-- dump date 20140620_075702 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1406863000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1406863000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1406863000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863000004 Walker A motif; other site 1406863000005 ATP binding site [chemical binding]; other site 1406863000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1406863000007 Walker B motif; other site 1406863000008 arginine finger; other site 1406863000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1406863000010 DnaA box-binding interface [nucleotide binding]; other site 1406863000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1406863000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1406863000013 putative DNA binding surface [nucleotide binding]; other site 1406863000014 dimer interface [polypeptide binding]; other site 1406863000015 beta-clamp/clamp loader binding surface; other site 1406863000016 beta-clamp/translesion DNA polymerase binding surface; other site 1406863000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1406863000018 recF protein; Region: recf; TIGR00611 1406863000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1406863000020 Walker A/P-loop; other site 1406863000021 ATP binding site [chemical binding]; other site 1406863000022 Q-loop/lid; other site 1406863000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863000024 ABC transporter signature motif; other site 1406863000025 Walker B; other site 1406863000026 D-loop; other site 1406863000027 H-loop/switch region; other site 1406863000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1406863000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863000030 Mg2+ binding site [ion binding]; other site 1406863000031 G-X-G motif; other site 1406863000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1406863000033 anchoring element; other site 1406863000034 dimer interface [polypeptide binding]; other site 1406863000035 ATP binding site [chemical binding]; other site 1406863000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1406863000037 active site 1406863000038 putative metal-binding site [ion binding]; other site 1406863000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1406863000040 DNA gyrase subunit A; Validated; Region: PRK05560 1406863000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1406863000042 CAP-like domain; other site 1406863000043 active site 1406863000044 primary dimer interface [polypeptide binding]; other site 1406863000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1406863000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1406863000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1406863000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1406863000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1406863000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1406863000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1406863000052 putative substrate binding site [chemical binding]; other site 1406863000053 putative ATP binding site [chemical binding]; other site 1406863000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1406863000055 active sites [active] 1406863000056 tetramer interface [polypeptide binding]; other site 1406863000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 1406863000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1406863000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1406863000060 dimer interface [polypeptide binding]; other site 1406863000061 active site 1406863000062 motif 1; other site 1406863000063 motif 2; other site 1406863000064 motif 3; other site 1406863000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1406863000066 Predicted membrane protein [Function unknown]; Region: COG4392 1406863000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1406863000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1406863000069 Predicted membrane protein [Function unknown]; Region: COG4241 1406863000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1406863000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1406863000072 DHH family; Region: DHH; pfam01368 1406863000073 DHHA1 domain; Region: DHHA1; pfam02272 1406863000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1406863000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1406863000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1406863000077 replicative DNA helicase; Region: DnaB; TIGR00665 1406863000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1406863000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1406863000080 Walker A motif; other site 1406863000081 ATP binding site [chemical binding]; other site 1406863000082 Walker B motif; other site 1406863000083 DNA binding loops [nucleotide binding] 1406863000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1406863000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1406863000086 GDP-binding site [chemical binding]; other site 1406863000087 ACT binding site; other site 1406863000088 IMP binding site; other site 1406863000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1406863000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863000091 active site 1406863000092 phosphorylation site [posttranslational modification] 1406863000093 intermolecular recognition site; other site 1406863000094 dimerization interface [polypeptide binding]; other site 1406863000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1406863000096 DNA binding site [nucleotide binding] 1406863000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1406863000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1406863000099 dimerization interface [polypeptide binding]; other site 1406863000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1406863000101 putative active site [active] 1406863000102 heme pocket [chemical binding]; other site 1406863000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1406863000104 dimer interface [polypeptide binding]; other site 1406863000105 phosphorylation site [posttranslational modification] 1406863000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863000107 ATP binding site [chemical binding]; other site 1406863000108 Mg2+ binding site [ion binding]; other site 1406863000109 G-X-G motif; other site 1406863000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1406863000111 YycH protein; Region: YycH; pfam07435 1406863000112 YycH protein; Region: YycI; cl02015 1406863000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1406863000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1406863000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1406863000116 putative active site [active] 1406863000117 putative metal binding site [ion binding]; other site 1406863000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1406863000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1406863000120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1406863000121 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1406863000122 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 1406863000123 GIY-YIG motif/motif A; other site 1406863000124 putative active site [active] 1406863000125 putative metal binding site [ion binding]; other site 1406863000126 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1406863000127 active site 1406863000128 DNA binding site [nucleotide binding] 1406863000129 catalytic site [active] 1406863000130 Phage associated DNA primase [General function prediction only]; Region: COG3378 1406863000131 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1406863000132 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1406863000133 catalytic residues [active] 1406863000134 catalytic nucleophile [active] 1406863000135 Recombinase; Region: Recombinase; pfam07508 1406863000136 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1406863000137 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1406863000138 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 1406863000139 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1406863000140 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1406863000141 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 1406863000142 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1406863000143 MPN+ (JAMM) motif; other site 1406863000144 Zinc-binding site [ion binding]; other site 1406863000145 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1406863000146 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1406863000147 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 1406863000148 Int/Topo IB signature motif; other site 1406863000149 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1406863000150 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1406863000151 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1406863000152 active site 1406863000153 DNA binding site [nucleotide binding] 1406863000154 Int/Topo IB signature motif; other site 1406863000155 aminoglycoside resistance protein; Provisional; Region: PRK13746 1406863000156 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1406863000157 active site 1406863000158 NTP binding site [chemical binding]; other site 1406863000159 metal binding triad [ion binding]; metal-binding site 1406863000160 antibiotic binding site [chemical binding]; other site 1406863000161 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1406863000162 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1406863000163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863000164 S-adenosylmethionine binding site [chemical binding]; other site 1406863000165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863000166 S-adenosylmethionine binding site [chemical binding]; other site 1406863000167 WYL domain; Region: WYL; pfam13280 1406863000168 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1406863000169 Lysis protein; Region: Lysis_col; pfam02402 1406863000170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863000171 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1406863000172 ATP binding site [chemical binding]; other site 1406863000173 putative Mg++ binding site [ion binding]; other site 1406863000174 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1406863000175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1406863000176 Integrase core domain; Region: rve; pfam00665 1406863000177 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1406863000178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863000179 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1406863000180 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 1406863000181 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1406863000182 DNA binding residues [nucleotide binding] 1406863000183 dimer interface [polypeptide binding]; other site 1406863000184 mercury binding site [ion binding]; other site 1406863000185 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1406863000186 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1406863000187 catalytic residues [active] 1406863000188 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1406863000189 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1406863000190 metal-binding site [ion binding] 1406863000191 mercuric reductase; Region: MerA; TIGR02053 1406863000192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863000193 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1406863000194 alkylmercury lyase; Provisional; Region: PRK13239 1406863000195 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 1406863000196 Alkylmercury lyase; Region: MerB; pfam03243 1406863000197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1406863000198 Integrase core domain; Region: rve; pfam00665 1406863000199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863000200 putative substrate translocation pore; other site 1406863000201 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1406863000202 Replication initiation factor; Region: Rep_trans; pfam02486 1406863000203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1406863000204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1406863000205 Integrase core domain; Region: rve; pfam00665 1406863000206 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1406863000207 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1406863000208 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1406863000209 putative active site [active] 1406863000210 catalytic site [active] 1406863000211 putative metal binding site [ion binding]; other site 1406863000212 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1406863000213 putative active site [active] 1406863000214 putative catalytic site [active] 1406863000215 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1406863000216 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1406863000217 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1406863000218 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1406863000219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1406863000220 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1406863000221 Predicted transcriptional regulator [Transcription]; Region: COG3682 1406863000222 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1406863000223 MarR family; Region: MarR_2; pfam12802 1406863000224 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1406863000225 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1406863000226 nucleotide binding site [chemical binding]; other site 1406863000227 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1406863000228 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1406863000229 active site residue [active] 1406863000230 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1406863000231 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1406863000232 active site residue [active] 1406863000233 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 1406863000234 CPxP motif; other site 1406863000235 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1406863000236 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1406863000237 putative homodimer interface [polypeptide binding]; other site 1406863000238 putative homotetramer interface [polypeptide binding]; other site 1406863000239 putative metal binding site [ion binding]; other site 1406863000240 putative homodimer-homodimer interface [polypeptide binding]; other site 1406863000241 putative allosteric switch controlling residues; other site 1406863000242 Cadmium resistance transporter; Region: Cad; pfam03596 1406863000243 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1406863000244 metal-binding site [ion binding] 1406863000245 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1406863000246 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1406863000247 metal-binding site [ion binding] 1406863000248 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1406863000249 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1406863000250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1406863000251 dimerization interface [polypeptide binding]; other site 1406863000252 putative DNA binding site [nucleotide binding]; other site 1406863000253 putative Zn2+ binding site [ion binding]; other site 1406863000254 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1406863000255 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1406863000256 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1406863000257 active site 1406863000258 DNA binding site [nucleotide binding] 1406863000259 Int/Topo IB signature motif; other site 1406863000260 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1406863000261 MPN+ (JAMM) motif; other site 1406863000262 Zinc-binding site [ion binding]; other site 1406863000263 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1406863000264 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1406863000265 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1406863000266 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1406863000267 catalytic residues [active] 1406863000268 catalytic nucleophile [active] 1406863000269 Presynaptic Site I dimer interface [polypeptide binding]; other site 1406863000270 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1406863000271 Synaptic Flat tetramer interface [polypeptide binding]; other site 1406863000272 Synaptic Site I dimer interface [polypeptide binding]; other site 1406863000273 DNA binding site [nucleotide binding] 1406863000274 Recombinase; Region: Recombinase; pfam07508 1406863000275 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1406863000276 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1406863000277 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1406863000278 catalytic residues [active] 1406863000279 catalytic nucleophile [active] 1406863000280 Recombinase; Region: Recombinase; pfam07508 1406863000281 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1406863000282 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1406863000283 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1406863000284 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1406863000285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863000286 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1406863000287 Walker A motif; other site 1406863000288 ATP binding site [chemical binding]; other site 1406863000289 Walker B motif; other site 1406863000290 arginine finger; other site 1406863000291 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 1406863000292 transposase; Provisional; Region: PRK06526 1406863000293 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1406863000294 active site 1406863000295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863000296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863000297 putative substrate translocation pore; other site 1406863000298 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1406863000299 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1406863000300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1406863000301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1406863000302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863000303 Coenzyme A binding pocket [chemical binding]; other site 1406863000304 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1406863000305 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1406863000306 FMN binding site [chemical binding]; other site 1406863000307 active site 1406863000308 catalytic residues [active] 1406863000309 substrate binding site [chemical binding]; other site 1406863000310 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1406863000311 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1406863000312 Part of AAA domain; Region: AAA_19; pfam13245 1406863000313 AAA domain; Region: AAA_12; pfam13087 1406863000314 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1406863000315 active site 1406863000316 catalytic site [active] 1406863000317 putative metal binding site [ion binding]; other site 1406863000318 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1406863000319 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1406863000320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1406863000321 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1406863000322 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1406863000323 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1406863000324 metal binding site [ion binding]; metal-binding site 1406863000325 dimer interface [polypeptide binding]; other site 1406863000326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863000327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863000328 putative substrate translocation pore; other site 1406863000329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863000330 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1406863000331 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1406863000332 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1406863000333 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1406863000334 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1406863000335 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1406863000336 L-lactate permease; Region: Lactate_perm; cl00701 1406863000337 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863000338 B domain; Region: B; pfam02216 1406863000339 B domain; Region: B; pfam02216 1406863000340 B domain; Region: B; pfam02216 1406863000341 B domain; Region: B; pfam02216 1406863000342 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1406863000343 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863000344 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1406863000345 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863000346 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1406863000347 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1406863000348 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863000349 ABC-ATPase subunit interface; other site 1406863000350 dimer interface [polypeptide binding]; other site 1406863000351 putative PBP binding regions; other site 1406863000352 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1406863000353 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863000354 ABC-ATPase subunit interface; other site 1406863000355 dimer interface [polypeptide binding]; other site 1406863000356 putative PBP binding regions; other site 1406863000357 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1406863000358 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1406863000359 siderophore binding site; other site 1406863000360 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1406863000361 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1406863000362 dimer interface [polypeptide binding]; other site 1406863000363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863000364 catalytic residue [active] 1406863000365 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1406863000366 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1406863000367 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1406863000368 IucA / IucC family; Region: IucA_IucC; pfam04183 1406863000369 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1406863000370 drug efflux system protein MdtG; Provisional; Region: PRK09874 1406863000371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863000372 putative substrate translocation pore; other site 1406863000373 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1406863000374 IucA / IucC family; Region: IucA_IucC; pfam04183 1406863000375 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1406863000376 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1406863000377 IucA / IucC family; Region: IucA_IucC; pfam04183 1406863000378 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1406863000379 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1406863000380 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1406863000381 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1406863000382 dimer interface [polypeptide binding]; other site 1406863000383 active site 1406863000384 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1406863000385 catalytic residues [active] 1406863000386 substrate binding site [chemical binding]; other site 1406863000387 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1406863000388 ParB-like nuclease domain; Region: ParBc; pfam02195 1406863000389 acetoin reductase; Validated; Region: PRK08643 1406863000390 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1406863000391 NAD binding site [chemical binding]; other site 1406863000392 homotetramer interface [polypeptide binding]; other site 1406863000393 homodimer interface [polypeptide binding]; other site 1406863000394 active site 1406863000395 substrate binding site [chemical binding]; other site 1406863000396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1406863000397 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1406863000398 NAD(P) binding site [chemical binding]; other site 1406863000399 active site 1406863000400 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1406863000401 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1406863000402 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1406863000403 putative ADP-binding pocket [chemical binding]; other site 1406863000404 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1406863000405 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1406863000406 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1406863000407 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1406863000408 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1406863000409 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1406863000410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1406863000411 DNA-binding site [nucleotide binding]; DNA binding site 1406863000412 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1406863000413 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1406863000414 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863000415 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1406863000416 intersubunit interface [polypeptide binding]; other site 1406863000417 active site 1406863000418 catalytic residue [active] 1406863000419 phosphopentomutase; Provisional; Region: PRK05362 1406863000420 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1406863000421 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1406863000422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863000423 dimer interface [polypeptide binding]; other site 1406863000424 conserved gate region; other site 1406863000425 putative PBP binding loops; other site 1406863000426 ABC-ATPase subunit interface; other site 1406863000427 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1406863000428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863000429 dimer interface [polypeptide binding]; other site 1406863000430 conserved gate region; other site 1406863000431 ABC-ATPase subunit interface; other site 1406863000432 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1406863000433 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1406863000434 Walker A/P-loop; other site 1406863000435 ATP binding site [chemical binding]; other site 1406863000436 Q-loop/lid; other site 1406863000437 ABC transporter signature motif; other site 1406863000438 Walker B; other site 1406863000439 D-loop; other site 1406863000440 H-loop/switch region; other site 1406863000441 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1406863000442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1406863000443 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1406863000444 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1406863000445 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1406863000446 active site 1406863000447 metal binding site [ion binding]; metal-binding site 1406863000448 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1406863000449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1406863000450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863000451 non-specific DNA binding site [nucleotide binding]; other site 1406863000452 salt bridge; other site 1406863000453 sequence-specific DNA binding site [nucleotide binding]; other site 1406863000454 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1406863000455 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1406863000456 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1406863000457 putative catalytic cysteine [active] 1406863000458 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1406863000459 putative active site [active] 1406863000460 metal binding site [ion binding]; metal-binding site 1406863000461 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1406863000462 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1406863000463 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1406863000464 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1406863000465 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1406863000466 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1406863000467 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1406863000468 NAD(P) binding site [chemical binding]; other site 1406863000469 homodimer interface [polypeptide binding]; other site 1406863000470 substrate binding site [chemical binding]; other site 1406863000471 active site 1406863000472 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1406863000473 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1406863000474 NAD(P) binding site [chemical binding]; other site 1406863000475 homodimer interface [polypeptide binding]; other site 1406863000476 substrate binding site [chemical binding]; other site 1406863000477 active site 1406863000478 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1406863000479 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1406863000480 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1406863000481 putative NAD(P) binding site [chemical binding]; other site 1406863000482 active site 1406863000483 putative substrate binding site [chemical binding]; other site 1406863000484 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1406863000485 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1406863000486 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1406863000487 active site 1406863000488 homodimer interface [polypeptide binding]; other site 1406863000489 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1406863000490 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1406863000491 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1406863000492 trimer interface [polypeptide binding]; other site 1406863000493 active site 1406863000494 substrate binding site [chemical binding]; other site 1406863000495 CoA binding site [chemical binding]; other site 1406863000496 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1406863000497 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1406863000498 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1406863000499 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1406863000500 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1406863000501 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1406863000502 putative NAD(P) binding site [chemical binding]; other site 1406863000503 active site 1406863000504 putative substrate binding site [chemical binding]; other site 1406863000505 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1406863000506 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1406863000507 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1406863000508 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1406863000509 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1406863000510 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1406863000511 active site 1406863000512 homodimer interface [polypeptide binding]; other site 1406863000513 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1406863000514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1406863000515 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1406863000516 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1406863000517 NAD(P) binding site [chemical binding]; other site 1406863000518 catalytic residues [active] 1406863000519 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1406863000520 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1406863000521 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1406863000522 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1406863000523 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1406863000524 Walker A/P-loop; other site 1406863000525 ATP binding site [chemical binding]; other site 1406863000526 Q-loop/lid; other site 1406863000527 ABC transporter signature motif; other site 1406863000528 Walker B; other site 1406863000529 D-loop; other site 1406863000530 H-loop/switch region; other site 1406863000531 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1406863000532 NMT1-like family; Region: NMT1_2; pfam13379 1406863000533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1406863000534 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1406863000535 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1406863000536 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1406863000537 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1406863000538 formate dehydrogenase; Provisional; Region: PRK07574 1406863000539 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1406863000540 dimerization interface [polypeptide binding]; other site 1406863000541 ligand binding site [chemical binding]; other site 1406863000542 NAD binding site [chemical binding]; other site 1406863000543 catalytic site [active] 1406863000544 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1406863000545 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1406863000546 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1406863000547 acyl-activating enzyme (AAE) consensus motif; other site 1406863000548 AMP binding site [chemical binding]; other site 1406863000549 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1406863000550 Condensation domain; Region: Condensation; pfam00668 1406863000551 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1406863000552 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1406863000553 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1406863000554 acyl-activating enzyme (AAE) consensus motif; other site 1406863000555 AMP binding site [chemical binding]; other site 1406863000556 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1406863000557 thioester reductase domain; Region: Thioester-redct; TIGR01746 1406863000558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1406863000559 NAD(P) binding site [chemical binding]; other site 1406863000560 active site 1406863000561 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1406863000562 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1406863000563 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1406863000564 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1406863000565 nucleotide binding site [chemical binding]; other site 1406863000566 N-acetyl-L-glutamate binding site [chemical binding]; other site 1406863000567 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1406863000568 heterotetramer interface [polypeptide binding]; other site 1406863000569 active site pocket [active] 1406863000570 cleavage site 1406863000571 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1406863000572 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1406863000573 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1406863000574 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1406863000575 inhibitor-cofactor binding pocket; inhibition site 1406863000576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863000577 catalytic residue [active] 1406863000578 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1406863000579 Isochorismatase family; Region: Isochorismatase; pfam00857 1406863000580 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1406863000581 catalytic triad [active] 1406863000582 conserved cis-peptide bond; other site 1406863000583 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1406863000584 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1406863000585 dimer interface [polypeptide binding]; other site 1406863000586 PYR/PP interface [polypeptide binding]; other site 1406863000587 TPP binding site [chemical binding]; other site 1406863000588 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1406863000589 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1406863000590 TPP-binding site [chemical binding]; other site 1406863000591 dimer interface [polypeptide binding]; other site 1406863000592 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1406863000593 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1406863000594 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1406863000595 active site turn [active] 1406863000596 phosphorylation site [posttranslational modification] 1406863000597 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1406863000598 HPr interaction site; other site 1406863000599 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1406863000600 active site 1406863000601 phosphorylation site [posttranslational modification] 1406863000602 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1406863000603 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1406863000604 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 1406863000605 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1406863000606 putative active site [active] 1406863000607 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1406863000608 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1406863000609 active site turn [active] 1406863000610 phosphorylation site [posttranslational modification] 1406863000611 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1406863000612 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1406863000613 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1406863000614 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1406863000615 putative active site [active] 1406863000616 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1406863000617 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1406863000618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863000619 ATP binding site [chemical binding]; other site 1406863000620 putative Mg++ binding site [ion binding]; other site 1406863000621 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1406863000622 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863000623 Walker A/P-loop; other site 1406863000624 ATP binding site [chemical binding]; other site 1406863000625 Q-loop/lid; other site 1406863000626 ABC transporter signature motif; other site 1406863000627 Walker B; other site 1406863000628 D-loop; other site 1406863000629 H-loop/switch region; other site 1406863000630 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1406863000631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863000632 Walker A/P-loop; other site 1406863000633 ATP binding site [chemical binding]; other site 1406863000634 Q-loop/lid; other site 1406863000635 ABC transporter signature motif; other site 1406863000636 Walker B; other site 1406863000637 D-loop; other site 1406863000638 H-loop/switch region; other site 1406863000639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1406863000640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863000641 dimer interface [polypeptide binding]; other site 1406863000642 conserved gate region; other site 1406863000643 putative PBP binding loops; other site 1406863000644 ABC-ATPase subunit interface; other site 1406863000645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1406863000646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863000647 dimer interface [polypeptide binding]; other site 1406863000648 conserved gate region; other site 1406863000649 ABC-ATPase subunit interface; other site 1406863000650 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1406863000651 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1406863000652 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1406863000653 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1406863000654 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1406863000655 azoreductase; Reviewed; Region: PRK00170 1406863000656 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1406863000657 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1406863000658 Peptidase family M23; Region: Peptidase_M23; pfam01551 1406863000659 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1406863000660 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1406863000661 Walker A/P-loop; other site 1406863000662 ATP binding site [chemical binding]; other site 1406863000663 Q-loop/lid; other site 1406863000664 ABC transporter signature motif; other site 1406863000665 Walker B; other site 1406863000666 D-loop; other site 1406863000667 H-loop/switch region; other site 1406863000668 TOBE domain; Region: TOBE; pfam03459 1406863000669 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1406863000670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1406863000671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863000672 dimer interface [polypeptide binding]; other site 1406863000673 conserved gate region; other site 1406863000674 ABC-ATPase subunit interface; other site 1406863000675 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1406863000676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863000677 dimer interface [polypeptide binding]; other site 1406863000678 conserved gate region; other site 1406863000679 putative PBP binding loops; other site 1406863000680 ABC-ATPase subunit interface; other site 1406863000681 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1406863000682 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1406863000683 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1406863000684 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1406863000685 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1406863000686 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1406863000687 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1406863000688 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1406863000689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1406863000690 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1406863000691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863000692 putative substrate translocation pore; other site 1406863000693 Response regulator receiver domain; Region: Response_reg; pfam00072 1406863000694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863000695 active site 1406863000696 phosphorylation site [posttranslational modification] 1406863000697 intermolecular recognition site; other site 1406863000698 dimerization interface [polypeptide binding]; other site 1406863000699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1406863000700 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1406863000701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1406863000702 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1406863000703 Histidine kinase; Region: His_kinase; pfam06580 1406863000704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863000705 ATP binding site [chemical binding]; other site 1406863000706 Mg2+ binding site [ion binding]; other site 1406863000707 G-X-G motif; other site 1406863000708 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1406863000709 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1406863000710 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1406863000711 Pyruvate formate lyase 1; Region: PFL1; cd01678 1406863000712 coenzyme A binding site [chemical binding]; other site 1406863000713 active site 1406863000714 catalytic residues [active] 1406863000715 glycine loop; other site 1406863000716 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1406863000717 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863000718 FeS/SAM binding site; other site 1406863000719 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1406863000720 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1406863000721 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1406863000722 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1406863000723 putative active site [active] 1406863000724 catalytic site [active] 1406863000725 putative metal binding site [ion binding]; other site 1406863000726 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1406863000727 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1406863000728 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1406863000729 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1406863000730 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1406863000731 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1406863000732 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1406863000733 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1406863000734 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1406863000735 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1406863000736 dimer interface [polypeptide binding]; other site 1406863000737 active site 1406863000738 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1406863000739 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1406863000740 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1406863000741 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1406863000742 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1406863000743 substrate binding site [chemical binding]; other site 1406863000744 oxyanion hole (OAH) forming residues; other site 1406863000745 trimer interface [polypeptide binding]; other site 1406863000746 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1406863000747 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1406863000748 active site 1406863000749 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1406863000750 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1406863000751 acyl-activating enzyme (AAE) consensus motif; other site 1406863000752 AMP binding site [chemical binding]; other site 1406863000753 active site 1406863000754 CoA binding site [chemical binding]; other site 1406863000755 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1406863000756 Coenzyme A transferase; Region: CoA_trans; smart00882 1406863000757 Coenzyme A transferase; Region: CoA_trans; cl17247 1406863000758 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1406863000759 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1406863000760 catalytic triad [active] 1406863000761 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1406863000762 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1406863000763 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1406863000764 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1406863000765 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1406863000766 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1406863000767 heme-binding site [chemical binding]; other site 1406863000768 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1406863000769 FAD binding pocket [chemical binding]; other site 1406863000770 FAD binding motif [chemical binding]; other site 1406863000771 phosphate binding motif [ion binding]; other site 1406863000772 beta-alpha-beta structure motif; other site 1406863000773 NAD binding pocket [chemical binding]; other site 1406863000774 Heme binding pocket [chemical binding]; other site 1406863000775 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1406863000776 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1406863000777 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1406863000778 NAD binding site [chemical binding]; other site 1406863000779 dimer interface [polypeptide binding]; other site 1406863000780 substrate binding site [chemical binding]; other site 1406863000781 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1406863000782 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1406863000783 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1406863000784 active site turn [active] 1406863000785 phosphorylation site [posttranslational modification] 1406863000786 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1406863000787 active site 1406863000788 tetramer interface [polypeptide binding]; other site 1406863000789 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1406863000790 Mga helix-turn-helix domain; Region: Mga; pfam05043 1406863000791 PRD domain; Region: PRD; pfam00874 1406863000792 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1406863000793 active site 1406863000794 P-loop; other site 1406863000795 phosphorylation site [posttranslational modification] 1406863000796 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1406863000797 active site 1406863000798 phosphorylation site [posttranslational modification] 1406863000799 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1406863000800 active site 1406863000801 phosphorylation site [posttranslational modification] 1406863000802 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1406863000803 active site 1406863000804 P-loop; other site 1406863000805 phosphorylation site [posttranslational modification] 1406863000806 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1406863000807 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1406863000808 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1406863000809 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1406863000810 putative NAD(P) binding site [chemical binding]; other site 1406863000811 catalytic Zn binding site [ion binding]; other site 1406863000812 structural Zn binding site [ion binding]; other site 1406863000813 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1406863000814 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1406863000815 putative NAD(P) binding site [chemical binding]; other site 1406863000816 catalytic Zn binding site [ion binding]; other site 1406863000817 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1406863000818 substrate binding site; other site 1406863000819 dimer interface; other site 1406863000820 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1406863000821 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1406863000822 putative NAD(P) binding site [chemical binding]; other site 1406863000823 putative catalytic Zn binding site [ion binding]; other site 1406863000824 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1406863000825 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1406863000826 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1406863000827 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1406863000828 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1406863000829 substrate binding site; other site 1406863000830 dimer interface; other site 1406863000831 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1406863000832 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1406863000833 putative NAD(P) binding site [chemical binding]; other site 1406863000834 putative catalytic Zn binding site [ion binding]; other site 1406863000835 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1406863000836 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1406863000837 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1406863000838 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1406863000839 active site 1406863000840 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1406863000841 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1406863000842 Hemerythrin-like domain; Region: Hr-like; cd12108 1406863000843 Fe binding site [ion binding]; other site 1406863000844 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1406863000845 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1406863000846 Histidine kinase; Region: His_kinase; pfam06580 1406863000847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863000848 Mg2+ binding site [ion binding]; other site 1406863000849 G-X-G motif; other site 1406863000850 two-component response regulator; Provisional; Region: PRK14084 1406863000851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863000852 active site 1406863000853 phosphorylation site [posttranslational modification] 1406863000854 intermolecular recognition site; other site 1406863000855 dimerization interface [polypeptide binding]; other site 1406863000856 LytTr DNA-binding domain; Region: LytTR; pfam04397 1406863000857 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1406863000858 antiholin-like protein LrgB; Provisional; Region: PRK04288 1406863000859 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1406863000860 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1406863000861 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1406863000862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1406863000863 DNA-binding site [nucleotide binding]; DNA binding site 1406863000864 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1406863000865 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1406863000866 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1406863000867 HPr interaction site; other site 1406863000868 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1406863000869 active site 1406863000870 phosphorylation site [posttranslational modification] 1406863000871 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1406863000872 beta-galactosidase; Region: BGL; TIGR03356 1406863000873 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1406863000874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863000875 S-adenosylmethionine binding site [chemical binding]; other site 1406863000876 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1406863000877 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1406863000878 substrate binding site [chemical binding]; other site 1406863000879 dimer interface [polypeptide binding]; other site 1406863000880 ATP binding site [chemical binding]; other site 1406863000881 D-ribose pyranase; Provisional; Region: PRK11797 1406863000882 Sugar transport protein; Region: Sugar_transport; pfam06800 1406863000883 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1406863000884 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1406863000885 DNA binding site [nucleotide binding] 1406863000886 domain linker motif; other site 1406863000887 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1406863000888 dimerization interface [polypeptide binding]; other site 1406863000889 ligand binding site [chemical binding]; other site 1406863000890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863000891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863000892 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1406863000893 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1406863000894 active site 1406863000895 Surface antigen [General function prediction only]; Region: COG3942 1406863000896 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1406863000897 Peptidase family M23; Region: Peptidase_M23; pfam01551 1406863000898 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1406863000899 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1406863000900 Walker A/P-loop; other site 1406863000901 ATP binding site [chemical binding]; other site 1406863000902 Q-loop/lid; other site 1406863000903 ABC transporter signature motif; other site 1406863000904 Walker B; other site 1406863000905 D-loop; other site 1406863000906 H-loop/switch region; other site 1406863000907 Surface antigen [General function prediction only]; Region: COG3942 1406863000908 CHAP domain; Region: CHAP; pfam05257 1406863000909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1406863000910 Predicted membrane protein [Function unknown]; Region: COG1511 1406863000911 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1406863000912 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1406863000913 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1406863000914 Uncharacterized small protein [Function unknown]; Region: COG5417 1406863000915 Predicted membrane protein [Function unknown]; Region: COG4499 1406863000916 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1406863000917 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1406863000918 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1406863000919 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1406863000920 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1406863000921 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 1406863000922 LXG domain of WXG superfamily; Region: LXG; pfam04740 1406863000923 Protein of unknown function, DUF600; Region: DUF600; cl04640 1406863000924 Protein of unknown function, DUF600; Region: DUF600; cl04640 1406863000925 Protein of unknown function, DUF600; Region: DUF600; cl04640 1406863000926 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1406863000927 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1406863000928 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 1406863000929 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1406863000930 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1406863000931 FtsX-like permease family; Region: FtsX; pfam02687 1406863000932 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1406863000933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1406863000934 Walker A/P-loop; other site 1406863000935 ATP binding site [chemical binding]; other site 1406863000936 Q-loop/lid; other site 1406863000937 ABC transporter signature motif; other site 1406863000938 Walker B; other site 1406863000939 D-loop; other site 1406863000940 H-loop/switch region; other site 1406863000941 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1406863000942 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1406863000943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863000944 non-specific DNA binding site [nucleotide binding]; other site 1406863000945 salt bridge; other site 1406863000946 sequence-specific DNA binding site [nucleotide binding]; other site 1406863000947 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1406863000948 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1406863000949 substrate binding site [chemical binding]; other site 1406863000950 ATP binding site [chemical binding]; other site 1406863000951 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1406863000952 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1406863000953 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1406863000954 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1406863000955 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1406863000956 putative transporter; Provisional; Region: PRK10484 1406863000957 Na binding site [ion binding]; other site 1406863000958 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1406863000959 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1406863000960 inhibitor site; inhibition site 1406863000961 active site 1406863000962 dimer interface [polypeptide binding]; other site 1406863000963 catalytic residue [active] 1406863000964 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1406863000965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1406863000966 nucleotide binding site [chemical binding]; other site 1406863000967 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1406863000968 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1406863000969 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1406863000970 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1406863000971 putative active site [active] 1406863000972 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1406863000973 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1406863000974 putative active site cavity [active] 1406863000975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1406863000976 Nucleoside recognition; Region: Gate; pfam07670 1406863000977 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1406863000978 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1406863000979 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1406863000980 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1406863000981 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1406863000982 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1406863000983 putative active site [active] 1406863000984 putative FMN binding site [chemical binding]; other site 1406863000985 putative substrate binding site [chemical binding]; other site 1406863000986 putative catalytic residue [active] 1406863000987 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1406863000988 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1406863000989 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1406863000990 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1406863000991 lipoyl attachment site [posttranslational modification]; other site 1406863000992 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1406863000993 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1406863000994 putative ADP-ribose binding site [chemical binding]; other site 1406863000995 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1406863000996 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1406863000997 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1406863000998 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1406863000999 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1406863001000 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1406863001001 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1406863001002 NADP binding site [chemical binding]; other site 1406863001003 putative substrate binding site [chemical binding]; other site 1406863001004 active site 1406863001005 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1406863001006 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1406863001007 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1406863001008 active site 1406863001009 phosphorylation site [posttranslational modification] 1406863001010 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1406863001011 HTH domain; Region: HTH_11; pfam08279 1406863001012 HTH domain; Region: HTH_11; pfam08279 1406863001013 PRD domain; Region: PRD; pfam00874 1406863001014 PRD domain; Region: PRD; pfam00874 1406863001015 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1406863001016 active site 1406863001017 P-loop; other site 1406863001018 phosphorylation site [posttranslational modification] 1406863001019 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1406863001020 active site 1406863001021 phosphorylation site [posttranslational modification] 1406863001022 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1406863001023 MarR family; Region: MarR_2; pfam12802 1406863001024 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1406863001025 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1406863001026 MepB protein; Region: MepB; cl01985 1406863001027 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1406863001028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863001029 putative substrate translocation pore; other site 1406863001030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863001031 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1406863001032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1406863001033 Zn binding site [ion binding]; other site 1406863001034 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1406863001035 Zn binding site [ion binding]; other site 1406863001036 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1406863001037 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1406863001038 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1406863001039 Predicted flavoprotein [General function prediction only]; Region: COG0431 1406863001040 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1406863001041 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1406863001042 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1406863001043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1406863001044 Imelysin; Region: Peptidase_M75; pfam09375 1406863001045 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1406863001046 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1406863001047 