-- dump date   	20140620_075628
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1028799000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1028799000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1028799000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799000004	Walker A motif; other site
1028799000005	ATP binding site [chemical binding]; other site
1028799000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1028799000007	Walker B motif; other site
1028799000008	arginine finger; other site
1028799000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1028799000010	DnaA box-binding interface [nucleotide binding]; other site
1028799000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
1028799000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1028799000013	putative DNA binding surface [nucleotide binding]; other site
1028799000014	dimer interface [polypeptide binding]; other site
1028799000015	beta-clamp/clamp loader binding surface; other site
1028799000016	beta-clamp/translesion DNA polymerase binding surface; other site
1028799000017	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1028799000018	recF protein; Region: recf; TIGR00611
1028799000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1028799000020	Walker A/P-loop; other site
1028799000021	ATP binding site [chemical binding]; other site
1028799000022	Q-loop/lid; other site
1028799000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799000024	ABC transporter signature motif; other site
1028799000025	Walker B; other site
1028799000026	D-loop; other site
1028799000027	H-loop/switch region; other site
1028799000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1028799000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799000030	Mg2+ binding site [ion binding]; other site
1028799000031	G-X-G motif; other site
1028799000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1028799000033	anchoring element; other site
1028799000034	dimer interface [polypeptide binding]; other site
1028799000035	ATP binding site [chemical binding]; other site
1028799000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1028799000037	active site
1028799000038	putative metal-binding site [ion binding]; other site
1028799000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1028799000040	DNA gyrase subunit A; Validated; Region: PRK05560
1028799000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1028799000042	CAP-like domain; other site
1028799000043	active site
1028799000044	primary dimer interface [polypeptide binding]; other site
1028799000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1028799000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1028799000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1028799000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1028799000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1028799000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1028799000051	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1028799000052	putative substrate binding site [chemical binding]; other site
1028799000053	putative ATP binding site [chemical binding]; other site
1028799000054	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1028799000055	active sites [active]
1028799000056	tetramer interface [polypeptide binding]; other site
1028799000057	seryl-tRNA synthetase; Provisional; Region: PRK05431
1028799000058	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1028799000059	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1028799000060	dimer interface [polypeptide binding]; other site
1028799000061	active site
1028799000062	motif 1; other site
1028799000063	motif 2; other site
1028799000064	motif 3; other site
1028799000065	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1028799000066	Predicted membrane protein [Function unknown]; Region: COG4392
1028799000067	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1028799000068	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1028799000069	Predicted membrane protein [Function unknown]; Region: COG4241
1028799000070	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1028799000071	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1028799000072	DHH family; Region: DHH; pfam01368
1028799000073	DHHA1 domain; Region: DHHA1; pfam02272
1028799000074	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1028799000075	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1028799000076	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1028799000077	replicative DNA helicase; Region: DnaB; TIGR00665
1028799000078	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1028799000079	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1028799000080	Walker A motif; other site
1028799000081	ATP binding site [chemical binding]; other site
1028799000082	Walker B motif; other site
1028799000083	DNA binding loops [nucleotide binding]
1028799000084	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1028799000085	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1028799000086	GDP-binding site [chemical binding]; other site
1028799000087	ACT binding site; other site
1028799000088	IMP binding site; other site
1028799000089	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1028799000090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799000091	active site
1028799000092	phosphorylation site [posttranslational modification]
1028799000093	intermolecular recognition site; other site
1028799000094	dimerization interface [polypeptide binding]; other site
1028799000095	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1028799000096	DNA binding site [nucleotide binding]
1028799000097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1028799000098	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1028799000099	dimerization interface [polypeptide binding]; other site
1028799000100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1028799000101	putative active site [active]
1028799000102	heme pocket [chemical binding]; other site
1028799000103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1028799000104	dimer interface [polypeptide binding]; other site
1028799000105	phosphorylation site [posttranslational modification]
1028799000106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799000107	ATP binding site [chemical binding]; other site
1028799000108	Mg2+ binding site [ion binding]; other site
1028799000109	G-X-G motif; other site
1028799000110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1028799000111	YycH protein; Region: YycH; pfam07435
1028799000112	YycH protein; Region: YycI; cl02015
1028799000113	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1028799000114	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1028799000115	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
1028799000116	putative active site [active]
1028799000117	putative metal binding site [ion binding]; other site
1028799000118	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1028799000119	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1028799000120	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
1028799000121	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1028799000122	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1028799000123	phosphate binding site [ion binding]; other site
1028799000124	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1028799000125	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1028799000126	putative homodimer interface [polypeptide binding]; other site
1028799000127	putative homotetramer interface [polypeptide binding]; other site
1028799000128	putative metal binding site [ion binding]; other site
1028799000129	putative homodimer-homodimer interface [polypeptide binding]; other site
1028799000130	putative allosteric switch controlling residues; other site
1028799000131	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1028799000132	active site residue [active]
1028799000133	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
1028799000134	CPxP  motif; other site
1028799000135	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1028799000136	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1028799000137	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1028799000138	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1028799000139	active site residue [active]
1028799000140	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1028799000141	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1028799000142	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1028799000143	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1028799000144	FMN binding site [chemical binding]; other site
1028799000145	active site
1028799000146	catalytic residues [active]
1028799000147	substrate binding site [chemical binding]; other site
1028799000148	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
1028799000149	H+ Antiporter protein; Region: 2A0121; TIGR00900
1028799000150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799000151	putative substrate translocation pore; other site
1028799000152	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1028799000153	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1028799000154	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1028799000155	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1028799000156	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1028799000157	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1028799000158	dimerization interface [polypeptide binding]; other site
1028799000159	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1028799000160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1028799000161	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1028799000162	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1028799000163	Part of AAA domain; Region: AAA_19; pfam13245
1028799000164	AAA domain; Region: AAA_12; pfam13087
1028799000165	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1028799000166	active site
1028799000167	catalytic site [active]
1028799000168	putative metal binding site [ion binding]; other site
1028799000169	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799000170	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799000171	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799000172	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799000173	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1028799000174	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1028799000175	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1028799000176	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1028799000177	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1028799000178	metal binding site [ion binding]; metal-binding site
1028799000179	dimer interface [polypeptide binding]; other site
1028799000180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799000181	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799000182	putative substrate translocation pore; other site
1028799000183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799000184	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1028799000185	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1028799000186	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1028799000187	PhoU domain; Region: PhoU; pfam01895
1028799000188	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
1028799000189	EamA-like transporter family; Region: EamA; pfam00892
1028799000190	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1028799000191	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1028799000192	DNA-binding site [nucleotide binding]; DNA binding site
1028799000193	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1028799000194	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799000195	homodimer interface [polypeptide binding]; other site
1028799000196	catalytic residue [active]
1028799000197	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1028799000198	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1028799000199	L-lactate permease; Region: Lactate_perm; cl00701
1028799000200	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799000201	B domain; Region: B; pfam02216
1028799000202	B domain; Region: B; pfam02216
1028799000203	B domain; Region: B; pfam02216
1028799000204	B domain; Region: B; pfam02216
1028799000205	B domain; Region: B; pfam02216
1028799000206	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1028799000207	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799000208	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1028799000209	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799000210	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1028799000211	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1028799000212	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799000213	ABC-ATPase subunit  interface; other site
1028799000214	dimer interface [polypeptide binding]; other site
1028799000215	putative PBP binding regions; other site
1028799000216	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1028799000217	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799000218	ABC-ATPase subunit  interface; other site
1028799000219	dimer interface [polypeptide binding]; other site
1028799000220	putative PBP binding regions; other site
1028799000221	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1028799000222	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1028799000223	siderophore binding site; other site
1028799000224	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
1028799000225	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1028799000226	dimer interface [polypeptide binding]; other site
1028799000227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799000228	catalytic residue [active]
1028799000229	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
1028799000230	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1028799000231	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1028799000232	IucA / IucC family; Region: IucA_IucC; pfam04183
1028799000233	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1028799000234	drug efflux system protein MdtG; Provisional; Region: PRK09874
1028799000235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799000236	putative substrate translocation pore; other site
1028799000237	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1028799000238	IucA / IucC family; Region: IucA_IucC; pfam04183
1028799000239	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1028799000240	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1028799000241	IucA / IucC family; Region: IucA_IucC; pfam04183
1028799000242	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1028799000243	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1028799000244	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1028799000245	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
1028799000246	dimer interface [polypeptide binding]; other site
1028799000247	active site
1028799000248	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1028799000249	catalytic residues [active]
1028799000250	substrate binding site [chemical binding]; other site
1028799000251	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1028799000252	ParB-like nuclease domain; Region: ParBc; pfam02195
1028799000253	acetoin reductase; Validated; Region: PRK08643
1028799000254	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1028799000255	NAD binding site [chemical binding]; other site
1028799000256	homotetramer interface [polypeptide binding]; other site
1028799000257	homodimer interface [polypeptide binding]; other site
1028799000258	active site
1028799000259	substrate binding site [chemical binding]; other site
1028799000260	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1028799000261	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1028799000262	NAD(P) binding site [chemical binding]; other site
1028799000263	active site
1028799000264	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1028799000265	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1028799000266	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1028799000267	putative ADP-binding pocket [chemical binding]; other site
1028799000268	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1028799000269	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1028799000270	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1028799000271	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1028799000272	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1028799000273	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1028799000274	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1028799000275	DNA-binding site [nucleotide binding]; DNA binding site
1028799000276	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1028799000277	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1028799000278	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799000279	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1028799000280	intersubunit interface [polypeptide binding]; other site
1028799000281	active site
1028799000282	catalytic residue [active]
1028799000283	phosphopentomutase; Provisional; Region: PRK05362
1028799000284	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1028799000285	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1028799000286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799000287	dimer interface [polypeptide binding]; other site
1028799000288	conserved gate region; other site
1028799000289	putative PBP binding loops; other site
1028799000290	ABC-ATPase subunit interface; other site
1028799000291	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1028799000292	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799000293	dimer interface [polypeptide binding]; other site
1028799000294	conserved gate region; other site
1028799000295	ABC-ATPase subunit interface; other site
1028799000296	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1028799000297	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1028799000298	Walker A/P-loop; other site
1028799000299	ATP binding site [chemical binding]; other site
1028799000300	Q-loop/lid; other site
1028799000301	ABC transporter signature motif; other site
1028799000302	Walker B; other site
1028799000303	D-loop; other site
1028799000304	H-loop/switch region; other site
1028799000305	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1028799000306	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1028799000307	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1028799000308	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1028799000309	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1028799000310	active site
1028799000311	metal binding site [ion binding]; metal-binding site
1028799000312	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1028799000313	Replication initiation factor; Region: Rep_trans; pfam02486
1028799000314	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799000315	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799000316	Transposase IS200 like; Region: Y1_Tnp; cl00848
1028799000317	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1028799000318	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1028799000319	putative catalytic cysteine [active]
1028799000320	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1028799000321	putative active site [active]
1028799000322	metal binding site [ion binding]; metal-binding site
1028799000323	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1028799000324	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
1028799000325	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1028799000326	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1028799000327	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1028799000328	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1028799000329	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1028799000330	NAD(P) binding site [chemical binding]; other site
1028799000331	homodimer interface [polypeptide binding]; other site
1028799000332	substrate binding site [chemical binding]; other site
1028799000333	active site
1028799000334	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
1028799000335	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1028799000336	NAD(P) binding site [chemical binding]; other site
1028799000337	homodimer interface [polypeptide binding]; other site
1028799000338	substrate binding site [chemical binding]; other site
1028799000339	active site
1028799000340	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
1028799000341	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
1028799000342	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1028799000343	putative NAD(P) binding site [chemical binding]; other site
1028799000344	active site
1028799000345	putative substrate binding site [chemical binding]; other site
1028799000346	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1028799000347	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1028799000348	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1028799000349	active site
1028799000350	homodimer interface [polypeptide binding]; other site
1028799000351	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1028799000352	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1028799000353	trimer interface [polypeptide binding]; other site
1028799000354	active site
1028799000355	substrate binding site [chemical binding]; other site
1028799000356	CoA binding site [chemical binding]; other site
1028799000357	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1028799000358	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1028799000359	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1028799000360	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1028799000361	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1028799000362	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1028799000363	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
1028799000364	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1028799000365	putative NAD(P) binding site [chemical binding]; other site
1028799000366	active site
1028799000367	putative substrate binding site [chemical binding]; other site
1028799000368	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1028799000369	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1028799000370	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1028799000371	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1028799000372	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1028799000373	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1028799000374	active site
1028799000375	homodimer interface [polypeptide binding]; other site
1028799000376	heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313
1028799000377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1028799000378	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
1028799000379	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1028799000380	NAD(P) binding site [chemical binding]; other site
1028799000381	catalytic residues [active]
1028799000382	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1028799000383	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1028799000384	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
1028799000385	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1028799000386	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1028799000387	Walker A/P-loop; other site
1028799000388	ATP binding site [chemical binding]; other site
1028799000389	Q-loop/lid; other site
1028799000390	ABC transporter signature motif; other site
1028799000391	Walker B; other site
1028799000392	D-loop; other site
1028799000393	H-loop/switch region; other site
1028799000394	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1028799000395	NMT1-like family; Region: NMT1_2; pfam13379
1028799000396	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1028799000397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1028799000398	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1028799000399	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1028799000400	active site
1028799000401	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1028799000402	formate dehydrogenase; Provisional; Region: PRK07574
1028799000403	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
1028799000404	dimerization interface [polypeptide binding]; other site
1028799000405	ligand binding site [chemical binding]; other site
1028799000406	NAD binding site [chemical binding]; other site
1028799000407	catalytic site [active]
1028799000408	putative transporter; Provisional; Region: PRK10054
1028799000409	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1028799000410	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1028799000411	acyl-activating enzyme (AAE) consensus motif; other site
1028799000412	AMP binding site [chemical binding]; other site
1028799000413	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1028799000414	Condensation domain; Region: Condensation; pfam00668
1028799000415	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1028799000416	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1028799000417	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1028799000418	acyl-activating enzyme (AAE) consensus motif; other site
1028799000419	AMP binding site [chemical binding]; other site
1028799000420	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1028799000421	thioester reductase domain; Region: Thioester-redct; TIGR01746
1028799000422	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1028799000423	NAD(P) binding site [chemical binding]; other site
1028799000424	active site
1028799000425	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1028799000426	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1028799000427	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
1028799000428	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1028799000429	nucleotide binding site [chemical binding]; other site
1028799000430	N-acetyl-L-glutamate binding site [chemical binding]; other site
1028799000431	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1028799000432	heterotetramer interface [polypeptide binding]; other site
1028799000433	active site pocket [active]
1028799000434	cleavage site
1028799000435	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1028799000436	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1028799000437	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1028799000438	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1028799000439	inhibitor-cofactor binding pocket; inhibition site
1028799000440	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799000441	catalytic residue [active]
1028799000442	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1028799000443	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1028799000444	Isochorismatase family; Region: Isochorismatase; pfam00857
1028799000445	catalytic triad [active]
1028799000446	conserved cis-peptide bond; other site
1028799000447	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1028799000448	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1028799000449	dimer interface [polypeptide binding]; other site
1028799000450	PYR/PP interface [polypeptide binding]; other site
1028799000451	TPP binding site [chemical binding]; other site
1028799000452	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1028799000453	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1028799000454	TPP-binding site [chemical binding]; other site
1028799000455	dimer interface [polypeptide binding]; other site
1028799000456	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1028799000457	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1028799000458	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1028799000459	active site turn [active]
1028799000460	phosphorylation site [posttranslational modification]
1028799000461	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1028799000462	HPr interaction site; other site
1028799000463	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1028799000464	active site
1028799000465	phosphorylation site [posttranslational modification]
1028799000466	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1028799000467	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1028799000468	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
1028799000469	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1028799000470	putative active site [active]
1028799000471	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1028799000472	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1028799000473	active site turn [active]
1028799000474	phosphorylation site [posttranslational modification]
1028799000475	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1028799000476	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1028799000477	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1028799000478	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1028799000479	putative active site [active]
1028799000480	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1028799000481	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1028799000482	RES domain; Region: RES; pfam08808
1028799000483	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1028799000484	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799000485	Walker A/P-loop; other site
1028799000486	ATP binding site [chemical binding]; other site
1028799000487	Q-loop/lid; other site
1028799000488	ABC transporter signature motif; other site
1028799000489	Walker B; other site
1028799000490	D-loop; other site
1028799000491	H-loop/switch region; other site
1028799000492	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1028799000493	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799000494	Walker A/P-loop; other site
1028799000495	ATP binding site [chemical binding]; other site
1028799000496	Q-loop/lid; other site
1028799000497	ABC transporter signature motif; other site
1028799000498	Walker B; other site
1028799000499	D-loop; other site
1028799000500	H-loop/switch region; other site
1028799000501	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1028799000502	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799000503	dimer interface [polypeptide binding]; other site
1028799000504	conserved gate region; other site
1028799000505	putative PBP binding loops; other site
1028799000506	ABC-ATPase subunit interface; other site
1028799000507	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1028799000508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799000509	dimer interface [polypeptide binding]; other site
1028799000510	conserved gate region; other site
1028799000511	ABC-ATPase subunit interface; other site
1028799000512	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1028799000513	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1028799000514	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1028799000515	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1028799000516	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1028799000517	Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742
1028799000518	azoreductase; Reviewed; Region: PRK00170
1028799000519	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1028799000520	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1028799000521	Peptidase family M23; Region: Peptidase_M23; pfam01551
1028799000522	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1028799000523	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1028799000524	Walker A/P-loop; other site
1028799000525	ATP binding site [chemical binding]; other site
1028799000526	Q-loop/lid; other site
1028799000527	ABC transporter signature motif; other site
1028799000528	Walker B; other site
1028799000529	D-loop; other site
1028799000530	H-loop/switch region; other site
1028799000531	TOBE domain; Region: TOBE; pfam03459
1028799000532	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1028799000533	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1028799000534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799000535	dimer interface [polypeptide binding]; other site
1028799000536	conserved gate region; other site
1028799000537	ABC-ATPase subunit interface; other site
1028799000538	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1028799000539	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799000540	dimer interface [polypeptide binding]; other site
1028799000541	conserved gate region; other site
1028799000542	putative PBP binding loops; other site
1028799000543	ABC-ATPase subunit interface; other site
1028799000544	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1028799000545	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1028799000546	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1028799000547	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1028799000548	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1028799000549	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1028799000550	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1028799000551	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1028799000552	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1028799000553	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1028799000554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799000555	putative substrate translocation pore; other site
1028799000556	Response regulator receiver domain; Region: Response_reg; pfam00072
1028799000557	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799000558	active site
1028799000559	phosphorylation site [posttranslational modification]
1028799000560	intermolecular recognition site; other site
1028799000561	dimerization interface [polypeptide binding]; other site
1028799000562	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1028799000563	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1028799000564	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1028799000565	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1028799000566	Histidine kinase; Region: His_kinase; pfam06580
1028799000567	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799000568	ATP binding site [chemical binding]; other site
1028799000569	Mg2+ binding site [ion binding]; other site
1028799000570	G-X-G motif; other site
1028799000571	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1028799000572	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1028799000573	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1028799000574	Pyruvate formate lyase 1; Region: PFL1; cd01678
1028799000575	coenzyme A binding site [chemical binding]; other site
1028799000576	active site
1028799000577	catalytic residues [active]
1028799000578	glycine loop; other site
1028799000579	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1028799000580	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799000581	FeS/SAM binding site; other site
1028799000582	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1028799000583	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
1028799000584	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1028799000585	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1028799000586	putative active site [active]
1028799000587	catalytic site [active]
1028799000588	putative metal binding site [ion binding]; other site
1028799000589	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1028799000590	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1028799000591	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1028799000592	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1028799000593	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1028799000594	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1028799000595	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1028799000596	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1028799000597	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1028799000598	dimer interface [polypeptide binding]; other site
1028799000599	active site
1028799000600	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1028799000601	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1028799000602	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1028799000603	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1028799000604	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1028799000605	substrate binding site [chemical binding]; other site
1028799000606	oxyanion hole (OAH) forming residues; other site
1028799000607	trimer interface [polypeptide binding]; other site
1028799000608	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1028799000609	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1028799000610	active site
1028799000611	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1028799000612	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1028799000613	acyl-activating enzyme (AAE) consensus motif; other site
1028799000614	AMP binding site [chemical binding]; other site
1028799000615	active site
1028799000616	CoA binding site [chemical binding]; other site
1028799000617	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1028799000618	Coenzyme A transferase; Region: CoA_trans; smart00882
1028799000619	Coenzyme A transferase; Region: CoA_trans; cl17247
1028799000620	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1028799000621	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1028799000622	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1028799000623	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1028799000624	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1028799000625	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1028799000626	heme-binding site [chemical binding]; other site
1028799000627	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1028799000628	FAD binding pocket [chemical binding]; other site
1028799000629	FAD binding motif [chemical binding]; other site
1028799000630	phosphate binding motif [ion binding]; other site
1028799000631	beta-alpha-beta structure motif; other site
1028799000632	NAD binding pocket [chemical binding]; other site
1028799000633	Heme binding  pocket [chemical binding]; other site
1028799000634	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1028799000635	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1028799000636	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1028799000637	NAD binding site [chemical binding]; other site
1028799000638	dimer interface [polypeptide binding]; other site
1028799000639	substrate binding site [chemical binding]; other site
1028799000640	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1028799000641	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1028799000642	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1028799000643	active site turn [active]
1028799000644	phosphorylation site [posttranslational modification]
1028799000645	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1028799000646	active site
1028799000647	tetramer interface [polypeptide binding]; other site
1028799000648	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1028799000649	Mga helix-turn-helix domain; Region: Mga; pfam05043
1028799000650	PRD domain; Region: PRD; pfam00874
1028799000651	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1028799000652	active site
1028799000653	P-loop; other site
1028799000654	phosphorylation site [posttranslational modification]
1028799000655	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1028799000656	active site
1028799000657	phosphorylation site [posttranslational modification]
1028799000658	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1028799000659	active site
1028799000660	phosphorylation site [posttranslational modification]
1028799000661	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1028799000662	active site
1028799000663	P-loop; other site
1028799000664	phosphorylation site [posttranslational modification]
1028799000665	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1028799000666	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1028799000667	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1028799000668	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
1028799000669	putative NAD(P) binding site [chemical binding]; other site
1028799000670	catalytic Zn binding site [ion binding]; other site
1028799000671	structural Zn binding site [ion binding]; other site
1028799000672	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1028799000673	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
1028799000674	putative NAD(P) binding site [chemical binding]; other site
1028799000675	catalytic Zn binding site [ion binding]; other site
1028799000676	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1028799000677	substrate binding site; other site
1028799000678	dimer interface; other site
1028799000679	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
1028799000680	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1028799000681	putative NAD(P) binding site [chemical binding]; other site
1028799000682	putative catalytic Zn binding site [ion binding]; other site
1028799000683	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1028799000684	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1028799000685	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1028799000686	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1028799000687	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1028799000688	substrate binding site; other site
1028799000689	dimer interface; other site
1028799000690	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
1028799000691	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1028799000692	putative NAD(P) binding site [chemical binding]; other site
1028799000693	putative catalytic Zn binding site [ion binding]; other site
1028799000694	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1028799000695	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1028799000696	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1028799000697	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1028799000698	active site
1028799000699	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
1028799000700	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1028799000701	Hemerythrin-like domain; Region: Hr-like; cd12108
1028799000702	Fe binding site [ion binding]; other site
1028799000703	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1028799000704	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1028799000705	Histidine kinase; Region: His_kinase; pfam06580
1028799000706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799000707	Mg2+ binding site [ion binding]; other site
1028799000708	G-X-G motif; other site
1028799000709	two-component response regulator; Provisional; Region: PRK14084
1028799000710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799000711	active site
1028799000712	phosphorylation site [posttranslational modification]
1028799000713	intermolecular recognition site; other site
1028799000714	dimerization interface [polypeptide binding]; other site
1028799000715	LytTr DNA-binding domain; Region: LytTR; pfam04397
1028799000716	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
1028799000717	antiholin-like protein LrgB; Provisional; Region: PRK04288
1028799000718	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1028799000719	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1028799000720	DNA-binding site [nucleotide binding]; DNA binding site
1028799000721	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1028799000722	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1028799000723	active site turn [active]
1028799000724	phosphorylation site [posttranslational modification]
1028799000725	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1028799000726	HPr interaction site; other site
1028799000727	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1028799000728	active site
1028799000729	phosphorylation site [posttranslational modification]
1028799000730	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1028799000731	beta-galactosidase; Region: BGL; TIGR03356
1028799000732	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1028799000733	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799000734	S-adenosylmethionine binding site [chemical binding]; other site
1028799000735	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1028799000736	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1028799000737	substrate binding site [chemical binding]; other site
1028799000738	dimer interface [polypeptide binding]; other site
1028799000739	ATP binding site [chemical binding]; other site
1028799000740	D-ribose pyranase; Provisional; Region: PRK11797
1028799000741	Sugar transport protein; Region: Sugar_transport; pfam06800
1028799000742	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1028799000743	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1028799000744	DNA binding site [nucleotide binding]
1028799000745	domain linker motif; other site
1028799000746	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1028799000747	dimerization interface [polypeptide binding]; other site
1028799000748	ligand binding site [chemical binding]; other site
1028799000749	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1028799000750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799000751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799000752	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1028799000753	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1028799000754	active site
1028799000755	Surface antigen [General function prediction only]; Region: COG3942
1028799000756	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1028799000757	Peptidase family M23; Region: Peptidase_M23; pfam01551
1028799000758	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1028799000759	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1028799000760	Walker A/P-loop; other site
1028799000761	ATP binding site [chemical binding]; other site
1028799000762	Q-loop/lid; other site
1028799000763	ABC transporter signature motif; other site
1028799000764	Walker B; other site
1028799000765	D-loop; other site
1028799000766	H-loop/switch region; other site
1028799000767	Surface antigen [General function prediction only]; Region: COG3942
1028799000768	CHAP domain; Region: CHAP; pfam05257
1028799000769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1028799000770	Predicted membrane protein [Function unknown]; Region: COG1511
1028799000771	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1028799000772	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1028799000773	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
1028799000774	Uncharacterized small protein [Function unknown]; Region: COG5417
1028799000775	Predicted membrane protein [Function unknown]; Region: COG4499
1028799000776	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1028799000777	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1028799000778	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1028799000779	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1028799000780	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1028799000781	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1028799000782	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1028799000783	Uncharacterized conserved protein [Function unknown]; Region: COG5444
1028799000784	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1028799000785	Protein of unknown function, DUF600; Region: DUF600; cl04640
1028799000786	Protein of unknown function, DUF600; Region: DUF600; cl04640
1028799000787	Protein of unknown function, DUF600; Region: DUF600; cl04640
1028799000788	Protein of unknown function, DUF600; Region: DUF600; cl04640
1028799000789	Protein of unknown function, DUF600; Region: DUF600; cl04640
1028799000790	conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741
1028799000791	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1028799000792	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1028799000793	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1028799000794	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
1028799000795	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1028799000796	FtsX-like permease family; Region: FtsX; pfam02687
1028799000797	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1028799000798	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1028799000799	Walker A/P-loop; other site
1028799000800	ATP binding site [chemical binding]; other site
1028799000801	Q-loop/lid; other site
1028799000802	ABC transporter signature motif; other site
1028799000803	Walker B; other site
1028799000804	D-loop; other site
1028799000805	H-loop/switch region; other site
1028799000806	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1028799000807	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1028799000808	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1028799000809	non-specific DNA binding site [nucleotide binding]; other site
1028799000810	salt bridge; other site
1028799000811	sequence-specific DNA binding site [nucleotide binding]; other site
1028799000812	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1028799000813	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1028799000814	substrate binding site [chemical binding]; other site
1028799000815	ATP binding site [chemical binding]; other site
1028799000816	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
1028799000817	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1028799000818	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1028799000819	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1028799000820	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
1028799000821	putative transporter; Provisional; Region: PRK10484
1028799000822	Na binding site [ion binding]; other site
1028799000823	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1028799000824	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1028799000825	inhibitor site; inhibition site
1028799000826	active site
1028799000827	dimer interface [polypeptide binding]; other site
1028799000828	catalytic residue [active]
1028799000829	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1028799000830	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1028799000831	nucleotide binding site [chemical binding]; other site
1028799000832	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1028799000833	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1028799000834	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1028799000835	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1028799000836	putative active site [active]
1028799000837	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1028799000838	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1028799000839	putative active site cavity [active]
1028799000840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1028799000841	Nucleoside recognition; Region: Gate; pfam07670
1028799000842	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1028799000843	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1028799000844	PGAP1-like protein; Region: PGAP1; pfam07819
1028799000845	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1028799000846	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1028799000847	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1028799000848	putative active site [active]
1028799000849	putative FMN binding site [chemical binding]; other site
1028799000850	putative substrate binding site [chemical binding]; other site
1028799000851	putative catalytic residue [active]
1028799000852	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1028799000853	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1028799000854	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1028799000855	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1028799000856	lipoyl attachment site [posttranslational modification]; other site
1028799000857	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1028799000858	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
1028799000859	putative ADP-ribose binding site [chemical binding]; other site
1028799000860	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
1028799000861	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1028799000862	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1028799000863	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1028799000864	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1028799000865	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1028799000866	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
1028799000867	NADP binding site [chemical binding]; other site
1028799000868	putative substrate binding site [chemical binding]; other site
1028799000869	active site
1028799000870	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1028799000871	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1028799000872	active site
1028799000873	P-loop; other site
1028799000874	phosphorylation site [posttranslational modification]
1028799000875	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1028799000876	active site
1028799000877	phosphorylation site [posttranslational modification]
1028799000878	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1028799000879	HTH domain; Region: HTH_11; pfam08279
1028799000880	HTH domain; Region: HTH_11; pfam08279
1028799000881	PRD domain; Region: PRD; pfam00874
1028799000882	PRD domain; Region: PRD; pfam00874
1028799000883	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1028799000884	active site
1028799000885	P-loop; other site
1028799000886	phosphorylation site [posttranslational modification]
1028799000887	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1028799000888	active site
1028799000889	phosphorylation site [posttranslational modification]
1028799000890	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1028799000891	MarR family; Region: MarR_2; pfam12802
1028799000892	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1028799000893	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1028799000894	MepB protein; Region: MepB; cl01985
1028799000895	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1028799000896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799000897	putative substrate translocation pore; other site
1028799000898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799000899	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1028799000900	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1028799000901	Zn binding site [ion binding]; other site
1028799000902	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1028799000903	Zn binding site [ion binding]; other site
1028799000904	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1028799000905	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1028799000906	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1028799000907	Predicted flavoprotein [General function prediction only]; Region: COG0431
1028799000908	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1028799000909	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
1028799000910	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1028799000911	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1028799000912	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
1028799000913	Imelysin; Region: Peptidase_M75; pfam09375
1028799000914	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1028799000915	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1028799000916	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1028799000917	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1028799000918	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1028799000919	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
1028799000920	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1028799000921	non-specific DNA binding site [nucleotide binding]; other site
1028799000922	salt bridge; other site
1028799000923	sequence-specific DNA binding site [nucleotide binding]; other site
1028799000924	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
1028799000925	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1028799000926	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1028799000927	Walker A/P-loop; other site
1028799000928	ATP binding site [chemical binding]; other site
1028799000929	Q-loop/lid; other site
1028799000930	ABC transporter signature motif; other site
1028799000931	Walker B; other site
1028799000932	D-loop; other site
1028799000933	H-loop/switch region; other site
1028799000934	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1028799000935	Predicted membrane protein [Function unknown]; Region: COG4292
1028799000936	putative acyltransferase; Provisional; Region: PRK05790
1028799000937	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1028799000938	dimer interface [polypeptide binding]; other site
1028799000939	active site
1028799000940	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1028799000941	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1028799000942	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
1028799000943	THF binding site; other site
1028799000944	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1028799000945	substrate binding site [chemical binding]; other site
1028799000946	THF binding site; other site
1028799000947	zinc-binding site [ion binding]; other site
1028799000948	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1028799000949	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1028799000950	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1028799000951	FAD binding site [chemical binding]; other site
1028799000952	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1028799000953	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1028799000954	homodimer interface [polypeptide binding]; other site
1028799000955	substrate-cofactor binding pocket; other site
1028799000956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799000957	catalytic residue [active]
1028799000958	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1028799000959	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1028799000960	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1028799000961	catalytic residue [active]
