451515001076 putative active site [active] 451515001077 putative FMN binding site [chemical binding]; other site 451515001078 putative substrate binding site [chemical binding]; other site 451515001079 putative catalytic residue [active] 451515001080 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 451515001081 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 451515001082 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 451515001083 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 451515001084 lipoyl attachment site [posttranslational modification]; other site 451515001085 Replication protein C N-terminal domain; Region: RP-C; pfam03428 451515001086 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 451515001087 putative ADP-ribose binding site [chemical binding]; other site 451515001088 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 451515001089 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 451515001090 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 451515001091 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 451515001092 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 451515001093 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 451515001094 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 451515001095 NADP binding site [chemical binding]; other site 451515001096 putative substrate binding site [chemical binding]; other site 451515001097 active site 451515001098 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 451515001099 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 451515001100 active site 451515001101 P-loop; other site 451515001102 phosphorylation site [posttranslational modification] 451515001103 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 451515001104 active site 451515001105 phosphorylation site [posttranslational modification] 451515001106 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 451515001107 HTH domain; Region: HTH_11; pfam08279 451515001108 HTH domain; Region: HTH_11; pfam08279 451515001109 PRD domain; Region: PRD; pfam00874 451515001110 PRD domain; Region: PRD; pfam00874 451515001111 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 451515001112 active site 451515001113 P-loop; other site 451515001114 phosphorylation site [posttranslational modification] 451515001115 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 451515001116 active site 451515001117 phosphorylation site [posttranslational modification] 451515001118 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 451515001119 MarR family; Region: MarR_2; pfam12802 451515001120 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 451515001121 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 451515001122 MepB protein; Region: MepB; cl01985 451515001123 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 451515001124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515001125 putative substrate translocation pore; other site 451515001126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515001127 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 451515001128 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 451515001129 Zn binding site [ion binding]; other site 451515001130 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 451515001131 Zn binding site [ion binding]; other site 451515001132 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 451515001133 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 451515001134 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 451515001135 Predicted flavoprotein [General function prediction only]; Region: COG0431 451515001136 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 451515001137 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 451515001138 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 451515001139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 451515001140 Imelysin; Region: Peptidase_M75; pfam09375 451515001141 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 451515001142 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 451515001143 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 451515001144 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 451515001145 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 451515001146 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 451515001147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515001148 non-specific DNA binding site [nucleotide binding]; other site 451515001149 salt bridge; other site 451515001150 sequence-specific DNA binding site [nucleotide binding]; other site 451515001151 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 451515001152 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 451515001153 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 451515001154 Walker A/P-loop; other site 451515001155 ATP binding site [chemical binding]; other site 451515001156 Q-loop/lid; other site 451515001157 ABC transporter signature motif; other site 451515001158 Walker B; other site 451515001159 D-loop; other site 451515001160 H-loop/switch region; other site 451515001161 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 451515001162 Predicted membrane protein [Function unknown]; Region: COG4292 451515001163 putative acyltransferase; Provisional; Region: PRK05790 451515001164 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 451515001165 dimer interface [polypeptide binding]; other site 451515001166 active site 451515001167 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 451515001168 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 451515001169 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 451515001170 THF binding site; other site 451515001171 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 451515001172 substrate binding site [chemical binding]; other site 451515001173 THF binding site; other site 451515001174 zinc-binding site [ion binding]; other site 451515001175 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 451515001176 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 451515001177 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 451515001178 FAD binding site [chemical binding]; other site 451515001179 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 451515001180 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 451515001181 homodimer interface [polypeptide binding]; other site 451515001182 substrate-cofactor binding pocket; other site 451515001183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515001184 catalytic residue [active] 451515001185 cystathionine gamma-synthase; Reviewed; Region: PRK08247 451515001186 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 451515001187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 451515001188 catalytic residue [active] 451515001189 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 451515001190 ParB-like nuclease domain; Region: ParB; smart00470 451515001191 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 451515001192 Mechanosensitive ion channel; Region: MS_channel; pfam00924 451515001193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 451515001194 GTP-binding protein YchF; Reviewed; Region: PRK09601 451515001195 YchF GTPase; Region: YchF; cd01900 451515001196 G1 box; other site 451515001197 GTP/Mg2+ binding site [chemical binding]; other site 451515001198 Switch I region; other site 451515001199 G2 box; other site 451515001200 Switch II region; other site 451515001201 G3 box; other site 451515001202 G4 box; other site 451515001203 G5 box; other site 451515001204 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 451515001205 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 451515001206 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 451515001207 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 451515001208 dimer interface [polypeptide binding]; other site 451515001209 ssDNA binding site [nucleotide binding]; other site 451515001210 tetramer (dimer of dimers) interface [polypeptide binding]; other site 451515001211 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 451515001212 Abi-like protein; Region: Abi_2; pfam07751 451515001213 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 451515001215 Predicted membrane protein [Function unknown]; Region: COG3212 451515001216 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 451515001217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 451515001218 non-specific DNA binding site [nucleotide binding]; other site 451515001219 salt bridge; other site 451515001220 sequence-specific DNA binding site [nucleotide binding]; other site 451515001221 Predicted membrane protein [Function unknown]; Region: COG2261 451515001222 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 451515001223 catalytic core [active] 451515001224 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 451515001225 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 451515001226 catalytic residue [active] 451515001227 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 451515001228 catalytic residues [active] 451515001229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 451515001230 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515001231 peroxiredoxin; Region: AhpC; TIGR03137 451515001232 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 451515001233 dimer interface [polypeptide binding]; other site 451515001234 decamer (pentamer of dimers) interface [polypeptide binding]; other site 451515001235 catalytic triad [active] 451515001236 peroxidatic and resolving cysteines [active] 451515001237 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 451515001238 dimer interface [polypeptide binding]; other site 451515001239 FMN binding site [chemical binding]; other site 451515001240 NADPH bind site [chemical binding]; other site 451515001241 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 451515001242 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 451515001243 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 451515001244 active site 451515001245 xanthine permease; Region: pbuX; TIGR03173 451515001246 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 451515001247 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 451515001248 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 451515001249 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 451515001250 active site 451515001251 GMP synthase; Reviewed; Region: guaA; PRK00074 451515001252 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 451515001253 AMP/PPi binding site [chemical binding]; other site 451515001254 candidate oxyanion hole; other site 451515001255 catalytic triad [active] 451515001256 potential glutamine specificity residues [chemical binding]; other site 451515001257 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 451515001258 ATP Binding subdomain [chemical binding]; other site 451515001259 Ligand Binding sites [chemical binding]; other site 451515001260 Dimerization subdomain; other site 451515001261 vSAalpha 451515001262 PemK-like protein; Region: PemK; pfam02452 451515001263 Predicted membrane protein [Function unknown]; Region: COG3759 451515001264 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 451515001265 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 451515001266 NADP binding site [chemical binding]; other site 451515001267 superantigen-like protein; Reviewed; Region: PRK13037 451515001268 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001269 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001270 superantigen-like protein; Reviewed; Region: PRK13041 451515001271 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001272 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001273 superantigen-like protein; Reviewed; Region: PRK13335 451515001274 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001275 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001276 superantigen-like protein; Reviewed; Region: PRK13042 451515001277 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001278 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001279 superantigen-like protein 5; Reviewed; Region: PRK13035 451515001280 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001281 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001282 superantigen-like protein; Reviewed; Region: PRK13040 451515001283 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001284 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001285 superantigen-like protein 7; Reviewed; Region: PRK13346 451515001286 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001287 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001288 superantigen-like protein; Reviewed; Region: PRK13039 451515001289 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001290 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001291 superantigen-like protein; Reviewed; Region: PRK13345 451515001292 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001293 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001294 superantigen-like protein 5; Reviewed; Region: PRK13035 451515001295 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001296 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001297 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 451515001298 HsdM N-terminal domain; Region: HsdM_N; pfam12161 451515001299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515001300 S-adenosylmethionine binding site [chemical binding]; other site 451515001301 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 451515001302 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 451515001303 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 451515001304 superantigen-like protein; Reviewed; Region: PRK13036 451515001305 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 451515001306 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515001307 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515001308 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515001309 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515001310 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515001311 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515001312 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515001313 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515001314 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515001315 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515001316 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 451515001317 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 451515001318 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 451515001319 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 451515001320 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 451515001321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 451515001322 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 451515001323 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 451515001324 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 451515001325 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 451515001326 active site 451515001327 Esterase/lipase [General function prediction only]; Region: COG1647 451515001328 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 451515001329 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 451515001330 Na2 binding site [ion binding]; other site 451515001331 putative substrate binding site 1 [chemical binding]; other site 451515001332 Na binding site 1 [ion binding]; other site 451515001333 putative substrate binding site 2 [chemical binding]; other site 451515001334 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 451515001335 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 451515001336 dimer interface [polypeptide binding]; other site 451515001337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515001338 catalytic residue [active] 451515001339 cystathionine beta-lyase; Provisional; Region: PRK07671 451515001340 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 451515001341 homodimer interface [polypeptide binding]; other site 451515001342 substrate-cofactor binding pocket; other site 451515001343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515001344 catalytic residue [active] 451515001345 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 451515001346 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 451515001347 Walker A/P-loop; other site 451515001348 ATP binding site [chemical binding]; other site 451515001349 Q-loop/lid; other site 451515001350 ABC transporter signature motif; other site 451515001351 Walker B; other site 451515001352 D-loop; other site 451515001353 H-loop/switch region; other site 451515001354 NIL domain; Region: NIL; pfam09383 451515001355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515001356 dimer interface [polypeptide binding]; other site 451515001357 conserved gate region; other site 451515001358 ABC-ATPase subunit interface; other site 451515001359 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 451515001360 LysM domain; Region: LysM; pfam01476 451515001361 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 451515001362 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 451515001363 Surface antigen [General function prediction only]; Region: COG3942 451515001364 CHAP domain; Region: CHAP; pfam05257 451515001365 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 451515001366 nudix motif; other site 451515001367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515001368 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 451515001369 Coenzyme A binding pocket [chemical binding]; other site 451515001370 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 451515001371 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 451515001372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 451515001373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 451515001374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 451515001375 dimerization interface [polypeptide binding]; other site 451515001376 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 451515001377 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 451515001378 active site 451515001379 dimer interface [polypeptide binding]; other site 451515001380 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 451515001381 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 451515001382 active site 451515001383 FMN binding site [chemical binding]; other site 451515001384 substrate binding site [chemical binding]; other site 451515001385 3Fe-4S cluster binding site [ion binding]; other site 451515001386 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 451515001387 domain interface; other site 451515001388 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 451515001389 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 451515001390 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 451515001391 active site turn [active] 451515001392 phosphorylation site [posttranslational modification] 451515001393 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 451515001394 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 451515001395 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 451515001396 Ca binding site [ion binding]; other site 451515001397 active site 451515001398 catalytic site [active] 451515001399 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 451515001400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 451515001401 DNA-binding site [nucleotide binding]; DNA binding site 451515001402 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 451515001403 UTRA domain; Region: UTRA; pfam07702 451515001404 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 451515001405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515001406 Coenzyme A binding pocket [chemical binding]; other site 451515001407 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 451515001408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515001409 Walker A motif; other site 451515001410 ATP binding site [chemical binding]; other site 451515001411 Walker B motif; other site 451515001412 arginine finger; other site 451515001413 hypothetical protein; Validated; Region: PRK00153 451515001414 recombination protein RecR; Reviewed; Region: recR; PRK00076 451515001415 RecR protein; Region: RecR; pfam02132 451515001416 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 451515001417 putative active site [active] 451515001418 putative metal-binding site [ion binding]; other site 451515001419 tetramer interface [polypeptide binding]; other site 451515001420 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 451515001421 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 451515001422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 451515001423 catalytic residue [active] 451515001424 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 451515001425 thymidylate kinase; Validated; Region: tmk; PRK00698 451515001426 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 451515001427 TMP-binding site; other site 451515001428 ATP-binding site [chemical binding]; other site 451515001429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 451515001430 DNA polymerase III subunit delta'; Validated; Region: PRK08058 451515001431 DNA polymerase III subunit delta'; Validated; Region: PRK08485 451515001432 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 451515001433 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 451515001434 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 451515001435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515001436 S-adenosylmethionine binding site [chemical binding]; other site 451515001437 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 451515001438 GIY-YIG motif/motif A; other site 451515001439 putative active site [active] 451515001440 putative metal binding site [ion binding]; other site 451515001441 Predicted methyltransferases [General function prediction only]; Region: COG0313 451515001442 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 451515001443 putative SAM binding site [chemical binding]; other site 451515001444 putative homodimer interface [polypeptide binding]; other site 451515001445 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 451515001446 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 451515001447 active site 451515001448 HIGH motif; other site 451515001449 KMSKS motif; other site 451515001450 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 451515001451 tRNA binding surface [nucleotide binding]; other site 451515001452 anticodon binding site; other site 451515001453 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 451515001454 dimer interface [polypeptide binding]; other site 451515001455 putative tRNA-binding site [nucleotide binding]; other site 451515001456 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 451515001457 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 451515001458 active site 451515001459 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 451515001460 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 451515001461 putative active site [active] 451515001462 putative metal binding site [ion binding]; other site 451515001463 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 451515001464 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 451515001465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515001466 S-adenosylmethionine binding site [chemical binding]; other site 451515001467 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 451515001468 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 451515001469 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 451515001470 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 451515001471 pur operon repressor; Provisional; Region: PRK09213 451515001472 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 451515001473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 451515001474 active site 451515001475 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 451515001476 homotrimer interaction site [polypeptide binding]; other site 451515001477 putative active site [active] 451515001478 regulatory protein SpoVG; Reviewed; Region: PRK13259 451515001479 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 451515001480 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 451515001481 Substrate binding site; other site 451515001482 Mg++ binding site; other site 451515001483 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 451515001484 active site 451515001485 substrate binding site [chemical binding]; other site 451515001486 CoA binding site [chemical binding]; other site 451515001487 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 451515001488 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 451515001489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 451515001490 active site 451515001491 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 451515001492 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 451515001493 5S rRNA interface [nucleotide binding]; other site 451515001494 CTC domain interface [polypeptide binding]; other site 451515001495 L16 interface [polypeptide binding]; other site 451515001496 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 451515001497 putative active site [active] 451515001498 catalytic residue [active] 451515001499 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 451515001500 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 451515001501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515001502 ATP binding site [chemical binding]; other site 451515001503 putative Mg++ binding site [ion binding]; other site 451515001504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 451515001505 nucleotide binding region [chemical binding]; other site 451515001506 ATP-binding site [chemical binding]; other site 451515001507 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 451515001508 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 451515001509 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 451515001510 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 451515001511 putative SAM binding site [chemical binding]; other site 451515001512 putative homodimer interface [polypeptide binding]; other site 451515001513 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 451515001514 homodimer interface [polypeptide binding]; other site 451515001515 metal binding site [ion binding]; metal-binding site 451515001516 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 451515001517 RNA binding surface [nucleotide binding]; other site 451515001518 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 451515001519 Septum formation initiator; Region: DivIC; pfam04977 451515001520 hypothetical protein; Provisional; Region: PRK08582 451515001521 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 451515001522 RNA binding site [nucleotide binding]; other site 451515001523 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 451515001524 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 451515001525 Ligand Binding Site [chemical binding]; other site 451515001526 TilS substrate C-terminal domain; Region: TilS_C; smart00977 451515001527 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 451515001528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 451515001529 active site 451515001530 FtsH Extracellular; Region: FtsH_ext; pfam06480 451515001531 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 451515001532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515001533 Walker A motif; other site 451515001534 ATP binding site [chemical binding]; other site 451515001535 Walker B motif; other site 451515001536 arginine finger; other site 451515001537 Peptidase family M41; Region: Peptidase_M41; pfam01434 451515001538 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 451515001539 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 451515001540 dimerization interface [polypeptide binding]; other site 451515001541 domain crossover interface; other site 451515001542 redox-dependent activation switch; other site 451515001543 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 451515001544 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 451515001545 dimer interface [polypeptide binding]; other site 451515001546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515001547 catalytic residue [active] 451515001548 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 451515001549 dihydropteroate synthase; Region: DHPS; TIGR01496 451515001550 substrate binding pocket [chemical binding]; other site 451515001551 dimer interface [polypeptide binding]; other site 451515001552 inhibitor binding site; inhibition site 451515001553 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 451515001554 homooctamer interface [polypeptide binding]; other site 451515001555 active site 451515001556 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 451515001557 catalytic center binding site [active] 451515001558 ATP binding site [chemical binding]; other site 451515001559 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 451515001560 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 451515001561 dimer interface [polypeptide binding]; other site 451515001562 putative anticodon binding site; other site 451515001563 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 451515001564 motif 1; other site 451515001565 active site 451515001566 motif 2; other site 451515001567 motif 3; other site 451515001568 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 451515001569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 451515001570 DNA-binding site [nucleotide binding]; DNA binding site 451515001571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 451515001572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515001573 homodimer interface [polypeptide binding]; other site 451515001574 catalytic residue [active] 451515001575 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 451515001576 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 451515001577 active site 451515001578 multimer interface [polypeptide binding]; other site 451515001579 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 451515001580 predicted active site [active] 451515001581 catalytic triad [active] 451515001582 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 451515001583 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 451515001584 Nucleoside recognition; Region: Gate; pfam07670 451515001585 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 451515001586 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 451515001587 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 451515001588 UvrB/uvrC motif; Region: UVR; pfam02151 451515001589 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 451515001590 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 451515001591 ADP binding site [chemical binding]; other site 451515001592 phosphagen binding site; other site 451515001593 substrate specificity loop; other site 451515001594 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 451515001595 Clp amino terminal domain; Region: Clp_N; pfam02861 451515001596 Clp amino terminal domain; Region: Clp_N; pfam02861 451515001597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515001598 Walker A motif; other site 451515001599 ATP binding site [chemical binding]; other site 451515001600 Walker B motif; other site 451515001601 arginine finger; other site 451515001602 UvrB/uvrC motif; Region: UVR; pfam02151 451515001603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515001604 Walker A motif; other site 451515001605 ATP binding site [chemical binding]; other site 451515001606 Walker B motif; other site 451515001607 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 451515001608 DNA repair protein RadA; Provisional; Region: PRK11823 451515001609 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 451515001610 Walker A motif/ATP binding site; other site 451515001611 ATP binding site [chemical binding]; other site 451515001612 Walker B motif; other site 451515001613 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 451515001614 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 451515001615 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 451515001616 putative active site [active] 451515001617 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 451515001618 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 451515001619 active site 451515001620 HIGH motif; other site 451515001621 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 451515001622 active site 451515001623 KMSKS motif; other site 451515001624 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 451515001625 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 451515001626 trimer interface [polypeptide binding]; other site 451515001627 active site 451515001628 substrate binding site [chemical binding]; other site 451515001629 CoA binding site [chemical binding]; other site 451515001630 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 451515001631 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 451515001632 active site 451515001633 HIGH motif; other site 451515001634 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 451515001635 KMSKS motif; other site 451515001636 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 451515001637 tRNA binding surface [nucleotide binding]; other site 451515001638 anticodon binding site; other site 451515001639 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 451515001640 active site 451515001641 dimerization interface [polypeptide binding]; other site 451515001642 metal binding site [ion binding]; metal-binding site 451515001643 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 451515001644 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 451515001645 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 451515001646 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 451515001647 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 451515001648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 451515001649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 451515001650 DNA binding residues [nucleotide binding] 451515001651 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 451515001652 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 451515001653 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 451515001654 putative homodimer interface [polypeptide binding]; other site 451515001655 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 451515001656 heterodimer interface [polypeptide binding]; other site 451515001657 homodimer interface [polypeptide binding]; other site 451515001658 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 451515001659 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 451515001660 23S rRNA interface [nucleotide binding]; other site 451515001661 L7/L12 interface [polypeptide binding]; other site 451515001662 putative thiostrepton binding site; other site 451515001663 L25 interface [polypeptide binding]; other site 451515001664 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 451515001665 mRNA/rRNA interface [nucleotide binding]; other site 451515001666 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 451515001667 23S rRNA interface [nucleotide binding]; other site 451515001668 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 451515001669 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 451515001670 peripheral dimer interface [polypeptide binding]; other site 451515001671 core dimer interface [polypeptide binding]; other site 451515001672 L10 interface [polypeptide binding]; other site 451515001673 L11 interface [polypeptide binding]; other site 451515001674 putative EF-Tu interaction site [polypeptide binding]; other site 451515001675 putative EF-G interaction site [polypeptide binding]; other site 451515001676 Methyltransferase domain; Region: Methyltransf_31; pfam13847 451515001677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515001678 S-adenosylmethionine binding site [chemical binding]; other site 451515001679 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 451515001680 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 451515001681 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 451515001682 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 451515001683 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 451515001684 RPB10 interaction site [polypeptide binding]; other site 451515001685 RPB1 interaction site [polypeptide binding]; other site 451515001686 RPB11 interaction site [polypeptide binding]; other site 451515001687 RPB3 interaction site [polypeptide binding]; other site 451515001688 RPB12 interaction site [polypeptide binding]; other site 451515001689 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 451515001690 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 451515001691 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 451515001692 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 451515001693 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 451515001694 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 451515001695 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 451515001696 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 451515001697 G-loop; other site 451515001698 DNA binding site [nucleotide binding] 451515001699 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 451515001700 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 451515001701 S17 interaction site [polypeptide binding]; other site 451515001702 S8 interaction site; other site 451515001703 16S rRNA interaction site [nucleotide binding]; other site 451515001704 streptomycin interaction site [chemical binding]; other site 451515001705 23S rRNA interaction site [nucleotide binding]; other site 451515001706 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 451515001707 30S ribosomal protein S7; Validated; Region: PRK05302 451515001708 elongation factor G; Reviewed; Region: PRK00007 451515001709 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 451515001710 G1 box; other site 451515001711 putative GEF interaction site [polypeptide binding]; other site 451515001712 GTP/Mg2+ binding site [chemical binding]; other site 451515001713 Switch I region; other site 451515001714 G2 box; other site 451515001715 G3 box; other site 451515001716 Switch II region; other site 451515001717 G4 box; other site 451515001718 G5 box; other site 451515001719 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 451515001720 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 451515001721 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 451515001722 elongation factor Tu; Reviewed; Region: PRK00049 451515001723 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 451515001724 G1 box; other site 451515001725 GEF interaction site [polypeptide binding]; other site 451515001726 GTP/Mg2+ binding site [chemical binding]; other site 451515001727 Switch I region; other site 451515001728 G2 box; other site 451515001729 G3 box; other site 451515001730 Switch II region; other site 451515001731 G4 box; other site 451515001732 G5 box; other site 451515001733 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 451515001734 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 451515001735 Antibiotic Binding Site [chemical binding]; other site 451515001736 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 451515001737 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 451515001738 metal binding site [ion binding]; metal-binding site 451515001739 dimer interface [polypeptide binding]; other site 451515001740 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 451515001741 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 451515001742 substrate-cofactor binding pocket; other site 451515001743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515001744 catalytic residue [active] 451515001745 chaperone protein HchA; Provisional; Region: PRK04155 451515001746 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 451515001747 dimer interface [polypeptide binding]; other site 451515001748 metal binding site [ion binding]; metal-binding site 451515001749 potential oxyanion hole; other site 451515001750 potential catalytic triad [active] 451515001751 conserved cys residue [active] 451515001752 ribulokinase; Provisional; Region: PRK04123 451515001753 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 451515001754 N- and C-terminal domain interface [polypeptide binding]; other site 451515001755 active site 451515001756 MgATP binding site [chemical binding]; other site 451515001757 catalytic site [active] 451515001758 metal binding site [ion binding]; metal-binding site 451515001759 carbohydrate binding site [chemical binding]; other site 451515001760 homodimer interface [polypeptide binding]; other site 451515001761 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 451515001762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 451515001763 NAD(P) binding site [chemical binding]; other site 451515001764 active site 451515001765 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 451515001766 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 451515001767 homodimer interface [polypeptide binding]; other site 451515001768 substrate-cofactor binding pocket; other site 451515001769 catalytic residue [active] 451515001770 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 451515001771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515001772 motif II; other site 451515001773 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 451515001774 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 451515001775 Substrate-binding site [chemical binding]; other site 451515001776 Substrate specificity [chemical binding]; other site 451515001777 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 451515001778 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 451515001779 Substrate-binding site [chemical binding]; other site 451515001780 Substrate specificity [chemical binding]; other site 451515001781 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 451515001782 nucleoside/Zn binding site; other site 451515001783 dimer interface [polypeptide binding]; other site 451515001784 catalytic motif [active] 451515001785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515001786 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 451515001787 active site 451515001788 motif I; other site 451515001789 motif II; other site 451515001790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515001791 Predicted flavoprotein [General function prediction only]; Region: COG0431 451515001792 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 451515001793 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515001794 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 451515001795 Cna protein B-type domain; Region: Cna_B; pfam05738 451515001796 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 451515001797 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515001798 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 451515001799 Cna protein B-type domain; Region: Cna_B; pfam05738 451515001800 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 451515001801 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 451515001802 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 451515001803 Cna protein B-type domain; Region: Cna_B; pfam05738 451515001804 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515001805 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 451515001806 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 451515001807 Cna protein B-type domain; Region: Cna_B; pfam05738 451515001808 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 451515001809 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 451515001810 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 451515001811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 451515001812 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 451515001813 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 451515001814 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 451515001815 putative GTP cyclohydrolase; Provisional; Region: PRK13674 451515001816 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 451515001817 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 451515001818 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 451515001819 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 451515001820 active site 451515001821 trimer interface [polypeptide binding]; other site 451515001822 allosteric site; other site 451515001823 active site lid [active] 451515001824 hexamer (dimer of trimers) interface [polypeptide binding]; other site 451515001825 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 451515001826 active site 451515001827 dimer interface [polypeptide binding]; other site 451515001828 magnesium binding site [ion binding]; other site 451515001829 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 451515001830 tetramer interface [polypeptide binding]; other site 451515001831 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 451515001832 active site 451515001833 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 451515001834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515001835 motif II; other site 451515001836 proline/glycine betaine transporter; Provisional; Region: PRK10642 451515001837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515001838 putative substrate translocation pore; other site 451515001839 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 451515001840 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 451515001841 acyl-activating enzyme (AAE) consensus motif; other site 451515001842 AMP binding site [chemical binding]; other site 451515001843 active site 451515001844 CoA binding site [chemical binding]; other site 451515001845 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 451515001846 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 451515001847 dimer interface [polypeptide binding]; other site 451515001848 active site 451515001849 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 451515001850 dimer interface [polypeptide binding]; other site 451515001851 substrate binding site [chemical binding]; other site 451515001852 ATP binding site [chemical binding]; other site 451515001853 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 451515001854 ligand binding site [chemical binding]; other site 451515001855 active site 451515001856 UGI interface [polypeptide binding]; other site 451515001857 catalytic site [active] 451515001858 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 451515001859 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 451515001860 Uncharacterized conserved protein [Function unknown]; Region: COG3610 451515001861 Uncharacterized conserved protein [Function unknown]; Region: COG2966 451515001862 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 451515001863 putative heme peroxidase; Provisional; Region: PRK12276 451515001864 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 451515001865 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 451515001866 mevalonate kinase; Region: mevalon_kin; TIGR00549 451515001867 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 451515001868 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 451515001869 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 451515001870 diphosphomevalonate decarboxylase; Region: PLN02407 451515001871 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 451515001872 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 451515001873 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 451515001874 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 451515001875 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 451515001876 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 451515001877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515001878 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 451515001879 Predicted transcriptional regulator [Transcription]; Region: COG1959 451515001880 Transcriptional regulator; Region: Rrf2; pfam02082 451515001881 LXG domain of WXG superfamily; Region: LXG; pfam04740 451515001882 Protein of unknown function (DUF443); Region: DUF443; pfam04276 451515001883 Protein of unknown function (DUF443); Region: DUF443; pfam04276 451515001884 Protein of unknown function (DUF443); Region: DUF443; pfam04276 451515001885 Protein of unknown function (DUF443); Region: DUF443; pfam04276 451515001886 Protein of unknown function (DUF443); Region: DUF443; pfam04276 451515001887 Protein of unknown function (DUF443); Region: DUF443; pfam04276 451515001888 Protein of unknown function (DUF443); Region: DUF443; pfam04276 451515001889 Protein of unknown function (DUF443); Region: DUF443; pfam04276 451515001890 Protein of unknown function (DUF443); Region: DUF443; pfam04276 451515001891 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 451515001892 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 451515001893 active site 451515001894 catalytic tetrad [active] 451515001895 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 451515001896 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 451515001897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 451515001898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515001899 Coenzyme A binding pocket [chemical binding]; other site 451515001900 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 451515001901 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 451515001902 Zn2+ binding site [ion binding]; other site 451515001903 Mg2+ binding site [ion binding]; other site 451515001904 YwhD family; Region: YwhD; pfam08741 451515001905 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 451515001906 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 451515001907 NAD binding site [chemical binding]; other site 451515001908 substrate binding site [chemical binding]; other site 451515001909 catalytic Zn binding site [ion binding]; other site 451515001910 tetramer interface [polypeptide binding]; other site 451515001911 structural Zn binding site [ion binding]; other site 451515001912 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 451515001913 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 451515001914 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 451515001915 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 451515001916 active site 451515001917 HIGH motif; other site 451515001918 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 451515001919 KMSK motif region; other site 451515001920 tRNA binding surface [nucleotide binding]; other site 451515001921 DALR anticodon binding domain; Region: DALR_1; smart00836 451515001922 anticodon binding site; other site 451515001923 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 451515001924 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 451515001925 minor groove reading motif; other site 451515001926 helix-hairpin-helix signature motif; other site 451515001927 substrate binding pocket [chemical binding]; other site 451515001928 active site 451515001929 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 451515001930 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 451515001931 putative binding site residues; other site 451515001932 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515001933 ABC-ATPase subunit interface; other site 451515001934 dimer interface [polypeptide binding]; other site 451515001935 putative PBP binding regions; other site 451515001936 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 451515001937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515001938 motif II; other site 451515001939 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 451515001940 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 451515001941 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 451515001942 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 451515001943 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515001944 Transcriptional regulators [Transcription]; Region: MarR; COG1846 451515001945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 451515001946 Protein of unknown function, DUF606; Region: DUF606; pfam04657 451515001947 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 451515001948 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 451515001949 active site 451515001950 DNA binding site [nucleotide binding] 451515001951 Int/Topo IB signature motif; other site 451515001952 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 451515001953 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 451515001954 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 451515001955 