-- dump date 20140620_075441
-- class Genbank::misc_feature
-- table misc_feature_note
-- id note
1074919000001 DDE domain; Region: DDE_Tnp_IS240; pfam13610
1074919000002 Integrase core domain; Region: rve; pfam00665
1074919000003 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1074919000004 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1074919000005 metal-binding site [ion binding]
1074919000006 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1074919000007 Soluble P-type ATPase [General function prediction only]; Region: COG4087
1074919000008 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1074919000009 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
1074919000010 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1074919000011 Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1074919000012 multiple promoter invertase; Provisional; Region: mpi; PRK13413
1074919000013 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1074919000014 catalytic residues [active]
1074919000015 catalytic nucleophile [active]
1074919000016 Presynaptic Site I dimer interface [polypeptide binding]; other site
1074919000017 Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1074919000018 Synaptic Flat tetramer interface [polypeptide binding]; other site
1074919000019 Synaptic Site I dimer interface [polypeptide binding]; other site
1074919000020 DNA binding site [nucleotide binding]
1074919000021 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
1074919000022 DNA-binding interface [nucleotide binding]; DNA binding site
1074919000023 multiple promoter invertase; Provisional; Region: mpi; PRK13413
1074919000024 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1074919000025 catalytic residues [active]
1074919000026 catalytic nucleophile [active]
1074919000027 Presynaptic Site I dimer interface [polypeptide binding]; other site
1074919000028 Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1074919000029 Synaptic Flat tetramer interface [polypeptide binding]; other site
1074919000030 Synaptic Site I dimer interface [polypeptide binding]; other site
1074919000031 DNA binding site [nucleotide binding]
1074919000032 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
1074919000033 DNA-binding interface [nucleotide binding]; DNA binding site
1074919000034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919000035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919000036 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1074919000037 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1074919000038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000039 putative substrate translocation pore; other site
1074919000040 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
1074919000041 Replication protein; Region: Rep_1; pfam01446
1074919000042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1074919000043 Integrase core domain; Region: rve; pfam00665
1074919000044 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1074919000045 DnaA N-terminal domain; Region: DnaA_N; pfam11638
1074919000046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919000047 Walker A motif; other site
1074919000048 ATP binding site [chemical binding]; other site
1074919000049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1074919000050 Walker B motif; other site
1074919000051 arginine finger; other site
1074919000052 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1074919000053 DnaA box-binding interface [nucleotide binding]; other site
1074919000054 DNA polymerase III subunit beta; Validated; Region: PRK05643
1074919000055 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1074919000056 putative DNA binding surface [nucleotide binding]; other site
1074919000057 dimer interface [polypeptide binding]; other site
1074919000058 beta-clamp/clamp loader binding surface; other site
1074919000059 beta-clamp/translesion DNA polymerase binding surface; other site
1074919000060 recF protein; Region: recf; TIGR00611
1074919000061 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1074919000062 Walker A/P-loop; other site
1074919000063 ATP binding site [chemical binding]; other site
1074919000064 Q-loop/lid; other site
1074919000065 ABC transporter signature motif; other site
1074919000066 Walker B; other site
1074919000067 D-loop; other site
1074919000068 H-loop/switch region; other site
1074919000069 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1074919000070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919000071 ATP binding site [chemical binding]; other site
1074919000072 Mg2+ binding site [ion binding]; other site
1074919000073 G-X-G motif; other site
1074919000074 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1074919000075 anchoring element; other site
1074919000076 dimer interface [polypeptide binding]; other site
1074919000077 ATP binding site [chemical binding]; other site
1074919000078 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1074919000079 active site
1074919000080 putative metal-binding site [ion binding]; other site
1074919000081 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1074919000082 DNA gyrase subunit A; Validated; Region: PRK05560
1074919000083 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1074919000084 CAP-like domain; other site
1074919000085 active site
1074919000086 primary dimer interface [polypeptide binding]; other site
1074919000087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000091 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919000093 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1074919000094 putative substrate binding site [chemical binding]; other site
1074919000095 putative ATP binding site [chemical binding]; other site
1074919000096 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1074919000097 active sites [active]
1074919000098 tetramer interface [polypeptide binding]; other site
1074919000099 seryl-tRNA synthetase; Provisional; Region: PRK05431
1074919000100 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1074919000101 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1074919000102 dimer interface [polypeptide binding]; other site
1074919000103 active site
1074919000104 motif 1; other site
1074919000105 motif 2; other site
1074919000106 motif 3; other site
1074919000107 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1074919000108 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1074919000109 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1074919000110 Predicted membrane protein [Function unknown]; Region: COG4241
1074919000111 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1074919000112 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1074919000113 DHH family; Region: DHH; pfam01368
1074919000114 DHHA1 domain; Region: DHHA1; pfam02272
1074919000115 replicative DNA helicase; Region: DnaB; TIGR00665
1074919000116 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1074919000117 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1074919000118 Walker A motif; other site
1074919000119 ATP binding site [chemical binding]; other site
1074919000120 Walker B motif; other site
1074919000121 DNA binding loops [nucleotide binding]
1074919000122 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1074919000123 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1074919000124 GDP-binding site [chemical binding]; other site
1074919000125 ACT binding site; other site
1074919000126 IMP binding site; other site
1074919000127 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919000128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919000129 active site
1074919000130 phosphorylation site [posttranslational modification]
1074919000131 intermolecular recognition site; other site
1074919000132 dimerization interface [polypeptide binding]; other site
1074919000133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919000134 DNA binding site [nucleotide binding]
1074919000135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1074919000136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074919000137 dimerization interface [polypeptide binding]; other site
1074919000138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1074919000139 putative active site [active]
1074919000140 heme pocket [chemical binding]; other site
1074919000141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919000142 dimer interface [polypeptide binding]; other site
1074919000143 phosphorylation site [posttranslational modification]
1074919000144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919000145 ATP binding site [chemical binding]; other site
1074919000146 Mg2+ binding site [ion binding]; other site
1074919000147 G-X-G motif; other site
1074919000148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1074919000149 YycH protein; Region: YycH; pfam07435
1074919000150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
1074919000151 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1074919000152 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1074919000153 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
1074919000154 putative active site [active]
1074919000155 putative metal binding site [ion binding]; other site
1074919000156 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1074919000157 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1074919000158 rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1074919000159 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
1074919000160 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
1074919000161 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919000162 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1074919000163 putative active site [active]
1074919000164 catalytic site [active]
1074919000165 putative metal binding site [ion binding]; other site
1074919000166 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1074919000167 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1074919000168 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1074919000169 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1074919000170 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1074919000171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1074919000172 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1074919000173 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1074919000174 Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1074919000175 Recombinase; Region: Recombinase; pfam07508
1074919000176 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1074919000177 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1074919000178 catalytic residues [active]
1074919000179 catalytic nucleophile [active]
1074919000180 Recombinase; Region: Recombinase; pfam07508
1074919000181 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1074919000182 Domain of unknown function (DUF927); Region: DUF927; pfam06048
1074919000183 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1074919000184 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1074919000185 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074919000186 active site residue [active]
1074919000187 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074919000188 active site residue [active]
1074919000189 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
1074919000190 CPxP motif; other site
1074919000191 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1074919000192 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1074919000193 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1074919000194 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949
1074919000195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919000196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919000197 sporadically distributed protein, TIGR04141 family; Region: TIGR04141
1074919000198 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1074919000199 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074919000200 active site residue [active]
1074919000201 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
1074919000202 CPxP motif; other site
1074919000203 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1074919000204 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1074919000205 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1074919000206 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1074919000207 active site residue [active]
1074919000208 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1074919000209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1074919000210 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1074919000211 Dihydrouridine synthase (Dus); Region: Dus; pfam01207
1074919000212 FMN binding site [chemical binding]; other site
1074919000213 active site
1074919000214 catalytic residues [active]
1074919000215 substrate binding site [chemical binding]; other site
1074919000216 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1074919000217 Part of AAA domain; Region: AAA_19; pfam13245
1074919000218 AAA domain; Region: AAA_12; pfam13087
1074919000219 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1074919000220 active site
1074919000221 catalytic site [active]
1074919000222 putative metal binding site [ion binding]; other site
1074919000223 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919000224 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919000225 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919000226 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919000227 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919000228 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1074919000229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919000230 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1074919000231 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074919000232 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1074919000233 metal binding site [ion binding]; metal-binding site
1074919000234 dimer interface [polypeptide binding]; other site
1074919000235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000236 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919000237 putative substrate translocation pore; other site
1074919000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000239 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1074919000240 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1074919000241 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1074919000242 PhoU domain; Region: PhoU; pfam01895
1074919000243 Myosin-crossreactive antigen [Function unknown]; Region: COG4716
1074919000244 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1074919000245 EamA-like transporter family; Region: EamA; pfam00892
1074919000246 EamA-like transporter family; Region: EamA; pfam00892
1074919000247 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1074919000248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919000249 DNA-binding site [nucleotide binding]; DNA binding site
1074919000250 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919000251 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919000252 homodimer interface [polypeptide binding]; other site
1074919000253 catalytic residue [active]
1074919000254 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1074919000255 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1074919000256 L-lactate permease; Region: Lactate_perm; cl00701
1074919000257 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919000258 B domain; Region: B; pfam02216
1074919000259 B domain; Region: B; pfam02216
1074919000260 B domain; Region: B; pfam02216
1074919000261 B domain; Region: B; pfam02216
1074919000262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919000263 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919000264 Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919000265 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919000266 Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919000267 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074919000268 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919000269 ABC-ATPase subunit interface; other site
1074919000270 dimer interface [polypeptide binding]; other site
1074919000271 putative PBP binding regions; other site
1074919000272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919000273 ABC-ATPase subunit interface; other site
1074919000274 dimer interface [polypeptide binding]; other site
1074919000275 putative PBP binding regions; other site
1074919000276 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1074919000277 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1074919000278 siderophore binding site; other site
1074919000279 cysteine synthase; Region: PLN02565
1074919000280 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1074919000281 dimer interface [polypeptide binding]; other site
1074919000282 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919000283 catalytic residue [active]
1074919000284 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
1074919000285 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124
1074919000286 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919000287 IucA / IucC family; Region: IucA_IucC; pfam04183
1074919000288 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919000289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000290 putative substrate translocation pore; other site
1074919000291 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919000292 IucA / IucC family; Region: IucA_IucC; pfam04183
1074919000293 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919000294 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919000295 IucA / IucC family; Region: IucA_IucC; pfam04183
1074919000296 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919000297 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1074919000298 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1074919000299 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
1074919000300 dimer interface [polypeptide binding]; other site
1074919000301 active site
1074919000302 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919000303 catalytic residues [active]
1074919000304 substrate binding site [chemical binding]; other site
1074919000305 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1074919000306 ParB-like nuclease domain; Region: ParBc; pfam02195
1074919000307 acetoin reductase; Validated; Region: PRK08643
1074919000308 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1074919000309 NAD binding site [chemical binding]; other site
1074919000310 homotetramer interface [polypeptide binding]; other site
1074919000311 homodimer interface [polypeptide binding]; other site
1074919000312 active site
1074919000313 substrate binding site [chemical binding]; other site
1074919000314 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1074919000315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919000316 NAD(P) binding site [chemical binding]; other site
1074919000317 active site
1074919000318 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1074919000319 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1074919000320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919000321 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1074919000322 putative ADP-binding pocket [chemical binding]; other site
1074919000323 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1074919000324 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1074919000325 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1074919000326 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1074919000327 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1074919000328 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1074919000329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919000330 DNA-binding site [nucleotide binding]; DNA binding site
1074919000331 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1074919000332 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1074919000333 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919000334 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1074919000335 intersubunit interface [polypeptide binding]; other site
1074919000336 active site
1074919000337 catalytic residue [active]
1074919000338 phosphopentomutase; Region: deoB; TIGR01696
1074919000339 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1074919000340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000341 dimer interface [polypeptide binding]; other site
1074919000342 conserved gate region; other site
1074919000343 ABC-ATPase subunit interface; other site
1074919000344 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1074919000345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000346 dimer interface [polypeptide binding]; other site
1074919000347 conserved gate region; other site
1074919000348 putative PBP binding loops; other site
1074919000349 ABC-ATPase subunit interface; other site
1074919000350 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1074919000351 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1074919000352 Walker A/P-loop; other site
1074919000353 ATP binding site [chemical binding]; other site
1074919000354 Q-loop/lid; other site
1074919000355 ABC transporter signature motif; other site
1074919000356 Walker B; other site
1074919000357 D-loop; other site
1074919000358 H-loop/switch region; other site
1074919000359 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1074919000360 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1074919000361 substrate binding pocket [chemical binding]; other site
1074919000362 membrane-bound complex binding site; other site
1074919000363 hinge residues; other site
1074919000364 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1074919000365 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1074919000366 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1074919000367 active site
1074919000368 metal binding site [ion binding]; metal-binding site
1074919000369 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1074919000370 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074919000371 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919000372 non-specific DNA binding site [nucleotide binding]; other site
1074919000373 salt bridge; other site
1074919000374 sequence-specific DNA binding site [nucleotide binding]; other site
1074919000375 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1074919000376 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1074919000377 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1074919000378 putative catalytic cysteine [active]
1074919000379 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1074919000380 putative active site [active]
1074919000381 metal binding site [ion binding]; metal-binding site
1074919000382 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
1074919000383 Chain length determinant protein; Region: Wzz; pfam02706
1074919000384 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1074919000385 capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1074919000386 AAA domain; Region: AAA_31; pfam13614
1074919000387 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1074919000388 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1074919000389 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1074919000390 NAD(P) binding site [chemical binding]; other site
1074919000391 homodimer interface [polypeptide binding]; other site
1074919000392 substrate binding site [chemical binding]; other site
1074919000393 active site
1074919000394 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
1074919000395 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1074919000396 NAD(P) binding site [chemical binding]; other site
1074919000397 homodimer interface [polypeptide binding]; other site
1074919000398 substrate binding site [chemical binding]; other site
1074919000399 active site
1074919000400 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
1074919000401 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
1074919000402 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1074919000403 putative NAD(P) binding site [chemical binding]; other site
1074919000404 active site
1074919000405 putative substrate binding site [chemical binding]; other site
1074919000406 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1074919000407 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1074919000408 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1074919000409 active site
1074919000410 homodimer interface [polypeptide binding]; other site
1074919000411 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1074919000412 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1074919000413 trimer interface [polypeptide binding]; other site
1074919000414 active site
1074919000415 substrate binding site [chemical binding]; other site
1074919000416 CoA binding site [chemical binding]; other site
1074919000417 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919000418 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1074919000419 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1074919000420 O-Antigen ligase; Region: Wzy_C; pfam04932
1074919000421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919000422 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1074919000423 Bacterial sugar transferase; Region: Bac_transf; pfam02397
1074919000424 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
1074919000425 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1074919000426 putative NAD(P) binding site [chemical binding]; other site
1074919000427 active site
1074919000428 putative substrate binding site [chemical binding]; other site
1074919000429 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1074919000430 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
1074919000431 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1074919000432 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1074919000433 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1074919000434 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1074919000435 active site
1074919000436 homodimer interface [polypeptide binding]; other site
1074919000437 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
1074919000438 NAD(P) binding site [chemical binding]; other site
1074919000439 catalytic residues [active]
1074919000440 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1074919000441 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1074919000442 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
1074919000443 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1074919000444 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1074919000445 Walker A/P-loop; other site
1074919000446 ATP binding site [chemical binding]; other site
1074919000447 Q-loop/lid; other site
1074919000448 ABC transporter signature motif; other site
1074919000449 Walker B; other site
1074919000450 D-loop; other site
1074919000451 H-loop/switch region; other site
1074919000452 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1074919000453 NMT1-like family; Region: NMT1_2; cl17432
1074919000454 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1074919000455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1074919000456 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1074919000457 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1074919000458 active site
1074919000459 formate dehydrogenase; Provisional; Region: PRK07574
1074919000460 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
1074919000461 dimerization interface [polypeptide binding]; other site
1074919000462 ligand binding site [chemical binding]; other site
1074919000463 NAD binding site [chemical binding]; other site
1074919000464 catalytic site [active]
1074919000465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000466 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919000467 putative substrate translocation pore; other site
1074919000468 Condensation domain; Region: Condensation; cl19241
1074919000469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074919000470 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1074919000471 acyl-activating enzyme (AAE) consensus motif; other site
1074919000472 AMP binding site [chemical binding]; other site
1074919000473 active site
1074919000474 CoA binding site [chemical binding]; other site
1074919000475 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1074919000476 Condensation domain; Region: Condensation; pfam00668
1074919000477 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1074919000478 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1074919000479 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1074919000480 acyl-activating enzyme (AAE) consensus motif; other site
1074919000481 AMP binding site [chemical binding]; other site
1074919000482 Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1074919000483 thioester reductase domain; Region: Thioester-redct; TIGR01746
1074919000484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919000485 NAD(P) binding site [chemical binding]; other site
1074919000486 active site
1074919000487 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1074919000488 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1074919000489 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
1074919000490 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1074919000491 nucleotide binding site [chemical binding]; other site
1074919000492 N-acetyl-L-glutamate binding site [chemical binding]; other site
1074919000493 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1074919000494 heterotetramer interface [polypeptide binding]; other site
1074919000495 active site pocket [active]
1074919000496 cleavage site
1074919000497 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1074919000498 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
1074919000499 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
1074919000500 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1074919000501 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919000502 inhibitor-cofactor binding pocket; inhibition site
1074919000503 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919000504 catalytic residue [active]
1074919000505 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1074919000506 Isochorismatase family; Region: Isochorismatase; pfam00857
1074919000507 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1074919000508 catalytic triad [active]
1074919000509 conserved cis-peptide bond; other site
1074919000510 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1074919000511 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1074919000512 dimer interface [polypeptide binding]; other site
1074919000513 PYR/PP interface [polypeptide binding]; other site
1074919000514 TPP binding site [chemical binding]; other site
1074919000515 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074919000516 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1074919000517 TPP-binding site [chemical binding]; other site
1074919000518 dimer interface [polypeptide binding]; other site
1074919000519 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919000520 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1074919000521 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919000522 active site turn [active]
1074919000523 phosphorylation site [posttranslational modification]
1074919000524 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1074919000525 HPr interaction site; other site
1074919000526 glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074919000527 active site
1074919000528 phosphorylation site [posttranslational modification]
1074919000529 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1074919000530 Uncharacterized conserved protein [Function unknown]; Region: COG3589
1074919000531 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
1074919000532 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1074919000533 putative active site [active]
1074919000534 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1074919000535 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919000536 active site turn [active]
1074919000537 phosphorylation site [posttranslational modification]
1074919000538 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919000539 Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919000540 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1074919000541 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1074919000542 putative active site [active]
1074919000543 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1074919000544 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1074919000545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919000546 ATP binding site [chemical binding]; other site
1074919000547 putative Mg++ binding site [ion binding]; other site
1074919000548 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1074919000549 HlyD family secretion protein; Region: HlyD_3; pfam13437
1074919000550 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919000551 Walker A/P-loop; other site
1074919000552 ATP binding site [chemical binding]; other site
1074919000553 ABC transporter; Region: ABC_tran; pfam00005
1074919000554 Q-loop/lid; other site
1074919000555 ABC transporter signature motif; other site
1074919000556 Walker B; other site
1074919000557 D-loop; other site
1074919000558 H-loop/switch region; other site
1074919000559 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074919000560 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1074919000561 FtsX-like permease family; Region: FtsX; pfam02687
1074919000562 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
1074919000563 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919000564 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919000565 Walker A/P-loop; other site
1074919000566 ATP binding site [chemical binding]; other site
1074919000567 Q-loop/lid; other site
1074919000568 ABC transporter signature motif; other site
1074919000569 Walker B; other site
1074919000570 D-loop; other site
1074919000571 H-loop/switch region; other site
1074919000572 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1074919000573 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919000574 Walker A/P-loop; other site
1074919000575 ATP binding site [chemical binding]; other site
1074919000576 Q-loop/lid; other site
1074919000577 ABC transporter signature motif; other site
1074919000578 Walker B; other site
1074919000579 D-loop; other site
1074919000580 H-loop/switch region; other site
1074919000581 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1074919000582 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919000583 Walker A/P-loop; other site
1074919000584 ATP binding site [chemical binding]; other site
1074919000585 Q-loop/lid; other site
1074919000586 ABC transporter signature motif; other site
1074919000587 Walker B; other site
1074919000588 D-loop; other site
1074919000589 H-loop/switch region; other site
1074919000590 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919000591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000592 dimer interface [polypeptide binding]; other site
1074919000593 conserved gate region; other site
1074919000594 putative PBP binding loops; other site
1074919000595 ABC-ATPase subunit interface; other site
1074919000596 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1074919000597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000598 dimer interface [polypeptide binding]; other site
1074919000599 conserved gate region; other site
1074919000600 putative PBP binding loops; other site
1074919000601 ABC-ATPase subunit interface; other site
1074919000602 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1074919000603 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1074919000604 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074919000605 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1074919000606 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742
1074919000607 azoreductase; Reviewed; Region: PRK00170
1074919000608 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074919000609 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074919000610 Peptidase family M23; Region: Peptidase_M23; pfam01551
1074919000611 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1074919000612 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1074919000613 Walker A/P-loop; other site
1074919000614 ATP binding site [chemical binding]; other site
1074919000615 Q-loop/lid; other site
1074919000616 ABC transporter signature motif; other site
1074919000617 Walker B; other site
1074919000618 D-loop; other site
1074919000619 H-loop/switch region; other site
1074919000620 TOBE domain; Region: TOBE; pfam03459
1074919000621 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1074919000622 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1074919000623 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1074919000624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000625 dimer interface [polypeptide binding]; other site
1074919000626 conserved gate region; other site
1074919000627 putative PBP binding loops; other site
1074919000628 ABC-ATPase subunit interface; other site
1074919000629 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1074919000630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919000631 dimer interface [polypeptide binding]; other site
1074919000632 conserved gate region; other site
1074919000633 putative PBP binding loops; other site
1074919000634 ABC-ATPase subunit interface; other site
1074919000635 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1074919000636 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1074919000637 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1074919000638 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1074919000639 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1074919000640 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1074919000641 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1074919000642 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1074919000643 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1074919000644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1074919000645 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1074919000646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000647 putative substrate translocation pore; other site
1074919000648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919000649 intermolecular recognition site; other site
1074919000650 active site
1074919000651 dimerization interface [polypeptide binding]; other site
1074919000652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919000653 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1074919000654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919000655 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1074919000656 Histidine kinase; Region: His_kinase; pfam06580
1074919000657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919000658 ATP binding site [chemical binding]; other site
1074919000659 Mg2+ binding site [ion binding]; other site
1074919000660 G-X-G motif; other site