1028799000962	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1028799000963	ParB-like nuclease domain; Region: ParB; smart00470
1028799000964	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1028799000965	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1028799000966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
1028799000967	GTP-binding protein YchF; Reviewed; Region: PRK09601
1028799000968	YchF GTPase; Region: YchF; cd01900
1028799000969	G1 box; other site
1028799000970	GTP/Mg2+ binding site [chemical binding]; other site
1028799000971	Switch I region; other site
1028799000972	G2 box; other site
1028799000973	Switch II region; other site
1028799000974	G3 box; other site
1028799000975	G4 box; other site
1028799000976	G5 box; other site
1028799000977	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1028799000978	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1028799000979	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1028799000980	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1028799000981	dimer interface [polypeptide binding]; other site
1028799000982	ssDNA binding site [nucleotide binding]; other site
1028799000983	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1028799000984	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1028799000985	Abi-like protein; Region: Abi_2; pfam07751
1028799000986	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1028799000987	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1028799000988	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799000989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1028799000990	Predicted membrane protein [Function unknown]; Region: COG3212
1028799000991	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1028799000992	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1028799000993	non-specific DNA binding site [nucleotide binding]; other site
1028799000994	salt bridge; other site
1028799000995	sequence-specific DNA binding site [nucleotide binding]; other site
1028799000996	Predicted membrane protein [Function unknown]; Region: COG2261
1028799000997	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1028799000998	catalytic core [active]
1028799000999	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1028799001000	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1028799001001	catalytic residue [active]
1028799001002	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1028799001003	catalytic residues [active]
1028799001004	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1028799001005	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799001006	peroxiredoxin; Region: AhpC; TIGR03137
1028799001007	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1028799001008	dimer interface [polypeptide binding]; other site
1028799001009	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1028799001010	catalytic triad [active]
1028799001011	peroxidatic and resolving cysteines [active]
1028799001012	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1028799001013	dimer interface [polypeptide binding]; other site
1028799001014	FMN binding site [chemical binding]; other site
1028799001015	NADPH bind site [chemical binding]; other site
1028799001016	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1028799001017	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1028799001018	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1028799001019	active site
1028799001020	xanthine permease; Region: pbuX; TIGR03173
1028799001021	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1028799001022	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1028799001023	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1028799001024	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1028799001025	active site
1028799001026	GMP synthase; Reviewed; Region: guaA; PRK00074
1028799001027	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1028799001028	AMP/PPi binding site [chemical binding]; other site
1028799001029	candidate oxyanion hole; other site
1028799001030	catalytic triad [active]
1028799001031	potential glutamine specificity residues [chemical binding]; other site
1028799001032	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1028799001033	ATP Binding subdomain [chemical binding]; other site
1028799001034	Ligand Binding sites [chemical binding]; other site
1028799001035	Dimerization subdomain; other site
1028799001036	PemK-like protein; Region: PemK; pfam02452
1028799001037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1028799001038	Transposase; Region: HTH_Tnp_1; cl17663
1028799001039	Predicted membrane protein [Function unknown]; Region: COG3759
1028799001040	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1028799001041	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1028799001042	NADP binding site [chemical binding]; other site
1028799001043	superantigen-like protein; Reviewed; Region: PRK13037
1028799001044	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001045	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001046	superantigen-like protein; Reviewed; Region: PRK13041
1028799001047	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001048	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001049	superantigen-like protein; Reviewed; Region: PRK13335
1028799001050	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001051	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001052	superantigen-like protein; Reviewed; Region: PRK13042
1028799001053	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001054	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001055	superantigen-like protein 5; Reviewed; Region: PRK13035
1028799001056	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001057	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001058	superantigen-like protein; Reviewed; Region: PRK13040
1028799001059	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001060	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001061	superantigen-like protein 7; Reviewed; Region: PRK13346
1028799001062	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001063	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001064	superantigen-like protein; Reviewed; Region: PRK13039
1028799001065	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001066	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001067	superantigen-like protein; Reviewed; Region: PRK13345
1028799001068	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001069	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001070	superantigen-like protein 5; Reviewed; Region: PRK13035
1028799001071	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001072	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001073	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1028799001074	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1028799001075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799001076	S-adenosylmethionine binding site [chemical binding]; other site
1028799001077	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1028799001078	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1028799001079	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1028799001080	superantigen-like protein; Reviewed; Region: PRK13036
1028799001081	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1028799001082	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799001083	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
1028799001084	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799001085	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799001086	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799001087	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1028799001088	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1028799001089	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1028799001090	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1028799001091	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1028799001092	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1028799001093	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1028799001094	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
1028799001095	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1028799001096	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1028799001097	active site
1028799001098	Esterase/lipase [General function prediction only]; Region: COG1647
1028799001099	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1028799001100	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1028799001101	Na2 binding site [ion binding]; other site
1028799001102	putative substrate binding site 1 [chemical binding]; other site
1028799001103	Na binding site 1 [ion binding]; other site
1028799001104	putative substrate binding site 2 [chemical binding]; other site
1028799001105	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1028799001106	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1028799001107	dimer interface [polypeptide binding]; other site
1028799001108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799001109	catalytic residue [active]
1028799001110	cystathionine beta-lyase; Provisional; Region: PRK07671
1028799001111	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1028799001112	homodimer interface [polypeptide binding]; other site
1028799001113	substrate-cofactor binding pocket; other site
1028799001114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799001115	catalytic residue [active]
1028799001116	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1028799001117	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1028799001118	Walker A/P-loop; other site
1028799001119	ATP binding site [chemical binding]; other site
1028799001120	Q-loop/lid; other site
1028799001121	ABC transporter signature motif; other site
1028799001122	Walker B; other site
1028799001123	D-loop; other site
1028799001124	H-loop/switch region; other site
1028799001125	NIL domain; Region: NIL; pfam09383
1028799001126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799001127	dimer interface [polypeptide binding]; other site
1028799001128	conserved gate region; other site
1028799001129	ABC-ATPase subunit interface; other site
1028799001130	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1028799001131	LysM domain; Region: LysM; pfam01476
1028799001132	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1028799001133	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1028799001134	Surface antigen [General function prediction only]; Region: COG3942
1028799001135	CHAP domain; Region: CHAP; pfam05257
1028799001136	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1028799001137	nudix motif; other site
1028799001138	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799001139	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1028799001140	Coenzyme A binding pocket [chemical binding]; other site
1028799001141	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1028799001142	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1028799001143	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1028799001144	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1028799001145	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1028799001146	dimerization interface [polypeptide binding]; other site
1028799001147	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1028799001148	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1028799001149	active site
1028799001150	dimer interface [polypeptide binding]; other site
1028799001151	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1028799001152	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1028799001153	active site
1028799001154	FMN binding site [chemical binding]; other site
1028799001155	substrate binding site [chemical binding]; other site
1028799001156	3Fe-4S cluster binding site [ion binding]; other site
1028799001157	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1028799001158	domain interface; other site
1028799001159	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1028799001160	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1028799001161	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1028799001162	active site turn [active]
1028799001163	phosphorylation site [posttranslational modification]
1028799001164	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1028799001165	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1028799001166	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1028799001167	Ca binding site [ion binding]; other site
1028799001168	active site
1028799001169	catalytic site [active]
1028799001170	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1028799001171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1028799001172	DNA-binding site [nucleotide binding]; DNA binding site
1028799001173	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1028799001174	UTRA domain; Region: UTRA; pfam07702
1028799001175	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1028799001176	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799001177	Coenzyme A binding pocket [chemical binding]; other site
1028799001178	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1028799001179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799001180	Walker A motif; other site
1028799001181	ATP binding site [chemical binding]; other site
1028799001182	Walker B motif; other site
1028799001183	arginine finger; other site
1028799001184	hypothetical protein; Validated; Region: PRK00153
1028799001185	recombination protein RecR; Reviewed; Region: recR; PRK00076
1028799001186	RecR protein; Region: RecR; pfam02132
1028799001187	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1028799001188	putative active site [active]
1028799001189	putative metal-binding site [ion binding]; other site
1028799001190	tetramer interface [polypeptide binding]; other site
1028799001191	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1028799001192	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1028799001193	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1028799001194	catalytic residue [active]
1028799001195	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1028799001196	thymidylate kinase; Validated; Region: tmk; PRK00698
1028799001197	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1028799001198	TMP-binding site; other site
1028799001199	ATP-binding site [chemical binding]; other site
1028799001200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
1028799001201	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1028799001202	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1028799001203	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1028799001204	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
1028799001205	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1028799001206	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799001207	S-adenosylmethionine binding site [chemical binding]; other site
1028799001208	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1028799001209	GIY-YIG motif/motif A; other site
1028799001210	putative active site [active]
1028799001211	putative metal binding site [ion binding]; other site
1028799001212	Predicted methyltransferases [General function prediction only]; Region: COG0313
1028799001213	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1028799001214	putative SAM binding site [chemical binding]; other site
1028799001215	putative homodimer interface [polypeptide binding]; other site
1028799001216	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1028799001217	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1028799001218	active site
1028799001219	HIGH motif; other site
1028799001220	KMSKS motif; other site
1028799001221	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1028799001222	tRNA binding surface [nucleotide binding]; other site
1028799001223	anticodon binding site; other site
1028799001224	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1028799001225	dimer interface [polypeptide binding]; other site
1028799001226	putative tRNA-binding site [nucleotide binding]; other site
1028799001227	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1028799001228	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1028799001229	active site
1028799001230	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1028799001231	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1028799001232	putative active site [active]
1028799001233	putative metal binding site [ion binding]; other site
1028799001234	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1028799001235	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1028799001236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799001237	S-adenosylmethionine binding site [chemical binding]; other site
1028799001238	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1028799001239	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1028799001240	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1028799001241	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1028799001242	pur operon repressor; Provisional; Region: PRK09213
1028799001243	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1028799001244	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1028799001245	active site
1028799001246	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1028799001247	homotrimer interaction site [polypeptide binding]; other site
1028799001248	putative active site [active]
1028799001249	regulatory protein SpoVG; Reviewed; Region: PRK13259
1028799001250	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1028799001251	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1028799001252	Substrate binding site; other site
1028799001253	Mg++ binding site; other site
1028799001254	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1028799001255	active site
1028799001256	substrate binding site [chemical binding]; other site
1028799001257	CoA binding site [chemical binding]; other site
1028799001258	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1028799001259	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1028799001260	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1028799001261	active site
1028799001262	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1028799001263	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1028799001264	5S rRNA interface [nucleotide binding]; other site
1028799001265	CTC domain interface [polypeptide binding]; other site
1028799001266	L16 interface [polypeptide binding]; other site
1028799001267	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1028799001268	putative active site [active]
1028799001269	catalytic residue [active]
1028799001270	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1028799001271	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
1028799001272	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1028799001273	ATP binding site [chemical binding]; other site
1028799001274	putative Mg++ binding site [ion binding]; other site
1028799001275	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1028799001276	nucleotide binding region [chemical binding]; other site
1028799001277	ATP-binding site [chemical binding]; other site
1028799001278	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1028799001279	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1028799001280	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1028799001281	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1028799001282	putative SAM binding site [chemical binding]; other site
1028799001283	putative homodimer interface [polypeptide binding]; other site
1028799001284	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1028799001285	homodimer interface [polypeptide binding]; other site
1028799001286	metal binding site [ion binding]; metal-binding site
1028799001287	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1028799001288	RNA binding surface [nucleotide binding]; other site
1028799001289	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1028799001290	Septum formation initiator; Region: DivIC; pfam04977
1028799001291	hypothetical protein; Provisional; Region: PRK08582
1028799001292	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1028799001293	RNA binding site [nucleotide binding]; other site
1028799001294	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1028799001295	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1028799001296	Ligand Binding Site [chemical binding]; other site
1028799001297	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1028799001298	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1028799001299	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1028799001300	active site
1028799001301	FtsH Extracellular; Region: FtsH_ext; pfam06480
1028799001302	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1028799001303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799001304	Walker A motif; other site
1028799001305	ATP binding site [chemical binding]; other site
1028799001306	Walker B motif; other site
1028799001307	arginine finger; other site
1028799001308	Peptidase family M41; Region: Peptidase_M41; pfam01434
1028799001309	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1028799001310	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1028799001311	dimerization interface [polypeptide binding]; other site
1028799001312	domain crossover interface; other site
1028799001313	redox-dependent activation switch; other site
1028799001314	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1028799001315	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1028799001316	dimer interface [polypeptide binding]; other site
1028799001317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799001318	catalytic residue [active]
1028799001319	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1028799001320	dihydropteroate synthase; Region: DHPS; TIGR01496
1028799001321	substrate binding pocket [chemical binding]; other site
1028799001322	dimer interface [polypeptide binding]; other site
1028799001323	inhibitor binding site; inhibition site
1028799001324	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1028799001325	homooctamer interface [polypeptide binding]; other site
1028799001326	active site
1028799001327	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1028799001328	catalytic center binding site [active]
1028799001329	ATP binding site [chemical binding]; other site
1028799001330	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1028799001331	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1028799001332	dimer interface [polypeptide binding]; other site
1028799001333	putative anticodon binding site; other site
1028799001334	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1028799001335	motif 1; other site
1028799001336	active site
1028799001337	motif 2; other site
1028799001338	motif 3; other site
1028799001339	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1028799001340	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1028799001341	DNA-binding site [nucleotide binding]; DNA binding site
1028799001342	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1028799001343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799001344	homodimer interface [polypeptide binding]; other site
1028799001345	catalytic residue [active]
1028799001346	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1028799001347	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1028799001348	active site
1028799001349	multimer interface [polypeptide binding]; other site
1028799001350	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1028799001351	predicted active site [active]
1028799001352	catalytic triad [active]
1028799001353	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1028799001354	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1028799001355	Nucleoside recognition; Region: Gate; pfam07670
1028799001356	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1028799001357	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
1028799001358	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1028799001359	UvrB/uvrC motif; Region: UVR; pfam02151
1028799001360	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
1028799001361	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1028799001362	ADP binding site [chemical binding]; other site
1028799001363	phosphagen binding site; other site
1028799001364	substrate specificity loop; other site
1028799001365	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1028799001366	Clp amino terminal domain; Region: Clp_N; pfam02861
1028799001367	Clp amino terminal domain; Region: Clp_N; pfam02861
1028799001368	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799001369	Walker A motif; other site
1028799001370	ATP binding site [chemical binding]; other site
1028799001371	Walker B motif; other site
1028799001372	arginine finger; other site
1028799001373	UvrB/uvrC motif; Region: UVR; pfam02151
1028799001374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799001375	Walker A motif; other site
1028799001376	ATP binding site [chemical binding]; other site
1028799001377	Walker B motif; other site
1028799001378	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1028799001379	DNA repair protein RadA; Provisional; Region: PRK11823
1028799001380	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1028799001381	Walker A motif/ATP binding site; other site
1028799001382	ATP binding site [chemical binding]; other site
1028799001383	Walker B motif; other site
1028799001384	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1028799001385	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1028799001386	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1028799001387	putative active site [active]
1028799001388	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1028799001389	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1028799001390	active site
1028799001391	HIGH motif; other site
1028799001392	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1028799001393	active site
1028799001394	KMSKS motif; other site
1028799001395	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1028799001396	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1028799001397	trimer interface [polypeptide binding]; other site
1028799001398	active site
1028799001399	substrate binding site [chemical binding]; other site
1028799001400	CoA binding site [chemical binding]; other site
1028799001401	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1028799001402	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1028799001403	active site
1028799001404	HIGH motif; other site
1028799001405	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1028799001406	KMSKS motif; other site
1028799001407	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1028799001408	tRNA binding surface [nucleotide binding]; other site
1028799001409	anticodon binding site; other site
1028799001410	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1028799001411	active site
1028799001412	dimerization interface [polypeptide binding]; other site
1028799001413	metal binding site [ion binding]; metal-binding site
1028799001414	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1028799001415	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1028799001416	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1028799001417	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
1028799001418	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1028799001419	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1028799001420	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1028799001421	DNA binding residues [nucleotide binding]
1028799001422	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1028799001423	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1028799001424	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1028799001425	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1028799001426	putative homodimer interface [polypeptide binding]; other site
1028799001427	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1028799001428	heterodimer interface [polypeptide binding]; other site
1028799001429	homodimer interface [polypeptide binding]; other site
1028799001430	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1028799001431	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1028799001432	23S rRNA interface [nucleotide binding]; other site
1028799001433	L7/L12 interface [polypeptide binding]; other site
1028799001434	putative thiostrepton binding site; other site
1028799001435	L25 interface [polypeptide binding]; other site
1028799001436	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1028799001437	mRNA/rRNA interface [nucleotide binding]; other site
1028799001438	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1028799001439	23S rRNA interface [nucleotide binding]; other site
1028799001440	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1028799001441	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1028799001442	peripheral dimer interface [polypeptide binding]; other site
1028799001443	core dimer interface [polypeptide binding]; other site
1028799001444	L10 interface [polypeptide binding]; other site
1028799001445	L11 interface [polypeptide binding]; other site
1028799001446	putative EF-Tu interaction site [polypeptide binding]; other site
1028799001447	putative EF-G interaction site [polypeptide binding]; other site
1028799001448	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1028799001449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799001450	S-adenosylmethionine binding site [chemical binding]; other site
1028799001451	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1028799001452	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1028799001453	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1028799001454	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1028799001455	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1028799001456	RPB10 interaction site [polypeptide binding]; other site
1028799001457	RPB1 interaction site [polypeptide binding]; other site
1028799001458	RPB11 interaction site [polypeptide binding]; other site
1028799001459	RPB3 interaction site [polypeptide binding]; other site
1028799001460	RPB12 interaction site [polypeptide binding]; other site
1028799001461	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1028799001462	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1028799001463	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1028799001464	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1028799001465	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1028799001466	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1028799001467	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1028799001468	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1028799001469	G-loop; other site
1028799001470	DNA binding site [nucleotide binding]
1028799001471	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
1028799001472	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1028799001473	S17 interaction site [polypeptide binding]; other site
1028799001474	S8 interaction site; other site
1028799001475	16S rRNA interaction site [nucleotide binding]; other site
1028799001476	streptomycin interaction site [chemical binding]; other site
1028799001477	23S rRNA interaction site [nucleotide binding]; other site
1028799001478	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1028799001479	30S ribosomal protein S7; Validated; Region: PRK05302
1028799001480	elongation factor G; Reviewed; Region: PRK00007
1028799001481	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1028799001482	G1 box; other site
1028799001483	putative GEF interaction site [polypeptide binding]; other site
1028799001484	GTP/Mg2+ binding site [chemical binding]; other site
1028799001485	Switch I region; other site
1028799001486	G2 box; other site
1028799001487	G3 box; other site
1028799001488	Switch II region; other site
1028799001489	G4 box; other site
1028799001490	G5 box; other site
1028799001491	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1028799001492	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1028799001493	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1028799001494	elongation factor Tu; Reviewed; Region: PRK00049
1028799001495	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1028799001496	G1 box; other site
1028799001497	GEF interaction site [polypeptide binding]; other site
1028799001498	GTP/Mg2+ binding site [chemical binding]; other site
1028799001499	Switch I region; other site
1028799001500	G2 box; other site
1028799001501	G3 box; other site
1028799001502	Switch II region; other site
1028799001503	G4 box; other site
1028799001504	G5 box; other site
1028799001505	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1028799001506	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1028799001507	Antibiotic Binding Site [chemical binding]; other site
1028799001508	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1028799001509	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1028799001510	metal binding site [ion binding]; metal-binding site
1028799001511	dimer interface [polypeptide binding]; other site
1028799001512	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1028799001513	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1028799001514	substrate-cofactor binding pocket; other site
1028799001515	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799001516	catalytic residue [active]
1028799001517	chaperone protein HchA; Provisional; Region: PRK04155
1028799001518	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
1028799001519	dimer interface [polypeptide binding]; other site
1028799001520	metal binding site [ion binding]; metal-binding site
1028799001521	potential oxyanion hole; other site
1028799001522	potential catalytic triad [active]
1028799001523	conserved cys residue [active]
1028799001524	ribulokinase; Provisional; Region: PRK04123
1028799001525	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1028799001526	N- and C-terminal domain interface [polypeptide binding]; other site
1028799001527	active site
1028799001528	MgATP binding site [chemical binding]; other site
1028799001529	catalytic site [active]
1028799001530	metal binding site [ion binding]; metal-binding site
1028799001531	carbohydrate binding site [chemical binding]; other site
1028799001532	homodimer interface [polypeptide binding]; other site
1028799001533	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1028799001534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1028799001535	NAD(P) binding site [chemical binding]; other site
1028799001536	active site
1028799001537	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1028799001538	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1028799001539	homodimer interface [polypeptide binding]; other site
1028799001540	substrate-cofactor binding pocket; other site
1028799001541	catalytic residue [active]
1028799001542	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1028799001543	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799001544	motif II; other site
1028799001545	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1028799001546	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1028799001547	Substrate-binding site [chemical binding]; other site
1028799001548	Substrate specificity [chemical binding]; other site
1028799001549	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1028799001550	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1028799001551	Substrate-binding site [chemical binding]; other site
1028799001552	Substrate specificity [chemical binding]; other site
1028799001553	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1028799001554	nucleoside/Zn binding site; other site
1028799001555	dimer interface [polypeptide binding]; other site
1028799001556	catalytic motif [active]
1028799001557	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799001558	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1028799001559	active site
1028799001560	motif I; other site
1028799001561	motif II; other site
1028799001562	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799001563	Predicted flavoprotein [General function prediction only]; Region: COG0431
1028799001564	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1028799001565	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799001566	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1028799001567	Cna protein B-type domain; Region: Cna_B; pfam05738
1028799001568	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1028799001569	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799001570	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1028799001571	Cna protein B-type domain; Region: Cna_B; pfam05738
1028799001572	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1028799001573	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1028799001574	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1028799001575	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1028799001576	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1028799001577	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1028799001578	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1028799001579	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1028799001580	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1028799001581	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1028799001582	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1028799001583	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
1028799001584	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
1028799001585	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1028799001586	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1028799001587	active site
1028799001588	trimer interface [polypeptide binding]; other site
1028799001589	allosteric site; other site
1028799001590	active site lid [active]
1028799001591	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1028799001592	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1028799001593	active site
1028799001594	dimer interface [polypeptide binding]; other site
1028799001595	magnesium binding site [ion binding]; other site
1028799001596	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1028799001597	tetramer interface [polypeptide binding]; other site
1028799001598	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1028799001599	active site
1028799001600	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1028799001601	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799001602	motif II; other site
1028799001603	proline/glycine betaine transporter; Provisional; Region: PRK10642
1028799001604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799001605	putative substrate translocation pore; other site
1028799001606	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1028799001607	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1028799001608	acyl-activating enzyme (AAE) consensus motif; other site
1028799001609	AMP binding site [chemical binding]; other site
1028799001610	active site
1028799001611	CoA binding site [chemical binding]; other site
1028799001612	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1028799001613	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1028799001614	dimer interface [polypeptide binding]; other site
1028799001615	active site
1028799001616	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1028799001617	dimer interface [polypeptide binding]; other site
1028799001618	substrate binding site [chemical binding]; other site
1028799001619	ATP binding site [chemical binding]; other site
1028799001620	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1028799001621	ligand binding site [chemical binding]; other site
1028799001622	active site
1028799001623	UGI interface [polypeptide binding]; other site
1028799001624	catalytic site [active]
1028799001625	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1028799001626	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1028799001627	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1028799001628	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1028799001629	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1028799001630	putative heme peroxidase; Provisional; Region: PRK12276
1028799001631	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1028799001632	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1028799001633	mevalonate kinase; Region: mevalon_kin; TIGR00549
1028799001634	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1028799001635	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1028799001636	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
1028799001637	diphosphomevalonate decarboxylase; Region: PLN02407
1028799001638	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1028799001639	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1028799001640	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1028799001641	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1028799001642	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1028799001643	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1028799001644	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799001645	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1028799001646	Predicted transcriptional regulator [Transcription]; Region: COG1959
1028799001647	Transcriptional regulator; Region: Rrf2; pfam02082
1028799001648	LXG domain of WXG superfamily; Region: LXG; pfam04740
1028799001649	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001650	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001651	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001652	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001653	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001654	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001655	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001656	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001657	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001658	Protein of unknown function (DUF443); Region: DUF443; pfam04276
1028799001659	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1028799001660	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1028799001661	active site
1028799001662	catalytic tetrad [active]
1028799001663	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1028799001664	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1028799001665	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1028799001666	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799001667	Coenzyme A binding pocket [chemical binding]; other site
1028799001668	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1028799001669	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1028799001670	Zn2+ binding site [ion binding]; other site
1028799001671	Mg2+ binding site [ion binding]; other site
1028799001672	YwhD family; Region: YwhD; pfam08741
1028799001673	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1028799001674	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1028799001675	NAD binding site [chemical binding]; other site
1028799001676	substrate binding site [chemical binding]; other site
1028799001677	catalytic Zn binding site [ion binding]; other site
1028799001678	tetramer interface [polypeptide binding]; other site
1028799001679	structural Zn binding site [ion binding]; other site
1028799001680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
1028799001681	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1028799001682	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
1028799001683	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1028799001684	active site
1028799001685	HIGH motif; other site
1028799001686	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1028799001687	KMSK motif region; other site
1028799001688	tRNA binding surface [nucleotide binding]; other site
1028799001689	DALR anticodon binding domain; Region: DALR_1; smart00836
1028799001690	anticodon binding site; other site
1028799001691	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
1028799001692	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1028799001693	minor groove reading motif; other site
1028799001694	helix-hairpin-helix signature motif; other site
1028799001695	substrate binding pocket [chemical binding]; other site
1028799001696	active site
1028799001697	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1028799001698	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1028799001699	putative binding site residues; other site
1028799001700	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799001701	ABC-ATPase subunit  interface; other site
1028799001702	dimer interface [polypeptide binding]; other site
1028799001703	putative PBP binding regions; other site
1028799001704	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1028799001705	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799001706	motif II; other site
1028799001707	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1028799001708	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1028799001709	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1028799001710	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1028799001711	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799001712	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1028799001713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1028799001714	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1028799001715	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1028799001716	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1028799001717	active site
1028799001718	DNA binding site [nucleotide binding]
1028799001719	Int/Topo IB signature motif; other site
1028799001720	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
1028799001721	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1028799001722	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1028799001723	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
1028799001724	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
1028799001725	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
1028799001726	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1028799001727	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1028799001728	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
1028799001729	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
1028799001730	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1028799001731	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1028799001732	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1028799001733	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1028799001734	intersubunit interface [polypeptide binding]; other site
1028799001735	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1028799001736	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799001737	ABC-ATPase subunit  interface; other site
1028799001738	dimer interface [polypeptide binding]; other site
1028799001739	putative PBP binding regions; other site
1028799001740	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1028799001741	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1028799001742	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1028799001743	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1028799001744	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1028799001745	FeoA domain; Region: FeoA; pfam04023
1028799001746	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1028799001747	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1028799001748	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1028799001749	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
1028799001750	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1028799001751	Walker A/P-loop; other site
1028799001752	ATP binding site [chemical binding]; other site
1028799001753	Q-loop/lid; other site
1028799001754	ABC transporter signature motif; other site
1028799001755	Walker B; other site
1028799001756	D-loop; other site
1028799001757	H-loop/switch region; other site
1028799001758	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1028799001759	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1028799001760	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1028799001761	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1028799001762	active site
1028799001763	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1028799001764	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1028799001765	active site
1028799001766	nucleotide binding site [chemical binding]; other site
1028799001767	HIGH motif; other site
1028799001768	KMSKS motif; other site
1028799001769	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1028799001770	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1028799001771	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
1028799001772	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1028799001773	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1028799001774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799001775	Walker A/P-loop; other site
1028799001776	ATP binding site [chemical binding]; other site
1028799001777	Q-loop/lid; other site
1028799001778	ABC transporter signature motif; other site
1028799001779	Walker B; other site
1028799001780	D-loop; other site
1028799001781	H-loop/switch region; other site
1028799001782	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1028799001783	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1028799001784	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1028799001785	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1028799001786	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1028799001787	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1028799001788	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1028799001789	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1028799001790	Walker A/P-loop; other site
1028799001791	ATP binding site [chemical binding]; other site
1028799001792	Q-loop/lid; other site
1028799001793	ABC transporter signature motif; other site
1028799001794	Walker B; other site
1028799001795	D-loop; other site
1028799001796	H-loop/switch region; other site
1028799001797	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1028799001798	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799001799	ABC-ATPase subunit  interface; other site
1028799001800	dimer interface [polypeptide binding]; other site
1028799001801	putative PBP binding regions; other site
1028799001802	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1028799001803	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799001804	ABC-ATPase subunit  interface; other site
1028799001805	dimer interface [polypeptide binding]; other site
1028799001806	putative PBP binding regions; other site
1028799001807	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1028799001808	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1028799001809	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1028799001810	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1028799001811	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
1028799001812	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1028799001813	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1028799001814	Na binding site [ion binding]; other site
1028799001815	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1028799001816	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1028799001817	substrate binding pocket [chemical binding]; other site
1028799001818	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1028799001819	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1028799001820	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799001821	Coenzyme A binding pocket [chemical binding]; other site
1028799001822	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1028799001823	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1028799001824	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1028799001825	NAD(P) binding site [chemical binding]; other site
1028799001826	active site
1028799001827	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1028799001828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799001829	active site
1028799001830	phosphorylation site [posttranslational modification]
1028799001831	intermolecular recognition site; other site
1028799001832	dimerization interface [polypeptide binding]; other site
1028799001833	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1028799001834	DNA binding site [nucleotide binding]
1028799001835	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1028799001836	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1028799001837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799001838	ATP binding site [chemical binding]; other site
1028799001839	Mg2+ binding site [ion binding]; other site
1028799001840	G-X-G motif; other site
1028799001841	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1028799001842	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1028799001843	Walker A/P-loop; other site
1028799001844	ATP binding site [chemical binding]; other site
1028799001845	Q-loop/lid; other site
1028799001846	ABC transporter signature motif; other site
1028799001847	Walker B; other site
1028799001848	D-loop; other site
1028799001849	H-loop/switch region; other site
1028799001850	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1028799001851	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1028799001852	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1028799001853	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1028799001854	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1028799001855	Surface antigen [General function prediction only]; Region: COG3942
1028799001856	CHAP domain; Region: CHAP; pfam05257
1028799001857	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1028799001858	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
1028799001859	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1028799001860	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799001861	hypothetical protein; Provisional; Region: PRK12378
1028799001862	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
1028799001863	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1028799001864	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1028799001865	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1028799001866	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1028799001867	dimerization interface [polypeptide binding]; other site
1028799001868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799001869	sugar efflux transporter; Region: 2A0120; TIGR00899
1028799001870	putative substrate translocation pore; other site
1028799001871	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
1028799001872	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799001873	Coenzyme A binding pocket [chemical binding]; other site
1028799001874	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1028799001875	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1028799001876	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
1028799001877	hypothetical protein; Validated; Region: PRK00124
1028799001878	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1028799001879	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1028799001880	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1028799001881	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1028799001882	Walker A/P-loop; other site
1028799001883	ATP binding site [chemical binding]; other site
1028799001884	Q-loop/lid; other site
1028799001885	ABC transporter signature motif; other site
1028799001886	Walker B; other site
1028799001887	D-loop; other site
1028799001888	H-loop/switch region; other site
1028799001889	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1028799001890	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1028799001891	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1028799001892	Walker A/P-loop; other site
1028799001893	ATP binding site [chemical binding]; other site
1028799001894	Q-loop/lid; other site
1028799001895	ABC transporter signature motif; other site
1028799001896	Walker B; other site
1028799001897	D-loop; other site
1028799001898	H-loop/switch region; other site
1028799001899	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1028799001900	MarR family; Region: MarR; pfam01047
1028799001901	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1028799001902	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1028799001903	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1028799001904	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1028799001905	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1028799001906	active site
1028799001907	catalytic tetrad [active]
1028799001908	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1028799001909	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1028799001910	transmembrane helices; other site
1028799001911	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1028799001912	DNA photolyase; Region: DNA_photolyase; pfam00875
1028799001913	Predicted membrane protein [Function unknown]; Region: COG4330
1028799001914	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
1028799001915	trimer interface [polypeptide binding]; other site
1028799001916	putative Zn binding site [ion binding]; other site
1028799001917	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1028799001918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799001919	putative substrate translocation pore; other site
1028799001920	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1028799001921	putative deacylase active site [active]
1028799001922	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1028799001923	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1028799001924	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1028799001925	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1028799001926	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1028799001927	putative substrate binding site [chemical binding]; other site