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 451515001956 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 451515001957 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 451515001958 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 451515001959 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 451515001960 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 451515001961 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 451515001962 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 451515001963 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 451515001964 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 451515001965 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 451515001966 metal binding site [ion binding]; metal-binding site 451515001967 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 451515001968 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515001969 ABC-ATPase subunit interface; other site 451515001970 dimer interface [polypeptide binding]; other site 451515001971 putative PBP binding regions; other site 451515001972 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 451515001973 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 451515001974 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 451515001975 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 451515001976 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 451515001977 FeoA domain; Region: FeoA; pfam04023 451515001978 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 451515001979 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 451515001980 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 451515001981 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 451515001982 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 451515001983 Walker A/P-loop; other site 451515001984 ATP binding site [chemical binding]; other site 451515001985 Q-loop/lid; other site 451515001986 ABC transporter signature motif; other site 451515001987 Walker B; other site 451515001988 D-loop; other site 451515001989 H-loop/switch region; other site 451515001990 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 451515001991 ABC-2 type transporter; Region: ABC2_membrane; cl17235 451515001992 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 451515001993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 451515001994 active site 451515001995 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 451515001996 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 451515001997 active site 451515001998 nucleotide binding site [chemical binding]; other site 451515001999 HIGH motif; other site 451515002000 KMSKS motif; other site 451515002001 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 451515002002 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 451515002003 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 451515002004 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 451515002005 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 451515002006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515002007 Walker A/P-loop; other site 451515002008 ATP binding site [chemical binding]; other site 451515002009 Q-loop/lid; other site 451515002010 ABC transporter signature motif; other site 451515002011 Walker B; other site 451515002012 D-loop; other site 451515002013 H-loop/switch region; other site 451515002014 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 451515002015 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 451515002016 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 451515002017 Uncharacterized conserved protein [Function unknown]; Region: COG1284 451515002018 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 451515002019 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 451515002020 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 451515002021 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 451515002022 Walker A/P-loop; other site 451515002023 ATP binding site [chemical binding]; other site 451515002024 Q-loop/lid; other site 451515002025 ABC transporter signature motif; other site 451515002026 Walker B; other site 451515002027 D-loop; other site 451515002028 H-loop/switch region; other site 451515002029 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 451515002030 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515002031 ABC-ATPase subunit interface; other site 451515002032 dimer interface [polypeptide binding]; other site 451515002033 putative PBP binding regions; other site 451515002034 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 451515002035 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515002036 ABC-ATPase subunit interface; other site 451515002037 dimer interface [polypeptide binding]; other site 451515002038 putative PBP binding regions; other site 451515002039 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 451515002040 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 451515002041 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 451515002042 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 451515002043 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 451515002044 Uncharacterized membrane protein [Function unknown]; Region: COG3949 451515002045 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 451515002046 Na binding site [ion binding]; other site 451515002047 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 451515002048 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 451515002049 substrate binding pocket [chemical binding]; other site 451515002050 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 451515002051 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 451515002052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515002053 Coenzyme A binding pocket [chemical binding]; other site 451515002054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 451515002055 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 451515002056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 451515002057 NAD(P) binding site [chemical binding]; other site 451515002058 active site 451515002059 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 451515002060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515002061 active site 451515002062 phosphorylation site [posttranslational modification] 451515002063 intermolecular recognition site; other site 451515002064 dimerization interface [polypeptide binding]; other site 451515002065 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 451515002066 DNA binding site [nucleotide binding] 451515002067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 451515002068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 451515002069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515002070 ATP binding site [chemical binding]; other site 451515002071 Mg2+ binding site [ion binding]; other site 451515002072 G-X-G motif; other site 451515002073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 451515002074 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 451515002075 Walker A/P-loop; other site 451515002076 ATP binding site [chemical binding]; other site 451515002077 Q-loop/lid; other site 451515002078 ABC transporter signature motif; other site 451515002079 Walker B; other site 451515002080 D-loop; other site 451515002081 H-loop/switch region; other site 451515002082 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 451515002083 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 451515002084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 451515002085 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 451515002086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 451515002087 Surface antigen [General function prediction only]; Region: COG3942 451515002088 CHAP domain; Region: CHAP; pfam05257 451515002089 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 451515002090 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 451515002091 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 451515002092 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515002093 hypothetical protein; Provisional; Region: PRK12378 451515002094 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 451515002095 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 451515002096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 451515002097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 451515002098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 451515002099 dimerization interface [polypeptide binding]; other site 451515002100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515002101 sugar efflux transporter; Region: 2A0120; TIGR00899 451515002102 putative substrate translocation pore; other site 451515002103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 451515002104 Serine incorporator (Serinc); Region: Serinc; pfam03348 451515002105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515002106 Coenzyme A binding pocket [chemical binding]; other site 451515002107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 451515002108 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 451515002109 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 451515002110 hypothetical protein; Validated; Region: PRK00124 451515002111 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 451515002112 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 451515002113 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 451515002114 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 451515002115 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 451515002116 Walker A/P-loop; other site 451515002117 ATP binding site [chemical binding]; other site 451515002118 Q-loop/lid; other site 451515002119 ABC transporter signature motif; other site 451515002120 Walker B; other site 451515002121 D-loop; other site 451515002122 H-loop/switch region; other site 451515002123 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 451515002124 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 451515002125 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 451515002126 Walker A/P-loop; other site 451515002127 ATP binding site [chemical binding]; other site 451515002128 Q-loop/lid; other site 451515002129 ABC transporter signature motif; other site 451515002130 Walker B; other site 451515002131 D-loop; other site 451515002132 H-loop/switch region; other site 451515002133 Transcriptional regulators [Transcription]; Region: MarR; COG1846 451515002134 MarR family; Region: MarR; pfam01047 451515002135 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 451515002136 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 451515002137 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 451515002138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 451515002139 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 451515002140 active site 451515002141 catalytic tetrad [active] 451515002142 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 451515002143 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 451515002144 transmembrane helices; other site 451515002145 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 451515002146 DNA photolyase; Region: DNA_photolyase; pfam00875 451515002147 Predicted membrane protein [Function unknown]; Region: COG4330 451515002148 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 451515002149 trimer interface [polypeptide binding]; other site 451515002150 putative Zn binding site [ion binding]; other site 451515002151 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 451515002152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515002153 putative substrate translocation pore; other site 451515002154 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 451515002155 putative deacylase active site [active] 451515002156 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 451515002157 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 451515002158 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 451515002159 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 451515002160 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 451515002161 putative substrate binding site [chemical binding]; other site 451515002162 putative ATP binding site [chemical binding]; other site 451515002163 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 451515002164 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 451515002165 active site 451515002166 phosphorylation site [posttranslational modification] 451515002167 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 451515002168 active site 451515002169 P-loop; other site 451515002170 phosphorylation site [posttranslational modification] 451515002171 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 451515002172 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 451515002173 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 451515002174 active site 451515002175 dimer interface [polypeptide binding]; other site 451515002176 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 451515002177 Domain of unknown function DUF21; Region: DUF21; pfam01595 451515002178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 451515002179 Transporter associated domain; Region: CorC_HlyC; pfam03471 451515002180 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 451515002181 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 451515002182 active site 451515002183 catalytic tetrad [active] 451515002184 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 451515002185 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 451515002186 Ligand binding site; other site 451515002187 Putative Catalytic site; other site 451515002188 DXD motif; other site 451515002189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 451515002190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 451515002191 dimer interface [polypeptide binding]; other site 451515002192 phosphorylation site [posttranslational modification] 451515002193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515002194 ATP binding site [chemical binding]; other site 451515002195 Mg2+ binding site [ion binding]; other site 451515002196 G-X-G motif; other site 451515002197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 451515002198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515002199 active site 451515002200 phosphorylation site [posttranslational modification] 451515002201 intermolecular recognition site; other site 451515002202 dimerization interface [polypeptide binding]; other site 451515002203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 451515002204 DNA binding site [nucleotide binding] 451515002205 DoxX; Region: DoxX; pfam07681 451515002206 Electron transfer DM13; Region: DM13; pfam10517 451515002207 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 451515002208 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 451515002209 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 451515002210 active site 451515002211 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 451515002212 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 451515002213 Ligand Binding Site [chemical binding]; other site 451515002214 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 451515002215 Glutamine amidotransferase class-I; Region: GATase; pfam00117 451515002216 glutamine binding [chemical binding]; other site 451515002217 catalytic triad [active] 451515002218 aminodeoxychorismate synthase; Provisional; Region: PRK07508 451515002219 chorismate binding enzyme; Region: Chorismate_bind; cl10555 451515002220 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 451515002221 substrate-cofactor binding pocket; other site 451515002222 Aminotransferase class IV; Region: Aminotran_4; pfam01063 451515002223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515002224 catalytic residue [active] 451515002225 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 451515002226 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 451515002227 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 451515002228 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 451515002229 Sulfatase; Region: Sulfatase; pfam00884 451515002230 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 451515002231 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 451515002232 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 451515002233 ABC transporter; Region: ABC_tran_2; pfam12848 451515002234 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 451515002235 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 451515002236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515002237 ATP binding site [chemical binding]; other site 451515002238 putative Mg++ binding site [ion binding]; other site 451515002239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 451515002240 nucleotide binding region [chemical binding]; other site 451515002241 ATP-binding site [chemical binding]; other site 451515002242 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 451515002243 HRDC domain; Region: HRDC; pfam00570 451515002244 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 451515002245 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 451515002246 Walker A/P-loop; other site 451515002247 ATP binding site [chemical binding]; other site 451515002248 Q-loop/lid; other site 451515002249 ABC transporter signature motif; other site 451515002250 Walker B; other site 451515002251 D-loop; other site 451515002252 H-loop/switch region; other site 451515002253 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 451515002254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515002255 dimer interface [polypeptide binding]; other site 451515002256 conserved gate region; other site 451515002257 ABC-ATPase subunit interface; other site 451515002258 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 451515002259 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 451515002260 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 451515002261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 451515002262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515002263 homodimer interface [polypeptide binding]; other site 451515002264 catalytic residue [active] 451515002265 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 451515002266 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 451515002267 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 451515002268 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 451515002269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515002270 putative substrate translocation pore; other site 451515002271 POT family; Region: PTR2; cl17359 451515002272 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 451515002273 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 451515002274 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 451515002275 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 451515002276 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 451515002277 Class I ribonucleotide reductase; Region: RNR_I; cd01679 451515002278 active site 451515002279 dimer interface [polypeptide binding]; other site 451515002280 catalytic residues [active] 451515002281 effector binding site; other site 451515002282 R2 peptide binding site; other site 451515002283 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 451515002284 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 451515002285 dimer interface [polypeptide binding]; other site 451515002286 putative radical transfer pathway; other site 451515002287 diiron center [ion binding]; other site 451515002288 tyrosyl radical; other site 451515002289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515002290 ABC-ATPase subunit interface; other site 451515002291 dimer interface [polypeptide binding]; other site 451515002292 putative PBP binding regions; other site 451515002293 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515002294 ABC-ATPase subunit interface; other site 451515002295 dimer interface [polypeptide binding]; other site 451515002296 putative PBP binding regions; other site 451515002297 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 451515002298 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 451515002299 Walker A/P-loop; other site 451515002300 ATP binding site [chemical binding]; other site 451515002301 Q-loop/lid; other site 451515002302 ABC transporter signature motif; other site 451515002303 Walker B; other site 451515002304 D-loop; other site 451515002305 H-loop/switch region; other site 451515002306 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 451515002307 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 451515002308 putative ligand binding residues [chemical binding]; other site 451515002309 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 451515002310 FAD binding domain; Region: FAD_binding_4; pfam01565 451515002311 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 451515002312 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 451515002313 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 451515002314 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 451515002315 peptidase T; Region: peptidase-T; TIGR01882 451515002316 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 451515002317 metal binding site [ion binding]; metal-binding site 451515002318 dimer interface [polypeptide binding]; other site 451515002319 Uncharacterized conserved protein [Function unknown]; Region: COG3610 451515002320 Uncharacterized conserved protein [Function unknown]; Region: COG2966 451515002321 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 451515002322 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 451515002323 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 451515002324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 451515002325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 451515002326 metal binding site [ion binding]; metal-binding site 451515002327 active site 451515002328 I-site; other site 451515002329 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 451515002330 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 451515002331 Mg++ binding site [ion binding]; other site 451515002332 putative catalytic motif [active] 451515002333 substrate binding site [chemical binding]; other site 451515002334 Uncharacterized conserved protein [Function unknown]; Region: COG1739 451515002335 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 451515002336 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 451515002337 EDD domain protein, DegV family; Region: DegV; TIGR00762 451515002338 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 451515002339 DEAD-like helicases superfamily; Region: DEXDc; smart00487 451515002340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515002341 ATP binding site [chemical binding]; other site 451515002342 putative Mg++ binding site [ion binding]; other site 451515002343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 451515002344 nucleotide binding region [chemical binding]; other site 451515002345 ATP-binding site [chemical binding]; other site 451515002346 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 451515002347 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 451515002348 active site 451515002349 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 451515002350 30S subunit binding site; other site 451515002351 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 451515002352 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 451515002353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 451515002354 nucleotide binding region [chemical binding]; other site 451515002355 ATP-binding site [chemical binding]; other site 451515002356 SEC-C motif; Region: SEC-C; pfam02810 451515002357 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 451515002358 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 451515002359 Surface antigen [General function prediction only]; Region: COG3942 451515002360 CHAP domain; Region: CHAP; pfam05257 451515002361 HD domain; Region: HD_3; cl17350 451515002362 excinuclease ABC subunit B; Provisional; Region: PRK05298 451515002363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515002364 ATP binding site [chemical binding]; other site 451515002365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 451515002366 nucleotide binding region [chemical binding]; other site 451515002367 ATP-binding site [chemical binding]; other site 451515002368 Ultra-violet resistance protein B; Region: UvrB; pfam12344 451515002369 UvrB/uvrC motif; Region: UVR; pfam02151 451515002370 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 451515002371 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 451515002372 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 451515002373 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 451515002374 HPr kinase/phosphorylase; Provisional; Region: PRK05428 451515002375 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 451515002376 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 451515002377 Hpr binding site; other site 451515002378 active site 451515002379 homohexamer subunit interaction site [polypeptide binding]; other site 451515002380 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 451515002381 putative acyl transferase; Provisional; Region: PRK10191 451515002382 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 451515002383 trimer interface [polypeptide binding]; other site 451515002384 active site 451515002385 substrate binding site [chemical binding]; other site 451515002386 CoA binding site [chemical binding]; other site 451515002387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 451515002388 binding surface 451515002389 TPR motif; other site 451515002390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 451515002391 TPR motif; other site 451515002392 binding surface 451515002393 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 451515002394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 451515002395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515002396 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 451515002397 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 451515002398 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 451515002399 phosphate binding site [ion binding]; other site 451515002400 dimer interface [polypeptide binding]; other site 451515002401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 451515002402 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 451515002403 Clp protease; Region: CLP_protease; pfam00574 451515002404 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 451515002405 oligomer interface [polypeptide binding]; other site 451515002406 active site residues [active] 451515002407 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 451515002408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 451515002409 NAD(P) binding site [chemical binding]; other site 451515002410 active site 451515002411 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 451515002412 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 451515002413 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 451515002414 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 451515002415 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 451515002416 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 451515002417 Phosphoglycerate kinase; Region: PGK; pfam00162 451515002418 substrate binding site [chemical binding]; other site 451515002419 hinge regions; other site 451515002420 ADP binding site [chemical binding]; other site 451515002421 catalytic site [active] 451515002422 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 451515002423 triosephosphate isomerase; Provisional; Region: PRK14565 451515002424 substrate binding site [chemical binding]; other site 451515002425 dimer interface [polypeptide binding]; other site 451515002426 catalytic triad [active] 451515002427 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 451515002428 phosphoglyceromutase; Provisional; Region: PRK05434 451515002429 enolase; Provisional; Region: eno; PRK00077 451515002430 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 451515002431 dimer interface [polypeptide binding]; other site 451515002432 metal binding site [ion binding]; metal-binding site 451515002433 substrate binding pocket [chemical binding]; other site 451515002434 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 451515002435 Esterase/lipase [General function prediction only]; Region: COG1647 451515002436 Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735 451515002437 ribonuclease R; Region: RNase_R; TIGR02063 451515002438 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 451515002439 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 451515002440 RNB domain; Region: RNB; pfam00773 451515002441 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 451515002442 RNA binding site [nucleotide binding]; other site 451515002443 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 451515002444 SmpB-tmRNA interface; other site 451515002445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515002446 Coenzyme A binding pocket [chemical binding]; other site 451515002447 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515002448 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 451515002449 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 451515002450 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 451515002451 Staphylococcal nuclease homologues; Region: SNc; smart00318 451515002452 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 451515002453 Catalytic site; other site 451515002454 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 451515002455 DNA-binding site [nucleotide binding]; DNA binding site 451515002456 RNA-binding motif; other site 451515002457 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 451515002458 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 451515002459 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 451515002460 catalytic core [active] 451515002461 Lysine efflux permease [General function prediction only]; Region: COG1279 451515002462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 451515002463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 451515002464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 451515002465 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 451515002466 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 451515002467 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 451515002468 active site 451515002469 catalytic residue [active] 451515002470 dimer interface [polypeptide binding]; other site 451515002471 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 451515002472 putative FMN binding site [chemical binding]; other site 451515002473 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 451515002474 catalytic residues [active] 451515002475 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 451515002476 ArsC family; Region: ArsC; pfam03960 451515002477 putative ArsC-like catalytic residues; other site 451515002478 putative TRX-like catalytic residues [active] 451515002479 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 451515002480 lipoyl attachment site [posttranslational modification]; other site 451515002481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 451515002482 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 451515002483 putative active site [active] 451515002484 putative metal binding site [ion binding]; other site 451515002485 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 451515002486 catalytic residues [active] 451515002487 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 451515002488 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 451515002489 Walker A/P-loop; other site 451515002490 ATP binding site [chemical binding]; other site 451515002491 Q-loop/lid; other site 451515002492 ABC transporter signature motif; other site 451515002493 Walker B; other site 451515002494 D-loop; other site 451515002495 H-loop/switch region; other site 451515002496 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 451515002497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515002498 dimer interface [polypeptide binding]; other site 451515002499 conserved gate region; other site 451515002500 ABC-ATPase subunit interface; other site 451515002501 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 451515002502 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 451515002503 pathogenicity island SaPI5 451515002504 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 451515002505 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 451515002506 Int/Topo IB signature motif; other site 451515002507 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 451515002508 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515002509 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 451515002510 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515002511 Domain of unknown function (DUF955); Region: DUF955; pfam06114 451515002512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515002513 non-specific DNA binding site [nucleotide binding]; other site 451515002514 salt bridge; other site 451515002515 sequence-specific DNA binding site [nucleotide binding]; other site 451515002516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515002517 non-specific DNA binding site [nucleotide binding]; other site 451515002518 salt bridge; other site 451515002519 sequence-specific DNA binding site [nucleotide binding]; other site 451515002520 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 451515002521 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 451515002522 Uncharacterized conserved protein [Function unknown]; Region: COG4983 451515002523 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 451515002524 nucleotide binding site [chemical binding]; other site 451515002525 D5 N terminal like; Region: D5_N; smart00885 451515002526 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 451515002527 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 451515002528 Abi-like protein; Region: Abi_2; pfam07751 451515002529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 451515002530 Predicted membrane protein [Function unknown]; Region: COG2035 451515002531 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 451515002532 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 451515002533 Walker A/P-loop; other site 451515002534 ATP binding site [chemical binding]; other site 451515002535 Q-loop/lid; other site 451515002536 ABC transporter signature motif; other site 451515002537 Walker B; other site 451515002538 D-loop; other site 451515002539 H-loop/switch region; other site 451515002540 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 451515002541 FeS assembly protein SufD; Region: sufD; TIGR01981 451515002542 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 451515002543 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 451515002544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 451515002545 catalytic residue [active] 451515002546 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 451515002547 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 451515002548 trimerization site [polypeptide binding]; other site 451515002549 active site 451515002550 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 451515002551 FeS assembly protein SufB; Region: sufB; TIGR01980 451515002552 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 451515002553 Domain of unknown function DUF21; Region: DUF21; pfam01595 451515002554 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 451515002555 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 451515002556 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 451515002557 FMN binding site [chemical binding]; other site 451515002558 substrate binding site [chemical binding]; other site 451515002559 putative catalytic residue [active] 451515002560 Uncharacterized conserved protein [Function unknown]; Region: COG1801 451515002561 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 451515002562 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 451515002563 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 451515002564 active site 451515002565 metal binding site [ion binding]; metal-binding site 451515002566 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 451515002567 lipoyl synthase; Provisional; Region: PRK05481 451515002568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515002569 FeS/SAM binding site; other site 451515002570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 451515002571 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 451515002572 Uncharacterized conserved protein [Function unknown]; Region: COG2445 451515002573 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 451515002574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515002575 active site 451515002576 motif I; other site 451515002577 motif II; other site 451515002578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515002579 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 451515002580 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 451515002581 dimerization interface [polypeptide binding]; other site 451515002582 ligand binding site [chemical binding]; other site 451515002583 NADP binding site [chemical binding]; other site 451515002584 catalytic site [active] 451515002585 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 451515002586 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 451515002587 acyl-activating enzyme (AAE) consensus motif; other site 451515002588 AMP binding site [chemical binding]; other site 451515002589 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 451515002590 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 451515002591 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 451515002592 DltD N-terminal region; Region: DltD_N; pfam04915 451515002593 DltD central region; Region: DltD_M; pfam04918 451515002594 DltD C-terminal region; Region: DltD_C; pfam04914 451515002595 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 451515002596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 451515002597 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 451515002598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515002599 hypothetical protein; Provisional; Region: PRK13669 451515002600 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 451515002601 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 451515002602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515002603 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 451515002604 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 451515002605 interface (dimer of trimers) [polypeptide binding]; other site 451515002606 Substrate-binding/catalytic site; other site 451515002607 Zn-binding sites [ion binding]; other site 451515002608 Predicted permease [General function prediction only]; Region: COG2056 451515002609 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 451515002610 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 451515002611 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 451515002612 CoenzymeA binding site [chemical binding]; other site 451515002613 subunit interaction site [polypeptide binding]; other site 451515002614 PHB binding site; other site 451515002615 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 451515002616 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 451515002617 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 451515002618 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 451515002619 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 451515002620 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 451515002621 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 451515002622 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 451515002623 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 451515002624 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 451515002625 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 451515002626 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 451515002627 Kinase associated protein B; Region: KapB; pfam08810 451515002628 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 451515002629 active site 451515002630 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 451515002631 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 451515002632 RNA binding site [nucleotide binding]; other site 451515002633 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 451515002634 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 451515002635 putative active site [active] 451515002636 putative FMN binding site [chemical binding]; other site 451515002637 putative substrate binding site [chemical binding]; other site 451515002638 putative catalytic residue [active] 451515002639 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 451515002640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 451515002641 inhibitor-cofactor binding pocket; inhibition site 451515002642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515002643 catalytic residue [active] 451515002644 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 451515002645 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 451515002646 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 451515002647 NAD(P) binding site [chemical binding]; other site 451515002648 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 451515002649 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 451515002650 active site 451515002651 catalytic site [active] 451515002652 metal binding site [ion binding]; metal-binding site 451515002653 argininosuccinate lyase; Provisional; Region: PRK00855 451515002654 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 451515002655 active sites [active] 451515002656 tetramer interface [polypeptide binding]; other site 451515002657 argininosuccinate synthase; Provisional; Region: PRK13820 451515002658 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 451515002659 ANP binding site [chemical binding]; other site 451515002660 Substrate Binding Site II [chemical binding]; other site 451515002661 Substrate Binding Site I [chemical binding]; other site 451515002662 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 451515002663 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 451515002664 active site 451515002665 dimer interface [polypeptide binding]; other site 451515002666 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 451515002667 dimer interface [polypeptide binding]; other site 451515002668 active site 451515002669 Uncharacterized conserved protein [Function unknown]; Region: COG0398 451515002670 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 451515002671 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 451515002672 Catalytic site [active] 451515002673 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 451515002674 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 451515002675 Catalytic site [active] 451515002676 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 451515002677 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 451515002678 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 451515002679 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 451515002680 Part of AAA domain; Region: AAA_19; pfam13245 451515002681 Family description; Region: UvrD_C_2; pfam13538 451515002682 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 451515002683 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 451515002684 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 451515002685 hypothetical protein; Provisional; Region: PRK13673 451515002686 coenzyme A disulfide reductase; Provisional; Region: PRK13512 451515002687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 451515002688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515002689 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 451515002690 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 451515002691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515002692 active site 451515002693 motif I; other site 451515002694 motif II; other site 451515002695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515002696 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 451515002697 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 451515002698 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 451515002699 catalytic triad [active] 451515002700 catalytic triad [active] 451515002701 oxyanion hole [active] 451515002702 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 451515002703 Clp amino terminal domain; Region: Clp_N; pfam02861 451515002704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515002705 Walker A motif; other site 451515002706 ATP binding site [chemical binding]; other site 451515002707 Walker B motif; other site 451515002708 arginine finger; other site 451515002709 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 451515002710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515002711 Walker A motif; other site 451515002712 ATP binding site [chemical binding]; other site 451515002713 Walker B motif; other site 451515002714 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 451515002715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 451515002716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 451515002717 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 451515002718 dimerization interface [polypeptide binding]; other site 451515002719 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 451515002720 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 451515002721 active site 451515002722 catalytic residues [active] 451515002723 metal binding site [ion binding]; metal-binding site 451515002724 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 451515002725 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 451515002726 substrate binding site [chemical binding]; other site 451515002727 MAP domain; Region: MAP; pfam03642 451515002728 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 451515002729 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 451515002730 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 451515002731 dimer interface [polypeptide binding]; other site 451515002732 active site 451515002733 CoA binding pocket [chemical binding]; other site 451515002734 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 451515002735 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 451515002736 dimer interface [polypeptide binding]; other site 451515002737 active site 451515002738 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 451515002739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515002740 dimer interface [polypeptide binding]; other site 451515002741 conserved gate region; other site 451515002742 putative PBP binding loops; other site 451515002743 ABC-ATPase subunit interface; other site 451515002744 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 451515002745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515002746 dimer interface [polypeptide binding]; other site 451515002747 conserved gate region; other site 451515002748 putative PBP binding loops; other site 451515002749 ABC-ATPase subunit interface; other site 451515002750 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 451515002751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515002752 Walker A/P-loop; other site 451515002753 ATP binding site [chemical binding]; other site 451515002754 Q-loop/lid; other site 451515002755 ABC transporter signature motif; other site 451515002756 Walker B; other site 451515002757 D-loop; other site 451515002758 H-loop/switch region; other site 451515002759 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 451515002760 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 451515002761 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515002762 Walker A/P-loop; other site 451515002763 ATP binding site [chemical binding]; other site 451515002764 Q-loop/lid; other site 451515002765 ABC transporter signature motif; other site 451515002766 Walker B; other site 451515002767 D-loop; other site 451515002768 H-loop/switch region; other site 451515002769 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 451515002770 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 451515002771 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 451515002772 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 451515002773 peptide binding site [polypeptide binding]; other site 451515002774 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 451515002775 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 451515002776 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 451515002777 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515002778 Walker A/P-loop; other site 451515002779 ATP binding site [chemical binding]; other site 451515002780 Q-loop/lid; other site 451515002781 ABC transporter signature motif; other site 451515002782 Walker B; other site 451515002783 D-loop; other site 451515002784 H-loop/switch region; other site 451515002785 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 451515002786 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 451515002787 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515002788 Walker A/P-loop; other site 451515002789 ATP binding site [chemical binding]; other site 451515002790 Q-loop/lid; other site 451515002791 ABC transporter signature motif; other site 451515002792 Walker B; other site 451515002793 D-loop; other site 451515002794 H-loop/switch region; other site 451515002795 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 451515002796 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 451515002797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515002798 dimer interface [polypeptide binding]; other site 451515002799 conserved gate region; other site 451515002800 putative PBP binding loops; other site 451515002801 ABC-ATPase subunit interface; other site 451515002802 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 451515002803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515002804 dimer interface [polypeptide binding]; other site 451515002805 conserved gate region; other site 451515002806 putative PBP binding loops; other site 451515002807 ABC-ATPase subunit interface; other site 451515002808 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 451515002809 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 451515002810 active site 451515002811 HIGH motif; other site 451515002812 dimer interface [polypeptide binding]; other site 451515002813 KMSKS motif; other site 451515002814 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 451515002815 ArsC family; Region: ArsC; pfam03960 451515002816 putative catalytic residues [active] 451515002817 thiol/disulfide switch; other site 451515002818 adaptor protein; Provisional; Region: PRK02315 451515002819 Competence protein CoiA-like family; Region: CoiA; cl11541 451515002820 Competence protein CoiA-like family; Region: CoiA; cl11541 451515002821 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 451515002822 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 451515002823 active site 451515002824 Zn binding site [ion binding]; other site 451515002825 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 451515002826 Thioredoxin; Region: Thioredoxin_5; pfam13743 451515002827 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 451515002828 apolar tunnel; other site 451515002829 heme binding site [chemical binding]; other site 451515002830 dimerization interface [polypeptide binding]; other site 451515002831 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 451515002832 putative active site [active] 451515002833 putative metal binding residues [ion binding]; other site 451515002834 signature motif; other site 451515002835 putative triphosphate binding site [ion binding]; other site 451515002836 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 451515002837 synthetase active site [active] 451515002838 NTP binding site [chemical binding]; other site 451515002839 metal binding site [ion binding]; metal-binding site 451515002840 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 451515002841 ATP-NAD kinase; Region: NAD_kinase; pfam01513 451515002842 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 451515002843 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 451515002844 active site 451515002845 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 451515002846 MgtE intracellular N domain; Region: MgtE_N; smart00924 451515002847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 451515002848 Divalent cation transporter; Region: MgtE; pfam01769 451515002849 