1074919000661 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1074919000662 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1074919000663 Pyruvate formate lyase 1; Region: PFL1; cd01678
1074919000664 coenzyme A binding site [chemical binding]; other site
1074919000665 active site
1074919000666 catalytic residues [active]
1074919000667 glycine loop; other site
1074919000668 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1074919000669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919000670 FeS/SAM binding site; other site
1074919000671 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1074919000672 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
1074919000673 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919000674 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1074919000675 putative active site [active]
1074919000676 catalytic site [active]
1074919000677 putative metal binding site [ion binding]; other site
1074919000678 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1074919000679 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000680 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000681 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000682 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000683 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000684 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
1074919000685 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1074919000686 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1074919000687 dimer interface [polypeptide binding]; other site
1074919000688 active site
1074919000689 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1074919000690 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1074919000691 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1074919000692 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1074919000693 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1074919000694 substrate binding site [chemical binding]; other site
1074919000695 oxyanion hole (OAH) forming residues; other site
1074919000696 trimer interface [polypeptide binding]; other site
1074919000697 Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1074919000698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1074919000699 active site
1074919000700 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1074919000701 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074919000702 acyl-activating enzyme (AAE) consensus motif; other site
1074919000703 AMP binding site [chemical binding]; other site
1074919000704 active site
1074919000705 CoA binding site [chemical binding]; other site
1074919000706 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1074919000707 Coenzyme A transferase; Region: CoA_trans; smart00882
1074919000708 Coenzyme A transferase; Region: CoA_trans; cl17247
1074919000709 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1074919000710 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074919000711 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1074919000712 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1074919000713 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1074919000714 heme-binding site [chemical binding]; other site
1074919000715 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1074919000716 FAD binding pocket [chemical binding]; other site
1074919000717 FAD binding motif [chemical binding]; other site
1074919000718 phosphate binding motif [ion binding]; other site
1074919000719 beta-alpha-beta structure motif; other site
1074919000720 NAD binding pocket [chemical binding]; other site
1074919000721 Heme binding pocket [chemical binding]; other site
1074919000722 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1074919000723 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1074919000724 tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074919000725 NAD binding site [chemical binding]; other site
1074919000726 dimer interface [polypeptide binding]; other site
1074919000727 substrate binding site [chemical binding]; other site
1074919000728 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1074919000729 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919000730 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919000731 active site turn [active]
1074919000732 phosphorylation site [posttranslational modification]
1074919000733 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1074919000734 active site
1074919000735 tetramer interface [polypeptide binding]; other site
1074919000736 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919000737 Mga helix-turn-helix domain; Region: Mga; pfam05043
1074919000738 PRD domain; Region: PRD; pfam00874
1074919000739 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1074919000740 active site
1074919000741 P-loop; other site
1074919000742 phosphorylation site [posttranslational modification]
1074919000743 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919000744 active site
1074919000745 phosphorylation site [posttranslational modification]
1074919000746 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919000747 active site
1074919000748 phosphorylation site [posttranslational modification]
1074919000749 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1074919000750 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1074919000751 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1074919000752 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
1074919000753 putative NAD(P) binding site [chemical binding]; other site
1074919000754 catalytic Zn binding site [ion binding]; other site
1074919000755 structural Zn binding site [ion binding]; other site
1074919000756 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1074919000757 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
1074919000758 putative NAD(P) binding site [chemical binding]; other site
1074919000759 catalytic Zn binding site [ion binding]; other site
1074919000760 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1074919000761 substrate binding site; other site
1074919000762 dimer interface; other site
1074919000763 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1074919000764 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1074919000765 NAD(P) binding site [chemical binding]; other site
1074919000766 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919000767 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1074919000768 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919000769 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1074919000770 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1074919000771 substrate binding site; other site
1074919000772 dimer interface; other site
1074919000773 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1074919000774 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1074919000775 NAD(P) binding site [chemical binding]; other site
1074919000776 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919000777 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1074919000778 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1074919000779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1074919000780 active site
1074919000781 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
1074919000782 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1074919000783 Hemerythrin-like domain; Region: Hr-like; cd12108
1074919000784 Fe binding site [ion binding]; other site
1074919000785 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1074919000786 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1074919000787 Histidine kinase; Region: His_kinase; pfam06580
1074919000788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919000789 Mg2+ binding site [ion binding]; other site
1074919000790 G-X-G motif; other site
1074919000791 two-component response regulator; Provisional; Region: PRK14084
1074919000792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919000793 active site
1074919000794 phosphorylation site [posttranslational modification]
1074919000795 intermolecular recognition site; other site
1074919000796 dimerization interface [polypeptide binding]; other site
1074919000797 LytTr DNA-binding domain; Region: LytTR; pfam04397
1074919000798 antiholin-like protein LrgB; Provisional; Region: PRK04288
1074919000799 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1074919000800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919000801 DNA-binding site [nucleotide binding]; DNA binding site
1074919000802 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1074919000803 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1074919000804 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1074919000805 HPr interaction site; other site
1074919000806 glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074919000807 active site
1074919000808 phosphorylation site [posttranslational modification]
1074919000809 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1074919000810 beta-galactosidase; Region: BGL; TIGR03356
1074919000811 Methyltransferase domain; Region: Methyltransf_31; pfam13847
1074919000812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919000813 S-adenosylmethionine binding site [chemical binding]; other site
1074919000814 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1074919000815 substrate binding site [chemical binding]; other site
1074919000816 dimer interface [polypeptide binding]; other site
1074919000817 ATP binding site [chemical binding]; other site
1074919000818 D-ribose pyranase; Provisional; Region: PRK11797
1074919000819 Sugar transport protein; Region: Sugar_transport; pfam06800
1074919000820 Transcriptional regulators [Transcription]; Region: PurR; COG1609
1074919000821 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1074919000822 DNA binding site [nucleotide binding]
1074919000823 domain linker motif; other site
1074919000824 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1074919000825 dimerization interface [polypeptide binding]; other site
1074919000826 ligand binding site [chemical binding]; other site
1074919000827 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919000828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000829 putative substrate translocation pore; other site
1074919000830 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1074919000831 active site
1074919000832 Surface antigen [General function prediction only]; Region: COG3942
1074919000833 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074919000834 Peptidase family M23; Region: Peptidase_M23; pfam01551
1074919000835 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919000836 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1074919000837 Walker A/P-loop; other site
1074919000838 ATP binding site [chemical binding]; other site
1074919000839 Q-loop/lid; other site
1074919000840 ABC transporter signature motif; other site
1074919000841 Walker B; other site
1074919000842 D-loop; other site
1074919000843 H-loop/switch region; other site
1074919000844 Surface antigen [General function prediction only]; Region: COG3942
1074919000845 CHAP domain; Region: CHAP; pfam05257
1074919000846 Predicted membrane protein [Function unknown]; Region: COG1511
1074919000847 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1074919000848 ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1074919000849 Predicted membrane protein [Function unknown]; Region: COG4499
1074919000850 TolA protein; Region: tolA_full; TIGR02794
1074919000851 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1074919000852 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1074919000853 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074919000854 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074919000855 Uncharacterized conserved protein [Function unknown]; Region: COG5444
1074919000856 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1074919000857 Protein of unknown function, DUF600; Region: DUF600; cl04640
1074919000858 Protein of unknown function, DUF600; Region: DUF600; cl04640
1074919000859 Protein of unknown function, DUF600; Region: DUF600; cl04640
1074919000860 Protein of unknown function, DUF600; Region: DUF600; cl04640
1074919000861 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1074919000862 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1074919000863 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
1074919000864 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1074919000865 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074919000866 FtsX-like permease family; Region: FtsX; pfam02687
1074919000867 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919000868 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919000869 Walker A/P-loop; other site
1074919000870 ATP binding site [chemical binding]; other site
1074919000871 Q-loop/lid; other site
1074919000872 ABC transporter signature motif; other site
1074919000873 Walker B; other site
1074919000874 D-loop; other site
1074919000875 H-loop/switch region; other site
1074919000876 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1074919000877 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1074919000878 putative kinase; Provisional; Region: PRK09954
1074919000879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919000880 non-specific DNA binding site [nucleotide binding]; other site
1074919000881 salt bridge; other site
1074919000882 sequence-specific DNA binding site [nucleotide binding]; other site
1074919000883 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1074919000884 substrate binding site [chemical binding]; other site
1074919000885 ATP binding site [chemical binding]; other site
1074919000886 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
1074919000887 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1074919000888 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1074919000889 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1074919000890 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
1074919000891 putative transporter; Provisional; Region: PRK10484
1074919000892 Na binding site [ion binding]; other site
1074919000893 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1074919000894 inhibitor site; inhibition site
1074919000895 active site
1074919000896 dimer interface [polypeptide binding]; other site
1074919000897 catalytic residue [active]
1074919000898 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1074919000899 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1074919000900 nucleotide binding site [chemical binding]; other site
1074919000901 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1074919000902 Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919000903 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1074919000904 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1074919000905 putative active site [active]
1074919000906 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1074919000907 putative active site cavity [active]
1074919000908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1074919000909 Nucleoside recognition; Region: Gate; pfam07670
1074919000910 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1074919000911 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1074919000912 PGAP1-like protein; Region: PGAP1; pfam07819
1074919000913 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1074919000914 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094
1074919000915 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1074919000916 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1074919000917 putative active site [active]
1074919000918 putative FMN binding site [chemical binding]; other site
1074919000919 putative substrate binding site [chemical binding]; other site
1074919000920 putative catalytic residue [active]
1074919000921 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1074919000922 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1074919000923 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1074919000924 Replication protein C N-terminal domain; Region: RP-C; pfam03428
1074919000925 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
1074919000926 putative ADP-ribose binding site [chemical binding]; other site
1074919000927 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
1074919000928 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1074919000929 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1074919000930 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1074919000931 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1074919000932 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
1074919000933 NADP binding site [chemical binding]; other site
1074919000934 putative substrate binding site [chemical binding]; other site
1074919000935 active site
1074919000936 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1074919000937 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919000938 HTH domain; Region: HTH_11; pfam08279
1074919000939 HTH domain; Region: HTH_11; pfam08279
1074919000940 PRD domain; Region: PRD; pfam00874
1074919000941 PRD domain; Region: PRD; pfam00874
1074919000942 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1074919000943 active site
1074919000944 P-loop; other site
1074919000945 phosphorylation site [posttranslational modification]
1074919000946 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919000947 active site
1074919000948 phosphorylation site [posttranslational modification]
1074919000949 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1074919000950 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1074919000951 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1074919000952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000953 putative substrate translocation pore; other site
1074919000954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919000955 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1074919000956 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1074919000957 Zn binding site [ion binding]; other site
1074919000958 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1074919000959 Zn binding site [ion binding]; other site
1074919000960 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
1074919000961 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1074919000962 Predicted flavoprotein [General function prediction only]; Region: COG0431
1074919000963 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074919000964 Predicted membrane protein [Function unknown]; Region: COG2855
1074919000965 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1074919000966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919000967 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
1074919000968 Imelysin; Region: Peptidase_M75; pfam09375
1074919000969 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1074919000970 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1074919000971 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1074919000972 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1074919000973 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
1074919000974 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074919000975 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919000976 Walker A/P-loop; other site
1074919000977 ATP binding site [chemical binding]; other site
1074919000978 Q-loop/lid; other site
1074919000979 ABC transporter signature motif; other site
1074919000980 Walker B; other site
1074919000981 D-loop; other site
1074919000982 H-loop/switch region; other site
1074919000983 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1074919000984 Predicted membrane protein [Function unknown]; Region: COG4292
1074919000985 putative acyltransferase; Provisional; Region: PRK05790
1074919000986 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1074919000987 dimer interface [polypeptide binding]; other site
1074919000988 active site
1074919000989 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1074919000990 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1074919000991 methionine synthase; Provisional; Region: PRK01207
1074919000992 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1074919000993 substrate binding site [chemical binding]; other site
1074919000994 THF binding site; other site
1074919000995 zinc-binding site [ion binding]; other site
1074919000996 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1074919000997 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1074919000998 FAD binding site [chemical binding]; other site
1074919000999 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1074919001000 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1074919001001 homodimer interface [polypeptide binding]; other site
1074919001002 substrate-cofactor binding pocket; other site
1074919001003 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001004 catalytic residue [active]
1074919001005 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
1074919001006 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919001007 catalytic residue [active]
1074919001008 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1074919001009 ParB-like nuclease domain; Region: ParB; smart00470
1074919001010 KorB domain; Region: KorB; pfam08535
1074919001011 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1074919001012 Mechanosensitive ion channel; Region: MS_channel; pfam00924
1074919001013 GTP-binding protein YchF; Reviewed; Region: PRK09601
1074919001014 YchF GTPase; Region: YchF; cd01900
1074919001015 G1 box; other site
1074919001016 GTP/Mg2+ binding site [chemical binding]; other site
1074919001017 Switch I region; other site
1074919001018 G2 box; other site
1074919001019 Switch II region; other site
1074919001020 G3 box; other site
1074919001021 G4 box; other site
1074919001022 G5 box; other site
1074919001023 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1074919001024 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1074919001025 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1074919001026 dimer interface [polypeptide binding]; other site
1074919001027 ssDNA binding site [nucleotide binding]; other site
1074919001028 tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074919001029 Abi-like protein; Region: Abi_2; pfam07751
1074919001030 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001031 Predicted membrane protein [Function unknown]; Region: COG3212
1074919001032 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1074919001033 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074919001034 catalytic core [active]
1074919001035 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
1074919001036 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1074919001037 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1074919001038 catalytic residue [active]
1074919001039 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1074919001040 catalytic residues [active]
1074919001041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1074919001042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919001043 peroxiredoxin; Region: AhpC; TIGR03137
1074919001044 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1074919001045 dimer interface [polypeptide binding]; other site
1074919001046 decamer (pentamer of dimers) interface [polypeptide binding]; other site
1074919001047 catalytic triad [active]
1074919001048 peroxidatic and resolving cysteines [active]
1074919001049 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1074919001050 dimer interface [polypeptide binding]; other site
1074919001051 FMN binding site [chemical binding]; other site
1074919001052 NADPH bind site [chemical binding]; other site
1074919001053 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1074919001054 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1074919001055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919001056 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
1074919001057 Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919001058 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
1074919001059 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919001060 active site
1074919001061 Sulfate transporter family; Region: Sulfate_transp; cl19250
1074919001062 xanthine permease; Region: pbuX; TIGR03173
1074919001063 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1074919001064 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1074919001065 active site
1074919001066 GMP synthase; Reviewed; Region: guaA; PRK00074
1074919001067 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1074919001068 AMP/PPi binding site [chemical binding]; other site
1074919001069 candidate oxyanion hole; other site
1074919001070 catalytic triad [active]
1074919001071 potential glutamine specificity residues [chemical binding]; other site
1074919001072 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1074919001073 ATP Binding subdomain [chemical binding]; other site
1074919001074 Ligand Binding sites [chemical binding]; other site
1074919001075 Dimerization subdomain; other site
1074919001076 PemK-like protein; Region: PemK; pfam02452
1074919001077 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1074919001078 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1074919001079 NADP binding site [chemical binding]; other site
1074919001080 superantigen-like protein; Reviewed; Region: PRK13037
1074919001081 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001082 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001083 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001084 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001085 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001086 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001087 superantigen-like protein; Reviewed; Region: PRK13042
1074919001088 Mucin-like glycoprotein; Region: Mucin; pfam01456
1074919001089 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001090 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001091 superantigen-like protein 5; Reviewed; Region: PRK13035
1074919001092 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001093 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001094 superantigen-like protein 7; Reviewed; Region: PRK13346
1074919001095 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001096 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001097 superantigen-like protein; Reviewed; Region: PRK13039
1074919001098 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001099 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001100 superantigen-like protein; Reviewed; Region: PRK13345
1074919001101 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001102 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001103 superantigen-like protein; Reviewed; Region: PRK13038
1074919001104 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001105 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001106 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1074919001107 HsdM N-terminal domain; Region: HsdM_N; pfam12161
1074919001108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919001109 S-adenosylmethionine binding site [chemical binding]; other site
1074919001110 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1074919001111 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1074919001112 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1074919001113 superantigen-like protein; Reviewed; Region: PRK13036
1074919001114 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
1074919001115 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919001116 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001117 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001118 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001119 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001120 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001121 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001122 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001123 Protein of unknown function, DUF576; Region: DUF576; cl04553
1074919001124 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001125 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001126 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919001127 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1074919001128 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1074919001129 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1074919001130 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1074919001131 NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1074919001132 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919001133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1074919001134 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1074919001135 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1074919001136 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1074919001137 active site
1074919001138 Esterase/lipase [General function prediction only]; Region: COG1647
1074919001139 Putative lysophospholipase; Region: Hydrolase_4; cl19140
1074919001140 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1074919001141 Na2 binding site [ion binding]; other site
1074919001142 putative substrate binding site 1 [chemical binding]; other site
1074919001143 Na binding site 1 [ion binding]; other site
1074919001144 putative substrate binding site 2 [chemical binding]; other site
1074919001145 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1074919001146 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1074919001147 dimer interface [polypeptide binding]; other site
1074919001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001149 catalytic residue [active]
1074919001150 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1074919001151 substrate-cofactor binding pocket; other site
1074919001152 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001153 catalytic residue [active]
1074919001154 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1074919001155 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1074919001156 Walker A/P-loop; other site
1074919001157 ATP binding site [chemical binding]; other site
1074919001158 Q-loop/lid; other site
1074919001159 ABC transporter signature motif; other site
1074919001160 Walker B; other site
1074919001161 D-loop; other site
1074919001162 H-loop/switch region; other site
1074919001163 NIL domain; Region: NIL; pfam09383
1074919001164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919001165 dimer interface [polypeptide binding]; other site
1074919001166 conserved gate region; other site
1074919001167 ABC-ATPase subunit interface; other site
1074919001168 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1074919001169 LysM domain; Region: LysM; pfam01476
1074919001170 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919001171 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919001172 Surface antigen [General function prediction only]; Region: COG3942
1074919001173 CHAP domain; Region: CHAP; pfam05257
1074919001174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919001175 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919001176 Coenzyme A binding pocket [chemical binding]; other site
1074919001177 Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1074919001178 Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1074919001179 Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919001180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919001181 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1074919001182 dimerization interface [polypeptide binding]; other site
1074919001183 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1074919001184 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1074919001185 active site
1074919001186 dimer interface [polypeptide binding]; other site
1074919001187 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1074919001188 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1074919001189 active site
1074919001190 FMN binding site [chemical binding]; other site
1074919001191 substrate binding site [chemical binding]; other site
1074919001192 3Fe-4S cluster binding site [ion binding]; other site
1074919001193 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1074919001194 domain interface; other site
1074919001195 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1074919001196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074919001197 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1074919001198 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919001199 active site turn [active]
1074919001200 phosphorylation site [posttranslational modification]
1074919001201 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919001202 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1074919001203 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1074919001204 Ca binding site [ion binding]; other site
1074919001205 active site
1074919001206 catalytic site [active]
1074919001207 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1074919001208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919001209 DNA-binding site [nucleotide binding]; DNA binding site
1074919001210 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1074919001211 UTRA domain; Region: UTRA; pfam07702
1074919001212 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919001213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919001214 Coenzyme A binding pocket [chemical binding]; other site
1074919001215 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1074919001216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919001217 Walker A motif; other site
1074919001218 ATP binding site [chemical binding]; other site
1074919001219 Walker B motif; other site
1074919001220 arginine finger; other site
1074919001221 recombination protein RecR; Reviewed; Region: recR; PRK00076
1074919001222 RecR protein; Region: RecR; pfam02132
1074919001223 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1074919001224 putative active site [active]
1074919001225 putative metal-binding site [ion binding]; other site
1074919001226 tetramer interface [polypeptide binding]; other site
1074919001227 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1074919001228 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1074919001229 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919001230 catalytic residue [active]
1074919001231 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1074919001232 thymidylate kinase; Validated; Region: tmk; PRK00698
1074919001233 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1074919001234 TMP-binding site; other site
1074919001235 ATP-binding site [chemical binding]; other site
1074919001236 DNA polymerase III subunit delta'; Validated; Region: PRK08058
1074919001237 DNA polymerase III subunit delta'; Validated; Region: PRK08485
1074919001238 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1074919001239 Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1074919001240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919001241 S-adenosylmethionine binding site [chemical binding]; other site
1074919001242 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1074919001243 putative SAM binding site [chemical binding]; other site
1074919001244 putative homodimer interface [polypeptide binding]; other site
1074919001245 methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1074919001246 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1074919001247 active site
1074919001248 HIGH motif; other site
1074919001249 KMSKS motif; other site
1074919001250 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1074919001251 tRNA binding surface [nucleotide binding]; other site
1074919001252 anticodon binding site; other site
1074919001253 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1074919001254 dimer interface [polypeptide binding]; other site
1074919001255 putative tRNA-binding site [nucleotide binding]; other site
1074919001256 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1074919001257 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1074919001258 active site
1074919001259 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1074919001260 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1074919001261 putative active site [active]
1074919001262 putative metal binding site [ion binding]; other site
1074919001263 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1074919001264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919001265 S-adenosylmethionine binding site [chemical binding]; other site
1074919001266 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1074919001267 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1074919001268 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1074919001269 pur operon repressor; Provisional; Region: PRK09213
1074919001270 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1074919001271 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919001272 active site
1074919001273 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1074919001274 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1074919001275 Substrate binding site; other site
1074919001276 Mg++ binding site; other site
1074919001277 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1074919001278 active site
1074919001279 substrate binding site [chemical binding]; other site
1074919001280 CoA binding site [chemical binding]; other site
1074919001281 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1074919001282 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1074919001283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919001284 active site
1074919001285 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1074919001286 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1074919001287 5S rRNA interface [nucleotide binding]; other site
1074919001288 CTC domain interface [polypeptide binding]; other site
1074919001289 L16 interface [polypeptide binding]; other site
1074919001290 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
1074919001291 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1074919001292 putative active site [active]
1074919001293 catalytic residue [active]
1074919001294 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1074919001295 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
1074919001296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919001297 ATP binding site [chemical binding]; other site
1074919001298 putative Mg++ binding site [ion binding]; other site
1074919001299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919001300 nucleotide binding region [chemical binding]; other site
1074919001301 ATP-binding site [chemical binding]; other site
1074919001302 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1074919001303 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1074919001304 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1074919001305 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
1074919001306 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1074919001307 putative SAM binding site [chemical binding]; other site
1074919001308 putative homodimer interface [polypeptide binding]; other site
1074919001309 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1074919001310 homodimer interface [polypeptide binding]; other site