1028799001928	putative ATP binding site [chemical binding]; other site
1028799001929	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1028799001930	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1028799001931	active site
1028799001932	phosphorylation site [posttranslational modification]
1028799001933	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1028799001934	active site
1028799001935	P-loop; other site
1028799001936	phosphorylation site [posttranslational modification]
1028799001937	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1028799001938	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1028799001939	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1028799001940	active site
1028799001941	dimer interface [polypeptide binding]; other site
1028799001942	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1028799001943	Domain of unknown function DUF21; Region: DUF21; pfam01595
1028799001944	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1028799001945	Transporter associated domain; Region: CorC_HlyC; pfam03471
1028799001946	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1028799001947	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1028799001948	active site
1028799001949	catalytic tetrad [active]
1028799001950	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1028799001951	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1028799001952	Ligand binding site; other site
1028799001953	Putative Catalytic site; other site
1028799001954	DXD motif; other site
1028799001955	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1028799001956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1028799001957	dimer interface [polypeptide binding]; other site
1028799001958	phosphorylation site [posttranslational modification]
1028799001959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799001960	ATP binding site [chemical binding]; other site
1028799001961	Mg2+ binding site [ion binding]; other site
1028799001962	G-X-G motif; other site
1028799001963	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1028799001964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799001965	active site
1028799001966	phosphorylation site [posttranslational modification]
1028799001967	intermolecular recognition site; other site
1028799001968	dimerization interface [polypeptide binding]; other site
1028799001969	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1028799001970	DNA binding site [nucleotide binding]
1028799001971	DoxX; Region: DoxX; pfam07681
1028799001972	Electron transfer DM13; Region: DM13; pfam10517
1028799001973	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1028799001974	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1028799001975	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
1028799001976	active site
1028799001977	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1028799001978	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1028799001979	Ligand Binding Site [chemical binding]; other site
1028799001980	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1028799001981	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1028799001982	glutamine binding [chemical binding]; other site
1028799001983	catalytic triad [active]
1028799001984	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1028799001985	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1028799001986	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1028799001987	substrate-cofactor binding pocket; other site
1028799001988	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1028799001989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799001990	catalytic residue [active]
1028799001991	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1028799001992	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1028799001993	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1028799001994	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1028799001995	Sulfatase; Region: Sulfatase; pfam00884
1028799001996	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1028799001997	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1028799001998	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1028799001999	ABC transporter; Region: ABC_tran_2; pfam12848
1028799002000	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1028799002001	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1028799002002	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1028799002003	ATP binding site [chemical binding]; other site
1028799002004	putative Mg++ binding site [ion binding]; other site
1028799002005	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1028799002006	nucleotide binding region [chemical binding]; other site
1028799002007	ATP-binding site [chemical binding]; other site
1028799002008	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1028799002009	HRDC domain; Region: HRDC; pfam00570
1028799002010	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1028799002011	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1028799002012	Walker A/P-loop; other site
1028799002013	ATP binding site [chemical binding]; other site
1028799002014	Q-loop/lid; other site
1028799002015	ABC transporter signature motif; other site
1028799002016	Walker B; other site
1028799002017	D-loop; other site
1028799002018	H-loop/switch region; other site
1028799002019	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1028799002020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799002021	dimer interface [polypeptide binding]; other site
1028799002022	conserved gate region; other site
1028799002023	ABC-ATPase subunit interface; other site
1028799002024	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1028799002025	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1028799002026	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1028799002027	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1028799002028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799002029	homodimer interface [polypeptide binding]; other site
1028799002030	catalytic residue [active]
1028799002031	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799002032	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
1028799002033	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1028799002034	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1028799002035	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1028799002036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799002037	putative substrate translocation pore; other site
1028799002038	POT family; Region: PTR2; cl17359
1028799002039	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1028799002040	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1028799002041	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
1028799002042	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
1028799002043	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1028799002044	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1028799002045	active site
1028799002046	dimer interface [polypeptide binding]; other site
1028799002047	catalytic residues [active]
1028799002048	effector binding site; other site
1028799002049	R2 peptide binding site; other site
1028799002050	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1028799002051	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1028799002052	dimer interface [polypeptide binding]; other site
1028799002053	putative radical transfer pathway; other site
1028799002054	diiron center [ion binding]; other site
1028799002055	tyrosyl radical; other site
1028799002056	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799002057	ABC-ATPase subunit  interface; other site
1028799002058	dimer interface [polypeptide binding]; other site
1028799002059	putative PBP binding regions; other site
1028799002060	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799002061	ABC-ATPase subunit  interface; other site
1028799002062	dimer interface [polypeptide binding]; other site
1028799002063	putative PBP binding regions; other site
1028799002064	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1028799002065	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1028799002066	Walker A/P-loop; other site
1028799002067	ATP binding site [chemical binding]; other site
1028799002068	Q-loop/lid; other site
1028799002069	ABC transporter signature motif; other site
1028799002070	Walker B; other site
1028799002071	D-loop; other site
1028799002072	H-loop/switch region; other site
1028799002073	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1028799002074	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1028799002075	putative ligand binding residues [chemical binding]; other site
1028799002076	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
1028799002077	CHY zinc finger; Region: zf-CHY; pfam05495
1028799002078	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
1028799002079	FAD binding domain; Region: FAD_binding_4; pfam01565
1028799002080	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1028799002081	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1028799002082	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
1028799002083	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1028799002084	peptidase T; Region: peptidase-T; TIGR01882
1028799002085	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1028799002086	metal binding site [ion binding]; metal-binding site
1028799002087	dimer interface [polypeptide binding]; other site
1028799002088	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1028799002089	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1028799002090	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1028799002091	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1028799002092	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1028799002093	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1028799002094	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1028799002095	metal binding site [ion binding]; metal-binding site
1028799002096	active site
1028799002097	I-site; other site
1028799002098	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1028799002099	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1028799002100	Mg++ binding site [ion binding]; other site
1028799002101	putative catalytic motif [active]
1028799002102	substrate binding site [chemical binding]; other site
1028799002103	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1028799002104	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1028799002105	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1028799002106	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1028799002107	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1028799002108	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1028799002109	ATP binding site [chemical binding]; other site
1028799002110	putative Mg++ binding site [ion binding]; other site
1028799002111	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1028799002112	nucleotide binding region [chemical binding]; other site
1028799002113	ATP-binding site [chemical binding]; other site
1028799002114	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1028799002115	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1028799002116	active site
1028799002117	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1028799002118	30S subunit binding site; other site
1028799002119	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1028799002120	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1028799002121	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1028799002122	nucleotide binding region [chemical binding]; other site
1028799002123	ATP-binding site [chemical binding]; other site
1028799002124	SEC-C motif; Region: SEC-C; pfam02810
1028799002125	peptide chain release factor 2; Provisional; Region: PRK06746
1028799002126	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1028799002127	RF-1 domain; Region: RF-1; pfam00472
1028799002128	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1028799002129	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1028799002130	Surface antigen [General function prediction only]; Region: COG3942
1028799002131	CHAP domain; Region: CHAP; pfam05257
1028799002132	HD domain; Region: HD_3; cl17350
1028799002133	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
1028799002134	excinuclease ABC subunit B; Provisional; Region: PRK05298
1028799002135	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1028799002136	ATP binding site [chemical binding]; other site
1028799002137	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1028799002138	nucleotide binding region [chemical binding]; other site
1028799002139	ATP-binding site [chemical binding]; other site
1028799002140	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1028799002141	UvrB/uvrC motif; Region: UVR; pfam02151
1028799002142	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1028799002143	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1028799002144	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1028799002145	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1028799002146	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1028799002147	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1028799002148	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1028799002149	Hpr binding site; other site
1028799002150	active site
1028799002151	homohexamer subunit interaction site [polypeptide binding]; other site
1028799002152	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1028799002153	putative acyl transferase; Provisional; Region: PRK10191
1028799002154	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1028799002155	trimer interface [polypeptide binding]; other site
1028799002156	active site
1028799002157	substrate binding site [chemical binding]; other site
1028799002158	CoA binding site [chemical binding]; other site
1028799002159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1028799002160	TPR motif; other site
1028799002161	binding surface
1028799002162	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1028799002163	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1028799002164	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799002165	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
1028799002166	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1028799002167	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
1028799002168	phosphate binding site [ion binding]; other site
1028799002169	dimer interface [polypeptide binding]; other site
1028799002170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1028799002171	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1028799002172	Clp protease; Region: CLP_protease; pfam00574
1028799002173	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1028799002174	oligomer interface [polypeptide binding]; other site
1028799002175	active site residues [active]
1028799002176	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1028799002177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1028799002178	NAD(P) binding site [chemical binding]; other site
1028799002179	active site
1028799002180	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1028799002181	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1028799002182	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1028799002183	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1028799002184	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1028799002185	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1028799002186	Phosphoglycerate kinase; Region: PGK; pfam00162
1028799002187	substrate binding site [chemical binding]; other site
1028799002188	hinge regions; other site
1028799002189	ADP binding site [chemical binding]; other site
1028799002190	catalytic site [active]
1028799002191	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1028799002192	triosephosphate isomerase; Provisional; Region: PRK14565
1028799002193	substrate binding site [chemical binding]; other site
1028799002194	dimer interface [polypeptide binding]; other site
1028799002195	catalytic triad [active]
1028799002196	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1028799002197	phosphoglyceromutase; Provisional; Region: PRK05434
1028799002198	enolase; Provisional; Region: eno; PRK00077
1028799002199	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1028799002200	dimer interface [polypeptide binding]; other site
1028799002201	metal binding site [ion binding]; metal-binding site
1028799002202	substrate binding pocket [chemical binding]; other site
1028799002203	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1028799002204	Esterase/lipase [General function prediction only]; Region: COG1647
1028799002205	Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735
1028799002206	ribonuclease R; Region: RNase_R; TIGR02063
1028799002207	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1028799002208	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1028799002209	RNB domain; Region: RNB; pfam00773
1028799002210	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1028799002211	RNA binding site [nucleotide binding]; other site
1028799002212	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1028799002213	SmpB-tmRNA interface; other site
1028799002214	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799002215	Coenzyme A binding pocket [chemical binding]; other site
1028799002216	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799002217	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1028799002218	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1028799002219	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1028799002220	Staphylococcal nuclease homologues; Region: SNc; smart00318
1028799002221	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1028799002222	Catalytic site; other site
1028799002223	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1028799002224	DNA-binding site [nucleotide binding]; DNA binding site
1028799002225	RNA-binding motif; other site
1028799002226	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
1028799002227	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1028799002228	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1028799002229	catalytic core [active]
1028799002230	Lysine efflux permease [General function prediction only]; Region: COG1279
1028799002231	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1028799002232	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1028799002233	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1028799002234	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1028799002235	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1028799002236	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1028799002237	active site
1028799002238	catalytic residue [active]
1028799002239	dimer interface [polypeptide binding]; other site
1028799002240	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1028799002241	putative FMN binding site [chemical binding]; other site
1028799002242	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1028799002243	catalytic residues [active]
1028799002244	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1028799002245	ArsC family; Region: ArsC; pfam03960
1028799002246	putative ArsC-like catalytic residues; other site
1028799002247	putative TRX-like catalytic residues [active]
1028799002248	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1028799002249	lipoyl attachment site [posttranslational modification]; other site
1028799002250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
1028799002251	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799002252	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799002253	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1028799002254	putative active site [active]
1028799002255	putative metal binding site [ion binding]; other site
1028799002256	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1028799002257	catalytic residues [active]
1028799002258	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1028799002259	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1028799002260	Walker A/P-loop; other site
1028799002261	ATP binding site [chemical binding]; other site
1028799002262	Q-loop/lid; other site
1028799002263	ABC transporter signature motif; other site
1028799002264	Walker B; other site
1028799002265	D-loop; other site
1028799002266	H-loop/switch region; other site
1028799002267	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1028799002268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799002269	dimer interface [polypeptide binding]; other site
1028799002270	conserved gate region; other site
1028799002271	ABC-ATPase subunit interface; other site
1028799002272	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1028799002273	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1028799002274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1028799002275	Predicted membrane protein [Function unknown]; Region: COG2035
1028799002276	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1028799002277	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1028799002278	Walker A/P-loop; other site
1028799002279	ATP binding site [chemical binding]; other site
1028799002280	Q-loop/lid; other site
1028799002281	ABC transporter signature motif; other site
1028799002282	Walker B; other site
1028799002283	D-loop; other site
1028799002284	H-loop/switch region; other site
1028799002285	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1028799002286	FeS assembly protein SufD; Region: sufD; TIGR01981
1028799002287	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1028799002288	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1028799002289	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1028799002290	catalytic residue [active]
1028799002291	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1028799002292	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1028799002293	trimerization site [polypeptide binding]; other site
1028799002294	active site
1028799002295	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1028799002296	FeS assembly protein SufB; Region: sufB; TIGR01980
1028799002297	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1028799002298	Domain of unknown function DUF21; Region: DUF21; pfam01595
1028799002299	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1028799002300	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1028799002301	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1028799002302	FMN binding site [chemical binding]; other site
1028799002303	substrate binding site [chemical binding]; other site
1028799002304	putative catalytic residue [active]
1028799002305	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1028799002306	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1028799002307	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1028799002308	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1028799002309	active site
1028799002310	metal binding site [ion binding]; metal-binding site
1028799002311	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1028799002312	lipoyl synthase; Provisional; Region: PRK05481
1028799002313	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799002314	FeS/SAM binding site; other site
1028799002315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
1028799002316	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1028799002317	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1028799002318	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1028799002319	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799002320	active site
1028799002321	motif I; other site
1028799002322	motif II; other site
1028799002323	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799002324	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1028799002325	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1028799002326	dimerization interface [polypeptide binding]; other site
1028799002327	ligand binding site [chemical binding]; other site
1028799002328	NADP binding site [chemical binding]; other site
1028799002329	catalytic site [active]
1028799002330	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
1028799002331	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1028799002332	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1028799002333	acyl-activating enzyme (AAE) consensus motif; other site
1028799002334	AMP binding site [chemical binding]; other site
1028799002335	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1028799002336	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1028799002337	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1028799002338	DltD N-terminal region; Region: DltD_N; pfam04915
1028799002339	DltD central region; Region: DltD_M; pfam04918
1028799002340	DltD C-terminal region; Region: DltD_C; pfam04914
1028799002341	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1028799002342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
1028799002343	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1028799002344	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799002345	hypothetical protein; Provisional; Region: PRK13669
1028799002346	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1028799002347	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1028799002348	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799002349	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
1028799002350	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1028799002351	interface (dimer of trimers) [polypeptide binding]; other site
1028799002352	Substrate-binding/catalytic site; other site
1028799002353	Zn-binding sites [ion binding]; other site
1028799002354	Predicted permease [General function prediction only]; Region: COG2056
1028799002355	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1028799002356	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1028799002357	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1028799002358	CoenzymeA binding site [chemical binding]; other site
1028799002359	subunit interaction site [polypeptide binding]; other site
1028799002360	PHB binding site; other site
1028799002361	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1028799002362	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1028799002363	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
1028799002364	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
1028799002365	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
1028799002366	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
1028799002367	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1028799002368	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
1028799002369	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
1028799002370	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
1028799002371	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1028799002372	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1028799002373	Kinase associated protein B; Region: KapB; pfam08810
1028799002374	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1028799002375	active site
1028799002376	general stress protein 13; Validated; Region: PRK08059
1028799002377	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1028799002378	RNA binding site [nucleotide binding]; other site
1028799002379	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1028799002380	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1028799002381	putative active site [active]
1028799002382	putative FMN binding site [chemical binding]; other site
1028799002383	putative substrate binding site [chemical binding]; other site
1028799002384	putative catalytic residue [active]
1028799002385	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1028799002386	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1028799002387	inhibitor-cofactor binding pocket; inhibition site
1028799002388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799002389	catalytic residue [active]
1028799002390	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1028799002391	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1028799002392	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1028799002393	NAD(P) binding site [chemical binding]; other site
1028799002394	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1028799002395	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1028799002396	active site
1028799002397	catalytic site [active]
1028799002398	metal binding site [ion binding]; metal-binding site
1028799002399	argininosuccinate lyase; Provisional; Region: PRK00855
1028799002400	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1028799002401	active sites [active]
1028799002402	tetramer interface [polypeptide binding]; other site
1028799002403	argininosuccinate synthase; Provisional; Region: PRK13820
1028799002404	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1028799002405	ANP binding site [chemical binding]; other site
1028799002406	Substrate Binding Site II [chemical binding]; other site
1028799002407	Substrate Binding Site I [chemical binding]; other site
1028799002408	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1028799002409	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1028799002410	active site
1028799002411	dimer interface [polypeptide binding]; other site
1028799002412	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1028799002413	dimer interface [polypeptide binding]; other site
1028799002414	active site
1028799002415	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1028799002416	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1028799002417	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1028799002418	Catalytic site [active]
1028799002419	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1028799002420	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1028799002421	Catalytic site [active]
1028799002422	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1028799002423	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1028799002424	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1028799002425	Part of AAA domain; Region: AAA_19; pfam13245
1028799002426	Family description; Region: UvrD_C_2; pfam13538
1028799002427	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1028799002428	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1028799002429	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1028799002430	hypothetical protein; Provisional; Region: PRK13673
1028799002431	coenzyme A disulfide reductase; Provisional; Region: PRK13512
1028799002432	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1028799002433	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799002434	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1028799002435	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1028799002436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799002437	active site
1028799002438	motif I; other site
1028799002439	motif II; other site
1028799002440	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799002441	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1028799002442	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1028799002443	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1028799002444	catalytic triad [active]
1028799002445	catalytic triad [active]
1028799002446	oxyanion hole [active]
1028799002447	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1028799002448	Clp amino terminal domain; Region: Clp_N; pfam02861
1028799002449	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799002450	Walker A motif; other site
1028799002451	ATP binding site [chemical binding]; other site
1028799002452	Walker B motif; other site
1028799002453	arginine finger; other site
1028799002454	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1028799002455	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799002456	Walker A motif; other site
1028799002457	ATP binding site [chemical binding]; other site
1028799002458	Walker B motif; other site
1028799002459	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1028799002460	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1028799002461	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1028799002462	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1028799002463	dimerization interface [polypeptide binding]; other site
1028799002464	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1028799002465	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1028799002466	active site
1028799002467	catalytic residues [active]
1028799002468	metal binding site [ion binding]; metal-binding site
1028799002469	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1028799002470	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1028799002471	substrate binding site [chemical binding]; other site
1028799002472	MAP domain; Region: MAP; pfam03642
1028799002473	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1028799002474	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1028799002475	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1028799002476	dimer interface [polypeptide binding]; other site
1028799002477	active site
1028799002478	CoA binding pocket [chemical binding]; other site
1028799002479	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1028799002480	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1028799002481	dimer interface [polypeptide binding]; other site
1028799002482	active site
1028799002483	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
1028799002484	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1028799002485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799002486	dimer interface [polypeptide binding]; other site
1028799002487	conserved gate region; other site
1028799002488	putative PBP binding loops; other site
1028799002489	ABC-ATPase subunit interface; other site
1028799002490	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1028799002491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799002492	dimer interface [polypeptide binding]; other site
1028799002493	conserved gate region; other site
1028799002494	putative PBP binding loops; other site
1028799002495	ABC-ATPase subunit interface; other site
1028799002496	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1028799002497	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799002498	Walker A/P-loop; other site
1028799002499	ATP binding site [chemical binding]; other site
1028799002500	Q-loop/lid; other site
1028799002501	ABC transporter signature motif; other site
1028799002502	Walker B; other site
1028799002503	D-loop; other site
1028799002504	H-loop/switch region; other site
1028799002505	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1028799002506	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1028799002507	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799002508	Walker A/P-loop; other site
1028799002509	ATP binding site [chemical binding]; other site
1028799002510	Q-loop/lid; other site
1028799002511	ABC transporter signature motif; other site
1028799002512	Walker B; other site
1028799002513	D-loop; other site
1028799002514	H-loop/switch region; other site
1028799002515	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1028799002516	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1028799002517	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1028799002518	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1028799002519	peptide binding site [polypeptide binding]; other site
1028799002520	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1028799002521	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1028799002522	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1028799002523	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799002524	Walker A/P-loop; other site
1028799002525	ATP binding site [chemical binding]; other site
1028799002526	Q-loop/lid; other site
1028799002527	ABC transporter signature motif; other site
1028799002528	Walker B; other site
1028799002529	D-loop; other site
1028799002530	H-loop/switch region; other site
1028799002531	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1028799002532	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1028799002533	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799002534	Walker A/P-loop; other site
1028799002535	ATP binding site [chemical binding]; other site
1028799002536	Q-loop/lid; other site
1028799002537	ABC transporter signature motif; other site
1028799002538	Walker B; other site
1028799002539	D-loop; other site
1028799002540	H-loop/switch region; other site
1028799002541	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1028799002542	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1028799002543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799002544	dimer interface [polypeptide binding]; other site
1028799002545	conserved gate region; other site
1028799002546	putative PBP binding loops; other site
1028799002547	ABC-ATPase subunit interface; other site
1028799002548	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1028799002549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799002550	dimer interface [polypeptide binding]; other site
1028799002551	conserved gate region; other site
1028799002552	putative PBP binding loops; other site
1028799002553	ABC-ATPase subunit interface; other site
1028799002554	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1028799002555	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1028799002556	active site
1028799002557	HIGH motif; other site
1028799002558	dimer interface [polypeptide binding]; other site
1028799002559	KMSKS motif; other site
1028799002560	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1028799002561	ArsC family; Region: ArsC; pfam03960
1028799002562	putative catalytic residues [active]
1028799002563	thiol/disulfide switch; other site
1028799002564	adaptor protein; Provisional; Region: PRK02315
1028799002565	Competence protein CoiA-like family; Region: CoiA; cl11541
1028799002566	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1028799002567	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1028799002568	active site
1028799002569	Zn binding site [ion binding]; other site
1028799002570	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1028799002571	Thioredoxin; Region: Thioredoxin_5; pfam13743
1028799002572	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1028799002573	apolar tunnel; other site
1028799002574	heme binding site [chemical binding]; other site
1028799002575	dimerization interface [polypeptide binding]; other site
1028799002576	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1028799002577	putative active site [active]
1028799002578	putative metal binding residues [ion binding]; other site
1028799002579	signature motif; other site
1028799002580	putative triphosphate binding site [ion binding]; other site
1028799002581	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1028799002582	synthetase active site [active]
1028799002583	NTP binding site [chemical binding]; other site
1028799002584	metal binding site [ion binding]; metal-binding site
1028799002585	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1028799002586	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1028799002587	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1028799002588	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1028799002589	active site
1028799002590	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1028799002591	MgtE intracellular N domain; Region: MgtE_N; smart00924
1028799002592	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1028799002593	Divalent cation transporter; Region: MgtE; pfam01769
1028799002594	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1028799002595	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1028799002596	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1028799002597	TrkA-N domain; Region: TrkA_N; pfam02254
1028799002598	TrkA-C domain; Region: TrkA_C; pfam02080
1028799002599	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1028799002600	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1028799002601	NAD binding site [chemical binding]; other site
1028799002602	homotetramer interface [polypeptide binding]; other site
1028799002603	homodimer interface [polypeptide binding]; other site
1028799002604	substrate binding site [chemical binding]; other site
1028799002605	active site
1028799002606	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1028799002607	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1028799002608	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1028799002609	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1028799002610	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1028799002611	Putative esterase; Region: Esterase; pfam00756
1028799002612	hypothetical protein; Provisional; Region: PRK13679
1028799002613	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1028799002614	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799002615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799002616	putative substrate translocation pore; other site
1028799002617	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
1028799002618	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1028799002619	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1028799002620	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1028799002621	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1028799002622	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1028799002623	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1028799002624	YueH-like protein; Region: YueH; pfam14166
1028799002625	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1028799002626	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1028799002627	G1 box; other site
1028799002628	putative GEF interaction site [polypeptide binding]; other site
1028799002629	GTP/Mg2+ binding site [chemical binding]; other site
1028799002630	Switch I region; other site
1028799002631	G2 box; other site
1028799002632	G3 box; other site
1028799002633	Switch II region; other site
1028799002634	G4 box; other site
1028799002635	G5 box; other site
1028799002636	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1028799002637	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1028799002638	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1028799002639	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1028799002640	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1028799002641	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1028799002642	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1028799002643	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1028799002644	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1028799002645	active site
1028799002646	metal binding site [ion binding]; metal-binding site
1028799002647	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1028799002648	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
1028799002649	IDEAL domain; Region: IDEAL; pfam08858
1028799002650	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1028799002651	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1028799002652	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1028799002653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
1028799002654	CAAX protease self-immunity; Region: Abi; pfam02517
1028799002655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
1028799002656	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
1028799002657	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
1028799002658	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1028799002659	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1028799002660	Walker A/P-loop; other site
1028799002661	ATP binding site [chemical binding]; other site
1028799002662	Q-loop/lid; other site
1028799002663	ABC transporter signature motif; other site
1028799002664	Walker B; other site
1028799002665	D-loop; other site
1028799002666	H-loop/switch region; other site
1028799002667	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1028799002668	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1028799002669	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1028799002670	Predicted membrane protein [Function unknown]; Region: COG2259
1028799002671	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1028799002672	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1028799002673	siderophore binding site; other site
1028799002674	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1028799002675	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799002676	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1028799002677	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1028799002678	Coenzyme A binding pocket [chemical binding]; other site
1028799002679	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1028799002680	UbiA prenyltransferase family; Region: UbiA; pfam01040
1028799002681	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1028799002682	isochorismate synthases; Region: isochor_syn; TIGR00543
1028799002683	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1028799002684	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1028799002685	dimer interface [polypeptide binding]; other site
1028799002686	tetramer interface [polypeptide binding]; other site
1028799002687	PYR/PP interface [polypeptide binding]; other site
1028799002688	TPP binding site [chemical binding]; other site
1028799002689	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1028799002690	TPP-binding site; other site
1028799002691	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1028799002692	PGAP1-like protein; Region: PGAP1; pfam07819
1028799002693	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1028799002694	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1028799002695	substrate binding site [chemical binding]; other site
1028799002696	oxyanion hole (OAH) forming residues; other site
1028799002697	trimer interface [polypeptide binding]; other site
1028799002698	Staphostatin B; Region: Staphostatin_B; pfam09023
1028799002699	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1028799002700	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1028799002701	aminotransferase A; Validated; Region: PRK07683
1028799002702	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1028799002703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799002704	homodimer interface [polypeptide binding]; other site
1028799002705	catalytic residue [active]
1028799002706	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1028799002707	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1028799002708	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1028799002709	MarR family; Region: MarR; pfam01047
1028799002710	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1028799002711	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1028799002712	amidase catalytic site [active]
1028799002713	Zn binding residues [ion binding]; other site
1028799002714	substrate binding site [chemical binding]; other site
1028799002715	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1028799002716	Lysozyme subfamily 2; Region: LYZ2; smart00047
1028799002717	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799002718	Coenzyme A binding pocket [chemical binding]; other site
1028799002719	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
1028799002720	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1028799002721	Beta-lactamase; Region: Beta-lactamase; pfam00144
1028799002722	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1028799002723	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
1028799002724	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1028799002725	Subunit I/III interface [polypeptide binding]; other site
1028799002726	Subunit III/IV interface [polypeptide binding]; other site
1028799002727	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1028799002728	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1028799002729	D-pathway; other site
1028799002730	Putative ubiquinol binding site [chemical binding]; other site
1028799002731	Low-spin heme (heme b) binding site [chemical binding]; other site
1028799002732	Putative water exit pathway; other site
1028799002733	Binuclear center (heme o3/CuB) [ion binding]; other site
1028799002734	K-pathway; other site
1028799002735	Putative proton exit pathway; other site
1028799002736	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1028799002737	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1028799002738	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1028799002739	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1028799002740	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
1028799002741	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1028799002742	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1028799002743	homodimer interface [polypeptide binding]; other site
1028799002744	NADP binding site [chemical binding]; other site
1028799002745	substrate binding site [chemical binding]; other site
1028799002746	AIR carboxylase; Region: AIRC; cl00310
1028799002747	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1028799002748	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1028799002749	NAD binding site [chemical binding]; other site
1028799002750	ATP-grasp domain; Region: ATP-grasp; pfam02222
1028799002751	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1028799002752	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1028799002753	ATP binding site [chemical binding]; other site
1028799002754	active site
1028799002755	substrate binding site [chemical binding]; other site
1028799002756	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
1028799002757	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1028799002758	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1028799002759	putative active site [active]
1028799002760	catalytic triad [active]
1028799002761	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1028799002762	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1028799002763	dimerization interface [polypeptide binding]; other site
1028799002764	ATP binding site [chemical binding]; other site
1028799002765	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1028799002766	dimerization interface [polypeptide binding]; other site
1028799002767	ATP binding site [chemical binding]; other site
1028799002768	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1028799002769	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1028799002770	active site
1028799002771	tetramer interface [polypeptide binding]; other site
1028799002772	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1028799002773	active site
1028799002774	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1028799002775	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1028799002776	dimerization interface [polypeptide binding]; other site
1028799002777	putative ATP binding site [chemical binding]; other site
1028799002778	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
1028799002779	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1028799002780	active site
1028799002781	substrate binding site [chemical binding]; other site
1028799002782	cosubstrate binding site; other site
1028799002783	catalytic site [active]
1028799002784	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1028799002785	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1028799002786	purine monophosphate binding site [chemical binding]; other site
1028799002787	dimer interface [polypeptide binding]; other site
1028799002788	putative catalytic residues [active]
1028799002789	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1028799002790	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1028799002791	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1028799002792	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
1028799002793	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1028799002794	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1028799002795	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1028799002796	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1028799002797	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1028799002798	Walker A/P-loop; other site
1028799002799	ATP binding site [chemical binding]; other site
1028799002800	Q-loop/lid; other site
1028799002801	ABC transporter signature motif; other site
1028799002802	Walker B; other site
1028799002803	D-loop; other site
1028799002804	H-loop/switch region; other site
1028799002805	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
1028799002806	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1028799002807	Walker A/P-loop; other site
1028799002808	ATP binding site [chemical binding]; other site
1028799002809	Q-loop/lid; other site
1028799002810	ABC transporter signature motif; other site
1028799002811	Walker B; other site
1028799002812	D-loop; other site
1028799002813	H-loop/switch region; other site
1028799002814	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
1028799002815	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1028799002816	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1028799002817	putative RNA binding site [nucleotide binding]; other site
1028799002818	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1028799002819	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1028799002820	dimerization domain swap beta strand [polypeptide binding]; other site
1028799002821	regulatory protein interface [polypeptide binding]; other site
1028799002822	active site
1028799002823	regulatory phosphorylation site [posttranslational modification]; other site
1028799002824	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1028799002825	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1028799002826	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1028799002827	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1028799002828	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1028799002829	catalytic residues [active]
1028799002830	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1028799002831	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1028799002832	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1028799002833	TrkA-N domain; Region: TrkA_N; pfam02254
1028799002834	TrkA-C domain; Region: TrkA_C; pfam02080
1028799002835	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1028799002836	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1028799002837	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1028799002838	hypothetical protein; Provisional; Region: PRK13667
1028799002839	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1028799002840	active site
1028799002841	catalytic residues [active]
1028799002842	metal binding site [ion binding]; metal-binding site
1028799002843	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1028799002844	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1028799002845	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1028799002846	TPP-binding site [chemical binding]; other site
1028799002847	tetramer interface [polypeptide binding]; other site
1028799002848	heterodimer interface [polypeptide binding]; other site
1028799002849	phosphorylation loop region [posttranslational modification]
1028799002850	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1028799002851	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1028799002852	alpha subunit interface [polypeptide binding]; other site
1028799002853	TPP binding site [chemical binding]; other site
1028799002854	heterodimer interface [polypeptide binding]; other site
1028799002855	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1028799002856	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1028799002857	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1028799002858	E3 interaction surface; other site
1028799002859	lipoyl attachment site [posttranslational modification]; other site
1028799002860	e3 binding domain; Region: E3_binding; pfam02817
1028799002861	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1028799002862	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1028799002863	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1028799002864	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799002865	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1028799002866	hypothetical protein; Provisional; Region: PRK04387
1028799002867	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1028799002868	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1028799002869	non-specific DNA binding site [nucleotide binding]; other site
1028799002870	salt bridge; other site
1028799002871	sequence-specific DNA binding site [nucleotide binding]; other site
1028799002872	Cupin domain; Region: Cupin_2; pfam07883
1028799002873	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1028799002874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799002875	Walker A/P-loop; other site
1028799002876	ATP binding site [chemical binding]; other site
1028799002877	Q-loop/lid; other site
1028799002878	ABC transporter signature motif; other site
1028799002879	Walker B; other site
1028799002880	D-loop; other site
1028799002881	H-loop/switch region; other site
1028799002882	TOBE domain; Region: TOBE_2; pfam08402
1028799002883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799002884	putative PBP binding loops; other site
1028799002885	dimer interface [polypeptide binding]; other site
1028799002886	ABC-ATPase subunit interface; other site
1028799002887	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1028799002888	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799002889	dimer interface [polypeptide binding]; other site
1028799002890	conserved gate region; other site
1028799002891	putative PBP binding loops; other site
1028799002892	ABC-ATPase subunit interface; other site
1028799002893	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1028799002894	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