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 451515002850 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 451515002851 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 451515002852 TrkA-N domain; Region: TrkA_N; pfam02254 451515002853 TrkA-C domain; Region: TrkA_C; pfam02080 451515002854 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 451515002855 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 451515002856 NAD binding site [chemical binding]; other site 451515002857 homotetramer interface [polypeptide binding]; other site 451515002858 homodimer interface [polypeptide binding]; other site 451515002859 substrate binding site [chemical binding]; other site 451515002860 active site 451515002861 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 451515002862 Domain of unknown function DUF20; Region: UPF0118; pfam01594 451515002863 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 451515002864 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 451515002865 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 451515002866 Putative esterase; Region: Esterase; pfam00756 451515002867 hypothetical protein; Provisional; Region: PRK13679 451515002868 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 451515002869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 451515002870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515002871 putative substrate translocation pore; other site 451515002872 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 451515002873 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 451515002874 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 451515002875 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 451515002876 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 451515002877 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 451515002878 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 451515002879 YueH-like protein; Region: YueH; pfam14166 451515002880 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 451515002881 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 451515002882 G1 box; other site 451515002883 putative GEF interaction site [polypeptide binding]; other site 451515002884 GTP/Mg2+ binding site [chemical binding]; other site 451515002885 Switch I region; other site 451515002886 G2 box; other site 451515002887 G3 box; other site 451515002888 Switch II region; other site 451515002889 G4 box; other site 451515002890 G5 box; other site 451515002891 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 451515002892 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 451515002893 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 451515002894 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 451515002895 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 451515002896 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 451515002897 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 451515002898 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 451515002899 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 451515002900 active site 451515002901 metal binding site [ion binding]; metal-binding site 451515002902 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 451515002903 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 451515002904 IDEAL domain; Region: IDEAL; pfam08858 451515002905 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 451515002906 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 451515002907 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 451515002908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 451515002909 CAAX protease self-immunity; Region: Abi; pfam02517 451515002910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 451515002911 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 451515002912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 451515002913 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 451515002914 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 451515002915 Walker A/P-loop; other site 451515002916 ATP binding site [chemical binding]; other site 451515002917 Q-loop/lid; other site 451515002918 ABC transporter signature motif; other site 451515002919 Walker B; other site 451515002920 D-loop; other site 451515002921 H-loop/switch region; other site 451515002922 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 451515002923 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 451515002924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 451515002925 Predicted membrane protein [Function unknown]; Region: COG2259 451515002926 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 451515002927 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 451515002928 siderophore binding site; other site 451515002929 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 451515002930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515002931 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 451515002932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 451515002933 Coenzyme A binding pocket [chemical binding]; other site 451515002934 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 451515002935 UbiA prenyltransferase family; Region: UbiA; pfam01040 451515002936 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 451515002937 isochorismate synthases; Region: isochor_syn; TIGR00543 451515002938 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 451515002939 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 451515002940 dimer interface [polypeptide binding]; other site 451515002941 tetramer interface [polypeptide binding]; other site 451515002942 PYR/PP interface [polypeptide binding]; other site 451515002943 TPP binding site [chemical binding]; other site 451515002944 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 451515002945 TPP-binding site; other site 451515002946 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 451515002947 PGAP1-like protein; Region: PGAP1; pfam07819 451515002948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 451515002949 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 451515002950 substrate binding site [chemical binding]; other site 451515002951 oxyanion hole (OAH) forming residues; other site 451515002952 trimer interface [polypeptide binding]; other site 451515002953 Staphostatin B; Region: Staphostatin_B; pfam09023 451515002954 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 451515002955 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 451515002956 aminotransferase A; Validated; Region: PRK07683 451515002957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 451515002958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515002959 homodimer interface [polypeptide binding]; other site 451515002960 catalytic residue [active] 451515002961 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 451515002962 Acyltransferase family; Region: Acyl_transf_3; pfam01757 451515002963 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 451515002964 MarR family; Region: MarR; pfam01047 451515002965 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 451515002966 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 451515002967 amidase catalytic site [active] 451515002968 Zn binding residues [ion binding]; other site 451515002969 substrate binding site [chemical binding]; other site 451515002970 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 451515002971 Lysozyme subfamily 2; Region: LYZ2; smart00047 451515002972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515002973 Coenzyme A binding pocket [chemical binding]; other site 451515002974 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 451515002975 Transcriptional regulator [Transcription]; Region: LytR; COG1316 451515002976 Beta-lactamase; Region: Beta-lactamase; pfam00144 451515002977 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 451515002978 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 451515002979 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 451515002980 Subunit I/III interface [polypeptide binding]; other site 451515002981 Subunit III/IV interface [polypeptide binding]; other site 451515002982 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 451515002983 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 451515002984 D-pathway; other site 451515002985 Putative ubiquinol binding site [chemical binding]; other site 451515002986 Low-spin heme (heme b) binding site [chemical binding]; other site 451515002987 Putative water exit pathway; other site 451515002988 Binuclear center (heme o3/CuB) [ion binding]; other site 451515002989 K-pathway; other site 451515002990 Putative proton exit pathway; other site 451515002991 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 451515002992 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 451515002993 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 451515002994 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 451515002995 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 451515002996 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 451515002997 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 451515002998 homodimer interface [polypeptide binding]; other site 451515002999 NADP binding site [chemical binding]; other site 451515003000 substrate binding site [chemical binding]; other site 451515003001 AIR carboxylase; Region: AIRC; cl00310 451515003002 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 451515003003 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 451515003004 NAD binding site [chemical binding]; other site 451515003005 ATP-grasp domain; Region: ATP-grasp; pfam02222 451515003006 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 451515003007 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 451515003008 ATP binding site [chemical binding]; other site 451515003009 active site 451515003010 substrate binding site [chemical binding]; other site 451515003011 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 451515003012 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 451515003013 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 451515003014 putative active site [active] 451515003015 catalytic triad [active] 451515003016 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 451515003017 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 451515003018 dimerization interface [polypeptide binding]; other site 451515003019 ATP binding site [chemical binding]; other site 451515003020 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 451515003021 dimerization interface [polypeptide binding]; other site 451515003022 ATP binding site [chemical binding]; other site 451515003023 amidophosphoribosyltransferase; Provisional; Region: PRK07272 451515003024 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 451515003025 active site 451515003026 tetramer interface [polypeptide binding]; other site 451515003027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 451515003028 active site 451515003029 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 451515003030 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 451515003031 dimerization interface [polypeptide binding]; other site 451515003032 putative ATP binding site [chemical binding]; other site 451515003033 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 451515003034 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 451515003035 active site 451515003036 substrate binding site [chemical binding]; other site 451515003037 cosubstrate binding site; other site 451515003038 catalytic site [active] 451515003039 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 451515003040 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 451515003041 purine monophosphate binding site [chemical binding]; other site 451515003042 dimer interface [polypeptide binding]; other site 451515003043 putative catalytic residues [active] 451515003044 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 451515003045 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 451515003046 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 451515003047 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 451515003048 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 451515003049 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 451515003050 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 451515003051 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 451515003052 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 451515003053 Walker A/P-loop; other site 451515003054 ATP binding site [chemical binding]; other site 451515003055 Q-loop/lid; other site 451515003056 ABC transporter signature motif; other site 451515003057 Walker B; other site 451515003058 D-loop; other site 451515003059 H-loop/switch region; other site 451515003060 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 451515003061 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 451515003062 Walker A/P-loop; other site 451515003063 ATP binding site [chemical binding]; other site 451515003064 Q-loop/lid; other site 451515003065 ABC transporter signature motif; other site 451515003066 Walker B; other site 451515003067 D-loop; other site 451515003068 H-loop/switch region; other site 451515003069 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 451515003070 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 451515003071 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 451515003072 putative RNA binding site [nucleotide binding]; other site 451515003073 Methyltransferase domain; Region: Methyltransf_26; pfam13659 451515003074 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 451515003075 dimerization domain swap beta strand [polypeptide binding]; other site 451515003076 regulatory protein interface [polypeptide binding]; other site 451515003077 active site 451515003078 regulatory phosphorylation site [posttranslational modification]; other site 451515003079 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 451515003080 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 451515003081 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 451515003082 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 451515003083 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 451515003084 catalytic residues [active] 451515003085 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 451515003086 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 451515003087 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 451515003088 TrkA-N domain; Region: TrkA_N; pfam02254 451515003089 TrkA-C domain; Region: TrkA_C; pfam02080 451515003090 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 451515003091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 451515003092 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 451515003093 hypothetical protein; Provisional; Region: PRK13667 451515003094 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 451515003095 active site 451515003096 catalytic residues [active] 451515003097 metal binding site [ion binding]; metal-binding site 451515003098 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 451515003099 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 451515003100 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 451515003101 TPP-binding site [chemical binding]; other site 451515003102 tetramer interface [polypeptide binding]; other site 451515003103 heterodimer interface [polypeptide binding]; other site 451515003104 phosphorylation loop region [posttranslational modification] 451515003105 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 451515003106 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 451515003107 alpha subunit interface [polypeptide binding]; other site 451515003108 TPP binding site [chemical binding]; other site 451515003109 heterodimer interface [polypeptide binding]; other site 451515003110 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 451515003111 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 451515003112 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 451515003113 E3 interaction surface; other site 451515003114 lipoyl attachment site [posttranslational modification]; other site 451515003115 e3 binding domain; Region: E3_binding; pfam02817 451515003116 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 451515003117 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 451515003118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 451515003119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515003120 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 451515003121 hypothetical protein; Provisional; Region: PRK04387 451515003122 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 451515003123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515003124 non-specific DNA binding site [nucleotide binding]; other site 451515003125 salt bridge; other site 451515003126 sequence-specific DNA binding site [nucleotide binding]; other site 451515003127 Cupin domain; Region: Cupin_2; pfam07883 451515003128 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 451515003129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515003130 Walker A/P-loop; other site 451515003131 ATP binding site [chemical binding]; other site 451515003132 Q-loop/lid; other site 451515003133 ABC transporter signature motif; other site 451515003134 Walker B; other site 451515003135 D-loop; other site 451515003136 H-loop/switch region; other site 451515003137 TOBE domain; Region: TOBE_2; pfam08402 451515003138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515003139 putative PBP binding loops; other site 451515003140 dimer interface [polypeptide binding]; other site 451515003141 ABC-ATPase subunit interface; other site 451515003142 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 451515003143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515003144 dimer interface [polypeptide binding]; other site 451515003145 conserved gate region; other site 451515003146 putative PBP binding loops; other site 451515003147 ABC-ATPase subunit interface; other site 451515003148 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 451515003149 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 451515003150 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 451515003151 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 451515003152 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 451515003153 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 451515003154 manganese transport protein MntH; Reviewed; Region: PRK00701 451515003155 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 451515003156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 451515003157 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 451515003158 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 451515003159 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 451515003160 active site 451515003161 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 451515003162 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 451515003163 G1 box; other site 451515003164 putative GEF interaction site [polypeptide binding]; other site 451515003165 GTP/Mg2+ binding site [chemical binding]; other site 451515003166 Switch I region; other site 451515003167 G2 box; other site 451515003168 G3 box; other site 451515003169 Switch II region; other site 451515003170 G4 box; other site 451515003171 G5 box; other site 451515003172 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 451515003173 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 451515003174 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 451515003175 hypothetical protein; Provisional; Region: PRK13666 451515003176 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 451515003177 pyruvate carboxylase; Reviewed; Region: PRK12999 451515003178 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 451515003179 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 451515003180 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 451515003181 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 451515003182 active site 451515003183 catalytic residues [active] 451515003184 metal binding site [ion binding]; metal-binding site 451515003185 homodimer binding site [polypeptide binding]; other site 451515003186 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 451515003187 carboxyltransferase (CT) interaction site; other site 451515003188 biotinylation site [posttranslational modification]; other site 451515003189 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 451515003190 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 451515003191 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 451515003192 UbiA prenyltransferase family; Region: UbiA; pfam01040 451515003193 Predicted membrane protein [Function unknown]; Region: COG2322 451515003194 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 451515003195 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 451515003196 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 451515003197 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 451515003198 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 451515003199 putative active site [active] 451515003200 catalytic site [active] 451515003201 putative metal binding site [ion binding]; other site 451515003202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 451515003203 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 451515003204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515003205 S-adenosylmethionine binding site [chemical binding]; other site 451515003206 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 451515003207 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 451515003208 active site 451515003209 (T/H)XGH motif; other site 451515003210 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 451515003211 hypothetical protein; Provisional; Region: PRK13670 451515003212 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 451515003213 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 451515003214 heme uptake protein IsdB; Region: IsdB; TIGR03657 451515003215 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515003216 NEAr Transporter domain; Region: NEAT; smart00725 451515003217 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 451515003218 heme-binding site [chemical binding]; other site 451515003219 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 451515003220 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 451515003221 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 451515003222 heme-binding site [chemical binding]; other site 451515003223 heme uptake protein IsdC; Region: IsdC; TIGR03656 451515003224 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 451515003225 heme-binding site [chemical binding]; other site 451515003226 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 451515003227 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 451515003228 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 451515003229 intersubunit interface [polypeptide binding]; other site 451515003230 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 451515003231 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515003232 ABC-ATPase subunit interface; other site 451515003233 dimer interface [polypeptide binding]; other site 451515003234 putative PBP binding regions; other site 451515003235 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 451515003236 active site 451515003237 catalytic site [active] 451515003238 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 451515003239 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 451515003240 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 451515003241 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 451515003242 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 451515003243 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 451515003244 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 451515003245 dimer interface [polypeptide binding]; other site 451515003246 motif 1; other site 451515003247 active site 451515003248 motif 2; other site 451515003249 motif 3; other site 451515003250 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 451515003251 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 451515003252 putative tRNA-binding site [nucleotide binding]; other site 451515003253 B3/4 domain; Region: B3_4; pfam03483 451515003254 tRNA synthetase B5 domain; Region: B5; smart00874 451515003255 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 451515003256 dimer interface [polypeptide binding]; other site 451515003257 motif 1; other site 451515003258 motif 3; other site 451515003259 motif 2; other site 451515003260 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 451515003261 ribonuclease HIII; Provisional; Region: PRK00996 451515003262 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 451515003263 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 451515003264 RNA/DNA hybrid binding site [nucleotide binding]; other site 451515003265 active site 451515003266 Cell division protein ZapA; Region: ZapA; cl01146 451515003267 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 451515003268 Colicin V production protein; Region: Colicin_V; pfam02674 451515003269 hypothetical protein; Provisional; Region: PRK08609 451515003270 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 451515003271 active site 451515003272 primer binding site [nucleotide binding]; other site 451515003273 NTP binding site [chemical binding]; other site 451515003274 metal binding triad [ion binding]; metal-binding site 451515003275 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 451515003276 active site 451515003277 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 451515003278 MutS domain III; Region: MutS_III; pfam05192 451515003279 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 451515003280 Walker A/P-loop; other site 451515003281 ATP binding site [chemical binding]; other site 451515003282 Q-loop/lid; other site 451515003283 ABC transporter signature motif; other site 451515003284 Walker B; other site 451515003285 D-loop; other site 451515003286 H-loop/switch region; other site 451515003287 Smr domain; Region: Smr; pfam01713 451515003288 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 451515003289 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 451515003290 catalytic residues [active] 451515003291 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 451515003292 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 451515003293 GIY-YIG motif/motif A; other site 451515003294 active site 451515003295 catalytic site [active] 451515003296 putative DNA binding site [nucleotide binding]; other site 451515003297 metal binding site [ion binding]; metal-binding site 451515003298 UvrB/uvrC motif; Region: UVR; pfam02151 451515003299 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 451515003300 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 451515003301 putative Iron-sulfur protein interface [polypeptide binding]; other site 451515003302 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 451515003303 proximal heme binding site [chemical binding]; other site 451515003304 distal heme binding site [chemical binding]; other site 451515003305 putative dimer interface [polypeptide binding]; other site 451515003306 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 451515003307 L-aspartate oxidase; Provisional; Region: PRK06175 451515003308 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 451515003309 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 451515003310 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 451515003311 glutamate racemase; Provisional; Region: PRK00865 451515003312 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 451515003313 active site 451515003314 dimerization interface [polypeptide binding]; other site 451515003315 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 451515003316 active site 451515003317 metal binding site [ion binding]; metal-binding site 451515003318 homotetramer interface [polypeptide binding]; other site 451515003319 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 451515003320 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 451515003321 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 451515003322 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 451515003323 beta-channel forming cytolysin; Region: hlyII; TIGR01002 451515003324 superantigen-like protein; Reviewed; Region: PRK13350 451515003325 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515003326 superantigen-like protein; Reviewed; Region: PRK13349 451515003327 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515003328 superantigen-like protein; Reviewed; Region: PRK13043 451515003329 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515003330 ornithine carbamoyltransferase; Provisional; Region: PRK04284 451515003331 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 451515003332 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 451515003333 carbamate kinase; Reviewed; Region: PRK12686 451515003334 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 451515003335 putative substrate binding site [chemical binding]; other site 451515003336 nucleotide binding site [chemical binding]; other site 451515003337 nucleotide binding site [chemical binding]; other site 451515003338 homodimer interface [polypeptide binding]; other site 451515003339 Predicted membrane protein [Function unknown]; Region: COG1288 451515003340 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 451515003341 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 451515003342 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 451515003343 gating phenylalanine in ion channel; other site 451515003344 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 451515003345 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 451515003346 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 451515003347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515003348 motif II; other site 451515003349 hypothetical protein; Provisional; Region: PRK13688 451515003350 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 451515003351 Coenzyme A binding pocket [chemical binding]; other site 451515003352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 451515003353 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 451515003354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 451515003355 MraZ protein; Region: MraZ; pfam02381 451515003356 MraZ protein; Region: MraZ; pfam02381 451515003357 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 451515003358 MraW methylase family; Region: Methyltransf_5; pfam01795 451515003359 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 451515003360 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 451515003361 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 451515003362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 451515003363 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 451515003364 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 451515003365 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 451515003366 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 451515003367 Mg++ binding site [ion binding]; other site 451515003368 putative catalytic motif [active] 451515003369 putative substrate binding site [chemical binding]; other site 451515003370 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 451515003371 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 451515003372 NAD binding site [chemical binding]; other site 451515003373 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 451515003374 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 451515003375 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 451515003376 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 451515003377 Cell division protein FtsQ; Region: FtsQ; pfam03799 451515003378 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 451515003379 Cell division protein FtsA; Region: FtsA; smart00842 451515003380 Cell division protein FtsA; Region: FtsA; pfam14450 451515003381 cell division protein FtsZ; Validated; Region: PRK09330 451515003382 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 451515003383 nucleotide binding site [chemical binding]; other site 451515003384 SulA interaction site; other site 451515003385 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 451515003386 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 451515003387 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 451515003388 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 451515003389 catalytic residue [active] 451515003390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 451515003391 YGGT family; Region: YGGT; pfam02325 451515003392 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 451515003393 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 451515003394 RNA binding surface [nucleotide binding]; other site 451515003395 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 451515003396 DivIVA domain; Region: DivI1A_domain; TIGR03544 451515003397 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 451515003398 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 451515003399 HIGH motif; other site 451515003400 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 451515003401 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 451515003402 active site 451515003403 KMSKS motif; other site 451515003404 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 451515003405 tRNA binding surface [nucleotide binding]; other site 451515003406 anticodon binding site; other site 451515003407 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 451515003408 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 451515003409 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 451515003410 active site 451515003411 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 451515003412 lipoprotein signal peptidase; Provisional; Region: PRK14787 451515003413 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 451515003414 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 451515003415 RNA binding surface [nucleotide binding]; other site 451515003416 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 451515003417 active site 451515003418 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 451515003419 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 451515003420 uracil transporter; Provisional; Region: PRK10720 451515003421 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 451515003422 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 451515003423 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 451515003424 dihydroorotase; Validated; Region: pyrC; PRK09357 451515003425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 451515003426 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 451515003427 active site 451515003428 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 451515003429 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 451515003430 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 451515003431 catalytic site [active] 451515003432 subunit interface [polypeptide binding]; other site 451515003433 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 451515003434 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 451515003435 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 451515003436 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 451515003437 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 451515003438 ATP-grasp domain; Region: ATP-grasp_4; cl17255 451515003439 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 451515003440 IMP binding site; other site 451515003441 dimer interface [polypeptide binding]; other site 451515003442 interdomain contacts; other site 451515003443 partial ornithine binding site; other site 451515003444 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 451515003445 active site 451515003446 dimer interface [polypeptide binding]; other site 451515003447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 451515003448 active site 451515003449 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 451515003450 dimer interface [polypeptide binding]; other site 451515003451 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 451515003452 Domain of unknown function (DUF814); Region: DUF814; pfam05670 451515003453 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 451515003454 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 451515003455 catalytic site [active] 451515003456 G-X2-G-X-G-K; other site 451515003457 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 451515003458 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 451515003459 Flavoprotein; Region: Flavoprotein; pfam02441 451515003460 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 451515003461 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 451515003462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515003463 ATP binding site [chemical binding]; other site 451515003464 putative Mg++ binding site [ion binding]; other site 451515003465 helicase superfamily c-terminal domain; Region: HELICc; smart00490 451515003466 nucleotide binding region [chemical binding]; other site 451515003467 ATP-binding site [chemical binding]; other site 451515003468 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 451515003469 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 451515003470 active site 451515003471 catalytic residues [active] 451515003472 metal binding site [ion binding]; metal-binding site 451515003473 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 451515003474 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 451515003475 putative active site [active] 451515003476 substrate binding site [chemical binding]; other site 451515003477 putative cosubstrate binding site; other site 451515003478 catalytic site [active] 451515003479 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 451515003480 substrate binding site [chemical binding]; other site 451515003481 16S rRNA methyltransferase B; Provisional; Region: PRK14902 451515003482 NusB family; Region: NusB; pfam01029 451515003483 putative RNA binding site [nucleotide binding]; other site 451515003484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515003485 S-adenosylmethionine binding site [chemical binding]; other site 451515003486 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 451515003487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515003488 FeS/SAM binding site; other site 451515003489 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 451515003490 Protein phosphatase 2C; Region: PP2C; pfam00481 451515003491 active site 451515003492 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 451515003493 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 451515003494 active site 451515003495 ATP binding site [chemical binding]; other site 451515003496 substrate binding site [chemical binding]; other site 451515003497 activation loop (A-loop); other site 451515003498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 451515003499 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 451515003500 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 451515003501 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 451515003502 Predicted GTPases [General function prediction only]; Region: COG1162 451515003503 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 451515003504 RNA binding site [nucleotide binding]; other site 451515003505 homodimer interface [polypeptide binding]; other site 451515003506 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 451515003507 GTPase/Zn-binding domain interface [polypeptide binding]; other site 451515003508 GTP/Mg2+ binding site [chemical binding]; other site 451515003509 G4 box; other site 451515003510 G5 box; other site 451515003511 G1 box; other site 451515003512 Switch I region; other site 451515003513 G2 box; other site 451515003514 G3 box; other site 451515003515 Switch II region; other site 451515003516 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 451515003517 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 451515003518 substrate binding site [chemical binding]; other site 451515003519 hexamer interface [polypeptide binding]; other site 451515003520 metal binding site [ion binding]; metal-binding site 451515003521 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 451515003522 Thiamine pyrophosphokinase; Region: TPK; cd07995 451515003523 active site 451515003524 dimerization interface [polypeptide binding]; other site 451515003525 thiamine binding site [chemical binding]; other site 451515003526 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 451515003527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 451515003528 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 451515003529 DAK2 domain; Region: Dak2; pfam02734 451515003530 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 451515003531 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 451515003532 generic binding surface II; other site 451515003533 ssDNA binding site; other site 451515003534 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515003535 ATP binding site [chemical binding]; other site 451515003536 putative Mg++ binding site [ion binding]; other site 451515003537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 451515003538 nucleotide binding region [chemical binding]; other site 451515003539 ATP-binding site [chemical binding]; other site 451515003540 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 451515003541 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 451515003542 active site 2 [active] 451515003543 active site 1 [active] 451515003544 putative phosphate acyltransferase; Provisional; Region: PRK05331 451515003545 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 451515003546 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 451515003547 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 451515003548 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 451515003549 NAD(P) binding site [chemical binding]; other site 451515003550 homotetramer interface [polypeptide binding]; other site 451515003551 homodimer interface [polypeptide binding]; other site 451515003552 active site 451515003553 acyl carrier protein; Provisional; Region: acpP; PRK00982 451515003554 ribonuclease III; Reviewed; Region: rnc; PRK00102 451515003555 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 451515003556 dimerization interface [polypeptide binding]; other site 451515003557 active site 451515003558 metal binding site [ion binding]; metal-binding site 451515003559 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 451515003560 dsRNA binding site [nucleotide binding]; other site 451515003561 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 451515003562 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 451515003563 Walker A/P-loop; other site 451515003564 ATP binding site [chemical binding]; other site 451515003565 Q-loop/lid; other site 451515003566 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 451515003567 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 451515003568 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 451515003569 ABC transporter signature motif; other site 451515003570 Walker B; other site 451515003571 D-loop; other site 451515003572 H-loop/switch region; other site 451515003573 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 451515003574 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 451515003575 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 451515003576 P loop; other site 451515003577 GTP binding site [chemical binding]; other site 451515003578 putative DNA-binding protein; Validated; Region: PRK00118 451515003579 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 451515003580 signal recognition particle protein; Provisional; Region: PRK10867 451515003581 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 451515003582 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 451515003583 P loop; other site 451515003584 GTP binding site [chemical binding]; other site 451515003585 Signal peptide binding domain; Region: SRP_SPB; pfam02978 451515003586 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 451515003587 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 451515003588 RimM N-terminal domain; Region: RimM; pfam01782 451515003589 PRC-barrel domain; Region: PRC; pfam05239 451515003590 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 451515003591 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 451515003592 Predicted membrane protein [Function unknown]; Region: COG4485 451515003593 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 451515003594 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 451515003595 GTP/Mg2+ binding site [chemical binding]; other site 451515003596 G4 box; other site 451515003597 G5 box; other site 451515003598 G1 box; other site 451515003599 Switch I region; other site 451515003600 G2 box; other site 451515003601 G3 box; other site 451515003602 Switch II region; other site 451515003603 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 451515003604 RNA/DNA hybrid binding site [nucleotide binding]; other site 451515003605 active site 451515003606 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 451515003607 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 451515003608 CoA-ligase; Region: Ligase_CoA; pfam00549 451515003609 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 451515003610 CoA binding domain; Region: CoA_binding; pfam02629 451515003611 CoA-ligase; Region: Ligase_CoA; pfam00549 451515003612 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 451515003613 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 451515003614 CHAP domain; Region: CHAP; pfam05257 451515003615 FemAB family; Region: FemAB; pfam02388 451515003616 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 451515003617 DNA protecting protein DprA; Region: dprA; TIGR00732 451515003618 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 451515003619 DNA topoisomerase I; Validated; Region: PRK05582 451515003620 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 451515003621 active site 451515003622 interdomain interaction site; other site 451515003623 putative metal-binding site [ion binding]; other site 451515003624 nucleotide binding site [chemical binding]; other site 451515003625 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 451515003626 domain I; other site 451515003627 DNA binding groove [nucleotide binding] 451515003628 phosphate binding site [ion binding]; other site 451515003629 domain II; other site 451515003630 domain III; other site 451515003631 nucleotide binding site [chemical binding]; other site 451515003632 catalytic site [active] 451515003633 domain IV; other site 451515003634 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 451515003635 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 451515003636 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 451515003637 Glucose inhibited division protein A; Region: GIDA; pfam01134 451515003638 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 451515003639 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 451515003640 active site 451515003641 DNA binding site [nucleotide binding] 451515003642 Int/Topo IB signature motif; other site 451515003643 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 451515003644 active site 451515003645 HslU subunit interaction site [polypeptide binding]; other site 451515003646 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 451515003647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515003648 Walker A motif; other site 451515003649 ATP binding site [chemical binding]; other site 451515003650 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 451515003651 Walker B motif; other site 451515003652 arginine finger; other site 451515003653 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 451515003654 transcriptional repressor CodY; Validated; Region: PRK04158 451515003655 CodY GAF-like domain; Region: CodY; pfam06018 451515003656 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 451515003657 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 451515003658 rRNA interaction site [nucleotide binding]; other site 451515003659 S8 interaction site; other site 451515003660 putative laminin-1 binding site; other site 451515003661 elongation factor Ts; Provisional; Region: tsf; PRK09377 451515003662 UBA/TS-N domain; Region: UBA; pfam00627 451515003663 Elongation factor TS; Region: EF_TS; pfam00889 451515003664 Elongation factor TS; Region: EF_TS; pfam00889 451515003665 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 451515003666 putative nucleotide binding site [chemical binding]; other site 451515003667 uridine monophosphate binding site [chemical binding]; other site 451515003668 homohexameric interface [polypeptide binding]; other site 451515003669 ribosome recycling factor; Reviewed; Region: frr; PRK00083 451515003670 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 451515003671 hinge region; other site 451515003672 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 451515003673 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 451515003674 catalytic residue [active] 451515003675 putative FPP diphosphate binding site; other site 451515003676 putative FPP binding hydrophobic cleft; other site 451515003677 dimer interface [polypeptide binding]; other site 451515003678 putative IPP diphosphate binding site; other site 451515003679 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 451515003680 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 451515003681 RIP metalloprotease RseP; Region: TIGR00054 451515003682 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 451515003683 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 451515003684 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 451515003685 protein binding site [polypeptide binding]; other site 451515003686 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 451515003687 putative substrate binding region [chemical binding]; other site 451515003688 prolyl-tRNA synthetase; Provisional; Region: PRK09194 451515003689 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 451515003690 dimer interface [polypeptide binding]; other site 451515003691 motif 1; other site 451515003692 active site 451515003693 motif 2; other site 451515003694 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 451515003695 putative deacylase active site [active] 451515003696 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 451515003697 active site 451515003698 motif 3; other site 451515003699 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 451515003700 anticodon binding site; other site 451515003701 DNA polymerase III PolC; Validated; Region: polC; PRK00448 451515003702 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 451515003703 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 451515003704 generic binding surface II; other site 451515003705 generic binding surface I; other site 451515003706 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 451515003707 active site 451515003708 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 451515003709 active site 451515003710 catalytic site [active] 451515003711 substrate binding site [chemical binding]; other site 451515003712 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 451515003713 ribosome maturation protein RimP; Reviewed; Region: PRK00092 451515003714 Sm and related proteins; Region: Sm_like; cl00259 451515003715 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 451515003716 putative oligomer interface [polypeptide binding]; other site 451515003717 putative RNA binding site [nucleotide binding]; other site 451515003718 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 451515003719 NusA N-terminal domain; Region: NusA_N; pfam08529 451515003720 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 451515003721 RNA binding site [nucleotide binding]; other site 451515003722 homodimer interface [polypeptide binding]; other site 451515003723 NusA-like KH domain; Region: KH_5; pfam13184 451515003724 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 451515003725 G-X-X-G motif; other site 451515003726 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 451515003727 putative RNA binding cleft [nucleotide binding]; other site 451515003728 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 451515003729 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 451515003730 translation initiation factor IF-2; Region: IF-2; TIGR00487 451515003731 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 451515003732 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 451515003733 G1 box; other site 451515003734 