1074919001311 metal binding site [ion binding]; metal-binding site
1074919001312 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1074919001313 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1074919001314 Ligand Binding Site [chemical binding]; other site
1074919001315 TilS substrate C-terminal domain; Region: TilS_C; smart00977
1074919001316 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919001317 active site
1074919001318 FtsH Extracellular; Region: FtsH_ext; pfam06480
1074919001319 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1074919001320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919001321 Walker A motif; other site
1074919001322 ATP binding site [chemical binding]; other site
1074919001323 Walker B motif; other site
1074919001324 arginine finger; other site
1074919001325 Peptidase family M41; Region: Peptidase_M41; pfam01434
1074919001326 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1074919001327 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1074919001328 dimerization interface [polypeptide binding]; other site
1074919001329 domain crossover interface; other site
1074919001330 redox-dependent activation switch; other site
1074919001331 cysteine synthase; Region: PLN02565
1074919001332 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1074919001333 dimer interface [polypeptide binding]; other site
1074919001334 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001335 catalytic residue [active]
1074919001336 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1074919001337 dihydropteroate synthase; Region: DHPS; TIGR01496
1074919001338 substrate binding pocket [chemical binding]; other site
1074919001339 dimer interface [polypeptide binding]; other site
1074919001340 inhibitor binding site; inhibition site
1074919001341 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1074919001342 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1074919001343 dimer interface [polypeptide binding]; other site
1074919001344 putative anticodon binding site; other site
1074919001345 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1074919001346 motif 1; other site
1074919001347 active site
1074919001348 motif 2; other site
1074919001349 motif 3; other site
1074919001350 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1074919001351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1074919001352 DNA-binding site [nucleotide binding]; DNA binding site
1074919001353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919001354 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001355 homodimer interface [polypeptide binding]; other site
1074919001356 catalytic residue [active]
1074919001357 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1074919001358 active site
1074919001359 multimer interface [polypeptide binding]; other site
1074919001360 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1074919001361 predicted active site [active]
1074919001362 catalytic triad [active]
1074919001363 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1074919001364 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1074919001365 Nucleoside recognition; Region: Gate; pfam07670
1074919001366 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1074919001367 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
1074919001368 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880
1074919001369 UvrB/uvrC motif; Region: UVR; pfam02151
1074919001370 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
1074919001371 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1074919001372 ADP binding site [chemical binding]; other site
1074919001373 phosphagen binding site; other site
1074919001374 substrate specificity loop; other site
1074919001375 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1074919001376 Clp amino terminal domain; Region: Clp_N; pfam02861
1074919001377 Clp amino terminal domain; Region: Clp_N; pfam02861
1074919001378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919001379 Walker A motif; other site
1074919001380 ATP binding site [chemical binding]; other site
1074919001381 Walker B motif; other site
1074919001382 arginine finger; other site
1074919001383 UvrB/uvrC motif; Region: UVR; pfam02151
1074919001384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919001385 Walker A motif; other site
1074919001386 ATP binding site [chemical binding]; other site
1074919001387 Walker B motif; other site
1074919001388 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1074919001389 DNA repair protein RadA; Provisional; Region: PRK11823
1074919001390 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1074919001391 Walker A motif/ATP binding site; other site
1074919001392 ATP binding site [chemical binding]; other site
1074919001393 Walker B motif; other site
1074919001394 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1074919001395 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1074919001396 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1074919001397 putative active site [active]
1074919001398 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1074919001399 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1074919001400 active site
1074919001401 HIGH motif; other site
1074919001402 KMSKS motif; other site
1074919001403 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1074919001404 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1074919001405 trimer interface [polypeptide binding]; other site
1074919001406 active site
1074919001407 substrate binding site [chemical binding]; other site
1074919001408 CoA binding site [chemical binding]; other site
1074919001409 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1074919001410 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1074919001411 active site
1074919001412 HIGH motif; other site
1074919001413 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1074919001414 KMSKS motif; other site
1074919001415 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1074919001416 tRNA binding surface [nucleotide binding]; other site
1074919001417 anticodon binding site; other site
1074919001418 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1074919001419 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1074919001420 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1074919001421 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
1074919001422 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1074919001423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074919001424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1074919001425 DNA binding residues [nucleotide binding]
1074919001426 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1074919001427 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1074919001428 putative homodimer interface [polypeptide binding]; other site
1074919001429 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1074919001430 heterodimer interface [polypeptide binding]; other site
1074919001431 homodimer interface [polypeptide binding]; other site
1074919001432 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1074919001433 mRNA/rRNA interface [nucleotide binding]; other site
1074919001434 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1074919001435 23S rRNA interface [nucleotide binding]; other site
1074919001436 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1074919001437 Methyltransferase domain; Region: Methyltransf_31; pfam13847
1074919001438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919001439 S-adenosylmethionine binding site [chemical binding]; other site
1074919001440 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1074919001441 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1074919001442 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1074919001443 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1074919001444 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1074919001445 RPB10 interaction site [polypeptide binding]; other site
1074919001446 RPB1 interaction site [polypeptide binding]; other site
1074919001447 RPB11 interaction site [polypeptide binding]; other site
1074919001448 RPB3 interaction site [polypeptide binding]; other site
1074919001449 RPB12 interaction site [polypeptide binding]; other site
1074919001450 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1074919001451 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1074919001452 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1074919001453 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1074919001454 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1074919001455 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1074919001456 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1074919001457 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1074919001458 G-loop; other site
1074919001459 DNA binding site [nucleotide binding]
1074919001460 30S ribosomal protein S7; Validated; Region: PRK05302
1074919001461 elongation factor G; Reviewed; Region: PRK00007
1074919001462 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1074919001463 G1 box; other site
1074919001464 putative GEF interaction site [polypeptide binding]; other site
1074919001465 GTP/Mg2+ binding site [chemical binding]; other site
1074919001466 Switch I region; other site
1074919001467 G2 box; other site
1074919001468 G3 box; other site
1074919001469 Switch II region; other site
1074919001470 G4 box; other site
1074919001471 G5 box; other site
1074919001472 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1074919001473 Elongation Factor G, domain II; Region: EFG_II; pfam14492
1074919001474 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1074919001475 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1074919001476 elongation factor Tu; Reviewed; Region: PRK00049
1074919001477 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1074919001478 G1 box; other site
1074919001479 GEF interaction site [polypeptide binding]; other site
1074919001480 GTP/Mg2+ binding site [chemical binding]; other site
1074919001481 Switch I region; other site
1074919001482 G2 box; other site
1074919001483 G3 box; other site
1074919001484 Switch II region; other site
1074919001485 G4 box; other site
1074919001486 G5 box; other site
1074919001487 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1074919001488 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1074919001489 Antibiotic Binding Site [chemical binding]; other site
1074919001490 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074919001491 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1074919001492 metal binding site [ion binding]; metal-binding site
1074919001493 dimer interface [polypeptide binding]; other site
1074919001494 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1074919001495 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1074919001496 substrate-cofactor binding pocket; other site
1074919001497 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001498 catalytic residue [active]
1074919001499 chaperone protein HchA; Provisional; Region: PRK04155
1074919001500 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
1074919001501 dimer interface [polypeptide binding]; other site
1074919001502 metal binding site [ion binding]; metal-binding site
1074919001503 potential oxyanion hole; other site
1074919001504 potential catalytic triad [active]
1074919001505 conserved cys residue [active]
1074919001506 ribulokinase; Provisional; Region: PRK04123
1074919001507 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1074919001508 N- and C-terminal domain interface [polypeptide binding]; other site
1074919001509 active site
1074919001510 MgATP binding site [chemical binding]; other site
1074919001511 catalytic site [active]
1074919001512 metal binding site [ion binding]; metal-binding site
1074919001513 carbohydrate binding site [chemical binding]; other site
1074919001514 homodimer interface [polypeptide binding]; other site
1074919001515 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1074919001516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919001517 NAD(P) binding site [chemical binding]; other site
1074919001518 active site
1074919001519 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1074919001520 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1074919001521 homodimer interface [polypeptide binding]; other site
1074919001522 substrate-cofactor binding pocket; other site
1074919001523 catalytic residue [active]
1074919001524 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1074919001525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001526 motif II; other site
1074919001527 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1074919001528 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1074919001529 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1074919001530 Substrate-binding site [chemical binding]; other site
1074919001531 Substrate specificity [chemical binding]; other site
1074919001532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001533 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1074919001534 active site
1074919001535 motif I; other site
1074919001536 motif II; other site
1074919001537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001538 Predicted flavoprotein [General function prediction only]; Region: COG0431
1074919001539 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919001540 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919001541 Cna protein B-type domain; Region: Cna_B; pfam05738
1074919001542 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001543 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919001544 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919001545 Cna protein B-type domain; Region: Cna_B; pfam05738
1074919001546 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001547 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001548 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001549 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001550 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919001551 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919001552 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1074919001553 Cna protein B-type domain; Region: Cna_B; pfam05738
1074919001554 Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1074919001555 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1074919001556 accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1074919001557 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949
1074919001558 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1074919001559 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949
1074919001560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1074919001561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919001562 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
1074919001563 Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919001564 putative GTP cyclohydrolase; Provisional; Region: PRK13674
1074919001565 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
1074919001566 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1074919001567 active site
1074919001568 trimer interface [polypeptide binding]; other site
1074919001569 allosteric site; other site
1074919001570 active site lid [active]
1074919001571 hexamer (dimer of trimers) interface [polypeptide binding]; other site
1074919001572 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1074919001573 active site
1074919001574 dimer interface [polypeptide binding]; other site
1074919001575 magnesium binding site [ion binding]; other site
1074919001576 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1074919001577 tetramer interface [polypeptide binding]; other site
1074919001578 Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919001579 active site
1074919001580 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1074919001581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001582 motif II; other site
1074919001583 proline/glycine betaine transporter; Provisional; Region: PRK10642
1074919001584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919001585 putative substrate translocation pore; other site
1074919001586 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1074919001587 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1074919001588 acyl-activating enzyme (AAE) consensus motif; other site
1074919001589 AMP binding site [chemical binding]; other site
1074919001590 active site
1074919001591 CoA binding site [chemical binding]; other site
1074919001592 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1074919001593 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1074919001594 dimer interface [polypeptide binding]; other site
1074919001595 active site
1074919001596 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1074919001597 dimer interface [polypeptide binding]; other site
1074919001598 substrate binding site [chemical binding]; other site
1074919001599 ATP binding site [chemical binding]; other site
1074919001600 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1074919001601 ligand binding site [chemical binding]; other site
1074919001602 active site
1074919001603 UGI interface [polypeptide binding]; other site
1074919001604 catalytic site [active]
1074919001605 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1074919001606 Uncharacterized conserved protein [Function unknown]; Region: COG2966
1074919001607 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1074919001608 putative heme peroxidase; Provisional; Region: PRK12276
1074919001609 phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1074919001610 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1074919001611 mevalonate kinase; Region: mevalon_kin; TIGR00549
1074919001612 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1074919001613 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1074919001614 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
1074919001615 diphosphomevalonate decarboxylase; Region: PLN02407
1074919001616 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1074919001617 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1074919001618 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1074919001619 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1074919001620 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1074919001621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919001622 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074919001623 LXG domain of WXG superfamily; Region: LXG; pfam04740
1074919001624 Protein of unknown function (DUF443); Region: DUF443; pfam04276
1074919001625 Protein of unknown function (DUF443); Region: DUF443; pfam04276
1074919001626 Protein of unknown function (DUF443); Region: DUF443; pfam04276
1074919001627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919001628 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1074919001629 active site
1074919001630 catalytic tetrad [active]
1074919001631 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1074919001632 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1074919001633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1074919001634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919001635 Coenzyme A binding pocket [chemical binding]; other site
1074919001636 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1074919001637 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919001638 Zn2+ binding site [ion binding]; other site
1074919001639 Mg2+ binding site [ion binding]; other site
1074919001640 YwhD family; Region: YwhD; pfam08741
1074919001641 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1074919001642 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1074919001643 NAD binding site [chemical binding]; other site
1074919001644 substrate binding site [chemical binding]; other site
1074919001645 catalytic Zn binding site [ion binding]; other site
1074919001646 tetramer interface [polypeptide binding]; other site
1074919001647 structural Zn binding site [ion binding]; other site
1074919001648 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1074919001649 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
1074919001650 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1074919001651 active site
1074919001652 HIGH motif; other site
1074919001653 KMSK motif region; other site
1074919001654 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1074919001655 tRNA binding surface [nucleotide binding]; other site
1074919001656 anticodon binding site; other site
1074919001657 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
1074919001658 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1074919001659 minor groove reading motif; other site
1074919001660 helix-hairpin-helix signature motif; other site
1074919001661 substrate binding pocket [chemical binding]; other site
1074919001662 active site
1074919001663 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1074919001664 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1074919001665 putative binding site residues; other site
1074919001666 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1074919001667 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001668 ABC-ATPase subunit interface; other site
1074919001669 dimer interface [polypeptide binding]; other site
1074919001670 putative PBP binding regions; other site
1074919001671 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1074919001672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919001673 motif II; other site
1074919001674 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1074919001675 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074919001676 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1074919001677 Putative lysophospholipase; Region: Hydrolase_4; cl19140
1074919001678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1074919001679 Protein of unknown function, DUF606; Region: DUF606; pfam04657
1074919001680 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919001681 active site
1074919001682 DNA binding site [nucleotide binding]
1074919001683 Int/Topo IB signature motif; other site
1074919001684 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
1074919001685 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919001686 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1074919001687 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
1074919001688 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919001689 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1074919001690 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
1074919001691 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1074919001692 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1074919001693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919001694 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
1074919001695 Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919001696 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074919001697 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1074919001698 intersubunit interface [polypeptide binding]; other site
1074919001699 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1074919001700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001701 ABC-ATPase subunit interface; other site
1074919001702 dimer interface [polypeptide binding]; other site
1074919001703 putative PBP binding regions; other site
1074919001704 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1074919001705 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1074919001706 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1074919001707 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1074919001708 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
1074919001709 FeoA domain; Region: FeoA; pfam04023
1074919001710 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1074919001711 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1074919001712 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1074919001713 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
1074919001714 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1074919001715 Walker A/P-loop; other site
1074919001716 ATP binding site [chemical binding]; other site
1074919001717 Q-loop/lid; other site
1074919001718 ABC transporter signature motif; other site
1074919001719 Walker B; other site
1074919001720 D-loop; other site
1074919001721 H-loop/switch region; other site
1074919001722 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1074919001723 ABC-2 type transporter; Region: ABC2_membrane; cl17235
1074919001724 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919001725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1074919001726 active site
1074919001727 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1074919001728 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
1074919001729 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
1074919001730 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1074919001731 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919001732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919001733 Walker A/P-loop; other site
1074919001734 ATP binding site [chemical binding]; other site
1074919001735 Q-loop/lid; other site
1074919001736 ABC transporter signature motif; other site
1074919001737 Walker B; other site
1074919001738 D-loop; other site
1074919001739 H-loop/switch region; other site
1074919001740 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1074919001741 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1074919001742 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1074919001743 Uncharacterized conserved protein [Function unknown]; Region: COG1284
1074919001744 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1074919001745 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1074919001746 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074919001747 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074919001748 Walker A/P-loop; other site
1074919001749 ATP binding site [chemical binding]; other site
1074919001750 Q-loop/lid; other site
1074919001751 ABC transporter signature motif; other site
1074919001752 Walker B; other site
1074919001753 D-loop; other site
1074919001754 H-loop/switch region; other site
1074919001755 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001756 ABC-ATPase subunit interface; other site
1074919001757 dimer interface [polypeptide binding]; other site
1074919001758 putative PBP binding regions; other site
1074919001759 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1074919001760 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001761 ABC-ATPase subunit interface; other site
1074919001762 dimer interface [polypeptide binding]; other site
1074919001763 putative PBP binding regions; other site
1074919001764 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1074919001765 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1074919001766 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1074919001767 Uncharacterized membrane protein [Function unknown]; Region: COG3949
1074919001768 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1074919001769 Na binding site [ion binding]; other site
1074919001770 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1074919001771 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1074919001772 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919001773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919001774 Coenzyme A binding pocket [chemical binding]; other site
1074919001775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919001776 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1074919001777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919001778 NAD(P) binding site [chemical binding]; other site
1074919001779 active site
1074919001780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919001781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919001782 active site
1074919001783 phosphorylation site [posttranslational modification]
1074919001784 intermolecular recognition site; other site
1074919001785 dimerization interface [polypeptide binding]; other site
1074919001786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919001787 DNA binding site [nucleotide binding]
1074919001788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919001789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1074919001790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919001791 ATP binding site [chemical binding]; other site
1074919001792 Mg2+ binding site [ion binding]; other site
1074919001793 G-X-G motif; other site
1074919001794 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919001795 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919001796 Walker A/P-loop; other site
1074919001797 ATP binding site [chemical binding]; other site
1074919001798 Q-loop/lid; other site
1074919001799 ABC transporter signature motif; other site
1074919001800 Walker B; other site
1074919001801 D-loop; other site
1074919001802 H-loop/switch region; other site
1074919001803 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1074919001804 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1074919001805 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919001806 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1074919001807 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919001808 Surface antigen [General function prediction only]; Region: COG3942
1074919001809 CHAP domain; Region: CHAP; pfam05257
1074919001810 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1074919001811 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1074919001812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919001813 hypothetical protein; Provisional; Region: PRK12378
1074919001814 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
1074919001815 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1074919001816 Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919001817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919001818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1074919001819 dimerization interface [polypeptide binding]; other site
1074919001820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919001821 sugar efflux transporter; Region: 2A0120; TIGR00899
1074919001822 putative substrate translocation pore; other site
1074919001823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
1074919001824 Serine incorporator (Serinc); Region: Serinc; pfam03348
1074919001825 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1074919001826 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1074919001827 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
1074919001828 hypothetical protein; Validated; Region: PRK00124
1074919001829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1074919001830 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1074919001831 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1074919001832 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919001833 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1074919001834 Walker A/P-loop; other site
1074919001835 ATP binding site [chemical binding]; other site
1074919001836 Q-loop/lid; other site
1074919001837 ABC transporter signature motif; other site
1074919001838 Walker B; other site
1074919001839 D-loop; other site
1074919001840 H-loop/switch region; other site
1074919001841 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1074919001842 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919001843 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1074919001844 Walker A/P-loop; other site
1074919001845 ATP binding site [chemical binding]; other site
1074919001846 Q-loop/lid; other site
1074919001847 ABC transporter signature motif; other site
1074919001848 Walker B; other site
1074919001849 D-loop; other site
1074919001850 H-loop/switch region; other site
1074919001851 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1074919001852 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1074919001853 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1074919001854 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919001855 active site
1074919001856 catalytic tetrad [active]
1074919001857 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1074919001858 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1074919001859 transmembrane helices; other site
1074919001860 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1074919001861 DNA photolyase; Region: DNA_photolyase; pfam00875
1074919001862 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
1074919001863 Predicted membrane protein [Function unknown]; Region: COG4330
1074919001864 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1074919001865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919001866 putative substrate translocation pore; other site
1074919001867 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1074919001868 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1074919001869 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1074919001870 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1074919001871 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1074919001872 putative substrate binding site [chemical binding]; other site
1074919001873 putative ATP binding site [chemical binding]; other site
1074919001874 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1074919001875 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919001876 active site
1074919001877 phosphorylation site [posttranslational modification]
1074919001878 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1074919001879 active site
1074919001880 P-loop; other site
1074919001881 phosphorylation site [posttranslational modification]
1074919001882 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1074919001883 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1074919001884 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1074919001885 active site
1074919001886 dimer interface [polypeptide binding]; other site
1074919001887 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1074919001888 Domain of unknown function DUF21; Region: DUF21; pfam01595
1074919001889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1074919001890 Transporter associated domain; Region: CorC_HlyC; pfam03471
1074919001891 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919001892 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1074919001893 active site
1074919001894 catalytic tetrad [active]
1074919001895 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1074919001896 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1074919001897 Ligand binding site; other site
1074919001898 Putative Catalytic site; other site
1074919001899 DXD motif; other site
1074919001900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919001901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919001902 dimer interface [polypeptide binding]; other site
1074919001903 phosphorylation site [posttranslational modification]
1074919001904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919001905 ATP binding site [chemical binding]; other site
1074919001906 Mg2+ binding site [ion binding]; other site
1074919001907 G-X-G motif; other site
1074919001908 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919001909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919001910 active site
1074919001911 phosphorylation site [posttranslational modification]
1074919001912 intermolecular recognition site; other site
1074919001913 dimerization interface [polypeptide binding]; other site
1074919001914 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919001915 DNA binding site [nucleotide binding]
1074919001916 Predicted membrane protein [Function unknown]; Region: COG2259
1074919001917 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1074919001918 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1074919001919 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1074919001920 Ligand Binding Site [chemical binding]; other site
1074919001921 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1074919001922 Glutamine amidotransferase class-I; Region: GATase; pfam00117
1074919001923 glutamine binding [chemical binding]; other site
1074919001924 catalytic triad [active]
1074919001925 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1074919001926 chorismate binding enzyme; Region: Chorismate_bind; cl10555
1074919001927 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1074919001928 substrate-cofactor binding pocket; other site
1074919001929 Aminotransferase class IV; Region: Aminotran_4; pfam01063
1074919001930 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001931 catalytic residue [active]
1074919001932 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1074919001933 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1074919001934 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1074919001935 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1074919001936 Sulfatase; Region: Sulfatase; pfam00884
1074919001937 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1074919001938 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919001939 ABC transporter; Region: ABC_tran_2; pfam12848
1074919001940 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919001941 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1074919001942 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919001943 ATP binding site [chemical binding]; other site
1074919001944 putative Mg++ binding site [ion binding]; other site
1074919001945 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919001946 nucleotide binding region [chemical binding]; other site
1074919001947 ATP-binding site [chemical binding]; other site
1074919001948 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1074919001949 HRDC domain; Region: HRDC; pfam00570
1074919001950 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1074919001951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919001952 Walker A/P-loop; other site
1074919001953 ATP binding site [chemical binding]; other site
1074919001954 Q-loop/lid; other site
1074919001955 ABC transporter signature motif; other site
1074919001956 Walker B; other site
1074919001957 D-loop; other site
1074919001958 H-loop/switch region; other site
1074919001959 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1074919001960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919001961 dimer interface [polypeptide binding]; other site
1074919001962 conserved gate region; other site
1074919001963 ABC-ATPase subunit interface; other site
1074919001964 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1074919001965 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1074919001966 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1074919001967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919001968 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919001969 homodimer interface [polypeptide binding]; other site
1074919001970 catalytic residue [active]
1074919001971 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
1074919001972 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1074919001973 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1074919001974 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1074919001975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919001976 putative substrate translocation pore; other site