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1406863001048 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1406863001049 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1406863001050 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1406863001051 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1406863001052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863001053 non-specific DNA binding site [nucleotide binding]; other site 1406863001054 salt bridge; other site 1406863001055 sequence-specific DNA binding site [nucleotide binding]; other site 1406863001056 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1406863001057 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1406863001058 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1406863001059 Walker A/P-loop; other site 1406863001060 ATP binding site [chemical binding]; other site 1406863001061 Q-loop/lid; other site 1406863001062 ABC transporter signature motif; other site 1406863001063 Walker B; other site 1406863001064 D-loop; other site 1406863001065 H-loop/switch region; other site 1406863001066 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1406863001067 Predicted membrane protein [Function unknown]; Region: COG4292 1406863001068 putative acyltransferase; Provisional; Region: PRK05790 1406863001069 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1406863001070 dimer interface [polypeptide binding]; other site 1406863001071 active site 1406863001072 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1406863001073 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1406863001074 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1406863001075 THF binding site; other site 1406863001076 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1406863001077 substrate binding site [chemical binding]; other site 1406863001078 THF binding site; other site 1406863001079 zinc-binding site [ion binding]; other site 1406863001080 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1406863001081 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1406863001082 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1406863001083 FAD binding site [chemical binding]; other site 1406863001084 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1406863001085 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1406863001086 homodimer interface [polypeptide binding]; other site 1406863001087 substrate-cofactor binding pocket; other site 1406863001088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863001089 catalytic residue [active] 1406863001090 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1406863001091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1406863001092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1406863001093 catalytic residue [active] 1406863001094 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1406863001095 ParB-like nuclease domain; Region: ParB; smart00470 1406863001096 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1406863001097 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1406863001098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 1406863001099 GTP-binding protein YchF; Reviewed; Region: PRK09601 1406863001100 YchF GTPase; Region: YchF; cd01900 1406863001101 G1 box; other site 1406863001102 GTP/Mg2+ binding site [chemical binding]; other site 1406863001103 Switch I region; other site 1406863001104 G2 box; other site 1406863001105 Switch II region; other site 1406863001106 G3 box; other site 1406863001107 G4 box; other site 1406863001108 G5 box; other site 1406863001109 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1406863001110 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1406863001111 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1406863001112 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1406863001113 dimer interface [polypeptide binding]; other site 1406863001114 ssDNA binding site [nucleotide binding]; other site 1406863001115 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1406863001116 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1406863001117 Abi-like protein; Region: Abi_2; pfam07751 1406863001118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1406863001119 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1406863001120 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1406863001122 Predicted membrane protein [Function unknown]; Region: COG3212 1406863001123 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1406863001124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1406863001125 non-specific DNA binding site [nucleotide binding]; other site 1406863001126 salt bridge; other site 1406863001127 sequence-specific DNA binding site [nucleotide binding]; other site 1406863001128 Predicted membrane protein [Function unknown]; Region: COG2261 1406863001129 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1406863001130 catalytic core [active] 1406863001131 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1406863001132 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1406863001133 catalytic residue [active] 1406863001134 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1406863001135 catalytic residues [active] 1406863001136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1406863001137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863001138 peroxiredoxin; Region: AhpC; TIGR03137 1406863001139 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1406863001140 dimer interface [polypeptide binding]; other site 1406863001141 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1406863001142 catalytic triad [active] 1406863001143 peroxidatic and resolving cysteines [active] 1406863001144 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1406863001145 dimer interface [polypeptide binding]; other site 1406863001146 FMN binding site [chemical binding]; other site 1406863001147 NADPH bind site [chemical binding]; other site 1406863001148 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1406863001149 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1406863001150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1406863001151 active site 1406863001152 xanthine permease; Region: pbuX; TIGR03173 1406863001153 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1406863001154 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1406863001155 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1406863001156 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1406863001157 active site 1406863001158 GMP synthase; Reviewed; Region: guaA; PRK00074 1406863001159 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1406863001160 AMP/PPi binding site [chemical binding]; other site 1406863001161 candidate oxyanion hole; other site 1406863001162 catalytic triad [active] 1406863001163 potential glutamine specificity residues [chemical binding]; other site 1406863001164 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1406863001165 ATP Binding subdomain [chemical binding]; other site 1406863001166 Ligand Binding sites [chemical binding]; other site 1406863001167 Dimerization subdomain; other site 1406863001168 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1406863001169 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1406863001170 Int/Topo IB signature motif; other site 1406863001171 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 1406863001172 Helix-turn-helix domain; Region: HTH_16; pfam12645 1406863001173 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1406863001174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1406863001175 DNA binding residues [nucleotide binding] 1406863001176 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1406863001177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863001178 non-specific DNA binding site [nucleotide binding]; other site 1406863001179 salt bridge; other site 1406863001180 sequence-specific DNA binding site [nucleotide binding]; other site 1406863001181 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1406863001182 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1406863001183 G1 box; other site 1406863001184 putative GEF interaction site [polypeptide binding]; other site 1406863001185 GTP/Mg2+ binding site [chemical binding]; other site 1406863001186 Switch I region; other site 1406863001187 G2 box; other site 1406863001188 G3 box; other site 1406863001189 Switch II region; other site 1406863001190 G4 box; other site 1406863001191 G5 box; other site 1406863001192 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1406863001193 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1406863001194 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1406863001195 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1406863001196 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1406863001197 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1406863001198 catalytic residue [active] 1406863001199 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1406863001200 NlpC/P60 family; Region: NLPC_P60; pfam00877 1406863001201 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1406863001202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863001203 AAA-like domain; Region: AAA_10; pfam12846 1406863001204 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1406863001205 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1406863001206 folate binding site [chemical binding]; other site 1406863001207 NADP+ binding site [chemical binding]; other site 1406863001208 transposase/IS protein; Provisional; Region: PRK09183 1406863001209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863001210 Walker A motif; other site 1406863001211 ATP binding site [chemical binding]; other site 1406863001212 Walker B motif; other site 1406863001213 arginine finger; other site 1406863001214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1406863001215 Integrase core domain; Region: rve; pfam00665 1406863001216 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1406863001217 Abortive infection C-terminus; Region: Abi_C; pfam14355 1406863001218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863001219 non-specific DNA binding site [nucleotide binding]; other site 1406863001220 salt bridge; other site 1406863001221 sequence-specific DNA binding site [nucleotide binding]; other site 1406863001222 Replication initiation factor; Region: Rep_trans; pfam02486 1406863001223 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1406863001224 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1406863001225 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1406863001226 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1406863001227 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1406863001228 Part of AAA domain; Region: AAA_19; pfam13245 1406863001229 Family description; Region: UvrD_C_2; pfam13538 1406863001230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863001231 AAA domain; Region: AAA_21; pfam13304 1406863001232 Walker A/P-loop; other site 1406863001233 ATP binding site [chemical binding]; other site 1406863001234 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1406863001235 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1406863001236 putative active site [active] 1406863001237 putative metal-binding site [ion binding]; other site 1406863001238 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863001239 MULE transposase domain; Region: MULE; pfam10551 1406863001240 PemK-like protein; Region: PemK; pfam02452 1406863001241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1406863001242 Transposase; Region: HTH_Tnp_1; cl17663 1406863001243 Predicted membrane protein [Function unknown]; Region: COG3759 1406863001244 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1406863001245 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1406863001246 NADP binding site [chemical binding]; other site 1406863001247 superantigen-like protein; Reviewed; Region: PRK13037 1406863001248 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001249 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001250 superantigen-like protein; Reviewed; Region: PRK13041 1406863001251 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001252 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001253 superantigen-like protein; Reviewed; Region: PRK13335 1406863001254 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001255 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001256 superantigen-like protein; Reviewed; Region: PRK13042 1406863001257 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001258 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001259 superantigen-like protein 5; Reviewed; Region: PRK13035 1406863001260 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001261 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001262 superantigen-like protein; Reviewed; Region: PRK13040 1406863001263 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001264 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001265 superantigen-like protein 7; Reviewed; Region: PRK13346 1406863001266 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001267 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001268 superantigen-like protein; Reviewed; Region: PRK13039 1406863001269 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001270 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001271 superantigen-like protein; Reviewed; Region: PRK13345 1406863001272 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001273 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001274 superantigen-like protein 5; Reviewed; Region: PRK13035 1406863001275 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001276 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001277 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1406863001278 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1406863001279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863001280 S-adenosylmethionine binding site [chemical binding]; other site 1406863001281 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1406863001282 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1406863001283 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1406863001284 superantigen-like protein; Reviewed; Region: PRK13036 1406863001285 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1406863001286 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863001287 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1406863001288 Protein of unknown function, DUF576; Region: DUF576; cl04553 1406863001289 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1406863001290 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1406863001291 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1406863001292 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1406863001293 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1406863001294 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1406863001295 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1406863001296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1406863001297 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1406863001298 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1406863001299 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1406863001300 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1406863001301 active site 1406863001302 Esterase/lipase [General function prediction only]; Region: COG1647 1406863001303 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1406863001304 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1406863001305 Na2 binding site [ion binding]; other site 1406863001306 putative substrate binding site 1 [chemical binding]; other site 1406863001307 Na binding site 1 [ion binding]; other site 1406863001308 putative substrate binding site 2 [chemical binding]; other site 1406863001309 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1406863001310 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1406863001311 dimer interface [polypeptide binding]; other site 1406863001312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863001313 catalytic residue [active] 1406863001314 cystathionine beta-lyase; Provisional; Region: PRK07671 1406863001315 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1406863001316 homodimer interface [polypeptide binding]; other site 1406863001317 substrate-cofactor binding pocket; other site 1406863001318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863001319 catalytic residue [active] 1406863001320 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1406863001321 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1406863001322 Walker A/P-loop; other site 1406863001323 ATP binding site [chemical binding]; other site 1406863001324 Q-loop/lid; other site 1406863001325 ABC transporter signature motif; other site 1406863001326 Walker B; other site 1406863001327 D-loop; other site 1406863001328 H-loop/switch region; other site 1406863001329 NIL domain; Region: NIL; pfam09383 1406863001330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863001331 dimer interface [polypeptide binding]; other site 1406863001332 conserved gate region; other site 1406863001333 ABC-ATPase subunit interface; other site 1406863001334 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1406863001335 LysM domain; Region: LysM; pfam01476 1406863001336 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1406863001337 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1406863001338 Surface antigen [General function prediction only]; Region: COG3942 1406863001339 CHAP domain; Region: CHAP; pfam05257 1406863001340 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1406863001341 nudix motif; other site 1406863001342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863001343 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1406863001344 Coenzyme A binding pocket [chemical binding]; other site 1406863001345 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1406863001346 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1406863001347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1406863001348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1406863001349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1406863001350 dimerization interface [polypeptide binding]; other site 1406863001351 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1406863001352 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1406863001353 active site 1406863001354 dimer interface [polypeptide binding]; other site 1406863001355 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1406863001356 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1406863001357 active site 1406863001358 FMN binding site [chemical binding]; other site 1406863001359 substrate binding site [chemical binding]; other site 1406863001360 3Fe-4S cluster binding site [ion binding]; other site 1406863001361 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1406863001362 domain interface; other site 1406863001363 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1406863001364 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1406863001365 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1406863001366 active site turn [active] 1406863001367 phosphorylation site [posttranslational modification] 1406863001368 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1406863001369 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1406863001370 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1406863001371 Ca binding site [ion binding]; other site 1406863001372 active site 1406863001373 catalytic site [active] 1406863001374 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1406863001375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1406863001376 DNA-binding site [nucleotide binding]; DNA binding site 1406863001377 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1406863001378 UTRA domain; Region: UTRA; pfam07702 1406863001379 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1406863001380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863001381 Coenzyme A binding pocket [chemical binding]; other site 1406863001382 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1406863001383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863001384 Walker A motif; other site 1406863001385 ATP binding site [chemical binding]; other site 1406863001386 Walker B motif; other site 1406863001387 arginine finger; other site 1406863001388 hypothetical protein; Validated; Region: PRK00153 1406863001389 recombination protein RecR; Reviewed; Region: recR; PRK00076 1406863001390 RecR protein; Region: RecR; pfam02132 1406863001391 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1406863001392 putative active site [active] 1406863001393 putative metal-binding site [ion binding]; other site 1406863001394 tetramer interface [polypeptide binding]; other site 1406863001395 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1406863001396 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1406863001397 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1406863001398 catalytic residue [active] 1406863001399 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1406863001400 thymidylate kinase; Validated; Region: tmk; PRK00698 1406863001401 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1406863001402 TMP-binding site; other site 1406863001403 ATP-binding site [chemical binding]; other site 1406863001404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1406863001405 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1406863001406 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1406863001407 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1406863001408 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1406863001409 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1406863001410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863001411 S-adenosylmethionine binding site [chemical binding]; other site 1406863001412 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1406863001413 GIY-YIG motif/motif A; other site 1406863001414 putative active site [active] 1406863001415 putative metal binding site [ion binding]; other site 1406863001416 Predicted methyltransferases [General function prediction only]; Region: COG0313 1406863001417 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1406863001418 putative SAM binding site [chemical binding]; other site 1406863001419 putative homodimer interface [polypeptide binding]; other site 1406863001420 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1406863001421 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1406863001422 active site 1406863001423 HIGH motif; other site 1406863001424 KMSKS motif; other site 1406863001425 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1406863001426 tRNA binding surface [nucleotide binding]; other site 1406863001427 anticodon binding site; other site 1406863001428 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1406863001429 dimer interface [polypeptide binding]; other site 1406863001430 putative tRNA-binding site [nucleotide binding]; other site 1406863001431 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1406863001432 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1406863001433 active site 1406863001434 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1406863001435 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1406863001436 putative active site [active] 1406863001437 putative metal binding site [ion binding]; other site 1406863001438 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1406863001439 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1406863001440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863001441 S-adenosylmethionine binding site [chemical binding]; other site 1406863001442 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1406863001443 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1406863001444 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1406863001445 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1406863001446 pur operon repressor; Provisional; Region: PRK09213 1406863001447 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1406863001448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1406863001449 active site 1406863001450 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1406863001451 homotrimer interaction site [polypeptide binding]; other site 1406863001452 putative active site [active] 1406863001453 regulatory protein SpoVG; Reviewed; Region: PRK13259 1406863001454 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1406863001455 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1406863001456 Substrate binding site; other site 1406863001457 Mg++ binding site; other site 1406863001458 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1406863001459 active site 1406863001460 substrate binding site [chemical binding]; other site 1406863001461 CoA binding site [chemical binding]; other site 1406863001462 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1406863001463 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1406863001464 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1406863001465 active site 1406863001466 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1406863001467 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1406863001468 5S rRNA interface [nucleotide binding]; other site 1406863001469 CTC domain interface [polypeptide binding]; other site 1406863001470 L16 interface [polypeptide binding]; other site 1406863001471 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1406863001472 putative active site [active] 1406863001473 catalytic residue [active] 1406863001474 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1406863001475 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1406863001476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863001477 ATP binding site [chemical binding]; other site 1406863001478 putative Mg++ binding site [ion binding]; other site 1406863001479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1406863001480 nucleotide binding region [chemical binding]; other site 1406863001481 ATP-binding site [chemical binding]; other site 1406863001482 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1406863001483 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1406863001484 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1406863001485 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1406863001486 putative SAM binding site [chemical binding]; other site 1406863001487 putative homodimer interface [polypeptide binding]; other site 1406863001488 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1406863001489 homodimer interface [polypeptide binding]; other site 1406863001490 metal binding site [ion binding]; metal-binding site 1406863001491 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1406863001492 RNA binding surface [nucleotide binding]; other site 1406863001493 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1406863001494 Septum formation initiator; Region: DivIC; pfam04977 1406863001495 hypothetical protein; Provisional; Region: PRK08582 1406863001496 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1406863001497 RNA binding site [nucleotide binding]; other site 1406863001498 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1406863001499 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1406863001500 Ligand Binding Site [chemical binding]; other site 1406863001501 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1406863001502 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1406863001503 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1406863001504 active site 1406863001505 FtsH Extracellular; Region: FtsH_ext; pfam06480 1406863001506 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1406863001507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863001508 Walker A motif; other site 1406863001509 ATP binding site [chemical binding]; other site 1406863001510 Walker B motif; other site 1406863001511 arginine finger; other site 1406863001512 Peptidase family M41; Region: Peptidase_M41; pfam01434 1406863001513 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1406863001514 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1406863001515 dimerization interface [polypeptide binding]; other site 1406863001516 domain crossover interface; other site 1406863001517 redox-dependent activation switch; other site 1406863001518 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1406863001519 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1406863001520 dimer interface [polypeptide binding]; other site 1406863001521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863001522 catalytic residue [active] 1406863001523 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1406863001524 dihydropteroate synthase; Region: DHPS; TIGR01496 1406863001525 substrate binding pocket [chemical binding]; other site 1406863001526 dimer interface [polypeptide binding]; other site 1406863001527 inhibitor binding site; inhibition site 1406863001528 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1406863001529 homooctamer interface [polypeptide binding]; other site 1406863001530 active site 1406863001531 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1406863001532 catalytic center binding site [active] 1406863001533 ATP binding site [chemical binding]; other site 1406863001534 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1406863001535 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1406863001536 dimer interface [polypeptide binding]; other site 1406863001537 putative anticodon binding site; other site 1406863001538 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1406863001539 motif 1; other site 1406863001540 active site 1406863001541 motif 2; other site 1406863001542 motif 3; other site 1406863001543 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1406863001544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1406863001545 DNA-binding site [nucleotide binding]; DNA binding site 1406863001546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1406863001547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863001548 homodimer interface [polypeptide binding]; other site 1406863001549 catalytic residue [active] 1406863001550 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1406863001551 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1406863001552 active site 1406863001553 multimer interface [polypeptide binding]; other site 1406863001554 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1406863001555 predicted active site [active] 1406863001556 catalytic triad [active] 1406863001557 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1406863001558 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1406863001559 Nucleoside recognition; Region: Gate; pfam07670 1406863001560 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1406863001561 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1406863001562 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1406863001563 UvrB/uvrC motif; Region: UVR; pfam02151 1406863001564 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1406863001565 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1406863001566 ADP binding site [chemical binding]; other site 1406863001567 phosphagen binding site; other site 1406863001568 substrate specificity loop; other site 1406863001569 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1406863001570 Clp amino terminal domain; Region: Clp_N; pfam02861 1406863001571 Clp amino terminal domain; Region: Clp_N; pfam02861 1406863001572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863001573 Walker A motif; other site 1406863001574 ATP binding site [chemical binding]; other site 1406863001575 Walker B motif; other site 1406863001576 arginine finger; other site 1406863001577 UvrB/uvrC motif; Region: UVR; pfam02151 1406863001578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863001579 Walker A motif; other site 1406863001580 ATP binding site [chemical binding]; other site 1406863001581 Walker B motif; other site 1406863001582 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1406863001583 DNA repair protein RadA; Provisional; Region: PRK11823 1406863001584 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1406863001585 Walker A motif/ATP binding site; other site 1406863001586 ATP binding site [chemical binding]; other site 1406863001587 Walker B motif; other site 1406863001588 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1406863001589 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1406863001590 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1406863001591 putative active site [active] 1406863001592 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1406863001593 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1406863001594 active site 1406863001595 HIGH motif; other site 1406863001596 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1406863001597 active site 1406863001598 KMSKS motif; other site 1406863001599 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1406863001600 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1406863001601 trimer interface [polypeptide binding]; other site 1406863001602 active site 1406863001603 substrate binding site [chemical binding]; other site 1406863001604 CoA binding site [chemical binding]; other site 1406863001605 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1406863001606 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1406863001607 active site 1406863001608 HIGH motif; other site 1406863001609 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1406863001610 KMSKS motif; other site 1406863001611 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1406863001612 tRNA binding surface [nucleotide binding]; other site 1406863001613 anticodon binding site; other site 1406863001614 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1406863001615 active site 1406863001616 dimerization interface [polypeptide binding]; other site 1406863001617 metal binding site [ion binding]; metal-binding site 1406863001618 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1406863001619 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1406863001620 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1406863001621 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1406863001622 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1406863001623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1406863001624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1406863001625 DNA binding residues [nucleotide binding] 1406863001626 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1406863001627 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1406863001628 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1406863001629 putative homodimer interface [polypeptide binding]; other site 1406863001630 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1406863001631 heterodimer interface [polypeptide binding]; other site 1406863001632 homodimer interface [polypeptide binding]; other site 1406863001633 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1406863001634 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1406863001635 23S rRNA interface [nucleotide binding]; other site 1406863001636 L7/L12 interface [polypeptide binding]; other site 1406863001637 putative thiostrepton binding site; other site 1406863001638 L25 interface [polypeptide binding]; other site 1406863001639 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1406863001640 mRNA/rRNA interface [nucleotide binding]; other site 1406863001641 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1406863001642 23S rRNA interface [nucleotide binding]; other site 1406863001643 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1406863001644 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1406863001645 peripheral dimer interface [polypeptide binding]; other site 1406863001646 core dimer interface [polypeptide binding]; other site 1406863001647 L10 interface [polypeptide binding]; other site 1406863001648 L11 interface [polypeptide binding]; other site 1406863001649 putative EF-Tu interaction site [polypeptide binding]; other site 1406863001650 putative EF-G interaction site [polypeptide binding]; other site 1406863001651 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1406863001652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863001653 S-adenosylmethionine binding site [chemical binding]; other site 1406863001654 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1406863001655 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1406863001656 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1406863001657 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1406863001658 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1406863001659 RPB10 interaction site [polypeptide binding]; other site 1406863001660 RPB1 interaction site [polypeptide binding]; other site 1406863001661 RPB11 interaction site [polypeptide binding]; other site 1406863001662 RPB3 interaction site [polypeptide binding]; other site 1406863001663 RPB12 interaction site [polypeptide binding]; other site 1406863001664 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1406863001665 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1406863001666 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1406863001667 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1406863001668 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1406863001669 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1406863001670 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1406863001671 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1406863001672 G-loop; other site 1406863001673 DNA binding site [nucleotide binding] 1406863001674 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1406863001675 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1406863001676 S17 interaction site [polypeptide binding]; other site 1406863001677 S8 interaction site; other site 1406863001678 16S rRNA interaction site [nucleotide binding]; other site 1406863001679 streptomycin interaction site [chemical binding]; other site 1406863001680 23S rRNA interaction site [nucleotide binding]; other site 1406863001681 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1406863001682 30S ribosomal protein S7; Validated; Region: PRK05302 1406863001683 elongation factor G; Reviewed; Region: PRK00007 1406863001684 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1406863001685 G1 box; other site 1406863001686 putative GEF interaction site [polypeptide binding]; other site 1406863001687 GTP/Mg2+ binding site [chemical binding]; other site 1406863001688 Switch I region; other site 1406863001689 G2 box; other site 1406863001690 G3 box; other site 1406863001691 Switch II region; other site 1406863001692 G4 box; other site 1406863001693 G5 box; other site 1406863001694 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1406863001695 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1406863001696 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1406863001697 elongation factor Tu; Reviewed; Region: PRK00049 1406863001698 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1406863001699 G1 box; other site 1406863001700 GEF interaction site [polypeptide binding]; other site 1406863001701 GTP/Mg2+ binding site [chemical binding]; other site 1406863001702 Switch I region; other site 1406863001703 G2 box; other site 1406863001704 G3 box; other site 1406863001705 Switch II region; other site 1406863001706 G4 box; other site 1406863001707 G5 box; other site 1406863001708 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1406863001709 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1406863001710 Antibiotic Binding Site [chemical binding]; other site 1406863001711 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1406863001712 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1406863001713 metal binding site [ion binding]; metal-binding site 1406863001714 dimer interface [polypeptide binding]; other site 1406863001715 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1406863001716 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1406863001717 substrate-cofactor binding pocket; other site 1406863001718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863001719 catalytic residue [active] 1406863001720 chaperone protein HchA; Provisional; Region: PRK04155 1406863001721 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1406863001722 dimer interface [polypeptide binding]; other site 1406863001723 metal binding site [ion binding]; metal-binding site 1406863001724 potential oxyanion hole; other site 1406863001725 potential catalytic triad [active] 1406863001726 conserved cys residue [active] 1406863001727 ribulokinase; Provisional; Region: PRK04123 1406863001728 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1406863001729 N- and C-terminal domain interface [polypeptide binding]; other site 1406863001730 active site 1406863001731 MgATP binding site [chemical binding]; other site 1406863001732 catalytic site [active] 1406863001733 metal binding site [ion binding]; metal-binding site 1406863001734 carbohydrate binding site [chemical binding]; other site 1406863001735 homodimer interface [polypeptide binding]; other site 1406863001736 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1406863001737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1406863001738 NAD(P) binding site [chemical binding]; other site 1406863001739 active site 1406863001740 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1406863001741 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1406863001742 homodimer interface [polypeptide binding]; other site 1406863001743 substrate-cofactor binding pocket; other site 1406863001744 catalytic residue [active] 1406863001745 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1406863001746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863001747 motif II; other site 1406863001748 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1406863001749 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1406863001750 Substrate-binding site [chemical binding]; other site 1406863001751 Substrate specificity [chemical binding]; other site 1406863001752 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1406863001753 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1406863001754 Substrate-binding site [chemical binding]; other site 1406863001755 Substrate specificity [chemical binding]; other site 1406863001756 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1406863001757 nucleoside/Zn binding site; other site 1406863001758 dimer interface [polypeptide binding]; other site 1406863001759 catalytic motif [active] 1406863001760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863001761 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1406863001762 active site 1406863001763 motif I; other site 1406863001764 motif II; other site 1406863001765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863001766 Predicted flavoprotein [General function prediction only]; Region: COG0431 1406863001767 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1406863001768 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863001769 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1406863001770 Cna protein B-type domain; Region: Cna_B; pfam05738 1406863001771 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1406863001772 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863001773 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1406863001774 Cna protein B-type domain; Region: Cna_B; pfam05738 1406863001775 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1406863001776 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1406863001777 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1406863001778 Cna protein B-type domain; Region: Cna_B; pfam05738 1406863001779 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1406863001780 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1406863001781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1406863001782 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1406863001783 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1406863001784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1406863001785 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1406863001786 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1406863001787 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1406863001788 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1406863001789 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1406863001790 active site 1406863001791 trimer interface [polypeptide binding]; other site 1406863001792 allosteric site; other site 1406863001793 active site lid [active] 1406863001794 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1406863001795 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1406863001796 active site 1406863001797 dimer interface [polypeptide binding]; other site 1406863001798 magnesium binding site [ion binding]; other site 1406863001799 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1406863001800 tetramer interface [polypeptide binding]; other site 1406863001801 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1406863001802 active site 1406863001803 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1406863001804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863001805 motif II; other site 1406863001806 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863001807 MULE transposase domain; Region: MULE; pfam10551 1406863001808 proline/glycine betaine transporter; Provisional; Region: PRK10642 1406863001809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863001810 putative substrate translocation pore; other site 1406863001811 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1406863001812 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1406863001813 acyl-activating enzyme (AAE) consensus motif; other site 1406863001814 AMP binding site [chemical binding]; other site 1406863001815 active site 1406863001816 CoA binding site [chemical binding]; other site 1406863001817 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1406863001818 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1406863001819 dimer interface [polypeptide binding]; other site 1406863001820 active site 1406863001821 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1406863001822 dimer interface [polypeptide binding]; other site 1406863001823 substrate binding site [chemical binding]; other site 1406863001824 ATP binding site [chemical binding]; other site 1406863001825 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1406863001826 ligand binding site [chemical binding]; other site 1406863001827 active site 1406863001828 UGI interface [polypeptide binding]; other site 1406863001829 catalytic site [active] 1406863001830 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1406863001831 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1406863001832 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1406863001833 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1406863001834 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1406863001835 putative heme peroxidase; Provisional; Region: PRK12276 1406863001836 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1406863001837 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1406863001838 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863001839 MULE transposase domain; Region: MULE; pfam10551 1406863001840 mevalonate kinase; Region: mevalon_kin; TIGR00549 1406863001841 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1406863001842 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1406863001843 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1406863001844 diphosphomevalonate decarboxylase; Region: PLN02407 1406863001845 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1406863001846 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1406863001847 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1406863001848 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1406863001849 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1406863001850 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1406863001851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863001852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1406863001853 Predicted transcriptional regulator [Transcription]; Region: COG1959 1406863001854 Transcriptional regulator; Region: Rrf2; pfam02082 1406863001855 LXG domain of WXG superfamily; Region: LXG; pfam04740 1406863001856 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001857 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001858 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001859 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001860 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001861 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001862 Protein of unknown function (DUF443); Region: DUF443; cl04467 1406863001863 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001864 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001865 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001866 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001867 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1406863001868 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1406863001869 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1406863001870 active site 1406863001871 catalytic tetrad [active] 1406863001872 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1406863001873 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1406863001874 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1406863001875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863001876 Coenzyme A binding pocket [chemical binding]; other site 1406863001877 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1406863001878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1406863001879 Zn2+ binding site [ion binding]; other site 1406863001880 Mg2+ binding site [ion binding]; other site 1406863001881 YwhD family; Region: YwhD; pfam08741 1406863001882 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1406863001883 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1406863001884 NAD binding site [chemical binding]; other site 1406863001885 substrate binding site [chemical binding]; other site 1406863001886 catalytic Zn binding site [ion binding]; other site 1406863001887 tetramer interface [polypeptide binding]; other site 1406863001888 structural Zn binding site [ion binding]; other site 1406863001889 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1406863001890 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1406863001891 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1406863001892 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1406863001893 active site 1406863001894 HIGH motif; other site 1406863001895 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1406863001896 KMSK motif region; other site 1406863001897 tRNA binding surface [nucleotide binding]; other site 1406863001898 DALR anticodon binding domain; Region: DALR_1; smart00836 1406863001899 anticodon binding site; other site 1406863001900 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1406863001901 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1406863001902 minor groove reading motif; other site 1406863001903 helix-hairpin-helix signature motif; other site 1406863001904 substrate binding pocket [chemical binding]; other site 1406863001905 active site 1406863001906 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1406863001907 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1406863001908 putative binding site residues; other site 1406863001909 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1406863001910 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863001911 ABC-ATPase subunit interface; other site 1406863001912 dimer interface [polypeptide binding]; other site 1406863001913 putative PBP binding regions; other site 1406863001914 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1406863001915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863001916 motif II; other site 1406863001917 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1406863001918 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1406863001919 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1406863001920 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1406863001921 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863001922 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1406863001923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1406863001924 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1406863001925 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1406863001926 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1406863001927 active site 1406863001928 DNA binding site [nucleotide binding] 1406863001929 Int/Topo IB signature motif; other site 1406863001930 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1406863001931 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1406863001932 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1406863001933 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1406863001934 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1406863001935 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1406863001936 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1406863001937 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1406863001938 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1406863001939 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1406863001940 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1406863001941 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1406863001942 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1406863001943 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1406863001944 metal binding site [ion binding]; metal-binding site 1406863001945 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1406863001946 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863001947 ABC-ATPase subunit interface; other site 1406863001948 dimer interface [polypeptide binding]; other site 1406863001949 putative PBP binding regions; other site 1406863001950 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1406863001951 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1406863001952 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1406863001953 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1406863001954 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1406863001955 FeoA domain; Region: FeoA; pfam04023 1406863001956 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1406863001957 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1406863001958 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1406863001959 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1406863001960 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1406863001961 Walker A/P-loop; other site 1406863001962 ATP binding site [chemical binding]; other site 1406863001963 Q-loop/lid; other site 1406863001964 ABC transporter signature motif; other site 1406863001965 Walker B; other site 1406863001966 D-loop; other site 1406863001967 H-loop/switch region; other site 1406863001968 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1406863001969 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1406863001970 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1406863001971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1406863001972 active site 1406863001973 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1406863001974 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1406863001975 active site 1406863001976 nucleotide binding site [chemical binding]; other site 1406863001977 HIGH motif; other site 1406863001978 KMSKS motif; other site 1406863001979 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1406863001980 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1406863001981 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1406863001982 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1406863001983 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1406863001984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863001985 Walker A/P-loop; other site 1406863001986 ATP binding site [chemical binding]; other site 1406863001987 Q-loop/lid; other site 1406863001988 ABC transporter signature motif; other site 1406863001989 Walker B; other site 1406863001990 D-loop; other site 1406863001991 H-loop/switch region; other site 1406863001992 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1406863001993 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1406863001994 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1406863001995 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1406863001996 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1406863001997 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1406863001998 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1406863001999 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1406863002000 Walker A/P-loop; other site 1406863002001 ATP binding site [chemical binding]; other site 1406863002002 Q-loop/lid; other site 1406863002003 ABC transporter signature motif; other site 1406863002004 Walker B; other site 1406863002005 D-loop; other site 1406863002006 H-loop/switch region; other site 1406863002007 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1406863002008 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863002009 ABC-ATPase subunit interface; other site 1406863002010 dimer interface [polypeptide binding]; other site 1406863002011 putative PBP binding regions; other site 1406863002012 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1406863002013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863002014 ABC-ATPase subunit interface; other site 1406863002015 dimer interface [polypeptide binding]; other site 1406863002016 putative PBP binding regions; other site 1406863002017 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1406863002018 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1406863002019 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1406863002020 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1406863002021 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1406863002022 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1406863002023 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1406863002024 Na binding site [ion binding]; other site 1406863002025 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1406863002026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1406863002027 substrate binding pocket [chemical binding]; other site 1406863002028 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1406863002029 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1406863002030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863002031 Coenzyme A binding pocket [chemical binding]; other site 1406863002032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1406863002033 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1406863002034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1406863002035 NAD(P) binding site [chemical binding]; other site 1406863002036 active site 1406863002037 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1406863002038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863002039 active site 1406863002040 phosphorylation site [posttranslational modification] 1406863002041 intermolecular recognition site; other site 1406863002042 dimerization interface [polypeptide binding]; other site 1406863002043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1406863002044 DNA binding site [nucleotide binding] 1406863002045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1406863002046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1406863002047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863002048 ATP binding site [chemical binding]; other site 1406863002049 Mg2+ binding site [ion binding]; other site 1406863002050 G-X-G motif; other site 1406863002051 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1406863002052 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1406863002053 Walker A/P-loop; other site 1406863002054 ATP binding site [chemical binding]; other site 1406863002055 Q-loop/lid; other site 1406863002056 ABC transporter signature motif; other site 1406863002057 Walker B; other site 1406863002058 D-loop; other site 1406863002059 H-loop/switch region; other site 1406863002060 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1406863002061 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1406863002062 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1406863002063 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1406863002064 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1406863002065 Surface antigen [General function prediction only]; Region: COG3942 1406863002066 CHAP domain; Region: CHAP; pfam05257 1406863002067 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1406863002068 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1406863002069 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1406863002070 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863002071 hypothetical protein; Provisional; Region: PRK12378 1406863002072 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1406863002073 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1406863002074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1406863002075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1406863002076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1406863002077 dimerization interface [polypeptide binding]; other site 1406863002078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863002079 sugar efflux transporter; Region: 2A0120; TIGR00899 1406863002080 putative substrate translocation pore; other site 1406863002081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1406863002082 Serine incorporator (Serinc); Region: Serinc; pfam03348 1406863002083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863002084 Coenzyme A binding pocket [chemical binding]; other site 1406863002085 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1406863002086 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1406863002087 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1406863002088 hypothetical protein; Validated; Region: PRK00124 1406863002089 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1406863002090 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1406863002091 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1406863002092 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1406863002093 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1406863002094 Walker A/P-loop; other site 1406863002095 ATP binding site [chemical binding]; other site 1406863002096 Q-loop/lid; other site 1406863002097 ABC transporter signature motif; other site 1406863002098 Walker B; other site 1406863002099 D-loop; other site 1406863002100 H-loop/switch region; other site 1406863002101 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1406863002102 