putative GEF interaction site [polypeptide binding]; other site 451515003735 GTP/Mg2+ binding site [chemical binding]; other site 451515003736 Switch I region; other site 451515003737 G2 box; other site 451515003738 G3 box; other site 451515003739 Switch II region; other site 451515003740 G4 box; other site 451515003741 G5 box; other site 451515003742 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 451515003743 Translation-initiation factor 2; Region: IF-2; pfam11987 451515003744 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 451515003745 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 451515003746 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 451515003747 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 451515003748 RNA binding site [nucleotide binding]; other site 451515003749 active site 451515003750 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 451515003751 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 451515003752 active site 451515003753 Riboflavin kinase; Region: Flavokinase; smart00904 451515003754 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 451515003755 16S/18S rRNA binding site [nucleotide binding]; other site 451515003756 S13e-L30e interaction site [polypeptide binding]; other site 451515003757 25S rRNA binding site [nucleotide binding]; other site 451515003758 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 451515003759 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 451515003760 RNase E interface [polypeptide binding]; other site 451515003761 trimer interface [polypeptide binding]; other site 451515003762 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 451515003763 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 451515003764 RNase E interface [polypeptide binding]; other site 451515003765 trimer interface [polypeptide binding]; other site 451515003766 active site 451515003767 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 451515003768 putative nucleic acid binding region [nucleotide binding]; other site 451515003769 G-X-X-G motif; other site 451515003770 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 451515003771 RNA binding site [nucleotide binding]; other site 451515003772 domain interface; other site 451515003773 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 451515003774 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 451515003775 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 451515003776 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 451515003777 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 451515003778 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 451515003779 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 451515003780 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 451515003781 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 451515003782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 451515003783 DNA-binding site [nucleotide binding]; DNA binding site 451515003784 UTRA domain; Region: UTRA; pfam07702 451515003785 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 451515003786 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 451515003787 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 451515003788 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 451515003789 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 451515003790 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 451515003791 classical (c) SDRs; Region: SDR_c; cd05233 451515003792 NAD(P) binding site [chemical binding]; other site 451515003793 active site 451515003794 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 451515003795 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 451515003796 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 451515003797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515003798 non-specific DNA binding site [nucleotide binding]; other site 451515003799 salt bridge; other site 451515003800 sequence-specific DNA binding site [nucleotide binding]; other site 451515003801 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 451515003802 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 451515003803 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 451515003804 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 451515003805 putative MPT binding site; other site 451515003806 recombinase A; Provisional; Region: recA; PRK09354 451515003807 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 451515003808 hexamer interface [polypeptide binding]; other site 451515003809 Walker A motif; other site 451515003810 ATP binding site [chemical binding]; other site 451515003811 Walker B motif; other site 451515003812 phosphodiesterase; Provisional; Region: PRK12704 451515003813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 451515003814 Zn2+ binding site [ion binding]; other site 451515003815 Mg2+ binding site [ion binding]; other site 451515003816 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 451515003817 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 451515003818 putative active site [active] 451515003819 metal binding site [ion binding]; metal-binding site 451515003820 homodimer binding site [polypeptide binding]; other site 451515003821 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 451515003822 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 451515003823 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 451515003824 dimer interface [polypeptide binding]; other site 451515003825 PYR/PP interface [polypeptide binding]; other site 451515003826 TPP binding site [chemical binding]; other site 451515003827 substrate binding site [chemical binding]; other site 451515003828 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 451515003829 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 451515003830 TPP-binding site [chemical binding]; other site 451515003831 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 451515003832 Uncharacterized conserved protein [Function unknown]; Region: COG0011 451515003833 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 451515003834 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 451515003835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515003836 FeS/SAM binding site; other site 451515003837 TRAM domain; Region: TRAM; pfam01938 451515003838 Predicted membrane protein [Function unknown]; Region: COG4550 451515003839 Predicted membrane protein [Function unknown]; Region: COG4732 451515003840 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 451515003841 MutS domain I; Region: MutS_I; pfam01624 451515003842 MutS domain II; Region: MutS_II; pfam05188 451515003843 MutS domain III; Region: MutS_III; pfam05192 451515003844 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 451515003845 Walker A/P-loop; other site 451515003846 ATP binding site [chemical binding]; other site 451515003847 Q-loop/lid; other site 451515003848 ABC transporter signature motif; other site 451515003849 Walker B; other site 451515003850 D-loop; other site 451515003851 H-loop/switch region; other site 451515003852 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 451515003853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515003854 ATP binding site [chemical binding]; other site 451515003855 Mg2+ binding site [ion binding]; other site 451515003856 G-X-G motif; other site 451515003857 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 451515003858 ATP binding site [chemical binding]; other site 451515003859 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 451515003860 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 451515003861 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 451515003862 amphipathic channel; other site 451515003863 Asn-Pro-Ala signature motifs; other site 451515003864 glycerol kinase; Provisional; Region: glpK; PRK00047 451515003865 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 451515003866 N- and C-terminal domain interface [polypeptide binding]; other site 451515003867 active site 451515003868 MgATP binding site [chemical binding]; other site 451515003869 catalytic site [active] 451515003870 metal binding site [ion binding]; metal-binding site 451515003871 glycerol binding site [chemical binding]; other site 451515003872 homotetramer interface [polypeptide binding]; other site 451515003873 homodimer interface [polypeptide binding]; other site 451515003874 FBP binding site [chemical binding]; other site 451515003875 protein IIAGlc interface [polypeptide binding]; other site 451515003876 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 451515003877 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 451515003878 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 451515003879 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 451515003880 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 451515003881 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 451515003882 bacterial Hfq-like; Region: Hfq; cd01716 451515003883 hexamer interface [polypeptide binding]; other site 451515003884 Sm1 motif; other site 451515003885 RNA binding site [nucleotide binding]; other site 451515003886 Sm2 motif; other site 451515003887 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 451515003888 catalytic residues [active] 451515003889 dimer interface [polypeptide binding]; other site 451515003890 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 451515003891 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 451515003892 HflX GTPase family; Region: HflX; cd01878 451515003893 G1 box; other site 451515003894 GTP/Mg2+ binding site [chemical binding]; other site 451515003895 Switch I region; other site 451515003896 G2 box; other site 451515003897 G3 box; other site 451515003898 Switch II region; other site 451515003899 G4 box; other site 451515003900 G5 box; other site 451515003901 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 451515003902 Aluminium resistance protein; Region: Alum_res; pfam06838 451515003903 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 451515003904 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 451515003905 DNA binding residues [nucleotide binding] 451515003906 putative dimer interface [polypeptide binding]; other site 451515003907 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 451515003908 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 451515003909 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 451515003910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 451515003911 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 451515003912 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 451515003913 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 451515003914 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 451515003915 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 451515003916 catalytic residue [active] 451515003917 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 451515003918 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 451515003919 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 451515003920 putative active site [active] 451515003921 catalytic site [active] 451515003922 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 451515003923 putative active site [active] 451515003924 catalytic site [active] 451515003925 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 451515003926 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 451515003927 Walker A/P-loop; other site 451515003928 ATP binding site [chemical binding]; other site 451515003929 Q-loop/lid; other site 451515003930 ABC transporter signature motif; other site 451515003931 Walker B; other site 451515003932 D-loop; other site 451515003933 H-loop/switch region; other site 451515003934 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 451515003935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 451515003936 Histidine kinase; Region: HisKA_3; pfam07730 451515003937 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 451515003938 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 451515003939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515003940 active site 451515003941 phosphorylation site [posttranslational modification] 451515003942 intermolecular recognition site; other site 451515003943 dimerization interface [polypeptide binding]; other site 451515003944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 451515003945 DNA binding residues [nucleotide binding] 451515003946 dimerization interface [polypeptide binding]; other site 451515003947 Staphylococcal nuclease homologues; Region: SNc; smart00318 451515003948 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 451515003949 Catalytic site; other site 451515003950 AAA domain; Region: AAA_11; pfam13086 451515003951 aspartate kinase; Reviewed; Region: PRK09034 451515003952 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 451515003953 putative catalytic residues [active] 451515003954 putative nucleotide binding site [chemical binding]; other site 451515003955 putative aspartate binding site [chemical binding]; other site 451515003956 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 451515003957 allosteric regulatory residue; other site 451515003958 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 451515003959 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 451515003960 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 451515003961 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 451515003962 threonine synthase; Reviewed; Region: PRK06721 451515003963 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 451515003964 homodimer interface [polypeptide binding]; other site 451515003965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515003966 catalytic residue [active] 451515003967 homoserine kinase; Provisional; Region: PRK01212 451515003968 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 451515003969 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 451515003970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515003971 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 451515003972 active site 451515003973 motif I; other site 451515003974 motif II; other site 451515003975 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 451515003976 lysine transporter; Provisional; Region: PRK10836 451515003977 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 451515003978 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 451515003979 tetramer interface [polypeptide binding]; other site 451515003980 heme binding pocket [chemical binding]; other site 451515003981 NADPH binding site [chemical binding]; other site 451515003982 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 451515003983 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 451515003984 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 451515003985 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 451515003986 active site 451515003987 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 451515003988 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 451515003989 LexA repressor; Validated; Region: PRK00215 451515003990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 451515003991 putative DNA binding site [nucleotide binding]; other site 451515003992 putative Zn2+ binding site [ion binding]; other site 451515003993 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 451515003994 Catalytic site [active] 451515003995 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 451515003996 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 451515003997 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 451515003998 TPP-binding site [chemical binding]; other site 451515003999 dimer interface [polypeptide binding]; other site 451515004000 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 451515004001 PYR/PP interface [polypeptide binding]; other site 451515004002 dimer interface [polypeptide binding]; other site 451515004003 TPP binding site [chemical binding]; other site 451515004004 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 451515004005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 451515004006 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 451515004007 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 451515004008 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 451515004009 active site 451515004010 metal binding site [ion binding]; metal-binding site 451515004011 DNA binding site [nucleotide binding] 451515004012 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 451515004013 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 451515004014 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 451515004015 Walker A/P-loop; other site 451515004016 ATP binding site [chemical binding]; other site 451515004017 Q-loop/lid; other site 451515004018 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 451515004019 ABC transporter signature motif; other site 451515004020 Walker B; other site 451515004021 D-loop; other site 451515004022 H-loop/switch region; other site 451515004023 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 451515004024 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 451515004025 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 451515004026 aconitate hydratase; Validated; Region: PRK09277 451515004027 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 451515004028 substrate binding site [chemical binding]; other site 451515004029 ligand binding site [chemical binding]; other site 451515004030 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 451515004031 substrate binding site [chemical binding]; other site 451515004032 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 451515004033 active site 451515004034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 451515004035 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 451515004036 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 451515004037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515004038 ATP binding site [chemical binding]; other site 451515004039 Mg2+ binding site [ion binding]; other site 451515004040 G-X-G motif; other site 451515004041 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 451515004042 anchoring element; other site 451515004043 dimer interface [polypeptide binding]; other site 451515004044 ATP binding site [chemical binding]; other site 451515004045 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 451515004046 active site 451515004047 putative metal-binding site [ion binding]; other site 451515004048 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 451515004049 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 451515004050 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 451515004051 CAP-like domain; other site 451515004052 active site 451515004053 primary dimer interface [polypeptide binding]; other site 451515004054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 451515004055 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 451515004056 amino acid carrier protein; Region: agcS; TIGR00835 451515004057 CAT RNA binding domain; Region: CAT_RBD; smart01061 451515004058 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 451515004059 PRD domain; Region: PRD; pfam00874 451515004060 PRD domain; Region: PRD; pfam00874 451515004061 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 451515004062 Domain of unknown function DUF20; Region: UPF0118; pfam01594 451515004063 Predicted integral membrane protein [Function unknown]; Region: COG0392 451515004064 Uncharacterized conserved protein [Function unknown]; Region: COG2898 451515004065 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 451515004066 methionine sulfoxide reductase A; Provisional; Region: PRK14054 451515004067 Transcriptional regulator [Transcription]; Region: LytR; COG1316 451515004068 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 451515004069 active site 1 [active] 451515004070 dimer interface [polypeptide binding]; other site 451515004071 hexamer interface [polypeptide binding]; other site 451515004072 active site 2 [active] 451515004073 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 451515004074 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 451515004075 active site 451515004076 DNA binding site [nucleotide binding] 451515004077 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 451515004078 prephenate dehydrogenase; Validated; Region: PRK06545 451515004079 prephenate dehydrogenase; Validated; Region: PRK08507 451515004080 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 451515004081 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 451515004082 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 451515004083 putative oligomer interface [polypeptide binding]; other site 451515004084 putative active site [active] 451515004085 metal binding site [ion binding]; metal-binding site 451515004086 anthranilate synthase component I; Provisional; Region: PRK13567 451515004087 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 451515004088 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 451515004089 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 451515004090 Glutamine amidotransferase class-I; Region: GATase; pfam00117 451515004091 glutamine binding [chemical binding]; other site 451515004092 catalytic triad [active] 451515004093 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 451515004094 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 451515004095 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 451515004096 active site 451515004097 ribulose/triose binding site [chemical binding]; other site 451515004098 phosphate binding site [ion binding]; other site 451515004099 substrate (anthranilate) binding pocket [chemical binding]; other site 451515004100 product (indole) binding pocket [chemical binding]; other site 451515004101 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 451515004102 active site 451515004103 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 451515004104 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 451515004105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515004106 catalytic residue [active] 451515004107 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 451515004108 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 451515004109 substrate binding site [chemical binding]; other site 451515004110 active site 451515004111 catalytic residues [active] 451515004112 heterodimer interface [polypeptide binding]; other site 451515004113 FemAB family; Region: FemAB; pfam02388 451515004114 FlxA-like protein; Region: FlxA; pfam14282 451515004115 FemAB family; Region: FemAB; pfam02388 451515004116 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 451515004117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515004118 active site 451515004119 motif I; other site 451515004120 motif II; other site 451515004121 SWIM zinc finger; Region: SWIM; pfam04434 451515004122 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 451515004123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515004124 Walker A/P-loop; other site 451515004125 ATP binding site [chemical binding]; other site 451515004126 Q-loop/lid; other site 451515004127 ABC transporter signature motif; other site 451515004128 Walker B; other site 451515004129 D-loop; other site 451515004130 H-loop/switch region; other site 451515004131 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515004132 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 451515004133 Walker A/P-loop; other site 451515004134 ATP binding site [chemical binding]; other site 451515004135 Q-loop/lid; other site 451515004136 ABC transporter signature motif; other site 451515004137 Walker B; other site 451515004138 D-loop; other site 451515004139 H-loop/switch region; other site 451515004140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 451515004141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515004142 dimer interface [polypeptide binding]; other site 451515004143 conserved gate region; other site 451515004144 putative PBP binding loops; other site 451515004145 ABC-ATPase subunit interface; other site 451515004146 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 451515004147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515004148 dimer interface [polypeptide binding]; other site 451515004149 conserved gate region; other site 451515004150 putative PBP binding loops; other site 451515004151 ABC-ATPase subunit interface; other site 451515004152 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 451515004153 oligoendopeptidase F; Region: pepF; TIGR00181 451515004154 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 451515004155 active site 451515004156 Zn binding site [ion binding]; other site 451515004157 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 451515004158 PhoU domain; Region: PhoU; pfam01895 451515004159 PhoU domain; Region: PhoU; pfam01895 451515004160 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 451515004161 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 451515004162 Walker A/P-loop; other site 451515004163 ATP binding site [chemical binding]; other site 451515004164 Q-loop/lid; other site 451515004165 ABC transporter signature motif; other site 451515004166 Walker B; other site 451515004167 D-loop; other site 451515004168 H-loop/switch region; other site 451515004169 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 451515004170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515004171 dimer interface [polypeptide binding]; other site 451515004172 conserved gate region; other site 451515004173 putative PBP binding loops; other site 451515004174 ABC-ATPase subunit interface; other site 451515004175 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 451515004176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515004177 dimer interface [polypeptide binding]; other site 451515004178 conserved gate region; other site 451515004179 ABC-ATPase subunit interface; other site 451515004180 phosphate binding protein; Region: ptsS_2; TIGR02136 451515004181 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 451515004182 S1 domain; Region: S1_2; pfam13509 451515004183 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 451515004184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 451515004185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 451515004186 ABC transporter; Region: ABC_tran_2; pfam12848 451515004187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 451515004188 aspartate kinase; Reviewed; Region: PRK06635 451515004189 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 451515004190 putative nucleotide binding site [chemical binding]; other site 451515004191 putative catalytic residues [active] 451515004192 putative Mg ion binding site [ion binding]; other site 451515004193 putative aspartate binding site [chemical binding]; other site 451515004194 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 451515004195 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 451515004196 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 451515004197 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 451515004198 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 451515004199 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 451515004200 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 451515004201 dimer interface [polypeptide binding]; other site 451515004202 active site 451515004203 catalytic residue [active] 451515004204 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 451515004205 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 451515004206 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 451515004207 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 451515004208 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 451515004209 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 451515004210 active site 451515004211 trimer interface [polypeptide binding]; other site 451515004212 substrate binding site [chemical binding]; other site 451515004213 CoA binding site [chemical binding]; other site 451515004214 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 451515004215 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 451515004216 metal binding site [ion binding]; metal-binding site 451515004217 dimer interface [polypeptide binding]; other site 451515004218 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 451515004219 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 451515004220 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 451515004221 catalytic residue [active] 451515004222 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 451515004223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 451515004224 active site 451515004225 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 451515004226 substrate binding site [chemical binding]; other site 451515004227 catalytic residues [active] 451515004228 dimer interface [polypeptide binding]; other site 451515004229 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 451515004230 DNA-binding site [nucleotide binding]; DNA binding site 451515004231 RNA-binding motif; other site 451515004232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 451515004233 acylphosphatase; Provisional; Region: PRK14431 451515004234 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 451515004235 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 451515004236 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 451515004237 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 451515004238 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 451515004239 metal ion-dependent adhesion site (MIDAS); other site 451515004240 MoxR-like ATPases [General function prediction only]; Region: COG0714 451515004241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515004242 Walker A motif; other site 451515004243 ATP binding site [chemical binding]; other site 451515004244 Walker B motif; other site 451515004245 arginine finger; other site 451515004246 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 451515004247 active site 451515004248 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 451515004249 active site 451515004250 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 451515004251 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 451515004252 E3 interaction surface; other site 451515004253 lipoyl attachment site [posttranslational modification]; other site 451515004254 e3 binding domain; Region: E3_binding; pfam02817 451515004255 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 451515004256 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 451515004257 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 451515004258 TPP-binding site [chemical binding]; other site 451515004259 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 451515004260 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 451515004261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 451515004262 HAMP domain; Region: HAMP; pfam00672 451515004263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 451515004264 dimer interface [polypeptide binding]; other site 451515004265 phosphorylation site [posttranslational modification] 451515004266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515004267 ATP binding site [chemical binding]; other site 451515004268 Mg2+ binding site [ion binding]; other site 451515004269 G-X-G motif; other site 451515004270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 451515004271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515004272 active site 451515004273 phosphorylation site [posttranslational modification] 451515004274 intermolecular recognition site; other site 451515004275 dimerization interface [polypeptide binding]; other site 451515004276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 451515004277 DNA binding site [nucleotide binding] 451515004278 Transposase IS200 like; Region: Y1_Tnp; pfam01797 451515004279 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 451515004280 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 451515004281 active site 451515004282 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 451515004283 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 451515004284 active site 451515004285 homodimer interface [polypeptide binding]; other site 451515004286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515004287 Coenzyme A binding pocket [chemical binding]; other site 451515004288 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 451515004289 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 451515004290 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 451515004291 protein binding site [polypeptide binding]; other site 451515004292 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 451515004293 Catalytic dyad [active] 451515004294 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 451515004295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 451515004296 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 451515004297 HPr interaction site; other site 451515004298 glycerol kinase (GK) interaction site [polypeptide binding]; other site 451515004299 active site 451515004300 phosphorylation site [posttranslational modification] 451515004301 methionine sulfoxide reductase B; Provisional; Region: PRK00222 451515004302 SelR domain; Region: SelR; pfam01641 451515004303 methionine sulfoxide reductase A; Provisional; Region: PRK13014 451515004304 EDD domain protein, DegV family; Region: DegV; TIGR00762 451515004305 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 451515004306 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 451515004307 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 451515004308 folate binding site [chemical binding]; other site 451515004309 NADP+ binding site [chemical binding]; other site 451515004310 thymidylate synthase; Region: thym_sym; TIGR03284 451515004311 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 451515004312 dimerization interface [polypeptide binding]; other site 451515004313 active site 451515004314 Disulphide isomerase; Region: Disulph_isomer; pfam06491 451515004315 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 451515004316 Virulence factor; Region: Virulence_fact; pfam13769 451515004317 HEAT repeats; Region: HEAT_2; pfam13646 451515004318 HEAT repeat; Region: HEAT; pfam02985 451515004319 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 451515004320 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 451515004321 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 451515004322 RNA/DNA hybrid binding site [nucleotide binding]; other site 451515004323 active site 451515004324 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515004325 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 451515004326 GA module; Region: GA; smart00844 451515004327 GA module; Region: GA; smart00844 451515004328 GA module; Region: GA; smart00844 451515004329 GA module; Region: GA; smart00844 451515004330 GA module; Region: GA; smart00844 451515004331 GA module; Region: GA; smart00844 451515004332 GA module; Region: GA; smart00844 451515004333 GA module; Region: GA; smart00844 451515004334 GA module; Region: GA; smart00844 451515004335 GA module; Region: GA; smart00844 451515004336 GA module; Region: GA; smart00844 451515004337 GA module; Region: GA; smart00844 451515004338 GA module; Region: GA; smart00844 451515004339 GA module; Region: GA; smart00844 451515004340 GA module; Region: GA; smart00844 451515004341 GA module; Region: GA; smart00844 451515004342 GA module; Region: GA; smart00844 451515004343 GA module; Region: GA; smart00844 451515004344 GA module; Region: GA; smart00844 451515004345 GA module; Region: GA; pfam01468 451515004346 GA module; Region: GA; smart00844 451515004347 GA module; Region: GA; smart00844 451515004348 GA module; Region: GA; smart00844 451515004349 GA module; Region: GA; smart00844 451515004350 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 451515004351 GA module; Region: GA; smart00844 451515004352 GA module; Region: GA; smart00844 451515004353 GA module; Region: GA; smart00844 451515004354 GA module; Region: GA; smart00844 451515004355 GA module; Region: GA; smart00844 451515004356 GA module; Region: GA; smart00844 451515004357 GA module; Region: GA; smart00844 451515004358 GA module; Region: GA; pfam01468 451515004359 GA module; Region: GA; smart00844 451515004360 GA module; Region: GA; smart00844 451515004361 GA module; Region: GA; smart00844 451515004362 GA module; Region: GA; smart00844 451515004363 GA module; Region: GA; smart00844 451515004364 GA module; Region: GA; smart00844 451515004365 GA module; Region: GA; smart00844 451515004366 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 451515004367 GA module; Region: GA; smart00844 451515004368 GA module; Region: GA; smart00844 451515004369 GA module; Region: GA; smart00844 451515004370 GA module; Region: GA; smart00844 451515004371 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515004372 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515004373 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 451515004374 Amino acid permease; Region: AA_permease_2; pfam13520 451515004375 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 451515004376 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 451515004377 tetramer interface [polypeptide binding]; other site 451515004378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515004379 catalytic residue [active] 451515004380 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 451515004381 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 451515004382 hexamer interface [polypeptide binding]; other site 451515004383 ligand binding site [chemical binding]; other site 451515004384 putative active site [active] 451515004385 NAD(P) binding site [chemical binding]; other site 451515004386 5'-3' exonuclease; Region: 53EXOc; smart00475 451515004387 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 451515004388 active site 451515004389 metal binding site 1 [ion binding]; metal-binding site 451515004390 putative 5' ssDNA interaction site; other site 451515004391 metal binding site 3; metal-binding site 451515004392 metal binding site 2 [ion binding]; metal-binding site 451515004393 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 451515004394 putative DNA binding site [nucleotide binding]; other site 451515004395 putative metal binding site [ion binding]; other site 451515004396 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 451515004397 Dynamin family; Region: Dynamin_N; pfam00350 451515004398 G1 box; other site 451515004399 GTP/Mg2+ binding site [chemical binding]; other site 451515004400 G2 box; other site 451515004401 Switch I region; other site 451515004402 G3 box; other site 451515004403 Switch II region; other site 451515004404 G4 box; other site 451515004405 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 451515004406 Dynamin family; Region: Dynamin_N; pfam00350 451515004407 G1 box; other site 451515004408 GTP/Mg2+ binding site [chemical binding]; other site 451515004409 G2 box; other site 451515004410 Switch I region; other site 451515004411 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 451515004412 G3 box; other site 451515004413 Switch II region; other site 451515004414 GTP/Mg2+ binding site [chemical binding]; other site 451515004415 G4 box; other site 451515004416 G5 box; other site 451515004417 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 451515004418 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 451515004419 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 451515004420 Cobalt transport protein component CbiN; Region: CbiN; cl00842 451515004421 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 451515004422 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 451515004423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 451515004424 cell division protein GpsB; Provisional; Region: PRK14127 451515004425 DivIVA domain; Region: DivI1A_domain; TIGR03544 451515004426 hypothetical protein; Provisional; Region: PRK13660 451515004427 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 451515004428 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 451515004429 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 451515004430 Transglycosylase; Region: Transgly; pfam00912 451515004431 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 451515004432 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 451515004433 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 451515004434 minor groove reading motif; other site 451515004435 helix-hairpin-helix signature motif; other site 451515004436 substrate binding pocket [chemical binding]; other site 451515004437 active site 451515004438 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 451515004439 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 451515004440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 451515004441 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 451515004442 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 451515004443 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 451515004444 putative dimer interface [polypeptide binding]; other site 451515004445 putative anticodon binding site; other site 451515004446 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 451515004447 homodimer interface [polypeptide binding]; other site 451515004448 motif 1; other site 451515004449 motif 2; other site 451515004450 active site 451515004451 motif 3; other site 451515004452 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 451515004453 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 451515004454 active site 451515004455 catalytic site [active] 451515004456 substrate binding site [chemical binding]; other site 451515004457 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 451515004458 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 451515004459 Biotin operon repressor [Transcription]; Region: BirA; COG1654 451515004460 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 451515004461 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 451515004462 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 451515004463 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 451515004464 active site 451515004465 NTP binding site [chemical binding]; other site 451515004466 metal binding triad [ion binding]; metal-binding site 451515004467 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 451515004468 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 451515004469 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 451515004470 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 451515004471 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 451515004472 homodimer interface [polypeptide binding]; other site 451515004473 metal binding site [ion binding]; metal-binding site 451515004474 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 451515004475 Predicted membrane protein [Function unknown]; Region: COG4347 451515004476 Uncharacterized conserved protein [Function unknown]; Region: COG5582 451515004477 UPF0302 domain; Region: UPF0302; pfam08864 451515004478 A short protein domain of unknown function; Region: IDEAL; smart00914 451515004479 TPR repeat; Region: TPR_11; pfam13414 451515004480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 451515004481 binding surface 451515004482 TPR motif; other site 451515004483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 451515004484 TPR motif; other site 451515004485 binding surface 451515004486 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 451515004487 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 451515004488 hinge; other site 451515004489 active site 451515004490 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 451515004491 active site 451515004492 NAD binding site [chemical binding]; other site 451515004493 metal binding site [ion binding]; metal-binding site 451515004494 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 451515004495 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 451515004496 Tetramer interface [polypeptide binding]; other site 451515004497 active site 451515004498 FMN-binding site [chemical binding]; other site 451515004499 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 451515004500 active site 451515004501 multimer interface [polypeptide binding]; other site 451515004502 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 451515004503 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 451515004504 substrate binding pocket [chemical binding]; other site 451515004505 chain length determination region; other site 451515004506 substrate-Mg2+ binding site; other site 451515004507 catalytic residues [active] 451515004508 aspartate-rich region 1; other site 451515004509 active site lid residues [active] 451515004510 aspartate-rich region 2; other site 451515004511 Methyltransferase domain; Region: Methyltransf_31; pfam13847 451515004512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515004513 S-adenosylmethionine binding site [chemical binding]; other site 451515004514 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 451515004515 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 451515004516 IHF dimer interface [polypeptide binding]; other site 451515004517 IHF - DNA interface [nucleotide binding]; other site 451515004518 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 451515004519 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 451515004520 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 451515004521 GTP-binding protein Der; Reviewed; Region: PRK00093 451515004522 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 451515004523 G1 box; other site 451515004524 GTP/Mg2+ binding site [chemical binding]; other site 451515004525 Switch I region; other site 451515004526 G2 box; other site 451515004527 Switch II region; other site 451515004528 G3 box; other site 451515004529 G4 box; other site 451515004530 G5 box; other site 451515004531 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 451515004532 G1 box; other site 451515004533 GTP/Mg2+ binding site [chemical binding]; other site 451515004534 Switch I region; other site 451515004535 G2 box; other site 451515004536 G3 box; other site 451515004537 Switch II region; other site 451515004538 G4 box; other site 451515004539 G5 box; other site 451515004540 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 451515004541 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 451515004542 RNA binding site [nucleotide binding]; other site 451515004543 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 451515004544 RNA binding site [nucleotide binding]; other site 451515004545 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 451515004546 RNA binding site [nucleotide binding]; other site 451515004547 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 451515004548 RNA binding site [nucleotide binding]; other site 451515004549 cytidylate kinase; Provisional; Region: cmk; PRK00023 451515004550 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 451515004551 CMP-binding site; other site 451515004552 The sites determining sugar specificity; other site 451515004553 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 451515004554 active site 451515004555 homotetramer interface [polypeptide binding]; other site 451515004556 homodimer interface [polypeptide binding]; other site 451515004557 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 451515004558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 451515004559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515004560 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 451515004561 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 451515004562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515004563 ATP binding site [chemical binding]; other site 451515004564 putative Mg++ binding site [ion binding]; other site 451515004565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 451515004566 nucleotide binding region [chemical binding]; other site 451515004567 ATP-binding site [chemical binding]; other site 451515004568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 451515004569 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 451515004570 Predicted membrane protein [Function unknown]; Region: COG3601 451515004571 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 451515004572 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 451515004573 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 451515004574 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 451515004575 PhiSA2USA 451515004576 beta-channel forming cytolysin; Region: hlyII; TIGR01002 451515004577 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 451515004578 CHAP domain; Region: CHAP; pfam05257 451515004579 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 451515004580 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 451515004581 active site 451515004582 metal binding site [ion binding]; metal-binding site 451515004583 Bacterial SH3 domain; Region: SH3_5; pfam08460 451515004584 holin, SPP1 family; Region: holin_SPP1; TIGR01592 451515004585 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 451515004586 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 451515004587 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 451515004588 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 451515004589 hypothetical protein; Provisional; Region: PRK05926 451515004590 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 451515004591 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 451515004592 Phage tail protein; Region: Sipho_tail; pfam05709 451515004593 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 451515004594 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 451515004595 linker region; other site 451515004596 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 451515004597 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 451515004598 dimer interface [polypeptide binding]; other site 451515004599 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 451515004600 Peptidase family M23; Region: Peptidase_M23; pfam01551 451515004601 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 451515004602 N-acetyl-D-glucosamine binding site [chemical binding]; other site 451515004603 catalytic residue [active] 451515004604 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 451515004605 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 451515004606 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 451515004607 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 451515004608 oligomerization interface [polypeptide binding]; other site 451515004609 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 451515004610 Phage capsid family; Region: Phage_capsid; pfam05065 451515004611 Clp protease; Region: CLP_protease; pfam00574 451515004612 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 451515004613 oligomer interface [polypeptide binding]; other site 451515004614 active site residues [active] 451515004615 Phage-related protein [Function unknown]; Region: COG4695; cl01923 451515004616 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 451515004617 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 451515004618 Phage terminase, small subunit; Region: Terminase_4; pfam05119 451515004619 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 451515004620 HNH endonuclease; Region: HNH; pfam01844 451515004621 active site 451515004622 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 451515004623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515004624 ATP binding site [chemical binding]; other site 451515004625 putative Mg++ binding site [ion binding]; other site 451515004626 helicase superfamily c-terminal domain; Region: HELICc; smart00490 451515004627 VRR-NUC domain; Region: VRR_NUC; pfam08774 451515004628 Virulence-associated protein E; Region: VirE; pfam05272 451515004629 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 451515004630 Transcriptional activator RinB; Region: RinB; pfam06116 451515004631 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 451515004632 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 451515004633 dUTPase; Region: dUTPase_2; pfam08761 451515004634 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 451515004635 active site 451515004636 homodimer interface [polypeptide binding]; other site 451515004637 metal binding site [ion binding]; metal-binding site 451515004638 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 451515004639 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 451515004640 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 451515004641 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 451515004642 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 451515004643 