1028799002895	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1028799002896	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1028799002897	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1028799002898	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1028799002899	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1028799002900	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1028799002901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1028799002902	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1028799002903	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1028799002904	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1028799002905	active site
1028799002906	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1028799002907	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1028799002908	G1 box; other site
1028799002909	putative GEF interaction site [polypeptide binding]; other site
1028799002910	GTP/Mg2+ binding site [chemical binding]; other site
1028799002911	Switch I region; other site
1028799002912	G2 box; other site
1028799002913	G3 box; other site
1028799002914	Switch II region; other site
1028799002915	G4 box; other site
1028799002916	G5 box; other site
1028799002917	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1028799002918	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1028799002919	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
1028799002920	hypothetical protein; Provisional; Region: PRK13666
1028799002921	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1028799002922	pyruvate carboxylase; Reviewed; Region: PRK12999
1028799002923	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1028799002924	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1028799002925	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1028799002926	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1028799002927	active site
1028799002928	catalytic residues [active]
1028799002929	metal binding site [ion binding]; metal-binding site
1028799002930	homodimer binding site [polypeptide binding]; other site
1028799002931	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1028799002932	carboxyltransferase (CT) interaction site; other site
1028799002933	biotinylation site [posttranslational modification]; other site
1028799002934	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1028799002935	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1028799002936	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1028799002937	UbiA prenyltransferase family; Region: UbiA; pfam01040
1028799002938	Predicted membrane protein [Function unknown]; Region: COG2322
1028799002939	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1028799002940	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1028799002941	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
1028799002942	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1028799002943	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1028799002944	putative active site [active]
1028799002945	catalytic site [active]
1028799002946	putative metal binding site [ion binding]; other site
1028799002947	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471
1028799002948	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1028799002949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799002950	S-adenosylmethionine binding site [chemical binding]; other site
1028799002951	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1028799002952	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1028799002953	active site
1028799002954	(T/H)XGH motif; other site
1028799002955	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
1028799002956	hypothetical protein; Provisional; Region: PRK13670
1028799002957	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1028799002958	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1028799002959	heme uptake protein IsdB; Region: IsdB; TIGR03657
1028799002960	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799002961	NEAr Transporter domain; Region: NEAT; smart00725
1028799002962	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1028799002963	heme-binding site [chemical binding]; other site
1028799002964	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1028799002965	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
1028799002966	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1028799002967	heme-binding site [chemical binding]; other site
1028799002968	heme uptake protein IsdC; Region: IsdC; TIGR03656
1028799002969	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1028799002970	heme-binding site [chemical binding]; other site
1028799002971	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
1028799002972	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1028799002973	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1028799002974	intersubunit interface [polypeptide binding]; other site
1028799002975	FecCD transport family; Region: FecCD; pfam01032
1028799002976	ABC-ATPase subunit  interface; other site
1028799002977	dimer interface [polypeptide binding]; other site
1028799002978	putative PBP binding regions; other site
1028799002979	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1028799002980	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1028799002981	active site
1028799002982	catalytic site [active]
1028799002983	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312
1028799002984	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1028799002985	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1028799002986	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1028799002987	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1028799002988	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1028799002989	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1028799002990	dimer interface [polypeptide binding]; other site
1028799002991	motif 1; other site
1028799002992	active site
1028799002993	motif 2; other site
1028799002994	motif 3; other site
1028799002995	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1028799002996	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1028799002997	putative tRNA-binding site [nucleotide binding]; other site
1028799002998	B3/4 domain; Region: B3_4; pfam03483
1028799002999	tRNA synthetase B5 domain; Region: B5; smart00874
1028799003000	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1028799003001	dimer interface [polypeptide binding]; other site
1028799003002	motif 1; other site
1028799003003	motif 3; other site
1028799003004	motif 2; other site
1028799003005	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1028799003006	ribonuclease HIII; Provisional; Region: PRK00996
1028799003007	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1028799003008	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1028799003009	RNA/DNA hybrid binding site [nucleotide binding]; other site
1028799003010	active site
1028799003011	Cell division protein ZapA; Region: ZapA; cl01146
1028799003012	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1028799003013	Colicin V production protein; Region: Colicin_V; pfam02674
1028799003014	hypothetical protein; Provisional; Region: PRK08609
1028799003015	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1028799003016	active site
1028799003017	primer binding site [nucleotide binding]; other site
1028799003018	NTP  binding site [chemical binding]; other site
1028799003019	metal binding triad [ion binding]; metal-binding site
1028799003020	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1028799003021	active site
1028799003022	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1028799003023	MutS domain III; Region: MutS_III; pfam05192
1028799003024	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1028799003025	Walker A/P-loop; other site
1028799003026	ATP binding site [chemical binding]; other site
1028799003027	Q-loop/lid; other site
1028799003028	ABC transporter signature motif; other site
1028799003029	Walker B; other site
1028799003030	D-loop; other site
1028799003031	H-loop/switch region; other site
1028799003032	Smr domain; Region: Smr; pfam01713
1028799003033	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1028799003034	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1028799003035	catalytic residues [active]
1028799003036	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1028799003037	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1028799003038	GIY-YIG motif/motif A; other site
1028799003039	active site
1028799003040	catalytic site [active]
1028799003041	putative DNA binding site [nucleotide binding]; other site
1028799003042	metal binding site [ion binding]; metal-binding site
1028799003043	UvrB/uvrC motif; Region: UVR; pfam02151
1028799003044	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1028799003045	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1028799003046	putative Iron-sulfur protein interface [polypeptide binding]; other site
1028799003047	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1028799003048	proximal heme binding site [chemical binding]; other site
1028799003049	distal heme binding site [chemical binding]; other site
1028799003050	putative dimer interface [polypeptide binding]; other site
1028799003051	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1028799003052	L-aspartate oxidase; Provisional; Region: PRK06175
1028799003053	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1028799003054	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1028799003055	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1028799003056	glutamate racemase; Provisional; Region: PRK00865
1028799003057	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1028799003058	active site
1028799003059	dimerization interface [polypeptide binding]; other site
1028799003060	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1028799003061	active site
1028799003062	metal binding site [ion binding]; metal-binding site
1028799003063	homotetramer interface [polypeptide binding]; other site
1028799003064	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1028799003065	formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033
1028799003066	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1028799003067	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
1028799003068	beta-channel forming cytolysin; Region: hlyII; TIGR01002
1028799003069	superantigen-like protein; Reviewed; Region: PRK13350
1028799003070	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799003071	superantigen-like protein; Reviewed; Region: PRK13349
1028799003072	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799003073	superantigen-like protein; Reviewed; Region: PRK13043
1028799003074	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799003075	ornithine carbamoyltransferase; Provisional; Region: PRK04284
1028799003076	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1028799003077	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1028799003078	carbamate kinase; Reviewed; Region: PRK12686
1028799003079	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1028799003080	putative substrate binding site [chemical binding]; other site
1028799003081	nucleotide binding site [chemical binding]; other site
1028799003082	nucleotide binding site [chemical binding]; other site
1028799003083	homodimer interface [polypeptide binding]; other site
1028799003084	Predicted membrane protein [Function unknown]; Region: COG1288
1028799003085	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1028799003086	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1028799003087	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1028799003088	gating phenylalanine in ion channel; other site
1028799003089	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
1028799003090	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
1028799003091	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1028799003092	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799003093	motif II; other site
1028799003094	hypothetical protein; Provisional; Region: PRK13688
1028799003095	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1028799003096	Coenzyme A binding pocket [chemical binding]; other site
1028799003097	MraZ protein; Region: MraZ; pfam02381
1028799003098	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1028799003099	MraW methylase family; Region: Methyltransf_5; pfam01795
1028799003100	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
1028799003101	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1028799003102	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1028799003103	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1028799003104	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1028799003105	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1028799003106	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1028799003107	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1028799003108	Mg++ binding site [ion binding]; other site
1028799003109	putative catalytic motif [active]
1028799003110	putative substrate binding site [chemical binding]; other site
1028799003111	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1028799003112	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1028799003113	NAD binding site [chemical binding]; other site
1028799003114	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1028799003115	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1028799003116	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1028799003117	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1028799003118	Cell division protein FtsQ; Region: FtsQ; pfam03799
1028799003119	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1028799003120	Cell division protein FtsA; Region: FtsA; smart00842
1028799003121	Cell division protein FtsA; Region: FtsA; pfam14450
1028799003122	cell division protein FtsZ; Validated; Region: PRK09330
1028799003123	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1028799003124	nucleotide binding site [chemical binding]; other site
1028799003125	SulA interaction site; other site
1028799003126	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1028799003127	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1028799003128	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1028799003129	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1028799003130	catalytic residue [active]
1028799003131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1028799003132	YGGT family; Region: YGGT; pfam02325
1028799003133	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1028799003134	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1028799003135	RNA binding surface [nucleotide binding]; other site
1028799003136	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1028799003137	DivIVA domain; Region: DivI1A_domain; TIGR03544
1028799003138	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1028799003139	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1028799003140	HIGH motif; other site
1028799003141	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1028799003142	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1028799003143	active site
1028799003144	KMSKS motif; other site
1028799003145	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1028799003146	tRNA binding surface [nucleotide binding]; other site
1028799003147	anticodon binding site; other site
1028799003148	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1028799003149	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1028799003150	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1028799003151	active site
1028799003152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1028799003153	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1028799003154	lipoprotein signal peptidase; Provisional; Region: PRK14787
1028799003155	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1028799003156	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1028799003157	RNA binding surface [nucleotide binding]; other site
1028799003158	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1028799003159	active site
1028799003160	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1028799003161	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
1028799003162	uracil transporter; Provisional; Region: PRK10720
1028799003163	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1028799003164	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1028799003165	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1028799003166	dihydroorotase; Validated; Region: pyrC; PRK09357
1028799003167	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1028799003168	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1028799003169	active site
1028799003170	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1028799003171	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1028799003172	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1028799003173	catalytic site [active]
1028799003174	subunit interface [polypeptide binding]; other site
1028799003175	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1028799003176	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1028799003177	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1028799003178	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1028799003179	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1028799003180	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1028799003181	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1028799003182	IMP binding site; other site
1028799003183	dimer interface [polypeptide binding]; other site
1028799003184	interdomain contacts; other site
1028799003185	partial ornithine binding site; other site
1028799003186	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1028799003187	active site
1028799003188	dimer interface [polypeptide binding]; other site
1028799003189	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1028799003190	active site
1028799003191	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1028799003192	dimer interface [polypeptide binding]; other site
1028799003193	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1028799003194	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1028799003195	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1028799003196	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1028799003197	catalytic site [active]
1028799003198	G-X2-G-X-G-K; other site
1028799003199	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
1028799003200	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1028799003201	Flavoprotein; Region: Flavoprotein; pfam02441
1028799003202	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1028799003203	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1028799003204	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1028799003205	ATP binding site [chemical binding]; other site
1028799003206	putative Mg++ binding site [ion binding]; other site
1028799003207	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1028799003208	nucleotide binding region [chemical binding]; other site
1028799003209	ATP-binding site [chemical binding]; other site
1028799003210	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1028799003211	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1028799003212	active site
1028799003213	catalytic residues [active]
1028799003214	metal binding site [ion binding]; metal-binding site
1028799003215	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1028799003216	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1028799003217	putative active site [active]
1028799003218	substrate binding site [chemical binding]; other site
1028799003219	putative cosubstrate binding site; other site
1028799003220	catalytic site [active]
1028799003221	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1028799003222	substrate binding site [chemical binding]; other site
1028799003223	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1028799003224	NusB family; Region: NusB; pfam01029
1028799003225	putative RNA binding site [nucleotide binding]; other site
1028799003226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799003227	S-adenosylmethionine binding site [chemical binding]; other site
1028799003228	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1028799003229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799003230	FeS/SAM binding site; other site
1028799003231	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1028799003232	Protein phosphatase 2C; Region: PP2C; pfam00481
1028799003233	active site
1028799003234	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1028799003235	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1028799003236	active site
1028799003237	ATP binding site [chemical binding]; other site
1028799003238	substrate binding site [chemical binding]; other site
1028799003239	activation loop (A-loop); other site
1028799003240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1028799003241	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1028799003242	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1028799003243	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1028799003244	Predicted GTPases [General function prediction only]; Region: COG1162
1028799003245	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1028799003246	RNA binding site [nucleotide binding]; other site
1028799003247	homodimer interface [polypeptide binding]; other site
1028799003248	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
1028799003249	G4 box; other site
1028799003250	G5 box; other site
1028799003251	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1028799003252	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1028799003253	substrate binding site [chemical binding]; other site
1028799003254	hexamer interface [polypeptide binding]; other site
1028799003255	metal binding site [ion binding]; metal-binding site
1028799003256	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1028799003257	Thiamine pyrophosphokinase; Region: TPK; cd07995
1028799003258	active site
1028799003259	dimerization interface [polypeptide binding]; other site
1028799003260	thiamine binding site [chemical binding]; other site
1028799003261	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1028799003262	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1028799003263	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
1028799003264	DAK2 domain; Region: Dak2; pfam02734
1028799003265	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1028799003266	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1028799003267	generic binding surface II; other site
1028799003268	ssDNA binding site; other site
1028799003269	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1028799003270	ATP binding site [chemical binding]; other site
1028799003271	putative Mg++ binding site [ion binding]; other site
1028799003272	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1028799003273	nucleotide binding region [chemical binding]; other site
1028799003274	ATP-binding site [chemical binding]; other site
1028799003275	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1028799003276	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1028799003277	active site 2 [active]
1028799003278	active site 1 [active]
1028799003279	putative phosphate acyltransferase; Provisional; Region: PRK05331
1028799003280	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1028799003281	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1028799003282	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1028799003283	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1028799003284	NAD(P) binding site [chemical binding]; other site
1028799003285	homotetramer interface [polypeptide binding]; other site
1028799003286	homodimer interface [polypeptide binding]; other site
1028799003287	active site
1028799003288	acyl carrier protein; Provisional; Region: acpP; PRK00982
1028799003289	ribonuclease III; Reviewed; Region: rnc; PRK00102
1028799003290	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1028799003291	dimerization interface [polypeptide binding]; other site
1028799003292	active site
1028799003293	metal binding site [ion binding]; metal-binding site
1028799003294	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1028799003295	dsRNA binding site [nucleotide binding]; other site
1028799003296	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1028799003297	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1028799003298	Walker A/P-loop; other site
1028799003299	ATP binding site [chemical binding]; other site
1028799003300	Q-loop/lid; other site
1028799003301	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1028799003302	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1028799003303	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1028799003304	ABC transporter signature motif; other site
1028799003305	Walker B; other site
1028799003306	D-loop; other site
1028799003307	H-loop/switch region; other site
1028799003308	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1028799003309	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1028799003310	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1028799003311	P loop; other site
1028799003312	GTP binding site [chemical binding]; other site
1028799003313	putative DNA-binding protein; Validated; Region: PRK00118
1028799003314	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1028799003315	signal recognition particle protein; Provisional; Region: PRK10867
1028799003316	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1028799003317	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1028799003318	P loop; other site
1028799003319	GTP binding site [chemical binding]; other site
1028799003320	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1028799003321	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
1028799003322	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1028799003323	RimM N-terminal domain; Region: RimM; pfam01782
1028799003324	PRC-barrel domain; Region: PRC; pfam05239
1028799003325	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1028799003326	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1028799003327	Predicted membrane protein [Function unknown]; Region: COG4485
1028799003328	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1028799003329	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1028799003330	GTP/Mg2+ binding site [chemical binding]; other site
1028799003331	G4 box; other site
1028799003332	G5 box; other site
1028799003333	G1 box; other site
1028799003334	Switch I region; other site
1028799003335	G2 box; other site
1028799003336	G3 box; other site
1028799003337	Switch II region; other site
1028799003338	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1028799003339	RNA/DNA hybrid binding site [nucleotide binding]; other site
1028799003340	active site
1028799003341	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1028799003342	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1028799003343	CoA-ligase; Region: Ligase_CoA; pfam00549
1028799003344	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1028799003345	CoA binding domain; Region: CoA_binding; pfam02629
1028799003346	CoA-ligase; Region: Ligase_CoA; pfam00549
1028799003347	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1028799003348	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1028799003349	CHAP domain; Region: CHAP; pfam05257
1028799003350	FemAB family; Region: FemAB; pfam02388
1028799003351	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1028799003352	DNA protecting protein DprA; Region: dprA; TIGR00732
1028799003353	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1028799003354	DNA topoisomerase I; Validated; Region: PRK05582
1028799003355	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1028799003356	active site
1028799003357	interdomain interaction site; other site
1028799003358	putative metal-binding site [ion binding]; other site
1028799003359	nucleotide binding site [chemical binding]; other site
1028799003360	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1028799003361	domain I; other site
1028799003362	DNA binding groove [nucleotide binding]
1028799003363	phosphate binding site [ion binding]; other site
1028799003364	domain II; other site
1028799003365	domain III; other site
1028799003366	nucleotide binding site [chemical binding]; other site
1028799003367	catalytic site [active]
1028799003368	domain IV; other site
1028799003369	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1028799003370	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1028799003371	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1028799003372	Glucose inhibited division protein A; Region: GIDA; pfam01134
1028799003373	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1028799003374	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1028799003375	active site
1028799003376	DNA binding site [nucleotide binding]
1028799003377	Int/Topo IB signature motif; other site
1028799003378	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1028799003379	active site
1028799003380	HslU subunit interaction site [polypeptide binding]; other site
1028799003381	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1028799003382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799003383	Walker A motif; other site
1028799003384	ATP binding site [chemical binding]; other site
1028799003385	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1028799003386	Walker B motif; other site
1028799003387	arginine finger; other site
1028799003388	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1028799003389	transcriptional repressor CodY; Validated; Region: PRK04158
1028799003390	CodY GAF-like domain; Region: CodY; pfam06018
1028799003391	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1028799003392	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1028799003393	rRNA interaction site [nucleotide binding]; other site
1028799003394	S8 interaction site; other site
1028799003395	putative laminin-1 binding site; other site
1028799003396	elongation factor Ts; Provisional; Region: tsf; PRK09377
1028799003397	UBA/TS-N domain; Region: UBA; pfam00627
1028799003398	Elongation factor TS; Region: EF_TS; pfam00889
1028799003399	Elongation factor TS; Region: EF_TS; pfam00889
1028799003400	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1028799003401	putative nucleotide binding site [chemical binding]; other site
1028799003402	uridine monophosphate binding site [chemical binding]; other site
1028799003403	homohexameric interface [polypeptide binding]; other site
1028799003404	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1028799003405	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1028799003406	hinge region; other site
1028799003407	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1028799003408	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1028799003409	catalytic residue [active]
1028799003410	putative FPP diphosphate  binding site; other site
1028799003411	putative FPP binding hydrophobic cleft; other site
1028799003412	dimer interface [polypeptide binding]; other site
1028799003413	putative IPP diphosphate binding site; other site
1028799003414	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1028799003415	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1028799003416	RIP metalloprotease RseP; Region: TIGR00054
1028799003417	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1028799003418	active site
1028799003419	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1028799003420	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1028799003421	protein binding site [polypeptide binding]; other site
1028799003422	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1028799003423	putative substrate binding region [chemical binding]; other site
1028799003424	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1028799003425	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1028799003426	dimer interface [polypeptide binding]; other site
1028799003427	motif 1; other site
1028799003428	active site
1028799003429	motif 2; other site
1028799003430	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1028799003431	putative deacylase active site [active]
1028799003432	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1028799003433	active site
1028799003434	motif 3; other site
1028799003435	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1028799003436	anticodon binding site; other site
1028799003437	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1028799003438	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1028799003439	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1028799003440	generic binding surface II; other site
1028799003441	generic binding surface I; other site
1028799003442	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1028799003443	active site
1028799003444	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1028799003445	active site
1028799003446	catalytic site [active]
1028799003447	substrate binding site [chemical binding]; other site
1028799003448	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1028799003449	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1028799003450	Sm and related proteins; Region: Sm_like; cl00259
1028799003451	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1028799003452	putative oligomer interface [polypeptide binding]; other site
1028799003453	putative RNA binding site [nucleotide binding]; other site
1028799003454	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1028799003455	NusA N-terminal domain; Region: NusA_N; pfam08529
1028799003456	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1028799003457	RNA binding site [nucleotide binding]; other site
1028799003458	homodimer interface [polypeptide binding]; other site
1028799003459	NusA-like KH domain; Region: KH_5; pfam13184
1028799003460	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1028799003461	G-X-X-G motif; other site
1028799003462	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1028799003463	putative RNA binding cleft [nucleotide binding]; other site
1028799003464	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1028799003465	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1028799003466	translation initiation factor IF-2; Region: IF-2; TIGR00487
1028799003467	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1028799003468	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1028799003469	G1 box; other site
1028799003470	putative GEF interaction site [polypeptide binding]; other site
1028799003471	GTP/Mg2+ binding site [chemical binding]; other site
1028799003472	Switch I region; other site
1028799003473	G2 box; other site
1028799003474	G3 box; other site
1028799003475	Switch II region; other site
1028799003476	G4 box; other site
1028799003477	G5 box; other site
1028799003478	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1028799003479	Translation-initiation factor 2; Region: IF-2; pfam11987
1028799003480	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1028799003481	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1028799003482	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
1028799003483	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1028799003484	RNA binding site [nucleotide binding]; other site
1028799003485	active site
1028799003486	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
1028799003487	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1028799003488	active site
1028799003489	Riboflavin kinase; Region: Flavokinase; smart00904
1028799003490	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1028799003491	16S/18S rRNA binding site [nucleotide binding]; other site
1028799003492	S13e-L30e interaction site [polypeptide binding]; other site
1028799003493	25S rRNA binding site [nucleotide binding]; other site
1028799003494	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1028799003495	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1028799003496	RNase E interface [polypeptide binding]; other site
1028799003497	trimer interface [polypeptide binding]; other site
1028799003498	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1028799003499	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1028799003500	RNase E interface [polypeptide binding]; other site
1028799003501	trimer interface [polypeptide binding]; other site
1028799003502	active site
1028799003503	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1028799003504	putative nucleic acid binding region [nucleotide binding]; other site
1028799003505	G-X-X-G motif; other site
1028799003506	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1028799003507	RNA binding site [nucleotide binding]; other site
1028799003508	domain interface; other site
1028799003509	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1028799003510	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1028799003511	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1028799003512	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1028799003513	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1028799003514	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1028799003515	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1028799003516	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1028799003517	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1028799003518	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1028799003519	DNA-binding site [nucleotide binding]; DNA binding site
1028799003520	UTRA domain; Region: UTRA; pfam07702
1028799003521	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1028799003522	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1028799003523	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1028799003524	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1028799003525	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1028799003526	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1028799003527	classical (c) SDRs; Region: SDR_c; cd05233
1028799003528	NAD(P) binding site [chemical binding]; other site
1028799003529	active site
1028799003530	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1028799003531	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1028799003532	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1028799003533	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1028799003534	non-specific DNA binding site [nucleotide binding]; other site
1028799003535	salt bridge; other site
1028799003536	sequence-specific DNA binding site [nucleotide binding]; other site
1028799003537	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1028799003538	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1028799003539	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1028799003540	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1028799003541	putative MPT binding site; other site
1028799003542	recombinase A; Provisional; Region: recA; PRK09354
1028799003543	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1028799003544	hexamer interface [polypeptide binding]; other site
1028799003545	Walker A motif; other site
1028799003546	ATP binding site [chemical binding]; other site
1028799003547	Walker B motif; other site
1028799003548	phosphodiesterase; Provisional; Region: PRK12704
1028799003549	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1028799003550	Zn2+ binding site [ion binding]; other site
1028799003551	Mg2+ binding site [ion binding]; other site
1028799003552	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1028799003553	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1028799003554	putative active site [active]
1028799003555	metal binding site [ion binding]; metal-binding site
1028799003556	homodimer binding site [polypeptide binding]; other site
1028799003557	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1028799003558	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1028799003559	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1028799003560	dimer interface [polypeptide binding]; other site
1028799003561	PYR/PP interface [polypeptide binding]; other site
1028799003562	TPP binding site [chemical binding]; other site
1028799003563	substrate binding site [chemical binding]; other site
1028799003564	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1028799003565	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1028799003566	TPP-binding site [chemical binding]; other site
1028799003567	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1028799003568	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1028799003569	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1028799003570	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1028799003571	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799003572	FeS/SAM binding site; other site
1028799003573	TRAM domain; Region: TRAM; pfam01938
1028799003574	Predicted membrane protein [Function unknown]; Region: COG4550
1028799003575	Predicted membrane protein [Function unknown]; Region: COG4732
1028799003576	MutS domain I; Region: MutS_I; pfam01624
1028799003577	MutS domain II; Region: MutS_II; pfam05188
1028799003578	MutS domain III; Region: MutS_III; pfam05192
1028799003579	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
1028799003580	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1028799003581	Plasmid replication protein; Region: Rep_2; pfam01719
1028799003582	Plasmid replication protein; Region: Rep_2; pfam01719
1028799003583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1028799003584	Chloramphenicol acetyltransferase; Region: CAT; pfam00302
1028799003585	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
1028799003586	MutS domain II; Region: MutS_II; pfam05188
1028799003587	MutS domain III; Region: MutS_III; pfam05192
1028799003588	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
1028799003589	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1028799003590	Walker A/P-loop; other site
1028799003591	ATP binding site [chemical binding]; other site
1028799003592	Q-loop/lid; other site
1028799003593	ABC transporter signature motif; other site
1028799003594	Walker B; other site
1028799003595	D-loop; other site
1028799003596	H-loop/switch region; other site
1028799003597	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1028799003598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799003599	ATP binding site [chemical binding]; other site
1028799003600	Mg2+ binding site [ion binding]; other site
1028799003601	G-X-G motif; other site
1028799003602	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1028799003603	ATP binding site [chemical binding]; other site
1028799003604	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1028799003605	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
1028799003606	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1028799003607	amphipathic channel; other site
1028799003608	Asn-Pro-Ala signature motifs; other site
1028799003609	glycerol kinase; Provisional; Region: glpK; PRK00047
1028799003610	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1028799003611	N- and C-terminal domain interface [polypeptide binding]; other site
1028799003612	active site
1028799003613	MgATP binding site [chemical binding]; other site
1028799003614	catalytic site [active]
1028799003615	metal binding site [ion binding]; metal-binding site
1028799003616	glycerol binding site [chemical binding]; other site
1028799003617	homotetramer interface [polypeptide binding]; other site
1028799003618	homodimer interface [polypeptide binding]; other site
1028799003619	FBP binding site [chemical binding]; other site
1028799003620	protein IIAGlc interface [polypeptide binding]; other site
1028799003621	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1028799003622	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1028799003623	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1028799003624	Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209
1028799003625	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1028799003626	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1028799003627	bacterial Hfq-like; Region: Hfq; cd01716
1028799003628	hexamer interface [polypeptide binding]; other site
1028799003629	Sm1 motif; other site
1028799003630	RNA binding site [nucleotide binding]; other site
1028799003631	Sm2 motif; other site
1028799003632	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1028799003633	catalytic residues [active]
1028799003634	dimer interface [polypeptide binding]; other site
1028799003635	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1028799003636	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1028799003637	HflX GTPase family; Region: HflX; cd01878
1028799003638	G1 box; other site
1028799003639	GTP/Mg2+ binding site [chemical binding]; other site
1028799003640	Switch I region; other site
1028799003641	G2 box; other site
1028799003642	G3 box; other site
1028799003643	Switch II region; other site
1028799003644	G4 box; other site
1028799003645	G5 box; other site
1028799003646	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1028799003647	Aluminium resistance protein; Region: Alum_res; pfam06838
1028799003648	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1028799003649	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1028799003650	DNA binding residues [nucleotide binding]
1028799003651	putative dimer interface [polypeptide binding]; other site
1028799003652	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1028799003653	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1028799003654	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1028799003655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1028799003656	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1028799003657	Pathogenicity factor; Region: AvrE; pfam11725
1028799003658	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1028799003659	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1028799003660	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1028799003661	catalytic residue [active]
1028799003662	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1028799003663	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1028799003664	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1028799003665	putative active site [active]
1028799003666	catalytic site [active]
1028799003667	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1028799003668	putative active site [active]
1028799003669	catalytic site [active]
1028799003670	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1028799003671	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1028799003672	Walker A/P-loop; other site
1028799003673	ATP binding site [chemical binding]; other site
1028799003674	Q-loop/lid; other site
1028799003675	ABC transporter signature motif; other site
1028799003676	Walker B; other site
1028799003677	D-loop; other site
1028799003678	H-loop/switch region; other site
1028799003679	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1028799003680	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1028799003681	Histidine kinase; Region: HisKA_3; pfam07730
1028799003682	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1028799003683	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1028799003684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799003685	active site
1028799003686	phosphorylation site [posttranslational modification]
1028799003687	intermolecular recognition site; other site
1028799003688	dimerization interface [polypeptide binding]; other site
1028799003689	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1028799003690	DNA binding residues [nucleotide binding]
1028799003691	dimerization interface [polypeptide binding]; other site
1028799003692	Staphylococcal nuclease homologues; Region: SNc; smart00318
1028799003693	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1028799003694	Catalytic site; other site
1028799003695	AAA domain; Region: AAA_11; pfam13086
1028799003696	aspartate kinase; Reviewed; Region: PRK09034
1028799003697	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1028799003698	putative catalytic residues [active]
1028799003699	putative nucleotide binding site [chemical binding]; other site
1028799003700	putative aspartate binding site [chemical binding]; other site
1028799003701	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1028799003702	allosteric regulatory residue; other site
1028799003703	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1028799003704	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1028799003705	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1028799003706	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1028799003707	threonine synthase; Reviewed; Region: PRK06721
1028799003708	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1028799003709	homodimer interface [polypeptide binding]; other site
1028799003710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799003711	catalytic residue [active]
1028799003712	homoserine kinase; Provisional; Region: PRK01212
1028799003713	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1028799003714	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1028799003715	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799003716	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1028799003717	active site
1028799003718	motif I; other site
1028799003719	motif II; other site
1028799003720	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1028799003721	lysine transporter; Provisional; Region: PRK10836
1028799003722	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1028799003723	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1028799003724	tetramer interface [polypeptide binding]; other site
1028799003725	heme binding pocket [chemical binding]; other site
1028799003726	NADPH binding site [chemical binding]; other site
1028799003727	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1028799003728	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1028799003729	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1028799003730	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1028799003731	active site
1028799003732	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1028799003733	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1028799003734	LexA repressor; Validated; Region: PRK00215
1028799003735	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1028799003736	putative DNA binding site [nucleotide binding]; other site
1028799003737	putative Zn2+ binding site [ion binding]; other site
1028799003738	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1028799003739	Catalytic site [active]
1028799003740	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1028799003741	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1028799003742	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1028799003743	TPP-binding site [chemical binding]; other site
1028799003744	dimer interface [polypeptide binding]; other site
1028799003745	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1028799003746	PYR/PP interface [polypeptide binding]; other site
1028799003747	dimer interface [polypeptide binding]; other site
1028799003748	TPP binding site [chemical binding]; other site
1028799003749	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1028799003750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1028799003751	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
1028799003752	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1028799003753	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1028799003754	active site
1028799003755	metal binding site [ion binding]; metal-binding site
1028799003756	DNA binding site [nucleotide binding]
1028799003757	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1028799003758	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1028799003759	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1028799003760	Walker A/P-loop; other site
1028799003761	ATP binding site [chemical binding]; other site
1028799003762	Q-loop/lid; other site
1028799003763	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1028799003764	ABC transporter signature motif; other site
1028799003765	Walker B; other site
1028799003766	D-loop; other site
1028799003767	H-loop/switch region; other site
1028799003768	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1028799003769	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954
1028799003770	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1028799003771	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799003772	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799003773	aconitate hydratase; Validated; Region: PRK09277
1028799003774	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1028799003775	substrate binding site [chemical binding]; other site
1028799003776	ligand binding site [chemical binding]; other site
1028799003777	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1028799003778	substrate binding site [chemical binding]; other site
1028799003779	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1028799003780	active site
1028799003781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
1028799003782	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1028799003783	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1028799003784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799003785	ATP binding site [chemical binding]; other site
1028799003786	Mg2+ binding site [ion binding]; other site
1028799003787	G-X-G motif; other site
1028799003788	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1028799003789	anchoring element; other site
1028799003790	dimer interface [polypeptide binding]; other site
1028799003791	ATP binding site [chemical binding]; other site
1028799003792	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1028799003793	active site
1028799003794	putative metal-binding site [ion binding]; other site
1028799003795	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1028799003796	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1028799003797	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1028799003798	CAP-like domain; other site
1028799003799	active site
1028799003800	primary dimer interface [polypeptide binding]; other site
1028799003801	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1028799003802	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1028799003803	amino acid carrier protein; Region: agcS; TIGR00835
1028799003804	CAT RNA binding domain; Region: CAT_RBD; smart01061
1028799003805	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1028799003806	PRD domain; Region: PRD; pfam00874
1028799003807	PRD domain; Region: PRD; pfam00874
1028799003808	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1028799003809	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1028799003810	Predicted integral membrane protein [Function unknown]; Region: COG0392
1028799003811	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1028799003812	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1028799003813	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1028799003814	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1028799003815	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
1028799003816	active site 1 [active]
1028799003817	dimer interface [polypeptide binding]; other site
1028799003818	hexamer interface [polypeptide binding]; other site
1028799003819	active site 2 [active]
1028799003820	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1028799003821	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1028799003822	active site
1028799003823	DNA binding site [nucleotide binding]
1028799003824	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1028799003825	prephenate dehydrogenase; Validated; Region: PRK06545
1028799003826	prephenate dehydrogenase; Validated; Region: PRK08507
1028799003827	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1028799003828	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1028799003829	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1028799003830	putative oligomer interface [polypeptide binding]; other site
1028799003831	putative active site [active]
1028799003832	metal binding site [ion binding]; metal-binding site
1028799003833	anthranilate synthase component I; Provisional; Region: PRK13567
1028799003834	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1028799003835	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1028799003836	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1028799003837	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1028799003838	glutamine binding [chemical binding]; other site
1028799003839	catalytic triad [active]
1028799003840	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1028799003841	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1028799003842	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1028799003843	active site
1028799003844	ribulose/triose binding site [chemical binding]; other site
1028799003845	phosphate binding site [ion binding]; other site
1028799003846	substrate (anthranilate) binding pocket [chemical binding]; other site
1028799003847	product (indole) binding pocket [chemical binding]; other site
1028799003848	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1028799003849	active site
1028799003850	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1028799003851	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1028799003852	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799003853	catalytic residue [active]
1028799003854	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1028799003855	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1028799003856	substrate binding site [chemical binding]; other site
1028799003857	active site
1028799003858	catalytic residues [active]
1028799003859	heterodimer interface [polypeptide binding]; other site
1028799003860	FemAB family; Region: FemAB; pfam02388
1028799003861	FlxA-like protein; Region: FlxA; pfam14282
1028799003862	FemAB family; Region: FemAB; pfam02388
1028799003863	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1028799003864	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799003865	active site
1028799003866	motif I; other site
1028799003867	motif II; other site
1028799003868	SWIM zinc finger; Region: SWIM; pfam04434
1028799003869	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1028799003870	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799003871	Walker A/P-loop; other site