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1406863002103 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1406863002104 Walker A/P-loop; other site 1406863002105 ATP binding site [chemical binding]; other site 1406863002106 Q-loop/lid; other site 1406863002107 ABC transporter signature motif; other site 1406863002108 Walker B; other site 1406863002109 D-loop; other site 1406863002110 H-loop/switch region; other site 1406863002111 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1406863002112 MarR family; Region: MarR; pfam01047 1406863002113 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1406863002114 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1406863002115 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1406863002116 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1406863002117 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1406863002118 active site 1406863002119 catalytic tetrad [active] 1406863002120 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1406863002121 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1406863002122 transmembrane helices; other site 1406863002123 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1406863002124 DNA photolyase; Region: DNA_photolyase; pfam00875 1406863002125 Predicted membrane protein [Function unknown]; Region: COG4330 1406863002126 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1406863002127 trimer interface [polypeptide binding]; other site 1406863002128 putative Zn binding site [ion binding]; other site 1406863002129 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1406863002130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863002131 putative substrate translocation pore; other site 1406863002132 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1406863002133 putative deacylase active site [active] 1406863002134 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1406863002135 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1406863002136 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1406863002137 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1406863002138 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1406863002139 putative substrate binding site [chemical binding]; other site 1406863002140 putative ATP binding site [chemical binding]; other site 1406863002141 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1406863002142 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1406863002143 active site 1406863002144 phosphorylation site [posttranslational modification] 1406863002145 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1406863002146 active site 1406863002147 P-loop; other site 1406863002148 phosphorylation site [posttranslational modification] 1406863002149 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1406863002150 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1406863002151 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1406863002152 active site 1406863002153 dimer interface [polypeptide binding]; other site 1406863002154 Domain of unknown function DUF21; Region: DUF21; pfam01595 1406863002155 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1406863002156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1406863002157 Transporter associated domain; Region: CorC_HlyC; pfam03471 1406863002158 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1406863002159 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1406863002160 active site 1406863002161 catalytic tetrad [active] 1406863002162 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1406863002163 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1406863002164 Ligand binding site; other site 1406863002165 Putative Catalytic site; other site 1406863002166 DXD motif; other site 1406863002167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1406863002168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1406863002169 dimer interface [polypeptide binding]; other site 1406863002170 phosphorylation site [posttranslational modification] 1406863002171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863002172 ATP binding site [chemical binding]; other site 1406863002173 Mg2+ binding site [ion binding]; other site 1406863002174 G-X-G motif; other site 1406863002175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1406863002176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863002177 active site 1406863002178 phosphorylation site [posttranslational modification] 1406863002179 intermolecular recognition site; other site 1406863002180 dimerization interface [polypeptide binding]; other site 1406863002181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1406863002182 DNA binding site [nucleotide binding] 1406863002183 DoxX; Region: DoxX; pfam07681 1406863002184 Electron transfer DM13; Region: DM13; pfam10517 1406863002185 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1406863002186 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1406863002187 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1406863002188 active site 1406863002189 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1406863002190 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1406863002191 Ligand Binding Site [chemical binding]; other site 1406863002192 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1406863002193 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1406863002194 glutamine binding [chemical binding]; other site 1406863002195 catalytic triad [active] 1406863002196 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1406863002197 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1406863002198 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1406863002199 substrate-cofactor binding pocket; other site 1406863002200 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1406863002201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863002202 catalytic residue [active] 1406863002203 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1406863002204 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1406863002205 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1406863002206 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1406863002207 Sulfatase; Region: Sulfatase; pfam00884 1406863002208 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1406863002209 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1406863002210 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1406863002211 ABC transporter; Region: ABC_tran_2; pfam12848 1406863002212 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1406863002213 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1406863002214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863002215 ATP binding site [chemical binding]; other site 1406863002216 putative Mg++ binding site [ion binding]; other site 1406863002217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1406863002218 nucleotide binding region [chemical binding]; other site 1406863002219 ATP-binding site [chemical binding]; other site 1406863002220 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1406863002221 HRDC domain; Region: HRDC; pfam00570 1406863002222 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1406863002223 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1406863002224 Walker A/P-loop; other site 1406863002225 ATP binding site [chemical binding]; other site 1406863002226 Q-loop/lid; other site 1406863002227 ABC transporter signature motif; other site 1406863002228 Walker B; other site 1406863002229 D-loop; other site 1406863002230 H-loop/switch region; other site 1406863002231 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1406863002232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863002233 dimer interface [polypeptide binding]; other site 1406863002234 conserved gate region; other site 1406863002235 ABC-ATPase subunit interface; other site 1406863002236 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1406863002237 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1406863002238 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1406863002239 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1406863002240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863002241 homodimer interface [polypeptide binding]; other site 1406863002242 catalytic residue [active] 1406863002243 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1406863002244 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1406863002245 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1406863002246 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1406863002247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863002248 putative substrate translocation pore; other site 1406863002249 POT family; Region: PTR2; cl17359 1406863002250 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1406863002251 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1406863002252 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1406863002253 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1406863002254 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1406863002255 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1406863002256 active site 1406863002257 dimer interface [polypeptide binding]; other site 1406863002258 catalytic residues [active] 1406863002259 effector binding site; other site 1406863002260 R2 peptide binding site; other site 1406863002261 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1406863002262 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1406863002263 dimer interface [polypeptide binding]; other site 1406863002264 putative radical transfer pathway; other site 1406863002265 diiron center [ion binding]; other site 1406863002266 tyrosyl radical; other site 1406863002267 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863002268 ABC-ATPase subunit interface; other site 1406863002269 dimer interface [polypeptide binding]; other site 1406863002270 putative PBP binding regions; other site 1406863002271 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863002272 ABC-ATPase subunit interface; other site 1406863002273 dimer interface [polypeptide binding]; other site 1406863002274 putative PBP binding regions; other site 1406863002275 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1406863002276 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1406863002277 Walker A/P-loop; other site 1406863002278 ATP binding site [chemical binding]; other site 1406863002279 Q-loop/lid; other site 1406863002280 ABC transporter signature motif; other site 1406863002281 Walker B; other site 1406863002282 D-loop; other site 1406863002283 H-loop/switch region; other site 1406863002284 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1406863002285 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1406863002286 putative ligand binding residues [chemical binding]; other site 1406863002287 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1406863002288 FAD binding domain; Region: FAD_binding_4; pfam01565 1406863002289 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1406863002290 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1406863002291 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1406863002292 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1406863002293 peptidase T; Region: peptidase-T; TIGR01882 1406863002294 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1406863002295 metal binding site [ion binding]; metal-binding site 1406863002296 dimer interface [polypeptide binding]; other site 1406863002297 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1406863002298 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1406863002299 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1406863002300 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1406863002301 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1406863002302 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1406863002303 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1406863002304 metal binding site [ion binding]; metal-binding site 1406863002305 active site 1406863002306 I-site; other site 1406863002307 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1406863002308 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1406863002309 Mg++ binding site [ion binding]; other site 1406863002310 putative catalytic motif [active] 1406863002311 substrate binding site [chemical binding]; other site 1406863002312 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1406863002313 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1406863002314 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1406863002315 EDD domain protein, DegV family; Region: DegV; TIGR00762 1406863002316 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1406863002317 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1406863002318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863002319 ATP binding site [chemical binding]; other site 1406863002320 putative Mg++ binding site [ion binding]; other site 1406863002321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1406863002322 nucleotide binding region [chemical binding]; other site 1406863002323 ATP-binding site [chemical binding]; other site 1406863002324 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1406863002325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1406863002326 active site 1406863002327 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1406863002328 30S subunit binding site; other site 1406863002329 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1406863002330 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1406863002331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1406863002332 nucleotide binding region [chemical binding]; other site 1406863002333 ATP-binding site [chemical binding]; other site 1406863002334 SEC-C motif; Region: SEC-C; pfam02810 1406863002335 peptide chain release factor 2; Provisional; Region: PRK06746 1406863002336 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1406863002337 RF-1 domain; Region: RF-1; pfam00472 1406863002338 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1406863002339 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1406863002340 Surface antigen [General function prediction only]; Region: COG3942 1406863002341 CHAP domain; Region: CHAP; pfam05257 1406863002342 HD domain; Region: HD_3; cl17350 1406863002343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 1406863002344 excinuclease ABC subunit B; Provisional; Region: PRK05298 1406863002345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863002346 ATP binding site [chemical binding]; other site 1406863002347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1406863002348 nucleotide binding region [chemical binding]; other site 1406863002349 ATP-binding site [chemical binding]; other site 1406863002350 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1406863002351 UvrB/uvrC motif; Region: UVR; pfam02151 1406863002352 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1406863002353 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1406863002354 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1406863002355 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1406863002356 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1406863002357 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1406863002358 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1406863002359 Hpr binding site; other site 1406863002360 active site 1406863002361 homohexamer subunit interaction site [polypeptide binding]; other site 1406863002362 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1406863002363 putative acyl transferase; Provisional; Region: PRK10191 1406863002364 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1406863002365 trimer interface [polypeptide binding]; other site 1406863002366 active site 1406863002367 substrate binding site [chemical binding]; other site 1406863002368 CoA binding site [chemical binding]; other site 1406863002369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1406863002370 binding surface 1406863002371 TPR motif; other site 1406863002372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1406863002373 TPR motif; other site 1406863002374 binding surface 1406863002375 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1406863002376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1406863002377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863002378 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1406863002379 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1406863002380 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1406863002381 phosphate binding site [ion binding]; other site 1406863002382 dimer interface [polypeptide binding]; other site 1406863002383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1406863002384 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1406863002385 Clp protease; Region: CLP_protease; pfam00574 1406863002386 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1406863002387 oligomer interface [polypeptide binding]; other site 1406863002388 active site residues [active] 1406863002389 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1406863002390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1406863002391 NAD(P) binding site [chemical binding]; other site 1406863002392 active site 1406863002393 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1406863002394 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1406863002395 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1406863002396 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1406863002397 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1406863002398 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1406863002399 Phosphoglycerate kinase; Region: PGK; pfam00162 1406863002400 substrate binding site [chemical binding]; other site 1406863002401 hinge regions; other site 1406863002402 ADP binding site [chemical binding]; other site 1406863002403 catalytic site [active] 1406863002404 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1406863002405 triosephosphate isomerase; Provisional; Region: PRK14565 1406863002406 substrate binding site [chemical binding]; other site 1406863002407 dimer interface [polypeptide binding]; other site 1406863002408 catalytic triad [active] 1406863002409 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1406863002410 phosphoglyceromutase; Provisional; Region: PRK05434 1406863002411 enolase; Provisional; Region: eno; PRK00077 1406863002412 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1406863002413 dimer interface [polypeptide binding]; other site 1406863002414 metal binding site [ion binding]; metal-binding site 1406863002415 substrate binding pocket [chemical binding]; other site 1406863002416 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1406863002417 Esterase/lipase [General function prediction only]; Region: COG1647 1406863002418 Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735 1406863002419 ribonuclease R; Region: RNase_R; TIGR02063 1406863002420 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1406863002421 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1406863002422 RNB domain; Region: RNB; pfam00773 1406863002423 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1406863002424 RNA binding site [nucleotide binding]; other site 1406863002425 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1406863002426 SmpB-tmRNA interface; other site 1406863002427 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1406863002428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863002429 Coenzyme A binding pocket [chemical binding]; other site 1406863002430 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863002431 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1406863002432 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1406863002433 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1406863002434 Staphylococcal nuclease homologues; Region: SNc; smart00318 1406863002435 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1406863002436 Catalytic site; other site 1406863002437 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863002438 MULE transposase domain; Region: MULE; pfam10551 1406863002439 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1406863002440 DNA-binding site [nucleotide binding]; DNA binding site 1406863002441 RNA-binding motif; other site 1406863002442 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1406863002443 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1406863002444 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1406863002445 catalytic core [active] 1406863002446 Lysine efflux permease [General function prediction only]; Region: COG1279 1406863002447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1406863002448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1406863002449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1406863002450 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1406863002451 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1406863002452 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1406863002453 active site 1406863002454 catalytic residue [active] 1406863002455 dimer interface [polypeptide binding]; other site 1406863002456 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1406863002457 putative FMN binding site [chemical binding]; other site 1406863002458 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1406863002459 catalytic residues [active] 1406863002460 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1406863002461 ArsC family; Region: ArsC; pfam03960 1406863002462 putative ArsC-like catalytic residues; other site 1406863002463 putative TRX-like catalytic residues [active] 1406863002464 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1406863002465 lipoyl attachment site [posttranslational modification]; other site 1406863002466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1406863002467 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1406863002468 putative active site [active] 1406863002469 putative metal binding site [ion binding]; other site 1406863002470 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1406863002471 catalytic residues [active] 1406863002472 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1406863002473 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1406863002474 Walker A/P-loop; other site 1406863002475 ATP binding site [chemical binding]; other site 1406863002476 Q-loop/lid; other site 1406863002477 ABC transporter signature motif; other site 1406863002478 Walker B; other site 1406863002479 D-loop; other site 1406863002480 H-loop/switch region; other site 1406863002481 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1406863002482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863002483 dimer interface [polypeptide binding]; other site 1406863002484 conserved gate region; other site 1406863002485 ABC-ATPase subunit interface; other site 1406863002486 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1406863002487 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1406863002488 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1406863002489 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1406863002490 Int/Topo IB signature motif; other site 1406863002491 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1406863002492 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863002493 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1406863002494 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863002495 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1406863002496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863002497 non-specific DNA binding site [nucleotide binding]; other site 1406863002498 salt bridge; other site 1406863002499 sequence-specific DNA binding site [nucleotide binding]; other site 1406863002500 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1406863002501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863002502 non-specific DNA binding site [nucleotide binding]; other site 1406863002503 salt bridge; other site 1406863002504 sequence-specific DNA binding site [nucleotide binding]; other site 1406863002505 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1406863002506 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 1406863002507 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1406863002508 Virulence-associated protein E; Region: VirE; pfam05272 1406863002509 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1406863002510 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1406863002511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1406863002512 Predicted membrane protein [Function unknown]; Region: COG2035 1406863002513 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1406863002514 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1406863002515 Walker A/P-loop; other site 1406863002516 ATP binding site [chemical binding]; other site 1406863002517 Q-loop/lid; other site 1406863002518 ABC transporter signature motif; other site 1406863002519 Walker B; other site 1406863002520 D-loop; other site 1406863002521 H-loop/switch region; other site 1406863002522 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1406863002523 FeS assembly protein SufD; Region: sufD; TIGR01981 1406863002524 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1406863002525 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1406863002526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1406863002527 catalytic residue [active] 1406863002528 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1406863002529 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1406863002530 trimerization site [polypeptide binding]; other site 1406863002531 active site 1406863002532 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1406863002533 FeS assembly protein SufB; Region: sufB; TIGR01980 1406863002534 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1406863002535 Domain of unknown function DUF21; Region: DUF21; pfam01595 1406863002536 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1406863002537 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1406863002538 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1406863002539 FMN binding site [chemical binding]; other site 1406863002540 substrate binding site [chemical binding]; other site 1406863002541 putative catalytic residue [active] 1406863002542 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1406863002543 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1406863002544 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1406863002545 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1406863002546 active site 1406863002547 metal binding site [ion binding]; metal-binding site 1406863002548 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1406863002549 lipoyl synthase; Provisional; Region: PRK05481 1406863002550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863002551 FeS/SAM binding site; other site 1406863002552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1406863002553 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1406863002554 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1406863002555 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1406863002556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863002557 active site 1406863002558 motif I; other site 1406863002559 motif II; other site 1406863002560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863002561 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1406863002562 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1406863002563 dimerization interface [polypeptide binding]; other site 1406863002564 ligand binding site [chemical binding]; other site 1406863002565 NADP binding site [chemical binding]; other site 1406863002566 catalytic site [active] 1406863002567 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1406863002568 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1406863002569 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1406863002570 acyl-activating enzyme (AAE) consensus motif; other site 1406863002571 AMP binding site [chemical binding]; other site 1406863002572 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1406863002573 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1406863002574 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1406863002575 DltD N-terminal region; Region: DltD_N; pfam04915 1406863002576 DltD central region; Region: DltD_M; pfam04918 1406863002577 DltD C-terminal region; Region: DltD_C; pfam04914 1406863002578 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1406863002579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1406863002580 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1406863002581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863002582 hypothetical protein; Provisional; Region: PRK13669 1406863002583 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1406863002584 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1406863002585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863002586 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1406863002587 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1406863002588 interface (dimer of trimers) [polypeptide binding]; other site 1406863002589 Substrate-binding/catalytic site; other site 1406863002590 Zn-binding sites [ion binding]; other site 1406863002591 Predicted permease [General function prediction only]; Region: COG2056 1406863002592 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1406863002593 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1406863002594 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1406863002595 CoenzymeA binding site [chemical binding]; other site 1406863002596 subunit interaction site [polypeptide binding]; other site 1406863002597 PHB binding site; other site 1406863002598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1406863002599 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1406863002600 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1406863002601 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1406863002602 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 1406863002603 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1406863002604 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1406863002605 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1406863002606 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1406863002607 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1406863002608 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1406863002609 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1406863002610 Kinase associated protein B; Region: KapB; pfam08810 1406863002611 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1406863002612 active site 1406863002613 general stress protein 13; Validated; Region: PRK08059 1406863002614 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1406863002615 RNA binding site [nucleotide binding]; other site 1406863002616 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1406863002617 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1406863002618 putative active site [active] 1406863002619 putative FMN binding site [chemical binding]; other site 1406863002620 putative substrate binding site [chemical binding]; other site 1406863002621 putative catalytic residue [active] 1406863002622 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1406863002623 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1406863002624 inhibitor-cofactor binding pocket; inhibition site 1406863002625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863002626 catalytic residue [active] 1406863002627 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1406863002628 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1406863002629 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1406863002630 NAD(P) binding site [chemical binding]; other site 1406863002631 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1406863002632 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1406863002633 active site 1406863002634 catalytic site [active] 1406863002635 metal binding site [ion binding]; metal-binding site 1406863002636 argininosuccinate lyase; Provisional; Region: PRK00855 1406863002637 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1406863002638 active sites [active] 1406863002639 tetramer interface [polypeptide binding]; other site 1406863002640 argininosuccinate synthase; Provisional; Region: PRK13820 1406863002641 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1406863002642 ANP binding site [chemical binding]; other site 1406863002643 Substrate Binding Site II [chemical binding]; other site 1406863002644 Substrate Binding Site I [chemical binding]; other site 1406863002645 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1406863002646 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1406863002647 active site 1406863002648 dimer interface [polypeptide binding]; other site 1406863002649 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1406863002650 dimer interface [polypeptide binding]; other site 1406863002651 active site 1406863002652 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1406863002653 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1406863002654 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1406863002655 Catalytic site [active] 1406863002656 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1406863002657 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1406863002658 Catalytic site [active] 1406863002659 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1406863002660 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1406863002661 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1406863002662 Part of AAA domain; Region: AAA_19; pfam13245 1406863002663 Family description; Region: UvrD_C_2; pfam13538 1406863002664 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1406863002665 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1406863002666 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1406863002667 hypothetical protein; Provisional; Region: PRK13673 1406863002668 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1406863002669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1406863002670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863002671 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1406863002672 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1406863002673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863002674 active site 1406863002675 motif I; other site 1406863002676 motif II; other site 1406863002677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863002678 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1406863002679 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1406863002680 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1406863002681 catalytic triad [active] 1406863002682 catalytic triad [active] 1406863002683 oxyanion hole [active] 1406863002684 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1406863002685 Clp amino terminal domain; Region: Clp_N; pfam02861 1406863002686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863002687 Walker A motif; other site 1406863002688 ATP binding site [chemical binding]; other site 1406863002689 Walker B motif; other site 1406863002690 arginine finger; other site 1406863002691 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1406863002692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863002693 Walker A motif; other site 1406863002694 ATP binding site [chemical binding]; other site 1406863002695 Walker B motif; other site 1406863002696 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1406863002697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1406863002698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1406863002699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1406863002700 dimerization interface [polypeptide binding]; other site 1406863002701 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1406863002702 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1406863002703 active site 1406863002704 catalytic residues [active] 1406863002705 metal binding site [ion binding]; metal-binding site 1406863002706 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1406863002707 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1406863002708 substrate binding site [chemical binding]; other site 1406863002709 MAP domain; Region: MAP; pfam03642 1406863002710 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1406863002711 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1406863002712 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1406863002713 dimer interface [polypeptide binding]; other site 1406863002714 active site 1406863002715 CoA binding pocket [chemical binding]; other site 1406863002716 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1406863002717 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1406863002718 dimer interface [polypeptide binding]; other site 1406863002719 active site 1406863002720 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1406863002721 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1406863002722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863002723 dimer interface [polypeptide binding]; other site 1406863002724 conserved gate region; other site 1406863002725 putative PBP binding loops; other site 1406863002726 ABC-ATPase subunit interface; other site 1406863002727 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1406863002728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863002729 dimer interface [polypeptide binding]; other site 1406863002730 conserved gate region; other site 1406863002731 putative PBP binding loops; other site 1406863002732 ABC-ATPase subunit interface; other site 1406863002733 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1406863002734 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863002735 Walker A/P-loop; other site 1406863002736 ATP binding site [chemical binding]; other site 1406863002737 Q-loop/lid; other site 1406863002738 ABC transporter signature motif; other site 1406863002739 Walker B; other site 1406863002740 D-loop; other site 1406863002741 H-loop/switch region; other site 1406863002742 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1406863002743 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1406863002744 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863002745 Walker A/P-loop; other site 1406863002746 ATP binding site [chemical binding]; other site 1406863002747 Q-loop/lid; other site 1406863002748 ABC transporter signature motif; other site 1406863002749 Walker B; other site 1406863002750 D-loop; other site 1406863002751 H-loop/switch region; other site 1406863002752 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1406863002753 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1406863002754 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1406863002755 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1406863002756 peptide binding site [polypeptide binding]; other site 1406863002757 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1406863002758 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1406863002759 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1406863002760 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863002761 Walker A/P-loop; other site 1406863002762 ATP binding site [chemical binding]; other site 1406863002763 Q-loop/lid; other site 1406863002764 ABC transporter signature motif; other site 1406863002765 Walker B; other site 1406863002766 D-loop; other site 1406863002767 H-loop/switch region; other site 1406863002768 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1406863002769 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1406863002770 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863002771 Walker A/P-loop; other site 1406863002772 ATP binding site [chemical binding]; other site 1406863002773 Q-loop/lid; other site 1406863002774 ABC transporter signature motif; other site 1406863002775 Walker B; other site 1406863002776 D-loop; other site 1406863002777 H-loop/switch region; other site 1406863002778 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1406863002779 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1406863002780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863002781 dimer interface [polypeptide binding]; other site 1406863002782 conserved gate region; other site 1406863002783 putative PBP binding loops; other site 1406863002784 ABC-ATPase subunit interface; other site 1406863002785 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1406863002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863002787 dimer interface [polypeptide binding]; other site 1406863002788 conserved gate region; other site 1406863002789 putative PBP binding loops; other site 1406863002790 ABC-ATPase subunit interface; other site 1406863002791 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1406863002792 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1406863002793 active site 1406863002794 HIGH motif; other site 1406863002795 dimer interface [polypeptide binding]; other site 1406863002796 KMSKS motif; other site 1406863002797 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1406863002798 ArsC family; Region: ArsC; pfam03960 1406863002799 putative catalytic residues [active] 1406863002800 thiol/disulfide switch; other site 1406863002801 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863002802 MULE transposase domain; Region: MULE; pfam10551 1406863002803 adaptor protein; Provisional; Region: PRK02315 1406863002804 Competence protein CoiA-like family; Region: CoiA; cl11541 1406863002805 Competence protein CoiA-like family; Region: CoiA; cl11541 1406863002806 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1406863002807 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1406863002808 active site 1406863002809 Zn binding site [ion binding]; other site 1406863002810 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1406863002811 Thioredoxin; Region: Thioredoxin_5; pfam13743 1406863002812 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1406863002813 apolar tunnel; other site 1406863002814 heme binding site [chemical binding]; other site 1406863002815 dimerization interface [polypeptide binding]; other site 1406863002816 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1406863002817 putative active site [active] 1406863002818 putative metal binding residues [ion binding]; other site 1406863002819 signature motif; other site 1406863002820 putative triphosphate binding site [ion binding]; other site 1406863002821 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1406863002822 synthetase active site [active] 1406863002823 NTP binding site [chemical binding]; other site 1406863002824 metal binding site [ion binding]; metal-binding site 1406863002825 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1406863002826 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1406863002827 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1406863002828 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1406863002829 active site 1406863002830 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1406863002831 MgtE intracellular N domain; Region: MgtE_N; smart00924 1406863002832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1406863002833 Divalent cation transporter; Region: MgtE; pfam01769 1406863002834 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1406863002835 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1406863002836 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1406863002837 TrkA-N domain; Region: TrkA_N; pfam02254 1406863002838 TrkA-C domain; Region: TrkA_C; pfam02080 1406863002839 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1406863002840 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1406863002841 NAD binding site [chemical binding]; other site 1406863002842 homotetramer interface [polypeptide binding]; other site 1406863002843 homodimer interface [polypeptide binding]; other site 1406863002844 substrate binding site [chemical binding]; other site 1406863002845 active site 1406863002846 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1406863002847 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1406863002848 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1406863002849 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1406863002850 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1406863002851 Putative esterase; Region: Esterase; pfam00756 1406863002852 hypothetical protein; Provisional; Region: PRK13679 1406863002853 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1406863002854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863002855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863002856 putative substrate translocation pore; other site 1406863002857 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1406863002858 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1406863002859 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1406863002860 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1406863002861 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1406863002862 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1406863002863 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1406863002864 YueH-like protein; Region: YueH; pfam14166 1406863002865 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1406863002866 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1406863002867 G1 box; other site 1406863002868 putative GEF interaction site [polypeptide binding]; other site 1406863002869 GTP/Mg2+ binding site [chemical binding]; other site 1406863002870 Switch I region; other site 1406863002871 G2 box; other site 1406863002872 G3 box; other site 1406863002873 Switch II region; other site 1406863002874 G4 box; other site 1406863002875 G5 box; other site 1406863002876 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1406863002877 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1406863002878 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1406863002879 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1406863002880 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1406863002881 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1406863002882 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1406863002883 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1406863002884 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1406863002885 active site 1406863002886 metal binding site [ion binding]; metal-binding site 1406863002887 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1406863002888 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1406863002889 IDEAL domain; Region: IDEAL; pfam08858 1406863002890 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1406863002891 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1406863002892 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1406863002893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1406863002894 CAAX protease self-immunity; Region: Abi; pfam02517 1406863002895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1406863002896 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1406863002897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1406863002898 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1406863002899 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1406863002900 Walker A/P-loop; other site 1406863002901 ATP binding site [chemical binding]; other site 1406863002902 Q-loop/lid; other site 1406863002903 ABC transporter signature motif; other site 1406863002904 Walker B; other site 1406863002905 D-loop; other site 1406863002906 H-loop/switch region; other site 1406863002907 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1406863002908 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1406863002909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1406863002910 Predicted membrane protein [Function unknown]; Region: COG2259 1406863002911 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1406863002912 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1406863002913 siderophore binding site; other site 1406863002914 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1406863002915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863002916 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1406863002917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1406863002918 Coenzyme A binding pocket [chemical binding]; other site 1406863002919 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1406863002920 UbiA prenyltransferase family; Region: UbiA; pfam01040 1406863002921 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1406863002922 isochorismate synthases; Region: isochor_syn; TIGR00543 1406863002923 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1406863002924 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1406863002925 dimer interface [polypeptide binding]; other site 1406863002926 tetramer interface [polypeptide binding]; other site 1406863002927 PYR/PP interface [polypeptide binding]; other site 1406863002928 TPP binding site [chemical binding]; other site 1406863002929 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1406863002930 TPP-binding site; other site 1406863002931 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1406863002932 PGAP1-like protein; Region: PGAP1; pfam07819 1406863002933 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1406863002934 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1406863002935 substrate binding site [chemical binding]; other site 1406863002936 oxyanion hole (OAH) forming residues; other site 1406863002937 trimer interface [polypeptide binding]; other site 1406863002938 Staphostatin B; Region: Staphostatin_B; pfam09023 1406863002939 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1406863002940 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1406863002941 aminotransferase A; Validated; Region: PRK07683 1406863002942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1406863002943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863002944 homodimer interface [polypeptide binding]; other site 1406863002945 catalytic residue [active] 1406863002946 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1406863002947 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1406863002948 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1406863002949 MarR family; Region: MarR; pfam01047 1406863002950 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1406863002951 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1406863002952 amidase catalytic site [active] 1406863002953 Zn binding residues [ion binding]; other site 1406863002954 substrate binding site [chemical binding]; other site 1406863002955 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1406863002956 Lysozyme subfamily 2; Region: LYZ2; smart00047 1406863002957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863002958 Coenzyme A binding pocket [chemical binding]; other site 1406863002959 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1406863002960 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1406863002961 Beta-lactamase; Region: Beta-lactamase; pfam00144 1406863002962 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1406863002963 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1406863002964 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1406863002965 Subunit I/III interface [polypeptide binding]; other site 1406863002966 Subunit III/IV interface [polypeptide binding]; other site 1406863002967 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1406863002968 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1406863002969 D-pathway; other site 1406863002970 Putative ubiquinol binding site [chemical binding]; other site 1406863002971 Low-spin heme (heme b) binding site [chemical binding]; other site 1406863002972 Putative water exit pathway; other site 1406863002973 Binuclear center (heme o3/CuB) [ion binding]; other site 1406863002974 K-pathway; other site 1406863002975 Putative proton exit pathway; other site 1406863002976 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1406863002977 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1406863002978 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1406863002979 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1406863002980 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1406863002981 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1406863002982 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1406863002983 homodimer interface [polypeptide binding]; other site 1406863002984 NADP binding site [chemical binding]; other site 1406863002985 substrate binding site [chemical binding]; other site 1406863002986 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1406863002987 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1406863002988 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1406863002989 NAD binding site [chemical binding]; other site 1406863002990 ATP-grasp domain; Region: ATP-grasp; pfam02222 1406863002991 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1406863002992 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1406863002993 ATP binding site [chemical binding]; other site 1406863002994 active site 1406863002995 substrate binding site [chemical binding]; other site 1406863002996 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1406863002997 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1406863002998 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1406863002999 putative active site [active] 1406863003000 catalytic triad [active] 1406863003001 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1406863003002 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1406863003003 dimerization interface [polypeptide binding]; other site 1406863003004 ATP binding site [chemical binding]; other site 1406863003005 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1406863003006 dimerization interface [polypeptide binding]; other site 1406863003007 ATP binding site [chemical binding]; other site 1406863003008 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1406863003009 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1406863003010 active site 1406863003011 tetramer interface [polypeptide binding]; other site 1406863003012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1406863003013 active site 1406863003014 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1406863003015 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1406863003016 dimerization interface [polypeptide binding]; other site 1406863003017 putative ATP binding site [chemical binding]; other site 1406863003018 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1406863003019 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1406863003020 active site 1406863003021 substrate binding site [chemical binding]; other site 1406863003022 cosubstrate binding site; other site 1406863003023 catalytic site [active] 1406863003024 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1406863003025 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1406863003026 purine monophosphate binding site [chemical binding]; other site 1406863003027 dimer interface [polypeptide binding]; other site 1406863003028 putative catalytic residues [active] 1406863003029 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1406863003030 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1406863003031 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1406863003032 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1406863003033 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1406863003034 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1406863003035 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1406863003036 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1406863003037 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1406863003038 Walker A/P-loop; other site 1406863003039 ATP binding site [chemical binding]; other site 1406863003040 Q-loop/lid; other site 1406863003041 ABC transporter signature motif; other site 1406863003042 Walker B; other site 1406863003043 D-loop; other site 1406863003044 H-loop/switch region; other site 1406863003045 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1406863003046 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1406863003047 Walker A/P-loop; other site 1406863003048 ATP binding site [chemical binding]; other site 1406863003049 Q-loop/lid; other site 1406863003050 ABC transporter signature motif; other site 1406863003051 Walker B; other site 1406863003052 D-loop; other site 1406863003053 H-loop/switch region; other site 1406863003054 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1406863003055 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1406863003056 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1406863003057 putative RNA binding site [nucleotide binding]; other site 1406863003058 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1406863003059 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1406863003060 dimerization domain swap beta strand [polypeptide binding]; other site 1406863003061 regulatory protein interface [polypeptide binding]; other site 1406863003062 active site 1406863003063 regulatory phosphorylation site [posttranslational modification]; other site 1406863003064 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1406863003065 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1406863003066 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1406863003067 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1406863003068 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1406863003069 catalytic residues [active] 1406863003070 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1406863003071 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1406863003072 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1406863003073 TrkA-N domain; Region: TrkA_N; pfam02254 1406863003074 TrkA-C domain; Region: TrkA_C; pfam02080 1406863003075 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1406863003076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1406863003077 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1406863003078 hypothetical protein; Provisional; Region: PRK13667 1406863003079 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1406863003080 active site 1406863003081 catalytic residues [active] 1406863003082 metal binding site [ion binding]; metal-binding site 1406863003083 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1406863003084 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1406863003085 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1406863003086 TPP-binding site [chemical binding]; other site 1406863003087 tetramer interface [polypeptide binding]; other site 1406863003088 heterodimer interface [polypeptide binding]; other site 1406863003089 phosphorylation loop region [posttranslational modification] 1406863003090 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1406863003091 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1406863003092 alpha subunit interface [polypeptide binding]; other site 1406863003093 TPP binding site [chemical binding]; other site 1406863003094 heterodimer interface [polypeptide binding]; other site 1406863003095 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1406863003096 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1406863003097 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1406863003098 E3 interaction surface; other site 1406863003099 lipoyl attachment site [posttranslational modification]; other site 1406863003100 e3 binding domain; Region: E3_binding; pfam02817 1406863003101 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1406863003102 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1406863003103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1406863003104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863003105 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1406863003106 hypothetical protein; Provisional; Region: PRK04387 1406863003107 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1406863003108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863003109 non-specific DNA binding site [nucleotide binding]; other site 1406863003110 salt bridge; other site 1406863003111 sequence-specific DNA binding site [nucleotide binding]; other site 1406863003112 Cupin domain; Region: Cupin_2; pfam07883 1406863003113 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1406863003114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863003115 Walker A/P-loop; other site 1406863003116 ATP binding site [chemical binding]; other site 1406863003117 Q-loop/lid; other site 1406863003118 ABC transporter signature motif; other site 1406863003119 Walker B; other site 1406863003120 D-loop; other site 1406863003121 H-loop/switch region; other site 1406863003122 TOBE domain; Region: TOBE_2; pfam08402 1406863003123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863003124 putative PBP binding loops; other site 1406863003125 dimer interface [polypeptide binding]; other site 1406863003126 ABC-ATPase subunit interface; other site 1406863003127 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1406863003128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863003129 dimer interface [polypeptide binding]; other site 1406863003130 conserved gate region; other site 1406863003131 putative PBP binding loops; other site 1406863003132 ABC-ATPase subunit interface; other site 1406863003133 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1406863003134 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 1406863003135 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1406863003136 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1406863003137 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1406863003138 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1406863003139 manganese transport protein MntH; Reviewed; Region: PRK00701 1406863003140 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1406863003141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1406863003142 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1406863003143 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1406863003144 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1406863003145 active site 1406863003146 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1406863003147 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1406863003148 G1 box; other site 1406863003149 putative GEF interaction site [polypeptide binding]; other site 1406863003150 GTP/Mg2+ binding site [chemical binding]; other site 1406863003151 Switch I region; other site 1406863003152 G2 box; other site 1406863003153 G3 box; other site 1406863003154 Switch II region; other site 1406863003155 G4 box; other site 1406863003156 G5 box; other site 1406863003157 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1406863003158 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1406863003159 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1406863003160 hypothetical protein; Provisional; Region: PRK13666 