1074919001977 POT family; Region: PTR2; cl17359
1074919001978 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1074919001979 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1074919001980 EamA-like transporter family; Region: EamA; pfam00892
1074919001981 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
1074919001982 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1074919001983 Class I ribonucleotide reductase; Region: RNR_I; cd01679
1074919001984 active site
1074919001985 dimer interface [polypeptide binding]; other site
1074919001986 catalytic residues [active]
1074919001987 effector binding site; other site
1074919001988 R2 peptide binding site; other site
1074919001989 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1074919001990 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1074919001991 dimer interface [polypeptide binding]; other site
1074919001992 putative radical transfer pathway; other site
1074919001993 diiron center [ion binding]; other site
1074919001994 tyrosyl radical; other site
1074919001995 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919001996 ABC-ATPase subunit interface; other site
1074919001997 dimer interface [polypeptide binding]; other site
1074919001998 putative PBP binding regions; other site
1074919001999 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1074919002000 ABC-ATPase subunit interface; other site
1074919002001 dimer interface [polypeptide binding]; other site
1074919002002 putative PBP binding regions; other site
1074919002003 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1074919002004 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1074919002005 Walker A/P-loop; other site
1074919002006 ATP binding site [chemical binding]; other site
1074919002007 Q-loop/lid; other site
1074919002008 ABC transporter signature motif; other site
1074919002009 Walker B; other site
1074919002010 D-loop; other site
1074919002011 H-loop/switch region; other site
1074919002012 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1074919002013 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1074919002014 putative ligand binding residues [chemical binding]; other site
1074919002015 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
1074919002016 FAD binding domain; Region: FAD_binding_4; pfam01565
1074919002017 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1074919002018 GrpB protein; Region: GrpB; pfam04229
1074919002019 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1074919002020 peptidase T; Region: peptidase-T; TIGR01882
1074919002021 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1074919002022 metal binding site [ion binding]; metal-binding site
1074919002023 dimer interface [polypeptide binding]; other site
1074919002024 Uncharacterized conserved protein [Function unknown]; Region: COG3610
1074919002025 Uncharacterized conserved protein [Function unknown]; Region: COG2966
1074919002026 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1074919002027 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1074919002028 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199
1074919002029 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1074919002030 metal binding site [ion binding]; metal-binding site
1074919002031 active site
1074919002032 I-site; other site
1074919002033 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1074919002034 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1074919002035 Mg++ binding site [ion binding]; other site
1074919002036 putative catalytic motif [active]
1074919002037 substrate binding site [chemical binding]; other site
1074919002038 Uncharacterized conserved protein [Function unknown]; Region: COG1739
1074919002039 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1074919002040 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1074919002041 EDD domain protein, DegV family; Region: DegV; TIGR00762
1074919002042 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1074919002043 DEAD-like helicases superfamily; Region: DEXDc; smart00487
1074919002044 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919002045 ATP binding site [chemical binding]; other site
1074919002046 putative Mg++ binding site [ion binding]; other site
1074919002047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919002048 nucleotide binding region [chemical binding]; other site
1074919002049 ATP-binding site [chemical binding]; other site
1074919002050 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1074919002051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919002052 active site
1074919002053 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1074919002054 30S subunit binding site; other site
1074919002055 preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1074919002056 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1074919002057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1074919002058 nucleotide binding region [chemical binding]; other site
1074919002059 ATP-binding site [chemical binding]; other site
1074919002060 SEC-C motif; Region: SEC-C; pfam02810
1074919002061 peptide chain release factor 2; Provisional; Region: PRK06746
1074919002062 This domain is found in peptide chain release factors; Region: PCRF; smart00937
1074919002063 RF-1 domain; Region: RF-1; pfam00472
1074919002064 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1074919002065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919002066 Surface antigen [General function prediction only]; Region: COG3942
1074919002067 CHAP domain; Region: CHAP; pfam05257
1074919002068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919002069 Zn2+ binding site [ion binding]; other site
1074919002070 Mg2+ binding site [ion binding]; other site
1074919002071 excinuclease ABC subunit B; Provisional; Region: PRK05298
1074919002072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919002073 ATP binding site [chemical binding]; other site
1074919002074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919002075 nucleotide binding region [chemical binding]; other site
1074919002076 ATP-binding site [chemical binding]; other site
1074919002077 Ultra-violet resistance protein B; Region: UvrB; pfam12344
1074919002078 UvrB/uvrC motif; Region: UVR; pfam02151
1074919002079 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1074919002080 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1074919002081 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1074919002082 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1074919002083 HPr kinase/phosphorylase; Provisional; Region: PRK05428
1074919002084 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1074919002085 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1074919002086 Hpr binding site; other site
1074919002087 active site
1074919002088 homohexamer subunit interaction site [polypeptide binding]; other site
1074919002089 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1074919002090 putative acyl transferase; Provisional; Region: PRK10191
1074919002091 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1074919002092 putative trimer interface [polypeptide binding]; other site
1074919002093 putative CoA binding site [chemical binding]; other site
1074919002094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919002095 binding surface
1074919002096 TPR motif; other site
1074919002097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919002098 TPR motif; other site
1074919002099 binding surface
1074919002100 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1074919002101 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1074919002102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002103 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
1074919002104 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1074919002105 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
1074919002106 dimer interface [polypeptide binding]; other site
1074919002107 phosphate binding site [ion binding]; other site
1074919002108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1074919002109 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1074919002110 Clp protease; Region: CLP_protease; pfam00574
1074919002111 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1074919002112 oligomer interface [polypeptide binding]; other site
1074919002113 active site residues [active]
1074919002114 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1074919002115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919002116 NAD(P) binding site [chemical binding]; other site
1074919002117 active site
1074919002118 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1074919002119 Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1074919002120 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1074919002121 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1074919002122 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1074919002123 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1074919002124 substrate binding site [chemical binding]; other site
1074919002125 hinge regions; other site
1074919002126 ADP binding site [chemical binding]; other site
1074919002127 catalytic site [active]
1074919002128 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1074919002129 triosephosphate isomerase; Provisional; Region: PRK14565
1074919002130 substrate binding site [chemical binding]; other site
1074919002131 dimer interface [polypeptide binding]; other site
1074919002132 catalytic triad [active]
1074919002133 phosphoglyceromutase; Provisional; Region: PRK05434
1074919002134 enolase; Provisional; Region: eno; PRK00077
1074919002135 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1074919002136 dimer interface [polypeptide binding]; other site
1074919002137 metal binding site [ion binding]; metal-binding site
1074919002138 substrate binding pocket [chemical binding]; other site
1074919002139 Esterase/lipase [General function prediction only]; Region: COG1647
1074919002140 ribonuclease R; Region: RNase_R; TIGR02063
1074919002141 Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1074919002142 Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1074919002143 RNB domain; Region: RNB; pfam00773
1074919002144 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1074919002145 RNA binding site [nucleotide binding]; other site
1074919002146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919002147 Coenzyme A binding pocket [chemical binding]; other site
1074919002148 Transposase, Mutator family; Region: Transposase_mut; pfam00872
1074919002149 MULE transposase domain; Region: MULE; pfam10551
1074919002150 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919002151 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
1074919002152 Staphylococcal nuclease homologues; Region: SNc; smart00318
1074919002153 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1074919002154 Catalytic site; other site
1074919002155 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
1074919002156 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074919002157 catalytic core [active]
1074919002158 Lysine efflux permease [General function prediction only]; Region: COG1279
1074919002159 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1074919002160 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1074919002161 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1074919002162 active site
1074919002163 catalytic residue [active]
1074919002164 dimer interface [polypeptide binding]; other site
1074919002165 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1074919002166 putative FMN binding site [chemical binding]; other site
1074919002167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
1074919002168 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235
1074919002169 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1074919002170 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1074919002171 Int/Topo IB signature motif; other site
1074919002172 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919002173 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919002174 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919002175 active site
1074919002176 DNA binding site [nucleotide binding]
1074919002177 Int/Topo IB signature motif; other site
1074919002178 aminoglycoside resistance protein; Provisional; Region: PRK13746
1074919002179 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1074919002180 active site
1074919002181 NTP binding site [chemical binding]; other site
1074919002182 metal binding triad [ion binding]; metal-binding site
1074919002183 antibiotic binding site [chemical binding]; other site
1074919002184 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1074919002185 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1074919002186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919002187 S-adenosylmethionine binding site [chemical binding]; other site
1074919002188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919002189 S-adenosylmethionine binding site [chemical binding]; other site
1074919002190 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1074919002191 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1074919002192 Walker A/P-loop; other site
1074919002193 ATP binding site [chemical binding]; other site
1074919002194 Q-loop/lid; other site
1074919002195 ABC transporter signature motif; other site
1074919002196 Walker B; other site
1074919002197 D-loop; other site
1074919002198 H-loop/switch region; other site
1074919002199 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1074919002200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002201 dimer interface [polypeptide binding]; other site
1074919002202 conserved gate region; other site
1074919002203 putative PBP binding loops; other site
1074919002204 ABC-ATPase subunit interface; other site
1074919002205 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1074919002206 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1074919002207 Predicted membrane protein [Function unknown]; Region: COG2035
1074919002208 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1074919002209 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1074919002210 Walker A/P-loop; other site
1074919002211 ATP binding site [chemical binding]; other site
1074919002212 Q-loop/lid; other site
1074919002213 ABC transporter signature motif; other site
1074919002214 Walker B; other site
1074919002215 D-loop; other site
1074919002216 H-loop/switch region; other site
1074919002217 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1074919002218 FeS assembly protein SufD; Region: sufD; TIGR01981
1074919002219 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1074919002220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919002221 catalytic residue [active]
1074919002222 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1074919002223 trimerization site [polypeptide binding]; other site
1074919002224 active site
1074919002225 FeS assembly protein SufB; Region: sufB; TIGR01980
1074919002226 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1074919002227 Domain of unknown function DUF21; Region: DUF21; pfam01595
1074919002228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1074919002229 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1074919002230 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1074919002231 FMN binding site [chemical binding]; other site
1074919002232 substrate binding site [chemical binding]; other site
1074919002233 putative catalytic residue [active]
1074919002234 Uncharacterized conserved protein [Function unknown]; Region: COG1801
1074919002235 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1074919002236 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1074919002237 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1074919002238 active site
1074919002239 metal binding site [ion binding]; metal-binding site
1074919002240 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1074919002241 lipoyl synthase; Provisional; Region: PRK05481
1074919002242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919002243 FeS/SAM binding site; other site
1074919002244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919002245 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
1074919002246 Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919002247 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1074919002248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919002249 active site
1074919002250 motif I; other site
1074919002251 motif II; other site
1074919002252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919002253 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1074919002254 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1074919002255 dimerization interface [polypeptide binding]; other site
1074919002256 ligand binding site [chemical binding]; other site
1074919002257 NADP binding site [chemical binding]; other site
1074919002258 catalytic site [active]
1074919002259 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1074919002260 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1074919002261 acyl-activating enzyme (AAE) consensus motif; other site
1074919002262 AMP binding site [chemical binding]; other site
1074919002263 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1074919002264 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1074919002265 DltD N-terminal region; Region: DltD_N; pfam04915
1074919002266 DltD central region; Region: DltD_M; pfam04918
1074919002267 DltD C-terminal region; Region: DltD_C; pfam04914
1074919002268 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1074919002269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002270 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1074919002271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002272 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
1074919002273 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1074919002274 interface (dimer of trimers) [polypeptide binding]; other site
1074919002275 Substrate-binding/catalytic site; other site
1074919002276 Zn-binding sites [ion binding]; other site
1074919002277 Predicted permease [General function prediction only]; Region: COG2056
1074919002278 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1074919002279 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
1074919002280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919002281 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1074919002282 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
1074919002283 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
1074919002284 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919002285 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
1074919002286 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1074919002287 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1074919002288 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1074919002289 active site
1074919002290 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1074919002291 putative active site [active]
1074919002292 putative FMN binding site [chemical binding]; other site
1074919002293 putative substrate binding site [chemical binding]; other site
1074919002294 putative catalytic residue [active]
1074919002295 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919002296 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1074919002297 inhibitor-cofactor binding pocket; inhibition site
1074919002298 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919002299 catalytic residue [active]
1074919002300 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1074919002301 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
1074919002302 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1074919002303 NAD(P) binding site [chemical binding]; other site
1074919002304 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919002305 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1074919002306 active site
1074919002307 catalytic site [active]
1074919002308 metal binding site [ion binding]; metal-binding site
1074919002309 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165
1074919002310 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1074919002311 active sites [active]
1074919002312 tetramer interface [polypeptide binding]; other site
1074919002313 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999
1074919002314 ANP binding site [chemical binding]; other site
1074919002315 Substrate Binding Site II [chemical binding]; other site
1074919002316 Substrate Binding Site I [chemical binding]; other site
1074919002317 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1074919002318 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1074919002319 active site
1074919002320 dimer interface [polypeptide binding]; other site
1074919002321 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1074919002322 dimer interface [polypeptide binding]; other site
1074919002323 active site
1074919002324 Uncharacterized conserved protein [Function unknown]; Region: COG0398
1074919002325 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1074919002326 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1074919002327 Catalytic site [active]
1074919002328 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1074919002329 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1074919002330 Catalytic site [active]
1074919002331 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1074919002332 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1074919002333 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1074919002334 Part of AAA domain; Region: AAA_19; pfam13245
1074919002335 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
1074919002336 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1074919002337 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1074919002338 coenzyme A disulfide reductase; Provisional; Region: PRK13512
1074919002339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919002340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002341 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1074919002342 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1074919002343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919002344 active site
1074919002345 motif I; other site
1074919002346 motif II; other site
1074919002347 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1074919002348 Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1074919002349 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1074919002350 catalytic triad [active]
1074919002351 catalytic triad [active]
1074919002352 oxyanion hole [active]
1074919002353 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1074919002354 Clp amino terminal domain; Region: Clp_N; pfam02861
1074919002355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919002356 Walker A motif; other site
1074919002357 ATP binding site [chemical binding]; other site
1074919002358 Walker B motif; other site
1074919002359 arginine finger; other site
1074919002360 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1074919002361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919002362 Walker A motif; other site
1074919002363 ATP binding site [chemical binding]; other site
1074919002364 Walker B motif; other site
1074919002365 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1074919002366 Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919002367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919002368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1074919002369 dimerization interface [polypeptide binding]; other site
1074919002370 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1074919002371 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962
1074919002372 active site
1074919002373 catalytic residues [active]
1074919002374 metal binding site [ion binding]; metal-binding site
1074919002375 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1074919002376 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1074919002377 substrate binding site [chemical binding]; other site
1074919002378 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1074919002379 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1074919002380 dimer interface [polypeptide binding]; other site
1074919002381 active site
1074919002382 CoA binding pocket [chemical binding]; other site
1074919002383 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1074919002384 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1074919002385 dimer interface [polypeptide binding]; other site
1074919002386 active site
1074919002387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919002388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002389 dimer interface [polypeptide binding]; other site
1074919002390 conserved gate region; other site
1074919002391 putative PBP binding loops; other site
1074919002392 ABC-ATPase subunit interface; other site
1074919002393 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1074919002394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002395 dimer interface [polypeptide binding]; other site
1074919002396 conserved gate region; other site
1074919002397 putative PBP binding loops; other site
1074919002398 ABC-ATPase subunit interface; other site
1074919002399 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1074919002400 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919002401 Walker A/P-loop; other site
1074919002402 ATP binding site [chemical binding]; other site
1074919002403 Q-loop/lid; other site
1074919002404 ABC transporter signature motif; other site
1074919002405 Walker B; other site
1074919002406 D-loop; other site
1074919002407 H-loop/switch region; other site
1074919002408 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074919002409 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1074919002410 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919002411 Walker A/P-loop; other site
1074919002412 ATP binding site [chemical binding]; other site
1074919002413 Q-loop/lid; other site
1074919002414 ABC transporter signature motif; other site
1074919002415 Walker B; other site
1074919002416 D-loop; other site
1074919002417 H-loop/switch region; other site
1074919002418 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074919002419 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1074919002420 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1074919002421 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1074919002422 peptide binding site [polypeptide binding]; other site
1074919002423 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074919002424 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
1074919002425 peptide binding site [polypeptide binding]; other site
1074919002426 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1074919002427 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919002428 Walker A/P-loop; other site
1074919002429 ATP binding site [chemical binding]; other site
1074919002430 Q-loop/lid; other site
1074919002431 ABC transporter signature motif; other site
1074919002432 Walker B; other site
1074919002433 D-loop; other site
1074919002434 H-loop/switch region; other site
1074919002435 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074919002436 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1074919002437 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919002438 Walker A/P-loop; other site
1074919002439 ATP binding site [chemical binding]; other site
1074919002440 Q-loop/lid; other site
1074919002441 ABC transporter signature motif; other site
1074919002442 Walker B; other site
1074919002443 D-loop; other site
1074919002444 H-loop/switch region; other site
1074919002445 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1074919002446 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919002447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002448 dimer interface [polypeptide binding]; other site
1074919002449 conserved gate region; other site
1074919002450 putative PBP binding loops; other site
1074919002451 ABC-ATPase subunit interface; other site
1074919002452 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1074919002453 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1074919002454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002455 dimer interface [polypeptide binding]; other site
1074919002456 conserved gate region; other site
1074919002457 putative PBP binding loops; other site
1074919002458 ABC-ATPase subunit interface; other site
1074919002459 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
1074919002460 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1074919002461 active site
1074919002462 HIGH motif; other site
1074919002463 dimer interface [polypeptide binding]; other site
1074919002464 KMSKS motif; other site
1074919002465 adaptor protein; Provisional; Region: PRK02315
1074919002466 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469
1074919002467 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1074919002468 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1074919002469 active site
1074919002470 Zn binding site [ion binding]; other site
1074919002471 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1074919002472 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1074919002473 catalytic residues [active]
1074919002474 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1074919002475 putative active site [active]
1074919002476 putative metal binding residues [ion binding]; other site
1074919002477 signature motif; other site
1074919002478 putative triphosphate binding site [ion binding]; other site
1074919002479 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1074919002480 synthetase active site [active]
1074919002481 NTP binding site [chemical binding]; other site
1074919002482 metal binding site [ion binding]; metal-binding site
1074919002483 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1074919002484 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1074919002485 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1074919002486 active site
1074919002487 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1074919002488 MgtE intracellular N domain; Region: MgtE_N; smart00924
1074919002489 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1074919002490 Divalent cation transporter; Region: MgtE; pfam01769
1074919002491 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1074919002492 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1074919002493 TrkA-N domain; Region: TrkA_N; pfam02254
1074919002494 TrkA-C domain; Region: TrkA_C; pfam02080
1074919002495 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1074919002496 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1074919002497 NAD binding site [chemical binding]; other site
1074919002498 homotetramer interface [polypeptide binding]; other site
1074919002499 homodimer interface [polypeptide binding]; other site
1074919002500 substrate binding site [chemical binding]; other site
1074919002501 active site
1074919002502 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1074919002503 Domain of unknown function DUF20; Region: UPF0118; pfam01594
1074919002504 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1074919002505 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1074919002506 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
1074919002507 Putative esterase; Region: Esterase; pfam00756
1074919002508 hypothetical protein; Provisional; Region: PRK13679
1074919002509 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1074919002510 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919002511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919002512 putative substrate translocation pore; other site
1074919002513 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
1074919002514 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1074919002515 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1074919002516 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1074919002517 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1074919002518 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919002519 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919002520 peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1074919002521 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1074919002522 G1 box; other site
1074919002523 putative GEF interaction site [polypeptide binding]; other site
1074919002524 GTP/Mg2+ binding site [chemical binding]; other site
1074919002525 Switch I region; other site
1074919002526 G2 box; other site
1074919002527 G3 box; other site
1074919002528 Switch II region; other site
1074919002529 G4 box; other site
1074919002530 G5 box; other site
1074919002531 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1074919002532 Elongation Factor G, domain II; Region: EFG_II; pfam14492
1074919002533 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1074919002534 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1074919002535 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1074919002536 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1074919002537 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1074919002538 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1074919002539 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1074919002540 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1074919002541 active site
1074919002542 metal binding site [ion binding]; metal-binding site
1074919002543 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1074919002544 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
1074919002545 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1074919002546 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1074919002547 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1074919002548 CAAX protease self-immunity; Region: Abi; pfam02517
1074919002549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
1074919002550 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
1074919002551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919002552 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1074919002553 Walker A/P-loop; other site
1074919002554 ATP binding site [chemical binding]; other site
1074919002555 Q-loop/lid; other site
1074919002556 ABC transporter signature motif; other site
1074919002557 Walker B; other site
1074919002558 D-loop; other site
1074919002559 H-loop/switch region; other site
1074919002560 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1074919002561 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1074919002562 siderophore binding site; other site
1074919002563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919002564 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919002565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919002566 Coenzyme A binding pocket [chemical binding]; other site
1074919002567 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1074919002568 UbiA prenyltransferase family; Region: UbiA; pfam01040
1074919002569 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1074919002570 isochorismate synthases; Region: isochor_syn; TIGR00543
1074919002571 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1074919002572 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1074919002573 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1074919002574 TPP-binding site; other site
1074919002575 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1074919002576 PGAP1-like protein; Region: PGAP1; pfam07819
1074919002577 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1074919002578 substrate binding site [chemical binding]; other site
1074919002579 oxyanion hole (OAH) forming residues; other site
1074919002580 trimer interface [polypeptide binding]; other site
1074919002581 Staphopain proregion; Region: Staphopain_pro; pfam14731
1074919002582 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1074919002583 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919002584 aminotransferase A; Validated; Region: PRK07683
1074919002585 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919002586 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919002587 homodimer interface [polypeptide binding]; other site
1074919002588 catalytic residue [active]
1074919002589 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1074919002590 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1074919002591 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1074919002592 amidase catalytic site [active]
1074919002593 Zn binding residues [ion binding]; other site
1074919002594 substrate binding site [chemical binding]; other site
1074919002595 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1074919002596 Lysozyme subfamily 2; Region: LYZ2; smart00047
1074919002597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1074919002598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919002599 Coenzyme A binding pocket [chemical binding]; other site
1074919002600 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
1074919002601 Transcriptional regulator [Transcription]; Region: LytR; COG1316
1074919002602 Beta-lactamase; Region: Beta-lactamase; pfam00144
1074919002603 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1074919002604 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1074919002605 Subunit III/IV interface [polypeptide binding]; other site
1074919002606 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1074919002607 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1074919002608 D-pathway; other site
1074919002609 Putative ubiquinol binding site [chemical binding]; other site
1074919002610 Low-spin heme (heme b) binding site [chemical binding]; other site
1074919002611 Putative water exit pathway; other site
1074919002612 Binuclear center (heme o3/CuB) [ion binding]; other site
1074919002613 K-pathway; other site
1074919002614 Putative proton exit pathway; other site
1074919002615 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1074919002616 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1074919002617 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1074919002618 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
1074919002619 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1074919002620 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1074919002621 homodimer interface [polypeptide binding]; other site
1074919002622 NADP binding site [chemical binding]; other site
1074919002623 substrate binding site [chemical binding]; other site
1074919002624 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1074919002625 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1074919002626 ATP-grasp domain; Region: ATP-grasp; pfam02222
1074919002627 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1074919002628 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1074919002629 ATP binding site [chemical binding]; other site
1074919002630 active site
1074919002631 substrate binding site [chemical binding]; other site
1074919002632 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1074919002633 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1074919002634 putative active site [active]