1028799003872	ATP binding site [chemical binding]; other site
1028799003873	Q-loop/lid; other site
1028799003874	ABC transporter signature motif; other site
1028799003875	Walker B; other site
1028799003876	D-loop; other site
1028799003877	H-loop/switch region; other site
1028799003878	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799003879	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1028799003880	Walker A/P-loop; other site
1028799003881	ATP binding site [chemical binding]; other site
1028799003882	Q-loop/lid; other site
1028799003883	ABC transporter signature motif; other site
1028799003884	Walker B; other site
1028799003885	D-loop; other site
1028799003886	H-loop/switch region; other site
1028799003887	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1028799003888	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799003889	dimer interface [polypeptide binding]; other site
1028799003890	conserved gate region; other site
1028799003891	putative PBP binding loops; other site
1028799003892	ABC-ATPase subunit interface; other site
1028799003893	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1028799003894	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799003895	dimer interface [polypeptide binding]; other site
1028799003896	conserved gate region; other site
1028799003897	putative PBP binding loops; other site
1028799003898	ABC-ATPase subunit interface; other site
1028799003899	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
1028799003900	oligoendopeptidase F; Region: pepF; TIGR00181
1028799003901	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1028799003902	active site
1028799003903	Zn binding site [ion binding]; other site
1028799003904	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1028799003905	PhoU domain; Region: PhoU; pfam01895
1028799003906	PhoU domain; Region: PhoU; pfam01895
1028799003907	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
1028799003908	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1028799003909	Walker A/P-loop; other site
1028799003910	ATP binding site [chemical binding]; other site
1028799003911	Q-loop/lid; other site
1028799003912	ABC transporter signature motif; other site
1028799003913	Walker B; other site
1028799003914	D-loop; other site
1028799003915	H-loop/switch region; other site
1028799003916	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1028799003917	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799003918	dimer interface [polypeptide binding]; other site
1028799003919	conserved gate region; other site
1028799003920	putative PBP binding loops; other site
1028799003921	ABC-ATPase subunit interface; other site
1028799003922	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1028799003923	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799003924	dimer interface [polypeptide binding]; other site
1028799003925	conserved gate region; other site
1028799003926	ABC-ATPase subunit interface; other site
1028799003927	phosphate binding protein; Region: ptsS_2; TIGR02136
1028799003928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1028799003929	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1028799003930	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1028799003931	S1 domain; Region: S1_2; pfam13509
1028799003932	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1028799003933	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1028799003934	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1028799003935	ABC transporter; Region: ABC_tran_2; pfam12848
1028799003936	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1028799003937	aspartate kinase; Reviewed; Region: PRK06635
1028799003938	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1028799003939	putative nucleotide binding site [chemical binding]; other site
1028799003940	putative catalytic residues [active]
1028799003941	putative Mg ion binding site [ion binding]; other site
1028799003942	putative aspartate binding site [chemical binding]; other site
1028799003943	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
1028799003944	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
1028799003945	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1028799003946	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1028799003947	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1028799003948	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1028799003949	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1028799003950	dimer interface [polypeptide binding]; other site
1028799003951	active site
1028799003952	catalytic residue [active]
1028799003953	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1028799003954	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1028799003955	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1028799003956	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1028799003957	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1028799003958	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1028799003959	active site
1028799003960	trimer interface [polypeptide binding]; other site
1028799003961	substrate binding site [chemical binding]; other site
1028799003962	CoA binding site [chemical binding]; other site
1028799003963	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1028799003964	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1028799003965	metal binding site [ion binding]; metal-binding site
1028799003966	dimer interface [polypeptide binding]; other site
1028799003967	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1028799003968	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1028799003969	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1028799003970	catalytic residue [active]
1028799003971	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1028799003972	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1028799003973	active site
1028799003974	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1028799003975	substrate binding site [chemical binding]; other site
1028799003976	catalytic residues [active]
1028799003977	dimer interface [polypeptide binding]; other site
1028799003978	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1028799003979	DNA-binding site [nucleotide binding]; DNA binding site
1028799003980	RNA-binding motif; other site
1028799003981	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699
1028799003982	acylphosphatase; Provisional; Region: PRK14431
1028799003983	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
1028799003984	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1028799003985	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1028799003986	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
1028799003987	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1028799003988	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1028799003989	metal ion-dependent adhesion site (MIDAS); other site
1028799003990	MoxR-like ATPases [General function prediction only]; Region: COG0714
1028799003991	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799003992	Walker A motif; other site
1028799003993	ATP binding site [chemical binding]; other site
1028799003994	Walker B motif; other site
1028799003995	arginine finger; other site
1028799003996	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1028799003997	active site
1028799003998	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1028799003999	active site
1028799004000	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1028799004001	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1028799004002	E3 interaction surface; other site
1028799004003	lipoyl attachment site [posttranslational modification]; other site
1028799004004	e3 binding domain; Region: E3_binding; pfam02817
1028799004005	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1028799004006	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1028799004007	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1028799004008	TPP-binding site [chemical binding]; other site
1028799004009	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
1028799004010	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1028799004011	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1028799004012	HAMP domain; Region: HAMP; pfam00672
1028799004013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1028799004014	dimer interface [polypeptide binding]; other site
1028799004015	phosphorylation site [posttranslational modification]
1028799004016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799004017	ATP binding site [chemical binding]; other site
1028799004018	Mg2+ binding site [ion binding]; other site
1028799004019	G-X-G motif; other site
1028799004020	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1028799004021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799004022	active site
1028799004023	phosphorylation site [posttranslational modification]
1028799004024	intermolecular recognition site; other site
1028799004025	dimerization interface [polypeptide binding]; other site
1028799004026	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1028799004027	DNA binding site [nucleotide binding]
1028799004028	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1028799004029	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1028799004030	active site
1028799004031	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1028799004032	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1028799004033	active site
1028799004034	homodimer interface [polypeptide binding]; other site
1028799004035	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799004036	Coenzyme A binding pocket [chemical binding]; other site
1028799004037	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1028799004038	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1028799004039	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1028799004040	protein binding site [polypeptide binding]; other site
1028799004041	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1028799004042	Catalytic dyad [active]
1028799004043	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1028799004044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479
1028799004045	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1028799004046	HPr interaction site; other site
1028799004047	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1028799004048	active site
1028799004049	phosphorylation site [posttranslational modification]
1028799004050	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1028799004051	SelR domain; Region: SelR; pfam01641
1028799004052	methionine sulfoxide reductase A; Provisional; Region: PRK13014
1028799004053	EDD domain protein, DegV family; Region: DegV; TIGR00762
1028799004054	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1028799004055	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1028799004056	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1028799004057	folate binding site [chemical binding]; other site
1028799004058	NADP+ binding site [chemical binding]; other site
1028799004059	thymidylate synthase; Region: thym_sym; TIGR03284
1028799004060	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1028799004061	dimerization interface [polypeptide binding]; other site
1028799004062	active site
1028799004063	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1028799004064	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1028799004065	Virulence factor; Region: Virulence_fact; pfam13769
1028799004066	HEAT repeats; Region: HEAT_2; pfam13646
1028799004067	HEAT repeat; Region: HEAT; pfam02985
1028799004068	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
1028799004069	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1028799004070	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1028799004071	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799004072	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1028799004073	RNA/DNA hybrid binding site [nucleotide binding]; other site
1028799004074	active site
1028799004075	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799004076	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
1028799004077	GA module; Region: GA; smart00844
1028799004078	GA module; Region: GA; smart00844
1028799004079	GA module; Region: GA; smart00844
1028799004080	GA module; Region: GA; smart00844
1028799004081	GA module; Region: GA; smart00844
1028799004082	GA module; Region: GA; smart00844
1028799004083	GA module; Region: GA; smart00844
1028799004084	GA module; Region: GA; smart00844
1028799004085	GA module; Region: GA; smart00844
1028799004086	GA module; Region: GA; smart00844
1028799004087	GA module; Region: GA; smart00844
1028799004088	GA module; Region: GA; smart00844
1028799004089	GA module; Region: GA; smart00844
1028799004090	GA module; Region: GA; smart00844
1028799004091	GA module; Region: GA; smart00844
1028799004092	GA module; Region: GA; smart00844
1028799004093	GA module; Region: GA; smart00844
1028799004094	GA module; Region: GA; pfam01468
1028799004095	GA module; Region: GA; smart00844
1028799004096	GA module; Region: GA; smart00844
1028799004097	GA module; Region: GA; smart00844
1028799004098	GA module; Region: GA; smart00844
1028799004099	GA module; Region: GA; pfam01468
1028799004100	GA module; Region: GA; smart00844
1028799004101	GA module; Region: GA; smart00844
1028799004102	GA module; Region: GA; smart00844
1028799004103	GA module; Region: GA; smart00844
1028799004104	GA module; Region: GA; smart00844
1028799004105	GA module; Region: GA; smart00844
1028799004106	GA module; Region: GA; smart00844
1028799004107	chromosome segregation protein; Provisional; Region: PRK02224
1028799004108	GA module; Region: GA; smart00844
1028799004109	GA module; Region: GA; smart00844
1028799004110	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1028799004111	GA module; Region: GA; smart00844
1028799004112	GA module; Region: GA; smart00844
1028799004113	GA module; Region: GA; smart00844
1028799004114	GA module; Region: GA; smart00844
1028799004115	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799004116	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799004117	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799004118	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799004119	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1028799004120	Amino acid permease; Region: AA_permease_2; pfam13520
1028799004121	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1028799004122	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1028799004123	tetramer interface [polypeptide binding]; other site
1028799004124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799004125	catalytic residue [active]
1028799004126	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1028799004127	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1028799004128	hexamer interface [polypeptide binding]; other site
1028799004129	ligand binding site [chemical binding]; other site
1028799004130	putative active site [active]
1028799004131	NAD(P) binding site [chemical binding]; other site
1028799004132	5'-3' exonuclease; Region: 53EXOc; smart00475
1028799004133	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1028799004134	active site
1028799004135	metal binding site 1 [ion binding]; metal-binding site
1028799004136	putative 5' ssDNA interaction site; other site
1028799004137	metal binding site 3; metal-binding site
1028799004138	metal binding site 2 [ion binding]; metal-binding site
1028799004139	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1028799004140	putative DNA binding site [nucleotide binding]; other site
1028799004141	putative metal binding site [ion binding]; other site
1028799004142	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1028799004143	Dynamin family; Region: Dynamin_N; pfam00350
1028799004144	G1 box; other site
1028799004145	GTP/Mg2+ binding site [chemical binding]; other site
1028799004146	G2 box; other site
1028799004147	Switch I region; other site
1028799004148	G3 box; other site
1028799004149	Switch II region; other site
1028799004150	G4 box; other site
1028799004151	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1028799004152	Dynamin family; Region: Dynamin_N; pfam00350
1028799004153	G1 box; other site
1028799004154	GTP/Mg2+ binding site [chemical binding]; other site
1028799004155	G2 box; other site
1028799004156	Switch I region; other site
1028799004157	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1028799004158	G3 box; other site
1028799004159	Switch II region; other site
1028799004160	GTP/Mg2+ binding site [chemical binding]; other site
1028799004161	G4 box; other site
1028799004162	G5 box; other site
1028799004163	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1028799004164	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1028799004165	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1028799004166	Cobalt transport protein component CbiN; Region: CbiN; cl00842
1028799004167	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1028799004168	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1028799004169	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1028799004170	cell division protein GpsB; Provisional; Region: PRK14127
1028799004171	DivIVA domain; Region: DivI1A_domain; TIGR03544
1028799004172	hypothetical protein; Provisional; Region: PRK13660
1028799004173	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
1028799004174	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1028799004175	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1028799004176	Transglycosylase; Region: Transgly; pfam00912
1028799004177	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1028799004178	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1028799004179	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1028799004180	minor groove reading motif; other site
1028799004181	helix-hairpin-helix signature motif; other site
1028799004182	substrate binding pocket [chemical binding]; other site
1028799004183	active site
1028799004184	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1028799004185	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1028799004186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
1028799004187	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1028799004188	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1028799004189	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1028799004190	putative dimer interface [polypeptide binding]; other site
1028799004191	putative anticodon binding site; other site
1028799004192	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1028799004193	homodimer interface [polypeptide binding]; other site
1028799004194	motif 1; other site
1028799004195	motif 2; other site
1028799004196	active site
1028799004197	motif 3; other site
1028799004198	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1028799004199	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1028799004200	active site
1028799004201	catalytic site [active]
1028799004202	substrate binding site [chemical binding]; other site
1028799004203	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1028799004204	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1028799004205	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1028799004206	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1028799004207	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1028799004208	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1028799004209	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1028799004210	active site
1028799004211	NTP binding site [chemical binding]; other site
1028799004212	metal binding triad [ion binding]; metal-binding site
1028799004213	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1028799004214	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1028799004215	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1028799004216	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1028799004217	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1028799004218	homodimer interface [polypeptide binding]; other site
1028799004219	metal binding site [ion binding]; metal-binding site
1028799004220	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1028799004221	Predicted membrane protein [Function unknown]; Region: COG4347
1028799004222	Uncharacterized conserved protein [Function unknown]; Region: COG5582
1028799004223	UPF0302 domain; Region: UPF0302; pfam08864
1028799004224	A short protein domain of unknown function; Region: IDEAL; smart00914
1028799004225	TPR repeat; Region: TPR_11; pfam13414
1028799004226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1028799004227	binding surface
1028799004228	TPR motif; other site
1028799004229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1028799004230	TPR motif; other site
1028799004231	binding surface
1028799004232	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1028799004233	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1028799004234	hinge; other site
1028799004235	active site
1028799004236	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1028799004237	active site
1028799004238	NAD binding site [chemical binding]; other site
1028799004239	metal binding site [ion binding]; metal-binding site
1028799004240	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1028799004241	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1028799004242	Tetramer interface [polypeptide binding]; other site
1028799004243	active site
1028799004244	FMN-binding site [chemical binding]; other site
1028799004245	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1028799004246	active site
1028799004247	multimer interface [polypeptide binding]; other site
1028799004248	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1028799004249	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1028799004250	substrate binding pocket [chemical binding]; other site
1028799004251	chain length determination region; other site
1028799004252	substrate-Mg2+ binding site; other site
1028799004253	catalytic residues [active]
1028799004254	aspartate-rich region 1; other site
1028799004255	active site lid residues [active]
1028799004256	aspartate-rich region 2; other site
1028799004257	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1028799004258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799004259	S-adenosylmethionine binding site [chemical binding]; other site
1028799004260	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1028799004261	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1028799004262	IHF dimer interface [polypeptide binding]; other site
1028799004263	IHF - DNA interface [nucleotide binding]; other site
1028799004264	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1028799004265	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1028799004266	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1028799004267	GTP-binding protein Der; Reviewed; Region: PRK00093
1028799004268	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1028799004269	G1 box; other site
1028799004270	GTP/Mg2+ binding site [chemical binding]; other site
1028799004271	Switch I region; other site
1028799004272	G2 box; other site
1028799004273	Switch II region; other site
1028799004274	G3 box; other site
1028799004275	G4 box; other site
1028799004276	G5 box; other site
1028799004277	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1028799004278	G1 box; other site
1028799004279	GTP/Mg2+ binding site [chemical binding]; other site
1028799004280	Switch I region; other site
1028799004281	G2 box; other site
1028799004282	G3 box; other site
1028799004283	Switch II region; other site
1028799004284	G4 box; other site
1028799004285	G5 box; other site
1028799004286	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1028799004287	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1028799004288	RNA binding site [nucleotide binding]; other site
1028799004289	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1028799004290	RNA binding site [nucleotide binding]; other site
1028799004291	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1028799004292	RNA binding site [nucleotide binding]; other site
1028799004293	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1028799004294	RNA binding site [nucleotide binding]; other site
1028799004295	cytidylate kinase; Provisional; Region: cmk; PRK00023
1028799004296	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1028799004297	CMP-binding site; other site
1028799004298	The sites determining sugar specificity; other site
1028799004299	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1028799004300	active site
1028799004301	homotetramer interface [polypeptide binding]; other site
1028799004302	homodimer interface [polypeptide binding]; other site
1028799004303	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1028799004304	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1028799004305	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799004306	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1028799004307	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1028799004308	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1028799004309	ATP binding site [chemical binding]; other site
1028799004310	putative Mg++ binding site [ion binding]; other site
1028799004311	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1028799004312	nucleotide binding region [chemical binding]; other site
1028799004313	ATP-binding site [chemical binding]; other site
1028799004314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1028799004315	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1028799004316	Predicted membrane protein [Function unknown]; Region: COG3601
1028799004317	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1028799004318	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1028799004319	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1028799004320	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1028799004321	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1028799004322	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1028799004323	dimerization interface [polypeptide binding]; other site
1028799004324	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1028799004325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1028799004326	dimer interface [polypeptide binding]; other site
1028799004327	phosphorylation site [posttranslational modification]
1028799004328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799004329	ATP binding site [chemical binding]; other site
1028799004330	Mg2+ binding site [ion binding]; other site
1028799004331	G-X-G motif; other site
1028799004332	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1028799004333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799004334	active site
1028799004335	phosphorylation site [posttranslational modification]
1028799004336	intermolecular recognition site; other site
1028799004337	dimerization interface [polypeptide binding]; other site
1028799004338	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1028799004339	DNA binding site [nucleotide binding]
1028799004340	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1028799004341	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1028799004342	RNA binding surface [nucleotide binding]; other site
1028799004343	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1028799004344	active site
1028799004345	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1028799004346	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1028799004347	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
1028799004348	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1028799004349	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1028799004350	active site
1028799004351	Int/Topo IB signature motif; other site
1028799004352	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1028799004353	metal binding site 2 [ion binding]; metal-binding site
1028799004354	putative DNA binding helix; other site
1028799004355	metal binding site 1 [ion binding]; metal-binding site
1028799004356	dimer interface [polypeptide binding]; other site
1028799004357	structural Zn2+ binding site [ion binding]; other site
1028799004358	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1028799004359	dimer interface [polypeptide binding]; other site
1028799004360	ADP-ribose binding site [chemical binding]; other site
1028799004361	active site
1028799004362	nudix motif; other site
1028799004363	metal binding site [ion binding]; metal-binding site
1028799004364	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1028799004365	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1028799004366	active site
1028799004367	catalytic tetrad [active]
1028799004368	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1028799004369	classical (c) SDRs; Region: SDR_c; cd05233
1028799004370	NAD(P) binding site [chemical binding]; other site
1028799004371	active site
1028799004372	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1028799004373	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1028799004374	ribonuclease Z; Region: RNase_Z; TIGR02651
1028799004375	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1028799004376	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1028799004377	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1028799004378	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1028799004379	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1028799004380	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1028799004381	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1028799004382	Ca binding site [ion binding]; other site
1028799004383	active site
1028799004384	catalytic site [active]
1028799004385	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1028799004386	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1028799004387	DNA binding site [nucleotide binding]
1028799004388	domain linker motif; other site
1028799004389	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1028799004390	putative ligand binding site [chemical binding]; other site
1028799004391	putative dimerization interface [polypeptide binding]; other site
1028799004392	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1028799004393	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1028799004394	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1028799004395	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1028799004396	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1028799004397	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1028799004398	peptidase T-like protein; Region: PepT-like; TIGR01883
1028799004399	metal binding site [ion binding]; metal-binding site
1028799004400	putative dimer interface [polypeptide binding]; other site
1028799004401	Predicted membrane protein [Function unknown]; Region: COG4129
1028799004402	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1028799004403	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1028799004404	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1028799004405	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1028799004406	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1028799004407	E3 interaction surface; other site
1028799004408	lipoyl attachment site [posttranslational modification]; other site
1028799004409	e3 binding domain; Region: E3_binding; pfam02817
1028799004410	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1028799004411	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1028799004412	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1028799004413	alpha subunit interface [polypeptide binding]; other site
1028799004414	TPP binding site [chemical binding]; other site
1028799004415	heterodimer interface [polypeptide binding]; other site
1028799004416	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1028799004417	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1028799004418	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1028799004419	tetramer interface [polypeptide binding]; other site
1028799004420	TPP-binding site [chemical binding]; other site
1028799004421	heterodimer interface [polypeptide binding]; other site
1028799004422	phosphorylation loop region [posttranslational modification]
1028799004423	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1028799004424	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1028799004425	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799004426	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1028799004427	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1028799004428	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1028799004429	Walker A/P-loop; other site
1028799004430	ATP binding site [chemical binding]; other site
1028799004431	Q-loop/lid; other site
1028799004432	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1028799004433	ABC transporter signature motif; other site
1028799004434	Walker B; other site
1028799004435	D-loop; other site
1028799004436	H-loop/switch region; other site
1028799004437	arginine repressor; Provisional; Region: PRK04280
1028799004438	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1028799004439	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1028799004440	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1028799004441	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1028799004442	substrate binding pocket [chemical binding]; other site
1028799004443	chain length determination region; other site
1028799004444	substrate-Mg2+ binding site; other site
1028799004445	catalytic residues [active]
1028799004446	aspartate-rich region 1; other site
1028799004447	active site lid residues [active]
1028799004448	aspartate-rich region 2; other site
1028799004449	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
1028799004450	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1028799004451	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1028799004452	generic binding surface II; other site
1028799004453	generic binding surface I; other site
1028799004454	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1028799004455	putative RNA binding site [nucleotide binding]; other site
1028799004456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1028799004457	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1028799004458	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1028799004459	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1028799004460	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1028799004461	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1028799004462	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1028799004463	carboxyltransferase (CT) interaction site; other site
1028799004464	biotinylation site [posttranslational modification]; other site
1028799004465	elongation factor P; Validated; Region: PRK00529
1028799004466	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1028799004467	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1028799004468	RNA binding site [nucleotide binding]; other site
1028799004469	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1028799004470	RNA binding site [nucleotide binding]; other site
1028799004471	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1028799004472	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1028799004473	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1028799004474	active site
1028799004475	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1028799004476	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1028799004477	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1028799004478	active site residue [active]
1028799004479	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1028799004480	tetramer interface [polypeptide binding]; other site
1028799004481	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799004482	catalytic residue [active]
1028799004483	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1028799004484	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1028799004485	tetramer interface [polypeptide binding]; other site
1028799004486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799004487	catalytic residue [active]
1028799004488	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1028799004489	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1028799004490	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1028799004491	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1028799004492	ADP binding site [chemical binding]; other site
1028799004493	magnesium binding site [ion binding]; other site
1028799004494	putative shikimate binding site; other site
1028799004495	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1028799004496	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1028799004497	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1028799004498	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1028799004499	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1028799004500	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1028799004501	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1028799004502	Type II/IV secretion system protein; Region: T2SE; pfam00437
1028799004503	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1028799004504	Walker A motif; other site
1028799004505	ATP binding site [chemical binding]; other site
1028799004506	Walker B motif; other site
1028799004507	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1028799004508	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1028799004509	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1028799004510	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1028799004511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
1028799004512	Rhomboid family; Region: Rhomboid; pfam01694
1028799004513	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1028799004514	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1028799004515	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1028799004516	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1028799004517	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1028799004518	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1028799004519	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1028799004520	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1028799004521	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1028799004522	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1028799004523	metal binding site 2 [ion binding]; metal-binding site
1028799004524	putative DNA binding helix; other site
1028799004525	metal binding site 1 [ion binding]; metal-binding site
1028799004526	dimer interface [polypeptide binding]; other site
1028799004527	structural Zn2+ binding site [ion binding]; other site
1028799004528	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1028799004529	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799004530	ABC-ATPase subunit  interface; other site
1028799004531	dimer interface [polypeptide binding]; other site
1028799004532	putative PBP binding regions; other site
1028799004533	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1028799004534	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1028799004535	endonuclease IV; Provisional; Region: PRK01060
1028799004536	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1028799004537	AP (apurinic/apyrimidinic) site pocket; other site
1028799004538	DNA interaction; other site
1028799004539	Metal-binding active site; metal-binding site
1028799004540	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1028799004541	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1028799004542	ATP binding site [chemical binding]; other site
1028799004543	Mg++ binding site [ion binding]; other site
1028799004544	motif III; other site
1028799004545	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1028799004546	nucleotide binding region [chemical binding]; other site
1028799004547	ATP-binding site [chemical binding]; other site
1028799004548	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1028799004549	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1028799004550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1028799004551	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1028799004552	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1028799004553	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1028799004554	Family of unknown function (DUF633); Region: DUF633; pfam04816
1028799004555	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1028799004556	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1028799004557	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1028799004558	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1028799004559	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1028799004560	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1028799004561	DNA binding residues [nucleotide binding]
1028799004562	DNA primase, catalytic core; Region: dnaG; TIGR01391
1028799004563	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1028799004564	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1028799004565	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1028799004566	active site
1028799004567	metal binding site [ion binding]; metal-binding site
1028799004568	interdomain interaction site; other site
1028799004569	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
1028799004570	HTH domain; Region: HTH_11; cl17392
1028799004571	FOG: CBS domain [General function prediction only]; Region: COG0517
1028799004572	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1028799004573	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1028799004574	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1028799004575	motif 1; other site
1028799004576	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1028799004577	active site
1028799004578	motif 2; other site
1028799004579	motif 3; other site
1028799004580	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1028799004581	anticodon binding site; other site
1028799004582	DNA repair protein RecO; Region: reco; TIGR00613
1028799004583	Recombination protein O N terminal; Region: RecO_N; pfam11967
1028799004584	Recombination protein O C terminal; Region: RecO_C; pfam02565
1028799004585	GTPase Era; Reviewed; Region: era; PRK00089
1028799004586	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1028799004587	G1 box; other site
1028799004588	GTP/Mg2+ binding site [chemical binding]; other site
1028799004589	Switch I region; other site
1028799004590	G2 box; other site
1028799004591	Switch II region; other site
1028799004592	G3 box; other site
1028799004593	G4 box; other site
1028799004594	G5 box; other site
1028799004595	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1028799004596	active site
1028799004597	catalytic motif [active]
1028799004598	Zn binding site [ion binding]; other site
1028799004599	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1028799004600	metal-binding heat shock protein; Provisional; Region: PRK00016
1028799004601	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1028799004602	PhoH-like protein; Region: PhoH; pfam02562
1028799004603	hypothetical protein; Provisional; Region: PRK13665
1028799004604	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1028799004605	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1028799004606	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1028799004607	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1028799004608	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799004609	FeS/SAM binding site; other site
1028799004610	TRAM domain; Region: TRAM; cl01282
1028799004611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1028799004612	RNA methyltransferase, RsmE family; Region: TIGR00046
1028799004613	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1028799004614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799004615	S-adenosylmethionine binding site [chemical binding]; other site
1028799004616	chaperone protein DnaJ; Provisional; Region: PRK14280
1028799004617	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1028799004618	HSP70 interaction site [polypeptide binding]; other site
1028799004619	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1028799004620	substrate binding site [polypeptide binding]; other site
1028799004621	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1028799004622	Zn binding sites [ion binding]; other site
1028799004623	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1028799004624	dimer interface [polypeptide binding]; other site
1028799004625	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1028799004626	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1028799004627	nucleotide binding site [chemical binding]; other site
1028799004628	NEF interaction site [polypeptide binding]; other site
1028799004629	SBD interface [polypeptide binding]; other site
1028799004630	heat shock protein GrpE; Provisional; Region: PRK14140
1028799004631	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1028799004632	dimer interface [polypeptide binding]; other site
1028799004633	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1028799004634	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1028799004635	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
1028799004636	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
1028799004637	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1028799004638	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799004639	FeS/SAM binding site; other site
1028799004640	HemN C-terminal domain; Region: HemN_C; pfam06969
1028799004641	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799004642	GTP-binding protein LepA; Provisional; Region: PRK05433
1028799004643	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1028799004644	G1 box; other site
1028799004645	putative GEF interaction site [polypeptide binding]; other site
1028799004646	GTP/Mg2+ binding site [chemical binding]; other site
1028799004647	Switch I region; other site
1028799004648	G2 box; other site
1028799004649	G3 box; other site
1028799004650	Switch II region; other site
1028799004651	G4 box; other site
1028799004652	G5 box; other site
1028799004653	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1028799004654	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1028799004655	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1028799004656	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1028799004657	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1028799004658	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1028799004659	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1028799004660	Competence protein; Region: Competence; pfam03772
1028799004661	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1028799004662	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1028799004663	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1028799004664	catalytic motif [active]
1028799004665	Zn binding site [ion binding]; other site
1028799004666	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1028799004667	SLBB domain; Region: SLBB; pfam10531
1028799004668	Helix-hairpin-helix motif; Region: HHH; pfam00633
1028799004669	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1028799004670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799004671	S-adenosylmethionine binding site [chemical binding]; other site
1028799004672	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1028799004673	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1028799004674	Zn2+ binding site [ion binding]; other site
1028799004675	Mg2+ binding site [ion binding]; other site
1028799004676	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1028799004677	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
1028799004678	active site
1028799004679	(T/H)XGH motif; other site
1028799004680	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1028799004681	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1028799004682	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1028799004683	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1028799004684	shikimate binding site; other site
1028799004685	NAD(P) binding site [chemical binding]; other site
1028799004686	GTPase YqeH; Provisional; Region: PRK13796
1028799004687	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1028799004688	GTP/Mg2+ binding site [chemical binding]; other site
1028799004689	G4 box; other site
1028799004690	G5 box; other site
1028799004691	G1 box; other site
1028799004692	Switch I region; other site
1028799004693	G2 box; other site
1028799004694	G3 box; other site
1028799004695	Switch II region; other site
1028799004696	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1028799004697	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799004698	active site
1028799004699	motif I; other site
1028799004700	motif II; other site
1028799004701	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1028799004702	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1028799004703	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1028799004704	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1028799004705	Fic family protein [Function unknown]; Region: COG3177
1028799004706	Fic/DOC family; Region: Fic; pfam02661
1028799004707	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1028799004708	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1028799004709	putative active site [active]
1028799004710	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1028799004711	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1028799004712	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1028799004713	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1028799004714	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1028799004715	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1028799004716	carboxyltransferase (CT) interaction site; other site
1028799004717	biotinylation site [posttranslational modification]; other site
1028799004718	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1028799004719	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1028799004720	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1028799004721	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1028799004722	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1028799004723	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1028799004724	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1028799004725	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1028799004726	Sugar specificity; other site
1028799004727	Pyrimidine base specificity; other site
1028799004728	ATP-binding site [chemical binding]; other site
1028799004729	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1028799004730	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1028799004731	Peptidase family U32; Region: Peptidase_U32; pfam01136
1028799004732	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1028799004733	Peptidase family U32; Region: Peptidase_U32; pfam01136
1028799004734	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1028799004735	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799004736	S-adenosylmethionine binding site [chemical binding]; other site
1028799004737	hypothetical protein; Provisional; Region: PRK13678
1028799004738	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
1028799004739	hypothetical protein; Provisional; Region: PRK05473
1028799004740	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1028799004741	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1028799004742	motif 1; other site
1028799004743	active site
1028799004744	motif 2; other site
1028799004745	motif 3; other site
1028799004746	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1028799004747	DHHA1 domain; Region: DHHA1; pfam02272
1028799004748	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1028799004749	AAA domain; Region: AAA_30; pfam13604
1028799004750	Family description; Region: UvrD_C_2; pfam13538
1028799004751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1028799004752	binding surface
1028799004753	TPR motif; other site
1028799004754	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1028799004755	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1028799004756	binding surface
1028799004757	TPR motif; other site
1028799004758	TPR repeat; Region: TPR_11; pfam13414
1028799004759	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1028799004760	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1028799004761	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1028799004762	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1028799004763	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1028799004764	catalytic residue [active]
1028799004765	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1028799004766	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1028799004767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1028799004768	Predicted transcriptional regulator [Transcription]; Region: COG1959
1028799004769	Transcriptional regulator; Region: Rrf2; pfam02082
1028799004770	recombination factor protein RarA; Reviewed; Region: PRK13342
1028799004771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799004772	Walker A motif; other site
1028799004773	ATP binding site [chemical binding]; other site
1028799004774	Walker B motif; other site
1028799004775	arginine finger; other site
1028799004776	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1028799004777	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1028799004778	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1028799004779	putative ATP binding site [chemical binding]; other site
1028799004780	putative substrate interface [chemical binding]; other site
1028799004781	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1028799004782	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1028799004783	dimer interface [polypeptide binding]; other site
1028799004784	anticodon binding site; other site
1028799004785	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1028799004786	homodimer interface [polypeptide binding]; other site
1028799004787	motif 1; other site
1028799004788	active site
1028799004789	motif 2; other site
1028799004790	GAD domain; Region: GAD; pfam02938
1028799004791	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1028799004792	motif 3; other site
1028799004793	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1028799004794	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1028799004795	dimer interface [polypeptide binding]; other site
1028799004796	motif 1; other site
1028799004797	active site
1028799004798	motif 2; other site
1028799004799	motif 3; other site
1028799004800	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1028799004801	anticodon binding site; other site
1028799004802	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1028799004803	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1028799004804	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1028799004805	active site
1028799004806	metal binding site [ion binding]; metal-binding site
1028799004807	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1028799004808	putative active site [active]
1028799004809	dimerization interface [polypeptide binding]; other site
1028799004810	putative tRNAtyr binding site [nucleotide binding]; other site
1028799004811	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1028799004812	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1028799004813	Zn2+ binding site [ion binding]; other site
1028799004814	Mg2+ binding site [ion binding]; other site
1028799004815	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1028799004816	synthetase active site [active]
1028799004817	NTP binding site [chemical binding]; other site
1028799004818	metal binding site [ion binding]; metal-binding site
1028799004819	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1028799004820	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1028799004821	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1028799004822	active site
1028799004823	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1028799004824	DHH family; Region: DHH; pfam01368
1028799004825	DHHA1 domain; Region: DHHA1; pfam02272
1028799004826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1028799004827	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1028799004828	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1028799004829	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1028799004830	Protein export membrane protein; Region: SecD_SecF; pfam02355
1028799004831	Preprotein translocase subunit; Region: YajC; pfam02699
1028799004832	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1028799004833	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1028799004834	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1028799004835	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1028799004836	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1028799004837	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799004838	Walker A motif; other site
1028799004839	ATP binding site [chemical binding]; other site
1028799004840	Walker B motif; other site
1028799004841	arginine finger; other site
1028799004842	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1028799004843	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1028799004844	RuvA N terminal domain; Region: RuvA_N; pfam01330
1028799004845	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1028799004846	ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492
1028799004847	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1028799004848	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1028799004849	GTP1/OBG; Region: GTP1_OBG; pfam01018
1028799004850	Obg GTPase; Region: Obg; cd01898
1028799004851	G1 box; other site
1028799004852	GTP/Mg2+ binding site [chemical binding]; other site
1028799004853	Switch I region; other site
1028799004854	G2 box; other site
1028799004855	G3 box; other site
1028799004856	Switch II region; other site
1028799004857	G4 box; other site
1028799004858	G5 box; other site
1028799004859	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1028799004860	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1028799004861	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