1406863003161 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1406863003162 pyruvate carboxylase; Reviewed; Region: PRK12999 1406863003163 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1406863003164 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1406863003165 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1406863003166 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1406863003167 active site 1406863003168 catalytic residues [active] 1406863003169 metal binding site [ion binding]; metal-binding site 1406863003170 homodimer binding site [polypeptide binding]; other site 1406863003171 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1406863003172 carboxyltransferase (CT) interaction site; other site 1406863003173 biotinylation site [posttranslational modification]; other site 1406863003174 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1406863003175 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1406863003176 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1406863003177 UbiA prenyltransferase family; Region: UbiA; pfam01040 1406863003178 Predicted membrane protein [Function unknown]; Region: COG2322 1406863003179 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1406863003180 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1406863003181 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1406863003182 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1406863003183 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1406863003184 putative active site [active] 1406863003185 catalytic site [active] 1406863003186 putative metal binding site [ion binding]; other site 1406863003187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1406863003188 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1406863003189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863003190 S-adenosylmethionine binding site [chemical binding]; other site 1406863003191 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1406863003192 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1406863003193 active site 1406863003194 (T/H)XGH motif; other site 1406863003195 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1406863003196 hypothetical protein; Provisional; Region: PRK13670 1406863003197 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1406863003198 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1406863003199 prophage phiSa1(Z172) 1406863003200 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1406863003201 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1406863003202 catalytic residues [active] 1406863003203 catalytic nucleophile [active] 1406863003204 Presynaptic Site I dimer interface [polypeptide binding]; other site 1406863003205 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1406863003206 Synaptic Flat tetramer interface [polypeptide binding]; other site 1406863003207 Synaptic Site I dimer interface [polypeptide binding]; other site 1406863003208 DNA binding site [nucleotide binding] 1406863003209 Recombinase; Region: Recombinase; pfam07508 1406863003210 PemK-like protein; Region: PemK; pfam02452 1406863003211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863003212 non-specific DNA binding site [nucleotide binding]; other site 1406863003213 salt bridge; other site 1406863003214 sequence-specific DNA binding site [nucleotide binding]; other site 1406863003215 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1406863003216 Catalytic site [active] 1406863003217 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1406863003218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863003219 non-specific DNA binding site [nucleotide binding]; other site 1406863003220 salt bridge; other site 1406863003221 sequence-specific DNA binding site [nucleotide binding]; other site 1406863003222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863003223 non-specific DNA binding site [nucleotide binding]; other site 1406863003224 salt bridge; other site 1406863003225 sequence-specific DNA binding site [nucleotide binding]; other site 1406863003226 Phage anti-repressor protein [Transcription]; Region: COG3561 1406863003227 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1406863003228 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1406863003229 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 1406863003230 ERF superfamily; Region: ERF; pfam04404 1406863003231 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1406863003232 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1406863003233 dimer interface [polypeptide binding]; other site 1406863003234 ssDNA binding site [nucleotide binding]; other site 1406863003235 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1406863003236 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1406863003237 phage replisome organizer, putative, N-terminal region; Region: phage_rep_org_N; TIGR01714 1406863003238 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1406863003239 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1406863003240 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1406863003241 Walker A motif; other site 1406863003242 ATP binding site [chemical binding]; other site 1406863003243 Walker B motif; other site 1406863003244 DNA binding loops [nucleotide binding] 1406863003245 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 1406863003246 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 1406863003247 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1406863003248 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 1406863003249 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1406863003250 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 1406863003251 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1406863003252 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1406863003253 dUTPase; Region: dUTPase_2; pfam08761 1406863003254 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1406863003255 active site 1406863003256 homodimer interface [polypeptide binding]; other site 1406863003257 metal binding site [ion binding]; metal-binding site 1406863003258 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1406863003259 Transcriptional activator RinB; Region: RinB; pfam06116 1406863003260 Phage terminase large subunit; Region: Terminase_3; cl12054 1406863003261 Terminase-like family; Region: Terminase_6; pfam03237 1406863003262 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1406863003263 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1406863003264 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 1406863003265 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1406863003266 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1406863003267 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 1406863003268 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1406863003269 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1406863003270 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1406863003271 Phage protein; Region: DUF3647; pfam12363 1406863003272 Phage-related protein [Function unknown]; Region: COG5412 1406863003273 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1406863003274 Phage tail protein; Region: Sipho_tail; pfam05709 1406863003275 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1406863003276 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1406863003277 active site 1406863003278 catalytic triad [active] 1406863003279 oxyanion hole [active] 1406863003280 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1406863003281 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 1406863003282 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1406863003283 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1406863003284 CHAP domain; Region: CHAP; pfam05257 1406863003285 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1406863003286 Lysozyme subfamily 2; Region: LYZ2; smart00047 1406863003287 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1406863003288 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1406863003289 Phage tail repeat like; Region: PTR; pfam12789 1406863003290 Bacteriophage holin; Region: Phage_holin_1; pfam04531 1406863003291 CHAP domain; Region: CHAP; pfam05257 1406863003292 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1406863003293 amidase catalytic site [active] 1406863003294 Zn binding residues [ion binding]; other site 1406863003295 substrate binding site [chemical binding]; other site 1406863003296 Bacterial SH3 domain; Region: SH3_5; pfam08460 1406863003297 heme uptake protein IsdB; Region: IsdB; TIGR03657 1406863003298 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863003299 NEAr Transporter domain; Region: NEAT; smart00725 1406863003300 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1406863003301 heme-binding site [chemical binding]; other site 1406863003302 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1406863003303 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1406863003304 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1406863003305 heme-binding site [chemical binding]; other site 1406863003306 heme uptake protein IsdC; Region: IsdC; TIGR03656 1406863003307 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1406863003308 heme-binding site [chemical binding]; other site 1406863003309 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1406863003310 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1406863003311 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1406863003312 intersubunit interface [polypeptide binding]; other site 1406863003313 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1406863003314 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863003315 ABC-ATPase subunit interface; other site 1406863003316 dimer interface [polypeptide binding]; other site 1406863003317 putative PBP binding regions; other site 1406863003318 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1406863003319 active site 1406863003320 catalytic site [active] 1406863003321 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 1406863003322 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1406863003323 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1406863003324 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1406863003325 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1406863003326 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1406863003327 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1406863003328 dimer interface [polypeptide binding]; other site 1406863003329 motif 1; other site 1406863003330 active site 1406863003331 motif 2; other site 1406863003332 motif 3; other site 1406863003333 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1406863003334 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1406863003335 putative tRNA-binding site [nucleotide binding]; other site 1406863003336 B3/4 domain; Region: B3_4; pfam03483 1406863003337 tRNA synthetase B5 domain; Region: B5; smart00874 1406863003338 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1406863003339 dimer interface [polypeptide binding]; other site 1406863003340 motif 1; other site 1406863003341 motif 3; other site 1406863003342 motif 2; other site 1406863003343 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1406863003344 ribonuclease HIII; Provisional; Region: PRK00996 1406863003345 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1406863003346 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1406863003347 RNA/DNA hybrid binding site [nucleotide binding]; other site 1406863003348 active site 1406863003349 Cell division protein ZapA; Region: ZapA; cl01146 1406863003350 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1406863003351 Colicin V production protein; Region: Colicin_V; pfam02674 1406863003352 hypothetical protein; Provisional; Region: PRK08609 1406863003353 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1406863003354 active site 1406863003355 primer binding site [nucleotide binding]; other site 1406863003356 NTP binding site [chemical binding]; other site 1406863003357 metal binding triad [ion binding]; metal-binding site 1406863003358 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1406863003359 active site 1406863003360 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1406863003361 MutS domain III; Region: MutS_III; pfam05192 1406863003362 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1406863003363 Walker A/P-loop; other site 1406863003364 ATP binding site [chemical binding]; other site 1406863003365 Q-loop/lid; other site 1406863003366 ABC transporter signature motif; other site 1406863003367 Walker B; other site 1406863003368 D-loop; other site 1406863003369 H-loop/switch region; other site 1406863003370 Smr domain; Region: Smr; pfam01713 1406863003371 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1406863003372 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1406863003373 catalytic residues [active] 1406863003374 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1406863003375 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1406863003376 GIY-YIG motif/motif A; other site 1406863003377 active site 1406863003378 catalytic site [active] 1406863003379 putative DNA binding site [nucleotide binding]; other site 1406863003380 metal binding site [ion binding]; metal-binding site 1406863003381 UvrB/uvrC motif; Region: UVR; pfam02151 1406863003382 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1406863003383 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1406863003384 putative Iron-sulfur protein interface [polypeptide binding]; other site 1406863003385 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1406863003386 proximal heme binding site [chemical binding]; other site 1406863003387 distal heme binding site [chemical binding]; other site 1406863003388 putative dimer interface [polypeptide binding]; other site 1406863003389 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1406863003390 L-aspartate oxidase; Provisional; Region: PRK06175 1406863003391 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1406863003392 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1406863003393 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1406863003394 glutamate racemase; Provisional; Region: PRK00865 1406863003395 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1406863003396 active site 1406863003397 dimerization interface [polypeptide binding]; other site 1406863003398 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1406863003399 active site 1406863003400 metal binding site [ion binding]; metal-binding site 1406863003401 homotetramer interface [polypeptide binding]; other site 1406863003402 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1406863003403 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 1406863003404 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1406863003405 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1406863003406 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1406863003407 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863003408 MULE transposase domain; Region: MULE; pfam10551 1406863003409 superantigen-like protein; Reviewed; Region: PRK13350 1406863003410 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863003411 superantigen-like protein; Reviewed; Region: PRK13349 1406863003412 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863003413 superantigen-like protein; Reviewed; Region: PRK13043 1406863003414 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863003415 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1406863003416 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1406863003417 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1406863003418 carbamate kinase; Reviewed; Region: PRK12686 1406863003419 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1406863003420 putative substrate binding site [chemical binding]; other site 1406863003421 nucleotide binding site [chemical binding]; other site 1406863003422 nucleotide binding site [chemical binding]; other site 1406863003423 homodimer interface [polypeptide binding]; other site 1406863003424 Predicted membrane protein [Function unknown]; Region: COG1288 1406863003425 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1406863003426 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1406863003427 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1406863003428 gating phenylalanine in ion channel; other site 1406863003429 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1406863003430 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1406863003431 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1406863003432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863003433 motif II; other site 1406863003434 hypothetical protein; Provisional; Region: PRK13688 1406863003435 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1406863003436 Coenzyme A binding pocket [chemical binding]; other site 1406863003437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1406863003438 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1406863003439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1406863003440 MraZ protein; Region: MraZ; pfam02381 1406863003441 MraZ protein; Region: MraZ; pfam02381 1406863003442 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1406863003443 MraW methylase family; Region: Methyltransf_5; pfam01795 1406863003444 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1406863003445 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1406863003446 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1406863003447 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1406863003448 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1406863003449 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1406863003450 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1406863003451 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1406863003452 Mg++ binding site [ion binding]; other site 1406863003453 putative catalytic motif [active] 1406863003454 putative substrate binding site [chemical binding]; other site 1406863003455 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1406863003456 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1406863003457 NAD binding site [chemical binding]; other site 1406863003458 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1406863003459 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1406863003460 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1406863003461 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1406863003462 Cell division protein FtsQ; Region: FtsQ; pfam03799 1406863003463 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1406863003464 Cell division protein FtsA; Region: FtsA; smart00842 1406863003465 Cell division protein FtsA; Region: FtsA; pfam14450 1406863003466 cell division protein FtsZ; Validated; Region: PRK09330 1406863003467 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1406863003468 nucleotide binding site [chemical binding]; other site 1406863003469 SulA interaction site; other site 1406863003470 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1406863003471 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1406863003472 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1406863003473 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1406863003474 catalytic residue [active] 1406863003475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1406863003476 YGGT family; Region: YGGT; pfam02325 1406863003477 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1406863003478 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1406863003479 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1406863003480 DivIVA domain; Region: DivI1A_domain; TIGR03544 1406863003481 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1406863003482 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1406863003483 HIGH motif; other site 1406863003484 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1406863003485 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1406863003486 active site 1406863003487 KMSKS motif; other site 1406863003488 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1406863003489 tRNA binding surface [nucleotide binding]; other site 1406863003490 anticodon binding site; other site 1406863003491 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1406863003492 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1406863003493 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1406863003494 active site 1406863003495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1406863003496 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1406863003497 lipoprotein signal peptidase; Provisional; Region: PRK14787 1406863003498 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1406863003499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1406863003500 RNA binding surface [nucleotide binding]; other site 1406863003501 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1406863003502 active site 1406863003503 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1406863003504 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1406863003505 uracil transporter; Provisional; Region: PRK10720 1406863003506 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1406863003507 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1406863003508 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1406863003509 dihydroorotase; Validated; Region: pyrC; PRK09357 1406863003510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1406863003511 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1406863003512 active site 1406863003513 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1406863003514 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1406863003515 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1406863003516 catalytic site [active] 1406863003517 subunit interface [polypeptide binding]; other site 1406863003518 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1406863003519 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1406863003520 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1406863003521 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1406863003522 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1406863003523 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1406863003524 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1406863003525 IMP binding site; other site 1406863003526 dimer interface [polypeptide binding]; other site 1406863003527 interdomain contacts; other site 1406863003528 partial ornithine binding site; other site 1406863003529 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1406863003530 active site 1406863003531 dimer interface [polypeptide binding]; other site 1406863003532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1406863003533 active site 1406863003534 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1406863003535 dimer interface [polypeptide binding]; other site 1406863003536 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1406863003537 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1406863003538 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1406863003539 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1406863003540 catalytic site [active] 1406863003541 G-X2-G-X-G-K; other site 1406863003542 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1406863003543 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1406863003544 Flavoprotein; Region: Flavoprotein; pfam02441 1406863003545 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1406863003546 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1406863003547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863003548 ATP binding site [chemical binding]; other site 1406863003549 putative Mg++ binding site [ion binding]; other site 1406863003550 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1406863003551 nucleotide binding region [chemical binding]; other site 1406863003552 ATP-binding site [chemical binding]; other site 1406863003553 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1406863003554 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1406863003555 active site 1406863003556 catalytic residues [active] 1406863003557 metal binding site [ion binding]; metal-binding site 1406863003558 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1406863003559 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1406863003560 putative active site [active] 1406863003561 substrate binding site [chemical binding]; other site 1406863003562 putative cosubstrate binding site; other site 1406863003563 catalytic site [active] 1406863003564 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1406863003565 substrate binding site [chemical binding]; other site 1406863003566 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1406863003567 NusB family; Region: NusB; pfam01029 1406863003568 putative RNA binding site [nucleotide binding]; other site 1406863003569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863003570 S-adenosylmethionine binding site [chemical binding]; other site 1406863003571 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1406863003572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863003573 FeS/SAM binding site; other site 1406863003574 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1406863003575 Protein phosphatase 2C; Region: PP2C; pfam00481 1406863003576 active site 1406863003577 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1406863003578 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1406863003579 active site 1406863003580 ATP binding site [chemical binding]; other site 1406863003581 substrate binding site [chemical binding]; other site 1406863003582 activation loop (A-loop); other site 1406863003583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1406863003584 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1406863003585 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1406863003586 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1406863003587 Predicted GTPases [General function prediction only]; Region: COG1162 1406863003588 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1406863003589 RNA binding site [nucleotide binding]; other site 1406863003590 homodimer interface [polypeptide binding]; other site 1406863003591 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1406863003592 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1406863003593 GTP/Mg2+ binding site [chemical binding]; other site 1406863003594 G4 box; other site 1406863003595 G5 box; other site 1406863003596 G1 box; other site 1406863003597 Switch I region; other site 1406863003598 G2 box; other site 1406863003599 G3 box; other site 1406863003600 Switch II region; other site 1406863003601 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1406863003602 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1406863003603 substrate binding site [chemical binding]; other site 1406863003604 hexamer interface [polypeptide binding]; other site 1406863003605 metal binding site [ion binding]; metal-binding site 1406863003606 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1406863003607 Thiamine pyrophosphokinase; Region: TPK; cd07995 1406863003608 active site 1406863003609 dimerization interface [polypeptide binding]; other site 1406863003610 thiamine binding site [chemical binding]; other site 1406863003611 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1406863003612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1406863003613 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1406863003614 DAK2 domain; Region: Dak2; pfam02734 1406863003615 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1406863003616 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1406863003617 generic binding surface II; other site 1406863003618 ssDNA binding site; other site 1406863003619 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863003620 ATP binding site [chemical binding]; other site 1406863003621 putative Mg++ binding site [ion binding]; other site 1406863003622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1406863003623 nucleotide binding region [chemical binding]; other site 1406863003624 ATP-binding site [chemical binding]; other site 1406863003625 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1406863003626 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1406863003627 active site 2 [active] 1406863003628 active site 1 [active] 1406863003629 putative phosphate acyltransferase; Provisional; Region: PRK05331 1406863003630 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1406863003631 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1406863003632 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1406863003633 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1406863003634 NAD(P) binding site [chemical binding]; other site 1406863003635 homotetramer interface [polypeptide binding]; other site 1406863003636 homodimer interface [polypeptide binding]; other site 1406863003637 active site 1406863003638 acyl carrier protein; Provisional; Region: acpP; PRK00982 1406863003639 ribonuclease III; Reviewed; Region: rnc; PRK00102 1406863003640 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1406863003641 dimerization interface [polypeptide binding]; other site 1406863003642 active site 1406863003643 metal binding site [ion binding]; metal-binding site 1406863003644 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1406863003645 dsRNA binding site [nucleotide binding]; other site 1406863003646 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1406863003647 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1406863003648 Walker A/P-loop; other site 1406863003649 ATP binding site [chemical binding]; other site 1406863003650 Q-loop/lid; other site 1406863003651 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1406863003652 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1406863003653 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1406863003654 ABC transporter signature motif; other site 1406863003655 Walker B; other site 1406863003656 D-loop; other site 1406863003657 H-loop/switch region; other site 1406863003658 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1406863003659 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1406863003660 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1406863003661 P loop; other site 1406863003662 GTP binding site [chemical binding]; other site 1406863003663 putative DNA-binding protein; Validated; Region: PRK00118 1406863003664 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1406863003665 signal recognition particle protein; Provisional; Region: PRK10867 1406863003666 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1406863003667 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1406863003668 P loop; other site 1406863003669 GTP binding site [chemical binding]; other site 1406863003670 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1406863003671 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1406863003672 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1406863003673 RimM N-terminal domain; Region: RimM; pfam01782 1406863003674 PRC-barrel domain; Region: PRC; pfam05239 1406863003675 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1406863003676 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1406863003677 Predicted membrane protein [Function unknown]; Region: COG4485 1406863003678 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1406863003679 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1406863003680 GTP/Mg2+ binding site [chemical binding]; other site 1406863003681 G4 box; other site 1406863003682 G5 box; other site 1406863003683 G1 box; other site 1406863003684 Switch I region; other site 1406863003685 G2 box; other site 1406863003686 G3 box; other site 1406863003687 Switch II region; other site 1406863003688 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1406863003689 RNA/DNA hybrid binding site [nucleotide binding]; other site 1406863003690 active site 1406863003691 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1406863003692 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1406863003693 CoA-ligase; Region: Ligase_CoA; pfam00549 1406863003694 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1406863003695 CoA binding domain; Region: CoA_binding; pfam02629 1406863003696 CoA-ligase; Region: Ligase_CoA; pfam00549 1406863003697 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1406863003698 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1406863003699 CHAP domain; Region: CHAP; pfam05257 1406863003700 FemAB family; Region: FemAB; pfam02388 1406863003701 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1406863003702 DNA protecting protein DprA; Region: dprA; TIGR00732 1406863003703 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1406863003704 DNA topoisomerase I; Validated; Region: PRK05582 1406863003705 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1406863003706 active site 1406863003707 interdomain interaction site; other site 1406863003708 putative metal-binding site [ion binding]; other site 1406863003709 nucleotide binding site [chemical binding]; other site 1406863003710 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1406863003711 domain I; other site 1406863003712 DNA binding groove [nucleotide binding] 1406863003713 phosphate binding site [ion binding]; other site 1406863003714 domain II; other site 1406863003715 domain III; other site 1406863003716 nucleotide binding site [chemical binding]; other site 1406863003717 catalytic site [active] 1406863003718 domain IV; other site 1406863003719 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1406863003720 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1406863003721 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1406863003722 Glucose inhibited division protein A; Region: GIDA; pfam01134 1406863003723 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1406863003724 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1406863003725 active site 1406863003726 DNA binding site [nucleotide binding] 1406863003727 Int/Topo IB signature motif; other site 1406863003728 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1406863003729 active site 1406863003730 HslU subunit interaction site [polypeptide binding]; other site 1406863003731 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1406863003732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863003733 Walker A motif; other site 1406863003734 ATP binding site [chemical binding]; other site 1406863003735 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1406863003736 Walker B motif; other site 1406863003737 arginine finger; other site 1406863003738 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1406863003739 transcriptional repressor CodY; Validated; Region: PRK04158 1406863003740 CodY GAF-like domain; Region: CodY; pfam06018 1406863003741 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1406863003742 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1406863003743 rRNA interaction site [nucleotide binding]; other site 1406863003744 S8 interaction site; other site 1406863003745 putative laminin-1 binding site; other site 1406863003746 elongation factor Ts; Provisional; Region: tsf; PRK09377 1406863003747 UBA/TS-N domain; Region: UBA; pfam00627 1406863003748 Elongation factor TS; Region: EF_TS; pfam00889 1406863003749 Elongation factor TS; Region: EF_TS; pfam00889 1406863003750 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1406863003751 putative nucleotide binding site [chemical binding]; other site 1406863003752 uridine monophosphate binding site [chemical binding]; other site 1406863003753 homohexameric interface [polypeptide binding]; other site 1406863003754 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1406863003755 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1406863003756 hinge region; other site 1406863003757 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1406863003758 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1406863003759 catalytic residue [active] 1406863003760 putative FPP diphosphate binding site; other site 1406863003761 putative FPP binding hydrophobic cleft; other site 1406863003762 dimer interface [polypeptide binding]; other site 1406863003763 putative IPP diphosphate binding site; other site 1406863003764 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1406863003765 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1406863003766 RIP metalloprotease RseP; Region: TIGR00054 1406863003767 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1406863003768 active site 1406863003769 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1406863003770 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1406863003771 protein binding site [polypeptide binding]; other site 1406863003772 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1406863003773 putative substrate binding region [chemical binding]; other site 1406863003774 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1406863003775 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1406863003776 dimer interface [polypeptide binding]; other site 1406863003777 motif 1; other site 1406863003778 active site 1406863003779 motif 2; other site 1406863003780 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1406863003781 putative deacylase active site [active] 1406863003782 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1406863003783 active site 1406863003784 motif 3; other site 1406863003785 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1406863003786 anticodon binding site; other site 1406863003787 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1406863003788 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1406863003789 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1406863003790 generic binding surface II; other site 1406863003791 generic binding surface I; other site 1406863003792 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1406863003793 active site 1406863003794 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1406863003795 active site 1406863003796 catalytic site [active] 1406863003797 substrate binding site [chemical binding]; other site 1406863003798 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1406863003799 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1406863003800 Sm and related proteins; Region: Sm_like; cl00259 1406863003801 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1406863003802 putative oligomer interface [polypeptide binding]; other site 1406863003803 putative RNA binding site [nucleotide binding]; other site 1406863003804 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1406863003805 NusA N-terminal domain; Region: NusA_N; pfam08529 1406863003806 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1406863003807 RNA binding site [nucleotide binding]; other site 1406863003808 homodimer interface [polypeptide binding]; other site 1406863003809 NusA-like KH domain; Region: KH_5; pfam13184 1406863003810 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1406863003811 G-X-X-G motif; other site 1406863003812 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1406863003813 putative RNA binding cleft [nucleotide binding]; other site 1406863003814 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1406863003815 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1406863003816 translation initiation factor IF-2; Region: IF-2; TIGR00487 1406863003817 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1406863003818 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1406863003819 G1 box; other site 1406863003820 putative GEF interaction site [polypeptide binding]; other site 1406863003821 GTP/Mg2+ binding site [chemical binding]; other site 1406863003822 Switch I region; other site 1406863003823 G2 box; other site 1406863003824 G3 box; other site 1406863003825 Switch II region; other site 1406863003826 G4 box; other site 1406863003827 G5 box; other site 1406863003828 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1406863003829 Translation-initiation factor 2; Region: IF-2; pfam11987 1406863003830 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1406863003831 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1406863003832 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1406863003833 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1406863003834 RNA binding site [nucleotide binding]; other site 1406863003835 active site 1406863003836 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1406863003837 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1406863003838 active site 1406863003839 Riboflavin kinase; Region: Flavokinase; smart00904 1406863003840 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1406863003841 16S/18S rRNA binding site [nucleotide binding]; other site 1406863003842 S13e-L30e interaction site [polypeptide binding]; other site 1406863003843 25S rRNA binding site [nucleotide binding]; other site 1406863003844 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1406863003845 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1406863003846 RNase E interface [polypeptide binding]; other site 1406863003847 trimer interface [polypeptide binding]; other site 1406863003848 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1406863003849 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1406863003850 RNase E interface [polypeptide binding]; other site 1406863003851 trimer interface [polypeptide binding]; other site 1406863003852 active site 1406863003853 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1406863003854 putative nucleic acid binding region [nucleotide binding]; other site 1406863003855 G-X-X-G motif; other site 1406863003856 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1406863003857 RNA binding site [nucleotide binding]; other site 1406863003858 domain interface; other site 1406863003859 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1406863003860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1406863003861 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1406863003862 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1406863003863 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1406863003864 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1406863003865 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1406863003866 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1406863003867 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1406863003868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1406863003869 DNA-binding site [nucleotide binding]; DNA binding site 1406863003870 UTRA domain; Region: UTRA; pfam07702 1406863003871 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1406863003872 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1406863003873 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1406863003874 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1406863003875 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1406863003876 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1406863003877 classical (c) SDRs; Region: SDR_c; cd05233 1406863003878 NAD(P) binding site [chemical binding]; other site 1406863003879 active site 1406863003880 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1406863003881 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1406863003882 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1406863003883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863003884 non-specific DNA binding site [nucleotide binding]; other site 1406863003885 salt bridge; other site 1406863003886 sequence-specific DNA binding site [nucleotide binding]; other site 1406863003887 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1406863003888 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1406863003889 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1406863003890 putative MPT binding site; other site 1406863003891 recombinase A; Provisional; Region: recA; PRK09354 1406863003892 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1406863003893 hexamer interface [polypeptide binding]; other site 1406863003894 Walker A motif; other site 1406863003895 ATP binding site [chemical binding]; other site 1406863003896 Walker B motif; other site 1406863003897 phosphodiesterase; Provisional; Region: PRK12704 1406863003898 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1406863003899 Zn2+ binding site [ion binding]; other site 1406863003900 Mg2+ binding site [ion binding]; other site 1406863003901 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1406863003902 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1406863003903 putative active site [active] 1406863003904 metal binding site [ion binding]; metal-binding site 1406863003905 homodimer binding site [polypeptide binding]; other site 1406863003906 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1406863003907 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1406863003908 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1406863003909 dimer interface [polypeptide binding]; other site 1406863003910 PYR/PP interface [polypeptide binding]; other site 1406863003911 TPP binding site [chemical binding]; other site 1406863003912 substrate binding site [chemical binding]; other site 1406863003913 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1406863003914 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1406863003915 TPP-binding site [chemical binding]; other site 1406863003916 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1406863003917 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1406863003918 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1406863003919 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1406863003920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863003921 FeS/SAM binding site; other site 1406863003922 TRAM domain; Region: TRAM; pfam01938 1406863003923 Predicted membrane protein [Function unknown]; Region: COG4550 1406863003924 Predicted membrane protein [Function unknown]; Region: COG4732 1406863003925 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1406863003926 MutS domain I; Region: MutS_I; pfam01624 1406863003927 MutS domain II; Region: MutS_II; pfam05188 1406863003928 MutS domain III; Region: MutS_III; pfam05192 1406863003929 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1406863003930 Walker A/P-loop; other site 1406863003931 ATP binding site [chemical binding]; other site 1406863003932 Q-loop/lid; other site 1406863003933 ABC transporter signature motif; other site 1406863003934 Walker B; other site 1406863003935 D-loop; other site 1406863003936 H-loop/switch region; other site 1406863003937 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1406863003938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863003939 ATP binding site [chemical binding]; other site 1406863003940 Mg2+ binding site [ion binding]; other site 1406863003941 G-X-G motif; other site 1406863003942 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1406863003943 ATP binding site [chemical binding]; other site 1406863003944 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1406863003945 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 1406863003946 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1406863003947 amphipathic channel; other site 1406863003948 Asn-Pro-Ala signature motifs; other site 1406863003949 glycerol kinase; Provisional; Region: glpK; PRK00047 1406863003950 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1406863003951 N- and C-terminal domain interface [polypeptide binding]; other site 1406863003952 active site 1406863003953 MgATP binding site [chemical binding]; other site 1406863003954 catalytic site [active] 1406863003955 metal binding site [ion binding]; metal-binding site 1406863003956 glycerol binding site [chemical binding]; other site 1406863003957 homotetramer interface [polypeptide binding]; other site 1406863003958 homodimer interface [polypeptide binding]; other site 1406863003959 FBP binding site [chemical binding]; other site 1406863003960 protein IIAGlc interface [polypeptide binding]; other site 1406863003961 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1406863003962 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1406863003963 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1406863003964 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 1406863003965 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1406863003966 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1406863003967 bacterial Hfq-like; Region: Hfq; cd01716 1406863003968 hexamer interface [polypeptide binding]; other site 1406863003969 Sm1 motif; other site 1406863003970 RNA binding site [nucleotide binding]; other site 1406863003971 Sm2 motif; other site 1406863003972 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1406863003973 catalytic residues [active] 1406863003974 dimer interface [polypeptide binding]; other site 1406863003975 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1406863003976 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1406863003977 HflX GTPase family; Region: HflX; cd01878 1406863003978 G1 box; other site 1406863003979 GTP/Mg2+ binding site [chemical binding]; other site 1406863003980 Switch I region; other site 1406863003981 G2 box; other site 1406863003982 G3 box; other site 1406863003983 Switch II region; other site 1406863003984 G4 box; other site 1406863003985 G5 box; other site 1406863003986 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1406863003987 Aluminium resistance protein; Region: Alum_res; pfam06838 1406863003988 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1406863003989 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1406863003990 DNA binding residues [nucleotide binding] 1406863003991 putative dimer interface [polypeptide binding]; other site 1406863003992 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1406863003993 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1406863003994 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1406863003995 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863003996 MULE transposase domain; Region: MULE; pfam10551 1406863003997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1406863003998 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1406863003999 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863004000 MULE transposase domain; Region: MULE; pfam10551 1406863004001 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1406863004002 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1406863004003 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1406863004004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1406863004005 catalytic residue [active] 1406863004006 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1406863004007 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1406863004008 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1406863004009 putative active site [active] 1406863004010 catalytic site [active] 1406863004011 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1406863004012 putative active site [active] 1406863004013 catalytic site [active] 1406863004014 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1406863004015 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1406863004016 Walker A/P-loop; other site 1406863004017 ATP binding site [chemical binding]; other site 1406863004018 Q-loop/lid; other site 1406863004019 ABC transporter signature motif; other site 1406863004020 Walker B; other site 1406863004021 D-loop; other site 1406863004022 H-loop/switch region; other site 1406863004023 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1406863004024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1406863004025 Histidine kinase; Region: HisKA_3; pfam07730 1406863004026 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1406863004027 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1406863004028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863004029 active site 1406863004030 phosphorylation site [posttranslational modification] 1406863004031 intermolecular recognition site; other site 1406863004032 dimerization interface [polypeptide binding]; other site 1406863004033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1406863004034 DNA binding residues [nucleotide binding] 1406863004035 dimerization interface [polypeptide binding]; other site 1406863004036 Staphylococcal nuclease homologues; Region: SNc; smart00318 1406863004037 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1406863004038 Catalytic site; other site 1406863004039 AAA domain; Region: AAA_11; pfam13086 1406863004040 aspartate kinase; Reviewed; Region: PRK09034 1406863004041 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1406863004042 putative catalytic residues [active] 1406863004043 putative nucleotide binding site [chemical binding]; other site 1406863004044 putative aspartate binding site [chemical binding]; other site 1406863004045 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1406863004046 allosteric regulatory residue; other site 1406863004047 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1406863004048 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1406863004049 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1406863004050 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1406863004051 threonine synthase; Reviewed; Region: PRK06721 1406863004052 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1406863004053 homodimer interface [polypeptide binding]; other site 1406863004054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863004055 catalytic residue [active] 1406863004056 homoserine kinase; Provisional; Region: PRK01212 1406863004057 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1406863004058 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1406863004059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863004060 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1406863004061 active site 1406863004062 motif I; other site 1406863004063 motif II; other site 1406863004064 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1406863004065 lysine transporter; Provisional; Region: PRK10836 1406863004066 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1406863004067 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1406863004068 tetramer interface [polypeptide binding]; other site 1406863004069 heme binding pocket [chemical binding]; other site 1406863004070 NADPH binding site [chemical binding]; other site 1406863004071 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1406863004072 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1406863004073 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1406863004074 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1406863004075 active site 1406863004076 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1406863004077 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1406863004078 LexA repressor; Validated; Region: PRK00215 1406863004079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1406863004080 putative DNA binding site [nucleotide binding]; other site 1406863004081 putative Zn2+ binding site [ion binding]; other site 1406863004082 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1406863004083 Catalytic site [active] 1406863004084 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1406863004085 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1406863004086 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1406863004087 TPP-binding site [chemical binding]; other site 1406863004088 dimer interface [polypeptide binding]; other site 1406863004089 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1406863004090 PYR/PP interface [polypeptide binding]; other site 1406863004091 dimer interface [polypeptide binding]; other site 1406863004092 TPP binding site [chemical binding]; other site 1406863004093 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1406863004094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1406863004095 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1406863004096 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1406863004097 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1406863004098 active site 1406863004099 metal binding site [ion binding]; metal-binding site 1406863004100 DNA binding site [nucleotide binding] 1406863004101 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1406863004102 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1406863004103 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1406863004104 Walker A/P-loop; other site 1406863004105 ATP binding site [chemical binding]; other site 1406863004106 Q-loop/lid; other site 1406863004107 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1406863004108 ABC transporter signature motif; other site 1406863004109 Walker B; other site 1406863004110 D-loop; other site 1406863004111 H-loop/switch region; other site 1406863004112 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1406863004113 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1406863004114 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1406863004115 aconitate hydratase; Validated; Region: PRK09277 1406863004116 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1406863004117 substrate binding site [chemical binding]; other site 1406863004118 ligand binding site [chemical binding]; other site 1406863004119 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1406863004120 substrate binding site [chemical binding]; other site 1406863004121 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1406863004122 active site 1406863004123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1406863004124 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1406863004125 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1406863004126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863004127 ATP binding site [chemical binding]; other site 1406863004128 Mg2+ binding site [ion binding]; other site 1406863004129 G-X-G motif; other site 1406863004130 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1406863004131 anchoring element; other site 1406863004132 dimer interface [polypeptide binding]; other site 1406863004133 ATP binding site [chemical binding]; other site 1406863004134 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1406863004135 active site 1406863004136 putative metal-binding site [ion binding]; other site 1406863004137 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1406863004138 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1406863004139 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1406863004140 CAP-like domain; other site 1406863004141 active site 1406863004142 primary dimer interface [polypeptide binding]; other site 1406863004143 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1406863004144 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1406863004145 amino acid carrier protein; Region: agcS; TIGR00835 1406863004146 CAT RNA binding domain; Region: CAT_RBD; smart01061 1406863004147 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1406863004148 PRD domain; Region: PRD; pfam00874 1406863004149 PRD domain; Region: PRD; pfam00874 1406863004150 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1406863004151 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1406863004152 Predicted integral membrane protein [Function unknown]; Region: COG0392 1406863004153 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1406863004154 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1406863004155 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1406863004156 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1406863004157 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1406863004158 active site 1 [active] 1406863004159 dimer interface [polypeptide binding]; other site 1406863004160 hexamer interface [polypeptide binding]; other site 1406863004161 active site 2 [active] 1406863004162 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1406863004163 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1406863004164 active site 1406863004165 DNA binding site [nucleotide binding] 1406863004166 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1406863004167 prephenate dehydrogenase; Validated; Region: PRK06545 1406863004168 prephenate dehydrogenase; Validated; Region: PRK08507 1406863004169 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1406863004170 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1406863004171 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1406863004172 putative oligomer interface [polypeptide binding]; other site 1406863004173 putative active site [active] 1406863004174 metal binding site [ion binding]; metal-binding site 1406863004175 anthranilate synthase component I; Provisional; Region: PRK13567 1406863004176 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1406863004177 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1406863004178 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1406863004179 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1406863004180 glutamine binding [chemical binding]; other site 1406863004181 catalytic triad [active] 1406863004182 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1406863004183 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1406863004184 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1406863004185 active site 1406863004186 ribulose/triose binding site [chemical binding]; other site 1406863004187 phosphate binding site [ion binding]; other site 1406863004188 substrate (anthranilate) binding pocket [chemical binding]; other site 1406863004189 product (indole) binding pocket [chemical binding]; other site 1406863004190 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1406863004191 active site 1406863004192 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1406863004193 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1406863004194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863004195 catalytic residue [active] 1406863004196 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1406863004197 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1406863004198 substrate binding site [chemical binding]; other site 1406863004199 active site 1406863004200 catalytic residues [active] 1406863004201 heterodimer interface [polypeptide binding]; other site 1406863004202 FemAB family; Region: FemAB; pfam02388 1406863004203 FlxA-like protein; Region: FlxA; pfam14282 1406863004204 FemAB family; Region: FemAB; pfam02388 1406863004205 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1406863004206 SWIM zinc finger; Region: SWIM; pfam04434 1406863004207 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1406863004208 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863004209 Walker A/P-loop; other site 1406863004210 ATP binding site [chemical binding]; other site 1406863004211 Q-loop/lid; other site 1406863004212 ABC transporter signature motif; other site 1406863004213 Walker B; other site 1406863004214 D-loop; other site 1406863004215 H-loop/switch region; other site 1406863004216 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863004217 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1406863004218 Walker A/P-loop; other site 