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 451515004644 active site 451515004645 DNA binding site [nucleotide binding] 451515004646 catalytic site [active] 451515004647 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 451515004648 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 451515004649 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 451515004650 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 451515004651 Homeodomain-like domain; Region: HTH_23; pfam13384 451515004652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515004653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 451515004654 non-specific DNA binding site [nucleotide binding]; other site 451515004655 salt bridge; other site 451515004656 sequence-specific DNA binding site [nucleotide binding]; other site 451515004657 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 451515004658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515004659 non-specific DNA binding site [nucleotide binding]; other site 451515004660 salt bridge; other site 451515004661 sequence-specific DNA binding site [nucleotide binding]; other site 451515004662 Domain of unknown function (DUF955); Region: DUF955; cl01076 451515004663 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 451515004664 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 451515004665 Int/Topo IB signature motif; other site 451515004666 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 451515004667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 451515004668 dimerization interface [polypeptide binding]; other site 451515004669 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 451515004670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 451515004671 dimer interface [polypeptide binding]; other site 451515004672 phosphorylation site [posttranslational modification] 451515004673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515004674 ATP binding site [chemical binding]; other site 451515004675 Mg2+ binding site [ion binding]; other site 451515004676 G-X-G motif; other site 451515004677 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 451515004678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515004679 active site 451515004680 phosphorylation site [posttranslational modification] 451515004681 intermolecular recognition site; other site 451515004682 dimerization interface [polypeptide binding]; other site 451515004683 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 451515004684 DNA binding site [nucleotide binding] 451515004685 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 451515004686 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 451515004687 RNA binding surface [nucleotide binding]; other site 451515004688 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 451515004689 active site 451515004690 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 451515004691 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 451515004692 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 451515004693 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 451515004694 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 451515004695 active site 451515004696 Int/Topo IB signature motif; other site 451515004697 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 451515004698 metal binding site 2 [ion binding]; metal-binding site 451515004699 putative DNA binding helix; other site 451515004700 metal binding site 1 [ion binding]; metal-binding site 451515004701 dimer interface [polypeptide binding]; other site 451515004702 structural Zn2+ binding site [ion binding]; other site 451515004703 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 451515004704 dimer interface [polypeptide binding]; other site 451515004705 ADP-ribose binding site [chemical binding]; other site 451515004706 active site 451515004707 nudix motif; other site 451515004708 metal binding site [ion binding]; metal-binding site 451515004709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 451515004710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 451515004711 active site 451515004712 catalytic tetrad [active] 451515004713 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 451515004714 classical (c) SDRs; Region: SDR_c; cd05233 451515004715 NAD(P) binding site [chemical binding]; other site 451515004716 active site 451515004717 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 451515004718 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 451515004719 ribonuclease Z; Region: RNase_Z; TIGR02651 451515004720 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 451515004721 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 451515004722 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 451515004723 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 451515004724 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 451515004725 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 451515004726 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 451515004727 Ca binding site [ion binding]; other site 451515004728 active site 451515004729 catalytic site [active] 451515004730 Transcriptional regulators [Transcription]; Region: PurR; COG1609 451515004731 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 451515004732 DNA binding site [nucleotide binding] 451515004733 domain linker motif; other site 451515004734 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 451515004735 putative ligand binding site [chemical binding]; other site 451515004736 putative dimerization interface [polypeptide binding]; other site 451515004737 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 451515004738 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 451515004739 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 451515004740 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 451515004741 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 451515004742 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 451515004743 peptidase T-like protein; Region: PepT-like; TIGR01883 451515004744 metal binding site [ion binding]; metal-binding site 451515004745 putative dimer interface [polypeptide binding]; other site 451515004746 Predicted membrane protein [Function unknown]; Region: COG4129 451515004747 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 451515004748 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 451515004749 Disulphide isomerase; Region: Disulph_isomer; pfam06491 451515004750 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 451515004751 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 451515004752 E3 interaction surface; other site 451515004753 lipoyl attachment site [posttranslational modification]; other site 451515004754 e3 binding domain; Region: E3_binding; pfam02817 451515004755 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 451515004756 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 451515004757 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 451515004758 alpha subunit interface [polypeptide binding]; other site 451515004759 TPP binding site [chemical binding]; other site 451515004760 heterodimer interface [polypeptide binding]; other site 451515004761 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 451515004762 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 451515004763 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 451515004764 tetramer interface [polypeptide binding]; other site 451515004765 TPP-binding site [chemical binding]; other site 451515004766 heterodimer interface [polypeptide binding]; other site 451515004767 phosphorylation loop region [posttranslational modification] 451515004768 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 451515004769 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 451515004770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515004771 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 451515004772 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 451515004773 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 451515004774 Walker A/P-loop; other site 451515004775 ATP binding site [chemical binding]; other site 451515004776 Q-loop/lid; other site 451515004777 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 451515004778 ABC transporter signature motif; other site 451515004779 Walker B; other site 451515004780 D-loop; other site 451515004781 H-loop/switch region; other site 451515004782 arginine repressor; Provisional; Region: PRK04280 451515004783 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 451515004784 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 451515004785 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 451515004786 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 451515004787 substrate binding pocket [chemical binding]; other site 451515004788 chain length determination region; other site 451515004789 substrate-Mg2+ binding site; other site 451515004790 catalytic residues [active] 451515004791 aspartate-rich region 1; other site 451515004792 active site lid residues [active] 451515004793 aspartate-rich region 2; other site 451515004794 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 451515004795 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 451515004796 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 451515004797 generic binding surface II; other site 451515004798 generic binding surface I; other site 451515004799 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 451515004800 putative RNA binding site [nucleotide binding]; other site 451515004801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 451515004802 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 451515004803 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 451515004804 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 451515004805 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 451515004806 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 451515004807 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 451515004808 carboxyltransferase (CT) interaction site; other site 451515004809 biotinylation site [posttranslational modification]; other site 451515004810 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 451515004811 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 451515004812 Surface antigen [General function prediction only]; Region: COG3942 451515004813 CHAP domain; Region: CHAP; pfam05257 451515004814 ribonuclease E; Reviewed; Region: rne; PRK10811 451515004815 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 451515004816 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 451515004817 AAA-like domain; Region: AAA_10; pfam12846 451515004818 TcpE family; Region: TcpE; pfam12648 451515004819 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 451515004820 Replication initiation factor; Region: Rep_trans; pfam02486 451515004821 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 451515004822 elongation factor P; Validated; Region: PRK00529 451515004823 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 451515004824 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 451515004825 RNA binding site [nucleotide binding]; other site 451515004826 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 451515004827 RNA binding site [nucleotide binding]; other site 451515004828 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 451515004829 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 451515004830 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 451515004831 active site 451515004832 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 451515004833 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 451515004834 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 451515004835 active site residue [active] 451515004836 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 451515004837 tetramer interface [polypeptide binding]; other site 451515004838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515004839 catalytic residue [active] 451515004840 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 451515004841 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 451515004842 tetramer interface [polypeptide binding]; other site 451515004843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515004844 catalytic residue [active] 451515004845 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 451515004846 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 451515004847 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 451515004848 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 451515004849 ADP binding site [chemical binding]; other site 451515004850 magnesium binding site [ion binding]; other site 451515004851 putative shikimate binding site; other site 451515004852 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 451515004853 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 451515004854 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 451515004855 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 451515004856 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 451515004857 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 451515004858 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 451515004859 Type II/IV secretion system protein; Region: T2SE; pfam00437 451515004860 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 451515004861 Walker A motif; other site 451515004862 ATP binding site [chemical binding]; other site 451515004863 Walker B motif; other site 451515004864 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 451515004865 Uncharacterized conserved protein [Function unknown]; Region: COG0011 451515004866 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 451515004867 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 451515004868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 451515004869 Rhomboid family; Region: Rhomboid; pfam01694 451515004870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 451515004871 binding surface 451515004872 TPR motif; other site 451515004873 Tetratricopeptide repeat; Region: TPR_16; pfam13432 451515004874 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 451515004875 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 451515004876 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 451515004877 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 451515004878 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 451515004879 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 451515004880 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 451515004881 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 451515004882 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 451515004883 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 451515004884 metal binding site 2 [ion binding]; metal-binding site 451515004885 putative DNA binding helix; other site 451515004886 metal binding site 1 [ion binding]; metal-binding site 451515004887 dimer interface [polypeptide binding]; other site 451515004888 structural Zn2+ binding site [ion binding]; other site 451515004889 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 451515004890 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515004891 ABC-ATPase subunit interface; other site 451515004892 dimer interface [polypeptide binding]; other site 451515004893 putative PBP binding regions; other site 451515004894 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 451515004895 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 451515004896 endonuclease IV; Provisional; Region: PRK01060 451515004897 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 451515004898 AP (apurinic/apyrimidinic) site pocket; other site 451515004899 DNA interaction; other site 451515004900 Metal-binding active site; metal-binding site 451515004901 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 451515004902 DEAD-like helicases superfamily; Region: DEXDc; smart00487 451515004903 ATP binding site [chemical binding]; other site 451515004904 Mg++ binding site [ion binding]; other site 451515004905 motif III; other site 451515004906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 451515004907 nucleotide binding region [chemical binding]; other site 451515004908 ATP-binding site [chemical binding]; other site 451515004909 Uncharacterized conserved protein [Function unknown]; Region: COG0327 451515004910 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 451515004911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 451515004912 Uncharacterized conserved protein [Function unknown]; Region: COG0327 451515004913 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 451515004914 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 451515004915 Family of unknown function (DUF633); Region: DUF633; pfam04816 451515004916 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 451515004917 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 451515004918 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 451515004919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 451515004920 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 451515004921 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 451515004922 DNA binding residues [nucleotide binding] 451515004923 DNA primase, catalytic core; Region: dnaG; TIGR01391 451515004924 CHC2 zinc finger; Region: zf-CHC2; pfam01807 451515004925 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 451515004926 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 451515004927 active site 451515004928 metal binding site [ion binding]; metal-binding site 451515004929 interdomain interaction site; other site 451515004930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 451515004931 HTH domain; Region: HTH_11; cl17392 451515004932 FOG: CBS domain [General function prediction only]; Region: COG0517 451515004933 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 451515004934 glycyl-tRNA synthetase; Provisional; Region: PRK04173 451515004935 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 451515004936 motif 1; other site 451515004937 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 451515004938 active site 451515004939 motif 2; other site 451515004940 motif 3; other site 451515004941 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 451515004942 anticodon binding site; other site 451515004943 DNA repair protein RecO; Region: reco; TIGR00613 451515004944 Recombination protein O N terminal; Region: RecO_N; pfam11967 451515004945 Recombination protein O C terminal; Region: RecO_C; pfam02565 451515004946 GTPase Era; Reviewed; Region: era; PRK00089 451515004947 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 451515004948 G1 box; other site 451515004949 GTP/Mg2+ binding site [chemical binding]; other site 451515004950 Switch I region; other site 451515004951 G2 box; other site 451515004952 Switch II region; other site 451515004953 G3 box; other site 451515004954 G4 box; other site 451515004955 G5 box; other site 451515004956 KH domain; Region: KH_2; pfam07650 451515004957 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 451515004958 active site 451515004959 catalytic motif [active] 451515004960 Zn binding site [ion binding]; other site 451515004961 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 451515004962 metal-binding heat shock protein; Provisional; Region: PRK00016 451515004963 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 451515004964 PhoH-like protein; Region: PhoH; pfam02562 451515004965 hypothetical protein; Provisional; Region: PRK13665 451515004966 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 451515004967 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 451515004968 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 451515004969 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 451515004970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515004971 FeS/SAM binding site; other site 451515004972 TRAM domain; Region: TRAM; cl01282 451515004973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 451515004974 RNA methyltransferase, RsmE family; Region: TIGR00046 451515004975 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 451515004976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515004977 S-adenosylmethionine binding site [chemical binding]; other site 451515004978 chaperone protein DnaJ; Provisional; Region: PRK14280 451515004979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 451515004980 HSP70 interaction site [polypeptide binding]; other site 451515004981 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 451515004982 substrate binding site [polypeptide binding]; other site 451515004983 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 451515004984 Zn binding sites [ion binding]; other site 451515004985 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 451515004986 dimer interface [polypeptide binding]; other site 451515004987 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 451515004988 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 451515004989 nucleotide binding site [chemical binding]; other site 451515004990 NEF interaction site [polypeptide binding]; other site 451515004991 SBD interface [polypeptide binding]; other site 451515004992 heat shock protein GrpE; Provisional; Region: PRK14140 451515004993 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 451515004994 dimer interface [polypeptide binding]; other site 451515004995 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 451515004996 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 451515004997 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 451515004998 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 451515004999 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 451515005000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515005001 FeS/SAM binding site; other site 451515005002 HemN C-terminal domain; Region: HemN_C; pfam06969 451515005003 GTP-binding protein LepA; Provisional; Region: PRK05433 451515005004 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 451515005005 G1 box; other site 451515005006 putative GEF interaction site [polypeptide binding]; other site 451515005007 GTP/Mg2+ binding site [chemical binding]; other site 451515005008 Switch I region; other site 451515005009 G2 box; other site 451515005010 G3 box; other site 451515005011 Switch II region; other site 451515005012 G4 box; other site 451515005013 G5 box; other site 451515005014 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 451515005015 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 451515005016 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 451515005017 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 451515005018 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 451515005019 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 451515005020 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 451515005021 Competence protein; Region: Competence; pfam03772 451515005022 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 451515005023 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 451515005024 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 451515005025 catalytic motif [active] 451515005026 Zn binding site [ion binding]; other site 451515005027 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 451515005028 SLBB domain; Region: SLBB; pfam10531 451515005029 Helix-hairpin-helix motif; Region: HHH; pfam00633 451515005030 Methyltransferase domain; Region: Methyltransf_31; pfam13847 451515005031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515005032 S-adenosylmethionine binding site [chemical binding]; other site 451515005033 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 451515005034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 451515005035 Zn2+ binding site [ion binding]; other site 451515005036 Mg2+ binding site [ion binding]; other site 451515005037 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 451515005038 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 451515005039 active site 451515005040 (T/H)XGH motif; other site 451515005041 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 451515005042 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 451515005043 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 451515005044 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 451515005045 shikimate binding site; other site 451515005046 NAD(P) binding site [chemical binding]; other site 451515005047 GTPase YqeH; Provisional; Region: PRK13796 451515005048 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 451515005049 GTP/Mg2+ binding site [chemical binding]; other site 451515005050 G4 box; other site 451515005051 G5 box; other site 451515005052 G1 box; other site 451515005053 Switch I region; other site 451515005054 G2 box; other site 451515005055 G3 box; other site 451515005056 Switch II region; other site 451515005057 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 451515005058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515005059 active site 451515005060 motif I; other site 451515005061 motif II; other site 451515005062 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 451515005063 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 451515005064 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 451515005065 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 451515005066 Fic family protein [Function unknown]; Region: COG3177 451515005067 Fic/DOC family; Region: Fic; pfam02661 451515005068 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 451515005069 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 451515005070 putative active site [active] 451515005071 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 451515005072 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 451515005073 ATP-grasp domain; Region: ATP-grasp_4; cl17255 451515005074 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 451515005075 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 451515005076 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 451515005077 carboxyltransferase (CT) interaction site; other site 451515005078 biotinylation site [posttranslational modification]; other site 451515005079 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 451515005080 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 451515005081 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 451515005082 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 451515005083 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 451515005084 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 451515005085 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 451515005086 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 451515005087 Sugar specificity; other site 451515005088 Pyrimidine base specificity; other site 451515005089 ATP-binding site [chemical binding]; other site 451515005090 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 451515005091 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 451515005092 Peptidase family U32; Region: Peptidase_U32; pfam01136 451515005093 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 451515005094 Peptidase family U32; Region: Peptidase_U32; pfam01136 451515005095 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 451515005096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515005097 S-adenosylmethionine binding site [chemical binding]; other site 451515005098 hypothetical protein; Provisional; Region: PRK13678 451515005099 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 451515005100 hypothetical protein; Provisional; Region: PRK05473 451515005101 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 451515005102 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 451515005103 motif 1; other site 451515005104 active site 451515005105 motif 2; other site 451515005106 motif 3; other site 451515005107 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 451515005108 DHHA1 domain; Region: DHHA1; pfam02272 451515005109 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 451515005110 AAA domain; Region: AAA_30; pfam13604 451515005111 Family description; Region: UvrD_C_2; pfam13538 451515005112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 451515005113 binding surface 451515005114 TPR motif; other site 451515005115 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 451515005116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 451515005117 binding surface 451515005118 TPR motif; other site 451515005119 TPR repeat; Region: TPR_11; pfam13414 451515005120 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 451515005121 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 451515005122 Ligand Binding Site [chemical binding]; other site 451515005123 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 451515005124 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 451515005125 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 451515005126 catalytic residue [active] 451515005127 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 451515005128 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 451515005129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 451515005130 Predicted transcriptional regulator [Transcription]; Region: COG1959 451515005131 Transcriptional regulator; Region: Rrf2; pfam02082 451515005132 recombination factor protein RarA; Reviewed; Region: PRK13342 451515005133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515005134 Walker A motif; other site 451515005135 ATP binding site [chemical binding]; other site 451515005136 Walker B motif; other site 451515005137 arginine finger; other site 451515005138 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 451515005139 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 451515005140 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 451515005141 putative ATP binding site [chemical binding]; other site 451515005142 putative substrate interface [chemical binding]; other site 451515005143 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 451515005144 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 451515005145 dimer interface [polypeptide binding]; other site 451515005146 anticodon binding site; other site 451515005147 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 451515005148 homodimer interface [polypeptide binding]; other site 451515005149 motif 1; other site 451515005150 active site 451515005151 motif 2; other site 451515005152 GAD domain; Region: GAD; pfam02938 451515005153 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 451515005154 motif 3; other site 451515005155 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 451515005156 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 451515005157 dimer interface [polypeptide binding]; other site 451515005158 motif 1; other site 451515005159 active site 451515005160 motif 2; other site 451515005161 motif 3; other site 451515005162 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 451515005163 anticodon binding site; other site 451515005164 Bacterial SH3 domain homologues; Region: SH3b; smart00287 451515005165 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 451515005166 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 451515005167 active site 451515005168 metal binding site [ion binding]; metal-binding site 451515005169 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 451515005170 putative active site [active] 451515005171 dimerization interface [polypeptide binding]; other site 451515005172 putative tRNAtyr binding site [nucleotide binding]; other site 451515005173 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 451515005174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 451515005175 Zn2+ binding site [ion binding]; other site 451515005176 Mg2+ binding site [ion binding]; other site 451515005177 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 451515005178 synthetase active site [active] 451515005179 NTP binding site [chemical binding]; other site 451515005180 metal binding site [ion binding]; metal-binding site 451515005181 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 451515005182 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 451515005183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 451515005184 active site 451515005185 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 451515005186 DHH family; Region: DHH; pfam01368 451515005187 DHHA1 domain; Region: DHHA1; pfam02272 451515005188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 451515005189 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 451515005190 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 451515005191 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 451515005192 Protein export membrane protein; Region: SecD_SecF; pfam02355 451515005193 Preprotein translocase subunit; Region: YajC; pfam02699 451515005194 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 451515005195 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 451515005196 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 451515005197 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 451515005198 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 451515005199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515005200 Walker A motif; other site 451515005201 ATP binding site [chemical binding]; other site 451515005202 Walker B motif; other site 451515005203 arginine finger; other site 451515005204 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 451515005205 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 451515005206 RuvA N terminal domain; Region: RuvA_N; pfam01330 451515005207 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 451515005208 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 451515005209 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 451515005210 GTPase CgtA; Reviewed; Region: obgE; PRK12297 451515005211 GTP1/OBG; Region: GTP1_OBG; pfam01018 451515005212 Obg GTPase; Region: Obg; cd01898 451515005213 G1 box; other site 451515005214 GTP/Mg2+ binding site [chemical binding]; other site 451515005215 Switch I region; other site 451515005216 G2 box; other site 451515005217 G3 box; other site 451515005218 Switch II region; other site 451515005219 G4 box; other site 451515005220 G5 box; other site 451515005221 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 451515005222 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 451515005223 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 451515005224 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 451515005225 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 451515005226 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 451515005227 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 451515005228 rod shape-determining protein MreC; Region: MreC; pfam04085 451515005229 hypothetical protein; Reviewed; Region: PRK00024 451515005230 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 451515005231 MPN+ (JAMM) motif; other site 451515005232 Zinc-binding site [ion binding]; other site 451515005233 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 451515005234 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 451515005235 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 451515005236 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 451515005237 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 451515005238 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 451515005239 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 451515005240 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 451515005241 active site 451515005242 HIGH motif; other site 451515005243 nucleotide binding site [chemical binding]; other site 451515005244 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 451515005245 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 451515005246 active site 451515005247 KMSKS motif; other site 451515005248 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 451515005249 tRNA binding surface [nucleotide binding]; other site 451515005250 anticodon binding site; other site 451515005251 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 451515005252 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 451515005253 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 451515005254 Putative ammonia monooxygenase; Region: AmoA; pfam05145 451515005255 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 451515005256 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 451515005257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 451515005258 inhibitor-cofactor binding pocket; inhibition site 451515005259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515005260 catalytic residue [active] 451515005261 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 451515005262 dimer interface [polypeptide binding]; other site 451515005263 active site 451515005264 Schiff base residues; other site 451515005265 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 451515005266 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 451515005267 active site 451515005268 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 451515005269 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 451515005270 domain interfaces; other site 451515005271 active site 451515005272 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 451515005273 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 451515005274 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 451515005275 tRNA; other site 451515005276 putative tRNA binding site [nucleotide binding]; other site 451515005277 putative NADP binding site [chemical binding]; other site 451515005278 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 451515005279 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 451515005280 G1 box; other site 451515005281 GTP/Mg2+ binding site [chemical binding]; other site 451515005282 Switch I region; other site 451515005283 G2 box; other site 451515005284 G3 box; other site 451515005285 Switch II region; other site 451515005286 G4 box; other site 451515005287 G5 box; other site 451515005288 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 451515005289 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 451515005290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515005291 Walker A motif; other site 451515005292 ATP binding site [chemical binding]; other site 451515005293 Walker B motif; other site 451515005294 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 451515005295 trigger factor; Provisional; Region: tig; PRK01490 451515005296 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 451515005297 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 451515005298 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 451515005299 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 451515005300 23S rRNA binding site [nucleotide binding]; other site 451515005301 L21 binding site [polypeptide binding]; other site 451515005302 L13 binding site [polypeptide binding]; other site 451515005303 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 451515005304 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 451515005305 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 451515005306 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 451515005307 lysine transporter; Provisional; Region: PRK10836 451515005308 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 451515005309 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 451515005310 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 451515005311 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 451515005312 active site 451515005313 dimer interface [polypeptide binding]; other site 451515005314 motif 1; other site 451515005315 motif 2; other site 451515005316 motif 3; other site 451515005317 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 451515005318 anticodon binding site; other site 451515005319 primosomal protein DnaI; Reviewed; Region: PRK08939 451515005320 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 451515005321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515005322 Walker A motif; other site 451515005323 ATP binding site [chemical binding]; other site 451515005324 Walker B motif; other site 451515005325 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 451515005326 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 451515005327 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 451515005328 ATP cone domain; Region: ATP-cone; pfam03477 451515005329 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 451515005330 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 451515005331 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 451515005332 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 451515005333 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 451515005334 CoA-binding site [chemical binding]; other site 451515005335 ATP-binding [chemical binding]; other site 451515005336 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 451515005337 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 451515005338 DNA binding site [nucleotide binding] 451515005339 catalytic residue [active] 451515005340 H2TH interface [polypeptide binding]; other site 451515005341 putative catalytic residues [active] 451515005342 turnover-facilitating residue; other site 451515005343 intercalation triad [nucleotide binding]; other site 451515005344 8OG recognition residue [nucleotide binding]; other site 451515005345 putative reading head residues; other site 451515005346 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 451515005347 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 451515005348 DNA polymerase I; Provisional; Region: PRK05755 451515005349 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 451515005350 active site 451515005351 metal binding site 1 [ion binding]; metal-binding site 451515005352 putative 5' ssDNA interaction site; other site 451515005353 metal binding site 3; metal-binding site 451515005354 metal binding site 2 [ion binding]; metal-binding site 451515005355 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 451515005356 putative DNA binding site [nucleotide binding]; other site 451515005357 putative metal binding site [ion binding]; other site 451515005358 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 451515005359 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 451515005360 active site 451515005361 DNA binding site [nucleotide binding] 451515005362 catalytic site [active] 451515005363 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 451515005364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 451515005365 dimer interface [polypeptide binding]; other site 451515005366 phosphorylation site [posttranslational modification] 451515005367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515005368 ATP binding site [chemical binding]; other site 451515005369 Mg2+ binding site [ion binding]; other site 451515005370 G-X-G motif; other site 451515005371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 451515005372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515005373 active site 451515005374 phosphorylation site [posttranslational modification] 451515005375 intermolecular recognition site; other site 451515005376 dimerization interface [polypeptide binding]; other site 451515005377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 451515005378 DNA binding site [nucleotide binding] 451515005379 isocitrate dehydrogenase; Reviewed; Region: PRK07006 451515005380 isocitrate dehydrogenase; Validated; Region: PRK07362 451515005381 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 451515005382 dimer interface [polypeptide binding]; other site 451515005383 Citrate synthase; Region: Citrate_synt; pfam00285 451515005384 active site 451515005385 citrylCoA binding site [chemical binding]; other site 451515005386 oxalacetate/citrate binding site [chemical binding]; other site 451515005387 coenzyme A binding site [chemical binding]; other site 451515005388 catalytic triad [active] 451515005389 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 451515005390 pyruvate kinase; Provisional; Region: PRK06354 451515005391 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 451515005392 domain interfaces; other site 451515005393 active site 451515005394 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 451515005395 6-phosphofructokinase; Provisional; Region: PRK03202 451515005396 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 451515005397 dimerization interface [polypeptide binding]; other site 451515005398 allosteric effector site; other site 451515005399 active site 451515005400 ADP/pyrophosphate binding site [chemical binding]; other site 451515005401 fructose-1,6-bisphosphate binding site; other site 451515005402 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 451515005403 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 451515005404 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 451515005405 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 451515005406 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 451515005407 Malic enzyme, N-terminal domain; Region: malic; pfam00390 451515005408 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 451515005409 putative NAD(P) binding site [chemical binding]; other site 451515005410 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 451515005411 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 451515005412 active site 451515005413 PHP Thumb interface [polypeptide binding]; other site 451515005414 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 451515005415 generic binding surface I; other site 451515005416 generic binding surface II; other site 451515005417 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 451515005418 DHH family; Region: DHH; pfam01368 451515005419 DHHA1 domain; Region: DHHA1; pfam02272 451515005420 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 451515005421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 451515005422 DNA-binding site [nucleotide binding]; DNA binding site 451515005423 DRTGG domain; Region: DRTGG; pfam07085 451515005424 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 451515005425 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 451515005426 active site 2 [active] 451515005427 active site 1 [active] 451515005428 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 451515005429 Ligand Binding Site [chemical binding]; other site 451515005430 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 451515005431 metal-dependent hydrolase; Provisional; Region: PRK00685 451515005432 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 451515005433 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 451515005434 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 451515005435 active site 451515005436 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 451515005437 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 451515005438 hexamer interface [polypeptide binding]; other site 451515005439 ligand binding site [chemical binding]; other site 451515005440 putative active site [active] 451515005441 NAD(P) binding site [chemical binding]; other site 451515005442 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 451515005443 Ligand Binding Site [chemical binding]; other site 451515005444 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 451515005445 propionate/acetate kinase; Provisional; Region: PRK12379 451515005446 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 451515005447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515005448 S-adenosylmethionine binding site [chemical binding]; other site 451515005449 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 451515005450 dimer interface [polypeptide binding]; other site 451515005451 catalytic triad [active] 451515005452 peroxidatic and resolving cysteines [active] 451515005453 hypothetical protein; Provisional; Region: PRK10621 451515005454 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 451515005455 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 451515005456 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 451515005457 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 451515005458 Ligand Binding Site [chemical binding]; other site 451515005459 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 451515005460 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 451515005461 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 451515005462 catalytic residue [active] 451515005463 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 451515005464 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 451515005465 GAF domain; Region: GAF_2; pfam13185 451515005466 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 451515005467 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 451515005468 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 451515005469 RNA binding surface [nucleotide binding]; other site 451515005470 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 451515005471 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 451515005472 active site 451515005473 catalytic site [active] 451515005474 OsmC-like protein; Region: OsmC; cl00767 451515005475 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 451515005476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 451515005477 catalytic residue [active] 451515005478 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 451515005479 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 451515005480 ligand binding site [chemical binding]; other site 451515005481 NAD binding site [chemical binding]; other site 451515005482 dimerization interface [polypeptide binding]; other site 451515005483 catalytic site [active] 451515005484 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 451515005485 putative L-serine binding site [chemical binding]; other site 451515005486 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 451515005487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515005488 motif II; other site 451515005489 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 451515005490 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 451515005491 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 451515005492 active site turn [active] 451515005493 phosphorylation site [posttranslational modification] 451515005494 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 451515005495 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 451515005496 putative acyl-acceptor binding pocket; other site 451515005497 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 451515005498 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 451515005499 protein binding site [polypeptide binding]; other site 451515005500 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 451515005501 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 451515005502 active site 451515005503 HIGH motif; other site 451515005504 dimer interface [polypeptide binding]; other site 451515005505 KMSKS motif; other site 451515005506 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 451515005507 RNA binding surface [nucleotide binding]; other site 451515005508 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 451515005509 Transglycosylase; Region: Transgly; pfam00912 451515005510 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 451515005511 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 451515005512 NEAr Transporter domain; Region: NEAT; smart00725 451515005513 NEAr Transporter domain; Region: NEAT; smart00725 451515005514 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 451515005515 heme-binding site [chemical binding]; other site 451515005516 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 451515005517 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 451515005518 Potassium binding sites [ion binding]; other site 451515005519 Cesium cation binding sites [ion binding]; other site 451515005520 acetyl-CoA synthetase; Provisional; Region: PRK04319 451515005521 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 451515005522 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 451515005523 active site 451515005524 acyl-activating enzyme (AAE) consensus motif; other site 451515005525 putative CoA binding site [chemical binding]; other site 451515005526 AMP binding site [chemical binding]; other site 451515005527 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 451515005528 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 451515005529 active site 451515005530 Zn binding site [ion binding]; other site 451515005531 catabolite control protein A; Region: ccpA; TIGR01481 451515005532 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 451515005533 DNA binding site [nucleotide binding] 451515005534 domain linker motif; other site 451515005535 