1028799004862	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1028799004863	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1028799004864	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1028799004865	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
1028799004866	rod shape-determining protein MreC; Region: MreC; pfam04085
1028799004867	hypothetical protein; Reviewed; Region: PRK00024
1028799004868	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1028799004869	MPN+ (JAMM) motif; other site
1028799004870	Zinc-binding site [ion binding]; other site
1028799004871	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1028799004872	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1028799004873	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1028799004874	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1028799004875	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1028799004876	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1028799004877	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1028799004878	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1028799004879	active site
1028799004880	HIGH motif; other site
1028799004881	nucleotide binding site [chemical binding]; other site
1028799004882	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1028799004883	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1028799004884	active site
1028799004885	KMSKS motif; other site
1028799004886	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1028799004887	tRNA binding surface [nucleotide binding]; other site
1028799004888	anticodon binding site; other site
1028799004889	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1028799004890	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1028799004891	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1028799004892	Putative ammonia monooxygenase; Region: AmoA; pfam05145
1028799004893	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1028799004894	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1028799004895	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1028799004896	inhibitor-cofactor binding pocket; inhibition site
1028799004897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799004898	catalytic residue [active]
1028799004899	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1028799004900	dimer interface [polypeptide binding]; other site
1028799004901	active site
1028799004902	Schiff base residues; other site
1028799004903	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1028799004904	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1028799004905	active site
1028799004906	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1028799004907	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1028799004908	domain interfaces; other site
1028799004909	active site
1028799004910	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
1028799004911	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1028799004912	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1028799004913	tRNA; other site
1028799004914	putative tRNA binding site [nucleotide binding]; other site
1028799004915	putative NADP binding site [chemical binding]; other site
1028799004916	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1028799004917	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1028799004918	G1 box; other site
1028799004919	GTP/Mg2+ binding site [chemical binding]; other site
1028799004920	Switch I region; other site
1028799004921	G2 box; other site
1028799004922	G3 box; other site
1028799004923	Switch II region; other site
1028799004924	G4 box; other site
1028799004925	G5 box; other site
1028799004926	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1028799004927	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1028799004928	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799004929	Walker A motif; other site
1028799004930	ATP binding site [chemical binding]; other site
1028799004931	Walker B motif; other site
1028799004932	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1028799004933	trigger factor; Provisional; Region: tig; PRK01490
1028799004934	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1028799004935	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1028799004936	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
1028799004937	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1028799004938	23S rRNA binding site [nucleotide binding]; other site
1028799004939	L21 binding site [polypeptide binding]; other site
1028799004940	L13 binding site [polypeptide binding]; other site
1028799004941	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1028799004942	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1028799004943	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1028799004944	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1028799004945	lysine transporter; Provisional; Region: PRK10836
1028799004946	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1028799004947	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1028799004948	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1028799004949	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1028799004950	active site
1028799004951	dimer interface [polypeptide binding]; other site
1028799004952	motif 1; other site
1028799004953	motif 2; other site
1028799004954	motif 3; other site
1028799004955	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1028799004956	anticodon binding site; other site
1028799004957	primosomal protein DnaI; Reviewed; Region: PRK08939
1028799004958	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1028799004959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799004960	Walker A motif; other site
1028799004961	ATP binding site [chemical binding]; other site
1028799004962	Walker B motif; other site
1028799004963	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1028799004964	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1028799004965	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1028799004966	ATP cone domain; Region: ATP-cone; pfam03477
1028799004967	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
1028799004968	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1028799004969	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1028799004970	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1028799004971	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1028799004972	CoA-binding site [chemical binding]; other site
1028799004973	ATP-binding [chemical binding]; other site
1028799004974	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1028799004975	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1028799004976	DNA binding site [nucleotide binding]
1028799004977	catalytic residue [active]
1028799004978	H2TH interface [polypeptide binding]; other site
1028799004979	putative catalytic residues [active]
1028799004980	turnover-facilitating residue; other site
1028799004981	intercalation triad [nucleotide binding]; other site
1028799004982	8OG recognition residue [nucleotide binding]; other site
1028799004983	putative reading head residues; other site
1028799004984	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1028799004985	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1028799004986	DNA polymerase I; Provisional; Region: PRK05755
1028799004987	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1028799004988	active site
1028799004989	metal binding site 1 [ion binding]; metal-binding site
1028799004990	putative 5' ssDNA interaction site; other site
1028799004991	metal binding site 3; metal-binding site
1028799004992	metal binding site 2 [ion binding]; metal-binding site
1028799004993	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1028799004994	putative DNA binding site [nucleotide binding]; other site
1028799004995	putative metal binding site [ion binding]; other site
1028799004996	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1028799004997	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1028799004998	active site
1028799004999	DNA binding site [nucleotide binding]
1028799005000	catalytic site [active]
1028799005001	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1028799005002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1028799005003	dimer interface [polypeptide binding]; other site
1028799005004	phosphorylation site [posttranslational modification]
1028799005005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799005006	ATP binding site [chemical binding]; other site
1028799005007	Mg2+ binding site [ion binding]; other site
1028799005008	G-X-G motif; other site
1028799005009	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1028799005010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799005011	active site
1028799005012	phosphorylation site [posttranslational modification]
1028799005013	intermolecular recognition site; other site
1028799005014	dimerization interface [polypeptide binding]; other site
1028799005015	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1028799005016	DNA binding site [nucleotide binding]
1028799005017	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1028799005018	isocitrate dehydrogenase; Validated; Region: PRK07362
1028799005019	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1028799005020	Citrate synthase; Region: Citrate_synt; pfam00285
1028799005021	dimer interface [polypeptide binding]; other site
1028799005022	active site
1028799005023	oxalacetate/citrate binding site [chemical binding]; other site
1028799005024	citrylCoA binding site [chemical binding]; other site
1028799005025	coenzyme A binding site [chemical binding]; other site
1028799005026	catalytic triad [active]
1028799005027	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1028799005028	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1028799005029	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1028799005030	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1028799005031	pyruvate kinase; Provisional; Region: PRK06354
1028799005032	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1028799005033	domain interfaces; other site
1028799005034	active site
1028799005035	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1028799005036	6-phosphofructokinase; Provisional; Region: PRK03202
1028799005037	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1028799005038	active site
1028799005039	ADP/pyrophosphate binding site [chemical binding]; other site
1028799005040	dimerization interface [polypeptide binding]; other site
1028799005041	allosteric effector site; other site
1028799005042	fructose-1,6-bisphosphate binding site; other site
1028799005043	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1028799005044	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1028799005045	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1028799005046	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1028799005047	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1028799005048	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1028799005049	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1028799005050	putative NAD(P) binding site [chemical binding]; other site
1028799005051	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1028799005052	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1028799005053	active site
1028799005054	PHP Thumb interface [polypeptide binding]; other site
1028799005055	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1028799005056	generic binding surface I; other site
1028799005057	generic binding surface II; other site
1028799005058	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1028799005059	DHH family; Region: DHH; pfam01368
1028799005060	DHHA1 domain; Region: DHHA1; pfam02272
1028799005061	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1028799005062	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1028799005063	DNA-binding site [nucleotide binding]; DNA binding site
1028799005064	DRTGG domain; Region: DRTGG; pfam07085
1028799005065	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1028799005066	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1028799005067	active site 2 [active]
1028799005068	active site 1 [active]
1028799005069	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1028799005070	Ligand Binding Site [chemical binding]; other site
1028799005071	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1028799005072	metal-dependent hydrolase; Provisional; Region: PRK00685
1028799005073	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1028799005074	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1028799005075	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1028799005076	active site
1028799005077	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1028799005078	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1028799005079	hexamer interface [polypeptide binding]; other site
1028799005080	ligand binding site [chemical binding]; other site
1028799005081	putative active site [active]
1028799005082	NAD(P) binding site [chemical binding]; other site
1028799005083	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1028799005084	Ligand Binding Site [chemical binding]; other site
1028799005085	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1028799005086	propionate/acetate kinase; Provisional; Region: PRK12379
1028799005087	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1028799005088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799005089	S-adenosylmethionine binding site [chemical binding]; other site
1028799005090	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1028799005091	dimer interface [polypeptide binding]; other site
1028799005092	catalytic triad [active]
1028799005093	peroxidatic and resolving cysteines [active]
1028799005094	hypothetical protein; Provisional; Region: PRK10621
1028799005095	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1028799005096	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1028799005097	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1028799005098	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1028799005099	Ligand Binding Site [chemical binding]; other site
1028799005100	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1028799005101	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1028799005102	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1028799005103	catalytic residue [active]
1028799005104	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
1028799005105	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1028799005106	GAF domain; Region: GAF_2; pfam13185
1028799005107	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1028799005108	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1028799005109	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1028799005110	RNA binding surface [nucleotide binding]; other site
1028799005111	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1028799005112	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1028799005113	active site
1028799005114	catalytic site [active]
1028799005115	OsmC-like protein; Region: OsmC; cl00767
1028799005116	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1028799005117	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1028799005118	catalytic residue [active]
1028799005119	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
1028799005120	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1028799005121	ligand binding site [chemical binding]; other site
1028799005122	NAD binding site [chemical binding]; other site
1028799005123	dimerization interface [polypeptide binding]; other site
1028799005124	catalytic site [active]
1028799005125	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1028799005126	putative L-serine binding site [chemical binding]; other site
1028799005127	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1028799005128	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799005129	motif II; other site
1028799005130	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1028799005131	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1028799005132	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1028799005133	active site turn [active]
1028799005134	phosphorylation site [posttranslational modification]
1028799005135	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1028799005136	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1028799005137	putative acyl-acceptor binding pocket; other site
1028799005138	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1028799005139	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1028799005140	protein binding site [polypeptide binding]; other site
1028799005141	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1028799005142	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1028799005143	active site
1028799005144	HIGH motif; other site
1028799005145	dimer interface [polypeptide binding]; other site
1028799005146	KMSKS motif; other site
1028799005147	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1028799005148	RNA binding surface [nucleotide binding]; other site
1028799005149	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1028799005150	Transglycosylase; Region: Transgly; pfam00912
1028799005151	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
1028799005152	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1028799005153	NEAr Transporter domain; Region: NEAT; smart00725
1028799005154	NEAr Transporter domain; Region: NEAT; smart00725
1028799005155	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1028799005156	heme-binding site [chemical binding]; other site
1028799005157	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1028799005158	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1028799005159	Potassium binding sites [ion binding]; other site
1028799005160	Cesium cation binding sites [ion binding]; other site
1028799005161	acetyl-CoA synthetase; Provisional; Region: PRK04319
1028799005162	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1028799005163	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1028799005164	active site
1028799005165	acyl-activating enzyme (AAE) consensus motif; other site
1028799005166	putative CoA binding site [chemical binding]; other site
1028799005167	AMP binding site [chemical binding]; other site
1028799005168	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1028799005169	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1028799005170	active site
1028799005171	Zn binding site [ion binding]; other site
1028799005172	catabolite control protein A; Region: ccpA; TIGR01481
1028799005173	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1028799005174	DNA binding site [nucleotide binding]
1028799005175	domain linker motif; other site
1028799005176	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1028799005177	dimerization interface [polypeptide binding]; other site
1028799005178	effector binding site; other site
1028799005179	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1028799005180	Chorismate mutase type II; Region: CM_2; cl00693
1028799005181	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1028799005182	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1028799005183	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1028799005184	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1028799005185	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1028799005186	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1028799005187	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1028799005188	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1028799005189	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1028799005190	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1028799005191	putative tRNA-binding site [nucleotide binding]; other site
1028799005192	hypothetical protein; Provisional; Region: PRK13668
1028799005193	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1028799005194	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1028799005195	catalytic residues [active]
1028799005196	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1028799005197	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1028799005198	oligomer interface [polypeptide binding]; other site
1028799005199	active site
1028799005200	metal binding site [ion binding]; metal-binding site
1028799005201	Predicted small secreted protein [Function unknown]; Region: COG5584
1028799005202	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1028799005203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799005204	S-adenosylmethionine binding site [chemical binding]; other site
1028799005205	Phosphotransferase enzyme family; Region: APH; pfam01636
1028799005206	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1028799005207	substrate binding site [chemical binding]; other site
1028799005208	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1028799005209	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1028799005210	homodimer interface [polypeptide binding]; other site
1028799005211	substrate-cofactor binding pocket; other site
1028799005212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799005213	catalytic residue [active]
1028799005214	dipeptidase PepV; Reviewed; Region: PRK07318
1028799005215	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1028799005216	active site
1028799005217	metal binding site [ion binding]; metal-binding site
1028799005218	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1028799005219	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1028799005220	RNA binding surface [nucleotide binding]; other site
1028799005221	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1028799005222	active site
1028799005223	uracil binding [chemical binding]; other site
1028799005224	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1028799005225	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1028799005226	HI0933-like protein; Region: HI0933_like; pfam03486
1028799005227	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799005228	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1028799005229	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005230	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005231	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005232	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005233	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005234	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005235	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005236	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005237	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005238	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005239	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005240	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005241	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005242	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005243	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799005244	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1028799005245	active site residue [active]
1028799005246	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1028799005247	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1028799005248	HIGH motif; other site
1028799005249	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1028799005250	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1028799005251	active site
1028799005252	KMSKS motif; other site
1028799005253	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1028799005254	tRNA binding surface [nucleotide binding]; other site
1028799005255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799005256	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799005257	putative substrate translocation pore; other site
1028799005258	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1028799005259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799005260	S-adenosylmethionine binding site [chemical binding]; other site
1028799005261	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799005262	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1028799005263	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1028799005264	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1028799005265	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1028799005266	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1028799005267	homopentamer interface [polypeptide binding]; other site
1028799005268	active site
1028799005269	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1028799005270	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1028799005271	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1028799005272	dimerization interface [polypeptide binding]; other site
1028799005273	active site
1028799005274	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1028799005275	Lumazine binding domain; Region: Lum_binding; pfam00677
1028799005276	Lumazine binding domain; Region: Lum_binding; pfam00677
1028799005277	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1028799005278	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1028799005279	catalytic motif [active]
1028799005280	Zn binding site [ion binding]; other site
1028799005281	RibD C-terminal domain; Region: RibD_C; cl17279
1028799005282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1028799005283	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1028799005284	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1028799005285	dimerization interface [polypeptide binding]; other site
1028799005286	putative DNA binding site [nucleotide binding]; other site
1028799005287	putative Zn2+ binding site [ion binding]; other site
1028799005288	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1028799005289	arsenical pump membrane protein; Provisional; Region: PRK15445
1028799005290	transmembrane helices; other site
1028799005291	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1028799005292	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1028799005293	active site
1028799005294	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1028799005295	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1028799005296	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1028799005297	DNA binding residues [nucleotide binding]
1028799005298	CAAX protease self-immunity; Region: Abi; pfam02517
1028799005299	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1028799005300	active site
1028799005301	intersubunit interactions; other site
1028799005302	catalytic residue [active]
1028799005303	camphor resistance protein CrcB; Provisional; Region: PRK14201
1028799005304	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1028799005305	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1028799005306	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1028799005307	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1028799005308	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1028799005309	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1028799005310	active site
1028799005311	catalytic tetrad [active]
1028799005312	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1028799005313	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1028799005314	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1028799005315	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1028799005316	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1028799005317	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1028799005318	active site
1028799005319	substrate-binding site [chemical binding]; other site
1028799005320	metal-binding site [ion binding]
1028799005321	ATP binding site [chemical binding]; other site
1028799005322	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1028799005323	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1028799005324	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1028799005325	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
1028799005326	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
1028799005327	nudix motif; other site
1028799005328	Haemolytic domain; Region: Haemolytic; pfam01809
1028799005329	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1028799005330	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1028799005331	metal binding site [ion binding]; metal-binding site
1028799005332	substrate binding pocket [chemical binding]; other site
1028799005333	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1028799005334	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
1028799005335	acyl-activating enzyme (AAE) consensus motif; other site
1028799005336	putative AMP binding site [chemical binding]; other site
1028799005337	putative active site [active]
1028799005338	putative CoA binding site [chemical binding]; other site
1028799005339	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1028799005340	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1028799005341	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
1028799005342	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1028799005343	putative transposase OrfB; Reviewed; Region: PHA02517
1028799005344	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1028799005345	Transposase; Region: HTH_Tnp_1; cl17663
1028799005346	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1028799005347	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1028799005348	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1028799005349	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1028799005350	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1028799005351	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1028799005352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799005353	S-adenosylmethionine binding site [chemical binding]; other site
1028799005354	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1028799005355	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1028799005356	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1028799005357	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1028799005358	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1028799005359	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1028799005360	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1028799005361	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1028799005362	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1028799005363	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1028799005364	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
1028799005365	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1028799005366	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1028799005367	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799005368	Walker A/P-loop; other site
1028799005369	ATP binding site [chemical binding]; other site
1028799005370	Q-loop/lid; other site
1028799005371	ABC transporter signature motif; other site
1028799005372	Walker B; other site
1028799005373	D-loop; other site
1028799005374	H-loop/switch region; other site
1028799005375	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
1028799005376	active site
1028799005377	catalytic triad [active]
1028799005378	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
1028799005379	Flavoprotein; Region: Flavoprotein; pfam02441
1028799005380	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
1028799005381	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
1028799005382	active site
1028799005383	zinc binding site [ion binding]; other site
1028799005384	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
1028799005385	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
1028799005386	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
1028799005387	lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731
1028799005388	lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731
1028799005389	beta-channel forming cytolysin; Region: hlyII; TIGR01002
1028799005390	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1028799005391	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1028799005392	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1028799005393	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1028799005394	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1028799005395	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1028799005396	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1028799005397	ferrochelatase; Provisional; Region: PRK12435
1028799005398	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1028799005399	C-terminal domain interface [polypeptide binding]; other site
1028799005400	active site
1028799005401	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1028799005402	active site
1028799005403	N-terminal domain interface [polypeptide binding]; other site
1028799005404	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1028799005405	substrate binding site [chemical binding]; other site
1028799005406	active site
1028799005407	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1028799005408	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1028799005409	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1028799005410	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1028799005411	Walker A/P-loop; other site
1028799005412	ATP binding site [chemical binding]; other site
1028799005413	Q-loop/lid; other site
1028799005414	ABC transporter signature motif; other site
1028799005415	Walker B; other site
1028799005416	D-loop; other site
1028799005417	H-loop/switch region; other site
1028799005418	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1028799005419	HIT family signature motif; other site
1028799005420	catalytic residue [active]
1028799005421	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
1028799005422	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1028799005423	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1028799005424	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1028799005425	generic binding surface II; other site
1028799005426	generic binding surface I; other site
1028799005427	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1028799005428	Zn2+ binding site [ion binding]; other site
1028799005429	Mg2+ binding site [ion binding]; other site
1028799005430	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1028799005431	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1028799005432	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
1028799005433	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1028799005434	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1028799005435	active site
1028799005436	metal binding site [ion binding]; metal-binding site
1028799005437	DNA binding site [nucleotide binding]
1028799005438	hypothetical protein; Provisional; Region: PRK13676
1028799005439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1028799005440	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1028799005441	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1028799005442	non-specific DNA binding site [nucleotide binding]; other site
1028799005443	salt bridge; other site
1028799005444	sequence-specific DNA binding site [nucleotide binding]; other site
1028799005445	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1028799005446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799005447	active site
1028799005448	phosphorylation site [posttranslational modification]
1028799005449	intermolecular recognition site; other site
1028799005450	dimerization interface [polypeptide binding]; other site
1028799005451	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1028799005452	DNA binding residues [nucleotide binding]
1028799005453	dimerization interface [polypeptide binding]; other site
1028799005454	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1028799005455	GAF domain; Region: GAF_3; pfam13492
1028799005456	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1028799005457	Histidine kinase; Region: HisKA_3; pfam07730
1028799005458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799005459	ATP binding site [chemical binding]; other site
1028799005460	Mg2+ binding site [ion binding]; other site
1028799005461	G-X-G motif; other site
1028799005462	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1028799005463	active site
1028799005464	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1028799005465	Class II fumarases; Region: Fumarase_classII; cd01362
1028799005466	active site
1028799005467	tetramer interface [polypeptide binding]; other site
1028799005468	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
1028799005469	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1028799005470	active site
1028799005471	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1028799005472	epoxyqueuosine reductase; Region: TIGR00276
1028799005473	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1028799005474	HEAT repeats; Region: HEAT_2; pfam13646
1028799005475	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1028799005476	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1028799005477	Walker A/P-loop; other site
1028799005478	ATP binding site [chemical binding]; other site
1028799005479	Q-loop/lid; other site
1028799005480	ABC transporter signature motif; other site
1028799005481	Walker B; other site
1028799005482	D-loop; other site
1028799005483	H-loop/switch region; other site
1028799005484	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1028799005485	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1028799005486	substrate binding pocket [chemical binding]; other site
1028799005487	membrane-bound complex binding site; other site
1028799005488	hinge residues; other site
1028799005489	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1028799005490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799005491	dimer interface [polypeptide binding]; other site
1028799005492	conserved gate region; other site
1028799005493	putative PBP binding loops; other site
1028799005494	ABC-ATPase subunit interface; other site
1028799005495	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1028799005496	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1028799005497	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1028799005498	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1028799005499	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1028799005500	metal binding site 2 [ion binding]; metal-binding site
1028799005501	putative DNA binding helix; other site
1028799005502	metal binding site 1 [ion binding]; metal-binding site
1028799005503	dimer interface [polypeptide binding]; other site
1028799005504	structural Zn2+ binding site [ion binding]; other site
1028799005505	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
1028799005506	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1028799005507	putative ligand binding site [chemical binding]; other site
1028799005508	NAD binding site [chemical binding]; other site
1028799005509	catalytic site [active]
1028799005510	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1028799005511	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1028799005512	catalytic triad [active]
1028799005513	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1028799005514	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1028799005515	inhibitor-cofactor binding pocket; inhibition site
1028799005516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799005517	catalytic residue [active]
1028799005518	Predicted membrane protein [Function unknown]; Region: COG4129
1028799005519	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1028799005520	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1028799005521	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1028799005522	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1028799005523	Walker A/P-loop; other site
1028799005524	ATP binding site [chemical binding]; other site
1028799005525	Q-loop/lid; other site
1028799005526	ABC transporter signature motif; other site
1028799005527	Walker B; other site
1028799005528	D-loop; other site
1028799005529	H-loop/switch region; other site
1028799005530	hypothetical protein; Provisional; Region: PRK13662
1028799005531	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1028799005532	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1028799005533	minor groove reading motif; other site
1028799005534	helix-hairpin-helix signature motif; other site
1028799005535	substrate binding pocket [chemical binding]; other site
1028799005536	active site
1028799005537	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1028799005538	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1028799005539	DNA binding and oxoG recognition site [nucleotide binding]
1028799005540	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1028799005541	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1028799005542	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799005543	Walker A/P-loop; other site
1028799005544	ATP binding site [chemical binding]; other site
1028799005545	Q-loop/lid; other site
1028799005546	ABC transporter signature motif; other site
1028799005547	Walker B; other site
1028799005548	H-loop/switch region; other site
1028799005549	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1028799005550	recombination regulator RecX; Provisional; Region: recX; PRK14135
1028799005551	glycosyltransferase; Provisional; Region: PRK13481
1028799005552	Transglycosylase; Region: Transgly; pfam00912
1028799005553	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1028799005554	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1028799005555	proposed catalytic triad [active]
1028799005556	conserved cys residue [active]
1028799005557	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1028799005558	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799005559	FeS/SAM binding site; other site
1028799005560	YfkB-like domain; Region: YfkB; pfam08756
1028799005561	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1028799005562	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1028799005563	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1028799005564	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
1028799005565	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1028799005566	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1028799005567	active site
1028799005568	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1028799005569	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1028799005570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799005571	active site
1028799005572	phosphorylation site [posttranslational modification]
1028799005573	intermolecular recognition site; other site
1028799005574	dimerization interface [polypeptide binding]; other site
1028799005575	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1028799005576	DNA binding residues [nucleotide binding]
1028799005577	dimerization interface [polypeptide binding]; other site
1028799005578	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1028799005579	Histidine kinase; Region: HisKA_3; pfam07730
1028799005580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799005581	ATP binding site [chemical binding]; other site
1028799005582	Mg2+ binding site [ion binding]; other site
1028799005583	G-X-G motif; other site
1028799005584	Predicted membrane protein [Function unknown]; Region: COG4758
1028799005585	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1028799005586	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1028799005587	active site
1028799005588	Predicted membrane protein [Function unknown]; Region: COG4129
1028799005589	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1028799005590	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799005591	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1028799005592	catalytic triad [active]
1028799005593	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1028799005594	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1028799005595	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1028799005596	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1028799005597	Ferritin-like domain; Region: Ferritin; pfam00210
1028799005598	ferroxidase diiron center [ion binding]; other site
1028799005599	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1028799005600	active site
1028799005601	catalytic site [active]
1028799005602	substrate binding site [chemical binding]; other site
1028799005603	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1028799005604	active site
1028799005605	DNA polymerase IV; Validated; Region: PRK02406
1028799005606	DNA binding site [nucleotide binding]
1028799005607	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1028799005608	TRAM domain; Region: TRAM; cl01282
1028799005609	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1028799005610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799005611	S-adenosylmethionine binding site [chemical binding]; other site
1028799005612	putative lipid kinase; Reviewed; Region: PRK13337
1028799005613	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1028799005614	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
1028799005615	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1028799005616	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1028799005617	GatB domain; Region: GatB_Yqey; pfam02637
1028799005618	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1028799005619	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1028799005620	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1028799005621	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1028799005622	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1028799005623	Na binding site [ion binding]; other site
1028799005624	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
1028799005625	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1028799005626	putative dimer interface [polypeptide binding]; other site
1028799005627	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1028799005628	putative dimer interface [polypeptide binding]; other site
1028799005629	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1028799005630	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1028799005631	nucleotide binding pocket [chemical binding]; other site
1028799005632	K-X-D-G motif; other site
1028799005633	catalytic site [active]
1028799005634	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1028799005635	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1028799005636	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1028799005637	Dimer interface [polypeptide binding]; other site
1028799005638	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1028799005639	Part of AAA domain; Region: AAA_19; pfam13245
1028799005640	Family description; Region: UvrD_C_2; pfam13538
1028799005641	PcrB family; Region: PcrB; pfam01884
1028799005642	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1028799005643	substrate binding site [chemical binding]; other site
1028799005644	putative active site [active]
1028799005645	dimer interface [polypeptide binding]; other site
1028799005646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
1028799005647	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1028799005648	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1028799005649	tetramer interface [polypeptide binding]; other site
1028799005650	active site
1028799005651	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1028799005652	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1028799005653	Staphostatin A; Region: Staphostatin_A; pfam09022
1028799005654	NETI protein; Region: NETI; pfam14044
1028799005655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
1028799005656	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1028799005657	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1028799005658	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1028799005659	homodimer interface [polypeptide binding]; other site
1028799005660	NAD binding pocket [chemical binding]; other site
1028799005661	ATP binding pocket [chemical binding]; other site
1028799005662	Mg binding site [ion binding]; other site
1028799005663	active-site loop [active]
1028799005664	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1028799005665	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1028799005666	active site
1028799005667	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
1028799005668	active site
1028799005669	dimer interface [polypeptide binding]; other site
1028799005670	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1028799005671	Prephenate dehydratase; Region: PDT; pfam00800
1028799005672	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1028799005673	putative L-Phe binding site [chemical binding]; other site
1028799005674	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1028799005675	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1028799005676	transmembrane helices; other site
1028799005677	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1028799005678	Isochorismatase family; Region: Isochorismatase; pfam00857
1028799005679	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1028799005680	catalytic triad [active]
1028799005681	conserved cis-peptide bond; other site
1028799005682	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1028799005683	DHH family; Region: DHH; pfam01368
1028799005684	DHHA2 domain; Region: DHHA2; pfam02833
1028799005685	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1028799005686	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1028799005687	NAD(P) binding site [chemical binding]; other site
1028799005688	catalytic residues [active]
1028799005689	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
1028799005690	YolD-like protein; Region: YolD; pfam08863
1028799005691	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
1028799005692	active site
1028799005693	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
1028799005694	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1028799005695	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1028799005696	Bacterial PH domain; Region: DUF304; cl01348
1028799005697	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
1028799005698	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1028799005699	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1028799005700	Walker A/P-loop; other site
1028799005701	ATP binding site [chemical binding]; other site
1028799005702	Q-loop/lid; other site
1028799005703	ABC transporter signature motif; other site
1028799005704	Walker B; other site
1028799005705	D-loop; other site
1028799005706	H-loop/switch region; other site
1028799005707	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1028799005708	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1028799005709	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1028799005710	Walker A/P-loop; other site
1028799005711	ATP binding site [chemical binding]; other site
1028799005712	Q-loop/lid; other site
1028799005713	ABC transporter signature motif; other site
1028799005714	Walker B; other site
1028799005715	D-loop; other site
1028799005716	H-loop/switch region; other site
1028799005717	Predicted transcriptional regulators [Transcription]; Region: COG1725
1028799005718	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1028799005719	DNA-binding site [nucleotide binding]; DNA binding site
1028799005720	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1028799005721	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1028799005722	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799005723	homodimer interface [polypeptide binding]; other site
1028799005724	catalytic residue [active]
1028799005725	MAP domain; Region: MAP; pfam03642
1028799005726	MAP domain; Region: MAP; pfam03642
1028799005727	MAP domain; Region: MAP; pfam03642
1028799005728	MAP domain; Region: MAP; pfam03642
1028799005729	MAP domain; Region: MAP; pfam03642
1028799005730	MAP domain; Region: MAP; pfam03642
1028799005731	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
1028799005732	putative catalytic site [active]
1028799005733	phosphate binding site [ion binding]; other site
1028799005734	metal binding site A [ion binding]; metal-binding site
1028799005735	metal binding site C [ion binding]; metal-binding site
1028799005736	metal binding site B [ion binding]; metal-binding site
1028799005737	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1028799005738	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1028799005739	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1028799005740	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1028799005741	metal binding site [ion binding]; metal-binding site
1028799005742	dimer interface [polypeptide binding]; other site
1028799005743	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1028799005744	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1028799005745	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1028799005746	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1028799005747	putative ligand binding residues [chemical binding]; other site
1028799005748	Cation transport protein; Region: TrkH; cl17365
1028799005749	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1028799005750	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799005751	Coenzyme A binding pocket [chemical binding]; other site
1028799005752	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
1028799005753	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1028799005754	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1028799005755	Int/Topo IB signature motif; other site
1028799005756	DNA binding site [nucleotide binding]
1028799005757	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1028799005758	DNA binding site [nucleotide binding]
1028799005759	active site
1028799005760	Int/Topo IB signature motif; other site
1028799005761	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1028799005762	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1028799005763	ring oligomerisation interface [polypeptide binding]; other site
1028799005764	ATP/Mg binding site [chemical binding]; other site
1028799005765	stacking interactions; other site
1028799005766	hinge regions; other site
1028799005767	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1028799005768	oligomerisation interface [polypeptide binding]; other site
1028799005769	mobile loop; other site
1028799005770	roof hairpin; other site
1028799005771	CAAX protease self-immunity; Region: Abi; pfam02517
1028799005772	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1028799005773	dimer interface [polypeptide binding]; other site
1028799005774	FMN binding site [chemical binding]; other site
1028799005775	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1028799005776	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1028799005777	putative active site [active]
1028799005778	catalytic triad [active]
1028799005779	putative dimer interface [polypeptide binding]; other site
1028799005780	delta-hemolysin; Provisional; Region: PRK14752
1028799005781	Accessory gene regulator B; Region: AgrB; smart00793
1028799005782	Staphylococcal AgrD protein; Region: AgrD; smart00794
1028799005783	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1028799005784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799005785	Mg2+ binding site [ion binding]; other site
1028799005786	G-X-G motif; other site
1028799005787	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1028799005788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799005789	active site
1028799005790	phosphorylation site [posttranslational modification]
1028799005791	intermolecular recognition site; other site
1028799005792	dimerization interface [polypeptide binding]; other site
1028799005793	LytTr DNA-binding domain; Region: LytTR; pfam04397
1028799005794	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1028799005795	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1028799005796	putative substrate binding site [chemical binding]; other site
1028799005797	putative ATP binding site [chemical binding]; other site
1028799005798	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1028799005799	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1028799005800	substrate binding [chemical binding]; other site
1028799005801	active site
1028799005802	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1028799005803	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1028799005804	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1028799005805	DNA binding site [nucleotide binding]
1028799005806	domain linker motif; other site
1028799005807	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1028799005808	dimerization interface [polypeptide binding]; other site
1028799005809	ligand binding site [chemical binding]; other site
1028799005810	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1028799005811	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1028799005812	CPxP  motif; other site
1028799005813	Predicted transporter component [General function prediction only]; Region: COG2391
1028799005814	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
1028799005815	Sulphur transport; Region: Sulf_transp; pfam04143
1028799005816	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
1028799005817	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1028799005818	CoA binding domain; Region: CoA_binding; pfam02629
1028799005819	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1028799005820	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1028799005821	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1028799005822	ABC transporter; Region: ABC_tran_2; pfam12848
1028799005823	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1028799005824	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
1028799005825	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
1028799005826	Walker A/P-loop; other site
1028799005827	ATP binding site [chemical binding]; other site
1028799005828	Q-loop/lid; other site
1028799005829	ABC transporter signature motif; other site
1028799005830	Walker B; other site
1028799005831	D-loop; other site
1028799005832	H-loop/switch region; other site
1028799005833	UGMP family protein; Validated; Region: PRK09604