1406863004219 ATP binding site [chemical binding]; other site 1406863004220 Q-loop/lid; other site 1406863004221 ABC transporter signature motif; other site 1406863004222 Walker B; other site 1406863004223 D-loop; other site 1406863004224 H-loop/switch region; other site 1406863004225 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1406863004226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863004227 dimer interface [polypeptide binding]; other site 1406863004228 conserved gate region; other site 1406863004229 putative PBP binding loops; other site 1406863004230 ABC-ATPase subunit interface; other site 1406863004231 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1406863004232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863004233 dimer interface [polypeptide binding]; other site 1406863004234 conserved gate region; other site 1406863004235 putative PBP binding loops; other site 1406863004236 ABC-ATPase subunit interface; other site 1406863004237 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1406863004238 oligoendopeptidase F; Region: pepF; TIGR00181 1406863004239 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1406863004240 active site 1406863004241 Zn binding site [ion binding]; other site 1406863004242 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1406863004243 PhoU domain; Region: PhoU; pfam01895 1406863004244 PhoU domain; Region: PhoU; pfam01895 1406863004245 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1406863004246 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1406863004247 Walker A/P-loop; other site 1406863004248 ATP binding site [chemical binding]; other site 1406863004249 Q-loop/lid; other site 1406863004250 ABC transporter signature motif; other site 1406863004251 Walker B; other site 1406863004252 D-loop; other site 1406863004253 H-loop/switch region; other site 1406863004254 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1406863004255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863004256 dimer interface [polypeptide binding]; other site 1406863004257 conserved gate region; other site 1406863004258 putative PBP binding loops; other site 1406863004259 ABC-ATPase subunit interface; other site 1406863004260 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1406863004261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863004262 dimer interface [polypeptide binding]; other site 1406863004263 conserved gate region; other site 1406863004264 ABC-ATPase subunit interface; other site 1406863004265 phosphate binding protein; Region: ptsS_2; TIGR02136 1406863004266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1406863004267 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1406863004268 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1406863004269 S1 domain; Region: S1_2; pfam13509 1406863004270 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1406863004271 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1406863004272 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1406863004273 ABC transporter; Region: ABC_tran_2; pfam12848 1406863004274 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1406863004275 aspartate kinase; Reviewed; Region: PRK06635 1406863004276 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1406863004277 putative nucleotide binding site [chemical binding]; other site 1406863004278 putative catalytic residues [active] 1406863004279 putative Mg ion binding site [ion binding]; other site 1406863004280 putative aspartate binding site [chemical binding]; other site 1406863004281 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1406863004282 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1406863004283 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1406863004284 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1406863004285 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1406863004286 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1406863004287 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1406863004288 dimer interface [polypeptide binding]; other site 1406863004289 active site 1406863004290 catalytic residue [active] 1406863004291 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1406863004292 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1406863004293 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1406863004294 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1406863004295 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1406863004296 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1406863004297 active site 1406863004298 trimer interface [polypeptide binding]; other site 1406863004299 substrate binding site [chemical binding]; other site 1406863004300 CoA binding site [chemical binding]; other site 1406863004301 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1406863004302 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1406863004303 metal binding site [ion binding]; metal-binding site 1406863004304 dimer interface [polypeptide binding]; other site 1406863004305 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1406863004306 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1406863004307 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1406863004308 catalytic residue [active] 1406863004309 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1406863004310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1406863004311 active site 1406863004312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1406863004313 substrate binding site [chemical binding]; other site 1406863004314 catalytic residues [active] 1406863004315 dimer interface [polypeptide binding]; other site 1406863004316 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1406863004317 DNA-binding site [nucleotide binding]; DNA binding site 1406863004318 RNA-binding motif; other site 1406863004319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1406863004320 acylphosphatase; Provisional; Region: PRK14431 1406863004321 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1406863004322 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1406863004323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1406863004324 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1406863004325 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1406863004326 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1406863004327 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1406863004328 metal ion-dependent adhesion site (MIDAS); other site 1406863004329 MoxR-like ATPases [General function prediction only]; Region: COG0714 1406863004330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863004331 Walker A motif; other site 1406863004332 ATP binding site [chemical binding]; other site 1406863004333 Walker B motif; other site 1406863004334 arginine finger; other site 1406863004335 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1406863004336 active site 1406863004337 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1406863004338 active site 1406863004339 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1406863004340 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1406863004341 E3 interaction surface; other site 1406863004342 lipoyl attachment site [posttranslational modification]; other site 1406863004343 e3 binding domain; Region: E3_binding; pfam02817 1406863004344 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1406863004345 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1406863004346 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1406863004347 TPP-binding site [chemical binding]; other site 1406863004348 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1406863004349 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1406863004350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1406863004351 HAMP domain; Region: HAMP; pfam00672 1406863004352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1406863004353 dimer interface [polypeptide binding]; other site 1406863004354 phosphorylation site [posttranslational modification] 1406863004355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863004356 ATP binding site [chemical binding]; other site 1406863004357 Mg2+ binding site [ion binding]; other site 1406863004358 G-X-G motif; other site 1406863004359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1406863004360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863004361 active site 1406863004362 phosphorylation site [posttranslational modification] 1406863004363 intermolecular recognition site; other site 1406863004364 dimerization interface [polypeptide binding]; other site 1406863004365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1406863004366 DNA binding site [nucleotide binding] 1406863004367 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1406863004368 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1406863004369 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1406863004370 active site 1406863004371 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1406863004372 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1406863004373 active site 1406863004374 homodimer interface [polypeptide binding]; other site 1406863004375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863004376 Coenzyme A binding pocket [chemical binding]; other site 1406863004377 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1406863004378 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1406863004379 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1406863004380 protein binding site [polypeptide binding]; other site 1406863004381 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1406863004382 Catalytic dyad [active] 1406863004383 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1406863004384 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 1406863004385 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1406863004386 HPr interaction site; other site 1406863004387 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1406863004388 active site 1406863004389 phosphorylation site [posttranslational modification] 1406863004390 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1406863004391 SelR domain; Region: SelR; pfam01641 1406863004392 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1406863004393 EDD domain protein, DegV family; Region: DegV; TIGR00762 1406863004394 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1406863004395 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1406863004396 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1406863004397 folate binding site [chemical binding]; other site 1406863004398 NADP+ binding site [chemical binding]; other site 1406863004399 thymidylate synthase; Region: thym_sym; TIGR03284 1406863004400 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1406863004401 dimerization interface [polypeptide binding]; other site 1406863004402 active site 1406863004403 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1406863004404 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1406863004405 Virulence factor; Region: Virulence_fact; pfam13769 1406863004406 HEAT repeats; Region: HEAT_2; pfam13646 1406863004407 HEAT repeat; Region: HEAT; pfam02985 1406863004408 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1406863004409 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1406863004410 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1406863004411 RNA/DNA hybrid binding site [nucleotide binding]; other site 1406863004412 active site 1406863004413 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863004414 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1406863004415 GA module; Region: GA; smart00844 1406863004416 GA module; Region: GA; smart00844 1406863004417 GA module; Region: GA; smart00844 1406863004418 GA module; Region: GA; smart00844 1406863004419 GA module; Region: GA; smart00844 1406863004420 GA module; Region: GA; smart00844 1406863004421 GA module; Region: GA; smart00844 1406863004422 GA module; Region: GA; smart00844 1406863004423 GA module; Region: GA; smart00844 1406863004424 GA module; Region: GA; smart00844 1406863004425 GA module; Region: GA; smart00844 1406863004426 GA module; Region: GA; smart00844 1406863004427 GA module; Region: GA; smart00844 1406863004428 GA module; Region: GA; smart00844 1406863004429 GA module; Region: GA; smart00844 1406863004430 GA module; Region: GA; smart00844 1406863004431 GA module; Region: GA; smart00844 1406863004432 GA module; Region: GA; smart00844 1406863004433 GA module; Region: GA; smart00844 1406863004434 GA module; Region: GA; pfam01468 1406863004435 GA module; Region: GA; smart00844 1406863004436 GA module; Region: GA; smart00844 1406863004437 GA module; Region: GA; smart00844 1406863004438 GA module; Region: GA; smart00844 1406863004439 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1406863004440 GA module; Region: GA; smart00844 1406863004441 GA module; Region: GA; smart00844 1406863004442 GA module; Region: GA; smart00844 1406863004443 GA module; Region: GA; smart00844 1406863004444 GA module; Region: GA; smart00844 1406863004445 GA module; Region: GA; smart00844 1406863004446 GA module; Region: GA; smart00844 1406863004447 GA module; Region: GA; pfam01468 1406863004448 GA module; Region: GA; smart00844 1406863004449 GA module; Region: GA; smart00844 1406863004450 GA module; Region: GA; smart00844 1406863004451 GA module; Region: GA; smart00844 1406863004452 GA module; Region: GA; smart00844 1406863004453 GA module; Region: GA; smart00844 1406863004454 GA module; Region: GA; smart00844 1406863004455 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1406863004456 GA module; Region: GA; smart00844 1406863004457 GA module; Region: GA; smart00844 1406863004458 GA module; Region: GA; smart00844 1406863004459 GA module; Region: GA; smart00844 1406863004460 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863004461 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863004462 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1406863004463 Amino acid permease; Region: AA_permease_2; pfam13520 1406863004464 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1406863004465 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1406863004466 tetramer interface [polypeptide binding]; other site 1406863004467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863004468 catalytic residue [active] 1406863004469 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1406863004470 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1406863004471 hexamer interface [polypeptide binding]; other site 1406863004472 ligand binding site [chemical binding]; other site 1406863004473 putative active site [active] 1406863004474 NAD(P) binding site [chemical binding]; other site 1406863004475 5'-3' exonuclease; Region: 53EXOc; smart00475 1406863004476 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1406863004477 active site 1406863004478 metal binding site 1 [ion binding]; metal-binding site 1406863004479 putative 5' ssDNA interaction site; other site 1406863004480 metal binding site 3; metal-binding site 1406863004481 metal binding site 2 [ion binding]; metal-binding site 1406863004482 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1406863004483 putative DNA binding site [nucleotide binding]; other site 1406863004484 putative metal binding site [ion binding]; other site 1406863004485 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1406863004486 Dynamin family; Region: Dynamin_N; pfam00350 1406863004487 G1 box; other site 1406863004488 GTP/Mg2+ binding site [chemical binding]; other site 1406863004489 G2 box; other site 1406863004490 Switch I region; other site 1406863004491 G3 box; other site 1406863004492 Switch II region; other site 1406863004493 G4 box; other site 1406863004494 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1406863004495 Dynamin family; Region: Dynamin_N; pfam00350 1406863004496 G1 box; other site 1406863004497 GTP/Mg2+ binding site [chemical binding]; other site 1406863004498 G2 box; other site 1406863004499 Switch I region; other site 1406863004500 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1406863004501 G3 box; other site 1406863004502 Switch II region; other site 1406863004503 GTP/Mg2+ binding site [chemical binding]; other site 1406863004504 G4 box; other site 1406863004505 G5 box; other site 1406863004506 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1406863004507 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1406863004508 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1406863004509 Cobalt transport protein component CbiN; Region: CbiN; cl00842 1406863004510 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1406863004511 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1406863004512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1406863004513 cell division protein GpsB; Provisional; Region: PRK14127 1406863004514 DivIVA domain; Region: DivI1A_domain; TIGR03544 1406863004515 hypothetical protein; Provisional; Region: PRK13660 1406863004516 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1406863004517 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1406863004518 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1406863004519 Transglycosylase; Region: Transgly; pfam00912 1406863004520 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1406863004521 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1406863004522 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1406863004523 minor groove reading motif; other site 1406863004524 helix-hairpin-helix signature motif; other site 1406863004525 substrate binding pocket [chemical binding]; other site 1406863004526 active site 1406863004527 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1406863004528 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1406863004529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1406863004530 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1406863004531 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1406863004532 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1406863004533 putative dimer interface [polypeptide binding]; other site 1406863004534 putative anticodon binding site; other site 1406863004535 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1406863004536 homodimer interface [polypeptide binding]; other site 1406863004537 motif 1; other site 1406863004538 motif 2; other site 1406863004539 active site 1406863004540 motif 3; other site 1406863004541 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1406863004542 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1406863004543 active site 1406863004544 catalytic site [active] 1406863004545 substrate binding site [chemical binding]; other site 1406863004546 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1406863004547 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1406863004548 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1406863004549 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1406863004550 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1406863004551 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1406863004552 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1406863004553 active site 1406863004554 NTP binding site [chemical binding]; other site 1406863004555 metal binding triad [ion binding]; metal-binding site 1406863004556 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1406863004557 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1406863004558 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1406863004559 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1406863004560 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1406863004561 homodimer interface [polypeptide binding]; other site 1406863004562 metal binding site [ion binding]; metal-binding site 1406863004563 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1406863004564 Predicted membrane protein [Function unknown]; Region: COG4347 1406863004565 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1406863004566 UPF0302 domain; Region: UPF0302; pfam08864 1406863004567 A short protein domain of unknown function; Region: IDEAL; smart00914 1406863004568 TPR repeat; Region: TPR_11; pfam13414 1406863004569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1406863004570 binding surface 1406863004571 TPR motif; other site 1406863004572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1406863004573 TPR motif; other site 1406863004574 binding surface 1406863004575 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1406863004576 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1406863004577 hinge; other site 1406863004578 active site 1406863004579 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1406863004580 active site 1406863004581 NAD binding site [chemical binding]; other site 1406863004582 metal binding site [ion binding]; metal-binding site 1406863004583 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1406863004584 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1406863004585 Tetramer interface [polypeptide binding]; other site 1406863004586 active site 1406863004587 FMN-binding site [chemical binding]; other site 1406863004588 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1406863004589 active site 1406863004590 multimer interface [polypeptide binding]; other site 1406863004591 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1406863004592 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1406863004593 substrate binding pocket [chemical binding]; other site 1406863004594 chain length determination region; other site 1406863004595 substrate-Mg2+ binding site; other site 1406863004596 catalytic residues [active] 1406863004597 aspartate-rich region 1; other site 1406863004598 active site lid residues [active] 1406863004599 aspartate-rich region 2; other site 1406863004600 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1406863004601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863004602 S-adenosylmethionine binding site [chemical binding]; other site 1406863004603 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1406863004604 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1406863004605 IHF dimer interface [polypeptide binding]; other site 1406863004606 IHF - DNA interface [nucleotide binding]; other site 1406863004607 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1406863004608 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1406863004609 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1406863004610 GTP-binding protein Der; Reviewed; Region: PRK00093 1406863004611 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1406863004612 G1 box; other site 1406863004613 GTP/Mg2+ binding site [chemical binding]; other site 1406863004614 Switch I region; other site 1406863004615 G2 box; other site 1406863004616 Switch II region; other site 1406863004617 G3 box; other site 1406863004618 G4 box; other site 1406863004619 G5 box; other site 1406863004620 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1406863004621 G1 box; other site 1406863004622 GTP/Mg2+ binding site [chemical binding]; other site 1406863004623 Switch I region; other site 1406863004624 G2 box; other site 1406863004625 G3 box; other site 1406863004626 Switch II region; other site 1406863004627 G4 box; other site 1406863004628 G5 box; other site 1406863004629 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1406863004630 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1406863004631 RNA binding site [nucleotide binding]; other site 1406863004632 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1406863004633 RNA binding site [nucleotide binding]; other site 1406863004634 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1406863004635 RNA binding site [nucleotide binding]; other site 1406863004636 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1406863004637 RNA binding site [nucleotide binding]; other site 1406863004638 cytidylate kinase; Provisional; Region: cmk; PRK00023 1406863004639 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1406863004640 CMP-binding site; other site 1406863004641 The sites determining sugar specificity; other site 1406863004642 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1406863004643 active site 1406863004644 homotetramer interface [polypeptide binding]; other site 1406863004645 homodimer interface [polypeptide binding]; other site 1406863004646 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1406863004647 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1406863004648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863004649 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1406863004650 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1406863004651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863004652 ATP binding site [chemical binding]; other site 1406863004653 putative Mg++ binding site [ion binding]; other site 1406863004654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1406863004655 nucleotide binding region [chemical binding]; other site 1406863004656 ATP-binding site [chemical binding]; other site 1406863004657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1406863004658 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1406863004659 Predicted membrane protein [Function unknown]; Region: COG3601 1406863004660 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1406863004661 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1406863004662 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1406863004663 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1406863004664 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1406863004665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1406863004666 dimerization interface [polypeptide binding]; other site 1406863004667 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1406863004668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1406863004669 dimer interface [polypeptide binding]; other site 1406863004670 phosphorylation site [posttranslational modification] 1406863004671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863004672 ATP binding site [chemical binding]; other site 1406863004673 Mg2+ binding site [ion binding]; other site 1406863004674 G-X-G motif; other site 1406863004675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1406863004676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863004677 active site 1406863004678 phosphorylation site [posttranslational modification] 1406863004679 intermolecular recognition site; other site 1406863004680 dimerization interface [polypeptide binding]; other site 1406863004681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1406863004682 DNA binding site [nucleotide binding] 1406863004683 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1406863004684 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1406863004685 RNA binding surface [nucleotide binding]; other site 1406863004686 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1406863004687 active site 1406863004688 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1406863004689 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1406863004690 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1406863004691 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1406863004692 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1406863004693 active site 1406863004694 Int/Topo IB signature motif; other site 1406863004695 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1406863004696 metal binding site 2 [ion binding]; metal-binding site 1406863004697 putative DNA binding helix; other site 1406863004698 metal binding site 1 [ion binding]; metal-binding site 1406863004699 dimer interface [polypeptide binding]; other site 1406863004700 structural Zn2+ binding site [ion binding]; other site 1406863004701 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1406863004702 dimer interface [polypeptide binding]; other site 1406863004703 ADP-ribose binding site [chemical binding]; other site 1406863004704 active site 1406863004705 nudix motif; other site 1406863004706 metal binding site [ion binding]; metal-binding site 1406863004707 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1406863004708 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1406863004709 active site 1406863004710 catalytic tetrad [active] 1406863004711 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1406863004712 classical (c) SDRs; Region: SDR_c; cd05233 1406863004713 NAD(P) binding site [chemical binding]; other site 1406863004714 active site 1406863004715 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1406863004716 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1406863004717 ribonuclease Z; Region: RNase_Z; TIGR02651 1406863004718 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1406863004719 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1406863004720 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1406863004721 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1406863004722 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1406863004723 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1406863004724 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1406863004725 Ca binding site [ion binding]; other site 1406863004726 active site 1406863004727 catalytic site [active] 1406863004728 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1406863004729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1406863004730 DNA binding site [nucleotide binding] 1406863004731 domain linker motif; other site 1406863004732 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1406863004733 putative ligand binding site [chemical binding]; other site 1406863004734 putative dimerization interface [polypeptide binding]; other site 1406863004735 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1406863004736 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1406863004737 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1406863004738 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1406863004739 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1406863004740 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1406863004741 peptidase T-like protein; Region: PepT-like; TIGR01883 1406863004742 metal binding site [ion binding]; metal-binding site 1406863004743 putative dimer interface [polypeptide binding]; other site 1406863004744 Predicted membrane protein [Function unknown]; Region: COG4129 1406863004745 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1406863004746 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1406863004747 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1406863004748 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1406863004749 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1406863004750 E3 interaction surface; other site 1406863004751 lipoyl attachment site [posttranslational modification]; other site 1406863004752 e3 binding domain; Region: E3_binding; pfam02817 1406863004753 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1406863004754 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1406863004755 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1406863004756 alpha subunit interface [polypeptide binding]; other site 1406863004757 TPP binding site [chemical binding]; other site 1406863004758 heterodimer interface [polypeptide binding]; other site 1406863004759 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1406863004760 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1406863004761 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1406863004762 tetramer interface [polypeptide binding]; other site 1406863004763 TPP-binding site [chemical binding]; other site 1406863004764 heterodimer interface [polypeptide binding]; other site 1406863004765 phosphorylation loop region [posttranslational modification] 1406863004766 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1406863004767 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1406863004768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863004769 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1406863004770 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1406863004771 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1406863004772 Walker A/P-loop; other site 1406863004773 ATP binding site [chemical binding]; other site 1406863004774 Q-loop/lid; other site 1406863004775 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1406863004776 ABC transporter signature motif; other site 1406863004777 Walker B; other site 1406863004778 D-loop; other site 1406863004779 H-loop/switch region; other site 1406863004780 arginine repressor; Provisional; Region: PRK04280 1406863004781 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1406863004782 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1406863004783 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1406863004784 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1406863004785 substrate binding pocket [chemical binding]; other site 1406863004786 chain length determination region; other site 1406863004787 substrate-Mg2+ binding site; other site 1406863004788 catalytic residues [active] 1406863004789 aspartate-rich region 1; other site 1406863004790 active site lid residues [active] 1406863004791 aspartate-rich region 2; other site 1406863004792 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1406863004793 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1406863004794 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1406863004795 generic binding surface II; other site 1406863004796 generic binding surface I; other site 1406863004797 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1406863004798 putative RNA binding site [nucleotide binding]; other site 1406863004799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1406863004800 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1406863004801 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1406863004802 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1406863004803 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1406863004804 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1406863004805 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1406863004806 carboxyltransferase (CT) interaction site; other site 1406863004807 biotinylation site [posttranslational modification]; other site 1406863004808 elongation factor P; Validated; Region: PRK00529 1406863004809 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1406863004810 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1406863004811 RNA binding site [nucleotide binding]; other site 1406863004812 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1406863004813 RNA binding site [nucleotide binding]; other site 1406863004814 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1406863004815 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1406863004816 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1406863004817 active site 1406863004818 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1406863004819 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1406863004820 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1406863004821 active site residue [active] 1406863004822 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1406863004823 tetramer interface [polypeptide binding]; other site 1406863004824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863004825 catalytic residue [active] 1406863004826 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1406863004827 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1406863004828 tetramer interface [polypeptide binding]; other site 1406863004829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863004830 catalytic residue [active] 1406863004831 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1406863004832 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1406863004833 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1406863004834 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1406863004835 ADP binding site [chemical binding]; other site 1406863004836 magnesium binding site [ion binding]; other site 1406863004837 putative shikimate binding site; other site 1406863004838 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1406863004839 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1406863004840 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1406863004841 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1406863004842 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1406863004843 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1406863004844 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1406863004845 Type II/IV secretion system protein; Region: T2SE; pfam00437 1406863004846 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1406863004847 Walker A motif; other site 1406863004848 ATP binding site [chemical binding]; other site 1406863004849 Walker B motif; other site 1406863004850 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1406863004851 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1406863004852 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1406863004853 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1406863004854 Rhomboid family; Region: Rhomboid; pfam01694 1406863004855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1406863004856 binding surface 1406863004857 TPR motif; other site 1406863004858 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1406863004859 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1406863004860 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1406863004861 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1406863004862 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1406863004863 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1406863004864 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1406863004865 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1406863004866 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1406863004867 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1406863004868 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1406863004869 metal binding site 2 [ion binding]; metal-binding site 1406863004870 putative DNA binding helix; other site 1406863004871 metal binding site 1 [ion binding]; metal-binding site 1406863004872 dimer interface [polypeptide binding]; other site 1406863004873 structural Zn2+ binding site [ion binding]; other site 1406863004874 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1406863004875 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863004876 ABC-ATPase subunit interface; other site 1406863004877 dimer interface [polypeptide binding]; other site 1406863004878 putative PBP binding regions; other site 1406863004879 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1406863004880 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1406863004881 endonuclease IV; Provisional; Region: PRK01060 1406863004882 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1406863004883 AP (apurinic/apyrimidinic) site pocket; other site 1406863004884 DNA interaction; other site 1406863004885 Metal-binding active site; metal-binding site 1406863004886 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1406863004887 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1406863004888 ATP binding site [chemical binding]; other site 1406863004889 Mg++ binding site [ion binding]; other site 1406863004890 motif III; other site 1406863004891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1406863004892 nucleotide binding region [chemical binding]; other site 1406863004893 ATP-binding site [chemical binding]; other site 1406863004894 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1406863004895 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1406863004896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1406863004897 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1406863004898 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1406863004899 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1406863004900 Family of unknown function (DUF633); Region: DUF633; pfam04816 1406863004901 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1406863004902 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1406863004903 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1406863004904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1406863004905 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1406863004906 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1406863004907 DNA binding residues [nucleotide binding] 1406863004908 DNA primase, catalytic core; Region: dnaG; TIGR01391 1406863004909 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1406863004910 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1406863004911 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1406863004912 active site 1406863004913 metal binding site [ion binding]; metal-binding site 1406863004914 interdomain interaction site; other site 1406863004915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1406863004916 HTH domain; Region: HTH_11; cl17392 1406863004917 FOG: CBS domain [General function prediction only]; Region: COG0517 1406863004918 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1406863004919 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1406863004920 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1406863004921 motif 1; other site 1406863004922 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1406863004923 active site 1406863004924 motif 2; other site 1406863004925 motif 3; other site 1406863004926 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1406863004927 anticodon binding site; other site 1406863004928 DNA repair protein RecO; Region: reco; TIGR00613 1406863004929 Recombination protein O N terminal; Region: RecO_N; pfam11967 1406863004930 Recombination protein O C terminal; Region: RecO_C; pfam02565 1406863004931 GTPase Era; Reviewed; Region: era; PRK00089 1406863004932 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1406863004933 G1 box; other site 1406863004934 GTP/Mg2+ binding site [chemical binding]; other site 1406863004935 Switch I region; other site 1406863004936 G2 box; other site 1406863004937 Switch II region; other site 1406863004938 G3 box; other site 1406863004939 G4 box; other site 1406863004940 G5 box; other site 1406863004941 KH domain; Region: KH_2; pfam07650 1406863004942 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1406863004943 active site 1406863004944 catalytic motif [active] 1406863004945 Zn binding site [ion binding]; other site 1406863004946 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1406863004947 metal-binding heat shock protein; Provisional; Region: PRK00016 1406863004948 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1406863004949 PhoH-like protein; Region: PhoH; pfam02562 1406863004950 hypothetical protein; Provisional; Region: PRK13665 1406863004951 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1406863004952 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1406863004953 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1406863004954 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1406863004955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863004956 FeS/SAM binding site; other site 1406863004957 TRAM domain; Region: TRAM; cl01282 1406863004958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1406863004959 RNA methyltransferase, RsmE family; Region: TIGR00046 1406863004960 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1406863004961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863004962 S-adenosylmethionine binding site [chemical binding]; other site 1406863004963 chaperone protein DnaJ; Provisional; Region: PRK14280 1406863004964 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1406863004965 HSP70 interaction site [polypeptide binding]; other site 1406863004966 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1406863004967 substrate binding site [polypeptide binding]; other site 1406863004968 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1406863004969 Zn binding sites [ion binding]; other site 1406863004970 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1406863004971 dimer interface [polypeptide binding]; other site 1406863004972 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1406863004973 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1406863004974 nucleotide binding site [chemical binding]; other site 1406863004975 NEF interaction site [polypeptide binding]; other site 1406863004976 SBD interface [polypeptide binding]; other site 1406863004977 heat shock protein GrpE; Provisional; Region: PRK14140 1406863004978 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1406863004979 dimer interface [polypeptide binding]; other site 1406863004980 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1406863004981 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1406863004982 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1406863004983 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 1406863004984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863004985 FeS/SAM binding site; other site 1406863004986 HemN C-terminal domain; Region: HemN_C; pfam06969 1406863004987 GTP-binding protein LepA; Provisional; Region: PRK05433 1406863004988 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1406863004989 G1 box; other site 1406863004990 putative GEF interaction site [polypeptide binding]; other site 1406863004991 GTP/Mg2+ binding site [chemical binding]; other site 1406863004992 Switch I region; other site 1406863004993 G2 box; other site 1406863004994 G3 box; other site 1406863004995 Switch II region; other site 1406863004996 G4 box; other site 1406863004997 G5 box; other site 1406863004998 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1406863004999 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1406863005000 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1406863005001 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1406863005002 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1406863005003 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1406863005004 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1406863005005 Competence protein; Region: Competence; pfam03772 1406863005006 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1406863005007 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1406863005008 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1406863005009 catalytic motif [active] 1406863005010 Zn binding site [ion binding]; other site 1406863005011 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1406863005012 SLBB domain; Region: SLBB; pfam10531 1406863005013 Helix-hairpin-helix motif; Region: HHH; pfam00633 1406863005014 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1406863005015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863005016 S-adenosylmethionine binding site [chemical binding]; other site 1406863005017 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1406863005018 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1406863005019 Zn2+ binding site [ion binding]; other site 1406863005020 Mg2+ binding site [ion binding]; other site 1406863005021 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1406863005022 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1406863005023 active site 1406863005024 (T/H)XGH motif; other site 1406863005025 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1406863005026 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1406863005027 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1406863005028 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1406863005029 shikimate binding site; other site 1406863005030 NAD(P) binding site [chemical binding]; other site 1406863005031 GTPase YqeH; Provisional; Region: PRK13796 1406863005032 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1406863005033 GTP/Mg2+ binding site [chemical binding]; other site 1406863005034 G4 box; other site 1406863005035 G5 box; other site 1406863005036 G1 box; other site 1406863005037 Switch I region; other site 1406863005038 G2 box; other site 1406863005039 G3 box; other site 1406863005040 Switch II region; other site 1406863005041 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1406863005042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863005043 active site 1406863005044 motif I; other site 1406863005045 motif II; other site 1406863005046 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1406863005047 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1406863005048 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1406863005049 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863005050 Fic family protein [Function unknown]; Region: COG3177 1406863005051 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863005052 MULE transposase domain; Region: MULE; pfam10551 1406863005053 Fic family protein [Function unknown]; Region: COG3177 1406863005054 Fic/DOC family; Region: Fic; pfam02661 1406863005055 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1406863005056 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1406863005057 putative active site [active] 1406863005058 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1406863005059 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1406863005060 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1406863005061 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1406863005062 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1406863005063 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1406863005064 carboxyltransferase (CT) interaction site; other site 1406863005065 biotinylation site [posttranslational modification]; other site 1406863005066 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1406863005067 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1406863005068 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1406863005069 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1406863005070 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1406863005071 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1406863005072 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1406863005073 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1406863005074 Sugar specificity; other site 1406863005075 Pyrimidine base specificity; other site 1406863005076 ATP-binding site [chemical binding]; other site 1406863005077 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1406863005078 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1406863005079 Peptidase family U32; Region: Peptidase_U32; pfam01136 1406863005080 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1406863005081 Peptidase family U32; Region: Peptidase_U32; pfam01136 1406863005082 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1406863005083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863005084 S-adenosylmethionine binding site [chemical binding]; other site 1406863005085 hypothetical protein; Provisional; Region: PRK13678 1406863005086 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1406863005087 hypothetical protein; Provisional; Region: PRK05473 1406863005088 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1406863005089 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1406863005090 motif 1; other site 1406863005091 active site 1406863005092 motif 2; other site 1406863005093 motif 3; other site 1406863005094 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1406863005095 DHHA1 domain; Region: DHHA1; pfam02272 1406863005096 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1406863005097 AAA domain; Region: AAA_30; pfam13604 1406863005098 Family description; Region: UvrD_C_2; pfam13538 1406863005099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1406863005100 binding surface 1406863005101 TPR motif; other site 1406863005102 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1406863005103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1406863005104 binding surface 1406863005105 TPR motif; other site 1406863005106 TPR repeat; Region: TPR_11; pfam13414 1406863005107 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1406863005108 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1406863005109 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1406863005110 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1406863005111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1406863005112 catalytic residue [active] 1406863005113 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1406863005114 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1406863005115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1406863005116 Predicted transcriptional regulator [Transcription]; Region: COG1959 1406863005117 Transcriptional regulator; Region: Rrf2; pfam02082 1406863005118 recombination factor protein RarA; Reviewed; Region: PRK13342 1406863005119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863005120 Walker A motif; other site 1406863005121 ATP binding site [chemical binding]; other site 1406863005122 Walker B motif; other site 1406863005123 arginine finger; other site 1406863005124 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1406863005125 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1406863005126 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1406863005127 putative ATP binding site [chemical binding]; other site 1406863005128 putative substrate interface [chemical binding]; other site 1406863005129 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1406863005130 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1406863005131 dimer interface [polypeptide binding]; other site 1406863005132 anticodon binding site; other site 1406863005133 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1406863005134 homodimer interface [polypeptide binding]; other site 1406863005135 motif 1; other site 1406863005136 active site 1406863005137 motif 2; other site 1406863005138 GAD domain; Region: GAD; pfam02938 1406863005139 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1406863005140 motif 3; other site 1406863005141 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1406863005142 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1406863005143 dimer interface [polypeptide binding]; other site 1406863005144 motif 1; other site 1406863005145 active site 1406863005146 motif 2; other site 1406863005147 motif 3; other site 1406863005148 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1406863005149 anticodon binding site; other site 1406863005150 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1406863005151 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1406863005152 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1406863005153 active site 1406863005154 metal binding site [ion binding]; metal-binding site 1406863005155 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1406863005156 putative active site [active] 1406863005157 dimerization interface [polypeptide binding]; other site 1406863005158 putative tRNAtyr binding site [nucleotide binding]; other site 1406863005159 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1406863005160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1406863005161 Zn2+ binding site [ion binding]; other site 1406863005162 Mg2+ binding site [ion binding]; other site 1406863005163 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1406863005164 synthetase active site [active] 1406863005165 NTP binding site [chemical binding]; other site 1406863005166 metal binding site [ion binding]; metal-binding site 1406863005167 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1406863005168 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1406863005169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1406863005170 active site 1406863005171 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1406863005172 DHH family; Region: DHH; pfam01368 1406863005173 DHHA1 domain; Region: DHHA1; pfam02272 1406863005174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1406863005175 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1406863005176 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1406863005177 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1406863005178 Protein export membrane protein; Region: SecD_SecF; pfam02355 1406863005179 Preprotein translocase subunit; Region: YajC; pfam02699 1406863005180 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1406863005181 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1406863005182 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1406863005183 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1406863005184 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1406863005185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863005186 Walker A motif; other site 1406863005187 ATP binding site [chemical binding]; other site 1406863005188 Walker B motif; other site 1406863005189 arginine finger; other site 1406863005190 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1406863005191 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1406863005192 RuvA N terminal domain; Region: RuvA_N; pfam01330 1406863005193 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1406863005194 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 1406863005195 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1406863005196 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1406863005197 GTP1/OBG; Region: GTP1_OBG; pfam01018 1406863005198 Obg GTPase; Region: Obg; cd01898 1406863005199 G1 box; other site 1406863005200 GTP/Mg2+ binding site [chemical binding]; other site 1406863005201 Switch I region; other site 1406863005202 G2 box; other site 1406863005203 G3 box; other site 1406863005204 Switch II region; other site 1406863005205 G4 box; other site 1406863005206 G5 box; other site 1406863005207 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1406863005208 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1406863005209 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1406863005210 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1406863005211 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1406863005212 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1406863005213 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1406863005214 rod shape-determining protein MreC; Region: MreC; pfam04085 1406863005215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863005216 S-adenosylmethionine binding site [chemical binding]; other site 1406863005217 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1406863005218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863005219 S-adenosylmethionine binding site [chemical binding]; other site 1406863005220 aminoglycoside resistance protein; Provisional; Region: PRK13746 1406863005221 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1406863005222 active site 1406863005223 NTP binding site [chemical binding]; other site 1406863005224 metal binding triad [ion binding]; metal-binding site 1406863005225 antibiotic binding site [chemical binding]; other site 1406863005226 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1406863005227 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1406863005228 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1406863005229 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 1406863005230 Int/Topo IB signature motif; other site 1406863005231 hypothetical protein; Reviewed; Region: PRK00024 1406863005232 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1406863005233 MPN+ (JAMM) motif; other site 1406863005234 Zinc-binding site [ion binding]; other site 1406863005235 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1406863005236 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1406863005237 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1406863005238 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1406863005239 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1406863005240 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1406863005241 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1406863005242 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1406863005243 active site 1406863005244 HIGH motif; other site 1406863005245 nucleotide binding site [chemical binding]; other site 1406863005246 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1406863005247 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1406863005248 active site 1406863005249 KMSKS motif; other site 1406863005250 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1406863005251 tRNA binding surface [nucleotide binding]; other site 1406863005252 anticodon binding site; other site 1406863005253 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1406863005254 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1406863005255 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1406863005256 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1406863005257 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1406863005258 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1406863005259 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1406863005260 inhibitor-cofactor binding pocket; inhibition site 1406863005261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863005262 catalytic residue [active] 1406863005263 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1406863005264 dimer interface [polypeptide binding]; other site 1406863005265 active site 1406863005266 Schiff base residues; other site 1406863005267 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1406863005268 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1406863005269 active site 1406863005270 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1406863005271 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1406863005272 domain interfaces; other site 1406863005273 active site 1406863005274 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 1406863005275 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1406863005276 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1406863005277 tRNA; other site 1406863005278 putative tRNA binding site [nucleotide binding]; other site 1406863005279 putative NADP binding site [chemical binding]; other site 1406863005280 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1406863005281 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1406863005282 G1 box; other site 1406863005283 GTP/Mg2+ binding site [chemical binding]; other site 1406863005284 Switch I region; other site 1406863005285 G2 box; other site 1406863005286 G3 box; other site 1406863005287 Switch II region; other site 1406863005288 G4 box; other site 1406863005289 G5 box; other site 1406863005290 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1406863005291 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1406863005292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863005293 Walker A motif; other site 1406863005294 ATP binding site [chemical binding]; other site 1406863005295 Walker B motif; other site 1406863005296 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1406863005297 trigger factor; Provisional; Region: tig; PRK01490 1406863005298 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1406863005299 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1406863005300 