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 451515005536 dimerization interface [polypeptide binding]; other site 451515005537 effector binding site; other site 451515005538 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 451515005539 Chorismate mutase type II; Region: CM_2; cl00693 451515005540 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 451515005541 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 451515005542 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 451515005543 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 451515005544 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 451515005545 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 451515005546 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 451515005547 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 451515005548 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 451515005549 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 451515005550 putative tRNA-binding site [nucleotide binding]; other site 451515005551 hypothetical protein; Provisional; Region: PRK13668 451515005552 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 451515005553 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 451515005554 catalytic residues [active] 451515005555 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 451515005556 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 451515005557 oligomer interface [polypeptide binding]; other site 451515005558 active site 451515005559 metal binding site [ion binding]; metal-binding site 451515005560 Predicted small secreted protein [Function unknown]; Region: COG5584 451515005561 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 451515005562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515005563 S-adenosylmethionine binding site [chemical binding]; other site 451515005564 Phosphotransferase enzyme family; Region: APH; pfam01636 451515005565 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 451515005566 substrate binding site [chemical binding]; other site 451515005567 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 451515005568 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 451515005569 homodimer interface [polypeptide binding]; other site 451515005570 substrate-cofactor binding pocket; other site 451515005571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515005572 catalytic residue [active] 451515005573 dipeptidase PepV; Reviewed; Region: PRK07318 451515005574 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 451515005575 active site 451515005576 metal binding site [ion binding]; metal-binding site 451515005577 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 451515005578 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 451515005579 RNA binding surface [nucleotide binding]; other site 451515005580 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 451515005581 active site 451515005582 uracil binding [chemical binding]; other site 451515005583 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 451515005584 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 451515005585 HI0933-like protein; Region: HI0933_like; pfam03486 451515005586 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515005587 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 451515005588 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005589 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005590 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005591 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005592 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005593 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005594 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005595 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005596 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005597 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005598 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005599 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005600 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005601 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005602 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515005603 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 451515005604 active site residue [active] 451515005605 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 451515005606 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 451515005607 HIGH motif; other site 451515005608 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 451515005609 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 451515005610 active site 451515005611 KMSKS motif; other site 451515005612 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 451515005613 tRNA binding surface [nucleotide binding]; other site 451515005614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515005615 Major Facilitator Superfamily; Region: MFS_1; pfam07690 451515005616 putative substrate translocation pore; other site 451515005617 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 451515005618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515005619 S-adenosylmethionine binding site [chemical binding]; other site 451515005620 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515005621 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 451515005622 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 451515005623 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 451515005624 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 451515005625 homopentamer interface [polypeptide binding]; other site 451515005626 active site 451515005627 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 451515005628 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 451515005629 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 451515005630 dimerization interface [polypeptide binding]; other site 451515005631 active site 451515005632 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 451515005633 Lumazine binding domain; Region: Lum_binding; pfam00677 451515005634 Lumazine binding domain; Region: Lum_binding; pfam00677 451515005635 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 451515005636 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 451515005637 catalytic motif [active] 451515005638 Zn binding site [ion binding]; other site 451515005639 RibD C-terminal domain; Region: RibD_C; cl17279 451515005640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 451515005641 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 451515005642 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 451515005643 dimerization interface [polypeptide binding]; other site 451515005644 putative DNA binding site [nucleotide binding]; other site 451515005645 putative Zn2+ binding site [ion binding]; other site 451515005646 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 451515005647 arsenical pump membrane protein; Provisional; Region: PRK15445 451515005648 transmembrane helices; other site 451515005649 Low molecular weight phosphatase family; Region: LMWPc; cd00115 451515005650 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 451515005651 active site 451515005652 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 451515005653 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 451515005654 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 451515005655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 451515005656 DNA binding residues [nucleotide binding] 451515005657 CAAX protease self-immunity; Region: Abi; pfam02517 451515005658 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 451515005659 active site 451515005660 intersubunit interactions; other site 451515005661 catalytic residue [active] 451515005662 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 451515005663 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 451515005664 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 451515005665 active site 451515005666 catalytic tetrad [active] 451515005667 S-adenosylmethionine synthetase; Validated; Region: PRK05250 451515005668 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 451515005669 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 451515005670 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 451515005671 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 451515005672 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 451515005673 active site 451515005674 substrate-binding site [chemical binding]; other site 451515005675 metal-binding site [ion binding] 451515005676 ATP binding site [chemical binding]; other site 451515005677 Transposase IS200 like; Region: Y1_Tnp; pfam01797 451515005678 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 451515005679 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 451515005680 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 451515005681 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 451515005682 nudix motif; other site 451515005683 Haemolytic domain; Region: Haemolytic; pfam01809 451515005684 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 451515005685 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 451515005686 metal binding site [ion binding]; metal-binding site 451515005687 substrate binding pocket [chemical binding]; other site 451515005688 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 451515005689 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 451515005690 acyl-activating enzyme (AAE) consensus motif; other site 451515005691 putative AMP binding site [chemical binding]; other site 451515005692 putative active site [active] 451515005693 putative CoA binding site [chemical binding]; other site 451515005694 Excalibur calcium-binding domain; Region: Excalibur; smart00894 451515005695 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 451515005696 vSAbeta 451515005697 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 451515005698 Domain of unknown function (DUF955); Region: DUF955; pfam06114 451515005699 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 451515005700 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 451515005701 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 451515005702 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 451515005703 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 451515005704 HsdM N-terminal domain; Region: HsdM_N; pfam12161 451515005705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515005706 S-adenosylmethionine binding site [chemical binding]; other site 451515005707 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 451515005708 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 451515005709 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 451515005710 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 451515005711 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 451515005712 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 451515005713 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 451515005714 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 451515005715 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 451515005716 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 451515005717 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 451515005718 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 451515005719 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 451515005720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515005721 Walker A/P-loop; other site 451515005722 ATP binding site [chemical binding]; other site 451515005723 Q-loop/lid; other site 451515005724 ABC transporter signature motif; other site 451515005725 Walker B; other site 451515005726 D-loop; other site 451515005727 H-loop/switch region; other site 451515005728 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 451515005729 active site 451515005730 catalytic triad [active] 451515005731 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 451515005732 Flavoprotein; Region: Flavoprotein; pfam02441 451515005733 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 451515005734 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 451515005735 active site 451515005736 zinc binding site [ion binding]; other site 451515005737 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 451515005738 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 451515005739 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 451515005740 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 451515005741 beta-channel forming cytolysin; Region: hlyII; TIGR01002 451515005742 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 451515005743 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 451515005744 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 451515005745 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 451515005746 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 451515005747 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 451515005748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 451515005749 ferrochelatase; Provisional; Region: PRK12435 451515005750 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 451515005751 C-terminal domain interface [polypeptide binding]; other site 451515005752 active site 451515005753 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 451515005754 active site 451515005755 N-terminal domain interface [polypeptide binding]; other site 451515005756 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 451515005757 substrate binding site [chemical binding]; other site 451515005758 active site 451515005759 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 451515005760 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 451515005761 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 451515005762 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 451515005763 Walker A/P-loop; other site 451515005764 ATP binding site [chemical binding]; other site 451515005765 Q-loop/lid; other site 451515005766 ABC transporter signature motif; other site 451515005767 Walker B; other site 451515005768 D-loop; other site 451515005769 H-loop/switch region; other site 451515005770 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 451515005771 HIT family signature motif; other site 451515005772 catalytic residue [active] 451515005773 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 451515005774 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 451515005775 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 451515005776 SurA N-terminal domain; Region: SurA_N_3; cl07813 451515005777 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 451515005778 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 451515005779 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 451515005780 generic binding surface II; other site 451515005781 generic binding surface I; other site 451515005782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 451515005783 Zn2+ binding site [ion binding]; other site 451515005784 Mg2+ binding site [ion binding]; other site 451515005785 Uncharacterized conserved protein [Function unknown]; Region: COG4717 451515005786 P-loop containing region of AAA domain; Region: AAA_29; cl17516 451515005787 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 451515005788 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 451515005789 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 451515005790 active site 451515005791 metal binding site [ion binding]; metal-binding site 451515005792 DNA binding site [nucleotide binding] 451515005793 hypothetical protein; Provisional; Region: PRK13676 451515005794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 451515005795 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 451515005796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515005797 non-specific DNA binding site [nucleotide binding]; other site 451515005798 salt bridge; other site 451515005799 sequence-specific DNA binding site [nucleotide binding]; other site 451515005800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 451515005801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515005802 active site 451515005803 phosphorylation site [posttranslational modification] 451515005804 intermolecular recognition site; other site 451515005805 dimerization interface [polypeptide binding]; other site 451515005806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 451515005807 DNA binding residues [nucleotide binding] 451515005808 dimerization interface [polypeptide binding]; other site 451515005809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 451515005810 GAF domain; Region: GAF_3; pfam13492 451515005811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 451515005812 Histidine kinase; Region: HisKA_3; pfam07730 451515005813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515005814 ATP binding site [chemical binding]; other site 451515005815 Mg2+ binding site [ion binding]; other site 451515005816 G-X-G motif; other site 451515005817 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 451515005818 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 451515005819 active site 451515005820 fumarate hydratase; Reviewed; Region: fumC; PRK00485 451515005821 Class II fumarases; Region: Fumarase_classII; cd01362 451515005822 active site 451515005823 tetramer interface [polypeptide binding]; other site 451515005824 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 451515005825 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 451515005826 active site 451515005827 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 451515005828 epoxyqueuosine reductase; Region: TIGR00276 451515005829 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 451515005830 HEAT repeats; Region: HEAT_2; pfam13646 451515005831 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 451515005832 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 451515005833 Walker A/P-loop; other site 451515005834 ATP binding site [chemical binding]; other site 451515005835 Q-loop/lid; other site 451515005836 ABC transporter signature motif; other site 451515005837 Walker B; other site 451515005838 D-loop; other site 451515005839 H-loop/switch region; other site 451515005840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 451515005841 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 451515005842 substrate binding pocket [chemical binding]; other site 451515005843 membrane-bound complex binding site; other site 451515005844 hinge residues; other site 451515005845 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 451515005846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515005847 dimer interface [polypeptide binding]; other site 451515005848 conserved gate region; other site 451515005849 putative PBP binding loops; other site 451515005850 ABC-ATPase subunit interface; other site 451515005851 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 451515005852 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 451515005853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 451515005854 Transposase; Region: DDE_Tnp_ISL3; pfam01610 451515005855 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 451515005856 metal binding site 2 [ion binding]; metal-binding site 451515005857 putative DNA binding helix; other site 451515005858 metal binding site 1 [ion binding]; metal-binding site 451515005859 dimer interface [polypeptide binding]; other site 451515005860 structural Zn2+ binding site [ion binding]; other site 451515005861 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 451515005862 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 451515005863 putative ligand binding site [chemical binding]; other site 451515005864 NAD binding site [chemical binding]; other site 451515005865 catalytic site [active] 451515005866 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 451515005867 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 451515005868 catalytic triad [active] 451515005869 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 451515005870 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 451515005871 inhibitor-cofactor binding pocket; inhibition site 451515005872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515005873 catalytic residue [active] 451515005874 Predicted membrane protein [Function unknown]; Region: COG4129 451515005875 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 451515005876 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 451515005877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 451515005878 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 451515005879 Walker A/P-loop; other site 451515005880 ATP binding site [chemical binding]; other site 451515005881 Q-loop/lid; other site 451515005882 ABC transporter signature motif; other site 451515005883 Walker B; other site 451515005884 D-loop; other site 451515005885 H-loop/switch region; other site 451515005886 hypothetical protein; Provisional; Region: PRK13662 451515005887 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 451515005888 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 451515005889 minor groove reading motif; other site 451515005890 helix-hairpin-helix signature motif; other site 451515005891 substrate binding pocket [chemical binding]; other site 451515005892 active site 451515005893 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 451515005894 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 451515005895 DNA binding and oxoG recognition site [nucleotide binding] 451515005896 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 451515005897 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 451515005898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515005899 Walker A/P-loop; other site 451515005900 ATP binding site [chemical binding]; other site 451515005901 Q-loop/lid; other site 451515005902 ABC transporter signature motif; other site 451515005903 Walker B; other site 451515005904 H-loop/switch region; other site 451515005905 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 451515005906 recombination regulator RecX; Provisional; Region: recX; PRK14135 451515005907 glycosyltransferase; Provisional; Region: PRK13481 451515005908 Transglycosylase; Region: Transgly; pfam00912 451515005909 intracellular protease, PfpI family; Region: PfpI; TIGR01382 451515005910 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 451515005911 proposed catalytic triad [active] 451515005912 conserved cys residue [active] 451515005913 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 451515005914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515005915 FeS/SAM binding site; other site 451515005916 YfkB-like domain; Region: YfkB; pfam08756 451515005917 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 451515005918 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 451515005919 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 451515005920 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 451515005921 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 451515005922 Low molecular weight phosphatase family; Region: LMWPc; cd00115 451515005923 active site 451515005924 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 451515005925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 451515005926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515005927 active site 451515005928 phosphorylation site [posttranslational modification] 451515005929 intermolecular recognition site; other site 451515005930 dimerization interface [polypeptide binding]; other site 451515005931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 451515005932 DNA binding residues [nucleotide binding] 451515005933 dimerization interface [polypeptide binding]; other site 451515005934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 451515005935 Histidine kinase; Region: HisKA_3; pfam07730 451515005936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515005937 ATP binding site [chemical binding]; other site 451515005938 Mg2+ binding site [ion binding]; other site 451515005939 G-X-G motif; other site 451515005940 Predicted membrane protein [Function unknown]; Region: COG4758 451515005941 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 451515005942 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 451515005943 active site 451515005944 Predicted membrane protein [Function unknown]; Region: COG4129 451515005945 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 451515005946 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 451515005947 catalytic triad [active] 451515005948 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 451515005949 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 451515005950 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 451515005951 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 451515005952 Ferritin-like domain; Region: Ferritin; pfam00210 451515005953 ferroxidase diiron center [ion binding]; other site 451515005954 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 451515005955 active site 451515005956 catalytic site [active] 451515005957 substrate binding site [chemical binding]; other site 451515005958 DNA polymerase IV; Validated; Region: PRK02406 451515005959 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 451515005960 active site 451515005961 DNA binding site [nucleotide binding] 451515005962 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 451515005963 TRAM domain; Region: TRAM; cl01282 451515005964 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 451515005965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515005966 S-adenosylmethionine binding site [chemical binding]; other site 451515005967 putative lipid kinase; Reviewed; Region: PRK13337 451515005968 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 451515005969 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 451515005970 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 451515005971 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 451515005972 GatB domain; Region: GatB_Yqey; pfam02637 451515005973 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 451515005974 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 451515005975 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 451515005976 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 451515005977 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 451515005978 Na binding site [ion binding]; other site 451515005979 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 451515005980 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 451515005981 putative dimer interface [polypeptide binding]; other site 451515005982 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 451515005983 putative dimer interface [polypeptide binding]; other site 451515005984 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 451515005985 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 451515005986 nucleotide binding pocket [chemical binding]; other site 451515005987 K-X-D-G motif; other site 451515005988 catalytic site [active] 451515005989 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 451515005990 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 451515005991 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 451515005992 Dimer interface [polypeptide binding]; other site 451515005993 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 451515005994 Part of AAA domain; Region: AAA_19; pfam13245 451515005995 Family description; Region: UvrD_C_2; pfam13538 451515005996 PcrB family; Region: PcrB; pfam01884 451515005997 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 451515005998 substrate binding site [chemical binding]; other site 451515005999 putative active site [active] 451515006000 dimer interface [polypeptide binding]; other site 451515006001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 451515006002 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 451515006003 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 451515006004 tetramer interface [polypeptide binding]; other site 451515006005 active site 451515006006 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 451515006007 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 451515006008 NETI protein; Region: NETI; pfam14044 451515006009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 451515006010 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 451515006011 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 451515006012 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 451515006013 homodimer interface [polypeptide binding]; other site 451515006014 NAD binding pocket [chemical binding]; other site 451515006015 ATP binding pocket [chemical binding]; other site 451515006016 Mg binding site [ion binding]; other site 451515006017 active-site loop [active] 451515006018 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 451515006019 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 451515006020 active site 451515006021 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 451515006022 active site 451515006023 dimer interface [polypeptide binding]; other site 451515006024 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 451515006025 Prephenate dehydratase; Region: PDT; pfam00800 451515006026 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 451515006027 putative L-Phe binding site [chemical binding]; other site 451515006028 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 451515006029 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 451515006030 transmembrane helices; other site 451515006031 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 451515006032 Isochorismatase family; Region: Isochorismatase; pfam00857 451515006033 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 451515006034 catalytic triad [active] 451515006035 conserved cis-peptide bond; other site 451515006036 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 451515006037 DHH family; Region: DHH; pfam01368 451515006038 DHHA2 domain; Region: DHHA2; pfam02833 451515006039 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 451515006040 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 451515006041 NAD(P) binding site [chemical binding]; other site 451515006042 catalytic residues [active] 451515006043 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 451515006044 YolD-like protein; Region: YolD; pfam08863 451515006045 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 451515006046 active site 451515006047 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 451515006048 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 451515006049 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 451515006050 Bacterial PH domain; Region: DUF304; cl01348 451515006051 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 451515006052 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 451515006053 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 451515006054 Walker A/P-loop; other site 451515006055 ATP binding site [chemical binding]; other site 451515006056 Q-loop/lid; other site 451515006057 ABC transporter signature motif; other site 451515006058 Walker B; other site 451515006059 D-loop; other site 451515006060 H-loop/switch region; other site 451515006061 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 451515006062 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 451515006063 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 451515006064 Walker A/P-loop; other site 451515006065 ATP binding site [chemical binding]; other site 451515006066 Q-loop/lid; other site 451515006067 ABC transporter signature motif; other site 451515006068 Walker B; other site 451515006069 D-loop; other site 451515006070 H-loop/switch region; other site 451515006071 Predicted transcriptional regulators [Transcription]; Region: COG1725 451515006072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 451515006073 DNA-binding site [nucleotide binding]; DNA binding site 451515006074 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 451515006075 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 451515006076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515006077 homodimer interface [polypeptide binding]; other site 451515006078 catalytic residue [active] 451515006079 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 451515006080 PhiSA3USA 451515006081 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 451515006082 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 451515006083 Bacterial SH3 domain homologues; Region: SH3b; smart00287 451515006084 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 451515006085 CHAP domain; Region: CHAP; pfam05257 451515006086 Small integral membrane protein [Function unknown]; Region: COG5546 451515006087 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 451515006088 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 451515006089 TolA protein; Region: tolA_full; TIGR02794 451515006090 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 451515006091 Phage tail protein; Region: Sipho_tail; cl17486 451515006092 Phage tail protein; Region: Sipho_tail; cl17486 451515006093 Phage-related minor tail protein [Function unknown]; Region: COG5280 451515006094 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 451515006095 Phage-related protein [Function unknown]; Region: COG5412 451515006096 membrane protein P6; Region: PHA01399 451515006097 Peptidase family M23; Region: Peptidase_M23; pfam01551 451515006098 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 451515006099 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 451515006100 N-acetyl-D-glucosamine binding site [chemical binding]; other site 451515006101 catalytic residue [active] 451515006102 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 451515006103 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 451515006104 Translocation protein Sec62; Region: Sec62; cl02170 451515006105 Phage capsid family; Region: Phage_capsid; pfam05065 451515006106 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 451515006107 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 451515006108 oligomer interface [polypeptide binding]; other site 451515006109 active site residues [active] 451515006110 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 451515006111 Phage-related protein [Function unknown]; Region: COG4695; cl01923 451515006112 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 451515006113 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 451515006114 HNH endonuclease; Region: HNH; pfam01844 451515006115 active site 451515006116 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 451515006117 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 451515006118 Transcriptional activator RinB; Region: RinB; pfam06116 451515006119 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 451515006120 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 451515006121 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 451515006122 trimer interface [polypeptide binding]; other site 451515006123 active site 451515006124 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 451515006125 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 451515006126 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 451515006127 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 451515006128 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 451515006129 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 451515006130 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 451515006131 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 451515006132 dimer interface [polypeptide binding]; other site 451515006133 ssDNA binding site [nucleotide binding]; other site 451515006134 tetramer (dimer of dimers) interface [polypeptide binding]; other site 451515006135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 451515006136 RecT family; Region: RecT; pfam03837 451515006137 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 451515006138 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 451515006139 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 451515006140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 451515006141 Phage anti-repressor protein [Transcription]; Region: COG3561 451515006142 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 451515006143 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 451515006144 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 451515006145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515006146 non-specific DNA binding site [nucleotide binding]; other site 451515006147 salt bridge; other site 451515006148 sequence-specific DNA binding site [nucleotide binding]; other site 451515006149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515006150 non-specific DNA binding site [nucleotide binding]; other site 451515006151 salt bridge; other site 451515006152 sequence-specific DNA binding site [nucleotide binding]; other site 451515006153 Predicted transcriptional regulator [Transcription]; Region: COG2932 451515006154 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 451515006155 Catalytic site [active] 451515006156 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 451515006157 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 451515006158 active site 451515006159 catalytic site [active] 451515006160 substrate binding site [chemical binding]; other site 451515006161 PemK-like protein; Region: PemK; pfam02452 451515006162 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 451515006163 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 451515006164 Int/Topo IB signature motif; other site 451515006165 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 451515006166 putative catalytic site [active] 451515006167 phosphate binding site [ion binding]; other site 451515006168 metal binding site A [ion binding]; metal-binding site 451515006169 metal binding site C [ion binding]; metal-binding site 451515006170 metal binding site B [ion binding]; metal-binding site 451515006171 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 451515006172 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 451515006173 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 451515006174 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 451515006175 metal binding site [ion binding]; metal-binding site 451515006176 dimer interface [polypeptide binding]; other site 451515006177 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 451515006178 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 451515006179 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 451515006180 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 451515006181 putative ligand binding residues [chemical binding]; other site 451515006182 Cation transport protein; Region: TrkH; cl17365 451515006183 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 451515006184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515006185 Coenzyme A binding pocket [chemical binding]; other site 451515006186 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 451515006187 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 451515006188 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 451515006189 ring oligomerisation interface [polypeptide binding]; other site 451515006190 ATP/Mg binding site [chemical binding]; other site 451515006191 stacking interactions; other site 451515006192 hinge regions; other site 451515006193 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 451515006194 oligomerisation interface [polypeptide binding]; other site 451515006195 mobile loop; other site 451515006196 roof hairpin; other site 451515006197 CAAX protease self-immunity; Region: Abi; pfam02517 451515006198 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 451515006199 dimer interface [polypeptide binding]; other site 451515006200 FMN binding site [chemical binding]; other site 451515006201 Predicted amidohydrolase [General function prediction only]; Region: COG0388 451515006202 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 451515006203 putative active site [active] 451515006204 catalytic triad [active] 451515006205 putative dimer interface [polypeptide binding]; other site 451515006206 delta-hemolysin; Provisional; Region: PRK14752 451515006207 Accessory gene regulator B; Region: AgrB; smart00793 451515006208 Staphylococcal AgrD protein; Region: AgrD; smart00794 451515006209 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 451515006210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515006211 Mg2+ binding site [ion binding]; other site 451515006212 G-X-G motif; other site 451515006213 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 451515006214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515006215 active site 451515006216 phosphorylation site [posttranslational modification] 451515006217 intermolecular recognition site; other site 451515006218 dimerization interface [polypeptide binding]; other site 451515006219 LytTr DNA-binding domain; Region: LytTR; pfam04397 451515006220 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 451515006221 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 451515006222 putative substrate binding site [chemical binding]; other site 451515006223 putative ATP binding site [chemical binding]; other site 451515006224 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 451515006225 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 451515006226 substrate binding [chemical binding]; other site 451515006227 active site 451515006228 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 451515006229 Transcriptional regulators [Transcription]; Region: PurR; COG1609 451515006230 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 451515006231 DNA binding site [nucleotide binding] 451515006232 domain linker motif; other site 451515006233 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 451515006234 dimerization interface [polypeptide binding]; other site 451515006235 ligand binding site [chemical binding]; other site 451515006236 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 451515006237 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 451515006238 CPxP motif; other site 451515006239 Predicted transporter component [General function prediction only]; Region: COG2391 451515006240 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 451515006241 Sulphur transport; Region: Sulf_transp; pfam04143 451515006242 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 451515006243 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 451515006244 CoA binding domain; Region: CoA_binding; pfam02629 451515006245 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 451515006246 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 451515006247 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 451515006248 ABC transporter; Region: ABC_tran_2; pfam12848 451515006249 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 451515006250 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 451515006251 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 451515006252 Walker A/P-loop; other site 451515006253 ATP binding site [chemical binding]; other site 451515006254 Q-loop/lid; other site 451515006255 ABC transporter signature motif; other site 451515006256 Walker B; other site 451515006257 D-loop; other site 451515006258 H-loop/switch region; other site 451515006259 UGMP family protein; Validated; Region: PRK09604 451515006260 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 451515006261 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 451515006262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515006263 Coenzyme A binding pocket [chemical binding]; other site 451515006264 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 451515006265 Glycoprotease family; Region: Peptidase_M22; pfam00814 451515006266 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 451515006267 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 451515006268 6-phosphogluconate dehydratase; Region: edd; TIGR01196 451515006269 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 451515006270 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 451515006271 PYR/PP interface [polypeptide binding]; other site 451515006272 dimer interface [polypeptide binding]; other site 451515006273 TPP binding site [chemical binding]; other site 451515006274 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 451515006275 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 451515006276 TPP-binding site [chemical binding]; other site 451515006277 dimer interface [polypeptide binding]; other site 451515006278 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 451515006279 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 451515006280 ketol-acid reductoisomerase; Provisional; Region: PRK05479 451515006281 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 451515006282 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 451515006283 2-isopropylmalate synthase; Validated; Region: PRK00915 451515006284 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 451515006285 active site 451515006286 catalytic residues [active] 451515006287 metal binding site [ion binding]; metal-binding site 451515006288 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 451515006289 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 451515006290 tartrate dehydrogenase; Region: TTC; TIGR02089 451515006291 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 451515006292 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 451515006293 substrate binding site [chemical binding]; other site 451515006294 ligand binding site [chemical binding]; other site 451515006295 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 451515006296 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 451515006297 substrate binding site [chemical binding]; other site 451515006298 threonine dehydratase; Validated; Region: PRK08639 451515006299 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 451515006300 tetramer interface [polypeptide binding]; other site 451515006301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515006302 catalytic residue [active] 451515006303 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 451515006304 putative Ile/Val binding site [chemical binding]; other site 451515006305 hypothetical protein; Provisional; Region: PRK04351 451515006306 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 451515006307 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 451515006308 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 451515006309 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 451515006310 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 451515006311 RNA binding site [nucleotide binding]; other site 451515006312 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 451515006313 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 451515006314 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 451515006315 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 451515006316 DNA binding residues [nucleotide binding] 451515006317 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 451515006318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515006319 ATP binding site [chemical binding]; other site 451515006320 Mg2+ binding site [ion binding]; other site 451515006321 G-X-G motif; other site 451515006322 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 451515006323 anti sigma factor interaction site; other site 451515006324 regulatory phosphorylation site [posttranslational modification]; other site 451515006325 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 451515006326 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 451515006327 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 451515006328 PemK-like protein; Region: PemK; pfam02452 451515006329 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 451515006330 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 451515006331 active site 451515006332 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 451515006333 dimer interface [polypeptide binding]; other site 451515006334 substrate binding site [chemical binding]; other site 451515006335 catalytic residues [active] 451515006336 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 451515006337 Uncharacterized conserved protein [Function unknown]; Region: COG3402 451515006338 Predicted membrane protein [Function unknown]; Region: COG3428 451515006339 Bacterial PH domain; Region: DUF304; pfam03703 451515006340 Bacterial PH domain; Region: DUF304; pfam03703 451515006341 Bacterial PH domain; Region: DUF304; cl01348 451515006342 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 451515006343 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 451515006344 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 451515006345 Soluble P-type ATPase [General function prediction only]; Region: COG4087 451515006346 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 451515006347 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 451515006348 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 451515006349 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 451515006350 Ligand Binding Site [chemical binding]; other site 451515006351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 451515006352 dimer interface [polypeptide binding]; other site 451515006353 phosphorylation site [posttranslational modification] 451515006354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515006355 ATP binding site [chemical binding]; other site 451515006356 Mg2+ binding site [ion binding]; other site 451515006357 G-X-G motif; other site 451515006358 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 451515006359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515006360 active site 451515006361 phosphorylation site [posttranslational modification] 451515006362 intermolecular recognition site; other site 451515006363 dimerization interface [polypeptide binding]; other site 451515006364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 451515006365 DNA binding site [nucleotide binding] 451515006366 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 451515006367 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 451515006368 ATP binding site [chemical binding]; other site 451515006369 Mg++ binding site [ion binding]; other site 451515006370 motif III; other site 451515006371 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 451515006372 nucleotide binding region [chemical binding]; other site 451515006373 ATP-binding site [chemical binding]; other site 451515006374 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 451515006375 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 451515006376 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 451515006377 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 451515006378 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 451515006379 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 451515006380 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 451515006381 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 451515006382 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 451515006383 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 451515006384 putative homodimer interface [polypeptide binding]; other site 451515006385 putative homotetramer interface [polypeptide binding]; other site 451515006386 allosteric switch controlling residues; other site 451515006387 putative metal binding site [ion binding]; other site 451515006388 putative homodimer-homodimer interface [polypeptide binding]; other site 451515006389 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 451515006390 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 451515006391 putative active site [active] 451515006392 catalytic site [active] 451515006393 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 451515006394 putative active site [active] 451515006395 catalytic site [active] 451515006396 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 451515006397 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 451515006398 Zn2+ binding site [ion binding]; other site 451515006399 Mg2+ binding site [ion binding]; other site 451515006400 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 451515006401 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 451515006402 thiamine phosphate binding site [chemical binding]; other site 451515006403 active site 451515006404 pyrophosphate binding site [ion binding]; other site 451515006405 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 451515006406 substrate binding site [chemical binding]; other site 451515006407 multimerization interface [polypeptide binding]; other site 451515006408 ATP binding site [chemical binding]; other site 451515006409 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 