1028799005834	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1028799005835	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1028799005836	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799005837	Coenzyme A binding pocket [chemical binding]; other site
1028799005838	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1028799005839	Glycoprotease family; Region: Peptidase_M22; pfam00814
1028799005840	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1028799005841	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1028799005842	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1028799005843	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
1028799005844	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1028799005845	PYR/PP interface [polypeptide binding]; other site
1028799005846	dimer interface [polypeptide binding]; other site
1028799005847	TPP binding site [chemical binding]; other site
1028799005848	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1028799005849	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1028799005850	TPP-binding site [chemical binding]; other site
1028799005851	dimer interface [polypeptide binding]; other site
1028799005852	acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562
1028799005853	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
1028799005854	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1028799005855	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1028799005856	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1028799005857	2-isopropylmalate synthase; Validated; Region: PRK00915
1028799005858	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1028799005859	active site
1028799005860	catalytic residues [active]
1028799005861	metal binding site [ion binding]; metal-binding site
1028799005862	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1028799005863	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1028799005864	tartrate dehydrogenase; Region: TTC; TIGR02089
1028799005865	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1028799005866	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1028799005867	substrate binding site [chemical binding]; other site
1028799005868	ligand binding site [chemical binding]; other site
1028799005869	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1028799005870	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1028799005871	substrate binding site [chemical binding]; other site
1028799005872	threonine dehydratase; Validated; Region: PRK08639
1028799005873	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1028799005874	tetramer interface [polypeptide binding]; other site
1028799005875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799005876	catalytic residue [active]
1028799005877	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1028799005878	putative Ile/Val binding site [chemical binding]; other site
1028799005879	hypothetical protein; Provisional; Region: PRK04351
1028799005880	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1028799005881	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1028799005882	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1028799005883	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1028799005884	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1028799005885	RNA binding site [nucleotide binding]; other site
1028799005886	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
1028799005887	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1028799005888	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1028799005889	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1028799005890	DNA binding residues [nucleotide binding]
1028799005891	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1028799005892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799005893	ATP binding site [chemical binding]; other site
1028799005894	Mg2+ binding site [ion binding]; other site
1028799005895	G-X-G motif; other site
1028799005896	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1028799005897	anti sigma factor interaction site; other site
1028799005898	regulatory phosphorylation site [posttranslational modification]; other site
1028799005899	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1028799005900	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1028799005901	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
1028799005902	PemK-like protein; Region: PemK; pfam02452
1028799005903	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1028799005904	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1028799005905	active site
1028799005906	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1028799005907	dimer interface [polypeptide binding]; other site
1028799005908	substrate binding site [chemical binding]; other site
1028799005909	catalytic residues [active]
1028799005910	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1028799005911	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1028799005912	Predicted membrane protein [Function unknown]; Region: COG3428
1028799005913	Bacterial PH domain; Region: DUF304; pfam03703
1028799005914	Bacterial PH domain; Region: DUF304; pfam03703
1028799005915	Bacterial PH domain; Region: DUF304; cl01348
1028799005916	potassium-transporting ATPase subunit C; Provisional; Region: PRK13998
1028799005917	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
1028799005918	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1028799005919	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1028799005920	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
1028799005921	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1028799005922	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1028799005923	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1028799005924	Ligand Binding Site [chemical binding]; other site
1028799005925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1028799005926	dimer interface [polypeptide binding]; other site
1028799005927	phosphorylation site [posttranslational modification]
1028799005928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799005929	ATP binding site [chemical binding]; other site
1028799005930	Mg2+ binding site [ion binding]; other site
1028799005931	G-X-G motif; other site
1028799005932	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1028799005933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799005934	active site
1028799005935	phosphorylation site [posttranslational modification]
1028799005936	intermolecular recognition site; other site
1028799005937	dimerization interface [polypeptide binding]; other site
1028799005938	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1028799005939	DNA binding site [nucleotide binding]
1028799005940	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1028799005941	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1028799005942	ATP binding site [chemical binding]; other site
1028799005943	Mg++ binding site [ion binding]; other site
1028799005944	motif III; other site
1028799005945	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1028799005946	nucleotide binding region [chemical binding]; other site
1028799005947	ATP-binding site [chemical binding]; other site
1028799005948	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1028799005949	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1028799005950	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1028799005951	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1028799005952	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1028799005953	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1028799005954	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1028799005955	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1028799005956	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1028799005957	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
1028799005958	putative homodimer interface [polypeptide binding]; other site
1028799005959	putative homotetramer interface [polypeptide binding]; other site
1028799005960	allosteric switch controlling residues; other site
1028799005961	putative metal binding site [ion binding]; other site
1028799005962	putative homodimer-homodimer interface [polypeptide binding]; other site
1028799005963	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1028799005964	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1028799005965	putative active site [active]
1028799005966	catalytic site [active]
1028799005967	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1028799005968	putative active site [active]
1028799005969	catalytic site [active]
1028799005970	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1028799005971	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1028799005972	Zn2+ binding site [ion binding]; other site
1028799005973	Mg2+ binding site [ion binding]; other site
1028799005974	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1028799005975	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1028799005976	thiamine phosphate binding site [chemical binding]; other site
1028799005977	active site
1028799005978	pyrophosphate binding site [ion binding]; other site
1028799005979	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1028799005980	substrate binding site [chemical binding]; other site
1028799005981	multimerization interface [polypeptide binding]; other site
1028799005982	ATP binding site [chemical binding]; other site
1028799005983	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1028799005984	dimer interface [polypeptide binding]; other site
1028799005985	substrate binding site [chemical binding]; other site
1028799005986	ATP binding site [chemical binding]; other site
1028799005987	thiaminase II; Region: salvage_TenA; TIGR04306
1028799005988	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1028799005989	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1028799005990	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1028799005991	dimer interface [polypeptide binding]; other site
1028799005992	ssDNA binding site [nucleotide binding]; other site
1028799005993	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1028799005994	YwpF-like protein; Region: YwpF; pfam14183
1028799005995	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1028799005996	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1028799005997	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1028799005998	hinge; other site
1028799005999	active site
1028799006000	Predicted membrane protein [Function unknown]; Region: COG4836
1028799006001	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
1028799006002	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1028799006003	gamma subunit interface [polypeptide binding]; other site
1028799006004	epsilon subunit interface [polypeptide binding]; other site
1028799006005	LBP interface [polypeptide binding]; other site
1028799006006	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1028799006007	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1028799006008	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1028799006009	alpha subunit interaction interface [polypeptide binding]; other site
1028799006010	Walker A motif; other site
1028799006011	ATP binding site [chemical binding]; other site
1028799006012	Walker B motif; other site
1028799006013	inhibitor binding site; inhibition site
1028799006014	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1028799006015	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1028799006016	core domain interface [polypeptide binding]; other site
1028799006017	delta subunit interface [polypeptide binding]; other site
1028799006018	epsilon subunit interface [polypeptide binding]; other site
1028799006019	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1028799006020	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1028799006021	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1028799006022	beta subunit interaction interface [polypeptide binding]; other site
1028799006023	Walker A motif; other site
1028799006024	ATP binding site [chemical binding]; other site
1028799006025	Walker B motif; other site
1028799006026	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1028799006027	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1028799006028	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1028799006029	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
1028799006030	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1028799006031	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1028799006032	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1028799006033	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1028799006034	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1028799006035	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1028799006036	active site
1028799006037	homodimer interface [polypeptide binding]; other site
1028799006038	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1028799006039	active site
1028799006040	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1028799006041	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1028799006042	dimer interface [polypeptide binding]; other site
1028799006043	active site
1028799006044	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1028799006045	folate binding site [chemical binding]; other site
1028799006046	hypothetical protein; Provisional; Region: PRK13690
1028799006047	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1028799006048	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1028799006049	active site
1028799006050	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1028799006051	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1028799006052	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1028799006053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799006054	S-adenosylmethionine binding site [chemical binding]; other site
1028799006055	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1028799006056	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1028799006057	RF-1 domain; Region: RF-1; pfam00472
1028799006058	thymidine kinase; Provisional; Region: PRK04296
1028799006059	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1028799006060	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1028799006061	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1028799006062	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1028799006063	RNA binding site [nucleotide binding]; other site
1028799006064	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1028799006065	multimer interface [polypeptide binding]; other site
1028799006066	Walker A motif; other site
1028799006067	ATP binding site [chemical binding]; other site
1028799006068	Walker B motif; other site
1028799006069	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1028799006070	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1028799006071	NAD binding site [chemical binding]; other site
1028799006072	catalytic residues [active]
1028799006073	Predicted transcriptional regulators [Transcription]; Region: COG1733
1028799006074	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1028799006075	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1028799006076	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1028799006077	hinge; other site
1028799006078	active site
1028799006079	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1028799006080	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1028799006081	intersubunit interface [polypeptide binding]; other site
1028799006082	active site
1028799006083	zinc binding site [ion binding]; other site
1028799006084	Na+ binding site [ion binding]; other site
1028799006085	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1028799006086	CTP synthetase; Validated; Region: pyrG; PRK05380
1028799006087	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1028799006088	Catalytic site [active]
1028799006089	active site
1028799006090	UTP binding site [chemical binding]; other site
1028799006091	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1028799006092	active site
1028799006093	putative oxyanion hole; other site
1028799006094	catalytic triad [active]
1028799006095	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1028799006096	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1028799006097	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799006098	Coenzyme A binding pocket [chemical binding]; other site
1028799006099	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1028799006100	Coenzyme A binding pocket [chemical binding]; other site
1028799006101	pantothenate kinase; Provisional; Region: PRK13317
1028799006102	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
1028799006103	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1028799006104	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1028799006105	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1028799006106	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1028799006107	metal binding site [ion binding]; metal-binding site
1028799006108	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1028799006109	Predicted membrane protein [Function unknown]; Region: COG4270
1028799006110	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1028799006111	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1028799006112	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1028799006113	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1028799006114	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1028799006115	intersubunit interface [polypeptide binding]; other site
1028799006116	active site
1028799006117	catalytic residue [active]
1028799006118	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1028799006119	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1028799006120	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1028799006121	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1028799006122	dimerization interface [polypeptide binding]; other site
1028799006123	DPS ferroxidase diiron center [ion binding]; other site
1028799006124	ion pore; other site
1028799006125	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1028799006126	EVE domain; Region: EVE; cl00728
1028799006127	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1028799006128	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1028799006129	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1028799006130	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1028799006131	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1028799006132	NAD(P) binding site [chemical binding]; other site
1028799006133	putative active site [active]
1028799006134	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1028799006135	dimerization interface [polypeptide binding]; other site
1028799006136	putative DNA binding site [nucleotide binding]; other site
1028799006137	putative Zn2+ binding site [ion binding]; other site
1028799006138	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1028799006139	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1028799006140	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1028799006141	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1028799006142	catalytic residues [active]
1028799006143	SAP domain; Region: SAP; pfam02037
1028799006144	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1028799006145	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799006146	active site
1028799006147	motif I; other site
1028799006148	motif II; other site
1028799006149	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799006150	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1028799006151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799006152	Walker A/P-loop; other site
1028799006153	ATP binding site [chemical binding]; other site
1028799006154	Q-loop/lid; other site
1028799006155	ABC transporter signature motif; other site
1028799006156	Walker B; other site
1028799006157	D-loop; other site
1028799006158	H-loop/switch region; other site
1028799006159	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1028799006160	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1028799006161	glutaminase active site [active]
1028799006162	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1028799006163	dimer interface [polypeptide binding]; other site
1028799006164	active site
1028799006165	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1028799006166	dimer interface [polypeptide binding]; other site
1028799006167	active site
1028799006168	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1028799006169	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1028799006170	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1028799006171	active site
1028799006172	P-loop; other site
1028799006173	phosphorylation site [posttranslational modification]
1028799006174	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1028799006175	HTH domain; Region: HTH_11; pfam08279
1028799006176	Mga helix-turn-helix domain; Region: Mga; pfam05043
1028799006177	PRD domain; Region: PRD; pfam00874
1028799006178	PRD domain; Region: PRD; pfam00874
1028799006179	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1028799006180	active site
1028799006181	P-loop; other site
1028799006182	phosphorylation site [posttranslational modification]
1028799006183	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1028799006184	active site
1028799006185	phosphorylation site [posttranslational modification]
1028799006186	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1028799006187	active site
1028799006188	phosphorylation site [posttranslational modification]
1028799006189	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1028799006190	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1028799006191	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1028799006192	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799006193	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1028799006194	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799006195	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799006196	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799006197	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799006198	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799006199	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799006200	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1028799006201	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1028799006202	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1028799006203	active site
1028799006204	substrate binding site [chemical binding]; other site
1028799006205	metal binding site [ion binding]; metal-binding site
1028799006206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1028799006207	YbbR-like protein; Region: YbbR; pfam07949
1028799006208	TIGR00159 family protein; Region: TIGR00159
1028799006209	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1028799006210	Arginase family; Region: Arginase; cd09989
1028799006211	active site
1028799006212	Mn binding site [ion binding]; other site
1028799006213	oligomer interface [polypeptide binding]; other site
1028799006214	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1028799006215	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1028799006216	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1028799006217	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1028799006218	Walker A motif; other site
1028799006219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006220	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799006221	putative substrate translocation pore; other site
1028799006222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006223	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799006224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006225	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1028799006226	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1028799006227	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
1028799006228	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
1028799006229	substrate binding site; other site
1028799006230	dimerization interface; other site
1028799006231	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1028799006232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1028799006233	Nucleoside recognition; Region: Gate; pfam07670
1028799006234	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1028799006235	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799006236	ABC-ATPase subunit  interface; other site
1028799006237	dimer interface [polypeptide binding]; other site
1028799006238	putative PBP binding regions; other site
1028799006239	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1028799006240	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1028799006241	ABC-ATPase subunit  interface; other site
1028799006242	dimer interface [polypeptide binding]; other site
1028799006243	putative PBP binding regions; other site
1028799006244	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1028799006245	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1028799006246	siderophore binding site; other site
1028799006247	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
1028799006248	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
1028799006249	dimer interface [polypeptide binding]; other site
1028799006250	active site
1028799006251	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1028799006252	substrate binding site [chemical binding]; other site
1028799006253	catalytic residue [active]
1028799006254	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1028799006255	IucA / IucC family; Region: IucA_IucC; pfam04183
1028799006256	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1028799006257	H+ Antiporter protein; Region: 2A0121; TIGR00900
1028799006258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006259	putative substrate translocation pore; other site
1028799006260	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1028799006261	IucA / IucC family; Region: IucA_IucC; pfam04183
1028799006262	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1028799006263	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1028799006264	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1028799006265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1028799006266	Asp23 family; Region: Asp23; pfam03780
1028799006267	Small integral membrane protein [Function unknown]; Region: COG5547
1028799006268	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1028799006269	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1028799006270	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1028799006271	putative NAD(P) binding site [chemical binding]; other site
1028799006272	dimer interface [polypeptide binding]; other site
1028799006273	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1028799006274	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1028799006275	NAD(P) binding site [chemical binding]; other site
1028799006276	substrate binding site [chemical binding]; other site
1028799006277	dimer interface [polypeptide binding]; other site
1028799006278	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
1028799006279	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1028799006280	beta-galactosidase; Region: BGL; TIGR03356
1028799006281	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
1028799006282	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1028799006283	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1028799006284	active site
1028799006285	P-loop; other site
1028799006286	phosphorylation site [posttranslational modification]
1028799006287	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1028799006288	methionine cluster; other site
1028799006289	active site
1028799006290	phosphorylation site [posttranslational modification]
1028799006291	metal binding site [ion binding]; metal-binding site
1028799006292	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1028799006293	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1028799006294	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1028799006295	putative substrate binding site [chemical binding]; other site
1028799006296	putative ATP binding site [chemical binding]; other site
1028799006297	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1028799006298	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
1028799006299	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1028799006300	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1028799006301	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1028799006302	NAD-dependent deacetylase; Provisional; Region: PRK00481
1028799006303	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
1028799006304	NAD+ binding site [chemical binding]; other site
1028799006305	substrate binding site [chemical binding]; other site
1028799006306	putative Zn binding site [ion binding]; other site
1028799006307	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
1028799006308	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1028799006309	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1028799006310	active site
1028799006311	catalytic tetrad [active]
1028799006312	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1028799006313	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1028799006314	DNA binding residues [nucleotide binding]
1028799006315	putative dimer interface [polypeptide binding]; other site
1028799006316	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1028799006317	substrate binding site [chemical binding]; other site
1028799006318	catalytic residues [active]
1028799006319	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1028799006320	Peptidase family M23; Region: Peptidase_M23; pfam01551
1028799006321	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1028799006322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1028799006323	active site
1028799006324	motif I; other site
1028799006325	motif II; other site
1028799006326	MAP domain; Region: MAP; pfam03642
1028799006327	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1028799006328	acetolactate synthase; Reviewed; Region: PRK08617
1028799006329	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1028799006330	PYR/PP interface [polypeptide binding]; other site
1028799006331	dimer interface [polypeptide binding]; other site
1028799006332	TPP binding site [chemical binding]; other site
1028799006333	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1028799006334	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1028799006335	TPP-binding site [chemical binding]; other site
1028799006336	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1028799006337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799006338	Walker A motif; other site
1028799006339	ATP binding site [chemical binding]; other site
1028799006340	Walker B motif; other site
1028799006341	arginine finger; other site
1028799006342	Predicted helicase [General function prediction only]; Region: COG4889
1028799006343	Predicted helicase [General function prediction only]; Region: COG4889
1028799006344	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1028799006345	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1028799006346	23S rRNA interface [nucleotide binding]; other site
1028799006347	L3 interface [polypeptide binding]; other site
1028799006348	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1028799006349	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1028799006350	dimerization interface 3.5A [polypeptide binding]; other site
1028799006351	active site
1028799006352	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1028799006353	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
1028799006354	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1028799006355	Walker A/P-loop; other site
1028799006356	ATP binding site [chemical binding]; other site
1028799006357	Q-loop/lid; other site
1028799006358	ABC transporter signature motif; other site
1028799006359	Walker B; other site
1028799006360	D-loop; other site
1028799006361	H-loop/switch region; other site
1028799006362	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
1028799006363	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1028799006364	Walker A/P-loop; other site
1028799006365	ATP binding site [chemical binding]; other site
1028799006366	Q-loop/lid; other site
1028799006367	ABC transporter signature motif; other site
1028799006368	Walker B; other site
1028799006369	D-loop; other site
1028799006370	H-loop/switch region; other site
1028799006371	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1028799006372	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1028799006373	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1028799006374	alphaNTD homodimer interface [polypeptide binding]; other site
1028799006375	alphaNTD - beta interaction site [polypeptide binding]; other site
1028799006376	alphaNTD - beta' interaction site [polypeptide binding]; other site
1028799006377	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1028799006378	30S ribosomal protein S11; Validated; Region: PRK05309
1028799006379	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1028799006380	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1028799006381	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1028799006382	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1028799006383	rRNA binding site [nucleotide binding]; other site
1028799006384	predicted 30S ribosome binding site; other site
1028799006385	adenylate kinase; Reviewed; Region: adk; PRK00279
1028799006386	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1028799006387	AMP-binding site [chemical binding]; other site
1028799006388	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1028799006389	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1028799006390	SecY translocase; Region: SecY; pfam00344
1028799006391	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1028799006392	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1028799006393	23S rRNA binding site [nucleotide binding]; other site
1028799006394	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
1028799006395	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1028799006396	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1028799006397	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1028799006398	5S rRNA interface [nucleotide binding]; other site
1028799006399	L27 interface [polypeptide binding]; other site
1028799006400	23S rRNA interface [nucleotide binding]; other site
1028799006401	L5 interface [polypeptide binding]; other site
1028799006402	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1028799006403	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1028799006404	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1028799006405	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1028799006406	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1028799006407	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1028799006408	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1028799006409	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1028799006410	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1028799006411	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1028799006412	RNA binding site [nucleotide binding]; other site
1028799006413	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1028799006414	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1028799006415	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1028799006416	23S rRNA interface [nucleotide binding]; other site
1028799006417	putative translocon interaction site; other site
1028799006418	signal recognition particle (SRP54) interaction site; other site
1028799006419	L23 interface [polypeptide binding]; other site
1028799006420	trigger factor interaction site; other site
1028799006421	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1028799006422	23S rRNA interface [nucleotide binding]; other site
1028799006423	5S rRNA interface [nucleotide binding]; other site
1028799006424	putative antibiotic binding site [chemical binding]; other site
1028799006425	L25 interface [polypeptide binding]; other site
1028799006426	L27 interface [polypeptide binding]; other site
1028799006427	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1028799006428	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1028799006429	G-X-X-G motif; other site
1028799006430	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1028799006431	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1028799006432	putative translocon binding site; other site
1028799006433	protein-rRNA interface [nucleotide binding]; other site
1028799006434	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1028799006435	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1028799006436	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1028799006437	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1028799006438	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1028799006439	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1028799006440	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1028799006441	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1028799006442	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1028799006443	DNA topoisomerase III; Provisional; Region: PRK07726
1028799006444	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1028799006445	active site
1028799006446	putative interdomain interaction site [polypeptide binding]; other site
1028799006447	putative metal-binding site [ion binding]; other site
1028799006448	putative nucleotide binding site [chemical binding]; other site
1028799006449	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1028799006450	domain I; other site
1028799006451	DNA binding groove [nucleotide binding]
1028799006452	phosphate binding site [ion binding]; other site
1028799006453	domain II; other site
1028799006454	domain III; other site
1028799006455	nucleotide binding site [chemical binding]; other site
1028799006456	catalytic site [active]
1028799006457	domain IV; other site
1028799006458	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1028799006459	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799006460	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1028799006461	Coenzyme A binding pocket [chemical binding]; other site
1028799006462	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1028799006463	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1028799006464	Predicted permeases [General function prediction only]; Region: COG0679
1028799006465	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1028799006466	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1028799006467	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1028799006468	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1028799006469	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1028799006470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006471	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799006472	putative substrate translocation pore; other site
1028799006473	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799006474	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1028799006475	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1028799006476	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799006477	FeS/SAM binding site; other site
1028799006478	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1028799006479	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1028799006480	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1028799006481	GTP binding site; other site
1028799006482	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1028799006483	MoaE interaction surface [polypeptide binding]; other site
1028799006484	MoeB interaction surface [polypeptide binding]; other site
1028799006485	thiocarboxylated glycine; other site
1028799006486	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1028799006487	MoaE homodimer interface [polypeptide binding]; other site
1028799006488	MoaD interaction [polypeptide binding]; other site
1028799006489	active site residues [active]
1028799006490	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
1028799006491	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1028799006492	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1028799006493	dimer interface [polypeptide binding]; other site
1028799006494	putative functional site; other site
1028799006495	putative MPT binding site; other site
1028799006496	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1028799006497	trimer interface [polypeptide binding]; other site
1028799006498	dimer interface [polypeptide binding]; other site
1028799006499	putative active site [active]
1028799006500	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1028799006501	MPT binding site; other site
1028799006502	trimer interface [polypeptide binding]; other site
1028799006503	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1028799006504	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1028799006505	ATP binding site [chemical binding]; other site
1028799006506	substrate interface [chemical binding]; other site
1028799006507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799006508	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1028799006509	Walker A/P-loop; other site
1028799006510	ATP binding site [chemical binding]; other site
1028799006511	Q-loop/lid; other site
1028799006512	ABC transporter signature motif; other site
1028799006513	Walker B; other site
1028799006514	D-loop; other site
1028799006515	H-loop/switch region; other site
1028799006516	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1028799006517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799006518	dimer interface [polypeptide binding]; other site
1028799006519	conserved gate region; other site
1028799006520	putative PBP binding loops; other site
1028799006521	ABC-ATPase subunit interface; other site
1028799006522	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1028799006523	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1028799006524	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1028799006525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799006526	Coenzyme A binding pocket [chemical binding]; other site
1028799006527	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1028799006528	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
1028799006529	active site
1028799006530	dimerization interface [polypeptide binding]; other site
1028799006531	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1028799006532	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1028799006533	intersubunit interface [polypeptide binding]; other site
1028799006534	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1028799006535	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1028799006536	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1028799006537	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
1028799006538	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1028799006539	alpha-gamma subunit interface [polypeptide binding]; other site
1028799006540	beta-gamma subunit interface [polypeptide binding]; other site
1028799006541	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1028799006542	gamma-beta subunit interface [polypeptide binding]; other site
1028799006543	alpha-beta subunit interface [polypeptide binding]; other site
1028799006544	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1028799006545	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1028799006546	subunit interactions [polypeptide binding]; other site
1028799006547	active site
1028799006548	flap region; other site
1028799006549	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1028799006550	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1028799006551	dimer interface [polypeptide binding]; other site
1028799006552	catalytic residues [active]
1028799006553	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1028799006554	UreF; Region: UreF; pfam01730
1028799006555	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1028799006556	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1028799006557	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799006558	MarR family; Region: MarR_2; cl17246
1028799006559	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799006560	Helix-turn-helix domain; Region: HTH_18; pfam12833
1028799006561	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1028799006562	Surface antigen [General function prediction only]; Region: COG3942
1028799006563	CHAP domain; Region: CHAP; pfam05257
1028799006564	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1028799006565	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1028799006566	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1028799006567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
1028799006568	Surface antigen [General function prediction only]; Region: COG3942
1028799006569	CHAP domain; Region: CHAP; pfam05257
1028799006570	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1028799006571	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1028799006572	putative ligand binding site [chemical binding]; other site
1028799006573	putative NAD binding site [chemical binding]; other site
1028799006574	catalytic site [active]
1028799006575	hypothetical protein; Provisional; Region: PRK06753
1028799006576	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1028799006577	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1028799006578	Lysozyme subfamily 2; Region: LYZ2; smart00047
1028799006579	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1028799006580	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1028799006581	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1028799006582	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1028799006583	4Fe-4S binding domain; Region: Fer4; pfam00037
1028799006584	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1028799006585	[4Fe-4S] binding site [ion binding]; other site
1028799006586	molybdopterin cofactor binding site; other site
1028799006587	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1028799006588	molybdopterin cofactor binding site; other site
1028799006589	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1028799006590	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1028799006591	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1028799006592	active site
1028799006593	Predicted transcriptional regulator [Transcription]; Region: COG2378
1028799006594	HTH domain; Region: HTH_11; pfam08279
1028799006595	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1028799006596	CAAX protease self-immunity; Region: Abi; pfam02517
1028799006597	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1028799006598	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1028799006599	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1028799006600	putative active site [active]
1028799006601	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1028799006602	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1028799006603	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799006604	active site
1028799006605	motif I; other site
1028799006606	motif II; other site
1028799006607	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1028799006608	Sodium Bile acid symporter family; Region: SBF; pfam01758
1028799006609	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1028799006610	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1028799006611	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1028799006612	active site turn [active]
1028799006613	phosphorylation site [posttranslational modification]
1028799006614	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1028799006615	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1028799006616	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1028799006617	putative active site [active]
1028799006618	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1028799006619	putative hydrophobic ligand binding site [chemical binding]; other site
1028799006620	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1028799006621	oxidoreductase; Provisional; Region: PRK07985
1028799006622	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1028799006623	NAD(P) binding site [chemical binding]; other site
1028799006624	active site
1028799006625	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1028799006626	amidohydrolase; Region: amidohydrolases; TIGR01891
1028799006627	metal binding site [ion binding]; metal-binding site
1028799006628	dimer interface [polypeptide binding]; other site
1028799006629	imidazolonepropionase; Validated; Region: PRK09356
1028799006630	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1028799006631	active site
1028799006632	urocanate hydratase; Provisional; Region: PRK05414
1028799006633	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1028799006634	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1028799006635	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1028799006636	dimerization interface [polypeptide binding]; other site
1028799006637	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1028799006638	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
1028799006639	putative active site [active]
1028799006640	putative Mg binding site [ion binding]; other site
1028799006641	formimidoylglutamase; Provisional; Region: PRK13775
1028799006642	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1028799006643	putative active site [active]
1028799006644	putative metal binding site [ion binding]; other site
1028799006645	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1028799006646	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1028799006647	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1028799006648	active site
1028799006649	dimer interface [polypeptide binding]; other site
1028799006650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1028799006651	MOSC domain; Region: MOSC; pfam03473
1028799006652	3-alpha domain; Region: 3-alpha; pfam03475
1028799006653	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1028799006654	active site
1028799006655	catalytic residues [active]
1028799006656	Uncharacterized conserved protein [Function unknown]; Region: COG1742
1028799006657	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1028799006658	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1028799006659	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799006660	Walker A/P-loop; other site
1028799006661	ATP binding site [chemical binding]; other site
1028799006662	Q-loop/lid; other site
1028799006663	ABC transporter signature motif; other site
1028799006664	Walker B; other site
1028799006665	D-loop; other site
1028799006666	H-loop/switch region; other site
1028799006667	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1028799006668	Predicted membrane protein [Function unknown]; Region: COG3152
1028799006669	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1028799006670	active site
1028799006671	DNA binding site [nucleotide binding]
1028799006672	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
1028799006673	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1028799006674	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1028799006675	homotetramer interface [polypeptide binding]; other site
1028799006676	FMN binding site [chemical binding]; other site
1028799006677	homodimer contacts [polypeptide binding]; other site
1028799006678	putative active site [active]
1028799006679	putative substrate binding site [chemical binding]; other site
1028799006680	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1028799006681	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1028799006682	oligomer interface [polypeptide binding]; other site
1028799006683	metal binding site [ion binding]; metal-binding site
1028799006684	metal binding site [ion binding]; metal-binding site
1028799006685	putative Cl binding site [ion binding]; other site
1028799006686	aspartate ring; other site
1028799006687	basic sphincter; other site
1028799006688	hydrophobic gate; other site
1028799006689	periplasmic entrance; other site
1028799006690	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1028799006691	active site
1028799006692	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1028799006693	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1028799006694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006695	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1028799006696	putative substrate translocation pore; other site
1028799006697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006698	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1028799006699	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1028799006700	HlyD family secretion protein; Region: HlyD_3; pfam13437
1028799006701	lipoyl-biotinyl attachment site [posttranslational modification]; other site
1028799006702	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1028799006703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006704	putative substrate translocation pore; other site
1028799006705	Predicted membrane protein [Function unknown]; Region: COG4640
1028799006706	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1028799006707	MarR family; Region: MarR_2; pfam12802
1028799006708	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1028799006709	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1028799006710	putative active site [active]
1028799006711	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1028799006712	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1028799006713	Walker A/P-loop; other site
1028799006714	ATP binding site [chemical binding]; other site
1028799006715	Q-loop/lid; other site
1028799006716	ABC transporter signature motif; other site
1028799006717	Walker B; other site
1028799006718	D-loop; other site
1028799006719	H-loop/switch region; other site
1028799006720	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1028799006721	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1028799006722	FtsX-like permease family; Region: FtsX; pfam02687
1028799006723	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1028799006724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799006725	active site
1028799006726	phosphorylation site [posttranslational modification]
1028799006727	intermolecular recognition site; other site
1028799006728	dimerization interface [polypeptide binding]; other site
1028799006729	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1028799006730	DNA binding site [nucleotide binding]
1028799006731	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1028799006732	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1028799006733	dimerization interface [polypeptide binding]; other site
1028799006734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1028799006735	dimer interface [polypeptide binding]; other site
1028799006736	phosphorylation site [posttranslational modification]
1028799006737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799006738	ATP binding site [chemical binding]; other site
1028799006739	Mg2+ binding site [ion binding]; other site
1028799006740	G-X-G motif; other site
1028799006741	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1028799006742	LytTr DNA-binding domain; Region: LytTR; smart00850
1028799006743	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1028799006744	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
1028799006745	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1028799006746	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1028799006747	L-lactate permease; Region: Lactate_perm; cl00701
1028799006748	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1028799006749	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799006750	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1028799006751	Coenzyme A binding pocket [chemical binding]; other site
1028799006752	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1028799006753	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1028799006754	NAD(P) binding site [chemical binding]; other site
1028799006755	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799006756	Coenzyme A binding pocket [chemical binding]; other site
1028799006757	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1028799006758	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1028799006759	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799006760	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
1028799006761	Predicted membrane protein [Function unknown]; Region: COG1511
1028799006762	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1028799006763	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1028799006764	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1028799006765	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1028799006766	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1028799006767	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1028799006768	Cl binding site [ion binding]; other site
1028799006769	oligomer interface [polypeptide binding]; other site
1028799006770	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1028799006771	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1028799006772	active site turn [active]
1028799006773	phosphorylation site [posttranslational modification]
1028799006774	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1028799006775	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1028799006776	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1028799006777	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1028799006778	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1028799006779	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1028799006780	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1028799006781	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1028799006782	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
1028799006783	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1028799006784	MarR family; Region: MarR_2; pfam12802