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1406863005301 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1406863005302 23S rRNA binding site [nucleotide binding]; other site 1406863005303 L21 binding site [polypeptide binding]; other site 1406863005304 L13 binding site [polypeptide binding]; other site 1406863005305 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1406863005306 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1406863005307 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1406863005308 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1406863005309 lysine transporter; Provisional; Region: PRK10836 1406863005310 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1406863005311 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1406863005312 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1406863005313 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1406863005314 active site 1406863005315 dimer interface [polypeptide binding]; other site 1406863005316 motif 1; other site 1406863005317 motif 2; other site 1406863005318 motif 3; other site 1406863005319 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1406863005320 anticodon binding site; other site 1406863005321 primosomal protein DnaI; Reviewed; Region: PRK08939 1406863005322 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1406863005323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863005324 Walker A motif; other site 1406863005325 ATP binding site [chemical binding]; other site 1406863005326 Walker B motif; other site 1406863005327 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1406863005328 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1406863005329 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1406863005330 ATP cone domain; Region: ATP-cone; pfam03477 1406863005331 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1406863005332 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1406863005333 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1406863005334 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1406863005335 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1406863005336 CoA-binding site [chemical binding]; other site 1406863005337 ATP-binding [chemical binding]; other site 1406863005338 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1406863005339 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1406863005340 DNA binding site [nucleotide binding] 1406863005341 catalytic residue [active] 1406863005342 H2TH interface [polypeptide binding]; other site 1406863005343 putative catalytic residues [active] 1406863005344 turnover-facilitating residue; other site 1406863005345 intercalation triad [nucleotide binding]; other site 1406863005346 8OG recognition residue [nucleotide binding]; other site 1406863005347 putative reading head residues; other site 1406863005348 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1406863005349 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1406863005350 DNA polymerase I; Provisional; Region: PRK05755 1406863005351 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1406863005352 active site 1406863005353 metal binding site 1 [ion binding]; metal-binding site 1406863005354 putative 5' ssDNA interaction site; other site 1406863005355 metal binding site 3; metal-binding site 1406863005356 metal binding site 2 [ion binding]; metal-binding site 1406863005357 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1406863005358 putative DNA binding site [nucleotide binding]; other site 1406863005359 putative metal binding site [ion binding]; other site 1406863005360 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1406863005361 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1406863005362 active site 1406863005363 DNA binding site [nucleotide binding] 1406863005364 catalytic site [active] 1406863005365 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1406863005366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1406863005367 dimer interface [polypeptide binding]; other site 1406863005368 phosphorylation site [posttranslational modification] 1406863005369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863005370 ATP binding site [chemical binding]; other site 1406863005371 Mg2+ binding site [ion binding]; other site 1406863005372 G-X-G motif; other site 1406863005373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1406863005374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863005375 active site 1406863005376 phosphorylation site [posttranslational modification] 1406863005377 intermolecular recognition site; other site 1406863005378 dimerization interface [polypeptide binding]; other site 1406863005379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1406863005380 DNA binding site [nucleotide binding] 1406863005381 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1406863005382 isocitrate dehydrogenase; Validated; Region: PRK07362 1406863005383 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1406863005384 dimer interface [polypeptide binding]; other site 1406863005385 Citrate synthase; Region: Citrate_synt; pfam00285 1406863005386 active site 1406863005387 citrylCoA binding site [chemical binding]; other site 1406863005388 oxalacetate/citrate binding site [chemical binding]; other site 1406863005389 coenzyme A binding site [chemical binding]; other site 1406863005390 catalytic triad [active] 1406863005391 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1406863005392 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1406863005393 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1406863005394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1406863005395 pyruvate kinase; Provisional; Region: PRK06354 1406863005396 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1406863005397 domain interfaces; other site 1406863005398 active site 1406863005399 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1406863005400 6-phosphofructokinase; Provisional; Region: PRK03202 1406863005401 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1406863005402 active site 1406863005403 ADP/pyrophosphate binding site [chemical binding]; other site 1406863005404 dimerization interface [polypeptide binding]; other site 1406863005405 allosteric effector site; other site 1406863005406 fructose-1,6-bisphosphate binding site; other site 1406863005407 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863005408 MULE transposase domain; Region: MULE; pfam10551 1406863005409 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1406863005410 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1406863005411 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1406863005412 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1406863005413 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1406863005414 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1406863005415 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1406863005416 putative NAD(P) binding site [chemical binding]; other site 1406863005417 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1406863005418 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1406863005419 active site 1406863005420 PHP Thumb interface [polypeptide binding]; other site 1406863005421 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1406863005422 generic binding surface I; other site 1406863005423 generic binding surface II; other site 1406863005424 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1406863005425 DHH family; Region: DHH; pfam01368 1406863005426 DHHA1 domain; Region: DHHA1; pfam02272 1406863005427 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1406863005428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1406863005429 DNA-binding site [nucleotide binding]; DNA binding site 1406863005430 DRTGG domain; Region: DRTGG; pfam07085 1406863005431 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1406863005432 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1406863005433 active site 2 [active] 1406863005434 active site 1 [active] 1406863005435 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1406863005436 Ligand Binding Site [chemical binding]; other site 1406863005437 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1406863005438 metal-dependent hydrolase; Provisional; Region: PRK00685 1406863005439 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1406863005440 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1406863005441 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1406863005442 active site 1406863005443 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1406863005444 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1406863005445 hexamer interface [polypeptide binding]; other site 1406863005446 ligand binding site [chemical binding]; other site 1406863005447 putative active site [active] 1406863005448 NAD(P) binding site [chemical binding]; other site 1406863005449 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1406863005450 Ligand Binding Site [chemical binding]; other site 1406863005451 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1406863005452 propionate/acetate kinase; Provisional; Region: PRK12379 1406863005453 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1406863005454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863005455 S-adenosylmethionine binding site [chemical binding]; other site 1406863005456 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1406863005457 dimer interface [polypeptide binding]; other site 1406863005458 catalytic triad [active] 1406863005459 peroxidatic and resolving cysteines [active] 1406863005460 hypothetical protein; Provisional; Region: PRK10621 1406863005461 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1406863005462 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1406863005463 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1406863005464 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1406863005465 Ligand Binding Site [chemical binding]; other site 1406863005466 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1406863005467 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1406863005468 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1406863005469 catalytic residue [active] 1406863005470 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1406863005471 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1406863005472 GAF domain; Region: GAF_2; pfam13185 1406863005473 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1406863005474 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1406863005475 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1406863005476 RNA binding surface [nucleotide binding]; other site 1406863005477 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1406863005478 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1406863005479 active site 1406863005480 catalytic site [active] 1406863005481 OsmC-like protein; Region: OsmC; cl00767 1406863005482 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1406863005483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1406863005484 catalytic residue [active] 1406863005485 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1406863005486 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1406863005487 ligand binding site [chemical binding]; other site 1406863005488 NAD binding site [chemical binding]; other site 1406863005489 dimerization interface [polypeptide binding]; other site 1406863005490 catalytic site [active] 1406863005491 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1406863005492 putative L-serine binding site [chemical binding]; other site 1406863005493 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1406863005494 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863005495 motif II; other site 1406863005496 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1406863005497 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1406863005498 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1406863005499 active site turn [active] 1406863005500 phosphorylation site [posttranslational modification] 1406863005501 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1406863005502 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1406863005503 putative acyl-acceptor binding pocket; other site 1406863005504 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1406863005505 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1406863005506 protein binding site [polypeptide binding]; other site 1406863005507 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1406863005508 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1406863005509 active site 1406863005510 HIGH motif; other site 1406863005511 dimer interface [polypeptide binding]; other site 1406863005512 KMSKS motif; other site 1406863005513 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1406863005514 RNA binding surface [nucleotide binding]; other site 1406863005515 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1406863005516 Transglycosylase; Region: Transgly; pfam00912 1406863005517 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1406863005518 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1406863005519 NEAr Transporter domain; Region: NEAT; smart00725 1406863005520 NEAr Transporter domain; Region: NEAT; smart00725 1406863005521 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1406863005522 heme-binding site [chemical binding]; other site 1406863005523 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1406863005524 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1406863005525 Potassium binding sites [ion binding]; other site 1406863005526 Cesium cation binding sites [ion binding]; other site 1406863005527 acetyl-CoA synthetase; Provisional; Region: PRK04319 1406863005528 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1406863005529 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1406863005530 active site 1406863005531 acyl-activating enzyme (AAE) consensus motif; other site 1406863005532 putative CoA binding site [chemical binding]; other site 1406863005533 AMP binding site [chemical binding]; other site 1406863005534 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1406863005535 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1406863005536 active site 1406863005537 Zn binding site [ion binding]; other site 1406863005538 catabolite control protein A; Region: ccpA; TIGR01481 1406863005539 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1406863005540 DNA binding site [nucleotide binding] 1406863005541 domain linker motif; other site 1406863005542 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1406863005543 dimerization interface [polypeptide binding]; other site 1406863005544 effector binding site; other site 1406863005545 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1406863005546 Chorismate mutase type II; Region: CM_2; cl00693 1406863005547 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1406863005548 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1406863005549 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1406863005550 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1406863005551 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1406863005552 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1406863005553 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1406863005554 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1406863005555 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1406863005556 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1406863005557 putative tRNA-binding site [nucleotide binding]; other site 1406863005558 hypothetical protein; Provisional; Region: PRK13668 1406863005559 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1406863005560 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1406863005561 catalytic residues [active] 1406863005562 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1406863005563 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1406863005564 oligomer interface [polypeptide binding]; other site 1406863005565 active site 1406863005566 metal binding site [ion binding]; metal-binding site 1406863005567 Predicted small secreted protein [Function unknown]; Region: COG5584 1406863005568 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1406863005569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863005570 S-adenosylmethionine binding site [chemical binding]; other site 1406863005571 Phosphotransferase enzyme family; Region: APH; pfam01636 1406863005572 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1406863005573 active site 1406863005574 substrate binding site [chemical binding]; other site 1406863005575 ATP binding site [chemical binding]; other site 1406863005576 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1406863005577 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1406863005578 homodimer interface [polypeptide binding]; other site 1406863005579 substrate-cofactor binding pocket; other site 1406863005580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863005581 catalytic residue [active] 1406863005582 dipeptidase PepV; Reviewed; Region: PRK07318 1406863005583 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1406863005584 active site 1406863005585 metal binding site [ion binding]; metal-binding site 1406863005586 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1406863005587 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1406863005588 RNA binding surface [nucleotide binding]; other site 1406863005589 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1406863005590 active site 1406863005591 uracil binding [chemical binding]; other site 1406863005592 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1406863005593 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1406863005594 HI0933-like protein; Region: HI0933_like; pfam03486 1406863005595 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863005596 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1406863005597 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005598 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005599 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005600 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005601 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005602 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005603 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005604 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005605 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005606 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005607 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005608 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005609 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005610 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005611 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863005612 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1406863005613 active site residue [active] 1406863005614 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1406863005615 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1406863005616 HIGH motif; other site 1406863005617 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1406863005618 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1406863005619 active site 1406863005620 KMSKS motif; other site 1406863005621 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1406863005622 tRNA binding surface [nucleotide binding]; other site 1406863005623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863005624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863005625 putative substrate translocation pore; other site 1406863005626 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1406863005627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863005628 S-adenosylmethionine binding site [chemical binding]; other site 1406863005629 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863005630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1406863005631 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1406863005632 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1406863005633 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1406863005634 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1406863005635 homopentamer interface [polypeptide binding]; other site 1406863005636 active site 1406863005637 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1406863005638 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1406863005639 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1406863005640 dimerization interface [polypeptide binding]; other site 1406863005641 active site 1406863005642 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1406863005643 Lumazine binding domain; Region: Lum_binding; pfam00677 1406863005644 Lumazine binding domain; Region: Lum_binding; pfam00677 1406863005645 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1406863005646 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1406863005647 catalytic motif [active] 1406863005648 Zn binding site [ion binding]; other site 1406863005649 RibD C-terminal domain; Region: RibD_C; cl17279 1406863005650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1406863005651 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1406863005652 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1406863005653 arsenical pump membrane protein; Provisional; Region: PRK15445 1406863005654 transmembrane helices; other site 1406863005655 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1406863005656 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1406863005657 active site 1406863005658 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1406863005659 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1406863005660 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1406863005661 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1406863005662 DNA binding residues [nucleotide binding] 1406863005663 CAAX protease self-immunity; Region: Abi; pfam02517 1406863005664 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1406863005665 active site 1406863005666 intersubunit interactions; other site 1406863005667 catalytic residue [active] 1406863005668 camphor resistance protein CrcB; Provisional; Region: PRK14201 1406863005669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1406863005670 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1406863005671 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1406863005672 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1406863005673 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1406863005674 active site 1406863005675 catalytic tetrad [active] 1406863005676 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1406863005677 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1406863005678 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1406863005679 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1406863005680 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1406863005681 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1406863005682 active site 1406863005683 substrate-binding site [chemical binding]; other site 1406863005684 metal-binding site [ion binding] 1406863005685 ATP binding site [chemical binding]; other site 1406863005686 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1406863005687 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1406863005688 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1406863005689 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1406863005690 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1406863005691 nudix motif; other site 1406863005692 Haemolytic domain; Region: Haemolytic; pfam01809 1406863005693 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1406863005694 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1406863005695 metal binding site [ion binding]; metal-binding site 1406863005696 substrate binding pocket [chemical binding]; other site 1406863005697 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1406863005698 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1406863005699 acyl-activating enzyme (AAE) consensus motif; other site 1406863005700 putative AMP binding site [chemical binding]; other site 1406863005701 putative active site [active] 1406863005702 putative CoA binding site [chemical binding]; other site 1406863005703 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1406863005704 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1406863005705 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1406863005706 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1406863005707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1406863005708 Transposase; Region: HTH_Tnp_1; cl17663 1406863005709 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1406863005710 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1406863005711 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1406863005712 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1406863005713 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1406863005714 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1406863005715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863005716 S-adenosylmethionine binding site [chemical binding]; other site 1406863005717 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1406863005718 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1406863005719 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1406863005720 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1406863005721 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1406863005722 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1406863005723 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1406863005724 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1406863005725 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1406863005726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863005727 Walker A/P-loop; other site 1406863005728 ATP binding site [chemical binding]; other site 1406863005729 Q-loop/lid; other site 1406863005730 ABC transporter signature motif; other site 1406863005731 Walker B; other site 1406863005732 D-loop; other site 1406863005733 H-loop/switch region; other site 1406863005734 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 1406863005735 active site 1406863005736 catalytic triad [active] 1406863005737 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1406863005738 Flavoprotein; Region: Flavoprotein; pfam02441 1406863005739 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1406863005740 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 1406863005741 active site 1406863005742 zinc binding site [ion binding]; other site 1406863005743 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1406863005744 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1406863005745 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1406863005746 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 1406863005747 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863005748 MULE transposase domain; Region: MULE; pfam10551 1406863005749 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1406863005750 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1406863005751 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1406863005752 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 1406863005753 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1406863005754 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1406863005755 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1406863005756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1406863005757 ferrochelatase; Provisional; Region: PRK12435 1406863005758 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1406863005759 C-terminal domain interface [polypeptide binding]; other site 1406863005760 active site 1406863005761 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1406863005762 active site 1406863005763 N-terminal domain interface [polypeptide binding]; other site 1406863005764 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1406863005765 substrate binding site [chemical binding]; other site 1406863005766 active site 1406863005767 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1406863005768 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1406863005769 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1406863005770 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1406863005771 Walker A/P-loop; other site 1406863005772 ATP binding site [chemical binding]; other site 1406863005773 Q-loop/lid; other site 1406863005774 ABC transporter signature motif; other site 1406863005775 Walker B; other site 1406863005776 D-loop; other site 1406863005777 H-loop/switch region; other site 1406863005778 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1406863005779 HIT family signature motif; other site 1406863005780 catalytic residue [active] 1406863005781 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1406863005782 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1406863005783 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1406863005784 SurA N-terminal domain; Region: SurA_N_3; cl07813 1406863005785 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1406863005786 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1406863005787 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1406863005788 generic binding surface II; other site 1406863005789 generic binding surface I; other site 1406863005790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1406863005791 Zn2+ binding site [ion binding]; other site 1406863005792 Mg2+ binding site [ion binding]; other site 1406863005793 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1406863005794 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1406863005795 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 1406863005796 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1406863005797 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1406863005798 active site 1406863005799 metal binding site [ion binding]; metal-binding site 1406863005800 DNA binding site [nucleotide binding] 1406863005801 hypothetical protein; Provisional; Region: PRK13676 1406863005802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1406863005803 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1406863005804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863005805 non-specific DNA binding site [nucleotide binding]; other site 1406863005806 salt bridge; other site 1406863005807 sequence-specific DNA binding site [nucleotide binding]; other site 1406863005808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1406863005809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863005810 active site 1406863005811 phosphorylation site [posttranslational modification] 1406863005812 intermolecular recognition site; other site 1406863005813 dimerization interface [polypeptide binding]; other site 1406863005814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1406863005815 DNA binding residues [nucleotide binding] 1406863005816 dimerization interface [polypeptide binding]; other site 1406863005817 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1406863005818 GAF domain; Region: GAF_3; pfam13492 1406863005819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1406863005820 Histidine kinase; Region: HisKA_3; pfam07730 1406863005821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863005822 ATP binding site [chemical binding]; other site 1406863005823 Mg2+ binding site [ion binding]; other site 1406863005824 G-X-G motif; other site 1406863005825 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1406863005826 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1406863005827 active site 1406863005828 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1406863005829 Class II fumarases; Region: Fumarase_classII; cd01362 1406863005830 active site 1406863005831 tetramer interface [polypeptide binding]; other site 1406863005832 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1406863005833 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1406863005834 active site 1406863005835 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1406863005836 epoxyqueuosine reductase; Region: TIGR00276 1406863005837 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1406863005838 HEAT repeats; Region: HEAT_2; pfam13646 1406863005839 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1406863005840 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1406863005841 Walker A/P-loop; other site 1406863005842 ATP binding site [chemical binding]; other site 1406863005843 Q-loop/lid; other site 1406863005844 ABC transporter signature motif; other site 1406863005845 Walker B; other site 1406863005846 D-loop; other site 1406863005847 H-loop/switch region; other site 1406863005848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1406863005849 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1406863005850 substrate binding pocket [chemical binding]; other site 1406863005851 membrane-bound complex binding site; other site 1406863005852 hinge residues; other site 1406863005853 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1406863005854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863005855 dimer interface [polypeptide binding]; other site 1406863005856 conserved gate region; other site 1406863005857 putative PBP binding loops; other site 1406863005858 ABC-ATPase subunit interface; other site 1406863005859 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1406863005860 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1406863005861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1406863005862 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1406863005863 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1406863005864 metal binding site 2 [ion binding]; metal-binding site 1406863005865 putative DNA binding helix; other site 1406863005866 metal binding site 1 [ion binding]; metal-binding site 1406863005867 dimer interface [polypeptide binding]; other site 1406863005868 structural Zn2+ binding site [ion binding]; other site 1406863005869 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1406863005870 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1406863005871 putative ligand binding site [chemical binding]; other site 1406863005872 NAD binding site [chemical binding]; other site 1406863005873 catalytic site [active] 1406863005874 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1406863005875 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1406863005876 catalytic triad [active] 1406863005877 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1406863005878 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1406863005879 inhibitor-cofactor binding pocket; inhibition site 1406863005880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863005881 catalytic residue [active] 1406863005882 Predicted membrane protein [Function unknown]; Region: COG4129 1406863005883 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1406863005884 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1406863005885 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1406863005886 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1406863005887 Walker A/P-loop; other site 1406863005888 ATP binding site [chemical binding]; other site 1406863005889 Q-loop/lid; other site 1406863005890 ABC transporter signature motif; other site 1406863005891 Walker B; other site 1406863005892 D-loop; other site 1406863005893 H-loop/switch region; other site 1406863005894 hypothetical protein; Provisional; Region: PRK13662 1406863005895 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1406863005896 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1406863005897 minor groove reading motif; other site 1406863005898 helix-hairpin-helix signature motif; other site 1406863005899 substrate binding pocket [chemical binding]; other site 1406863005900 active site 1406863005901 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1406863005902 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1406863005903 DNA binding and oxoG recognition site [nucleotide binding] 1406863005904 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1406863005905 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1406863005906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863005907 Walker A/P-loop; other site 1406863005908 ATP binding site [chemical binding]; other site 1406863005909 Q-loop/lid; other site 1406863005910 ABC transporter signature motif; other site 1406863005911 Walker B; other site 1406863005912 H-loop/switch region; other site 1406863005913 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1406863005914 recombination regulator RecX; Provisional; Region: recX; PRK14135 1406863005915 glycosyltransferase; Provisional; Region: PRK13481 1406863005916 Transglycosylase; Region: Transgly; pfam00912 1406863005917 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1406863005918 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1406863005919 proposed catalytic triad [active] 1406863005920 conserved cys residue [active] 1406863005921 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1406863005922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863005923 FeS/SAM binding site; other site 1406863005924 YfkB-like domain; Region: YfkB; pfam08756 1406863005925 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1406863005926 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1406863005927 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1406863005928 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1406863005929 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1406863005930 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1406863005931 active site 1406863005932 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1406863005933 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1406863005934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863005935 active site 1406863005936 phosphorylation site [posttranslational modification] 1406863005937 intermolecular recognition site; other site 1406863005938 dimerization interface [polypeptide binding]; other site 1406863005939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1406863005940 DNA binding residues [nucleotide binding] 1406863005941 dimerization interface [polypeptide binding]; other site 1406863005942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1406863005943 Histidine kinase; Region: HisKA_3; pfam07730 1406863005944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863005945 ATP binding site [chemical binding]; other site 1406863005946 Mg2+ binding site [ion binding]; other site 1406863005947 G-X-G motif; other site 1406863005948 Predicted membrane protein [Function unknown]; Region: COG4758 1406863005949 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1406863005950 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1406863005951 active site 1406863005952 Predicted membrane protein [Function unknown]; Region: COG4129 1406863005953 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1406863005954 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1406863005955 catalytic triad [active] 1406863005956 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1406863005957 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1406863005958 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1406863005959 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1406863005960 Ferritin-like domain; Region: Ferritin; pfam00210 1406863005961 ferroxidase diiron center [ion binding]; other site 1406863005962 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1406863005963 active site 1406863005964 catalytic site [active] 1406863005965 substrate binding site [chemical binding]; other site 1406863005966 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1406863005967 active site 1406863005968 DNA polymerase IV; Validated; Region: PRK02406 1406863005969 DNA binding site [nucleotide binding] 1406863005970 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1406863005971 TRAM domain; Region: TRAM; cl01282 1406863005972 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1406863005973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863005974 S-adenosylmethionine binding site [chemical binding]; other site 1406863005975 putative lipid kinase; Reviewed; Region: PRK13337 1406863005976 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1406863005977 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1406863005978 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1406863005979 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1406863005980 GatB domain; Region: GatB_Yqey; pfam02637 1406863005981 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1406863005982 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1406863005983 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1406863005984 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1406863005985 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1406863005986 Na binding site [ion binding]; other site 1406863005987 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1406863005988 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1406863005989 putative dimer interface [polypeptide binding]; other site 1406863005990 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1406863005991 putative dimer interface [polypeptide binding]; other site 1406863005992 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1406863005993 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1406863005994 nucleotide binding pocket [chemical binding]; other site 1406863005995 K-X-D-G motif; other site 1406863005996 catalytic site [active] 1406863005997 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1406863005998 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1406863005999 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1406863006000 Dimer interface [polypeptide binding]; other site 1406863006001 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1406863006002 Part of AAA domain; Region: AAA_19; pfam13245 1406863006003 Family description; Region: UvrD_C_2; pfam13538 1406863006004 PcrB family; Region: PcrB; pfam01884 1406863006005 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1406863006006 substrate binding site [chemical binding]; other site 1406863006007 putative active site [active] 1406863006008 dimer interface [polypeptide binding]; other site 1406863006009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1406863006010 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1406863006011 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1406863006012 tetramer interface [polypeptide binding]; other site 1406863006013 active site 1406863006014 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1406863006015 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1406863006016 Staphostatin A; Region: Staphostatin_A; pfam09022 1406863006017 NETI protein; Region: NETI; pfam14044 1406863006018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1406863006019 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1406863006020 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1406863006021 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1406863006022 homodimer interface [polypeptide binding]; other site 1406863006023 NAD binding pocket [chemical binding]; other site 1406863006024 ATP binding pocket [chemical binding]; other site 1406863006025 Mg binding site [ion binding]; other site 1406863006026 active-site loop [active] 1406863006027 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1406863006028 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1406863006029 active site 1406863006030 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1406863006031 active site 1406863006032 dimer interface [polypeptide binding]; other site 1406863006033 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1406863006034 Prephenate dehydratase; Region: PDT; pfam00800 1406863006035 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1406863006036 putative L-Phe binding site [chemical binding]; other site 1406863006037 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1406863006038 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1406863006039 transmembrane helices; other site 1406863006040 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1406863006041 Isochorismatase family; Region: Isochorismatase; pfam00857 1406863006042 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1406863006043 catalytic triad [active] 1406863006044 conserved cis-peptide bond; other site 1406863006045 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1406863006046 DHH family; Region: DHH; pfam01368 1406863006047 DHHA2 domain; Region: DHHA2; pfam02833 1406863006048 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1406863006049 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1406863006050 NAD(P) binding site [chemical binding]; other site 1406863006051 catalytic residues [active] 1406863006052 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1406863006053 YolD-like protein; Region: YolD; pfam08863 1406863006054 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1406863006055 active site 1406863006056 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1406863006057 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1406863006058 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1406863006059 Bacterial PH domain; Region: DUF304; cl01348 1406863006060 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 1406863006061 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1406863006062 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1406863006063 Walker A/P-loop; other site 1406863006064 ATP binding site [chemical binding]; other site 1406863006065 Q-loop/lid; other site 1406863006066 ABC transporter signature motif; other site 1406863006067 Walker B; other site 1406863006068 D-loop; other site 1406863006069 H-loop/switch region; other site 1406863006070 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1406863006071 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1406863006072 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1406863006073 Walker A/P-loop; other site 1406863006074 ATP binding site [chemical binding]; other site 1406863006075 Q-loop/lid; other site 1406863006076 ABC transporter signature motif; other site 1406863006077 Walker B; other site 1406863006078 D-loop; other site 1406863006079 H-loop/switch region; other site 1406863006080 Predicted transcriptional regulators [Transcription]; Region: COG1725 1406863006081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1406863006082 DNA-binding site [nucleotide binding]; DNA binding site 1406863006083 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1406863006084 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1406863006085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863006086 homodimer interface [polypeptide binding]; other site 1406863006087 catalytic residue [active] 1406863006088 prophage phiSa3(Z172) 1406863006089 MAP domain; Region: MAP; pfam03642 1406863006090 MAP domain; Region: MAP; pfam03642 1406863006091 MAP domain; Region: MAP; pfam03642 1406863006092 MAP domain; Region: MAP; pfam03642 1406863006093 MAP domain; Region: MAP; pfam03642 1406863006094 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1406863006095 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1406863006096 Bacterial SH3 domain; Region: SH3_5; pfam08460 1406863006097 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 1406863006098 CHAP domain; Region: CHAP; pfam05257 1406863006099 Small integral membrane protein [Function unknown]; Region: COG5546 1406863006100 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1406863006101 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1406863006102 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1406863006103 Ligand-gated ion channel; Region: Lig_chan; pfam00060 1406863006104 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 1406863006105 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1406863006106 TolA protein; Region: tolA_full; TIGR02794 1406863006107 Phage tail protein; Region: Sipho_tail; cl17486 1406863006108 Phage tail protein; Region: Sipho_tail; cl17486 1406863006109 Phage-related minor tail protein [Function unknown]; Region: COG5280 1406863006110 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1406863006111 Phage-related protein [Function unknown]; Region: COG5412 1406863006112 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 1406863006113 Peptidase family M23; Region: Peptidase_M23; pfam01551 1406863006114 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1406863006115 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1406863006116 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1406863006117 catalytic residue [active] 1406863006118 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1406863006119 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1406863006120 Translocation protein Sec62; Region: Sec62; cl02170 1406863006121 Phage capsid family; Region: Phage_capsid; pfam05065 1406863006122 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1406863006123 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1406863006124 oligomer interface [polypeptide binding]; other site 1406863006125 active site residues [active] 1406863006126 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1406863006127 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1406863006128 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1406863006129 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1406863006130 HNH endonuclease; Region: HNH; pfam01844 1406863006131 active site 1406863006132 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1406863006133 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1406863006134 Transcriptional activator RinB; Region: RinB; pfam06116 1406863006135 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1406863006136 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1406863006137 dUTPase; Region: dUTPase_2; pfam08761 1406863006138 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1406863006139 active site 1406863006140 homodimer interface [polypeptide binding]; other site 1406863006141 metal binding site [ion binding]; metal-binding site 1406863006142 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1406863006143 YopX protein; Region: YopX; pfam09643 1406863006144 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1406863006145 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 1406863006146 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1406863006147 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1406863006148 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1406863006149 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1406863006150 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1406863006151 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1406863006152 dimer interface [polypeptide binding]; other site 1406863006153 ssDNA binding site [nucleotide binding]; other site 1406863006154 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1406863006155 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1406863006156 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 1406863006157 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1406863006158 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1406863006159 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 1406863006160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 1406863006161 AntA/AntB antirepressor; Region: AntA; cl01430 1406863006162 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1406863006163 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1406863006164 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1406863006165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1406863006166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863006167 non-specific DNA binding site [nucleotide binding]; other site 1406863006168 salt bridge; other site 1406863006169 sequence-specific DNA binding site [nucleotide binding]; other site 1406863006170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863006171 non-specific DNA binding site [nucleotide binding]; other site 1406863006172 salt bridge; other site 1406863006173 sequence-specific DNA binding site [nucleotide binding]; other site 1406863006174 Predicted transcriptional regulator [Transcription]; Region: COG2932 1406863006175 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1406863006176 Catalytic site [active] 1406863006177 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1406863006178 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1406863006179 active site 1406863006180 catalytic site [active] 1406863006181 substrate binding site [chemical binding]; other site 1406863006182 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1406863006183 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1406863006184 Int/Topo IB signature motif; other site 1406863006185 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1406863006186 putative catalytic site [active] 1406863006187 phosphate binding site [ion binding]; other site 1406863006188 metal binding site A [ion binding]; metal-binding site 1406863006189 metal binding site C [ion binding]; metal-binding site 1406863006190 metal binding site B [ion binding]; metal-binding site 1406863006191 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1406863006192 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1406863006193 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1406863006194 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1406863006195 metal binding site [ion binding]; metal-binding site 1406863006196 dimer interface [polypeptide binding]; other site 1406863006197 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1406863006198 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1406863006199 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1406863006200 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1406863006201 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1406863006202 putative ligand binding residues [chemical binding]; other site 1406863006203 Cation transport protein; Region: TrkH; cl17365 1406863006204 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1406863006205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863006206 Coenzyme A binding pocket [chemical binding]; other site 1406863006207 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1406863006208 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1406863006209 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1406863006210 ring oligomerisation interface [polypeptide binding]; other site 1406863006211 ATP/Mg binding site [chemical binding]; other site 1406863006212 stacking interactions; other site 1406863006213 hinge regions; other site 1406863006214 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1406863006215 oligomerisation interface [polypeptide binding]; other site 1406863006216 mobile loop; other site 1406863006217 roof hairpin; other site 1406863006218 CAAX protease self-immunity; Region: Abi; pfam02517 1406863006219 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1406863006220 dimer interface [polypeptide binding]; other site 1406863006221 FMN binding site [chemical binding]; other site 1406863006222 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1406863006223 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1406863006224 putative active site [active] 1406863006225 catalytic triad [active] 1406863006226 putative dimer interface [polypeptide binding]; other site 1406863006227 delta-hemolysin; Provisional; Region: PRK14752 1406863006228 Accessory gene regulator B; Region: AgrB; smart00793 1406863006229 Staphylococcal AgrD protein; Region: AgrD; smart00794 1406863006230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863006231 Mg2+ binding site [ion binding]; other site 1406863006232 G-X-G motif; other site 1406863006233 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1406863006234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863006235 active site 1406863006236 phosphorylation site [posttranslational modification] 1406863006237 intermolecular recognition site; other site 1406863006238 dimerization interface [polypeptide binding]; other site 1406863006239 LytTr DNA-binding domain; Region: LytTR; pfam04397 1406863006240 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1406863006241 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1406863006242 putative substrate binding site [chemical binding]; other site 1406863006243 putative ATP binding site [chemical binding]; other site 1406863006244 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1406863006245 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1406863006246 substrate binding [chemical binding]; other site 1406863006247 active site 1406863006248 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1406863006249 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1406863006250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1406863006251 DNA binding site [nucleotide binding] 1406863006252 domain linker motif; other site 1406863006253 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1406863006254 dimerization interface [polypeptide binding]; other site 1406863006255 ligand binding site [chemical binding]; other site 1406863006256 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1406863006257 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1406863006258 CPxP motif; other site 1406863006259 Sulphur transport; Region: Sulf_transp; pfam04143 1406863006260 prophage phiSPbeta-like(Z172) 1406863006261 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1406863006262 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1406863006263 catalytic residues [active] 1406863006264 catalytic nucleophile [active] 1406863006265 Recombinase; Region: Recombinase; pfam07508 1406863006266 Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921 1406863006267 DNA binding site [nucleotide binding] 1406863006268 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1406863006269 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 1406863006270 putative nucleotide binding site [chemical binding]; other site 1406863006271 putative metal binding site [ion binding]; other site 1406863006272 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1406863006273 catalytic residues [active] 1406863006274 hypothetical protein; Provisional; Region: PRK01184 1406863006275 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1406863006276 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1406863006277 dimer interface [polypeptide binding]; other site 1406863006278 putative radical transfer pathway; other site 1406863006279 diiron center [ion binding]; other site 1406863006280 tyrosyl radical; other site 1406863006281 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1406863006282 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1406863006283 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1406863006284 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1406863006285 protein-splicing catalytic site; other site 1406863006286 thioester formation/cholesterol transfer; other site 1406863006287 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1406863006288 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1406863006289 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 1406863006290 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 1406863006291 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1406863006292 hypothetical protein; Region: PHA02246 1406863006293 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1406863006294 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1406863006295 cofactor binding site; other site 1406863006296 DNA binding site [nucleotide binding] 1406863006297 substrate interaction site [chemical binding]; other site 1406863006298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863006299 S-adenosylmethionine binding site [chemical binding]; other site 1406863006300 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1406863006301 DNA ligase; Provisional; Region: 30; PHA02587 1406863006302 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 1406863006303 DNA binding site [nucleotide binding] 1406863006304 active site 1406863006305 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 1406863006306 DNA binding site [nucleotide binding] 1406863006307 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1406863006308 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1406863006309 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1406863006310 active site 1406863006311 RibD C-terminal domain; Region: RibD_C; cl17279 1406863006312 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863006313 MULE transposase domain; Region: MULE; pfam10551 1406863006314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1406863006315 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1406863006316 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1406863006317 Phosphotransferase enzyme family; Region: APH; pfam01636 1406863006318 active site 1406863006319 ATP binding site [chemical binding]; other site 1406863006320 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1406863006321 substrate binding site [chemical binding]; other site 1406863006322 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1406863006323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863006324 Coenzyme A binding pocket [chemical binding]; other site 1406863006325 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863006326 MULE transposase domain; Region: MULE; pfam10551 1406863006327 RibD C-terminal domain; Region: RibD_C; cl17279 1406863006328 WYL domain; Region: WYL; pfam13280 1406863006329 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1406863006330 active site 1406863006331 ATP binding site [chemical binding]; other site 1406863006332 Phosphotransferase enzyme family; Region: APH; pfam01636 1406863006333 antibiotic binding site [chemical binding]; other site 1406863006334 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1406863006335 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1406863006336 active site 1406863006337 metal binding site [ion binding]; metal-binding site 1406863006338 Fic/DOC family; Region: Fic; cl00960 1406863006339 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1406863006340 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1406863006341 putative active site [active] 1406863006342 putative metal binding site [ion binding]; other site 1406863006343 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1406863006344 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1406863006345 active site 1406863006346 metal binding site [ion binding]; metal-binding site 1406863006347 VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; Region: VHS_ENTH_ANTH; cl02544 1406863006348 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 1406863006349 Transcriptional activator RinB; Region: RinB; pfam06116 1406863006350 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1406863006351 Catalytic site; other