451515006410 dimer interface [polypeptide binding]; other site 451515006411 substrate binding site [chemical binding]; other site 451515006412 ATP binding site [chemical binding]; other site 451515006413 thiaminase II; Region: salvage_TenA; TIGR04306 451515006414 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 451515006415 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 451515006416 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 451515006417 dimer interface [polypeptide binding]; other site 451515006418 ssDNA binding site [nucleotide binding]; other site 451515006419 tetramer (dimer of dimers) interface [polypeptide binding]; other site 451515006420 YwpF-like protein; Region: YwpF; pfam14183 451515006421 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 451515006422 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 451515006423 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 451515006424 hinge; other site 451515006425 active site 451515006426 Predicted membrane protein [Function unknown]; Region: COG4836 451515006427 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 451515006428 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 451515006429 gamma subunit interface [polypeptide binding]; other site 451515006430 epsilon subunit interface [polypeptide binding]; other site 451515006431 LBP interface [polypeptide binding]; other site 451515006432 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 451515006433 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 451515006434 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 451515006435 alpha subunit interaction interface [polypeptide binding]; other site 451515006436 Walker A motif; other site 451515006437 ATP binding site [chemical binding]; other site 451515006438 Walker B motif; other site 451515006439 inhibitor binding site; inhibition site 451515006440 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 451515006441 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 451515006442 core domain interface [polypeptide binding]; other site 451515006443 delta subunit interface [polypeptide binding]; other site 451515006444 epsilon subunit interface [polypeptide binding]; other site 451515006445 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 451515006446 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 451515006447 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 451515006448 beta subunit interaction interface [polypeptide binding]; other site 451515006449 Walker A motif; other site 451515006450 ATP binding site [chemical binding]; other site 451515006451 Walker B motif; other site 451515006452 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 451515006453 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 451515006454 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 451515006455 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 451515006456 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 451515006457 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 451515006458 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 451515006459 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 451515006460 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 451515006461 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 451515006462 active site 451515006463 homodimer interface [polypeptide binding]; other site 451515006464 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 451515006465 active site 451515006466 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 451515006467 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 451515006468 dimer interface [polypeptide binding]; other site 451515006469 active site 451515006470 glycine-pyridoxal phosphate binding site [chemical binding]; other site 451515006471 folate binding site [chemical binding]; other site 451515006472 hypothetical protein; Provisional; Region: PRK13690 451515006473 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 451515006474 Low molecular weight phosphatase family; Region: LMWPc; cd00115 451515006475 active site 451515006476 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 451515006477 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 451515006478 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 451515006479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515006480 S-adenosylmethionine binding site [chemical binding]; other site 451515006481 peptide chain release factor 1; Validated; Region: prfA; PRK00591 451515006482 This domain is found in peptide chain release factors; Region: PCRF; smart00937 451515006483 RF-1 domain; Region: RF-1; pfam00472 451515006484 thymidine kinase; Provisional; Region: PRK04296 451515006485 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 451515006486 transcription termination factor Rho; Provisional; Region: rho; PRK09376 451515006487 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 451515006488 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 451515006489 RNA binding site [nucleotide binding]; other site 451515006490 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 451515006491 multimer interface [polypeptide binding]; other site 451515006492 Walker A motif; other site 451515006493 ATP binding site [chemical binding]; other site 451515006494 Walker B motif; other site 451515006495 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 451515006496 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 451515006497 NAD binding site [chemical binding]; other site 451515006498 catalytic residues [active] 451515006499 Predicted transcriptional regulators [Transcription]; Region: COG1733 451515006500 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 451515006501 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 451515006502 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 451515006503 hinge; other site 451515006504 active site 451515006505 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 451515006506 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 451515006507 intersubunit interface [polypeptide binding]; other site 451515006508 active site 451515006509 zinc binding site [ion binding]; other site 451515006510 Na+ binding site [ion binding]; other site 451515006511 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 451515006512 CTP synthetase; Validated; Region: pyrG; PRK05380 451515006513 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 451515006514 Catalytic site [active] 451515006515 active site 451515006516 UTP binding site [chemical binding]; other site 451515006517 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 451515006518 active site 451515006519 putative oxyanion hole; other site 451515006520 catalytic triad [active] 451515006521 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 451515006522 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 451515006523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515006524 Coenzyme A binding pocket [chemical binding]; other site 451515006525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 451515006526 Coenzyme A binding pocket [chemical binding]; other site 451515006527 pantothenate kinase; Provisional; Region: PRK13317 451515006528 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 451515006529 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 451515006530 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 451515006531 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 451515006532 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 451515006533 metal binding site [ion binding]; metal-binding site 451515006534 S-ribosylhomocysteinase; Provisional; Region: PRK02260 451515006535 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 451515006536 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 451515006537 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 451515006538 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 451515006539 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 451515006540 intersubunit interface [polypeptide binding]; other site 451515006541 active site 451515006542 catalytic residue [active] 451515006543 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 451515006544 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 451515006545 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 451515006546 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 451515006547 dimerization interface [polypeptide binding]; other site 451515006548 DPS ferroxidase diiron center [ion binding]; other site 451515006549 ion pore; other site 451515006550 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 451515006551 EVE domain; Region: EVE; cl00728 451515006552 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 451515006553 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 451515006554 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 451515006555 NADH(P)-binding; Region: NAD_binding_10; pfam13460 451515006556 NAD(P) binding site [chemical binding]; other site 451515006557 putative active site [active] 451515006558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 451515006559 dimerization interface [polypeptide binding]; other site 451515006560 putative DNA binding site [nucleotide binding]; other site 451515006561 putative Zn2+ binding site [ion binding]; other site 451515006562 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 451515006563 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 451515006564 SAP domain; Region: SAP; pfam02037 451515006565 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 451515006566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515006567 active site 451515006568 motif I; other site 451515006569 motif II; other site 451515006570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515006571 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 451515006572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515006573 Walker A/P-loop; other site 451515006574 ATP binding site [chemical binding]; other site 451515006575 Q-loop/lid; other site 451515006576 ABC transporter signature motif; other site 451515006577 Walker B; other site 451515006578 D-loop; other site 451515006579 H-loop/switch region; other site 451515006580 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 451515006581 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 451515006582 glutaminase active site [active] 451515006583 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 451515006584 dimer interface [polypeptide binding]; other site 451515006585 active site 451515006586 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 451515006587 dimer interface [polypeptide binding]; other site 451515006588 active site 451515006589 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 451515006590 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 451515006591 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 451515006592 active site 451515006593 P-loop; other site 451515006594 phosphorylation site [posttranslational modification] 451515006595 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 451515006596 HTH domain; Region: HTH_11; pfam08279 451515006597 Mga helix-turn-helix domain; Region: Mga; pfam05043 451515006598 PRD domain; Region: PRD; pfam00874 451515006599 PRD domain; Region: PRD; pfam00874 451515006600 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 451515006601 active site 451515006602 P-loop; other site 451515006603 phosphorylation site [posttranslational modification] 451515006604 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 451515006605 active site 451515006606 phosphorylation site [posttranslational modification] 451515006607 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 451515006608 active site 451515006609 phosphorylation site [posttranslational modification] 451515006610 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 451515006611 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 451515006612 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 451515006613 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515006614 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515006615 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515006616 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515006617 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515006618 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 451515006619 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515006620 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515006621 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515006622 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 451515006623 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 451515006624 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 451515006625 active site 451515006626 substrate binding site [chemical binding]; other site 451515006627 metal binding site [ion binding]; metal-binding site 451515006628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 451515006629 YbbR-like protein; Region: YbbR; pfam07949 451515006630 TIGR00159 family protein; Region: TIGR00159 451515006631 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 451515006632 Arginase family; Region: Arginase; cd09989 451515006633 active site 451515006634 Mn binding site [ion binding]; other site 451515006635 oligomer interface [polypeptide binding]; other site 451515006636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 451515006637 Transposase; Region: DDE_Tnp_ISL3; pfam01610 451515006638 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 451515006639 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 451515006640 Walker A motif; other site 451515006641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515006642 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 451515006643 putative substrate translocation pore; other site 451515006644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515006645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 451515006646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515006647 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 451515006648 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 451515006649 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 451515006650 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 451515006651 substrate binding site; other site 451515006652 dimerization interface; other site 451515006653 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 451515006654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 451515006655 Nucleoside recognition; Region: Gate; pfam07670 451515006656 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 451515006657 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515006658 ABC-ATPase subunit interface; other site 451515006659 dimer interface [polypeptide binding]; other site 451515006660 putative PBP binding regions; other site 451515006661 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 451515006662 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 451515006663 ABC-ATPase subunit interface; other site 451515006664 dimer interface [polypeptide binding]; other site 451515006665 putative PBP binding regions; other site 451515006666 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 451515006667 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 451515006668 siderophore binding site; other site 451515006669 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 451515006670 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 451515006671 dimer interface [polypeptide binding]; other site 451515006672 active site 451515006673 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 451515006674 substrate binding site [chemical binding]; other site 451515006675 catalytic residue [active] 451515006676 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 451515006677 IucA / IucC family; Region: IucA_IucC; pfam04183 451515006678 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 451515006679 H+ Antiporter protein; Region: 2A0121; TIGR00900 451515006680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515006681 putative substrate translocation pore; other site 451515006682 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 451515006683 IucA / IucC family; Region: IucA_IucC; pfam04183 451515006684 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 451515006685 Asp23 family; Region: Asp23; pfam03780 451515006686 Small integral membrane protein [Function unknown]; Region: COG5547 451515006687 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 451515006688 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 451515006689 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 451515006690 putative NAD(P) binding site [chemical binding]; other site 451515006691 dimer interface [polypeptide binding]; other site 451515006692 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 451515006693 Prostaglandin dehydrogenases; Region: PGDH; cd05288 451515006694 NAD(P) binding site [chemical binding]; other site 451515006695 substrate binding site [chemical binding]; other site 451515006696 dimer interface [polypeptide binding]; other site 451515006697 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 451515006698 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 451515006699 beta-galactosidase; Region: BGL; TIGR03356 451515006700 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 451515006701 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 451515006702 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 451515006703 active site 451515006704 P-loop; other site 451515006705 phosphorylation site [posttranslational modification] 451515006706 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 451515006707 methionine cluster; other site 451515006708 active site 451515006709 phosphorylation site [posttranslational modification] 451515006710 metal binding site [ion binding]; metal-binding site 451515006711 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 451515006712 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 451515006713 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 451515006714 putative substrate binding site [chemical binding]; other site 451515006715 putative ATP binding site [chemical binding]; other site 451515006716 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 451515006717 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 451515006718 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 451515006719 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 451515006720 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 451515006721 NAD-dependent deacetylase; Provisional; Region: PRK00481 451515006722 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 451515006723 NAD+ binding site [chemical binding]; other site 451515006724 substrate binding site [chemical binding]; other site 451515006725 putative Zn binding site [ion binding]; other site 451515006726 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 451515006727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 451515006728 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 451515006729 active site 451515006730 catalytic tetrad [active] 451515006731 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 451515006732 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 451515006733 DNA binding residues [nucleotide binding] 451515006734 putative dimer interface [polypeptide binding]; other site 451515006735 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 451515006736 substrate binding site [chemical binding]; other site 451515006737 catalytic residues [active] 451515006738 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 451515006739 Peptidase family M23; Region: Peptidase_M23; pfam01551 451515006740 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 451515006741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 451515006742 active site 451515006743 motif I; other site 451515006744 motif II; other site 451515006745 MAP domain; Region: MAP; pfam03642 451515006746 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 451515006747 acetolactate synthase; Reviewed; Region: PRK08617 451515006748 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 451515006749 PYR/PP interface [polypeptide binding]; other site 451515006750 dimer interface [polypeptide binding]; other site 451515006751 TPP binding site [chemical binding]; other site 451515006752 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 451515006753 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 451515006754 TPP-binding site [chemical binding]; other site 451515006755 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 451515006756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515006757 Walker A motif; other site 451515006758 ATP binding site [chemical binding]; other site 451515006759 Walker B motif; other site 451515006760 arginine finger; other site 451515006761 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 451515006762 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 451515006763 23S rRNA interface [nucleotide binding]; other site 451515006764 L3 interface [polypeptide binding]; other site 451515006765 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 451515006766 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 451515006767 dimerization interface 3.5A [polypeptide binding]; other site 451515006768 active site 451515006769 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 451515006770 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 451515006771 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 451515006772 Walker A/P-loop; other site 451515006773 ATP binding site [chemical binding]; other site 451515006774 Q-loop/lid; other site 451515006775 ABC transporter signature motif; other site 451515006776 Walker B; other site 451515006777 D-loop; other site 451515006778 H-loop/switch region; other site 451515006779 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 451515006780 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 451515006781 Walker A/P-loop; other site 451515006782 ATP binding site [chemical binding]; other site 451515006783 Q-loop/lid; other site 451515006784 ABC transporter signature motif; other site 451515006785 Walker B; other site 451515006786 D-loop; other site 451515006787 H-loop/switch region; other site 451515006788 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 451515006789 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 451515006790 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 451515006791 alphaNTD homodimer interface [polypeptide binding]; other site 451515006792 alphaNTD - beta interaction site [polypeptide binding]; other site 451515006793 alphaNTD - beta' interaction site [polypeptide binding]; other site 451515006794 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 451515006795 30S ribosomal protein S11; Validated; Region: PRK05309 451515006796 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 451515006797 30S ribosomal protein S13; Region: bact_S13; TIGR03631 451515006798 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 451515006799 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 451515006800 rRNA binding site [nucleotide binding]; other site 451515006801 predicted 30S ribosome binding site; other site 451515006802 adenylate kinase; Reviewed; Region: adk; PRK00279 451515006803 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 451515006804 AMP-binding site [chemical binding]; other site 451515006805 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 451515006806 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 451515006807 SecY translocase; Region: SecY; pfam00344 451515006808 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 451515006809 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 451515006810 23S rRNA binding site [nucleotide binding]; other site 451515006811 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 451515006812 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 451515006813 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 451515006814 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 451515006815 5S rRNA interface [nucleotide binding]; other site 451515006816 L27 interface [polypeptide binding]; other site 451515006817 23S rRNA interface [nucleotide binding]; other site 451515006818 L5 interface [polypeptide binding]; other site 451515006819 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 451515006820 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 451515006821 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 451515006822 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 451515006823 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 451515006824 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 451515006825 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 451515006826 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 451515006827 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 451515006828 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 451515006829 RNA binding site [nucleotide binding]; other site 451515006830 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 451515006831 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 451515006832 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 451515006833 23S rRNA interface [nucleotide binding]; other site 451515006834 putative translocon interaction site; other site 451515006835 signal recognition particle (SRP54) interaction site; other site 451515006836 L23 interface [polypeptide binding]; other site 451515006837 trigger factor interaction site; other site 451515006838 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 451515006839 23S rRNA interface [nucleotide binding]; other site 451515006840 5S rRNA interface [nucleotide binding]; other site 451515006841 putative antibiotic binding site [chemical binding]; other site 451515006842 L25 interface [polypeptide binding]; other site 451515006843 L27 interface [polypeptide binding]; other site 451515006844 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 451515006845 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 451515006846 G-X-X-G motif; other site 451515006847 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 451515006848 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 451515006849 putative translocon binding site; other site 451515006850 protein-rRNA interface [nucleotide binding]; other site 451515006851 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 451515006852 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 451515006853 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 451515006854 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 451515006855 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 451515006856 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 451515006857 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 451515006858 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 451515006859 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 451515006860 DNA topoisomerase III; Provisional; Region: PRK07726 451515006861 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 451515006862 active site 451515006863 putative interdomain interaction site [polypeptide binding]; other site 451515006864 putative metal-binding site [ion binding]; other site 451515006865 putative nucleotide binding site [chemical binding]; other site 451515006866 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 451515006867 domain I; other site 451515006868 DNA binding groove [nucleotide binding] 451515006869 phosphate binding site [ion binding]; other site 451515006870 domain II; other site 451515006871 domain III; other site 451515006872 nucleotide binding site [chemical binding]; other site 451515006873 catalytic site [active] 451515006874 domain IV; other site 451515006875 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 451515006876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515006877 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 451515006878 Coenzyme A binding pocket [chemical binding]; other site 451515006879 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 451515006880 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 451515006881 Predicted permeases [General function prediction only]; Region: COG0679 451515006882 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 451515006883 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 451515006884 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 451515006885 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 451515006886 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 451515006887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515006888 Major Facilitator Superfamily; Region: MFS_1; pfam07690 451515006889 putative substrate translocation pore; other site 451515006890 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515006891 Transcriptional regulators [Transcription]; Region: MarR; COG1846 451515006892 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 451515006893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515006894 FeS/SAM binding site; other site 451515006895 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 451515006896 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 451515006897 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 451515006898 GTP binding site; other site 451515006899 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 451515006900 MoaE interaction surface [polypeptide binding]; other site 451515006901 MoeB interaction surface [polypeptide binding]; other site 451515006902 thiocarboxylated glycine; other site 451515006903 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 451515006904 MoaE homodimer interface [polypeptide binding]; other site 451515006905 MoaD interaction [polypeptide binding]; other site 451515006906 active site residues [active] 451515006907 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 451515006908 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 451515006909 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 451515006910 dimer interface [polypeptide binding]; other site 451515006911 putative functional site; other site 451515006912 putative MPT binding site; other site 451515006913 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 451515006914 trimer interface [polypeptide binding]; other site 451515006915 dimer interface [polypeptide binding]; other site 451515006916 putative active site [active] 451515006917 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 451515006918 MPT binding site; other site 451515006919 trimer interface [polypeptide binding]; other site 451515006920 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 451515006921 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 451515006922 ATP binding site [chemical binding]; other site 451515006923 substrate interface [chemical binding]; other site 451515006924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515006925 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 451515006926 Walker A/P-loop; other site 451515006927 ATP binding site [chemical binding]; other site 451515006928 Q-loop/lid; other site 451515006929 ABC transporter signature motif; other site 451515006930 Walker B; other site 451515006931 D-loop; other site 451515006932 H-loop/switch region; other site 451515006933 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 451515006934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515006935 dimer interface [polypeptide binding]; other site 451515006936 conserved gate region; other site 451515006937 putative PBP binding loops; other site 451515006938 ABC-ATPase subunit interface; other site 451515006939 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 451515006940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 451515006941 substrate binding pocket [chemical binding]; other site 451515006942 membrane-bound complex binding site; other site 451515006943 hinge residues; other site 451515006944 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 451515006945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515006946 Coenzyme A binding pocket [chemical binding]; other site 451515006947 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 451515006948 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 451515006949 active site 451515006950 dimerization interface [polypeptide binding]; other site 451515006951 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 451515006952 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 451515006953 intersubunit interface [polypeptide binding]; other site 451515006954 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 451515006955 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 451515006956 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 451515006957 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 451515006958 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 451515006959 alpha-gamma subunit interface [polypeptide binding]; other site 451515006960 beta-gamma subunit interface [polypeptide binding]; other site 451515006961 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 451515006962 gamma-beta subunit interface [polypeptide binding]; other site 451515006963 alpha-beta subunit interface [polypeptide binding]; other site 451515006964 urease subunit alpha; Reviewed; Region: ureC; PRK13207 451515006965 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 451515006966 subunit interactions [polypeptide binding]; other site 451515006967 active site 451515006968 flap region; other site 451515006969 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 451515006970 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 451515006971 dimer interface [polypeptide binding]; other site 451515006972 catalytic residues [active] 451515006973 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 451515006974 UreF; Region: UreF; pfam01730 451515006975 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 451515006976 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 451515006977 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515006978 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515006979 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515006980 Helix-turn-helix domain; Region: HTH_18; pfam12833 451515006981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 451515006982 Surface antigen [General function prediction only]; Region: COG3942 451515006983 CHAP domain; Region: CHAP; pfam05257 451515006984 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 451515006985 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 451515006986 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 451515006987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 451515006988 Surface antigen [General function prediction only]; Region: COG3942 451515006989 CHAP domain; Region: CHAP; pfam05257 451515006990 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 451515006991 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 451515006992 putative ligand binding site [chemical binding]; other site 451515006993 putative NAD binding site [chemical binding]; other site 451515006994 catalytic site [active] 451515006995 hypothetical protein; Provisional; Region: PRK06753 451515006996 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 451515006997 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 451515006998 Lysozyme subfamily 2; Region: LYZ2; smart00047 451515006999 Uncharacterized conserved protein [Function unknown]; Region: COG2427 451515007000 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 451515007001 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 451515007002 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 451515007003 4Fe-4S binding domain; Region: Fer4; pfam00037 451515007004 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 451515007005 [4Fe-4S] binding site [ion binding]; other site 451515007006 molybdopterin cofactor binding site; other site 451515007007 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 451515007008 molybdopterin cofactor binding site; other site 451515007009 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 451515007010 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 451515007011 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 451515007012 active site 451515007013 Predicted transcriptional regulator [Transcription]; Region: COG2378 451515007014 HTH domain; Region: HTH_11; pfam08279 451515007015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 451515007016 CAAX protease self-immunity; Region: Abi; pfam02517 451515007017 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 451515007018 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 451515007019 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 451515007020 putative active site [active] 451515007021 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 451515007022 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 451515007023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515007024 active site 451515007025 motif I; other site 451515007026 motif II; other site 451515007027 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 451515007028 Sodium Bile acid symporter family; Region: SBF; pfam01758 451515007029 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 451515007030 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 451515007031 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 451515007032 active site turn [active] 451515007033 phosphorylation site [posttranslational modification] 451515007034 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 451515007035 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 451515007036 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 451515007037 putative active site [active] 451515007038 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 451515007039 putative hydrophobic ligand binding site [chemical binding]; other site 451515007040 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 451515007041 oxidoreductase; Provisional; Region: PRK07985 451515007042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 451515007043 NAD(P) binding site [chemical binding]; other site 451515007044 active site 451515007045 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 451515007046 amidohydrolase; Region: amidohydrolases; TIGR01891 451515007047 metal binding site [ion binding]; metal-binding site 451515007048 dimer interface [polypeptide binding]; other site 451515007049 imidazolonepropionase; Validated; Region: PRK09356 451515007050 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 451515007051 active site 451515007052 urocanate hydratase; Provisional; Region: PRK05414 451515007053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 451515007054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 451515007055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 451515007056 dimerization interface [polypeptide binding]; other site 451515007057 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 451515007058 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 451515007059 putative active site [active] 451515007060 putative Mg binding site [ion binding]; other site 451515007061 formimidoylglutamase; Provisional; Region: PRK13775 451515007062 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 451515007063 putative active site [active] 451515007064 putative metal binding site [ion binding]; other site 451515007065 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 451515007066 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 451515007067 tetramer (dimer of dimers) interface [polypeptide binding]; other site 451515007068 active site 451515007069 dimer interface [polypeptide binding]; other site 451515007070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 451515007071 MOSC domain; Region: MOSC; pfam03473 451515007072 3-alpha domain; Region: 3-alpha; pfam03475 451515007073 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 451515007074 active site 451515007075 catalytic residues [active] 451515007076 Uncharacterized conserved protein [Function unknown]; Region: COG1742 451515007077 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 451515007078 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 451515007079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515007080 Walker A/P-loop; other site 451515007081 ATP binding site [chemical binding]; other site 451515007082 Q-loop/lid; other site 451515007083 ABC transporter signature motif; other site 451515007084 Walker B; other site 451515007085 D-loop; other site 451515007086 H-loop/switch region; other site 451515007087 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 451515007088 Predicted membrane protein [Function unknown]; Region: COG3152 451515007089 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 451515007090 active site 451515007091 DNA binding site [nucleotide binding] 451515007092 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 451515007093 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 451515007094 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 451515007095 homotetramer interface [polypeptide binding]; other site 451515007096 FMN binding site [chemical binding]; other site 451515007097 homodimer contacts [polypeptide binding]; other site 451515007098 putative active site [active] 451515007099 putative substrate binding site [chemical binding]; other site 451515007100 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 451515007101 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 451515007102 oligomer interface [polypeptide binding]; other site 451515007103 metal binding site [ion binding]; metal-binding site 451515007104 metal binding site [ion binding]; metal-binding site 451515007105 putative Cl binding site [ion binding]; other site 451515007106 aspartate ring; other site 451515007107 basic sphincter; other site 451515007108 hydrophobic gate; other site 451515007109 periplasmic entrance; other site 451515007110 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 451515007111 active site 451515007112 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 451515007113 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 451515007114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007115 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 451515007116 putative substrate translocation pore; other site 451515007117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007118 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 451515007119 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 451515007120 HlyD family secretion protein; Region: HlyD_3; pfam13437 451515007121 lipoyl-biotinyl attachment site [posttranslational modification]; other site 451515007122 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 451515007123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007124 putative substrate translocation pore; other site 451515007125 Predicted membrane protein [Function unknown]; Region: COG4640 451515007126 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 451515007127 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 451515007128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 451515007129 putative Zn2+ binding site [ion binding]; other site 451515007130 putative DNA binding site [nucleotide binding]; other site 451515007131 Uncharacterized conserved protein [Function unknown]; Region: COG1434 451515007132 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 451515007133 putative active site [active] 451515007134 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 451515007135 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 451515007136 Walker A/P-loop; other site 451515007137 ATP binding site [chemical binding]; other site 451515007138 Q-loop/lid; other site 451515007139 ABC transporter signature motif; other site 451515007140 Walker B; other site 451515007141 D-loop; other site 451515007142 H-loop/switch region; other site 451515007143 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 451515007144 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 451515007145 FtsX-like permease family; Region: FtsX; pfam02687 451515007146 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 451515007147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515007148 active site 451515007149 phosphorylation site [posttranslational modification] 451515007150 intermolecular recognition site; other site 451515007151 dimerization interface [polypeptide binding]; other site 451515007152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 451515007153 DNA binding site [nucleotide binding] 451515007154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 451515007155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 451515007156 dimerization interface [polypeptide binding]; other site 451515007157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 451515007158 dimer interface [polypeptide binding]; other site 451515007159 phosphorylation site [posttranslational modification] 451515007160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515007161 ATP binding site [chemical binding]; other site 451515007162 Mg2+ binding site [ion binding]; other site 451515007163 G-X-G motif; other site 451515007164 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 451515007165 LytTr DNA-binding domain; Region: LytTR; smart00850 451515007166 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 451515007167 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 451515007168 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 451515007169 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 451515007170 L-lactate permease; Region: Lactate_perm; cl00701 451515007171 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 451515007172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515007173 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 451515007174 Coenzyme A binding pocket [chemical binding]; other site 451515007175 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 451515007176 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 451515007177 NAD(P) binding site [chemical binding]; other site 451515007178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515007179 Coenzyme A binding pocket [chemical binding]; other site 451515007180 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 451515007181 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 451515007182 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515007183 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 451515007184 Predicted membrane protein [Function unknown]; Region: COG1511 451515007185 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 451515007186 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 451515007187 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 451515007188 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 451515007189 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 451515007190 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 451515007191 Cl binding site [ion binding]; other site 451515007192 oligomer interface [polypeptide binding]; other site 451515007193 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 451515007194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 451515007195 active site turn [active] 451515007196 phosphorylation site [posttranslational modification] 451515007197 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 451515007198 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 451515007199 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 451515007200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 451515007201 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 451515007202 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 451515007203 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 451515007204 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 451515007205 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 451515007206 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 451515007207 MarR family; Region: MarR_2; pfam12802 451515007208 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 451515007209 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 451515007210 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 451515007211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007212 putative substrate translocation pore; other site 451515007213 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 451515007214 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 451515007215 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 451515007216 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 451515007217 DNA binding residues [nucleotide binding] 451515007218 dimer interface [polypeptide binding]; other site 451515007219 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 451515007220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 451515007221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515007222 active site 451515007223 phosphorylation site [posttranslational modification] 451515007224 intermolecular recognition site; other site 451515007225 dimerization interface [polypeptide binding]; other site 451515007226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 451515007227 DNA binding residues [nucleotide binding] 451515007228 dimerization interface [polypeptide binding]; other site 451515007229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 451515007230 Histidine kinase; Region: HisKA_3; pfam07730 451515007231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515007232 ATP binding site [chemical binding]; other site 451515007233 Mg2+ binding site [ion binding]; other site 451515007234 G-X-G motif; other site 451515007235 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 451515007236 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 451515007237 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 451515007238 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 451515007239 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 451515007240 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 451515007241 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 451515007242 [4Fe-4S] binding site [ion binding]; other site 451515007243 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 451515007244 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 451515007245 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 451515007246 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 451515007247 molybdopterin cofactor binding site; other site 451515007248 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 451515007249 active site 451515007250 SAM binding site [chemical binding]; other site 451515007251 homodimer interface [polypeptide binding]; other site 451515007252 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 451515007253 [2Fe-2S] cluster binding site [ion binding]; other site 451515007254 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 451515007255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 451515007256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 451515007257 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 451515007258 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 451515007259 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 451515007260 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 451515007261 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 451515007262 putative active site [active] 451515007263 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 451515007264 active site 451515007265 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 451515007266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515007267 Coenzyme A binding pocket [chemical binding]; other site 451515007268 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 451515007269 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 451515007270 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 451515007271 putative hydrophobic ligand binding site [chemical binding]; other site 451515007272 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 451515007273 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 451515007274 intersubunit interface [polypeptide binding]; other site 451515007275 YodA lipocalin-like domain; Region: YodA; pfam09223 451515007276 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 451515007277 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 451515007278 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 451515007279 Thioredoxin; Region: Thioredoxin_4; cl17273 451515007280 FemAB family; Region: FemAB; pfam02388 451515007281 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 451515007282 