1074919002635 catalytic triad [active]
1074919002636 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1074919002637 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1074919002638 dimerization interface [polypeptide binding]; other site
1074919002639 ATP binding site [chemical binding]; other site
1074919002640 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1074919002641 dimerization interface [polypeptide binding]; other site
1074919002642 ATP binding site [chemical binding]; other site
1074919002643 amidophosphoribosyltransferase; Provisional; Region: PRK07272
1074919002644 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1074919002645 tetramer interface [polypeptide binding]; other site
1074919002646 active site
1074919002647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919002648 active site
1074919002649 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1074919002650 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1074919002651 dimerization interface [polypeptide binding]; other site
1074919002652 putative ATP binding site [chemical binding]; other site
1074919002653 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1074919002654 active site
1074919002655 substrate binding site [chemical binding]; other site
1074919002656 cosubstrate binding site; other site
1074919002657 catalytic site [active]
1074919002658 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1074919002659 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1074919002660 purine monophosphate binding site [chemical binding]; other site
1074919002661 dimer interface [polypeptide binding]; other site
1074919002662 putative catalytic residues [active]
1074919002663 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1074919002664 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1074919002665 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1074919002666 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
1074919002667 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1074919002668 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1074919002669 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1074919002670 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919002671 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919002672 Walker A/P-loop; other site
1074919002673 ATP binding site [chemical binding]; other site
1074919002674 Q-loop/lid; other site
1074919002675 ABC transporter signature motif; other site
1074919002676 Walker B; other site
1074919002677 D-loop; other site
1074919002678 H-loop/switch region; other site
1074919002679 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
1074919002680 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919002681 Walker A/P-loop; other site
1074919002682 ATP binding site [chemical binding]; other site
1074919002683 Q-loop/lid; other site
1074919002684 ABC transporter signature motif; other site
1074919002685 Walker B; other site
1074919002686 D-loop; other site
1074919002687 H-loop/switch region; other site
1074919002688 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
1074919002689 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1074919002690 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1074919002691 putative RNA binding site [nucleotide binding]; other site
1074919002692 Methyltransferase domain; Region: Methyltransf_26; pfam13659
1074919002693 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1074919002694 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
1074919002695 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1074919002696 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1074919002697 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1074919002698 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1074919002699 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1074919002700 TrkA-N domain; Region: TrkA_N; pfam02254
1074919002701 TrkA-C domain; Region: TrkA_C; pfam02080
1074919002702 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1074919002703 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1074919002704 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
1074919002705 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1074919002706 active site
1074919002707 catalytic residues [active]
1074919002708 metal binding site [ion binding]; metal-binding site
1074919002709 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1074919002710 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1074919002711 TPP-binding site [chemical binding]; other site
1074919002712 tetramer interface [polypeptide binding]; other site
1074919002713 heterodimer interface [polypeptide binding]; other site
1074919002714 phosphorylation loop region [posttranslational modification]
1074919002715 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1074919002716 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1074919002717 alpha subunit interface [polypeptide binding]; other site
1074919002718 TPP binding site [chemical binding]; other site
1074919002719 heterodimer interface [polypeptide binding]; other site
1074919002720 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1074919002721 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1074919002722 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1074919002723 E3 interaction surface; other site
1074919002724 lipoyl attachment site [posttranslational modification]; other site
1074919002725 e3 binding domain; Region: E3_binding; pfam02817
1074919002726 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1074919002727 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1074919002728 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1074919002729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919002730 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1074919002731 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074919002732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919002733 non-specific DNA binding site [nucleotide binding]; other site
1074919002734 salt bridge; other site
1074919002735 sequence-specific DNA binding site [nucleotide binding]; other site
1074919002736 Cupin domain; Region: Cupin_2; pfam07883
1074919002737 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1074919002738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919002739 Walker A/P-loop; other site
1074919002740 ATP binding site [chemical binding]; other site
1074919002741 Q-loop/lid; other site
1074919002742 ABC transporter signature motif; other site
1074919002743 Walker B; other site
1074919002744 D-loop; other site
1074919002745 H-loop/switch region; other site
1074919002746 TOBE domain; Region: TOBE_2; pfam08402
1074919002747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1074919002748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002749 putative PBP binding loops; other site
1074919002750 dimer interface [polypeptide binding]; other site
1074919002751 ABC-ATPase subunit interface; other site
1074919002752 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1074919002753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919002754 dimer interface [polypeptide binding]; other site
1074919002755 conserved gate region; other site
1074919002756 putative PBP binding loops; other site
1074919002757 ABC-ATPase subunit interface; other site
1074919002758 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1074919002759 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
1074919002760 manganese transport protein MntH; Reviewed; Region: PRK00701
1074919002761 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1074919002762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1074919002763 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1074919002764 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1074919002765 active site
1074919002766 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1074919002767 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1074919002768 G1 box; other site
1074919002769 putative GEF interaction site [polypeptide binding]; other site
1074919002770 GTP/Mg2+ binding site [chemical binding]; other site
1074919002771 Switch I region; other site
1074919002772 G2 box; other site
1074919002773 G3 box; other site
1074919002774 Switch II region; other site
1074919002775 G4 box; other site
1074919002776 G5 box; other site
1074919002777 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1074919002778 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710
1074919002779 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1074919002780 pyruvate carboxylase; Reviewed; Region: PRK12999
1074919002781 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919002782 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1074919002783 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1074919002784 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1074919002785 active site
1074919002786 catalytic residues [active]
1074919002787 metal binding site [ion binding]; metal-binding site
1074919002788 homodimer binding site [polypeptide binding]; other site
1074919002789 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1074919002790 carboxyltransferase (CT) interaction site; other site
1074919002791 biotinylation site [posttranslational modification]; other site
1074919002792 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1074919002793 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1074919002794 protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1074919002795 UbiA prenyltransferase family; Region: UbiA; pfam01040
1074919002796 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504
1074919002797 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1074919002798 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1074919002799 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919002800 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1074919002801 putative active site [active]
1074919002802 catalytic site [active]
1074919002803 putative metal binding site [ion binding]; other site
1074919002804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919002805 S-adenosylmethionine binding site [chemical binding]; other site
1074919002806 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1074919002807 active site
1074919002808 (T/H)XGH motif; other site
1074919002809 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
1074919002810 hypothetical protein; Provisional; Region: PRK13670
1074919002811 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1074919002812 heme uptake protein IsdB; Region: IsdB; TIGR03657
1074919002813 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919002814 NEAr Transporter domain; Region: NEAT; smart00725
1074919002815 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1074919002816 heme-binding site [chemical binding]; other site
1074919002817 Protein of unknown function (DUF1675); Region: DUF1675; pfam07897
1074919002818 Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1074919002819 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
1074919002820 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1074919002821 heme-binding site [chemical binding]; other site
1074919002822 heme uptake protein IsdC; Region: IsdC; TIGR03656
1074919002823 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1074919002824 heme-binding site [chemical binding]; other site
1074919002825 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
1074919002826 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074919002827 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1074919002828 intersubunit interface [polypeptide binding]; other site
1074919002829 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919002830 ABC-ATPase subunit interface; other site
1074919002831 dimer interface [polypeptide binding]; other site
1074919002832 putative PBP binding regions; other site
1074919002833 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1074919002834 active site
1074919002835 catalytic site [active]
1074919002836 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1074919002837 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1074919002838 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1074919002839 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1074919002840 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1074919002841 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1074919002842 dimer interface [polypeptide binding]; other site
1074919002843 motif 1; other site
1074919002844 active site
1074919002845 motif 2; other site
1074919002846 motif 3; other site
1074919002847 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1074919002848 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1074919002849 putative tRNA-binding site [nucleotide binding]; other site
1074919002850 B3/4 domain; Region: B3_4; pfam03483
1074919002851 tRNA synthetase B5 domain; Region: B5; smart00874
1074919002852 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769
1074919002853 dimer interface [polypeptide binding]; other site
1074919002854 motif 1; other site
1074919002855 motif 3; other site
1074919002856 motif 2; other site
1074919002857 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1074919002858 ribonuclease HIII; Provisional; Region: PRK00996
1074919002859 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1074919002860 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1074919002861 RNA/DNA hybrid binding site [nucleotide binding]; other site
1074919002862 active site
1074919002863 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1074919002864 hypothetical protein; Provisional; Region: PRK08609
1074919002865 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1074919002866 active site
1074919002867 primer binding site [nucleotide binding]; other site
1074919002868 NTP binding site [chemical binding]; other site
1074919002869 metal binding triad [ion binding]; metal-binding site
1074919002870 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1074919002871 active site
1074919002872 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1074919002873 MutS domain III; Region: MutS_III; pfam05192
1074919002874 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1074919002875 Walker A/P-loop; other site
1074919002876 ATP binding site [chemical binding]; other site
1074919002877 Q-loop/lid; other site
1074919002878 ABC transporter signature motif; other site
1074919002879 Walker B; other site
1074919002880 D-loop; other site
1074919002881 H-loop/switch region; other site
1074919002882 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
1074919002883 Smr domain; Region: Smr; pfam01713
1074919002884 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1074919002885 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1074919002886 GIY-YIG motif/motif A; other site
1074919002887 active site
1074919002888 catalytic site [active]
1074919002889 putative DNA binding site [nucleotide binding]; other site
1074919002890 metal binding site [ion binding]; metal-binding site
1074919002891 UvrB/uvrC motif; Region: UVR; pfam02151
1074919002892 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1074919002893 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1074919002894 putative Iron-sulfur protein interface [polypeptide binding]; other site
1074919002895 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1074919002896 proximal heme binding site [chemical binding]; other site
1074919002897 distal heme binding site [chemical binding]; other site
1074919002898 putative dimer interface [polypeptide binding]; other site
1074919002899 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1074919002900 L-aspartate oxidase; Provisional; Region: PRK06175
1074919002901 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1074919002902 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1074919002903 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1074919002904 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1074919002905 glutamate racemase; Provisional; Region: PRK00865
1074919002906 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1074919002907 active site
1074919002908 dimerization interface [polypeptide binding]; other site
1074919002909 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1074919002910 active site
1074919002911 metal binding site [ion binding]; metal-binding site
1074919002912 homotetramer interface [polypeptide binding]; other site
1074919002913 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
1074919002914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919002915 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
1074919002916 Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919002917 beta-channel forming cytolysin; Region: hlyII; TIGR01002
1074919002918 superantigen-like protein; Reviewed; Region: PRK13350
1074919002919 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919002920 superantigen-like protein; Reviewed; Region: PRK13349
1074919002921 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919002922 superantigen-like protein; Reviewed; Region: PRK13043
1074919002923 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919002924 ornithine carbamoyltransferase; Provisional; Region: PRK04284
1074919002925 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1074919002926 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1074919002927 carbamate kinase; Reviewed; Region: PRK12686
1074919002928 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1074919002929 putative substrate binding site [chemical binding]; other site
1074919002930 nucleotide binding site [chemical binding]; other site
1074919002931 nucleotide binding site [chemical binding]; other site
1074919002932 homodimer interface [polypeptide binding]; other site
1074919002933 Predicted membrane protein [Function unknown]; Region: COG1288
1074919002934 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1074919002935 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1074919002936 gating phenylalanine in ion channel; other site
1074919002937 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1074919002938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919002939 motif II; other site
1074919002940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1074919002941 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1074919002942 MraW methylase family; Region: Methyltransf_5; pfam01795
1074919002943 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1074919002944 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1074919002945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1074919002946 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1074919002947 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1074919002948 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1074919002949 Mg++ binding site [ion binding]; other site
1074919002950 putative catalytic motif [active]
1074919002951 putative substrate binding site [chemical binding]; other site
1074919002952 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1074919002953 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1074919002954 NAD binding site [chemical binding]; other site
1074919002955 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919002956 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919002957 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1074919002958 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1074919002959 Cell division protein FtsQ; Region: FtsQ; pfam03799
1074919002960 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1074919002961 Cell division protein FtsA; Region: FtsA; smart00842
1074919002962 Cell division protein FtsA; Region: FtsA; pfam14450
1074919002963 cell division protein FtsZ; Validated; Region: PRK09330
1074919002964 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1074919002965 nucleotide binding site [chemical binding]; other site
1074919002966 SulA interaction site; other site
1074919002967 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1074919002968 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1074919002969 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919002970 catalytic residue [active]
1074919002971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1074919002972 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1074919002973 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919002974 RNA binding surface [nucleotide binding]; other site
1074919002975 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1074919002976 DivIVA protein; Region: DivIVA; pfam05103
1074919002977 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1074919002978 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1074919002979 active site
1074919002980 HIGH motif; other site
1074919002981 KMSKS motif; other site
1074919002982 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1074919002983 tRNA binding surface [nucleotide binding]; other site
1074919002984 anticodon binding site; other site
1074919002985 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1074919002986 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1074919002987 lipoprotein signal peptidase; Provisional; Region: PRK14787
1074919002988 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1074919002989 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919002990 RNA binding surface [nucleotide binding]; other site
1074919002991 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1074919002992 active site
1074919002993 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919002994 active site
1074919002995 uracil transporter; Provisional; Region: PRK10720
1074919002996 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1074919002997 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1074919002998 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1074919002999 dihydroorotase; Validated; Region: pyrC; PRK09357
1074919003000 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1074919003001 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1074919003002 active site
1074919003003 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1074919003004 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1074919003005 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1074919003006 catalytic site [active]
1074919003007 subunit interface [polypeptide binding]; other site
1074919003008 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1074919003009 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919003010 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1074919003011 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1074919003012 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919003013 ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074919003014 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1074919003015 IMP binding site; other site
1074919003016 dimer interface [polypeptide binding]; other site
1074919003017 interdomain contacts; other site
1074919003018 partial ornithine binding site; other site
1074919003019 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1074919003020 active site
1074919003021 dimer interface [polypeptide binding]; other site
1074919003022 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919003023 active site
1074919003024 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1074919003025 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137
1074919003026 Domain of unknown function (DUF814); Region: DUF814; pfam05670
1074919003027 Guanylate kinase; Region: Guanylate_kin; pfam00625
1074919003028 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1074919003029 catalytic site [active]
1074919003030 G-X2-G-X-G-K; other site
1074919003031 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1074919003032 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
1074919003033 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
1074919003034 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1074919003035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919003036 ATP binding site [chemical binding]; other site
1074919003037 putative Mg++ binding site [ion binding]; other site
1074919003038 helicase superfamily c-terminal domain; Region: HELICc; smart00490
1074919003039 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1074919003040 active site
1074919003041 catalytic residues [active]
1074919003042 metal binding site [ion binding]; metal-binding site
1074919003043 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1074919003044 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1074919003045 putative active site [active]
1074919003046 substrate binding site [chemical binding]; other site
1074919003047 putative cosubstrate binding site; other site
1074919003048 catalytic site [active]
1074919003049 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1074919003050 substrate binding site [chemical binding]; other site
1074919003051 16S rRNA methyltransferase B; Provisional; Region: PRK14902
1074919003052 NusB family; Region: NusB; pfam01029
1074919003053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919003054 S-adenosylmethionine binding site [chemical binding]; other site
1074919003055 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
1074919003056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919003057 FeS/SAM binding site; other site
1074919003058 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1074919003059 active site
1074919003060 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1074919003061 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1074919003062 active site
1074919003063 ATP binding site [chemical binding]; other site
1074919003064 substrate binding site [chemical binding]; other site
1074919003065 activation loop (A-loop); other site
1074919003066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1074919003067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074919003068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074919003069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1074919003070 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1074919003071 RNA binding site [nucleotide binding]; other site
1074919003072 Predicted GTPases [General function prediction only]; Region: COG1162
1074919003073 homodimer interface [polypeptide binding]; other site
1074919003074 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1074919003075 GTPase/Zn-binding domain interface [polypeptide binding]; other site
1074919003076 GTP/Mg2+ binding site [chemical binding]; other site
1074919003077 G4 box; other site
1074919003078 G5 box; other site
1074919003079 G1 box; other site
1074919003080 Switch I region; other site
1074919003081 G2 box; other site
1074919003082 G3 box; other site
1074919003083 Switch II region; other site
1074919003084 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1074919003085 substrate binding site [chemical binding]; other site
1074919003086 hexamer interface [polypeptide binding]; other site
1074919003087 metal binding site [ion binding]; metal-binding site
1074919003088 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1074919003089 Thiamine pyrophosphokinase; Region: TPK; cd07995
1074919003090 active site
1074919003091 dimerization interface [polypeptide binding]; other site
1074919003092 thiamine binding site [chemical binding]; other site
1074919003093 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
1074919003094 DAK2 domain; Region: Dak2; pfam02734
1074919003095 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
1074919003096 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1074919003097 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1074919003098 generic binding surface II; other site
1074919003099 ssDNA binding site; other site
1074919003100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919003101 ATP binding site [chemical binding]; other site
1074919003102 putative Mg++ binding site [ion binding]; other site
1074919003103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919003104 nucleotide binding region [chemical binding]; other site
1074919003105 ATP-binding site [chemical binding]; other site
1074919003106 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1074919003107 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1074919003108 active site 2 [active]
1074919003109 active site 1 [active]
1074919003110 putative phosphate acyltransferase; Provisional; Region: PRK05331
1074919003111 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1074919003112 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1074919003113 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1074919003114 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1074919003115 NAD(P) binding site [chemical binding]; other site
1074919003116 homotetramer interface [polypeptide binding]; other site
1074919003117 homodimer interface [polypeptide binding]; other site
1074919003118 active site
1074919003119 ribonuclease III; Reviewed; Region: rnc; PRK00102
1074919003120 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1074919003121 dimerization interface [polypeptide binding]; other site
1074919003122 active site
1074919003123 metal binding site [ion binding]; metal-binding site
1074919003124 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1074919003125 dsRNA binding site [nucleotide binding]; other site
1074919003126 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1074919003127 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1074919003128 Walker A/P-loop; other site
1074919003129 ATP binding site [chemical binding]; other site
1074919003130 Q-loop/lid; other site
1074919003131 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1074919003132 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1074919003133 ABC transporter signature motif; other site
1074919003134 Walker B; other site
1074919003135 D-loop; other site
1074919003136 H-loop/switch region; other site
1074919003137 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1074919003138 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1074919003139 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1074919003140 P loop; other site
1074919003141 GTP binding site [chemical binding]; other site
1074919003142 signal recognition particle protein; Provisional; Region: PRK10867
1074919003143 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1074919003144 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1074919003145 P loop; other site
1074919003146 GTP binding site [chemical binding]; other site
1074919003147 Signal peptide binding domain; Region: SRP_SPB; pfam02978
1074919003148 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1074919003149 RimM N-terminal domain; Region: RimM; pfam01782
1074919003150 PRC-barrel domain; Region: PRC; pfam05239
1074919003151 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1074919003152 Predicted membrane protein [Function unknown]; Region: COG4485
1074919003153 GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1074919003154 Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1074919003155 GTP/Mg2+ binding site [chemical binding]; other site
1074919003156 G4 box; other site
1074919003157 G5 box; other site
1074919003158 G1 box; other site
1074919003159 Switch I region; other site
1074919003160 G2 box; other site
1074919003161 G3 box; other site
1074919003162 Switch II region; other site
1074919003163 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1074919003164 RNA/DNA hybrid binding site [nucleotide binding]; other site
1074919003165 active site
1074919003166 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1074919003167 ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1074919003168 CoA-ligase; Region: Ligase_CoA; pfam00549
1074919003169 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1074919003170 CoA binding domain; Region: CoA_binding; pfam02629
1074919003171 CoA-ligase; Region: Ligase_CoA; pfam00549
1074919003172 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1074919003173 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919003174 CHAP domain; Region: CHAP; pfam05257
1074919003175 FemAB family; Region: FemAB; pfam02388
1074919003176 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1074919003177 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1074919003178 DNA topoisomerase I; Validated; Region: PRK05582
1074919003179 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1074919003180 active site
1074919003181 interdomain interaction site; other site
1074919003182 putative metal-binding site [ion binding]; other site
1074919003183 nucleotide binding site [chemical binding]; other site
1074919003184 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1074919003185 domain I; other site
1074919003186 DNA binding groove [nucleotide binding]
1074919003187 phosphate binding site [ion binding]; other site
1074919003188 domain II; other site
1074919003189 domain III; other site
1074919003190 nucleotide binding site [chemical binding]; other site
1074919003191 catalytic site [active]
1074919003192 domain IV; other site
1074919003193 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1074919003194 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1074919003195 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1074919003196 Glucose inhibited division protein A; Region: GIDA; pfam01134
1074919003197 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919003198 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919003199 active site
1074919003200 DNA binding site [nucleotide binding]
1074919003201 Int/Topo IB signature motif; other site
1074919003202 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1074919003203 active site
1074919003204 HslU subunit interaction site [polypeptide binding]; other site
1074919003205 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1074919003206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919003207 Walker A motif; other site
1074919003208 ATP binding site [chemical binding]; other site
1074919003209 Walker B motif; other site
1074919003210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919003211 Walker B motif; other site
1074919003212 arginine finger; other site
1074919003213 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1074919003214 transcriptional repressor CodY; Validated; Region: PRK04158
1074919003215 CodY GAF-like domain; Region: CodY; pfam06018
1074919003216 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1074919003217 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1074919003218 rRNA interaction site [nucleotide binding]; other site
1074919003219 S8 interaction site; other site
1074919003220 putative laminin-1 binding site; other site
1074919003221 elongation factor Ts; Provisional; Region: tsf; PRK09377
1074919003222 UBA/TS-N domain; Region: UBA; pfam00627
1074919003223 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1074919003224 putative nucleotide binding site [chemical binding]; other site
1074919003225 uridine monophosphate binding site [chemical binding]; other site
1074919003226 homohexameric interface [polypeptide binding]; other site
1074919003227 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1074919003228 hinge region; other site
1074919003229 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
1074919003230 active site
1074919003231 dimer interface [polypeptide binding]; other site
1074919003232 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1074919003233 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1074919003234 RIP metalloprotease RseP; Region: TIGR00054
1074919003235 active site
1074919003236 putative substrate binding region [chemical binding]; other site
1074919003237 prolyl-tRNA synthetase; Provisional; Region: PRK09194
1074919003238 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1074919003239 dimer interface [polypeptide binding]; other site
1074919003240 motif 1; other site
1074919003241 active site
1074919003242 motif 2; other site
1074919003243 motif 3; other site
1074919003244 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1074919003245 anticodon binding site; other site
1074919003246 DNA polymerase III PolC; Validated; Region: polC; PRK00448
1074919003247 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480
1074919003248 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490
1074919003249 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1074919003250 generic binding surface II; other site
1074919003251 generic binding surface I; other site
1074919003252 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1074919003253 active site
1074919003254 putative PHP Thumb interface [polypeptide binding]; other site
1074919003255 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1074919003256 Helix-hairpin-helix motif; Region: HHH_6; pfam14579
1074919003257 ribosome maturation protein RimP; Reviewed; Region: PRK00092
1074919003258 Sm and related proteins; Region: Sm_like; cl00259
1074919003259 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1074919003260 putative oligomer interface [polypeptide binding]; other site
1074919003261 putative RNA binding site [nucleotide binding]; other site
1074919003262 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1074919003263 NusA N-terminal domain; Region: NusA_N; pfam08529
1074919003264 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1074919003265 RNA binding site [nucleotide binding]; other site
1074919003266 homodimer interface [polypeptide binding]; other site
1074919003267 NusA-like KH domain; Region: KH_5; pfam13184
1074919003268 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1074919003269 G-X-X-G motif; other site
1074919003270 translation initiation factor IF-2; Validated; Region: infB; PRK05306
1074919003271 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1074919003272 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1074919003273 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1074919003274 G1 box; other site
1074919003275 putative GEF interaction site [polypeptide binding]; other site
1074919003276 GTP/Mg2+ binding site [chemical binding]; other site
1074919003277 Switch I region; other site
1074919003278 G2 box; other site
1074919003279 G3 box; other site
1074919003280 Switch II region; other site
1074919003281 G4 box; other site
1074919003282 G5 box; other site
1074919003283 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1074919003284 Translation-initiation factor 2; Region: IF-2; pfam11987
1074919003285 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1074919003286 tRNA pseudouridine synthase B; Provisional; Region: PRK14123
1074919003287 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1074919003288 RNA binding site [nucleotide binding]; other site
1074919003289 active site
1074919003290 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1074919003291 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1074919003292 active site
1074919003293 Riboflavin kinase; Region: Flavokinase; smart00904
1074919003294 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1074919003295 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1074919003296 RNase E interface [polypeptide binding]; other site
1074919003297 trimer interface [polypeptide binding]; other site