1028799006785	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1028799006786	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
1028799006787	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1028799006788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006789	putative substrate translocation pore; other site
1028799006790	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1028799006791	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1028799006792	DNA binding residues [nucleotide binding]
1028799006793	dimer interface [polypeptide binding]; other site
1028799006794	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1028799006795	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1028799006796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799006797	active site
1028799006798	phosphorylation site [posttranslational modification]
1028799006799	intermolecular recognition site; other site
1028799006800	dimerization interface [polypeptide binding]; other site
1028799006801	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1028799006802	DNA binding residues [nucleotide binding]
1028799006803	dimerization interface [polypeptide binding]; other site
1028799006804	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1028799006805	Histidine kinase; Region: HisKA_3; pfam07730
1028799006806	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799006807	ATP binding site [chemical binding]; other site
1028799006808	Mg2+ binding site [ion binding]; other site
1028799006809	G-X-G motif; other site
1028799006810	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1028799006811	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1028799006812	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1028799006813	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1028799006814	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1028799006815	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1028799006816	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1028799006817	[4Fe-4S] binding site [ion binding]; other site
1028799006818	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1028799006819	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1028799006820	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1028799006821	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1028799006822	molybdopterin cofactor binding site; other site
1028799006823	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1028799006824	active site
1028799006825	SAM binding site [chemical binding]; other site
1028799006826	homodimer interface [polypeptide binding]; other site
1028799006827	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1028799006828	[2Fe-2S] cluster binding site [ion binding]; other site
1028799006829	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1028799006830	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1028799006831	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1028799006832	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1028799006833	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1028799006834	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1028799006835	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1028799006836	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1028799006837	putative active site [active]
1028799006838	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1028799006839	active site
1028799006840	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1028799006841	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799006842	Coenzyme A binding pocket [chemical binding]; other site
1028799006843	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1028799006844	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1028799006845	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1028799006846	putative hydrophobic ligand binding site [chemical binding]; other site
1028799006847	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1028799006848	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1028799006849	intersubunit interface [polypeptide binding]; other site
1028799006850	YodA lipocalin-like domain; Region: YodA; pfam09223
1028799006851	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
1028799006852	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1028799006853	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1028799006854	Thioredoxin; Region: Thioredoxin_4; cl17273
1028799006855	FemAB family; Region: FemAB; pfam02388
1028799006856	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1028799006857	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1028799006858	Walker A/P-loop; other site
1028799006859	ATP binding site [chemical binding]; other site
1028799006860	Q-loop/lid; other site
1028799006861	ABC transporter signature motif; other site
1028799006862	Walker B; other site
1028799006863	D-loop; other site
1028799006864	H-loop/switch region; other site
1028799006865	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1028799006866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799006867	dimer interface [polypeptide binding]; other site
1028799006868	conserved gate region; other site
1028799006869	putative PBP binding loops; other site
1028799006870	ABC-ATPase subunit interface; other site
1028799006871	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1028799006872	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1028799006873	substrate binding pocket [chemical binding]; other site
1028799006874	membrane-bound complex binding site; other site
1028799006875	hinge residues; other site
1028799006876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006877	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799006878	putative substrate translocation pore; other site
1028799006879	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006880	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1028799006881	catalytic core [active]
1028799006882	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1028799006883	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1028799006884	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1028799006885	B domain; Region: B; pfam02216
1028799006886	B domain; Region: B; pfam02216
1028799006887	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
1028799006888	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1028799006889	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1028799006890	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
1028799006891	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
1028799006892	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1028799006893	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1028799006894	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1028799006895	catalytic residue [active]
1028799006896	biotin synthase; Validated; Region: PRK06256
1028799006897	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799006898	FeS/SAM binding site; other site
1028799006899	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1028799006900	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1028799006901	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1028799006902	inhibitor-cofactor binding pocket; inhibition site
1028799006903	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799006904	catalytic residue [active]
1028799006905	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1028799006906	AAA domain; Region: AAA_26; pfam13500
1028799006907	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1028799006908	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1028799006909	Walker A/P-loop; other site
1028799006910	ATP binding site [chemical binding]; other site
1028799006911	Q-loop/lid; other site
1028799006912	ABC transporter signature motif; other site
1028799006913	Walker B; other site
1028799006914	D-loop; other site
1028799006915	H-loop/switch region; other site
1028799006916	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1028799006917	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1028799006918	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799006919	Walker A/P-loop; other site
1028799006920	ATP binding site [chemical binding]; other site
1028799006921	Q-loop/lid; other site
1028799006922	ABC transporter signature motif; other site
1028799006923	Walker B; other site
1028799006924	D-loop; other site
1028799006925	H-loop/switch region; other site
1028799006926	Predicted membrane protein [Function unknown]; Region: COG2246
1028799006927	GtrA-like protein; Region: GtrA; pfam04138
1028799006928	glycerate kinase; Region: TIGR00045
1028799006929	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1028799006930	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1028799006931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006932	putative substrate translocation pore; other site
1028799006933	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1028799006934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990
1028799006935	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1028799006936	putative phosphoesterase; Region: acc_ester; TIGR03729
1028799006937	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1028799006938	Spore germination protein; Region: Spore_permease; cl17796
1028799006939	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1028799006940	Amino acid permease; Region: AA_permease_2; pfam13520
1028799006941	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1028799006942	Beta-lactamase; Region: Beta-lactamase; pfam00144
1028799006943	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1028799006944	extended (e) SDRs; Region: SDR_e; cd08946
1028799006945	NAD(P) binding site [chemical binding]; other site
1028799006946	active site
1028799006947	substrate binding site [chemical binding]; other site
1028799006948	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1028799006949	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1028799006950	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1028799006951	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006952	putative substrate translocation pore; other site
1028799006953	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799006955	dimer interface [polypeptide binding]; other site
1028799006956	conserved gate region; other site
1028799006957	ABC-ATPase subunit interface; other site
1028799006958	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1028799006959	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1028799006960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799006961	dimer interface [polypeptide binding]; other site
1028799006962	conserved gate region; other site
1028799006963	putative PBP binding loops; other site
1028799006964	ABC-ATPase subunit interface; other site
1028799006965	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1028799006966	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1028799006967	Walker A/P-loop; other site
1028799006968	ATP binding site [chemical binding]; other site
1028799006969	Q-loop/lid; other site
1028799006970	ABC transporter signature motif; other site
1028799006971	Walker B; other site
1028799006972	D-loop; other site
1028799006973	H-loop/switch region; other site
1028799006974	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1028799006975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1028799006976	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1028799006977	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1028799006978	amino acid transporter; Region: 2A0306; TIGR00909
1028799006979	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1028799006980	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1028799006981	substrate binding pocket [chemical binding]; other site
1028799006982	catalytic triad [active]
1028799006983	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1028799006984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799006985	putative substrate translocation pore; other site
1028799006986	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1028799006987	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1028799006988	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1028799006989	Walker A/P-loop; other site
1028799006990	ATP binding site [chemical binding]; other site
1028799006991	Q-loop/lid; other site
1028799006992	ABC transporter signature motif; other site
1028799006993	Walker B; other site
1028799006994	D-loop; other site
1028799006995	H-loop/switch region; other site
1028799006996	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1028799006997	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1028799006998	oligomer interface [polypeptide binding]; other site
1028799006999	active site
1028799007000	metal binding site [ion binding]; metal-binding site
1028799007001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115
1028799007002	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1028799007003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
1028799007004	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1028799007005	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1028799007006	active site
1028799007007	FMN binding site [chemical binding]; other site
1028799007008	substrate binding site [chemical binding]; other site
1028799007009	3Fe-4S cluster binding site [ion binding]; other site
1028799007010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799007011	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799007012	putative substrate translocation pore; other site
1028799007013	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1028799007014	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799007015	Walker A/P-loop; other site
1028799007016	ATP binding site [chemical binding]; other site
1028799007017	Q-loop/lid; other site
1028799007018	ABC transporter signature motif; other site
1028799007019	Walker B; other site
1028799007020	D-loop; other site
1028799007021	H-loop/switch region; other site
1028799007022	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1028799007023	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1028799007024	Walker A/P-loop; other site
1028799007025	ATP binding site [chemical binding]; other site
1028799007026	Q-loop/lid; other site
1028799007027	ABC transporter signature motif; other site
1028799007028	Walker B; other site
1028799007029	D-loop; other site
1028799007030	H-loop/switch region; other site
1028799007031	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1028799007032	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1028799007033	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1028799007034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799007035	dimer interface [polypeptide binding]; other site
1028799007036	conserved gate region; other site
1028799007037	putative PBP binding loops; other site
1028799007038	ABC-ATPase subunit interface; other site
1028799007039	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1028799007040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1028799007041	dimer interface [polypeptide binding]; other site
1028799007042	conserved gate region; other site
1028799007043	putative PBP binding loops; other site
1028799007044	ABC-ATPase subunit interface; other site
1028799007045	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1028799007046	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1028799007047	substrate binding site [chemical binding]; other site
1028799007048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
1028799007049	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
1028799007050	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1028799007051	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1028799007052	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
1028799007053	classical (c) SDRs; Region: SDR_c; cd05233
1028799007054	NAD(P) binding site [chemical binding]; other site
1028799007055	active site
1028799007056	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1028799007057	AbgT putative transporter family; Region: ABG_transport; pfam03806
1028799007058	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1028799007059	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1028799007060	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1028799007061	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1028799007062	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1028799007063	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1028799007064	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1028799007065	classical (c) SDRs; Region: SDR_c; cd05233
1028799007066	NAD(P) binding site [chemical binding]; other site
1028799007067	active site
1028799007068	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
1028799007069	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799007070	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799007071	Protein of unknown function, DUF576; Region: DUF576; pfam04507
1028799007072	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
1028799007073	PLD-like domain; Region: PLDc_2; pfam13091
1028799007074	putative homodimer interface [polypeptide binding]; other site
1028799007075	putative active site [active]
1028799007076	catalytic site [active]
1028799007077	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1028799007078	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1028799007079	ATP binding site [chemical binding]; other site
1028799007080	putative Mg++ binding site [ion binding]; other site
1028799007081	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1028799007082	active site
1028799007083	8-oxo-dGMP binding site [chemical binding]; other site
1028799007084	nudix motif; other site
1028799007085	metal binding site [ion binding]; metal-binding site
1028799007086	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1028799007087	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1028799007088	active site
1028799007089	substrate binding site [chemical binding]; other site
1028799007090	metal binding site [ion binding]; metal-binding site
1028799007091	H+ Antiporter protein; Region: 2A0121; TIGR00900
1028799007092	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799007093	legume lectins; Region: lectin_L-type; cl14058
1028799007094	homotetramer interaction site [polypeptide binding]; other site
1028799007095	carbohydrate binding site [chemical binding]; other site
1028799007096	metal binding site [ion binding]; metal-binding site
1028799007097	G5 domain; Region: G5; pfam07501
1028799007098	G5 domain; Region: G5; pfam07501
1028799007099	G5 domain; Region: G5; pfam07501
1028799007100	G5 domain; Region: G5; pfam07501
1028799007101	G5 domain; Region: G5; pfam07501
1028799007102	G5 domain; Region: G5; pfam07501
1028799007103	G5 domain; Region: G5; pfam07501
1028799007104	G5 domain; Region: G5; pfam07501
1028799007105	G5 domain; Region: G5; pfam07501
1028799007106	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1028799007107	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799007108	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1028799007109	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799007110	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1028799007111	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1028799007112	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1028799007113	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1028799007114	active site
1028799007115	tetramer interface; other site
1028799007116	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799007117	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1028799007118	Fibronectin binding repeat; Region: Fn_bind; pfam02986
1028799007119	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1028799007120	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799007121	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1028799007122	Fibronectin binding repeat; Region: Fn_bind; pfam02986
1028799007123	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1028799007124	GntP family permease; Region: GntP_permease; pfam02447
1028799007125	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1028799007126	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1028799007127	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1028799007128	N- and C-terminal domain interface [polypeptide binding]; other site
1028799007129	active site
1028799007130	catalytic site [active]
1028799007131	metal binding site [ion binding]; metal-binding site
1028799007132	carbohydrate binding site [chemical binding]; other site
1028799007133	ATP binding site [chemical binding]; other site
1028799007134	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1028799007135	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1028799007136	DNA-binding site [nucleotide binding]; DNA binding site
1028799007137	FCD domain; Region: FCD; pfam07729
1028799007138	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1028799007139	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1028799007140	DNA binding residues [nucleotide binding]
1028799007141	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1028799007142	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1028799007143	synthetase active site [active]
1028799007144	NTP binding site [chemical binding]; other site
1028799007145	metal binding site [ion binding]; metal-binding site
1028799007146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1028799007147	Predicted membrane protein [Function unknown]; Region: COG1289
1028799007148	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1028799007149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799007150	D-galactonate transporter; Region: 2A0114; TIGR00893
1028799007151	putative substrate translocation pore; other site
1028799007152	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1028799007153	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1028799007154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1028799007155	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1028799007156	putative substrate translocation pore; other site
1028799007157	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1028799007158	MarR family; Region: MarR; pfam01047
1028799007159	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1028799007160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799007161	Walker A/P-loop; other site
1028799007162	ATP binding site [chemical binding]; other site
1028799007163	Q-loop/lid; other site
1028799007164	ABC transporter signature motif; other site
1028799007165	Walker B; other site
1028799007166	D-loop; other site
1028799007167	H-loop/switch region; other site
1028799007168	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1028799007169	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1028799007170	Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855
1028799007171	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1028799007172	Predicted esterase [General function prediction only]; Region: COG0400
1028799007173	putative hydrolase; Provisional; Region: PRK11460
1028799007174	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1028799007175	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1028799007176	Zn binding site [ion binding]; other site
1028799007177	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1028799007178	Zn binding site [ion binding]; other site
1028799007179	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1028799007180	MarR family; Region: MarR; pfam01047
1028799007181	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1028799007182	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1028799007183	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1028799007184	putative metal binding site [ion binding]; other site
1028799007185	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1028799007186	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1028799007187	dimer interface [polypeptide binding]; other site
1028799007188	FMN binding site [chemical binding]; other site
1028799007189	D-lactate dehydrogenase; Provisional; Region: PRK12480
1028799007190	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1028799007191	homodimer interface [polypeptide binding]; other site
1028799007192	ligand binding site [chemical binding]; other site
1028799007193	NAD binding site [chemical binding]; other site
1028799007194	catalytic site [active]
1028799007195	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1028799007196	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1028799007197	active site
1028799007198	motif I; other site
1028799007199	motif II; other site
1028799007200	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1028799007201	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1028799007202	Walker A/P-loop; other site
1028799007203	ATP binding site [chemical binding]; other site
1028799007204	Q-loop/lid; other site
1028799007205	ABC transporter signature motif; other site
1028799007206	Walker B; other site
1028799007207	D-loop; other site
1028799007208	H-loop/switch region; other site
1028799007209	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
1028799007210	active site
1028799007211	catalytic site [active]
1028799007212	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1028799007213	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799007214	Coenzyme A binding pocket [chemical binding]; other site
1028799007215	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1028799007216	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1028799007217	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1028799007218	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1028799007219	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1028799007220	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1028799007221	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1028799007222	EamA-like transporter family; Region: EamA; pfam00892
1028799007223	EamA-like transporter family; Region: EamA; pfam00892
1028799007224	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1028799007225	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1028799007226	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1028799007227	catalytic residues [active]
1028799007228	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1028799007229	active site
1028799007230	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1028799007231	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1028799007232	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1028799007233	active site turn [active]
1028799007234	phosphorylation site [posttranslational modification]
1028799007235	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1028799007236	HPr interaction site; other site
1028799007237	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1028799007238	active site
1028799007239	phosphorylation site [posttranslational modification]
1028799007240	pyruvate oxidase; Provisional; Region: PRK08611
1028799007241	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1028799007242	PYR/PP interface [polypeptide binding]; other site
1028799007243	tetramer interface [polypeptide binding]; other site
1028799007244	dimer interface [polypeptide binding]; other site
1028799007245	TPP binding site [chemical binding]; other site
1028799007246	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1028799007247	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1028799007248	TPP-binding site [chemical binding]; other site
1028799007249	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1028799007250	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1028799007251	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1028799007252	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1028799007253	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1028799007254	putative dimerization interface [polypeptide binding]; other site
1028799007255	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1028799007256	Surface antigen [General function prediction only]; Region: COG3942
1028799007257	CHAP domain; Region: CHAP; pfam05257
1028799007258	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1028799007259	homodimer interface [polypeptide binding]; other site
1028799007260	catalytic residues [active]
1028799007261	NAD binding site [chemical binding]; other site
1028799007262	substrate binding pocket [chemical binding]; other site
1028799007263	flexible flap; other site
1028799007264	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1028799007265	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1028799007266	dimer interface [polypeptide binding]; other site
1028799007267	active site
1028799007268	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1028799007269	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1028799007270	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1028799007271	DNA binding site [nucleotide binding]
1028799007272	active site
1028799007273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799007274	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1028799007275	Walker A motif; other site
1028799007276	ATP binding site [chemical binding]; other site
1028799007277	Walker B motif; other site
1028799007278	arginine finger; other site
1028799007279	UvrB/uvrC motif; Region: UVR; pfam02151
1028799007280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1028799007281	Walker A motif; other site
1028799007282	ATP binding site [chemical binding]; other site
1028799007283	Walker B motif; other site
1028799007284	arginine finger; other site
1028799007285	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1028799007286	Virus attachment protein p12 family; Region: P12; pfam12669
1028799007287	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1028799007288	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1028799007289	G1 box; other site
1028799007290	GTP/Mg2+ binding site [chemical binding]; other site
1028799007291	Switch I region; other site
1028799007292	G2 box; other site
1028799007293	G3 box; other site
1028799007294	Switch II region; other site
1028799007295	G4 box; other site
1028799007296	G5 box; other site
1028799007297	Nucleoside recognition; Region: Gate; pfam07670
1028799007298	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1028799007299	Nucleoside recognition; Region: Gate; pfam07670
1028799007300	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1028799007301	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1028799007302	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1028799007303	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1028799007304	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1028799007305	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1028799007306	Glutamate binding site [chemical binding]; other site
1028799007307	homodimer interface [polypeptide binding]; other site
1028799007308	NAD binding site [chemical binding]; other site
1028799007309	catalytic residues [active]
1028799007310	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
1028799007311	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1028799007312	active site
1028799007313	substrate binding site [chemical binding]; other site
1028799007314	trimer interface [polypeptide binding]; other site
1028799007315	CoA binding site [chemical binding]; other site
1028799007316	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1028799007317	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1028799007318	metal-binding site [ion binding]
1028799007319	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1028799007320	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1028799007321	metal-binding site [ion binding]
1028799007322	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1028799007323	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1028799007324	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1028799007325	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1028799007326	metal-binding site [ion binding]
1028799007327	D-lactate dehydrogenase; Validated; Region: PRK08605
1028799007328	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1028799007329	homodimer interface [polypeptide binding]; other site
1028799007330	ligand binding site [chemical binding]; other site
1028799007331	NAD binding site [chemical binding]; other site
1028799007332	catalytic site [active]
1028799007333	transaminase; Reviewed; Region: PRK08068
1028799007334	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1028799007335	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799007336	homodimer interface [polypeptide binding]; other site
1028799007337	catalytic residue [active]
1028799007338	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1028799007339	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1028799007340	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1028799007341	active site lid residues [active]
1028799007342	substrate binding pocket [chemical binding]; other site
1028799007343	catalytic residues [active]
1028799007344	substrate-Mg2+ binding site; other site
1028799007345	aspartate-rich region 1; other site
1028799007346	aspartate-rich region 2; other site
1028799007347	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1028799007348	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1028799007349	active site
1028799007350	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1028799007351	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1028799007352	Surface antigen [General function prediction only]; Region: COG3942
1028799007353	CHAP domain; Region: CHAP; pfam05257
1028799007354	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1028799007355	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1028799007356	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1028799007357	catalytic triad [active]
1028799007358	catalytic triad [active]
1028799007359	oxyanion hole [active]
1028799007360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799007361	Coenzyme A binding pocket [chemical binding]; other site
1028799007362	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1028799007363	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1028799007364	catalytic residue [active]
1028799007365	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1028799007366	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1028799007367	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1028799007368	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1028799007369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
1028799007370	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1028799007371	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1028799007372	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1028799007373	NmrA-like family; Region: NmrA; pfam05368
1028799007374	NADP binding site [chemical binding]; other site
1028799007375	active site
1028799007376	regulatory binding site [polypeptide binding]; other site
1028799007377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367
1028799007378	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1028799007379	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1028799007380	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
1028799007381	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1028799007382	NAD(P) binding site [chemical binding]; other site
1028799007383	active site
1028799007384	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1028799007385	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1028799007386	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1028799007387	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1028799007388	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1028799007389	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1028799007390	Nucleoside recognition; Region: Gate; pfam07670
1028799007391	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1028799007392	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1028799007393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
1028799007394	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1028799007395	Phosphotransferase enzyme family; Region: APH; pfam01636
1028799007396	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1028799007397	active site
1028799007398	ATP binding site [chemical binding]; other site
1028799007399	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1028799007400	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1028799007401	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1028799007402	quinone interaction residues [chemical binding]; other site
1028799007403	active site
1028799007404	catalytic residues [active]
1028799007405	FMN binding site [chemical binding]; other site
1028799007406	substrate binding site [chemical binding]; other site
1028799007407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1028799007408	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1028799007409	dimer interface [polypeptide binding]; other site
1028799007410	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1028799007411	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1028799007412	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1028799007413	Predicted acyl esterases [General function prediction only]; Region: COG2936
1028799007414	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1028799007415	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1028799007416	tetramerization interface [polypeptide binding]; other site
1028799007417	active site
1028799007418	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1028799007419	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1028799007420	active site
1028799007421	ATP-binding site [chemical binding]; other site
1028799007422	pantoate-binding site; other site
1028799007423	HXXH motif; other site
1028799007424	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1028799007425	oligomerization interface [polypeptide binding]; other site
1028799007426	active site
1028799007427	metal binding site [ion binding]; metal-binding site
1028799007428	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1028799007429	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1028799007430	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1028799007431	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1028799007432	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1028799007433	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1028799007434	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1028799007435	NAD binding site [chemical binding]; other site
1028799007436	dimer interface [polypeptide binding]; other site
1028799007437	substrate binding site [chemical binding]; other site
1028799007438	amino acid transporter; Region: 2A0306; TIGR00909
1028799007439	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1028799007440	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
1028799007441	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1028799007442	inhibitor-cofactor binding pocket; inhibition site
1028799007443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799007444	catalytic residue [active]
1028799007445	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
1028799007446	catalytic residue [active]
1028799007447	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
1028799007448	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1028799007449	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1028799007450	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1028799007451	acyl-activating enzyme (AAE) consensus motif; other site
1028799007452	AMP binding site [chemical binding]; other site
1028799007453	active site
1028799007454	CoA binding site [chemical binding]; other site
1028799007455	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1028799007456	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1028799007457	choline dehydrogenase; Validated; Region: PRK02106
1028799007458	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1028799007459	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1028799007460	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1028799007461	tetramerization interface [polypeptide binding]; other site
1028799007462	NAD(P) binding site [chemical binding]; other site
1028799007463	catalytic residues [active]
1028799007464	Predicted transcriptional regulators [Transcription]; Region: COG1510
1028799007465	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1028799007466	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1028799007467	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1028799007468	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1028799007469	FeS/SAM binding site; other site
1028799007470	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
1028799007471	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1028799007472	effector binding site; other site
1028799007473	active site
1028799007474	Zn binding site [ion binding]; other site
1028799007475	glycine loop; other site
1028799007476	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1028799007477	Citrate transporter; Region: CitMHS; pfam03600
1028799007478	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
1028799007479	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1028799007480	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1028799007481	Flavodoxin; Region: Flavodoxin_1; pfam00258
1028799007482	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1028799007483	FAD binding pocket [chemical binding]; other site
1028799007484	FAD binding motif [chemical binding]; other site
1028799007485	catalytic residues [active]
1028799007486	NAD binding pocket [chemical binding]; other site
1028799007487	phosphate binding motif [ion binding]; other site
1028799007488	beta-alpha-beta structure motif; other site
1028799007489	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1028799007490	catalytic residues [active]
1028799007491	dimer interface [polypeptide binding]; other site
1028799007492	FtsX-like permease family; Region: FtsX; pfam02687
1028799007493	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1028799007494	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1028799007495	Walker A/P-loop; other site
1028799007496	ATP binding site [chemical binding]; other site
1028799007497	Q-loop/lid; other site
1028799007498	ABC transporter signature motif; other site
1028799007499	Walker B; other site
1028799007500	D-loop; other site
1028799007501	H-loop/switch region; other site
1028799007502	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1028799007503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1028799007504	ATP binding site [chemical binding]; other site
1028799007505	Mg2+ binding site [ion binding]; other site
1028799007506	G-X-G motif; other site
1028799007507	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1028799007508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1028799007509	active site
1028799007510	phosphorylation site [posttranslational modification]
1028799007511	intermolecular recognition site; other site
1028799007512	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1028799007513	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1028799007514	dimer interface [polypeptide binding]; other site
1028799007515	active site
1028799007516	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1028799007517	Protein of unknown function (DUF2648); Region: DUF2648; pfam10855
1028799007518	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1028799007519	MarR family; Region: MarR_2; pfam12802
1028799007520	Predicted esterase [General function prediction only]; Region: COG0627
1028799007521	S-formylglutathione hydrolase; Region: PLN02442
1028799007522	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1028799007523	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1028799007524	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1028799007525	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1028799007526	ligand binding site [chemical binding]; other site
1028799007527	flexible hinge region; other site
1028799007528	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1028799007529	carbamate kinase; Reviewed; Region: PRK12686
1028799007530	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1028799007531	putative substrate binding site [chemical binding]; other site
1028799007532	nucleotide binding site [chemical binding]; other site
1028799007533	nucleotide binding site [chemical binding]; other site
1028799007534	homodimer interface [polypeptide binding]; other site
1028799007535	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1028799007536	ornithine carbamoyltransferase; Validated; Region: PRK02102
1028799007537	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1028799007538	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1028799007539	arginine deiminase; Provisional; Region: PRK01388
1028799007540	Arginine repressor [Transcription]; Region: ArgR; COG1438
1028799007541	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1028799007542	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1028799007543	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1028799007544	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1028799007545	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1028799007546	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1028799007547	active site
1028799007548	Zn binding site [ion binding]; other site
1028799007549	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1028799007550	HTH domain; Region: HTH_11; pfam08279
1028799007551	PRD domain; Region: PRD; pfam00874
1028799007552	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1028799007553	active site
1028799007554	P-loop; other site
1028799007555	phosphorylation site [posttranslational modification]
1028799007556	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1028799007557	active site
1028799007558	phosphorylation site [posttranslational modification]
1028799007559	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1028799007560	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1028799007561	active site
1028799007562	P-loop; other site
1028799007563	phosphorylation site [posttranslational modification]
1028799007564	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1028799007565	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1028799007566	active site
1028799007567	phosphorylation site [posttranslational modification]
1028799007568	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1028799007569	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1028799007570	Predicted membrane protein [Function unknown]; Region: COG1511
1028799007571	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1028799007572	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1028799007573	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
1028799007574	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1028799007575	CHAP domain; Region: CHAP; pfam05257
1028799007576	Isochorismatase family; Region: Isochorismatase; pfam00857
1028799007577	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1028799007578	catalytic triad [active]
1028799007579	conserved cis-peptide bond; other site
1028799007580	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1028799007581	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1028799007582	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1028799007583	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1028799007584	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
1028799007585	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1028799007586	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1028799007587	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1028799007588	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1028799007589	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1028799007590	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1028799007591	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
1028799007592	SecY translocase; Region: SecY; pfam00344
1028799007593	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1028799007594	legume lectins; Region: lectin_L-type; cd01951
1028799007595	homotetramer interaction site [polypeptide binding]; other site
1028799007596	carbohydrate binding site [chemical binding]; other site
1028799007597	metal binding site [ion binding]; metal-binding site
1028799007598	Putative Ig domain; Region: He_PIG; pfam05345
1028799007599	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1028799007600	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
1028799007601	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1028799007602	methionine sulfoxide reductase A; Provisional; Region: PRK05528
1028799007603	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1028799007604	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1028799007605	Coenzyme A binding pocket [chemical binding]; other site
1028799007606	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1028799007607	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1028799007608	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1028799007609	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1028799007610	Chain length determinant protein; Region: Wzz; cl15801
1028799007611	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1028799007612	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1028799007613	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
1028799007614	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1028799007615	DXD motif; other site
1028799007616	intracellular adhesion protein D; Region: PIA_icaD; TIGR03932
1028799007617	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
1028799007618	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1028799007619	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1028799007620	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1028799007621	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1028799007622	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1028799007623	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1028799007624	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1028799007625	metal binding site [ion binding]; metal-binding site
1028799007626	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1028799007627	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1028799007628	substrate binding site [chemical binding]; other site
1028799007629	glutamase interaction surface [polypeptide binding]; other site
1028799007630	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1028799007631	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1028799007632	catalytic residues [active]
1028799007633	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
1028799007634	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1028799007635	putative active site [active]
1028799007636	oxyanion strand; other site
1028799007637	catalytic triad [active]
1028799007638	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1028799007639	putative active site pocket [active]
1028799007640	4-fold oligomerization interface [polypeptide binding]; other site
1028799007641	metal binding residues [ion binding]; metal-binding site
1028799007642	3-fold/trimer interface [polypeptide binding]; other site
1028799007643	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1028799007644	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1028799007645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1028799007646	homodimer interface [polypeptide binding]; other site
1028799007647	catalytic residue [active]
1028799007648	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1028799007649	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1028799007650	NAD binding site [chemical binding]; other site
1028799007651	dimerization interface [polypeptide binding]; other site
1028799007652	product binding site; other site
1028799007653	substrate binding site [chemical binding]; other site
1028799007654	zinc binding site [ion binding]; other site
1028799007655	catalytic residues [active]
1028799007656	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
1028799007657	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1028799007658	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
1028799007659	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
1028799007660	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1028799007661	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1028799007662	putative active site [active]
1028799007663	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1028799007664	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1028799007665	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1028799007666	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1028799007667	Walker A/P-loop; other site
1028799007668	ATP binding site [chemical binding]; other site
1028799007669	Q-loop/lid; other site
1028799007670	ABC transporter signature motif; other site
1028799007671	Walker B; other site
1028799007672	D-loop; other site
1028799007673	H-loop/switch region; other site
1028799007674	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1028799007675	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1028799007676	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1028799007677	Walker A/P-loop; other site
1028799007678	ATP binding site [chemical binding]; other site
1028799007679	Q-loop/lid; other site
1028799007680	ABC transporter signature motif; other site
1028799007681	Walker B; other site
1028799007682	D-loop; other site
1028799007683	H-loop/switch region; other site
1028799007684	hypothetical protein; Provisional; Region: PRK13661
1028799007685	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1028799007686	Uncharacterized conserved protein [Function unknown]; Region: COG1912
1028799007687	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1028799007688	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1028799007689	Strictosidine synthase; Region: Str_synth; pfam03088
1028799007690	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1028799007691	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1028799007692	active site residue [active]
1028799007693	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1028799007694	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1028799007695	putative substrate binding pocket [chemical binding]; other site
1028799007696	AC domain interface; other site
1028799007697	catalytic triad [active]
1028799007698	AB domain interface; other site
1028799007699	interchain disulfide; other site
1028799007700	hypothetical protein; Validated; Region: PRK07668
1028799007701	Predicted transcriptional regulators [Transcription]; Region: COG1695
1028799007702	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1028799007703	DinB superfamily; Region: DinB_2; pfam12867
1028799007704	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1028799007705	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1028799007706	transmembrane helices; other site
1028799007707	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1028799007708	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1028799007709	hypothetical protein; Provisional; Region: PRK07758
1028799007710	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1028799007711	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1028799007712	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1028799007713	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1028799007714	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1028799007715	Walker A/P-loop; other site
1028799007716	ATP binding site [chemical binding]; other site
1028799007717	Q-loop/lid; other site
1028799007718	ABC transporter signature motif; other site
1028799007719	Walker B; other site
1028799007720	D-loop; other site
1028799007721	H-loop/switch region; other site
1028799007722	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1028799007723	FtsX-like permease family; Region: FtsX; pfam02687
1028799007724	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1028799007725	Integrase core domain; Region: rve; pfam00665
1028799007726	Integrase core domain; Region: rve_3; cl15866
1028799007727	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1028799007728	Integrase core domain; Region: rve_3; cl15866
1028799007729	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1028799007730	DNA-binding site [nucleotide binding]; DNA binding site
1028799007731	RNA-binding motif; other site
1028799007732	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1028799007733	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1028799007734	non-specific DNA binding site [nucleotide binding]; other site
1028799007735	salt bridge; other site
1028799007736	sequence-specific DNA binding site [nucleotide binding]; other site
1028799007737	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1028799007738	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1028799007739	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
1028799007740	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1028799007741	ParB-like nuclease domain; Region: ParBc; pfam02195
1028799007742	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1028799007743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1028799007744	S-adenosylmethionine binding site [chemical binding]; other site
1028799007745	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1028799007746	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1028799007747	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1028799007748	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1028799007749	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1028799007750	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1028799007751	G1 box; other site
1028799007752	GTP/Mg2+ binding site [chemical binding]; other site
1028799007753	Switch I region; other site
1028799007754	G2 box; other site
1028799007755	Switch II region; other site
1028799007756	G3 box; other site
1028799007757	G4 box; other site
1028799007758	G5 box; other site
1028799007759	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1028799007760	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1028799007761	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399