site 1406863006352 YopX protein; Region: YopX; cl09859 1406863006353 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1406863006354 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1406863006355 DHH family; Region: DHH; pfam01368 1406863006356 hypothetical protein; Provisional; Region: PRK08624 1406863006357 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1406863006358 active site 1406863006359 metal binding site [ion binding]; metal-binding site 1406863006360 interdomain interaction site; other site 1406863006361 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 1406863006362 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1406863006363 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1406863006364 ATP binding site [chemical binding]; other site 1406863006365 Walker B motif; other site 1406863006366 AAA domain; Region: AAA_24; pfam13479 1406863006367 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 1406863006368 DNA-sulfur modification-associated; Region: DndB; cl17621 1406863006369 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1406863006370 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1406863006371 active site 1406863006372 catalytic residues [active] 1406863006373 DNA binding site [nucleotide binding] 1406863006374 Int/Topo IB signature motif; other site 1406863006375 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863006376 MULE transposase domain; Region: MULE; pfam10551 1406863006377 CHAP domain; Region: CHAP; pfam05257 1406863006378 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1406863006379 active site 1406863006380 metal binding site [ion binding]; metal-binding site 1406863006381 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1406863006382 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1406863006383 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1406863006384 CoA binding domain; Region: CoA_binding; pfam02629 1406863006385 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1406863006386 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1406863006387 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1406863006388 ABC transporter; Region: ABC_tran_2; pfam12848 1406863006389 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1406863006390 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1406863006391 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 1406863006392 Walker A/P-loop; other site 1406863006393 ATP binding site [chemical binding]; other site 1406863006394 Q-loop/lid; other site 1406863006395 ABC transporter signature motif; other site 1406863006396 Walker B; other site 1406863006397 D-loop; other site 1406863006398 H-loop/switch region; other site 1406863006399 UGMP family protein; Validated; Region: PRK09604 1406863006400 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1406863006401 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1406863006402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863006403 Coenzyme A binding pocket [chemical binding]; other site 1406863006404 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1406863006405 Glycoprotease family; Region: Peptidase_M22; pfam00814 1406863006406 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1406863006407 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1406863006408 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1406863006409 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1406863006410 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1406863006411 PYR/PP interface [polypeptide binding]; other site 1406863006412 dimer interface [polypeptide binding]; other site 1406863006413 TPP binding site [chemical binding]; other site 1406863006414 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1406863006415 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1406863006416 TPP-binding site [chemical binding]; other site 1406863006417 dimer interface [polypeptide binding]; other site 1406863006418 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 1406863006419 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1406863006420 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1406863006421 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1406863006422 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1406863006423 2-isopropylmalate synthase; Validated; Region: PRK00915 1406863006424 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1406863006425 active site 1406863006426 catalytic residues [active] 1406863006427 metal binding site [ion binding]; metal-binding site 1406863006428 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1406863006429 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1406863006430 tartrate dehydrogenase; Region: TTC; TIGR02089 1406863006431 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1406863006432 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1406863006433 substrate binding site [chemical binding]; other site 1406863006434 ligand binding site [chemical binding]; other site 1406863006435 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1406863006436 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1406863006437 substrate binding site [chemical binding]; other site 1406863006438 threonine dehydratase; Validated; Region: PRK08639 1406863006439 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1406863006440 tetramer interface [polypeptide binding]; other site 1406863006441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863006442 catalytic residue [active] 1406863006443 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1406863006444 putative Ile/Val binding site [chemical binding]; other site 1406863006445 hypothetical protein; Provisional; Region: PRK04351 1406863006446 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1406863006447 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1406863006448 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1406863006449 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1406863006450 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1406863006451 RNA binding site [nucleotide binding]; other site 1406863006452 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1406863006453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1406863006454 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1406863006455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1406863006456 DNA binding residues [nucleotide binding] 1406863006457 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1406863006458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863006459 ATP binding site [chemical binding]; other site 1406863006460 Mg2+ binding site [ion binding]; other site 1406863006461 G-X-G motif; other site 1406863006462 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1406863006463 anti sigma factor interaction site; other site 1406863006464 regulatory phosphorylation site [posttranslational modification]; other site 1406863006465 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1406863006466 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1406863006467 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1406863006468 PemK-like protein; Region: PemK; pfam02452 1406863006469 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1406863006470 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1406863006471 active site 1406863006472 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1406863006473 dimer interface [polypeptide binding]; other site 1406863006474 substrate binding site [chemical binding]; other site 1406863006475 catalytic residues [active] 1406863006476 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1406863006477 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1406863006478 Predicted membrane protein [Function unknown]; Region: COG3428 1406863006479 Bacterial PH domain; Region: DUF304; pfam03703 1406863006480 Bacterial PH domain; Region: DUF304; pfam03703 1406863006481 Bacterial PH domain; Region: DUF304; cl01348 1406863006482 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 1406863006483 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1406863006484 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1406863006485 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1406863006486 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1406863006487 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1406863006488 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1406863006489 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1406863006490 Ligand Binding Site [chemical binding]; other site 1406863006491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1406863006492 dimer interface [polypeptide binding]; other site 1406863006493 phosphorylation site [posttranslational modification] 1406863006494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863006495 ATP binding site [chemical binding]; other site 1406863006496 Mg2+ binding site [ion binding]; other site 1406863006497 G-X-G motif; other site 1406863006498 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1406863006499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863006500 active site 1406863006501 phosphorylation site [posttranslational modification] 1406863006502 intermolecular recognition site; other site 1406863006503 dimerization interface [polypeptide binding]; other site 1406863006504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1406863006505 DNA binding site [nucleotide binding] 1406863006506 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1406863006507 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1406863006508 ATP binding site [chemical binding]; other site 1406863006509 Mg++ binding site [ion binding]; other site 1406863006510 motif III; other site 1406863006511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1406863006512 nucleotide binding region [chemical binding]; other site 1406863006513 ATP-binding site [chemical binding]; other site 1406863006514 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1406863006515 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1406863006516 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1406863006517 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1406863006518 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1406863006519 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1406863006520 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1406863006521 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1406863006522 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1406863006523 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1406863006524 putative homodimer interface [polypeptide binding]; other site 1406863006525 putative homotetramer interface [polypeptide binding]; other site 1406863006526 allosteric switch controlling residues; other site 1406863006527 putative metal binding site [ion binding]; other site 1406863006528 putative homodimer-homodimer interface [polypeptide binding]; other site 1406863006529 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1406863006530 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1406863006531 putative active site [active] 1406863006532 catalytic site [active] 1406863006533 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1406863006534 putative active site [active] 1406863006535 catalytic site [active] 1406863006536 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1406863006537 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1406863006538 Zn2+ binding site [ion binding]; other site 1406863006539 Mg2+ binding site [ion binding]; other site 1406863006540 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1406863006541 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1406863006542 thiamine phosphate binding site [chemical binding]; other site 1406863006543 active site 1406863006544 pyrophosphate binding site [ion binding]; other site 1406863006545 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1406863006546 substrate binding site [chemical binding]; other site 1406863006547 multimerization interface [polypeptide binding]; other site 1406863006548 ATP binding site [chemical binding]; other site 1406863006549 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1406863006550 dimer interface [polypeptide binding]; other site 1406863006551 substrate binding site [chemical binding]; other site 1406863006552 ATP binding site [chemical binding]; other site 1406863006553 thiaminase II; Region: salvage_TenA; TIGR04306 1406863006554 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1406863006555 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1406863006556 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1406863006557 dimer interface [polypeptide binding]; other site 1406863006558 ssDNA binding site [nucleotide binding]; other site 1406863006559 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1406863006560 YwpF-like protein; Region: YwpF; pfam14183 1406863006561 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1406863006562 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1406863006563 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1406863006564 hinge; other site 1406863006565 active site 1406863006566 Predicted membrane protein [Function unknown]; Region: COG4836 1406863006567 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 1406863006568 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1406863006569 gamma subunit interface [polypeptide binding]; other site 1406863006570 epsilon subunit interface [polypeptide binding]; other site 1406863006571 LBP interface [polypeptide binding]; other site 1406863006572 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1406863006573 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1406863006574 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1406863006575 alpha subunit interaction interface [polypeptide binding]; other site 1406863006576 Walker A motif; other site 1406863006577 ATP binding site [chemical binding]; other site 1406863006578 Walker B motif; other site 1406863006579 inhibitor binding site; inhibition site 1406863006580 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1406863006581 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1406863006582 core domain interface [polypeptide binding]; other site 1406863006583 delta subunit interface [polypeptide binding]; other site 1406863006584 epsilon subunit interface [polypeptide binding]; other site 1406863006585 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1406863006586 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1406863006587 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1406863006588 beta subunit interaction interface [polypeptide binding]; other site 1406863006589 Walker A motif; other site 1406863006590 ATP binding site [chemical binding]; other site 1406863006591 Walker B motif; other site 1406863006592 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1406863006593 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1406863006594 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1406863006595 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1406863006596 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1406863006597 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1406863006598 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1406863006599 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1406863006600 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1406863006601 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1406863006602 active site 1406863006603 homodimer interface [polypeptide binding]; other site 1406863006604 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1406863006605 active site 1406863006606 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1406863006607 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1406863006608 dimer interface [polypeptide binding]; other site 1406863006609 active site 1406863006610 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1406863006611 folate binding site [chemical binding]; other site 1406863006612 hypothetical protein; Provisional; Region: PRK13690 1406863006613 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1406863006614 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1406863006615 active site 1406863006616 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1406863006617 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1406863006618 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1406863006619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863006620 S-adenosylmethionine binding site [chemical binding]; other site 1406863006621 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1406863006622 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1406863006623 RF-1 domain; Region: RF-1; pfam00472 1406863006624 thymidine kinase; Provisional; Region: PRK04296 1406863006625 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1406863006626 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1406863006627 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1406863006628 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1406863006629 RNA binding site [nucleotide binding]; other site 1406863006630 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1406863006631 multimer interface [polypeptide binding]; other site 1406863006632 Walker A motif; other site 1406863006633 ATP binding site [chemical binding]; other site 1406863006634 Walker B motif; other site 1406863006635 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1406863006636 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1406863006637 NAD binding site [chemical binding]; other site 1406863006638 catalytic residues [active] 1406863006639 Predicted transcriptional regulators [Transcription]; Region: COG1733 1406863006640 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1406863006641 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1406863006642 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1406863006643 hinge; other site 1406863006644 active site 1406863006645 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1406863006646 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1406863006647 intersubunit interface [polypeptide binding]; other site 1406863006648 active site 1406863006649 zinc binding site [ion binding]; other site 1406863006650 Na+ binding site [ion binding]; other site 1406863006651 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1406863006652 CTP synthetase; Validated; Region: pyrG; PRK05380 1406863006653 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1406863006654 Catalytic site [active] 1406863006655 active site 1406863006656 UTP binding site [chemical binding]; other site 1406863006657 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1406863006658 active site 1406863006659 putative oxyanion hole; other site 1406863006660 catalytic triad [active] 1406863006661 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1406863006662 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1406863006663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863006664 Coenzyme A binding pocket [chemical binding]; other site 1406863006665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1406863006666 Coenzyme A binding pocket [chemical binding]; other site 1406863006667 pantothenate kinase; Provisional; Region: PRK13317 1406863006668 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1406863006669 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1406863006670 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1406863006671 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1406863006672 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1406863006673 metal binding site [ion binding]; metal-binding site 1406863006674 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1406863006675 Predicted membrane protein [Function unknown]; Region: COG4270 1406863006676 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1406863006677 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1406863006678 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1406863006679 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1406863006680 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1406863006681 intersubunit interface [polypeptide binding]; other site 1406863006682 active site 1406863006683 catalytic residue [active] 1406863006684 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1406863006685 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1406863006686 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1406863006687 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1406863006688 dimerization interface [polypeptide binding]; other site 1406863006689 DPS ferroxidase diiron center [ion binding]; other site 1406863006690 ion pore; other site 1406863006691 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1406863006692 EVE domain; Region: EVE; cl00728 1406863006693 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1406863006694 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1406863006695 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1406863006696 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1406863006697 NAD(P) binding site [chemical binding]; other site 1406863006698 putative active site [active] 1406863006699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1406863006700 dimerization interface [polypeptide binding]; other site 1406863006701 putative DNA binding site [nucleotide binding]; other site 1406863006702 putative Zn2+ binding site [ion binding]; other site 1406863006703 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1406863006704 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1406863006705 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1406863006706 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1406863006707 catalytic residues [active] 1406863006708 SAP domain; Region: SAP; pfam02037 1406863006709 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1406863006710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863006711 active site 1406863006712 motif I; other site 1406863006713 motif II; other site 1406863006714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863006715 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1406863006716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863006717 Walker A/P-loop; other site 1406863006718 ATP binding site [chemical binding]; other site 1406863006719 Q-loop/lid; other site 1406863006720 ABC transporter signature motif; other site 1406863006721 Walker B; other site 1406863006722 D-loop; other site 1406863006723 H-loop/switch region; other site 1406863006724 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1406863006725 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1406863006726 glutaminase active site [active] 1406863006727 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1406863006728 dimer interface [polypeptide binding]; other site 1406863006729 active site 1406863006730 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1406863006731 dimer interface [polypeptide binding]; other site 1406863006732 active site 1406863006733 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1406863006734 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1406863006735 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1406863006736 active site 1406863006737 P-loop; other site 1406863006738 phosphorylation site [posttranslational modification] 1406863006739 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1406863006740 HTH domain; Region: HTH_11; pfam08279 1406863006741 Mga helix-turn-helix domain; Region: Mga; pfam05043 1406863006742 PRD domain; Region: PRD; pfam00874 1406863006743 PRD domain; Region: PRD; pfam00874 1406863006744 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1406863006745 active site 1406863006746 P-loop; other site 1406863006747 phosphorylation site [posttranslational modification] 1406863006748 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1406863006749 active site 1406863006750 phosphorylation site [posttranslational modification] 1406863006751 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1406863006752 active site 1406863006753 phosphorylation site [posttranslational modification] 1406863006754 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1406863006755 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1406863006756 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1406863006757 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863006758 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1406863006759 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863006760 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863006761 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863006762 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863006763 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863006764 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1406863006765 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1406863006766 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1406863006767 active site 1406863006768 substrate binding site [chemical binding]; other site 1406863006769 metal binding site [ion binding]; metal-binding site 1406863006770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1406863006771 YbbR-like protein; Region: YbbR; pfam07949 1406863006772 TIGR00159 family protein; Region: TIGR00159 1406863006773 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1406863006774 Arginase family; Region: Arginase; cd09989 1406863006775 active site 1406863006776 Mn binding site [ion binding]; other site 1406863006777 oligomer interface [polypeptide binding]; other site 1406863006778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1406863006779 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1406863006780 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1406863006781 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1406863006782 Walker A motif; other site 1406863006783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863006784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863006785 putative substrate translocation pore; other site 1406863006786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863006787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863006788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863006789 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1406863006790 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1406863006791 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1406863006792 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1406863006793 substrate binding site; other site 1406863006794 dimerization interface; other site 1406863006795 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1406863006796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1406863006797 Nucleoside recognition; Region: Gate; pfam07670 1406863006798 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1406863006799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863006800 ABC-ATPase subunit interface; other site 1406863006801 dimer interface [polypeptide binding]; other site 1406863006802 putative PBP binding regions; other site 1406863006803 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1406863006804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1406863006805 ABC-ATPase subunit interface; other site 1406863006806 dimer interface [polypeptide binding]; other site 1406863006807 putative PBP binding regions; other site 1406863006808 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1406863006809 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1406863006810 siderophore binding site; other site 1406863006811 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1406863006812 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1406863006813 dimer interface [polypeptide binding]; other site 1406863006814 active site 1406863006815 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1406863006816 substrate binding site [chemical binding]; other site 1406863006817 catalytic residue [active] 1406863006818 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1406863006819 IucA / IucC family; Region: IucA_IucC; pfam04183 1406863006820 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1406863006821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863006822 putative substrate translocation pore; other site 1406863006823 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1406863006824 IucA / IucC family; Region: IucA_IucC; pfam04183 1406863006825 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1406863006826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1406863006827 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1406863006828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1406863006829 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1406863006830 Asp23 family; Region: Asp23; pfam03780 1406863006831 Small integral membrane protein [Function unknown]; Region: COG5547 1406863006832 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1406863006833 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1406863006834 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1406863006835 putative NAD(P) binding site [chemical binding]; other site 1406863006836 dimer interface [polypeptide binding]; other site 1406863006837 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1406863006838 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1406863006839 NAD(P) binding site [chemical binding]; other site 1406863006840 substrate binding site [chemical binding]; other site 1406863006841 dimer interface [polypeptide binding]; other site 1406863006842 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1406863006843 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1406863006844 beta-galactosidase; Region: BGL; TIGR03356 1406863006845 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1406863006846 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1406863006847 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1406863006848 active site 1406863006849 P-loop; other site 1406863006850 phosphorylation site [posttranslational modification] 1406863006851 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1406863006852 methionine cluster; other site 1406863006853 active site 1406863006854 phosphorylation site [posttranslational modification] 1406863006855 metal binding site [ion binding]; metal-binding site 1406863006856 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1406863006857 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1406863006858 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1406863006859 putative substrate binding site [chemical binding]; other site 1406863006860 putative ATP binding site [chemical binding]; other site 1406863006861 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1406863006862 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1406863006863 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1406863006864 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1406863006865 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1406863006866 NAD-dependent deacetylase; Provisional; Region: PRK00481 1406863006867 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1406863006868 NAD+ binding site [chemical binding]; other site 1406863006869 substrate binding site [chemical binding]; other site 1406863006870 putative Zn binding site [ion binding]; other site 1406863006871 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1406863006872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1406863006873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1406863006874 active site 1406863006875 catalytic tetrad [active] 1406863006876 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1406863006877 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1406863006878 DNA binding residues [nucleotide binding] 1406863006879 putative dimer interface [polypeptide binding]; other site 1406863006880 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1406863006881 substrate binding site [chemical binding]; other site 1406863006882 catalytic residues [active] 1406863006883 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1406863006884 Peptidase family M23; Region: Peptidase_M23; pfam01551 1406863006885 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1406863006886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1406863006887 active site 1406863006888 motif I; other site 1406863006889 motif II; other site 1406863006890 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1406863006891 acetolactate synthase; Reviewed; Region: PRK08617 1406863006892 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1406863006893 PYR/PP interface [polypeptide binding]; other site 1406863006894 dimer interface [polypeptide binding]; other site 1406863006895 TPP binding site [chemical binding]; other site 1406863006896 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1406863006897 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1406863006898 TPP-binding site [chemical binding]; other site 1406863006899 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1406863006900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863006901 Walker A motif; other site 1406863006902 ATP binding site [chemical binding]; other site 1406863006903 Walker B motif; other site 1406863006904 arginine finger; other site 1406863006905 Predicted helicase [General function prediction only]; Region: COG4889 1406863006906 Predicted helicase [General function prediction only]; Region: COG4889 1406863006907 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1406863006908 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1406863006909 23S rRNA interface [nucleotide binding]; other site 1406863006910 L3 interface [polypeptide binding]; other site 1406863006911 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1406863006912 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1406863006913 dimerization interface 3.5A [polypeptide binding]; other site 1406863006914 active site 1406863006915 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1406863006916 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1406863006917 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1406863006918 Walker A/P-loop; other site 1406863006919 ATP binding site [chemical binding]; other site 1406863006920 Q-loop/lid; other site 1406863006921 ABC transporter signature motif; other site 1406863006922 Walker B; other site 1406863006923 D-loop; other site 1406863006924 H-loop/switch region; other site 1406863006925 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1406863006926 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1406863006927 Walker A/P-loop; other site 1406863006928 ATP binding site [chemical binding]; other site 1406863006929 Q-loop/lid; other site 1406863006930 ABC transporter signature motif; other site 1406863006931 Walker B; other site 1406863006932 D-loop; other site 1406863006933 H-loop/switch region; other site 1406863006934 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1406863006935 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1406863006936 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1406863006937 alphaNTD homodimer interface [polypeptide binding]; other site 1406863006938 alphaNTD - beta interaction site [polypeptide binding]; other site 1406863006939 alphaNTD - beta' interaction site [polypeptide binding]; other site 1406863006940 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1406863006941 30S ribosomal protein S11; Validated; Region: PRK05309 1406863006942 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1406863006943 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1406863006944 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1406863006945 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1406863006946 rRNA binding site [nucleotide binding]; other site 1406863006947 predicted 30S ribosome binding site; other site 1406863006948 adenylate kinase; Reviewed; Region: adk; PRK00279 1406863006949 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1406863006950 AMP-binding site [chemical binding]; other site 1406863006951 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1406863006952 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1406863006953 SecY translocase; Region: SecY; pfam00344 1406863006954 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1406863006955 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1406863006956 23S rRNA binding site [nucleotide binding]; other site 1406863006957 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1406863006958 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1406863006959 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1406863006960 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1406863006961 5S rRNA interface [nucleotide binding]; other site 1406863006962 L27 interface [polypeptide binding]; other site 1406863006963 23S rRNA interface [nucleotide binding]; other site 1406863006964 L5 interface [polypeptide binding]; other site 1406863006965 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1406863006966 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1406863006967 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1406863006968 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1406863006969 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1406863006970 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1406863006971 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1406863006972 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1406863006973 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1406863006974 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1406863006975 RNA binding site [nucleotide binding]; other site 1406863006976 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1406863006977 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1406863006978 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1406863006979 23S rRNA interface [nucleotide binding]; other site 1406863006980 putative translocon interaction site; other site 1406863006981 signal recognition particle (SRP54) interaction site; other site 1406863006982 L23 interface [polypeptide binding]; other site 1406863006983 trigger factor interaction site; other site 1406863006984 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1406863006985 23S rRNA interface [nucleotide binding]; other site 1406863006986 5S rRNA interface [nucleotide binding]; other site 1406863006987 putative antibiotic binding site [chemical binding]; other site 1406863006988 L25 interface [polypeptide binding]; other site 1406863006989 L27 interface [polypeptide binding]; other site 1406863006990 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1406863006991 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1406863006992 G-X-X-G motif; other site 1406863006993 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1406863006994 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1406863006995 putative translocon binding site; other site 1406863006996 protein-rRNA interface [nucleotide binding]; other site 1406863006997 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1406863006998 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1406863006999 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1406863007000 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1406863007001 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1406863007002 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1406863007003 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1406863007004 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1406863007005 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1406863007006 DNA topoisomerase III; Provisional; Region: PRK07726 1406863007007 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1406863007008 active site 1406863007009 putative interdomain interaction site [polypeptide binding]; other site 1406863007010 putative metal-binding site [ion binding]; other site 1406863007011 putative nucleotide binding site [chemical binding]; other site 1406863007012 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1406863007013 domain I; other site 1406863007014 DNA binding groove [nucleotide binding] 1406863007015 phosphate binding site [ion binding]; other site 1406863007016 domain II; other site 1406863007017 domain III; other site 1406863007018 nucleotide binding site [chemical binding]; other site 1406863007019 catalytic site [active] 1406863007020 domain IV; other site 1406863007021 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1406863007022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863007023 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1406863007024 Coenzyme A binding pocket [chemical binding]; other site 1406863007025 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1406863007026 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1406863007027 Predicted permeases [General function prediction only]; Region: COG0679 1406863007028 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1406863007029 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1406863007030 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1406863007031 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1406863007032 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1406863007033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863007035 putative substrate translocation pore; other site 1406863007036 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863007037 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1406863007038 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1406863007039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863007040 FeS/SAM binding site; other site 1406863007041 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1406863007042 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1406863007043 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1406863007044 GTP binding site; other site 1406863007045 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1406863007046 MoaE interaction surface [polypeptide binding]; other site 1406863007047 MoeB interaction surface [polypeptide binding]; other site 1406863007048 thiocarboxylated glycine; other site 1406863007049 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1406863007050 MoaE homodimer interface [polypeptide binding]; other site 1406863007051 MoaD interaction [polypeptide binding]; other site 1406863007052 active site residues [active] 1406863007053 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1406863007054 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1406863007055 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1406863007056 dimer interface [polypeptide binding]; other site 1406863007057 putative functional site; other site 1406863007058 putative MPT binding site; other site 1406863007059 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1406863007060 trimer interface [polypeptide binding]; other site 1406863007061 dimer interface [polypeptide binding]; other site 1406863007062 putative active site [active] 1406863007063 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1406863007064 MPT binding site; other site 1406863007065 trimer interface [polypeptide binding]; other site 1406863007066 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1406863007067 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1406863007068 ATP binding site [chemical binding]; other site 1406863007069 substrate interface [chemical binding]; other site 1406863007070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863007071 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1406863007072 Walker A/P-loop; other site 1406863007073 ATP binding site [chemical binding]; other site 1406863007074 Q-loop/lid; other site 1406863007075 ABC transporter signature motif; other site 1406863007076 Walker B; other site 1406863007077 D-loop; other site 1406863007078 H-loop/switch region; other site 1406863007079 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1406863007080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863007081 dimer interface [polypeptide binding]; other site 1406863007082 conserved gate region; other site 1406863007083 putative PBP binding loops; other site 1406863007084 ABC-ATPase subunit interface; other site 1406863007085 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1406863007086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1406863007087 substrate binding pocket [chemical binding]; other site 1406863007088 membrane-bound complex binding site; other site 1406863007089 hinge residues; other site 1406863007090 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1406863007091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863007092 Coenzyme A binding pocket [chemical binding]; other site 1406863007093 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1406863007094 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1406863007095 active site 1406863007096 dimerization interface [polypeptide binding]; other site 1406863007097 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1406863007098 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1406863007099 intersubunit interface [polypeptide binding]; other site 1406863007100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1406863007101 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1406863007102 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1406863007103 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1406863007104 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1406863007105 alpha-gamma subunit interface [polypeptide binding]; other site 1406863007106 beta-gamma subunit interface [polypeptide binding]; other site 1406863007107 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1406863007108 gamma-beta subunit interface [polypeptide binding]; other site 1406863007109 alpha-beta subunit interface [polypeptide binding]; other site 1406863007110 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1406863007111 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1406863007112 subunit interactions [polypeptide binding]; other site 1406863007113 active site 1406863007114 flap region; other site 1406863007115 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1406863007116 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1406863007117 dimer interface [polypeptide binding]; other site 1406863007118 catalytic residues [active] 1406863007119 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1406863007120 UreF; Region: UreF; pfam01730 1406863007121 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1406863007122 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1406863007123 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863007124 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863007125 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863007126 Helix-turn-helix domain; Region: HTH_18; pfam12833 1406863007127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1406863007128 Surface antigen [General function prediction only]; Region: COG3942 1406863007129 CHAP domain; Region: CHAP; pfam05257 1406863007130 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1406863007131 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1406863007132 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1406863007133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1406863007134 Surface antigen [General function prediction only]; Region: COG3942 1406863007135 CHAP domain; Region: CHAP; pfam05257 1406863007136 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1406863007137 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1406863007138 putative ligand binding site [chemical binding]; other site 1406863007139 putative NAD binding site [chemical binding]; other site 1406863007140 catalytic site [active] 1406863007141 hypothetical protein; Provisional; Region: PRK06753 1406863007142 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1406863007143 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1406863007144 Lysozyme subfamily 2; Region: LYZ2; smart00047 1406863007145 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1406863007146 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1406863007147 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1406863007148 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1406863007149 4Fe-4S binding domain; Region: Fer4; pfam00037 1406863007150 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1406863007151 [4Fe-4S] binding site [ion binding]; other site 1406863007152 molybdopterin cofactor binding site; other site 1406863007153 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1406863007154 molybdopterin cofactor binding site; other site 1406863007155 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1406863007156 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1406863007157 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1406863007158 active site 1406863007159 Predicted transcriptional regulator [Transcription]; Region: COG2378 1406863007160 HTH domain; Region: HTH_11; pfam08279 1406863007161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1406863007162 CAAX protease self-immunity; Region: Abi; pfam02517 1406863007163 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1406863007164 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1406863007165 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1406863007166 putative active site [active] 1406863007167 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1406863007168 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1406863007169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863007170 active site 1406863007171 motif I; other site 1406863007172 motif II; other site 1406863007173 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1406863007174 Sodium Bile acid symporter family; Region: SBF; pfam01758 1406863007175 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1406863007176 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1406863007177 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1406863007178 active site turn [active] 1406863007179 phosphorylation site [posttranslational modification] 1406863007180 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1406863007181 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1406863007182 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1406863007183 putative active site [active] 1406863007184 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1406863007185 putative hydrophobic ligand binding site [chemical binding]; other site 1406863007186 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1406863007187 oxidoreductase; Provisional; Region: PRK07985 1406863007188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1406863007189 NAD(P) binding site [chemical binding]; other site 1406863007190 active site 1406863007191 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1406863007192 amidohydrolase; Region: amidohydrolases; TIGR01891 1406863007193 metal binding site [ion binding]; metal-binding site 1406863007194 dimer interface [polypeptide binding]; other site 1406863007195 imidazolonepropionase; Validated; Region: PRK09356 1406863007196 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1406863007197 active site 1406863007198 urocanate hydratase; Provisional; Region: PRK05414 1406863007199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1406863007200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1406863007201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1406863007202 dimerization interface [polypeptide binding]; other site 1406863007203 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1406863007204 active site 1406863007205 formimidoylglutamase; Provisional; Region: PRK13775 1406863007206 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1406863007207 putative active site [active] 1406863007208 putative metal binding site [ion binding]; other site 1406863007209 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1406863007210 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1406863007211 active site 1406863007212 dimer interface [polypeptide binding]; other site 1406863007213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1406863007214 MOSC domain; Region: MOSC; pfam03473 1406863007215 3-alpha domain; Region: 3-alpha; pfam03475 1406863007216 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1406863007217 active site 1406863007218 catalytic residues [active] 1406863007219 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1406863007220 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1406863007221 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1406863007222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863007223 Walker A/P-loop; other site 1406863007224 ATP binding site [chemical binding]; other site 1406863007225 Q-loop/lid; other site 1406863007226 ABC transporter signature motif; other site 1406863007227 Walker B; other site 1406863007228 D-loop; other site 1406863007229 H-loop/switch region; other site 1406863007230 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1406863007231 Predicted membrane protein [Function unknown]; Region: COG3152 1406863007232 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1406863007233 MULE transposase domain; Region: MULE; pfam10551 1406863007234 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1406863007235 active site 1406863007236 DNA binding site [nucleotide binding] 1406863007237 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1406863007238 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1406863007239 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1406863007240 homotetramer interface [polypeptide binding]; other site 1406863007241 FMN binding site [chemical binding]; other site 1406863007242 homodimer contacts [polypeptide binding]; other site 1406863007243 putative active site [active] 1406863007244 putative substrate binding site [chemical binding]; other site 1406863007245 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1406863007246 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1406863007247 oligomer interface [polypeptide binding]; other site 1406863007248 metal binding site [ion binding]; metal-binding site 1406863007249 metal binding site [ion binding]; metal-binding site 1406863007250 putative Cl binding site [ion binding]; other site 1406863007251 aspartate ring; other site 1406863007252 basic sphincter; other site 1406863007253 hydrophobic gate; other site 1406863007254 periplasmic entrance; other site 1406863007255 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1406863007256 active site 1406863007257 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1406863007258 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1406863007259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007260 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1406863007261 putative substrate translocation pore; other site 1406863007262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007263 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1406863007264 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1406863007265 HlyD family secretion protein; Region: HlyD_3; pfam13437 1406863007266 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1406863007267 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1406863007268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007269 putative substrate translocation pore; other site 1406863007270 Predicted membrane protein [Function unknown]; Region: COG4640 1406863007271 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1406863007272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1406863007273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1406863007274 putative Zn2+ binding site [ion binding]; other site 1406863007275 putative DNA binding site [nucleotide binding]; other site 1406863007276 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1406863007277 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1406863007278 putative active site [active] 1406863007279 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1406863007280 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1406863007281 Walker A/P-loop; other site 1406863007282 ATP binding site [chemical binding]; other site 1406863007283 Q-loop/lid; other site 1406863007284 ABC transporter signature motif; other site 1406863007285 Walker B; other site 1406863007286 D-loop; other site 1406863007287 H-loop/switch region; other site 1406863007288 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1406863007289 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1406863007290 FtsX-like permease family; Region: FtsX; pfam02687 1406863007291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1406863007292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863007293 active site 1406863007294 phosphorylation site [posttranslational modification] 1406863007295 intermolecular recognition site; other site 1406863007296 dimerization interface [polypeptide binding]; other site 1406863007297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1406863007298 DNA binding site [nucleotide binding] 1406863007299 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1406863007300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1406863007301 dimerization interface [polypeptide binding]; other site 1406863007302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1406863007303 dimer interface [polypeptide binding]; other site 1406863007304 phosphorylation site [posttranslational modification] 1406863007305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863007306 ATP binding site [chemical binding]; other site 1406863007307 Mg2+ binding site [ion binding]; other site 1406863007308 G-X-G motif; other site 1406863007309 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1406863007310 LytTr DNA-binding domain; Region: LytTR; smart00850 1406863007311 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1406863007312 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 1406863007313 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1406863007314 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1406863007315 L-lactate permease; Region: Lactate_perm; cl00701 1406863007316 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1406863007317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863007318 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1406863007319 Coenzyme A binding pocket [chemical binding]; other site 1406863007320 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1406863007321 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1406863007322 NAD(P) binding site [chemical binding]; other site 1406863007323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863007324 Coenzyme A binding pocket [chemical binding]; other site 1406863007325 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1406863007326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1406863007327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863007328 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1406863007329 Predicted membrane protein [Function unknown]; Region: COG1511 1406863007330 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1406863007331 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1406863007332 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1406863007333 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1406863007334 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1406863007335 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1406863007336 Cl binding site [ion binding]; other site 1406863007337 oligomer interface [polypeptide binding]; other site 1406863007338 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1406863007339 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1406863007340 active site turn [active] 1406863007341 phosphorylation site [posttranslational modification] 1406863007342 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1406863007343 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1406863007344 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1406863007345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1406863007346 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1406863007347 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1406863007348 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1406863007349 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1406863007350 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1406863007351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1406863007352 MarR family; Region: MarR_2; pfam12802 1406863007353 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1406863007354 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1406863007355 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1406863007356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007357 putative substrate translocation pore; other site 1406863007358 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1406863007359 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1406863007360 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1406863007361 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1406863007362 DNA binding residues [nucleotide binding] 1406863007363 dimer interface [polypeptide binding]; other site 1406863007364 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1406863007365 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1406863007366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863007367 active site 1406863007368 phosphorylation site [posttranslational modification] 1406863007369 intermolecular recognition site; other site 1406863007370 dimerization interface [polypeptide binding]; other site 1406863007371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1406863007372 DNA binding residues [nucleotide binding] 1406863007373 dimerization interface [polypeptide binding]; other site 1406863007374 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1406863007375 Histidine kinase; Region: HisKA_3; pfam07730 1406863007376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863007377 ATP binding site [chemical binding]; other site 1406863007378 Mg2+ binding site [ion binding]; other site 1406863007379 G-X-G motif; other site 1406863007380 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1406863007381 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1406863007382 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1406863007383 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1406863007384 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1406863007385 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1406863007386 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1406863007387 [4Fe-4S] binding site [ion binding]; other site 1406863007388 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1406863007389 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1406863007390 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1406863007391 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1406863007392 molybdopterin cofactor binding site; other site 1406863007393 