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 451515007283 Walker A/P-loop; other site 451515007284 ATP binding site [chemical binding]; other site 451515007285 Q-loop/lid; other site 451515007286 ABC transporter signature motif; other site 451515007287 Walker B; other site 451515007288 D-loop; other site 451515007289 H-loop/switch region; other site 451515007290 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 451515007291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515007292 dimer interface [polypeptide binding]; other site 451515007293 conserved gate region; other site 451515007294 putative PBP binding loops; other site 451515007295 ABC-ATPase subunit interface; other site 451515007296 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 451515007297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 451515007298 substrate binding pocket [chemical binding]; other site 451515007299 membrane-bound complex binding site; other site 451515007300 hinge residues; other site 451515007301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007302 putative substrate translocation pore; other site 451515007303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 451515007304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 451515007306 catalytic core [active] 451515007307 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 451515007308 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 451515007309 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 451515007310 B domain; Region: B; pfam02216 451515007311 B domain; Region: B; pfam02216 451515007312 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 451515007313 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 451515007314 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 451515007315 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 451515007316 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 451515007317 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 451515007318 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 451515007319 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 451515007320 catalytic residue [active] 451515007321 biotin synthase; Validated; Region: PRK06256 451515007322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515007323 FeS/SAM binding site; other site 451515007324 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 451515007325 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 451515007326 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 451515007327 inhibitor-cofactor binding pocket; inhibition site 451515007328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515007329 catalytic residue [active] 451515007330 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 451515007331 AAA domain; Region: AAA_26; pfam13500 451515007332 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 451515007333 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 451515007334 Walker A/P-loop; other site 451515007335 ATP binding site [chemical binding]; other site 451515007336 Q-loop/lid; other site 451515007337 ABC transporter signature motif; other site 451515007338 Walker B; other site 451515007339 D-loop; other site 451515007340 H-loop/switch region; other site 451515007341 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 451515007342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 451515007343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515007344 Walker A/P-loop; other site 451515007345 ATP binding site [chemical binding]; other site 451515007346 Q-loop/lid; other site 451515007347 ABC transporter signature motif; other site 451515007348 Walker B; other site 451515007349 D-loop; other site 451515007350 H-loop/switch region; other site 451515007351 Predicted membrane protein [Function unknown]; Region: COG2246 451515007352 GtrA-like protein; Region: GtrA; pfam04138 451515007353 glycerate kinase; Region: TIGR00045 451515007354 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 451515007355 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 451515007356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007357 putative substrate translocation pore; other site 451515007358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 451515007359 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 451515007360 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 451515007361 putative phosphoesterase; Region: acc_ester; TIGR03729 451515007362 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 451515007363 Spore germination protein; Region: Spore_permease; cl17796 451515007364 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 451515007365 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 451515007366 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 451515007367 Beta-lactamase; Region: Beta-lactamase; pfam00144 451515007368 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 451515007369 extended (e) SDRs; Region: SDR_e; cd08946 451515007370 NAD(P) binding site [chemical binding]; other site 451515007371 active site 451515007372 substrate binding site [chemical binding]; other site 451515007373 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 451515007374 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 451515007375 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 451515007376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007377 putative substrate translocation pore; other site 451515007378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515007380 dimer interface [polypeptide binding]; other site 451515007381 conserved gate region; other site 451515007382 ABC-ATPase subunit interface; other site 451515007383 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 451515007384 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 451515007385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515007386 dimer interface [polypeptide binding]; other site 451515007387 conserved gate region; other site 451515007388 putative PBP binding loops; other site 451515007389 ABC-ATPase subunit interface; other site 451515007390 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 451515007391 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 451515007392 Walker A/P-loop; other site 451515007393 ATP binding site [chemical binding]; other site 451515007394 Q-loop/lid; other site 451515007395 ABC transporter signature motif; other site 451515007396 Walker B; other site 451515007397 D-loop; other site 451515007398 H-loop/switch region; other site 451515007399 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 451515007400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 451515007401 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 451515007402 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 451515007403 amino acid transporter; Region: 2A0306; TIGR00909 451515007404 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 451515007405 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 451515007406 substrate binding pocket [chemical binding]; other site 451515007407 catalytic triad [active] 451515007408 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 451515007409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007410 putative substrate translocation pore; other site 451515007411 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 451515007412 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 451515007413 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 451515007414 Walker A/P-loop; other site 451515007415 ATP binding site [chemical binding]; other site 451515007416 Q-loop/lid; other site 451515007417 ABC transporter signature motif; other site 451515007418 Walker B; other site 451515007419 D-loop; other site 451515007420 H-loop/switch region; other site 451515007421 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 451515007422 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 451515007423 oligomer interface [polypeptide binding]; other site 451515007424 active site 451515007425 metal binding site [ion binding]; metal-binding site 451515007426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 451515007427 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 451515007428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 451515007429 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 451515007430 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 451515007431 active site 451515007432 FMN binding site [chemical binding]; other site 451515007433 substrate binding site [chemical binding]; other site 451515007434 3Fe-4S cluster binding site [ion binding]; other site 451515007435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 451515007437 putative substrate translocation pore; other site 451515007438 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 451515007439 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515007440 Walker A/P-loop; other site 451515007441 ATP binding site [chemical binding]; other site 451515007442 Q-loop/lid; other site 451515007443 ABC transporter signature motif; other site 451515007444 Walker B; other site 451515007445 D-loop; other site 451515007446 H-loop/switch region; other site 451515007447 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 451515007448 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 451515007449 Walker A/P-loop; other site 451515007450 ATP binding site [chemical binding]; other site 451515007451 Q-loop/lid; other site 451515007452 ABC transporter signature motif; other site 451515007453 Walker B; other site 451515007454 D-loop; other site 451515007455 H-loop/switch region; other site 451515007456 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 451515007457 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 451515007458 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 451515007459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515007460 dimer interface [polypeptide binding]; other site 451515007461 conserved gate region; other site 451515007462 putative PBP binding loops; other site 451515007463 ABC-ATPase subunit interface; other site 451515007464 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 451515007465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 451515007466 dimer interface [polypeptide binding]; other site 451515007467 conserved gate region; other site 451515007468 putative PBP binding loops; other site 451515007469 ABC-ATPase subunit interface; other site 451515007470 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 451515007471 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 451515007472 substrate binding site [chemical binding]; other site 451515007473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 451515007474 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 451515007475 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 451515007476 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 451515007477 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 451515007478 classical (c) SDRs; Region: SDR_c; cd05233 451515007479 NAD(P) binding site [chemical binding]; other site 451515007480 active site 451515007481 AbgT putative transporter family; Region: ABG_transport; pfam03806 451515007482 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 451515007483 Uncharacterized conserved protein [Function unknown]; Region: COG2128 451515007484 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 451515007485 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 451515007486 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 451515007487 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 451515007488 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 451515007489 classical (c) SDRs; Region: SDR_c; cd05233 451515007490 NAD(P) binding site [chemical binding]; other site 451515007491 active site 451515007492 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515007493 Protein of unknown function, DUF576; Region: DUF576; cl04553 451515007494 Protein of unknown function, DUF576; Region: DUF576; cl04553 451515007495 Protein of unknown function, DUF576; Region: DUF576; pfam04507 451515007496 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 451515007497 PLD-like domain; Region: PLDc_2; pfam13091 451515007498 putative homodimer interface [polypeptide binding]; other site 451515007499 putative active site [active] 451515007500 catalytic site [active] 451515007501 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 451515007502 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 451515007503 ATP binding site [chemical binding]; other site 451515007504 putative Mg++ binding site [ion binding]; other site 451515007505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 451515007506 nucleotide binding region [chemical binding]; other site 451515007507 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 451515007508 ATP-binding site [chemical binding]; other site 451515007509 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 451515007510 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 451515007511 active site 451515007512 8-oxo-dGMP binding site [chemical binding]; other site 451515007513 nudix motif; other site 451515007514 metal binding site [ion binding]; metal-binding site 451515007515 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 451515007516 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 451515007517 active site 451515007518 substrate binding site [chemical binding]; other site 451515007519 metal binding site [ion binding]; metal-binding site 451515007520 H+ Antiporter protein; Region: 2A0121; TIGR00900 451515007521 G5 domain; Region: G5; pfam07501 451515007522 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 451515007523 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515007524 legume lectins; Region: lectin_L-type; cl14058 451515007525 homotetramer interaction site [polypeptide binding]; other site 451515007526 carbohydrate binding site [chemical binding]; other site 451515007527 metal binding site [ion binding]; metal-binding site 451515007528 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515007529 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 451515007530 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515007531 Transcriptional regulators [Transcription]; Region: MarR; COG1846 451515007532 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 451515007533 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 451515007534 tetramer interface; other site 451515007535 active site 451515007536 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515007537 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 451515007538 Fibronectin binding repeat; Region: Fn_bind; pfam02986 451515007539 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 451515007540 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515007541 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 451515007542 Fibronectin binding repeat; Region: Fn_bind; pfam02986 451515007543 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 451515007544 GntP family permease; Region: GntP_permease; pfam02447 451515007545 fructuronate transporter; Provisional; Region: PRK10034; cl15264 451515007546 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 451515007547 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 451515007548 N- and C-terminal domain interface [polypeptide binding]; other site 451515007549 active site 451515007550 catalytic site [active] 451515007551 metal binding site [ion binding]; metal-binding site 451515007552 carbohydrate binding site [chemical binding]; other site 451515007553 ATP binding site [chemical binding]; other site 451515007554 Transcriptional regulators [Transcription]; Region: GntR; COG1802 451515007555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 451515007556 DNA-binding site [nucleotide binding]; DNA binding site 451515007557 FCD domain; Region: FCD; pfam07729 451515007558 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 451515007559 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 451515007560 DNA binding residues [nucleotide binding] 451515007561 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 451515007562 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 451515007563 synthetase active site [active] 451515007564 NTP binding site [chemical binding]; other site 451515007565 metal binding site [ion binding]; metal-binding site 451515007566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 451515007567 Predicted membrane protein [Function unknown]; Region: COG1289 451515007568 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 451515007569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007570 D-galactonate transporter; Region: 2A0114; TIGR00893 451515007571 putative substrate translocation pore; other site 451515007572 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 451515007573 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 451515007574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 451515007575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 451515007576 putative substrate translocation pore; other site 451515007577 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 451515007578 MarR family; Region: MarR; pfam01047 451515007579 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 451515007580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515007581 Walker A/P-loop; other site 451515007582 ATP binding site [chemical binding]; other site 451515007583 Q-loop/lid; other site 451515007584 ABC transporter signature motif; other site 451515007585 Walker B; other site 451515007586 D-loop; other site 451515007587 H-loop/switch region; other site 451515007588 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 451515007589 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 451515007590 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 451515007591 Uncharacterized membrane protein [Function unknown]; Region: COG3949 451515007592 Predicted esterase [General function prediction only]; Region: COG0400 451515007593 putative hydrolase; Provisional; Region: PRK11460 451515007594 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 451515007595 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 451515007596 Zn binding site [ion binding]; other site 451515007597 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 451515007598 MarR family; Region: MarR; pfam01047 451515007599 Predicted acetyltransferase [General function prediction only]; Region: COG2388 451515007600 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 451515007601 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 451515007602 putative metal binding site [ion binding]; other site 451515007603 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 451515007604 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 451515007605 dimer interface [polypeptide binding]; other site 451515007606 FMN binding site [chemical binding]; other site 451515007607 D-lactate dehydrogenase; Provisional; Region: PRK12480 451515007608 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 451515007609 homodimer interface [polypeptide binding]; other site 451515007610 ligand binding site [chemical binding]; other site 451515007611 NAD binding site [chemical binding]; other site 451515007612 catalytic site [active] 451515007613 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 451515007614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 451515007615 active site 451515007616 motif I; other site 451515007617 motif II; other site 451515007618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 451515007619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 451515007620 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 451515007621 Walker A/P-loop; other site 451515007622 ATP binding site [chemical binding]; other site 451515007623 Q-loop/lid; other site 451515007624 ABC transporter signature motif; other site 451515007625 Walker B; other site 451515007626 D-loop; other site 451515007627 H-loop/switch region; other site 451515007628 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 451515007629 active site 451515007630 catalytic site [active] 451515007631 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 451515007632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515007633 Coenzyme A binding pocket [chemical binding]; other site 451515007634 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 451515007635 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 451515007636 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 451515007637 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 451515007638 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 451515007639 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 451515007640 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 451515007641 EamA-like transporter family; Region: EamA; pfam00892 451515007642 EamA-like transporter family; Region: EamA; pfam00892 451515007643 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 451515007644 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 451515007645 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 451515007646 catalytic residues [active] 451515007647 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 451515007648 active site 451515007649 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 451515007650 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 451515007651 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 451515007652 active site turn [active] 451515007653 phosphorylation site [posttranslational modification] 451515007654 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 451515007655 HPr interaction site; other site 451515007656 glycerol kinase (GK) interaction site [polypeptide binding]; other site 451515007657 active site 451515007658 phosphorylation site [posttranslational modification] 451515007659 pyruvate oxidase; Provisional; Region: PRK08611 451515007660 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 451515007661 PYR/PP interface [polypeptide binding]; other site 451515007662 tetramer interface [polypeptide binding]; other site 451515007663 dimer interface [polypeptide binding]; other site 451515007664 TPP binding site [chemical binding]; other site 451515007665 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 451515007666 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 451515007667 TPP-binding site [chemical binding]; other site 451515007668 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 451515007669 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 451515007670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 451515007671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 451515007672 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 451515007673 putative dimerization interface [polypeptide binding]; other site 451515007674 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 451515007675 Surface antigen [General function prediction only]; Region: COG3942 451515007676 CHAP domain; Region: CHAP; pfam05257 451515007677 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 451515007678 homodimer interface [polypeptide binding]; other site 451515007679 catalytic residues [active] 451515007680 NAD binding site [chemical binding]; other site 451515007681 substrate binding pocket [chemical binding]; other site 451515007682 flexible flap; other site 451515007683 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 451515007684 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 451515007685 dimer interface [polypeptide binding]; other site 451515007686 active site 451515007687 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 451515007688 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 451515007689 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 451515007690 DNA binding site [nucleotide binding] 451515007691 active site 451515007692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515007693 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 451515007694 Walker A motif; other site 451515007695 ATP binding site [chemical binding]; other site 451515007696 Walker B motif; other site 451515007697 arginine finger; other site 451515007698 UvrB/uvrC motif; Region: UVR; pfam02151 451515007699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 451515007700 Walker A motif; other site 451515007701 ATP binding site [chemical binding]; other site 451515007702 Walker B motif; other site 451515007703 arginine finger; other site 451515007704 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 451515007705 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 451515007706 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 451515007707 G1 box; other site 451515007708 GTP/Mg2+ binding site [chemical binding]; other site 451515007709 Switch I region; other site 451515007710 G2 box; other site 451515007711 G3 box; other site 451515007712 Switch II region; other site 451515007713 G4 box; other site 451515007714 G5 box; other site 451515007715 Nucleoside recognition; Region: Gate; pfam07670 451515007716 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 451515007717 Nucleoside recognition; Region: Gate; pfam07670 451515007718 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 451515007719 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 451515007720 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 451515007721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 451515007722 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 451515007723 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 451515007724 Glutamate binding site [chemical binding]; other site 451515007725 homodimer interface [polypeptide binding]; other site 451515007726 NAD binding site [chemical binding]; other site 451515007727 catalytic residues [active] 451515007728 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 451515007729 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 451515007730 active site 451515007731 substrate binding site [chemical binding]; other site 451515007732 trimer interface [polypeptide binding]; other site 451515007733 CoA binding site [chemical binding]; other site 451515007734 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 451515007735 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 451515007736 metal-binding site [ion binding] 451515007737 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 451515007738 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 451515007739 metal-binding site [ion binding] 451515007740 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 451515007741 Soluble P-type ATPase [General function prediction only]; Region: COG4087 451515007742 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 451515007743 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 451515007744 metal-binding site [ion binding] 451515007745 D-lactate dehydrogenase; Validated; Region: PRK08605 451515007746 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 451515007747 homodimer interface [polypeptide binding]; other site 451515007748 ligand binding site [chemical binding]; other site 451515007749 NAD binding site [chemical binding]; other site 451515007750 catalytic site [active] 451515007751 transaminase; Reviewed; Region: PRK08068 451515007752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 451515007753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515007754 homodimer interface [polypeptide binding]; other site 451515007755 catalytic residue [active] 451515007756 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 451515007757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 451515007758 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 451515007759 active site lid residues [active] 451515007760 substrate binding pocket [chemical binding]; other site 451515007761 catalytic residues [active] 451515007762 substrate-Mg2+ binding site; other site 451515007763 aspartate-rich region 1; other site 451515007764 aspartate-rich region 2; other site 451515007765 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 451515007766 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 451515007767 active site 451515007768 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 451515007769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 451515007770 Surface antigen [General function prediction only]; Region: COG3942 451515007771 CHAP domain; Region: CHAP; pfam05257 451515007772 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 451515007773 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 451515007774 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 451515007775 catalytic triad [active] 451515007776 catalytic triad [active] 451515007777 oxyanion hole [active] 451515007778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515007779 Coenzyme A binding pocket [chemical binding]; other site 451515007780 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 451515007781 N-acetyl-D-glucosamine binding site [chemical binding]; other site 451515007782 catalytic residue [active] 451515007783 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 451515007784 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 451515007785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 451515007786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 451515007787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 451515007788 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 451515007789 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 451515007790 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 451515007791 NmrA-like family; Region: NmrA; pfam05368 451515007792 NADP binding site [chemical binding]; other site 451515007793 active site 451515007794 regulatory binding site [polypeptide binding]; other site 451515007795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 451515007796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 451515007797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 451515007798 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 451515007799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 451515007800 NAD(P) binding site [chemical binding]; other site 451515007801 active site 451515007802 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 451515007803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 451515007804 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 451515007805 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 451515007806 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 451515007807 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 451515007808 Nucleoside recognition; Region: Gate; pfam07670 451515007809 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 451515007810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 451515007811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 451515007812 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 451515007813 Phosphotransferase enzyme family; Region: APH; pfam01636 451515007814 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 451515007815 active site 451515007816 ATP binding site [chemical binding]; other site 451515007817 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 451515007818 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 451515007819 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 451515007820 quinone interaction residues [chemical binding]; other site 451515007821 active site 451515007822 catalytic residues [active] 451515007823 FMN binding site [chemical binding]; other site 451515007824 substrate binding site [chemical binding]; other site 451515007825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 451515007826 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 451515007827 dimer interface [polypeptide binding]; other site 451515007828 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 451515007829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 451515007830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 451515007831 Predicted acyl esterases [General function prediction only]; Region: COG2936 451515007832 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 451515007833 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 451515007834 tetramerization interface [polypeptide binding]; other site 451515007835 active site 451515007836 pantoate--beta-alanine ligase; Region: panC; TIGR00018 451515007837 Pantoate-beta-alanine ligase; Region: PanC; cd00560 451515007838 active site 451515007839 ATP-binding site [chemical binding]; other site 451515007840 pantoate-binding site; other site 451515007841 HXXH motif; other site 451515007842 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 451515007843 active site 451515007844 oligomerization interface [polypeptide binding]; other site 451515007845 metal binding site [ion binding]; metal-binding site 451515007846 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 451515007847 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 451515007848 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 451515007849 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 451515007850 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 451515007851 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 451515007852 tetramer (dimer of dimers) interface [polypeptide binding]; other site 451515007853 NAD binding site [chemical binding]; other site 451515007854 dimer interface [polypeptide binding]; other site 451515007855 substrate binding site [chemical binding]; other site 451515007856 amino acid transporter; Region: 2A0306; TIGR00909 451515007857 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 451515007858 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 451515007859 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 451515007860 inhibitor-cofactor binding pocket; inhibition site 451515007861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515007862 catalytic residue [active] 451515007863 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 451515007864 catalytic residue [active] 451515007865 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 451515007866 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 451515007867 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 451515007868 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 451515007869 acyl-activating enzyme (AAE) consensus motif; other site 451515007870 AMP binding site [chemical binding]; other site 451515007871 active site 451515007872 CoA binding site [chemical binding]; other site 451515007873 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 451515007874 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 451515007875 choline dehydrogenase; Validated; Region: PRK02106 451515007876 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 451515007877 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 451515007878 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 451515007879 tetramerization interface [polypeptide binding]; other site 451515007880 NAD(P) binding site [chemical binding]; other site 451515007881 catalytic residues [active] 451515007882 Predicted transcriptional regulators [Transcription]; Region: COG1510 451515007883 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 451515007884 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 451515007885 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 451515007886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 451515007887 FeS/SAM binding site; other site 451515007888 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 451515007889 Class III ribonucleotide reductase; Region: RNR_III; cd01675 451515007890 effector binding site; other site 451515007891 active site 451515007892 Zn binding site [ion binding]; other site 451515007893 glycine loop; other site 451515007894 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 451515007895 Citrate transporter; Region: CitMHS; pfam03600 451515007896 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 451515007897 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 451515007898 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 451515007899 Flavodoxin; Region: Flavodoxin_1; pfam00258 451515007900 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 451515007901 FAD binding pocket [chemical binding]; other site 451515007902 FAD binding motif [chemical binding]; other site 451515007903 catalytic residues [active] 451515007904 NAD binding pocket [chemical binding]; other site 451515007905 phosphate binding motif [ion binding]; other site 451515007906 beta-alpha-beta structure motif; other site 451515007907 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 451515007908 catalytic residues [active] 451515007909 dimer interface [polypeptide binding]; other site 451515007910 FtsX-like permease family; Region: FtsX; pfam02687 451515007911 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 451515007912 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 451515007913 Walker A/P-loop; other site 451515007914 ATP binding site [chemical binding]; other site 451515007915 Q-loop/lid; other site 451515007916 ABC transporter signature motif; other site 451515007917 Walker B; other site 451515007918 D-loop; other site 451515007919 H-loop/switch region; other site 451515007920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 451515007921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 451515007922 ATP binding site [chemical binding]; other site 451515007923 Mg2+ binding site [ion binding]; other site 451515007924 G-X-G motif; other site 451515007925 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 451515007926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 451515007927 active site 451515007928 phosphorylation site [posttranslational modification] 451515007929 intermolecular recognition site; other site 451515007930 dimerization interface [polypeptide binding]; other site 451515007931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 451515007932 DNA binding site [nucleotide binding] 451515007933 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 451515007934 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 451515007935 dimer interface [polypeptide binding]; other site 451515007936 active site 451515007937 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 451515007938 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 451515007939 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 451515007940 MarR family; Region: MarR_2; pfam12802 451515007941 Predicted esterase [General function prediction only]; Region: COG0627 451515007942 S-formylglutathione hydrolase; Region: PLN02442 451515007943 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 451515007944 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 451515007945 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 451515007946 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 451515007947 ligand binding site [chemical binding]; other site 451515007948 flexible hinge region; other site 451515007949 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 451515007950 carbamate kinase; Reviewed; Region: PRK12686 451515007951 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 451515007952 putative substrate binding site [chemical binding]; other site 451515007953 nucleotide binding site [chemical binding]; other site 451515007954 nucleotide binding site [chemical binding]; other site 451515007955 homodimer interface [polypeptide binding]; other site 451515007956 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 451515007957 ornithine carbamoyltransferase; Validated; Region: PRK02102 451515007958 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 451515007959 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 451515007960 arginine deiminase; Provisional; Region: PRK01388 451515007961 Arginine repressor [Transcription]; Region: ArgR; COG1438 451515007962 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 451515007963 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 451515007964 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 451515007965 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 451515007966 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 451515007967 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 451515007968 active site 451515007969 Zn binding site [ion binding]; other site 451515007970 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 451515007971 HTH domain; Region: HTH_11; pfam08279 451515007972 PRD domain; Region: PRD; pfam00874 451515007973 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 451515007974 active site 451515007975 P-loop; other site 451515007976 phosphorylation site [posttranslational modification] 451515007977 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 451515007978 active site 451515007979 phosphorylation site [posttranslational modification] 451515007980 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 451515007981 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 451515007982 active site 451515007983 P-loop; other site 451515007984 phosphorylation site [posttranslational modification] 451515007985 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 451515007986 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 451515007987 active site 451515007988 phosphorylation site [posttranslational modification] 451515007989 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 451515007990 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 451515007991 Predicted membrane protein [Function unknown]; Region: COG1511 451515007992 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 451515007993 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 451515007994 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 451515007995 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 451515007996 CHAP domain; Region: CHAP; pfam05257 451515007997 Isochorismatase family; Region: Isochorismatase; pfam00857 451515007998 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 451515007999 catalytic triad [active] 451515008000 conserved cis-peptide bond; other site 451515008001 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 451515008002 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 451515008003 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 451515008004 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 451515008005 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 451515008006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 451515008007 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 451515008008 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 451515008009 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 451515008010 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 451515008011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 451515008012 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 451515008013 SecY translocase; Region: SecY; pfam00344 451515008014 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 451515008015 legume lectins; Region: lectin_L-type; cd01951 451515008016 homotetramer interaction site [polypeptide binding]; other site 451515008017 carbohydrate binding site [chemical binding]; other site 451515008018 metal binding site [ion binding]; metal-binding site 451515008019 Putative Ig domain; Region: He_PIG; pfam05345 451515008020 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 451515008021 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 451515008022 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 451515008023 methionine sulfoxide reductase A; Provisional; Region: PRK05528 451515008024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 451515008025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 451515008026 Coenzyme A binding pocket [chemical binding]; other site 451515008027 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 451515008028 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 451515008029 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 451515008030 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 451515008031 Chain length determinant protein; Region: Wzz; cl15801 451515008032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 451515008033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 451515008034 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 451515008035 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 451515008036 DXD motif; other site 451515008037 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 451515008038 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 451515008039 Acyltransferase family; Region: Acyl_transf_3; pfam01757 451515008040 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 451515008041 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 451515008042 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 451515008043 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 451515008044 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 451515008045 metal binding site [ion binding]; metal-binding site 451515008046 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 451515008047 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 451515008048 substrate binding site [chemical binding]; other site 451515008049 glutamase interaction surface [polypeptide binding]; other site 451515008050 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 451515008051 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 451515008052 catalytic residues [active] 451515008053 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 451515008054 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 451515008055 putative active site [active] 451515008056 oxyanion strand; other site 451515008057 catalytic triad [active] 451515008058 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 451515008059 putative active site pocket [active] 451515008060 4-fold oligomerization interface [polypeptide binding]; other site 451515008061 metal binding residues [ion binding]; metal-binding site 451515008062 3-fold/trimer interface [polypeptide binding]; other site 451515008063 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 451515008064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 451515008065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 451515008066 homodimer interface [polypeptide binding]; other site 451515008067 catalytic residue [active] 451515008068 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 451515008069 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 451515008070 NAD binding site [chemical binding]; other site 451515008071 dimerization interface [polypeptide binding]; other site 451515008072 product binding site; other site 451515008073 substrate binding site [chemical binding]; other site 451515008074 zinc binding site [ion binding]; other site 451515008075 catalytic residues [active] 451515008076 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 451515008077 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 451515008078 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 451515008079 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 451515008080 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 451515008081 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 451515008082 putative active site [active] 451515008083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 451515008084 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 451515008085 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 451515008086 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 451515008087 Walker A/P-loop; other site 451515008088 ATP binding site [chemical binding]; other site 451515008089 Q-loop/lid; other site 451515008090 ABC transporter signature motif; other site 451515008091 Walker B; other site 451515008092 D-loop; other site 451515008093 H-loop/switch region; other site 451515008094 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 451515008095 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 451515008096 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 451515008097 Walker A/P-loop; other site 451515008098 ATP binding site [chemical binding]; other site 451515008099 Q-loop/lid; other site 451515008100 ABC transporter signature motif; other site 451515008101 Walker B; other site 451515008102 D-loop; other site 451515008103 H-loop/switch region; other site 451515008104 hypothetical protein; Provisional; Region: PRK13661 451515008105 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 451515008106 Uncharacterized conserved protein [Function unknown]; Region: COG1912 451515008107 Uncharacterized conserved protein [Function unknown]; Region: COG2353 451515008108 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 451515008109 Strictosidine synthase; Region: Str_synth; pfam03088 451515008110 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 451515008111 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 451515008112 active site residue [active] 451515008113 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 451515008114 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 451515008115 putative substrate binding pocket [chemical binding]; other site 451515008116 AC domain interface; other site 451515008117 catalytic triad [active] 451515008118 AB domain interface; other site 451515008119 interchain disulfide; other site 451515008120 hypothetical protein; Validated; Region: PRK07668 451515008121 Predicted transcriptional regulators [Transcription]; Region: COG1695 451515008122 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 451515008123 DinB superfamily; Region: DinB_2; pfam12867 451515008124 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 451515008125 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 451515008126 transmembrane helices; other site 451515008127 Predicted permeases [General function prediction only]; Region: RarD; COG2962 451515008128 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 451515008129 hypothetical protein; Provisional; Region: PRK07758 451515008130 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 451515008131 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 451515008132 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 451515008133 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 451515008134 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 451515008135 Walker A/P-loop; other site 451515008136 ATP binding site [chemical binding]; other site 451515008137 Q-loop/lid; other site 451515008138 ABC transporter signature motif; other site 451515008139 Walker B; other site 451515008140 D-loop; other site 451515008141 H-loop/switch region; other site 451515008142 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 451515008143 FtsX-like permease family; Region: FtsX; pfam02687 451515008144 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 451515008145 Integrase core domain; Region: rve; pfam00665 451515008146 Integrase core domain; Region: rve_3; cl15866 451515008147 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 451515008148 DNA-binding site [nucleotide binding]; DNA binding site 451515008149 RNA-binding motif; other site 451515008150 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 451515008151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 451515008152 non-specific DNA binding site [nucleotide binding]; other site 451515008153 salt bridge; other site 451515008154 sequence-specific DNA binding site [nucleotide binding]; other site 451515008155 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 451515008156 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 451515008157 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 451515008158 ParB-like nuclease domain; Region: ParBc; pfam02195 451515008159 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 451515008160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 451515008161 S-adenosylmethionine binding site [chemical binding]; other site 451515008162 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 451515008163 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 451515008164 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 451515008165 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 451515008166 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 451515008167 trmE is a tRNA modification GTPase; Region: trmE; cd04164 451515008168 G1 box; other site 451515008169 GTP/Mg2+ binding site [chemical binding]; other site 451515008170 Switch I region; other site 451515008171 G2 box; other site 451515008172 Switch II region; other site 451515008173 G3 box; other site 451515008174 G4 box; other site 451515008175 G5 box; other site 451515008176 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 451515008177 ribonuclease P; Reviewed; Region: rnpA; PRK00499 451515008178 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399