1074919003298 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1074919003299 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1074919003300 RNase E interface [polypeptide binding]; other site
1074919003301 trimer interface [polypeptide binding]; other site
1074919003302 active site
1074919003303 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1074919003304 putative nucleic acid binding region [nucleotide binding]; other site
1074919003305 G-X-X-G motif; other site
1074919003306 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1074919003307 RNA binding site [nucleotide binding]; other site
1074919003308 domain interface; other site
1074919003309 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1074919003310 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1074919003311 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1074919003312 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1074919003313 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1074919003314 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074919003315 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1074919003316 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1074919003317 Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1074919003318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1074919003319 DNA-binding site [nucleotide binding]; DNA binding site
1074919003320 UTRA domain; Region: UTRA; pfam07702
1074919003321 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1074919003322 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1074919003323 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1074919003324 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1074919003325 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1074919003326 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1074919003327 classical (c) SDRs; Region: SDR_c; cd05233
1074919003328 NAD(P) binding site [chemical binding]; other site
1074919003329 active site
1074919003330 ACT domain; Region: ACT; pfam01842
1074919003331 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1074919003332 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1074919003333 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1074919003334 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1074919003335 putative MPT binding site; other site
1074919003336 recombinase A; Provisional; Region: recA; PRK09354
1074919003337 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1074919003338 hexamer interface [polypeptide binding]; other site
1074919003339 Walker A motif; other site
1074919003340 ATP binding site [chemical binding]; other site
1074919003341 Walker B motif; other site
1074919003342 phosphodiesterase; Provisional; Region: PRK12704
1074919003343 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919003344 Zn2+ binding site [ion binding]; other site
1074919003345 Mg2+ binding site [ion binding]; other site
1074919003346 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1074919003347 putative active site [active]
1074919003348 metal binding site [ion binding]; metal-binding site
1074919003349 homodimer binding site [polypeptide binding]; other site
1074919003350 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1074919003351 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
1074919003352 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1074919003353 dimer interface [polypeptide binding]; other site
1074919003354 PYR/PP interface [polypeptide binding]; other site
1074919003355 TPP binding site [chemical binding]; other site
1074919003356 substrate binding site [chemical binding]; other site
1074919003357 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1074919003358 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1074919003359 TPP-binding site [chemical binding]; other site
1074919003360 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1074919003361 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1074919003362 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1074919003363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919003364 FeS/SAM binding site; other site
1074919003365 TRAM domain; Region: TRAM; pfam01938
1074919003366 Predicted membrane protein [Function unknown]; Region: COG4732
1074919003367 DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1074919003368 MutS domain I; Region: MutS_I; pfam01624
1074919003369 MutS domain II; Region: MutS_II; pfam05188
1074919003370 MutS domain III; Region: MutS_III; pfam05192
1074919003371 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1074919003372 Walker A/P-loop; other site
1074919003373 ATP binding site [chemical binding]; other site
1074919003374 Q-loop/lid; other site
1074919003375 ABC transporter signature motif; other site
1074919003376 Walker B; other site
1074919003377 D-loop; other site
1074919003378 H-loop/switch region; other site
1074919003379 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1074919003380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919003381 ATP binding site [chemical binding]; other site
1074919003382 Mg2+ binding site [ion binding]; other site
1074919003383 G-X-G motif; other site
1074919003384 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1074919003385 ATP binding site [chemical binding]; other site
1074919003386 MutL C terminal dimerization domain; Region: MutL_C; pfam08676
1074919003387 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
1074919003388 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1074919003389 amphipathic channel; other site
1074919003390 Asn-Pro-Ala signature motifs; other site
1074919003391 glycerol kinase; Provisional; Region: glpK; PRK00047
1074919003392 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1074919003393 N- and C-terminal domain interface [polypeptide binding]; other site
1074919003394 active site
1074919003395 MgATP binding site [chemical binding]; other site
1074919003396 catalytic site [active]
1074919003397 metal binding site [ion binding]; metal-binding site
1074919003398 glycerol binding site [chemical binding]; other site
1074919003399 homotetramer interface [polypeptide binding]; other site
1074919003400 homodimer interface [polypeptide binding]; other site
1074919003401 FBP binding site [chemical binding]; other site
1074919003402 protein IIAGlc interface [polypeptide binding]; other site
1074919003403 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1074919003404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1074919003405 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1074919003406 Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1074919003407 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1074919003408 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1074919003409 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1074919003410 catalytic residues [active]
1074919003411 dimer interface [polypeptide binding]; other site
1074919003412 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1074919003413 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1074919003414 HflX GTPase family; Region: HflX; cd01878
1074919003415 G1 box; other site
1074919003416 GTP/Mg2+ binding site [chemical binding]; other site
1074919003417 Switch I region; other site
1074919003418 G2 box; other site
1074919003419 G3 box; other site
1074919003420 Switch II region; other site
1074919003421 G4 box; other site
1074919003422 G5 box; other site
1074919003423 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1074919003424 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1074919003425 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1074919003426 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1074919003427 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1074919003428 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1074919003429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919003430 catalytic residue [active]
1074919003431 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1074919003432 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1074919003433 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1074919003434 putative active site [active]
1074919003435 catalytic site [active]
1074919003436 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1074919003437 putative active site [active]
1074919003438 catalytic site [active]
1074919003439 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074919003440 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919003441 Walker A/P-loop; other site
1074919003442 ATP binding site [chemical binding]; other site
1074919003443 Q-loop/lid; other site
1074919003444 ABC transporter signature motif; other site
1074919003445 Walker B; other site
1074919003446 D-loop; other site
1074919003447 H-loop/switch region; other site
1074919003448 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1074919003449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074919003450 Histidine kinase; Region: HisKA_3; pfam07730
1074919003451 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1074919003452 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074919003453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919003454 active site
1074919003455 phosphorylation site [posttranslational modification]
1074919003456 intermolecular recognition site; other site
1074919003457 dimerization interface [polypeptide binding]; other site
1074919003458 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074919003459 DNA binding residues [nucleotide binding]
1074919003460 dimerization interface [polypeptide binding]; other site
1074919003461 Staphylococcal nuclease homologues; Region: SNc; smart00318
1074919003462 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1074919003463 Catalytic site; other site
1074919003464 AAA domain; Region: AAA_11; pfam13086
1074919003465 aspartate kinase; Reviewed; Region: PRK09034
1074919003466 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1074919003467 putative catalytic residues [active]
1074919003468 putative nucleotide binding site [chemical binding]; other site
1074919003469 putative aspartate binding site [chemical binding]; other site
1074919003470 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1074919003471 allosteric regulatory residue; other site
1074919003472 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1074919003473 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1074919003474 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1074919003475 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1074919003476 threonine synthase; Reviewed; Region: PRK06721
1074919003477 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1074919003478 homodimer interface [polypeptide binding]; other site
1074919003479 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919003480 catalytic residue [active]
1074919003481 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
1074919003482 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1074919003483 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1074919003484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919003485 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1074919003486 active site
1074919003487 motif I; other site
1074919003488 motif II; other site
1074919003489 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1074919003490 lysine transporter; Provisional; Region: PRK10836
1074919003491 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1074919003492 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1074919003493 tetramer interface [polypeptide binding]; other site
1074919003494 heme binding pocket [chemical binding]; other site
1074919003495 NADPH binding site [chemical binding]; other site
1074919003496 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1074919003497 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1074919003498 active site
1074919003499 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1074919003500 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1074919003501 LexA repressor; Validated; Region: PRK00215
1074919003502 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1074919003503 putative DNA binding site [nucleotide binding]; other site
1074919003504 putative Zn2+ binding site [ion binding]; other site
1074919003505 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1074919003506 Catalytic site [active]
1074919003507 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1074919003508 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1074919003509 TPP-binding site [chemical binding]; other site
1074919003510 dimer interface [polypeptide binding]; other site
1074919003511 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1074919003512 PYR/PP interface [polypeptide binding]; other site
1074919003513 dimer interface [polypeptide binding]; other site
1074919003514 TPP binding site [chemical binding]; other site
1074919003515 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1074919003516 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
1074919003517 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1074919003518 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1074919003519 active site
1074919003520 metal binding site [ion binding]; metal-binding site
1074919003521 DNA binding site [nucleotide binding]
1074919003522 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1074919003523 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1074919003524 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1074919003525 Walker A/P-loop; other site
1074919003526 ATP binding site [chemical binding]; other site
1074919003527 Q-loop/lid; other site
1074919003528 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1074919003529 Q-loop/lid; other site
1074919003530 ABC transporter signature motif; other site
1074919003531 Walker B; other site
1074919003532 D-loop; other site
1074919003533 H-loop/switch region; other site
1074919003534 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1074919003535 aconitate hydratase; Validated; Region: PRK09277
1074919003536 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1074919003537 substrate binding site [chemical binding]; other site
1074919003538 ligand binding site [chemical binding]; other site
1074919003539 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1074919003540 substrate binding site [chemical binding]; other site
1074919003541 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1074919003542 active site
1074919003543 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1074919003544 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1074919003545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919003546 ATP binding site [chemical binding]; other site
1074919003547 Mg2+ binding site [ion binding]; other site
1074919003548 G-X-G motif; other site
1074919003549 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1074919003550 anchoring element; other site
1074919003551 dimer interface [polypeptide binding]; other site
1074919003552 ATP binding site [chemical binding]; other site
1074919003553 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1074919003554 active site
1074919003555 putative metal-binding site [ion binding]; other site
1074919003556 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1074919003557 DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1074919003558 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1074919003559 CAP-like domain; other site
1074919003560 active site
1074919003561 primary dimer interface [polypeptide binding]; other site
1074919003562 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1074919003563 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1074919003564 amino acid carrier protein; Region: agcS; TIGR00835
1074919003565 CAT RNA binding domain; Region: CAT_RBD; smart01061
1074919003566 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919003567 PRD domain; Region: PRD; pfam00874
1074919003568 PRD domain; Region: PRD; pfam00874
1074919003569 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1074919003570 Predicted integral membrane protein [Function unknown]; Region: COG0392
1074919003571 Uncharacterized conserved protein [Function unknown]; Region: COG2898
1074919003572 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1074919003573 methionine sulfoxide reductase A; Provisional; Region: PRK14054
1074919003574 Transcriptional regulator [Transcription]; Region: LytR; COG1316
1074919003575 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1074919003576 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1074919003577 active site
1074919003578 DNA binding site [nucleotide binding]
1074919003579 prephenate dehydrogenase; Validated; Region: PRK06545
1074919003580 prephenate dehydrogenase; Validated; Region: PRK08507
1074919003581 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1074919003582 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1074919003583 putative oligomer interface [polypeptide binding]; other site
1074919003584 putative active site [active]
1074919003585 metal binding site [ion binding]; metal-binding site
1074919003586 anthranilate synthase component I; Provisional; Region: PRK13567
1074919003587 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1074919003588 chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1074919003589 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1074919003590 glutamine binding [chemical binding]; other site
1074919003591 catalytic triad [active]
1074919003592 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1074919003593 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1074919003594 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1074919003595 active site
1074919003596 ribulose/triose binding site [chemical binding]; other site
1074919003597 phosphate binding site [ion binding]; other site
1074919003598 substrate (anthranilate) binding pocket [chemical binding]; other site
1074919003599 product (indole) binding pocket [chemical binding]; other site
1074919003600 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1074919003601 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919003602 catalytic residue [active]
1074919003603 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1074919003604 substrate binding site [chemical binding]; other site
1074919003605 active site
1074919003606 catalytic residues [active]
1074919003607 heterodimer interface [polypeptide binding]; other site
1074919003608 FemAB family; Region: FemAB; pfam02388
1074919003609 FemAB family; Region: FemAB; pfam02388
1074919003610 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1074919003611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919003612 active site
1074919003613 motif I; other site
1074919003614 motif II; other site
1074919003615 SWIM zinc finger; Region: SWIM; pfam04434
1074919003616 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919003617 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1074919003618 Walker A/P-loop; other site
1074919003619 ATP binding site [chemical binding]; other site
1074919003620 Q-loop/lid; other site
1074919003621 ABC transporter signature motif; other site
1074919003622 Walker B; other site
1074919003623 D-loop; other site
1074919003624 H-loop/switch region; other site
1074919003625 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1074919003626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919003627 Walker A/P-loop; other site
1074919003628 ATP binding site [chemical binding]; other site
1074919003629 Q-loop/lid; other site
1074919003630 ABC transporter signature motif; other site
1074919003631 Walker B; other site
1074919003632 D-loop; other site
1074919003633 H-loop/switch region; other site
1074919003634 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1074919003635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919003636 dimer interface [polypeptide binding]; other site
1074919003637 conserved gate region; other site
1074919003638 putative PBP binding loops; other site
1074919003639 ABC-ATPase subunit interface; other site
1074919003640 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919003641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919003642 dimer interface [polypeptide binding]; other site
1074919003643 conserved gate region; other site
1074919003644 putative PBP binding loops; other site
1074919003645 ABC-ATPase subunit interface; other site
1074919003646 oligoendopeptidase F; Region: pepF; TIGR00181
1074919003647 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1074919003648 active site
1074919003649 Zn binding site [ion binding]; other site
1074919003650 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1074919003651 PhoU domain; Region: PhoU; pfam01895
1074919003652 PhoU domain; Region: PhoU; pfam01895
1074919003653 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
1074919003654 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1074919003655 Walker A/P-loop; other site
1074919003656 ATP binding site [chemical binding]; other site
1074919003657 Q-loop/lid; other site
1074919003658 ABC transporter signature motif; other site
1074919003659 Walker B; other site
1074919003660 D-loop; other site
1074919003661 H-loop/switch region; other site
1074919003662 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1074919003663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919003664 dimer interface [polypeptide binding]; other site
1074919003665 conserved gate region; other site
1074919003666 putative PBP binding loops; other site
1074919003667 ABC-ATPase subunit interface; other site
1074919003668 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1074919003669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919003670 dimer interface [polypeptide binding]; other site
1074919003671 conserved gate region; other site
1074919003672 ABC-ATPase subunit interface; other site
1074919003673 phosphate binding protein; Region: ptsS_2; TIGR02136
1074919003674 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1074919003675 S1 domain; Region: S1_2; pfam13509
1074919003676 ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1074919003677 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919003678 ABC transporter; Region: ABC_tran_2; pfam12848
1074919003679 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919003680 aspartate kinase; Reviewed; Region: PRK06635
1074919003681 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1074919003682 putative nucleotide binding site [chemical binding]; other site
1074919003683 putative catalytic residues [active]
1074919003684 putative Mg ion binding site [ion binding]; other site
1074919003685 putative aspartate binding site [chemical binding]; other site
1074919003686 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
1074919003687 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
1074919003688 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1074919003689 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
1074919003690 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
1074919003691 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1074919003692 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1074919003693 dimer interface [polypeptide binding]; other site
1074919003694 active site
1074919003695 catalytic residue [active]
1074919003696 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1074919003697 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1074919003698 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1074919003699 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1074919003700 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1074919003701 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1074919003702 active site
1074919003703 trimer interface [polypeptide binding]; other site
1074919003704 substrate binding site [chemical binding]; other site
1074919003705 CoA binding site [chemical binding]; other site
1074919003706 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074919003707 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1074919003708 metal binding site [ion binding]; metal-binding site
1074919003709 dimer interface [polypeptide binding]; other site
1074919003710 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1074919003711 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1074919003712 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919003713 catalytic residue [active]
1074919003714 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1074919003715 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1074919003716 active site
1074919003717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919003718 substrate binding site [chemical binding]; other site
1074919003719 catalytic residues [active]
1074919003720 dimer interface [polypeptide binding]; other site
1074919003721 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
1074919003722 Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1074919003723 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
1074919003724 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1074919003725 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1074919003726 metal ion-dependent adhesion site (MIDAS); other site
1074919003727 MoxR-like ATPases [General function prediction only]; Region: COG0714
1074919003728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919003729 Walker A motif; other site
1074919003730 ATP binding site [chemical binding]; other site
1074919003731 Walker B motif; other site
1074919003732 arginine finger; other site
1074919003733 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1074919003734 active site
1074919003735 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1074919003736 active site
1074919003737 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1074919003738 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1074919003739 E3 interaction surface; other site
1074919003740 lipoyl attachment site [posttranslational modification]; other site
1074919003741 e3 binding domain; Region: E3_binding; pfam02817
1074919003742 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1074919003743 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1074919003744 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1074919003745 TPP-binding site [chemical binding]; other site
1074919003746 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
1074919003747 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1074919003748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919003749 HAMP domain; Region: HAMP; pfam00672
1074919003750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919003751 dimer interface [polypeptide binding]; other site
1074919003752 phosphorylation site [posttranslational modification]
1074919003753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919003754 ATP binding site [chemical binding]; other site
1074919003755 Mg2+ binding site [ion binding]; other site
1074919003756 G-X-G motif; other site
1074919003757 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919003758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919003759 active site
1074919003760 phosphorylation site [posttranslational modification]
1074919003761 intermolecular recognition site; other site
1074919003762 dimerization interface [polypeptide binding]; other site
1074919003763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919003764 DNA binding site [nucleotide binding]
1074919003765 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1074919003766 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1074919003767 active site
1074919003768 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1074919003769 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1074919003770 active site
1074919003771 homodimer interface [polypeptide binding]; other site
1074919003772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1074919003773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919003774 Coenzyme A binding pocket [chemical binding]; other site
1074919003775 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1074919003776 C-terminal peptidase (prc); Region: prc; TIGR00225
1074919003777 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1074919003778 protein binding site [polypeptide binding]; other site
1074919003779 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1074919003780 Catalytic dyad [active]
1074919003781 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1074919003782 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1074919003783 HPr interaction site; other site
1074919003784 glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074919003785 active site
1074919003786 phosphorylation site [posttranslational modification]
1074919003787 methionine sulfoxide reductase A; Provisional; Region: PRK13014
1074919003788 EDD domain protein, DegV family; Region: DegV; TIGR00762
1074919003789 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1074919003790 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1074919003791 folate binding site [chemical binding]; other site
1074919003792 NADP+ binding site [chemical binding]; other site
1074919003793 thymidylate synthase; Region: thym_sym; TIGR03284
1074919003794 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1074919003795 dimerization interface [polypeptide binding]; other site
1074919003796 active site
1074919003797 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1074919003798 Virulence factor; Region: Virulence_fact; pfam13769
1074919003799 HEAT repeats; Region: HEAT_2; pfam13646
1074919003800 HEAT repeat; Region: HEAT; pfam02985
1074919003801 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1074919003802 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919003803 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
1074919003804 GA module; Region: GA; smart00844
1074919003805 GA module; Region: GA; smart00844
1074919003806 GA module; Region: GA; smart00844
1074919003807 GA module; Region: GA; smart00844
1074919003808 GA module; Region: GA; smart00844
1074919003809 GA module; Region: GA; smart00844
1074919003810 GA module; Region: GA; smart00844
1074919003811 GA module; Region: GA; smart00844
1074919003812 GA module; Region: GA; smart00844
1074919003813 GA module; Region: GA; smart00844
1074919003814 GA module; Region: GA; smart00844
1074919003815 GA module; Region: GA; smart00844
1074919003816 GA module; Region: GA; smart00844
1074919003817 GA module; Region: GA; smart00844
1074919003818 GA module; Region: GA; smart00844
1074919003819 GA module; Region: GA; smart00844
1074919003820 GA module; Region: GA; smart00844
1074919003821 GA module; Region: GA; smart00844
1074919003822 GA module; Region: GA; smart00844
1074919003823 GA module; Region: GA; smart00844
1074919003824 GA module; Region: GA; smart00844
1074919003825 GA module; Region: GA; smart00844
1074919003826 GA module; Region: GA; smart00844
1074919003827 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
1074919003828 GA module; Region: GA; smart00844
1074919003829 GA module; Region: GA; smart00844
1074919003830 GA module; Region: GA; pfam01468
1074919003831 GA module; Region: GA; smart00844
1074919003832 GA module; Region: GA; smart00844
1074919003833 GA module; Region: GA; smart00844
1074919003834 GA module; Region: GA; smart00844
1074919003835 GA module; Region: GA; pfam01468
1074919003836 GA module; Region: GA; smart00844
1074919003837 GA module; Region: GA; smart00844
1074919003838 GA module; Region: GA; smart00844
1074919003839 GA module; Region: GA; smart00844
1074919003840 GA module; Region: GA; smart00844
1074919003841 GA module; Region: GA; smart00844
1074919003842 chromosome segregation protein; Provisional; Region: PRK02224
1074919003843 GA module; Region: GA; smart00844
1074919003844 GA module; Region: GA; smart00844
1074919003845 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1074919003846 GA module; Region: GA; pfam01468
1074919003847 GA module; Region: GA; smart00844
1074919003848 GA module; Region: GA; smart00844
1074919003849 GA module; Region: GA; smart00844
1074919003850 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919003851 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919003852 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1074919003853 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1074919003854 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1074919003855 C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1074919003856 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1074919003857 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1074919003858 tetramer interface [polypeptide binding]; other site
1074919003859 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919003860 catalytic residue [active]
1074919003861 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1074919003862 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1074919003863 hexamer interface [polypeptide binding]; other site
1074919003864 ligand binding site [chemical binding]; other site
1074919003865 putative active site [active]
1074919003866 NAD(P) binding site [chemical binding]; other site
1074919003867 5'-3' exonuclease; Region: 53EXOc; smart00475
1074919003868 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1074919003869 active site
1074919003870 metal binding site 1 [ion binding]; metal-binding site
1074919003871 putative 5' ssDNA interaction site; other site
1074919003872 metal binding site 3; metal-binding site
1074919003873 metal binding site 2 [ion binding]; metal-binding site
1074919003874 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1074919003875 putative DNA binding site [nucleotide binding]; other site
1074919003876 putative metal binding site [ion binding]; other site
1074919003877 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1074919003878 G1 box; other site
1074919003879 GTP/Mg2+ binding site [chemical binding]; other site
1074919003880 G2 box; other site
1074919003881 Switch I region; other site
1074919003882 G3 box; other site
1074919003883 Switch II region; other site
1074919003884 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1074919003885 G4 box; other site
1074919003886 Dynamin family; Region: Dynamin_N; pfam00350
1074919003887 G1 box; other site
1074919003888 GTP/Mg2+ binding site [chemical binding]; other site
1074919003889 G2 box; other site
1074919003890 Switch I region; other site
1074919003891 G3 box; other site
1074919003892 Switch II region; other site
1074919003893 G4 box; other site
1074919003894 G5 box; other site
1074919003895 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1074919003896 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1074919003897 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1074919003898 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1074919003899 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1074919003900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1074919003901 hypothetical protein; Provisional; Region: PRK13660
1074919003902 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1074919003903 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1074919003904 Transglycosylase; Region: Transgly; pfam00912
1074919003905 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1074919003906 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1074919003907 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1074919003908 minor groove reading motif; other site
1074919003909 helix-hairpin-helix signature motif; other site
1074919003910 substrate binding pocket [chemical binding]; other site
1074919003911 active site
1074919003912 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1074919003913 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1074919003914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
1074919003915 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1074919003916 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1074919003917 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1074919003918 putative dimer interface [polypeptide binding]; other site
1074919003919 putative anticodon binding site; other site
1074919003920 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1074919003921 homodimer interface [polypeptide binding]; other site
1074919003922 motif 1; other site
1074919003923 motif 2; other site
1074919003924 active site
1074919003925 motif 3; other site
1074919003926 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1074919003927 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1074919003928 active site
1074919003929 catalytic site [active]
1074919003930 substrate binding site [chemical binding]; other site
1074919003931 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1074919003932 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1074919003933 Biotin operon repressor [Transcription]; Region: BirA; COG1654
1074919003934 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1074919003935 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1074919003936 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1074919003937 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1074919003938 active site
1074919003939 NTP binding site [chemical binding]; other site
1074919003940 metal binding triad [ion binding]; metal-binding site
1074919003941 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1074919003942 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1074919003943 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1074919003944 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1074919003945 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1074919003946 Protein of unknown function (DUF1405); Region: DUF1405; cl01798
1074919003947 Uncharacterized conserved protein [Function unknown]; Region: COG5582
1074919003948 UPF0302 domain; Region: UPF0302; pfam08864
1074919003949 A short protein domain of unknown function; Region: IDEAL; smart00914
1074919003950 TPR repeat; Region: TPR_11; pfam13414
1074919003951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919003952 binding surface
1074919003953 TPR motif; other site
1074919003954 Tetratricopeptide repeat; Region: TPR_12; pfam13424
1074919003955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919003956 TPR motif; other site
1074919003957 binding surface
1074919003958 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1074919003959 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1074919003960 hinge; other site
1074919003961 active site
1074919003962 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1074919003963 active site
1074919003964 NAD binding site [chemical binding]; other site
1074919003965 metal binding site [ion binding]; metal-binding site
1074919003966 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1074919003967 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1074919003968 Tetramer interface [polypeptide binding]; other site
1074919003969 active site
1074919003970 FMN-binding site [chemical binding]; other site
1074919003971 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1074919003972 active site
1074919003973 multimer interface [polypeptide binding]; other site
1074919003974 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1074919003975 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1074919003976 substrate binding pocket [chemical binding]; other site
1074919003977 chain length determination region; other site
1074919003978 substrate-Mg2+ binding site; other site