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1406863007394 active site 1406863007395 SAM binding site [chemical binding]; other site 1406863007396 homodimer interface [polypeptide binding]; other site 1406863007397 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1406863007398 [2Fe-2S] cluster binding site [ion binding]; other site 1406863007399 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1406863007400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1406863007401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863007402 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1406863007403 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1406863007404 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1406863007405 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1406863007406 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1406863007407 putative active site [active] 1406863007408 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1406863007409 active site 1406863007410 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1406863007411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863007412 Coenzyme A binding pocket [chemical binding]; other site 1406863007413 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1406863007414 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1406863007415 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1406863007416 putative hydrophobic ligand binding site [chemical binding]; other site 1406863007417 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1406863007418 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1406863007419 intersubunit interface [polypeptide binding]; other site 1406863007420 YodA lipocalin-like domain; Region: YodA; pfam09223 1406863007421 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1406863007422 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1406863007423 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1406863007424 Thioredoxin; Region: Thioredoxin_4; cl17273 1406863007425 FemAB family; Region: FemAB; pfam02388 1406863007426 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1406863007427 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1406863007428 Walker A/P-loop; other site 1406863007429 ATP binding site [chemical binding]; other site 1406863007430 Q-loop/lid; other site 1406863007431 ABC transporter signature motif; other site 1406863007432 Walker B; other site 1406863007433 D-loop; other site 1406863007434 H-loop/switch region; other site 1406863007435 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1406863007436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863007437 dimer interface [polypeptide binding]; other site 1406863007438 conserved gate region; other site 1406863007439 putative PBP binding loops; other site 1406863007440 ABC-ATPase subunit interface; other site 1406863007441 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1406863007442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1406863007443 substrate binding pocket [chemical binding]; other site 1406863007444 membrane-bound complex binding site; other site 1406863007445 hinge residues; other site 1406863007446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863007448 putative substrate translocation pore; other site 1406863007449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007450 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1406863007451 catalytic core [active] 1406863007452 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1406863007453 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1406863007454 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1406863007455 B domain; Region: B; pfam02216 1406863007456 B domain; Region: B; pfam02216 1406863007457 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 1406863007458 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1406863007459 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1406863007460 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1406863007461 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1406863007462 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1406863007463 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1406863007464 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1406863007465 catalytic residue [active] 1406863007466 biotin synthase; Validated; Region: PRK06256 1406863007467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863007468 FeS/SAM binding site; other site 1406863007469 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1406863007470 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1406863007471 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1406863007472 inhibitor-cofactor binding pocket; inhibition site 1406863007473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863007474 catalytic residue [active] 1406863007475 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1406863007476 AAA domain; Region: AAA_26; pfam13500 1406863007477 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1406863007478 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1406863007479 Walker A/P-loop; other site 1406863007480 ATP binding site [chemical binding]; other site 1406863007481 Q-loop/lid; other site 1406863007482 ABC transporter signature motif; other site 1406863007483 Walker B; other site 1406863007484 D-loop; other site 1406863007485 H-loop/switch region; other site 1406863007486 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1406863007487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1406863007488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863007489 Walker A/P-loop; other site 1406863007490 ATP binding site [chemical binding]; other site 1406863007491 Q-loop/lid; other site 1406863007492 ABC transporter signature motif; other site 1406863007493 Walker B; other site 1406863007494 D-loop; other site 1406863007495 H-loop/switch region; other site 1406863007496 Predicted membrane protein [Function unknown]; Region: COG2246 1406863007497 GtrA-like protein; Region: GtrA; pfam04138 1406863007498 glycerate kinase; Region: TIGR00045 1406863007499 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1406863007500 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1406863007501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007502 putative substrate translocation pore; other site 1406863007503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1406863007504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1406863007505 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1406863007506 putative phosphoesterase; Region: acc_ester; TIGR03729 1406863007507 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1406863007508 Spore germination protein; Region: Spore_permease; cl17796 1406863007509 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1406863007510 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1406863007511 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1406863007512 Beta-lactamase; Region: Beta-lactamase; pfam00144 1406863007513 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1406863007514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1406863007515 NAD(P) binding site [chemical binding]; other site 1406863007516 active site 1406863007517 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1406863007518 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1406863007519 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1406863007520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007521 putative substrate translocation pore; other site 1406863007522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863007524 dimer interface [polypeptide binding]; other site 1406863007525 conserved gate region; other site 1406863007526 ABC-ATPase subunit interface; other site 1406863007527 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1406863007528 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1406863007529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863007530 dimer interface [polypeptide binding]; other site 1406863007531 conserved gate region; other site 1406863007532 putative PBP binding loops; other site 1406863007533 ABC-ATPase subunit interface; other site 1406863007534 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1406863007535 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1406863007536 Walker A/P-loop; other site 1406863007537 ATP binding site [chemical binding]; other site 1406863007538 Q-loop/lid; other site 1406863007539 ABC transporter signature motif; other site 1406863007540 Walker B; other site 1406863007541 D-loop; other site 1406863007542 H-loop/switch region; other site 1406863007543 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1406863007544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1406863007545 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1406863007546 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1406863007547 amino acid transporter; Region: 2A0306; TIGR00909 1406863007548 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1406863007549 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1406863007550 substrate binding pocket [chemical binding]; other site 1406863007551 catalytic triad [active] 1406863007552 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1406863007553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007554 putative substrate translocation pore; other site 1406863007555 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1406863007556 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1406863007557 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1406863007558 Walker A/P-loop; other site 1406863007559 ATP binding site [chemical binding]; other site 1406863007560 Q-loop/lid; other site 1406863007561 ABC transporter signature motif; other site 1406863007562 Walker B; other site 1406863007563 D-loop; other site 1406863007564 H-loop/switch region; other site 1406863007565 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1406863007566 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1406863007567 oligomer interface [polypeptide binding]; other site 1406863007568 active site 1406863007569 metal binding site [ion binding]; metal-binding site 1406863007570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 1406863007571 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1406863007572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1406863007573 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1406863007574 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1406863007575 active site 1406863007576 FMN binding site [chemical binding]; other site 1406863007577 substrate binding site [chemical binding]; other site 1406863007578 3Fe-4S cluster binding site [ion binding]; other site 1406863007579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863007581 putative substrate translocation pore; other site 1406863007582 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1406863007583 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863007584 Walker A/P-loop; other site 1406863007585 ATP binding site [chemical binding]; other site 1406863007586 Q-loop/lid; other site 1406863007587 ABC transporter signature motif; other site 1406863007588 Walker B; other site 1406863007589 D-loop; other site 1406863007590 H-loop/switch region; other site 1406863007591 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1406863007592 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1406863007593 Walker A/P-loop; other site 1406863007594 ATP binding site [chemical binding]; other site 1406863007595 Q-loop/lid; other site 1406863007596 ABC transporter signature motif; other site 1406863007597 Walker B; other site 1406863007598 D-loop; other site 1406863007599 H-loop/switch region; other site 1406863007600 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1406863007601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1406863007602 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1406863007603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863007604 dimer interface [polypeptide binding]; other site 1406863007605 conserved gate region; other site 1406863007606 ABC-ATPase subunit interface; other site 1406863007607 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1406863007608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1406863007609 dimer interface [polypeptide binding]; other site 1406863007610 conserved gate region; other site 1406863007611 putative PBP binding loops; other site 1406863007612 ABC-ATPase subunit interface; other site 1406863007613 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1406863007614 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1406863007615 substrate binding site [chemical binding]; other site 1406863007616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1406863007617 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1406863007618 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1406863007619 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1406863007620 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1406863007621 classical (c) SDRs; Region: SDR_c; cd05233 1406863007622 NAD(P) binding site [chemical binding]; other site 1406863007623 active site 1406863007624 AbgT putative transporter family; Region: ABG_transport; pfam03806 1406863007625 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1406863007626 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1406863007627 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1406863007628 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1406863007629 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1406863007630 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1406863007631 classical (c) SDRs; Region: SDR_c; cd05233 1406863007632 NAD(P) binding site [chemical binding]; other site 1406863007633 active site 1406863007634 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1406863007635 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1406863007636 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1406863007637 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1406863007638 PLD-like domain; Region: PLDc_2; pfam13091 1406863007639 putative homodimer interface [polypeptide binding]; other site 1406863007640 putative active site [active] 1406863007641 catalytic site [active] 1406863007642 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1406863007643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1406863007644 ATP binding site [chemical binding]; other site 1406863007645 putative Mg++ binding site [ion binding]; other site 1406863007646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1406863007647 nucleotide binding region [chemical binding]; other site 1406863007648 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1406863007649 ATP-binding site [chemical binding]; other site 1406863007650 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1406863007651 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1406863007652 active site 1406863007653 8-oxo-dGMP binding site [chemical binding]; other site 1406863007654 nudix motif; other site 1406863007655 metal binding site [ion binding]; metal-binding site 1406863007656 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1406863007657 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1406863007658 active site 1406863007659 substrate binding site [chemical binding]; other site 1406863007660 metal binding site [ion binding]; metal-binding site 1406863007661 H+ Antiporter protein; Region: 2A0121; TIGR00900 1406863007662 legume lectins; Region: lectin_L-type; cl14058 1406863007663 homotetramer interaction site [polypeptide binding]; other site 1406863007664 carbohydrate binding site [chemical binding]; other site 1406863007665 metal binding site [ion binding]; metal-binding site 1406863007666 G5 domain; Region: G5; pfam07501 1406863007667 G5 domain; Region: G5; pfam07501 1406863007668 G5 domain; Region: G5; pfam07501 1406863007669 G5 domain; Region: G5; pfam07501 1406863007670 G5 domain; Region: G5; pfam07501 1406863007671 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1406863007672 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863007673 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863007674 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1406863007675 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863007676 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1406863007677 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1406863007678 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1406863007679 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1406863007680 active site 1406863007681 tetramer interface; other site 1406863007682 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1406863007683 Fibronectin binding repeat; Region: Fn_bind; pfam02986 1406863007684 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1406863007685 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1406863007686 Fibronectin binding repeat; Region: Fn_bind; pfam02986 1406863007687 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1406863007688 GntP family permease; Region: GntP_permease; pfam02447 1406863007689 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1406863007690 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1406863007691 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1406863007692 N- and C-terminal domain interface [polypeptide binding]; other site 1406863007693 active site 1406863007694 catalytic site [active] 1406863007695 metal binding site [ion binding]; metal-binding site 1406863007696 carbohydrate binding site [chemical binding]; other site 1406863007697 ATP binding site [chemical binding]; other site 1406863007698 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1406863007699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1406863007700 DNA-binding site [nucleotide binding]; DNA binding site 1406863007701 FCD domain; Region: FCD; pfam07729 1406863007702 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1406863007703 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1406863007704 DNA binding residues [nucleotide binding] 1406863007705 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1406863007706 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1406863007707 synthetase active site [active] 1406863007708 NTP binding site [chemical binding]; other site 1406863007709 metal binding site [ion binding]; metal-binding site 1406863007710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1406863007711 Predicted membrane protein [Function unknown]; Region: COG1289 1406863007712 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1406863007713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007714 D-galactonate transporter; Region: 2A0114; TIGR00893 1406863007715 putative substrate translocation pore; other site 1406863007716 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1406863007717 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1406863007718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863007719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863007720 putative substrate translocation pore; other site 1406863007721 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1406863007722 MarR family; Region: MarR; pfam01047 1406863007723 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1406863007724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863007725 Walker A/P-loop; other site 1406863007726 ATP binding site [chemical binding]; other site 1406863007727 Q-loop/lid; other site 1406863007728 ABC transporter signature motif; other site 1406863007729 Walker B; other site 1406863007730 D-loop; other site 1406863007731 H-loop/switch region; other site 1406863007732 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1406863007733 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1406863007734 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 1406863007735 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1406863007736 Predicted esterase [General function prediction only]; Region: COG0400 1406863007737 putative hydrolase; Provisional; Region: PRK11460 1406863007738 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1406863007739 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1406863007740 Zn binding site [ion binding]; other site 1406863007741 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1406863007742 Zn binding site [ion binding]; other site 1406863007743 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1406863007744 MarR family; Region: MarR; pfam01047 1406863007745 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1406863007746 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1406863007747 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1406863007748 putative metal binding site [ion binding]; other site 1406863007749 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1406863007750 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1406863007751 dimer interface [polypeptide binding]; other site 1406863007752 FMN binding site [chemical binding]; other site 1406863007753 D-lactate dehydrogenase; Provisional; Region: PRK12480 1406863007754 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1406863007755 homodimer interface [polypeptide binding]; other site 1406863007756 ligand binding site [chemical binding]; other site 1406863007757 NAD binding site [chemical binding]; other site 1406863007758 catalytic site [active] 1406863007759 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1406863007760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1406863007761 active site 1406863007762 motif I; other site 1406863007763 motif II; other site 1406863007764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1406863007765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1406863007766 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1406863007767 Walker A/P-loop; other site 1406863007768 ATP binding site [chemical binding]; other site 1406863007769 Q-loop/lid; other site 1406863007770 ABC transporter signature motif; other site 1406863007771 Walker B; other site 1406863007772 D-loop; other site 1406863007773 H-loop/switch region; other site 1406863007774 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1406863007775 active site 1406863007776 catalytic site [active] 1406863007777 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1406863007778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863007779 Coenzyme A binding pocket [chemical binding]; other site 1406863007780 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1406863007781 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1406863007782 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1406863007783 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1406863007784 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1406863007785 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1406863007786 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1406863007787 EamA-like transporter family; Region: EamA; pfam00892 1406863007788 EamA-like transporter family; Region: EamA; pfam00892 1406863007789 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1406863007790 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1406863007791 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1406863007792 catalytic residues [active] 1406863007793 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1406863007794 active site 1406863007795 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1406863007796 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1406863007797 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1406863007798 active site turn [active] 1406863007799 phosphorylation site [posttranslational modification] 1406863007800 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1406863007801 HPr interaction site; other site 1406863007802 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1406863007803 active site 1406863007804 phosphorylation site [posttranslational modification] 1406863007805 pyruvate oxidase; Provisional; Region: PRK08611 1406863007806 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1406863007807 PYR/PP interface [polypeptide binding]; other site 1406863007808 tetramer interface [polypeptide binding]; other site 1406863007809 dimer interface [polypeptide binding]; other site 1406863007810 TPP binding site [chemical binding]; other site 1406863007811 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1406863007812 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1406863007813 TPP-binding site [chemical binding]; other site 1406863007814 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1406863007815 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1406863007816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1406863007817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1406863007818 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1406863007819 putative dimerization interface [polypeptide binding]; other site 1406863007820 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1406863007821 Surface antigen [General function prediction only]; Region: COG3942 1406863007822 CHAP domain; Region: CHAP; pfam05257 1406863007823 Replication protein; Region: Rep_1; cl02412 1406863007824 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1406863007825 homodimer interface [polypeptide binding]; other site 1406863007826 catalytic residues [active] 1406863007827 NAD binding site [chemical binding]; other site 1406863007828 substrate binding pocket [chemical binding]; other site 1406863007829 flexible flap; other site 1406863007830 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1406863007831 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1406863007832 dimer interface [polypeptide binding]; other site 1406863007833 active site 1406863007834 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1406863007835 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1406863007836 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1406863007837 DNA binding site [nucleotide binding] 1406863007838 active site 1406863007839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863007840 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1406863007841 Walker A motif; other site 1406863007842 ATP binding site [chemical binding]; other site 1406863007843 Walker B motif; other site 1406863007844 arginine finger; other site 1406863007845 UvrB/uvrC motif; Region: UVR; pfam02151 1406863007846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1406863007847 Walker A motif; other site 1406863007848 ATP binding site [chemical binding]; other site 1406863007849 Walker B motif; other site 1406863007850 arginine finger; other site 1406863007851 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1406863007852 Virus attachment protein p12 family; Region: P12; pfam12669 1406863007853 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1406863007854 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1406863007855 G1 box; other site 1406863007856 GTP/Mg2+ binding site [chemical binding]; other site 1406863007857 Switch I region; other site 1406863007858 G2 box; other site 1406863007859 G3 box; other site 1406863007860 Switch II region; other site 1406863007861 G4 box; other site 1406863007862 G5 box; other site 1406863007863 Nucleoside recognition; Region: Gate; pfam07670 1406863007864 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1406863007865 Nucleoside recognition; Region: Gate; pfam07670 1406863007866 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1406863007867 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1406863007868 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1406863007869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1406863007870 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1406863007871 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1406863007872 Glutamate binding site [chemical binding]; other site 1406863007873 homodimer interface [polypeptide binding]; other site 1406863007874 NAD binding site [chemical binding]; other site 1406863007875 catalytic residues [active] 1406863007876 maltose O-acetyltransferase; Provisional; Region: PRK10092 1406863007877 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1406863007878 active site 1406863007879 substrate binding site [chemical binding]; other site 1406863007880 trimer interface [polypeptide binding]; other site 1406863007881 CoA binding site [chemical binding]; other site 1406863007882 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1406863007883 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1406863007884 metal-binding site [ion binding] 1406863007885 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1406863007886 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1406863007887 metal-binding site [ion binding] 1406863007888 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1406863007889 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1406863007890 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1406863007891 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1406863007892 metal-binding site [ion binding] 1406863007893 D-lactate dehydrogenase; Validated; Region: PRK08605 1406863007894 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1406863007895 homodimer interface [polypeptide binding]; other site 1406863007896 ligand binding site [chemical binding]; other site 1406863007897 NAD binding site [chemical binding]; other site 1406863007898 catalytic site [active] 1406863007899 transaminase; Reviewed; Region: PRK08068 1406863007900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1406863007901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863007902 homodimer interface [polypeptide binding]; other site 1406863007903 catalytic residue [active] 1406863007904 phytoene desaturase; Region: crtI_fam; TIGR02734 1406863007905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1406863007906 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1406863007907 active site lid residues [active] 1406863007908 substrate binding pocket [chemical binding]; other site 1406863007909 catalytic residues [active] 1406863007910 substrate-Mg2+ binding site; other site 1406863007911 aspartate-rich region 1; other site 1406863007912 aspartate-rich region 2; other site 1406863007913 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1406863007914 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1406863007915 active site 1406863007916 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1406863007917 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1406863007918 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 1406863007919 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1406863007920 Surface antigen [General function prediction only]; Region: COG3942 1406863007921 CHAP domain; Region: CHAP; pfam05257 1406863007922 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1406863007923 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1406863007924 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1406863007925 catalytic triad [active] 1406863007926 catalytic triad [active] 1406863007927 oxyanion hole [active] 1406863007928 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1406863007929 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1406863007930 catalytic residue [active] 1406863007931 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1406863007932 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1406863007933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1406863007934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1406863007935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1406863007936 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1406863007937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1406863007938 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1406863007939 NmrA-like family; Region: NmrA; pfam05368 1406863007940 NADP binding site [chemical binding]; other site 1406863007941 active site 1406863007942 regulatory binding site [polypeptide binding]; other site 1406863007943 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 1406863007944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1406863007945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1406863007946 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1406863007947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1406863007948 NAD(P) binding site [chemical binding]; other site 1406863007949 active site 1406863007950 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1406863007951 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1406863007952 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1406863007953 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1406863007954 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1406863007955 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1406863007956 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1406863007957 Nucleoside recognition; Region: Gate; pfam07670 1406863007958 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1406863007959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1406863007960 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1406863007961 Integrase core domain; Region: rve; pfam00665 1406863007962 Class I aldolases; Region: Aldolase_Class_I; cl17187 1406863007963 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 1406863007964 Helix-turn-helix domain; Region: HTH_28; pfam13518 1406863007965 Winged helix-turn helix; Region: HTH_29; pfam13551 1406863007966 Integrase core domain; Region: rve; pfam00665 1406863007967 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1406863007968 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1406863007969 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1406863007970 catalytic residues [active] 1406863007971 catalytic nucleophile [active] 1406863007972 Presynaptic Site I dimer interface [polypeptide binding]; other site 1406863007973 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1406863007974 Synaptic Flat tetramer interface [polypeptide binding]; other site 1406863007975 Synaptic Site I dimer interface [polypeptide binding]; other site 1406863007976 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1406863007977 DNA-binding interface [nucleotide binding]; DNA binding site 1406863007978 Predicted transcriptional regulator [Transcription]; Region: COG3682 1406863007979 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1406863007980 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1406863007981 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1406863007982 beta-lactamase TEM; Provisional; Region: PRK15442 1406863007983 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1406863007984 Winged helix-turn helix; Region: HTH_29; pfam13551 1406863007985 Homeodomain-like domain; Region: HTH_32; pfam13565 1406863007986 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1406863007987 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1406863007988 Surface antigen [General function prediction only]; Region: COG3942 1406863007989 CHAP domain; Region: CHAP; pfam05257 1406863007990 ribonuclease E; Reviewed; Region: rne; PRK10811 1406863007991 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1406863007992 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1406863007993 AAA-like domain; Region: AAA_10; pfam12846 1406863007994 TcpE family; Region: TcpE; pfam12648 1406863007995 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1406863007996 Replication initiation factor; Region: Rep_trans; pfam02486 1406863007997 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1406863007998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 1406863007999 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1406863008000 Phosphotransferase enzyme family; Region: APH; pfam01636 1406863008001 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1406863008002 active site 1406863008003 ATP binding site [chemical binding]; other site 1406863008004 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1406863008005 active site 1406863008006 ATP binding site [chemical binding]; other site 1406863008007 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1406863008008 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1406863008009 quinone interaction residues [chemical binding]; other site 1406863008010 active site 1406863008011 catalytic residues [active] 1406863008012 FMN binding site [chemical binding]; other site 1406863008013 substrate binding site [chemical binding]; other site 1406863008014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1406863008015 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1406863008016 dimer interface [polypeptide binding]; other site 1406863008017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1406863008018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1406863008019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1406863008020 Predicted acyl esterases [General function prediction only]; Region: COG2936 1406863008021 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1406863008022 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1406863008023 tetramerization interface [polypeptide binding]; other site 1406863008024 active site 1406863008025 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1406863008026 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1406863008027 active site 1406863008028 ATP-binding site [chemical binding]; other site 1406863008029 pantoate-binding site; other site 1406863008030 HXXH motif; other site 1406863008031 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1406863008032 oligomerization interface [polypeptide binding]; other site 1406863008033 active site 1406863008034 metal binding site [ion binding]; metal-binding site 1406863008035 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1406863008036 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1406863008037 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1406863008038 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1406863008039 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1406863008040 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1406863008041 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1406863008042 NAD binding site [chemical binding]; other site 1406863008043 dimer interface [polypeptide binding]; other site 1406863008044 substrate binding site [chemical binding]; other site 1406863008045 amino acid transporter; Region: 2A0306; TIGR00909 1406863008046 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1406863008047 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1406863008048 inhibitor-cofactor binding pocket; inhibition site 1406863008049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863008050 catalytic residue [active] 1406863008051 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1406863008052 catalytic residue [active] 1406863008053 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1406863008054 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1406863008055 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1406863008056 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1406863008057 acyl-activating enzyme (AAE) consensus motif; other site 1406863008058 AMP binding site [chemical binding]; other site 1406863008059 active site 1406863008060 CoA binding site [chemical binding]; other site 1406863008061 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1406863008062 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1406863008063 choline dehydrogenase; Validated; Region: PRK02106 1406863008064 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1406863008065 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1406863008066 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1406863008067 tetramerization interface [polypeptide binding]; other site 1406863008068 NAD(P) binding site [chemical binding]; other site 1406863008069 catalytic residues [active] 1406863008070 Predicted transcriptional regulators [Transcription]; Region: COG1510 1406863008071 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1406863008072 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1406863008073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1406863008074 FeS/SAM binding site; other site 1406863008075 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1406863008076 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1406863008077 effector binding site; other site 1406863008078 active site 1406863008079 Zn binding site [ion binding]; other site 1406863008080 glycine loop; other site 1406863008081 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1406863008082 Citrate transporter; Region: CitMHS; pfam03600 1406863008083 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1406863008084 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1406863008085 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1406863008086 Flavodoxin; Region: Flavodoxin_1; pfam00258 1406863008087 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1406863008088 FAD binding pocket [chemical binding]; other site 1406863008089 FAD binding motif [chemical binding]; other site 1406863008090 catalytic residues [active] 1406863008091 NAD binding pocket [chemical binding]; other site 1406863008092 phosphate binding motif [ion binding]; other site 1406863008093 beta-alpha-beta structure motif; other site 1406863008094 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1406863008095 catalytic residues [active] 1406863008096 dimer interface [polypeptide binding]; other site 1406863008097 FtsX-like permease family; Region: FtsX; pfam02687 1406863008098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1406863008099 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1406863008100 Walker A/P-loop; other site 1406863008101 ATP binding site [chemical binding]; other site 1406863008102 Q-loop/lid; other site 1406863008103 ABC transporter signature motif; other site 1406863008104 Walker B; other site 1406863008105 D-loop; other site 1406863008106 H-loop/switch region; other site 1406863008107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1406863008108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1406863008109 ATP binding site [chemical binding]; other site 1406863008110 Mg2+ binding site [ion binding]; other site 1406863008111 G-X-G motif; other site 1406863008112 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1406863008113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1406863008114 active site 1406863008115 phosphorylation site [posttranslational modification] 1406863008116 intermolecular recognition site; other site 1406863008117 dimerization interface [polypeptide binding]; other site 1406863008118 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1406863008119 DNA binding site [nucleotide binding] 1406863008120 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1406863008121 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1406863008122 dimer interface [polypeptide binding]; other site 1406863008123 active site 1406863008124 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1406863008125 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1406863008126 MarR family; Region: MarR_2; pfam12802 1406863008127 Predicted esterase [General function prediction only]; Region: COG0627 1406863008128 S-formylglutathione hydrolase; Region: PLN02442 1406863008129 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1406863008130 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1406863008131 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1406863008132 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1406863008133 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1406863008134 ligand binding site [chemical binding]; other site 1406863008135 flexible hinge region; other site 1406863008136 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1406863008137 carbamate kinase; Reviewed; Region: PRK12686 1406863008138 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1406863008139 putative substrate binding site [chemical binding]; other site 1406863008140 nucleotide binding site [chemical binding]; other site 1406863008141 nucleotide binding site [chemical binding]; other site 1406863008142 homodimer interface [polypeptide binding]; other site 1406863008143 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1406863008144 ornithine carbamoyltransferase; Validated; Region: PRK02102 1406863008145 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1406863008146 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1406863008147 arginine deiminase; Provisional; Region: PRK01388 1406863008148 Arginine repressor [Transcription]; Region: ArgR; COG1438 1406863008149 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1406863008150 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1406863008151 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1406863008152 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1406863008153 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1406863008154 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1406863008155 active site 1406863008156 Zn binding site [ion binding]; other site 1406863008157 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1406863008158 HTH domain; Region: HTH_11; pfam08279 1406863008159 PRD domain; Region: PRD; pfam00874 1406863008160 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1406863008161 active site 1406863008162 P-loop; other site 1406863008163 phosphorylation site [posttranslational modification] 1406863008164 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1406863008165 active site 1406863008166 phosphorylation site [posttranslational modification] 1406863008167 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1406863008168 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1406863008169 active site 1406863008170 P-loop; other site 1406863008171 phosphorylation site [posttranslational modification] 1406863008172 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1406863008173 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1406863008174 active site 1406863008175 phosphorylation site [posttranslational modification] 1406863008176 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1406863008177 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1406863008178 Predicted membrane protein [Function unknown]; Region: COG1511 1406863008179 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1406863008180 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1406863008181 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1406863008182 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1406863008183 CHAP domain; Region: CHAP; pfam05257 1406863008184 Isochorismatase family; Region: Isochorismatase; pfam00857 1406863008185 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1406863008186 catalytic triad [active] 1406863008187 conserved cis-peptide bond; other site 1406863008188 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1406863008189 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1406863008190 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1406863008191 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1406863008192 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1406863008193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1406863008194 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1406863008195 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1406863008196 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1406863008197 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1406863008198 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1406863008199 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1406863008200 SecY translocase; Region: SecY; pfam00344 1406863008201 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1406863008202 legume lectins; Region: lectin_L-type; cd01951 1406863008203 homotetramer interaction site [polypeptide binding]; other site 1406863008204 carbohydrate binding site [chemical binding]; other site 1406863008205 metal binding site [ion binding]; metal-binding site 1406863008206 Putative Ig domain; Region: He_PIG; pfam05345 1406863008207 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1406863008208 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1406863008209 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1406863008210 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1406863008211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1406863008212 Coenzyme A binding pocket [chemical binding]; other site 1406863008213 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1406863008214 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1406863008215 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1406863008216 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1406863008217 Chain length determinant protein; Region: Wzz; cl15801 1406863008218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1406863008219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1406863008220 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1406863008221 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1406863008222 DXD motif; other site 1406863008223 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 1406863008224 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 1406863008225 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1406863008226 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1406863008227 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1406863008228 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1406863008229 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1406863008230 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1406863008231 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1406863008232 metal binding site [ion binding]; metal-binding site 1406863008233 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1406863008234 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1406863008235 substrate binding site [chemical binding]; other site 1406863008236 glutamase interaction surface [polypeptide binding]; other site 1406863008237 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1406863008238 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1406863008239 catalytic residues [active] 1406863008240 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1406863008241 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1406863008242 putative active site [active] 1406863008243 oxyanion strand; other site 1406863008244 catalytic triad [active] 1406863008245 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1406863008246 putative active site pocket [active] 1406863008247 4-fold oligomerization interface [polypeptide binding]; other site 1406863008248 metal binding residues [ion binding]; metal-binding site 1406863008249 3-fold/trimer interface [polypeptide binding]; other site 1406863008250 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1406863008251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1406863008252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1406863008253 homodimer interface [polypeptide binding]; other site 1406863008254 catalytic residue [active] 1406863008255 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1406863008256 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1406863008257 NAD binding site [chemical binding]; other site 1406863008258 dimerization interface [polypeptide binding]; other site 1406863008259 product binding site; other site 1406863008260 substrate binding site [chemical binding]; other site 1406863008261 zinc binding site [ion binding]; other site 1406863008262 catalytic residues [active] 1406863008263 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 1406863008264 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1406863008265 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1406863008266 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1406863008267 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1406863008268 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1406863008269 putative active site [active] 1406863008270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1406863008271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1406863008272 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1406863008273 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1406863008274 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1406863008275 Walker A/P-loop; other site 1406863008276 ATP binding site [chemical binding]; other site 1406863008277 Q-loop/lid; other site 1406863008278 ABC transporter signature motif; other site 1406863008279 Walker B; other site 1406863008280 D-loop; other site 1406863008281 H-loop/switch region; other site 1406863008282 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1406863008283 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1406863008284 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1406863008285 Walker A/P-loop; other site 1406863008286 ATP binding site [chemical binding]; other site 1406863008287 Q-loop/lid; other site 1406863008288 ABC transporter signature motif; other site 1406863008289 Walker B; other site 1406863008290 D-loop; other site 1406863008291 H-loop/switch region; other site 1406863008292 hypothetical protein; Provisional; Region: PRK13661 1406863008293 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1406863008294 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1406863008295 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1406863008296 Strictosidine synthase; Region: Str_synth; pfam03088 1406863008297 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1406863008298 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1406863008299 active site residue [active] 1406863008300 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1406863008301 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1406863008302 putative substrate binding pocket [chemical binding]; other site 1406863008303 AC domain interface; other site 1406863008304 catalytic triad [active] 1406863008305 AB domain interface; other site 1406863008306 interchain disulfide; other site 1406863008307 DinB superfamily; Region: DinB_2; pfam12867 1406863008308 Collagen binding domain; Region: Collagen_bind; pfam05737 1406863008309 Cna protein B-type domain; Region: Cna_B; pfam05738 1406863008310 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1406863008311 domain interaction interfaces [polypeptide binding]; other site 1406863008312 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1406863008313 domain interaction interfaces [polypeptide binding]; other site 1406863008314 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1406863008315 domain interaction interfaces [polypeptide binding]; other site 1406863008316 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1406863008317 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1406863008318 transmembrane helices; other site 1406863008319 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1406863008320 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1406863008321 hypothetical protein; Provisional; Region: PRK07758 1406863008322 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1406863008323 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1406863008324 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1406863008325 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1406863008326 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1406863008327 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1406863008328 Walker A/P-loop; other site 1406863008329 ATP binding site [chemical binding]; other site 1406863008330 Q-loop/lid; other site 1406863008331 ABC transporter signature motif; other site 1406863008332 Walker B; other site 1406863008333 D-loop; other site 1406863008334 H-loop/switch region; other site 1406863008335 FtsX-like permease family; Region: FtsX; pfam02687 1406863008336 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1406863008337 Integrase core domain; Region: rve; pfam00665 1406863008338 Integrase core domain; Region: rve_3; cl15866 1406863008339 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1406863008340 active site 1406863008341 catalytic residues [active] 1406863008342 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1406863008343 DNA-binding site [nucleotide binding]; DNA binding site 1406863008344 RNA-binding motif; other site 1406863008345 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1406863008346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863008347 non-specific DNA binding site [nucleotide binding]; other site 1406863008348 salt bridge; other site 1406863008349 sequence-specific DNA binding site [nucleotide binding]; other site 1406863008350 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1406863008351 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1406863008352 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1406863008353 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1406863008354 ParB-like nuclease domain; Region: ParBc; pfam02195 1406863008355 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1406863008356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1406863008357 S-adenosylmethionine binding site [chemical binding]; other site 1406863008358 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1406863008359 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1406863008360 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1406863008361 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1406863008362 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1406863008363 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1406863008364 G1 box; other site 1406863008365 GTP/Mg2+ binding site [chemical binding]; other site 1406863008366 Switch I region; other site 1406863008367 G2 box; other site 1406863008368 Switch II region; other site 1406863008369 G3 box; other site 1406863008370 G4 box; other site 1406863008371 G5 box; other site 1406863008372 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1406863008373 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1406863008374 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1406863008375 Replication protein; Region: Rep_1; pfam01446 1406863008376 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1406863008377 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1406863008378 Replication protein; Region: Rep_1; cl02412 1406863008379 Cadmium resistance transporter; Region: Cad; pfam03596 1406863008380 Cadmium resistance transporter; Region: Cad; pfam03596 1406863008381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1406863008382 putative DNA binding site [nucleotide binding]; other site 1406863008383 putative Zn2+ binding site [ion binding]; other site 1406863008384 Replication protein; Region: Rep_1; cl02412 1406863008385 Replication protein; Region: Rep_1; pfam01446 1406863008386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1406863008387 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1406863008388 Integrase core domain; Region: rve; pfam00665 1406863008389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1406863008390 Integrase core domain; Region: rve; pfam00665 1406863008391 alkylmercury lyase; Provisional; Region: PRK13239 1406863008392 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 1406863008393 Alkylmercury lyase; Region: MerB; pfam03243 1406863008394 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1406863008395 metal-binding site [ion binding] 1406863008396 mercuric reductase; Region: MerA; TIGR02053 1406863008397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1406863008398 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1406863008399 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1406863008400 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1406863008401 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1406863008402 catalytic residues [active] 1406863008403 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 1406863008404 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1406863008405 DNA binding residues [nucleotide binding] 1406863008406 dimer interface [polypeptide binding]; other site 1406863008407 mercury binding site [ion binding]; other site 1406863008408 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1406863008409 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1406863008410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1406863008411 Integrase core domain; Region: rve; pfam00665 1406863008412 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1406863008413 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1406863008414 metal-binding site [ion binding] 1406863008415 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1406863008416 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1406863008417 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1406863008418 dimerization interface [polypeptide binding]; other site 1406863008419 putative DNA binding site [nucleotide binding]; other site 1406863008420 putative Zn2+ binding site [ion binding]; other site 1406863008421 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1406863008422 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1406863008423 catalytic residues [active] 1406863008424 catalytic nucleophile [active] 1406863008425 Presynaptic Site I dimer interface [polypeptide binding]; other site 1406863008426 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1406863008427 Synaptic Flat tetramer interface [polypeptide binding]; other site 1406863008428 Synaptic Site I dimer interface [polypeptide binding]; other site 1406863008429 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1406863008430 DNA-binding interface [nucleotide binding]; DNA binding site 1406863008431 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1406863008432 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1406863008433 catalytic residues [active] 1406863008434 catalytic nucleophile [active] 1406863008435 Presynaptic Site I dimer interface [polypeptide binding]; other site 1406863008436 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1406863008437 Synaptic Flat tetramer interface [polypeptide binding]; other site 1406863008438 Synaptic Site I dimer interface [polypeptide binding]; other site 1406863008439 DNA binding site [nucleotide binding] 1406863008440 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1406863008441 DNA-binding interface [nucleotide binding]; DNA binding site 1406863008442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1406863008443 non-specific DNA binding site [nucleotide binding]; other site 1406863008444 salt bridge; other site 1406863008445 sequence-specific DNA binding site [nucleotide binding]; other site 1406863008446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1406863008447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1406863008448 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1406863008449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1406863008450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1406863008451 putative substrate translocation pore; other site