1074919003979 catalytic residues [active]
1074919003980 aspartate-rich region 1; other site
1074919003981 active site lid residues [active]
1074919003982 aspartate-rich region 2; other site
1074919003983 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1074919003984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919003985 S-adenosylmethionine binding site [chemical binding]; other site
1074919003986 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1074919003987 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1074919003988 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1074919003989 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1074919003990 GTP-binding protein Der; Reviewed; Region: PRK00093
1074919003991 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1074919003992 G1 box; other site
1074919003993 GTP/Mg2+ binding site [chemical binding]; other site
1074919003994 Switch I region; other site
1074919003995 G2 box; other site
1074919003996 Switch II region; other site
1074919003997 G3 box; other site
1074919003998 G4 box; other site
1074919003999 G5 box; other site
1074919004000 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1074919004001 G1 box; other site
1074919004002 GTP/Mg2+ binding site [chemical binding]; other site
1074919004003 Switch I region; other site
1074919004004 G2 box; other site
1074919004005 G3 box; other site
1074919004006 Switch II region; other site
1074919004007 G4 box; other site
1074919004008 G5 box; other site
1074919004009 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1074919004010 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1074919004011 RNA binding site [nucleotide binding]; other site
1074919004012 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1074919004013 RNA binding site [nucleotide binding]; other site
1074919004014 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1074919004015 RNA binding site [nucleotide binding]; other site
1074919004016 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1074919004017 RNA binding site [nucleotide binding]; other site
1074919004018 cytidylate kinase; Provisional; Region: cmk; PRK00023
1074919004019 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1074919004020 CMP-binding site; other site
1074919004021 The sites determining sugar specificity; other site
1074919004022 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461
1074919004023 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1074919004024 active site
1074919004025 homotetramer interface [polypeptide binding]; other site
1074919004026 homodimer interface [polypeptide binding]; other site
1074919004027 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1074919004028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1074919004029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919004030 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1074919004031 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1074919004032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919004033 ATP binding site [chemical binding]; other site
1074919004034 putative Mg++ binding site [ion binding]; other site
1074919004035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919004036 nucleotide binding region [chemical binding]; other site
1074919004037 ATP-binding site [chemical binding]; other site
1074919004038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1074919004039 Predicted membrane protein [Function unknown]; Region: COG3601
1074919004040 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1074919004041 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1074919004042 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1074919004043 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
1074919004044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1074919004045 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074919004046 dimerization interface [polypeptide binding]; other site
1074919004047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919004048 dimer interface [polypeptide binding]; other site
1074919004049 phosphorylation site [posttranslational modification]
1074919004050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919004051 ATP binding site [chemical binding]; other site
1074919004052 Mg2+ binding site [ion binding]; other site
1074919004053 G-X-G motif; other site
1074919004054 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919004055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919004056 active site
1074919004057 phosphorylation site [posttranslational modification]
1074919004058 intermolecular recognition site; other site
1074919004059 dimerization interface [polypeptide binding]; other site
1074919004060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919004061 DNA binding site [nucleotide binding]
1074919004062 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919004063 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1074919004064 pseudouridine synthase; Region: TIGR00093
1074919004065 active site
1074919004066 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1074919004067 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1074919004068 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
1074919004069 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1074919004070 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1074919004071 active site
1074919004072 Int/Topo IB signature motif; other site
1074919004073 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1074919004074 dimer interface [polypeptide binding]; other site
1074919004075 ADP-ribose binding site [chemical binding]; other site
1074919004076 active site
1074919004077 nudix motif; other site
1074919004078 metal binding site [ion binding]; metal-binding site
1074919004079 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919004080 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074919004081 active site
1074919004082 catalytic tetrad [active]
1074919004083 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1074919004084 classical (c) SDRs; Region: SDR_c; cd05233
1074919004085 NAD(P) binding site [chemical binding]; other site
1074919004086 active site
1074919004087 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1074919004088 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
1074919004089 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
1074919004090 ribonuclease Z; Region: RNase_Z; TIGR02651
1074919004091 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1074919004092 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1074919004093 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1074919004094 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1074919004095 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1074919004096 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1074919004097 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1074919004098 Ca binding site [ion binding]; other site
1074919004099 active site
1074919004100 catalytic site [active]
1074919004101 Transcriptional regulators [Transcription]; Region: PurR; COG1609
1074919004102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1074919004103 DNA binding site [nucleotide binding]
1074919004104 domain linker motif; other site
1074919004105 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1074919004106 putative ligand binding site [chemical binding]; other site
1074919004107 putative dimerization interface [polypeptide binding]; other site
1074919004108 H+ Antiporter protein; Region: 2A0121; TIGR00900
1074919004109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919004110 putative substrate translocation pore; other site
1074919004111 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1074919004112 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1074919004113 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1074919004114 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1074919004115 peptidase T-like protein; Region: PepT-like; TIGR01883
1074919004116 metal binding site [ion binding]; metal-binding site
1074919004117 putative dimer interface [polypeptide binding]; other site
1074919004118 Predicted membrane protein [Function unknown]; Region: COG4129
1074919004119 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1074919004120 DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1074919004121 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1074919004122 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1074919004123 E3 interaction surface; other site
1074919004124 lipoyl attachment site [posttranslational modification]; other site
1074919004125 e3 binding domain; Region: E3_binding; pfam02817
1074919004126 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1074919004127 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1074919004128 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1074919004129 alpha subunit interface [polypeptide binding]; other site
1074919004130 TPP binding site [chemical binding]; other site
1074919004131 heterodimer interface [polypeptide binding]; other site
1074919004132 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1074919004133 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1074919004134 tetramer interface [polypeptide binding]; other site
1074919004135 TPP-binding site [chemical binding]; other site
1074919004136 heterodimer interface [polypeptide binding]; other site
1074919004137 phosphorylation loop region [posttranslational modification]
1074919004138 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1074919004139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1074919004140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919004141 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1074919004142 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1074919004143 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1074919004144 Walker A/P-loop; other site
1074919004145 ATP binding site [chemical binding]; other site
1074919004146 Q-loop/lid; other site
1074919004147 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1074919004148 ABC transporter signature motif; other site
1074919004149 Walker B; other site
1074919004150 D-loop; other site
1074919004151 H-loop/switch region; other site
1074919004152 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1074919004153 substrate binding pocket [chemical binding]; other site
1074919004154 chain length determination region; other site
1074919004155 substrate-Mg2+ binding site; other site
1074919004156 catalytic residues [active]
1074919004157 aspartate-rich region 1; other site
1074919004158 active site lid residues [active]
1074919004159 aspartate-rich region 2; other site
1074919004160 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1074919004161 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1074919004162 generic binding surface II; other site
1074919004163 generic binding surface I; other site
1074919004164 Nucleoporin complex subunit 54; Region: Nup54; pfam13874
1074919004165 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1074919004166 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919004167 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1074919004168 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1074919004169 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1074919004170 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1074919004171 carboxyltransferase (CT) interaction site; other site
1074919004172 biotinylation site [posttranslational modification]; other site
1074919004173 elongation factor P; Validated; Region: PRK00529
1074919004174 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1074919004175 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1074919004176 RNA binding site [nucleotide binding]; other site
1074919004177 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1074919004178 RNA binding site [nucleotide binding]; other site
1074919004179 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1074919004180 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1074919004181 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1074919004182 active site
1074919004183 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1074919004184 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1074919004185 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1074919004186 tetramer interface [polypeptide binding]; other site
1074919004187 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919004188 catalytic residue [active]
1074919004189 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1074919004190 tetramer interface [polypeptide binding]; other site
1074919004191 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919004192 catalytic residue [active]
1074919004193 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1074919004194 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1074919004195 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1074919004196 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1074919004197 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1074919004198 ADP binding site [chemical binding]; other site
1074919004199 magnesium binding site [ion binding]; other site
1074919004200 putative shikimate binding site; other site
1074919004201 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1074919004202 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1074919004203 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1074919004204 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1074919004205 Type II/IV secretion system protein; Region: T2SE; pfam00437
1074919004206 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1074919004207 Walker A motif; other site
1074919004208 ATP binding site [chemical binding]; other site
1074919004209 Walker B motif; other site
1074919004210 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1074919004211 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1074919004212 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1074919004213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919004214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919004215 binding surface
1074919004216 TPR motif; other site
1074919004217 TPR repeat; Region: TPR_11; pfam13414
1074919004218 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1074919004219 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1074919004220 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1074919004221 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
1074919004222 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1074919004223 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1074919004224 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1074919004225 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1074919004226 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1074919004227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919004228 ABC-ATPase subunit interface; other site
1074919004229 dimer interface [polypeptide binding]; other site
1074919004230 putative PBP binding regions; other site
1074919004231 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1074919004232 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1074919004233 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
1074919004234 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1074919004235 AP (apurinic/apyrimidinic) site pocket; other site
1074919004236 DNA interaction; other site
1074919004237 Metal-binding active site; metal-binding site
1074919004238 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1074919004239 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1074919004240 ATP binding site [chemical binding]; other site
1074919004241 putative Mg++ binding site [ion binding]; other site
1074919004242 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919004243 nucleotide binding region [chemical binding]; other site
1074919004244 ATP-binding site [chemical binding]; other site
1074919004245 Uncharacterized conserved protein [Function unknown]; Region: COG0327
1074919004246 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1074919004247 Family of unknown function (DUF633); Region: DUF633; pfam04816
1074919004248 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1074919004249 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1074919004250 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1074919004251 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074919004252 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1074919004253 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074919004254 DNA binding residues [nucleotide binding]
1074919004255 DNA primase, catalytic core; Region: dnaG; TIGR01391
1074919004256 CHC2 zinc finger; Region: zf-CHC2; pfam01807
1074919004257 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1074919004258 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1074919004259 active site
1074919004260 metal binding site [ion binding]; metal-binding site
1074919004261 interdomain interaction site; other site
1074919004262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
1074919004263 FOG: CBS domain [General function prediction only]; Region: COG0517
1074919004264 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1074919004265 glycyl-tRNA synthetase; Provisional; Region: PRK04173
1074919004266 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1074919004267 motif 1; other site
1074919004268 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1074919004269 active site
1074919004270 motif 2; other site
1074919004271 motif 3; other site
1074919004272 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1074919004273 anticodon binding site; other site
1074919004274 DNA repair protein RecO; Region: reco; TIGR00613
1074919004275 Recombination protein O N terminal; Region: RecO_N; pfam11967
1074919004276 Recombination protein O C terminal; Region: RecO_C; pfam02565
1074919004277 GTPase Era; Reviewed; Region: era; PRK00089
1074919004278 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1074919004279 G1 box; other site
1074919004280 GTP/Mg2+ binding site [chemical binding]; other site
1074919004281 Switch I region; other site
1074919004282 G2 box; other site
1074919004283 Switch II region; other site
1074919004284 G3 box; other site
1074919004285 G4 box; other site
1074919004286 G5 box; other site
1074919004287 KH domain; Region: KH_2; pfam07650
1074919004288 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1074919004289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919004290 ATP binding site [chemical binding]; other site
1074919004291 putative Mg++ binding site [ion binding]; other site
1074919004292 DNA translocase FtsK; Provisional; Region: PRK10263
1074919004293 hypothetical protein; Provisional; Region: PRK13665
1074919004294 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1074919004295 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1074919004296 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1074919004297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919004298 FeS/SAM binding site; other site
1074919004299 TRAM domain; Region: TRAM; cl01282
1074919004300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1074919004301 RNA methyltransferase, RsmE family; Region: TIGR00046
1074919004302 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1074919004303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004304 S-adenosylmethionine binding site [chemical binding]; other site
1074919004305 chaperone protein DnaJ; Provisional; Region: PRK14280
1074919004306 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1074919004307 HSP70 interaction site [polypeptide binding]; other site
1074919004308 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1074919004309 substrate binding site [polypeptide binding]; other site
1074919004310 dimer interface [polypeptide binding]; other site
1074919004311 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1074919004312 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1074919004313 nucleotide binding site [chemical binding]; other site
1074919004314 NEF interaction site [polypeptide binding]; other site
1074919004315 SBD interface [polypeptide binding]; other site
1074919004316 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1074919004317 dimer interface [polypeptide binding]; other site
1074919004318 hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1074919004319 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1074919004320 heat shock gene repressor HrcA; Region: hrcA; TIGR00331
1074919004321 HrcA protein C terminal domain; Region: HrcA; pfam01628
1074919004322 coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1074919004323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919004324 FeS/SAM binding site; other site
1074919004325 HemN C-terminal domain; Region: HemN_C; pfam06969
1074919004326 GTP-binding protein LepA; Provisional; Region: PRK05433
1074919004327 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1074919004328 G1 box; other site
1074919004329 putative GEF interaction site [polypeptide binding]; other site
1074919004330 GTP/Mg2+ binding site [chemical binding]; other site
1074919004331 Switch I region; other site
1074919004332 G2 box; other site
1074919004333 G3 box; other site
1074919004334 Switch II region; other site
1074919004335 G4 box; other site
1074919004336 G5 box; other site
1074919004337 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1074919004338 Elongation Factor G, domain II; Region: EFG_II; pfam14492
1074919004339 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1074919004340 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1074919004341 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1074919004342 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1074919004343 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1074919004344 Competence protein; Region: Competence; pfam03772
1074919004345 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1074919004346 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1074919004347 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1074919004348 catalytic motif [active]
1074919004349 Zn binding site [ion binding]; other site
1074919004350 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1074919004351 SLBB domain; Region: SLBB; pfam10531
1074919004352 Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1074919004353 Methyltransferase domain; Region: Methyltransf_31; pfam13847
1074919004354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004355 S-adenosylmethionine binding site [chemical binding]; other site
1074919004356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919004357 Zn2+ binding site [ion binding]; other site
1074919004358 Mg2+ binding site [ion binding]; other site
1074919004359 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1074919004360 active site
1074919004361 (T/H)XGH motif; other site
1074919004362 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1074919004363 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1074919004364 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1074919004365 shikimate binding site; other site
1074919004366 NAD(P) binding site [chemical binding]; other site
1074919004367 GTPase YqeH; Provisional; Region: PRK13796
1074919004368 Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1074919004369 GTP/Mg2+ binding site [chemical binding]; other site
1074919004370 G4 box; other site
1074919004371 G5 box; other site
1074919004372 G1 box; other site
1074919004373 Switch I region; other site
1074919004374 G2 box; other site
1074919004375 G3 box; other site
1074919004376 Switch II region; other site
1074919004377 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1074919004378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919004379 active site
1074919004380 motif I; other site
1074919004381 motif II; other site
1074919004382 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1074919004383 Fic family protein [Function unknown]; Region: COG3177
1074919004384 Fic/DOC family; Region: Fic; pfam02661
1074919004385 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1074919004386 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1074919004387 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787
1074919004388 putative active site [active]
1074919004389 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1074919004390 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1074919004391 ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074919004392 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1074919004393 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1074919004394 Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1074919004395 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1074919004396 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1074919004397 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1074919004398 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1074919004399 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1074919004400 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1074919004401 Sugar specificity; other site
1074919004402 Pyrimidine base specificity; other site
1074919004403 ATP-binding site [chemical binding]; other site
1074919004404 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1074919004405 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1074919004406 Peptidase family U32; Region: Peptidase_U32; pfam01136
1074919004407 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1074919004408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004409 S-adenosylmethionine binding site [chemical binding]; other site
1074919004410 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1074919004411 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1074919004412 motif 1; other site
1074919004413 active site
1074919004414 motif 2; other site
1074919004415 motif 3; other site
1074919004416 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
1074919004417 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1074919004418 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
1074919004419 DHHA1 domain; Region: DHHA1; pfam02272
1074919004420 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1074919004421 Helix-hairpin-helix domain; Region: HHH_5; pfam14520
1074919004422 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490
1074919004423 AAA domain; Region: AAA_30; pfam13604
1074919004424 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
1074919004425 Tetratricopeptide repeat; Region: TPR_12; pfam13424
1074919004426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919004427 binding surface
1074919004428 TPR motif; other site
1074919004429 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1074919004430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1074919004431 binding surface
1074919004432 TPR motif; other site
1074919004433 TPR repeat; Region: TPR_11; pfam13414
1074919004434 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1074919004435 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1074919004436 Ligand Binding Site [chemical binding]; other site
1074919004437 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1074919004438 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919004439 catalytic residue [active]
1074919004440 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1074919004441 recombination factor protein RarA; Reviewed; Region: PRK13342
1074919004442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919004443 Walker A motif; other site
1074919004444 ATP binding site [chemical binding]; other site
1074919004445 Walker B motif; other site
1074919004446 arginine finger; other site
1074919004447 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1074919004448 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1074919004449 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1074919004450 putative ATP binding site [chemical binding]; other site
1074919004451 putative substrate interface [chemical binding]; other site
1074919004452 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1074919004453 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1074919004454 dimer interface [polypeptide binding]; other site
1074919004455 anticodon binding site; other site
1074919004456 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1074919004457 homodimer interface [polypeptide binding]; other site
1074919004458 motif 1; other site
1074919004459 active site
1074919004460 motif 2; other site
1074919004461 motif 3; other site
1074919004462 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1074919004463 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1074919004464 dimer interface [polypeptide binding]; other site
1074919004465 motif 1; other site
1074919004466 active site
1074919004467 motif 2; other site
1074919004468 motif 3; other site
1074919004469 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1074919004470 anticodon binding site; other site
1074919004471 Bacterial SH3 domain homologues; Region: SH3b; smart00287
1074919004472 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1074919004473 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1074919004474 active site
1074919004475 metal binding site [ion binding]; metal-binding site
1074919004476 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1074919004477 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919004478 Zn2+ binding site [ion binding]; other site
1074919004479 Mg2+ binding site [ion binding]; other site
1074919004480 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1074919004481 synthetase active site [active]
1074919004482 NTP binding site [chemical binding]; other site
1074919004483 metal binding site [ion binding]; metal-binding site
1074919004484 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1074919004485 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1074919004486 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919004487 active site
1074919004488 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1074919004489 DHH family; Region: DHH; pfam01368
1074919004490 DHHA1 domain; Region: DHHA1; pfam02272
1074919004491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1074919004492 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1074919004493 SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1074919004494 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1074919004495 Protein export membrane protein; Region: SecD_SecF; pfam02355
1074919004496 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1074919004497 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1074919004498 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1074919004499 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1074919004500 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1074919004501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919004502 Walker A motif; other site
1074919004503 ATP binding site [chemical binding]; other site
1074919004504 Walker B motif; other site
1074919004505 arginine finger; other site
1074919004506 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1074919004507 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1074919004508 RuvA N terminal domain; Region: RuvA_N; pfam01330
1074919004509 RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1074919004510 GTPase CgtA; Reviewed; Region: obgE; PRK12297
1074919004511 GTP1/OBG; Region: GTP1_OBG; pfam01018
1074919004512 Obg GTPase; Region: Obg; cd01898
1074919004513 G1 box; other site
1074919004514 GTP/Mg2+ binding site [chemical binding]; other site
1074919004515 Switch I region; other site
1074919004516 G2 box; other site
1074919004517 G3 box; other site
1074919004518 Switch II region; other site
1074919004519 G4 box; other site
1074919004520 G5 box; other site
1074919004521 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1074919004522 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1074919004523 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
1074919004524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004525 S-adenosylmethionine binding site [chemical binding]; other site
1074919004526 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1074919004527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004528 S-adenosylmethionine binding site [chemical binding]; other site
1074919004529 aminoglycoside resistance protein; Provisional; Region: PRK13746
1074919004530 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1074919004531 active site
1074919004532 NTP binding site [chemical binding]; other site
1074919004533 metal binding triad [ion binding]; metal-binding site
1074919004534 antibiotic binding site [chemical binding]; other site
1074919004535 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1074919004536 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919004537 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919004538 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919004539 active site
1074919004540 DNA binding site [nucleotide binding]
1074919004541 Int/Topo IB signature motif; other site
1074919004542 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235
1074919004543 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1074919004544 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1074919004545 Int/Topo IB signature motif; other site
1074919004546 hypothetical protein; Reviewed; Region: PRK00024
1074919004547 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1074919004548 MPN+ (JAMM) motif; other site
1074919004549 Zinc-binding site [ion binding]; other site
1074919004550 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1074919004551 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1074919004552 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1074919004553 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1074919004554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919004555 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919004556 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1074919004557 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1074919004558 active site
1074919004559 HIGH motif; other site
1074919004560 KMSKS motif; other site
1074919004561 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1074919004562 tRNA binding surface [nucleotide binding]; other site
1074919004563 anticodon binding site; other site
1074919004564 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1074919004565 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1074919004566 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1074919004567 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1074919004568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919004569 inhibitor-cofactor binding pocket; inhibition site
1074919004570 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919004571 catalytic residue [active]
1074919004572 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1074919004573 dimer interface [polypeptide binding]; other site
1074919004574 active site
1074919004575 Schiff base residues; other site
1074919004576 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1074919004577 active site
1074919004578 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1074919004579 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1074919004580 domain interfaces; other site
1074919004581 active site
1074919004582 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
1074919004583 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1074919004584 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1074919004585 tRNA; other site
1074919004586 putative tRNA binding site [nucleotide binding]; other site
1074919004587 putative NADP binding site [chemical binding]; other site
1074919004588 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
1074919004589 Predicted GTPase [General function prediction only]; Region: COG0218
1074919004590 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1074919004591 G1 box; other site
1074919004592 GTP/Mg2+ binding site [chemical binding]; other site
1074919004593 Switch I region; other site
1074919004594 G2 box; other site
1074919004595 G3 box; other site
1074919004596 Switch II region; other site
1074919004597 G4 box; other site
1074919004598 G5 box; other site
1074919004599 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1074919004600 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1074919004601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919004602 Walker A motif; other site
1074919004603 ATP binding site [chemical binding]; other site
1074919004604 Walker B motif; other site
1074919004605 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1074919004606 trigger factor; Provisional; Region: tig; PRK01490
1074919004607 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
1074919004608 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1074919004609 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1074919004610 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
1074919004611 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1074919004612 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1074919004613 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1074919004614 lysine transporter; Provisional; Region: PRK10836
1074919004615 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1074919004616 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1074919004617 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1074919004618 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1074919004619 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1074919004620 active site
1074919004621 dimer interface [polypeptide binding]; other site
1074919004622 motif 1; other site
1074919004623 motif 2; other site
1074919004624 motif 3; other site
1074919004625 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1074919004626 anticodon binding site; other site
1074919004627 primosomal protein DnaI; Reviewed; Region: PRK08939
1074919004628 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1074919004629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919004630 Walker A motif; other site
1074919004631 ATP binding site [chemical binding]; other site
1074919004632 Walker B motif; other site
1074919004633 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1074919004634 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1074919004635 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1074919004636 ATP cone domain; Region: ATP-cone; pfam03477
1074919004637 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
1074919004638 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1074919004639 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1074919004640 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1074919004641 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1074919004642 CoA-binding site [chemical binding]; other site
1074919004643 ATP-binding [chemical binding]; other site
1074919004644 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1074919004645 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1074919004646 DNA binding site [nucleotide binding]
1074919004647 catalytic residue [active]
1074919004648 H2TH interface [polypeptide binding]; other site
1074919004649 putative catalytic residues [active]
1074919004650 turnover-facilitating residue; other site
1074919004651 intercalation triad [nucleotide binding]; other site
1074919004652 8OG recognition residue [nucleotide binding]; other site
1074919004653 putative reading head residues; other site
1074919004654 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1074919004655 DNA polymerase I; Provisional; Region: PRK05755
1074919004656 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1074919004657 active site
1074919004658 metal binding site 1 [ion binding]; metal-binding site
1074919004659 putative 5' ssDNA interaction site; other site
1074919004660 metal binding site 3; metal-binding site
1074919004661 metal binding site 2 [ion binding]; metal-binding site
1074919004662 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1074919004663 putative DNA binding site [nucleotide binding]; other site
1074919004664 putative metal binding site [ion binding]; other site
1074919004665 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1074919004666 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1074919004667 active site
1074919004668 DNA binding site [nucleotide binding]
1074919004669 catalytic site [active]
1074919004670 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1074919004671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919004672 dimer interface [polypeptide binding]; other site
1074919004673 phosphorylation site [posttranslational modification]
1074919004674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919004675 ATP binding site [chemical binding]; other site
1074919004676 Mg2+ binding site [ion binding]; other site
1074919004677 G-X-G motif; other site
1074919004678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919004679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919004680 active site
1074919004681 phosphorylation site [posttranslational modification]
1074919004682 intermolecular recognition site; other site
1074919004683 dimerization interface [polypeptide binding]; other site
1074919004684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919004685 DNA binding site [nucleotide binding]
1074919004686 isocitrate dehydrogenase; Reviewed; Region: PRK07006
1074919004687 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1074919004688 dimer interface [polypeptide binding]; other site
1074919004689 Citrate synthase; Region: Citrate_synt; pfam00285
1074919004690 active site
1074919004691 citrylCoA binding site [chemical binding]; other site
1074919004692 oxalacetate/citrate binding site [chemical binding]; other site
1074919004693 coenzyme A binding site [chemical binding]; other site
1074919004694 catalytic triad [active]
1074919004695 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1074919004696 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1074919004697 pyruvate kinase; Provisional; Region: PRK06354
1074919004698 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
1074919004699 domain interfaces; other site
1074919004700 active site
1074919004701 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1074919004702 6-phosphofructokinase; Provisional; Region: PRK03202
1074919004703 active site
1074919004704 ADP/pyrophosphate binding site [chemical binding]; other site
1074919004705 dimerization interface [polypeptide binding]; other site
1074919004706 allosteric effector site; other site
1074919004707 fructose-1,6-bisphosphate binding site; other site
1074919004708 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1074919004709 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1074919004710 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1074919004711 Malic enzyme, N-terminal domain; Region: malic; pfam00390
1074919004712 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1074919004713 putative NAD(P) binding site [chemical binding]; other site
1074919004714 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1074919004715 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1074919004716 active site
1074919004717 PHP Thumb interface [polypeptide binding]; other site
1074919004718 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1074919004719 Helix-hairpin-helix motif; Region: HHH_6; pfam14579
1074919004720 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1074919004721 generic binding surface I; other site
1074919004722 generic binding surface II; other site
1074919004723 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1074919004724 DHH family; Region: DHH; pfam01368
1074919004725 DHHA1 domain; Region: DHHA1; pfam02272
1074919004726 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1074919004727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1074919004728 DNA-binding site [nucleotide binding]; DNA binding site
1074919004729 DRTGG domain; Region: DRTGG; pfam07085
1074919004730 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1074919004731 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1074919004732 active site 2 [active]
1074919004733 active site 1 [active]
1074919004734 metal-dependent hydrolase; Provisional; Region: PRK00685
1074919004735 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1074919004736 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1074919004737 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1074919004738 active site
1074919004739 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1074919004740 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1074919004741 hexamer interface [polypeptide binding]; other site
1074919004742 ligand binding site [chemical binding]; other site
1074919004743 putative active site [active]
1074919004744 NAD(P) binding site [chemical binding]; other site
1074919004745 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1074919004746 Ligand Binding Site [chemical binding]; other site
1074919004747 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1074919004748 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1074919004749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004750 S-adenosylmethionine binding site [chemical binding]; other site
1074919004751 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1074919004752 dimer interface [polypeptide binding]; other site
1074919004753 catalytic triad [active]
1074919004754 peroxidatic and resolving cysteines [active]
1074919004755 hypothetical protein; Provisional; Region: PRK10621
1074919004756 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1074919004757 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1074919004758 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1074919004759 Ligand Binding Site [chemical binding]; other site
1074919004760 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1074919004761 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1074919004762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919004763 catalytic residue [active]
1074919004764 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
1074919004765 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1074919004766 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1074919004767 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919004768 RNA binding surface [nucleotide binding]; other site
1074919004769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919004770 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
1074919004771 Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919004772 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1074919004773 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1074919004774 active site
1074919004775 catalytic site [active]
1074919004776 OsmC-like protein; Region: OsmC; cl00767
1074919004777 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1074919004778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919004779 catalytic residue [active]
1074919004780 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
1074919004781 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1074919004782 ligand binding site [chemical binding]; other site
1074919004783 NAD binding site [chemical binding]; other site
1074919004784 dimerization interface [polypeptide binding]; other site
1074919004785 catalytic site [active]
1074919004786 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1074919004787 putative L-serine binding site [chemical binding]; other site
1074919004788 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1074919004789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919004790 motif II; other site
1074919004791 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1074919004792 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919004793 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919004794 active site turn [active]
1074919004795 phosphorylation site [posttranslational modification]
1074919004796 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1074919004797 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1074919004798 putative acyl-acceptor binding pocket; other site
1074919004799 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1074919004800 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1074919004801 protein binding site [polypeptide binding]; other site
1074919004802 tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1074919004803 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1074919004804 active site
1074919004805 HIGH motif; other site
1074919004806 dimer interface [polypeptide binding]; other site
1074919004807 KMSKS motif; other site
1074919004808 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919004809 RNA binding surface [nucleotide binding]; other site
1074919004810 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1074919004811 Transglycosylase; Region: Transgly; pfam00912
1074919004812 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
1074919004813 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1074919004814 NEAr Transporter domain; Region: NEAT; smart00725
1074919004815 NEAr Transporter domain; Region: NEAT; smart00725
1074919004816 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1074919004817 heme-binding site [chemical binding]; other site
1074919004818 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1074919004819 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1074919004820 Potassium binding sites [ion binding]; other site
1074919004821 Cesium cation binding sites [ion binding]; other site
1074919004822 acetyl-CoA synthetase; Provisional; Region: PRK04319
1074919004823 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074919004824 acyl-activating enzyme (AAE) consensus motif; other site
1074919004825 AMP binding site [chemical binding]; other site
1074919004826 active site
1074919004827 CoA binding site [chemical binding]; other site
1074919004828 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1074919004829 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1074919004830 active site
1074919004831 Zn binding site [ion binding]; other site
1074919004832 catabolite control protein A; Region: ccpA; TIGR01481
1074919004833 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1074919004834 DNA binding site [nucleotide binding]
1074919004835 domain linker motif; other site
1074919004836 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1074919004837 dimerization interface [polypeptide binding]; other site
1074919004838 effector binding site; other site
1074919004839 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1074919004840 Chorismate mutase type II; Region: CM_2; cl00693
1074919004841 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1074919004842 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
1074919004843 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1074919004844 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1074919004845 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1074919004846 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919004847 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919004848 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1074919004849 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1074919004850 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1074919004851 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794
1074919004852 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1074919004853 putative tRNA-binding site [nucleotide binding]; other site
1074919004854 hypothetical protein; Provisional; Region: PRK13668
1074919004855 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1074919004856 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1074919004857 oligomer interface [polypeptide binding]; other site
1074919004858 active site
1074919004859 metal binding site [ion binding]; metal-binding site
1074919004860 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1074919004861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004862 S-adenosylmethionine binding site [chemical binding]; other site
1074919004863 Phosphotransferase enzyme family; Region: APH; pfam01636
1074919004864 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1074919004865 active site
1074919004866 substrate binding site [chemical binding]; other site
1074919004867 ATP binding site [chemical binding]; other site
1074919004868 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1074919004869 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1074919004870 homodimer interface [polypeptide binding]; other site
1074919004871 substrate-cofactor binding pocket; other site
1074919004872 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919004873 catalytic residue [active]
1074919004874 dipeptidase PepV; Reviewed; Region: PRK07318
1074919004875 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1074919004876 active site
1074919004877 metal binding site [ion binding]; metal-binding site
1074919004878 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1074919004879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1074919004880 RNA binding surface [nucleotide binding]; other site
1074919004881 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1074919004882 active site
1074919004883 uracil binding [chemical binding]; other site
1074919004884 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1074919004885 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1074919004886 HI0933-like protein; Region: HI0933_like; pfam03486
1074919004887 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919004888 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1074919004889 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004890 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004891 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004892 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004893 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004894 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004895 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004896 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004897 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004898 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004899 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004900 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004901 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004902 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004903 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919004904 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1074919004905 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1074919004906 HIGH motif; other site
1074919004907 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1074919004908 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1074919004909 active site
1074919004910 KMSKS motif; other site
1074919004911 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1074919004912 tRNA binding surface [nucleotide binding]; other site
1074919004913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919004914 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919004915 putative substrate translocation pore; other site
1074919004916 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1074919004917 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1074919004918 Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1074919004919 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919004920 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1074919004921 Putative lysophospholipase; Region: Hydrolase_4; cl19140
1074919004922 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1074919004923 Proline dehydrogenase; Region: Pro_dh; pfam01619
1074919004924 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1074919004925 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1074919004926 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1074919004927 dimerization interface [polypeptide binding]; other site
1074919004928 active site
1074919004929 Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307
1074919004930 Lumazine binding domain; Region: Lum_binding; pfam00677
1074919004931 Lumazine binding domain; Region: Lum_binding; pfam00677
1074919004932 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1074919004933 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1074919004934 catalytic motif [active]
1074919004935 Zn binding site [ion binding]; other site
1074919004936 RibD C-terminal domain; Region: RibD_C; cl17279
1074919004937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1074919004938 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1074919004939 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1074919004940 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1074919004941 transmembrane helices; other site
1074919004942 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1074919004943 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1074919004944 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1074919004945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1074919004946 DNA binding residues [nucleotide binding]
1074919004947 CAAX protease self-immunity; Region: Abi; pfam02517
1074919004948 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1074919004949 active site
1074919004950 intersubunit interactions; other site
1074919004951 catalytic residue [active]
1074919004952 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1074919004953 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919004954 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074919004955 active site
1074919004956 catalytic tetrad [active]
1074919004957 S-adenosylmethionine synthetase; Validated; Region: PRK05250
1074919004958 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1074919004959 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1074919004960 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1074919004961 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1074919004962 active site
1074919004963 substrate-binding site [chemical binding]; other site
1074919004964 metal-binding site [ion binding]
1074919004965 ATP binding site [chemical binding]; other site
1074919004966 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1074919004967 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1074919004968 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
1074919004969 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1074919004970 nudix motif; other site
1074919004971 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1074919004972 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1074919004973 metal binding site [ion binding]; metal-binding site
1074919004974 substrate binding pocket [chemical binding]; other site
1074919004975 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1074919004976 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
1074919004977 acyl-activating enzyme (AAE) consensus motif; other site
1074919004978 putative AMP binding site [chemical binding]; other site
1074919004979 putative active site [active]
1074919004980 putative CoA binding site [chemical binding]; other site
1074919004981 Excalibur calcium-binding domain; Region: Excalibur; smart00894
1074919004982 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1074919004983 Integrase core domain; Region: rve; pfam00665
1074919004984 DDE domain; Region: DDE_Tnp_IS240; pfam13610
1074919004985 Integrase core domain; Region: rve_3; pfam13683
1074919004986 Winged helix-turn helix; Region: HTH_29; pfam13551
1074919004987 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1074919004988 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1074919004989 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1074919004990 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1074919004991 HsdM N-terminal domain; Region: HsdM_N; pfam12161
1074919004992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919004993 S-adenosylmethionine binding site [chemical binding]; other site
1074919004994 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919004995 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919004996 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919004997 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919004998 Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1074919004999 Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1074919005000 beta-channel forming cytolysin; Region: hlyII; TIGR01002
1074919005001 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1074919005002 Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1074919005003 Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1074919005004 Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1074919005005 Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1074919005006 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005007 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005008 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005009 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005010 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005011 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005012 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005013 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005014 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005015 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005016 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1074919005017 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1074919005018 protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1074919005019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074919005020 ferrochelatase; Provisional; Region: PRK12435
1074919005021 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1074919005022 C-terminal domain interface [polypeptide binding]; other site
1074919005023 active site
1074919005024 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1074919005025 active site
1074919005026 N-terminal domain interface [polypeptide binding]; other site
1074919005027 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1074919005028 substrate binding site [chemical binding]; other site
1074919005029 active site
1074919005030 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1074919005031 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
1074919005032 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1074919005033 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919005034 Walker A/P-loop; other site
1074919005035 ATP binding site [chemical binding]; other site
1074919005036 Q-loop/lid; other site
1074919005037 ABC transporter signature motif; other site
1074919005038 Walker B; other site
1074919005039 D-loop; other site
1074919005040 H-loop/switch region; other site
1074919005041 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1074919005042 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
1074919005043 SurA N-terminal domain; Region: SurA_N_3; cl07813
1074919005044 PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1074919005045 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1074919005046 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1074919005047 generic binding surface I; other site
1074919005048 generic binding surface II; other site
1074919005049 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919005050 Zn2+ binding site [ion binding]; other site
1074919005051 Mg2+ binding site [ion binding]; other site
1074919005052 Uncharacterized conserved protein [Function unknown]; Region: COG4717
1074919005053 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
1074919005054 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1074919005055 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1074919005056 active site
1074919005057 metal binding site [ion binding]; metal-binding site
1074919005058 DNA binding site [nucleotide binding]
1074919005059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1074919005060 Protein of unknown function (DUF445); Region: DUF445; pfam04286
1074919005061 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074919005062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919005063 non-specific DNA binding site [nucleotide binding]; other site
1074919005064 salt bridge; other site
1074919005065 sequence-specific DNA binding site [nucleotide binding]; other site
1074919005066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074919005067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919005068 active site
1074919005069 phosphorylation site [posttranslational modification]
1074919005070 intermolecular recognition site; other site
1074919005071 dimerization interface [polypeptide binding]; other site
1074919005072 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074919005073 DNA binding residues [nucleotide binding]
1074919005074 dimerization interface [polypeptide binding]; other site
1074919005075 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1074919005076 GAF domain; Region: GAF_3; pfam13492
1074919005077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074919005078 Histidine kinase; Region: HisKA_3; pfam07730
1074919005079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919005080 ATP binding site [chemical binding]; other site
1074919005081 Mg2+ binding site [ion binding]; other site
1074919005082 G-X-G motif; other site
1074919005083 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1074919005084 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1074919005085 active site
1074919005086 fumarate hydratase; Reviewed; Region: fumC; PRK00485
1074919005087 Class II fumarases; Region: Fumarase_classII; cd01362
1074919005088 active site
1074919005089 tetramer interface [polypeptide binding]; other site
1074919005090 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
1074919005091 active site
1074919005092 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1074919005093 epoxyqueuosine reductase; Region: TIGR00276
1074919005094 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1074919005095 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
1074919005096 HEAT repeats; Region: HEAT_2; pfam13646
1074919005097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919005098 ABC transporter; Region: ABC_tran; pfam00005
1074919005099 Q-loop/lid; other site
1074919005100 ABC transporter signature motif; other site
1074919005101 Walker B; other site
1074919005102 D-loop; other site
1074919005103 H-loop/switch region; other site
1074919005104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1074919005105 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1074919005106 substrate binding pocket [chemical binding]; other site
1074919005107 membrane-bound complex binding site; other site
1074919005108 hinge residues; other site
1074919005109 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1074919005110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919005111 dimer interface [polypeptide binding]; other site
1074919005112 conserved gate region; other site
1074919005113 putative PBP binding loops; other site
1074919005114 ABC-ATPase subunit interface; other site
1074919005115 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1074919005116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919005117 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
1074919005118 Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919005119 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
1074919005120 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1074919005121 putative ligand binding site [chemical binding]; other site
1074919005122 NAD binding site [chemical binding]; other site
1074919005123 catalytic site [active]
1074919005124 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1074919005125 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1074919005126 catalytic triad [active]
1074919005127 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
1074919005128 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919005129 inhibitor-cofactor binding pocket; inhibition site
1074919005130 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919005131 catalytic residue [active]
1074919005132 Predicted membrane protein [Function unknown]; Region: COG4129
1074919005133 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1074919005134 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1074919005135 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919005136 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1074919005137 Walker A/P-loop; other site
1074919005138 ATP binding site [chemical binding]; other site
1074919005139 Q-loop/lid; other site
1074919005140 ABC transporter signature motif; other site
1074919005141 Walker B; other site
1074919005142 D-loop; other site
1074919005143 H-loop/switch region; other site
1074919005144 hypothetical protein; Provisional; Region: PRK13662
1074919005145 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1074919005146 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1074919005147 minor groove reading motif; other site
1074919005148 helix-hairpin-helix signature motif; other site
1074919005149 substrate binding pocket [chemical binding]; other site
1074919005150 active site
1074919005151 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1074919005152 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1074919005153 DNA binding and oxoG recognition site [nucleotide binding]
1074919005154 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1074919005155 ABC-2 type transporter; Region: ABC2_membrane; cl17235
1074919005156 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1074919005157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919005158 Walker A/P-loop; other site
1074919005159 ATP binding site [chemical binding]; other site
1074919005160 Q-loop/lid; other site
1074919005161 ABC transporter signature motif; other site
1074919005162 Walker B; other site
1074919005163 H-loop/switch region; other site
1074919005164 recombination regulator RecX; Provisional; Region: recX; PRK14135
1074919005165 glycosyltransferase; Provisional; Region: PRK13481
1074919005166 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1074919005167 intracellular protease, PfpI family; Region: PfpI; TIGR01382
1074919005168 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1074919005169 proposed catalytic triad [active]
1074919005170 conserved cys residue [active]
1074919005171 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1074919005172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919005173 FeS/SAM binding site; other site
1074919005174 YfkB-like domain; Region: YfkB; pfam08756
1074919005175 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1074919005176 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1074919005177 Low molecular weight phosphatase family; Region: LMWPc; cd00115
1074919005178 active site
1074919005179 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1074919005180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074919005181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919005182 active site
1074919005183 phosphorylation site [posttranslational modification]
1074919005184 intermolecular recognition site; other site
1074919005185 dimerization interface [polypeptide binding]; other site
1074919005186 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074919005187 DNA binding residues [nucleotide binding]
1074919005188 dimerization interface [polypeptide binding]; other site
1074919005189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074919005190 Histidine kinase; Region: HisKA_3; pfam07730
1074919005191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919005192 ATP binding site [chemical binding]; other site
1074919005193 Mg2+ binding site [ion binding]; other site
1074919005194 G-X-G motif; other site
1074919005195 Predicted membrane protein [Function unknown]; Region: COG4758
1074919005196 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1074919005197 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1074919005198 active site
1074919005199 Predicted membrane protein [Function unknown]; Region: COG4129
1074919005200 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1074919005201 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1074919005202 catalytic triad [active]
1074919005203 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1074919005204 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919005205 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1074919005206 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1074919005207 Ferritin-like domain; Region: Ferritin; pfam00210
1074919005208 ferroxidase diiron center [ion binding]; other site
1074919005209 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1074919005210 active site
1074919005211 catalytic site [active]
1074919005212 substrate binding site [chemical binding]; other site
1074919005213 DNA polymerase IV; Validated; Region: PRK02406
1074919005214 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1074919005215 active site
1074919005216 DNA binding site [nucleotide binding]
1074919005217 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1074919005218 TRAM domain; Region: TRAM; cl01282
1074919005219 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1074919005220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919005221 S-adenosylmethionine binding site [chemical binding]; other site
1074919005222 putative lipid kinase; Reviewed; Region: PRK13337
1074919005223 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1074919005224 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
1074919005225 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1074919005226 GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1074919005227 GatB domain; Region: GatB_Yqey; pfam02637
1074919005228 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1074919005229 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1074919005230 Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1074919005231 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1074919005232 Na binding site [ion binding]; other site
1074919005233 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
1074919005234 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1074919005235 putative dimer interface [polypeptide binding]; other site
1074919005236 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1074919005237 putative dimer interface [polypeptide binding]; other site
1074919005238 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1074919005239 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1074919005240 nucleotide binding pocket [chemical binding]; other site
1074919005241 K-X-D-G motif; other site
1074919005242 catalytic site [active]
1074919005243 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1074919005244 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1074919005245 Helix-hairpin-helix domain; Region: HHH_5; pfam14520
1074919005246 Helix-hairpin-helix motif; Region: HHH_2; pfam12826
1074919005247 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1074919005248 Dimer interface [polypeptide binding]; other site
1074919005249 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1074919005250 Part of AAA domain; Region: AAA_19; pfam13245
1074919005251 Family description; Region: UvrD_C_2; pfam13538
1074919005252 PcrB family; Region: PcrB; pfam01884
1074919005253 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1074919005254 substrate binding site [chemical binding]; other site
1074919005255 putative active site [active]
1074919005256 dimer interface [polypeptide binding]; other site
1074919005257 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1074919005258 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1074919005259 tetramer interface [polypeptide binding]; other site
1074919005260 active site
1074919005261 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1074919005262 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
1074919005263 hypothetical protein; Provisional; Region: PRK04164
1074919005264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
1074919005265 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1074919005266 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1074919005267 homodimer interface [polypeptide binding]; other site
1074919005268 NAD binding pocket [chemical binding]; other site
1074919005269 ATP binding pocket [chemical binding]; other site
1074919005270 Mg binding site [ion binding]; other site
1074919005271 active-site loop [active]
1074919005272 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1074919005273 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1074919005274 active site
1074919005275 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
1074919005276 active site
1074919005277 dimer interface [polypeptide binding]; other site
1074919005278 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1074919005279 Prephenate dehydratase; Region: PDT; pfam00800
1074919005280 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1074919005281 putative L-Phe binding site [chemical binding]; other site
1074919005282 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1074919005283 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1074919005284 transmembrane helices; other site
1074919005285 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1074919005286 Isochorismatase family; Region: Isochorismatase; pfam00857
1074919005287 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1074919005288 catalytic triad [active]
1074919005289 conserved cis-peptide bond; other site
1074919005290 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1074919005291 DHH family; Region: DHH; pfam01368
1074919005292 DHHA2 domain; Region: DHHA2; pfam02833
1074919005293 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1074919005294 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1074919005295 NAD(P) binding site [chemical binding]; other site
1074919005296 catalytic residues [active]
1074919005297 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
1074919005298 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
1074919005299 active site
1074919005300 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
1074919005301 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1074919005302 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1074919005303 Bacterial PH domain; Region: bPH_2; cl01348
1074919005304 Thioredoxin; Region: Thioredoxin_9; pfam14595
1074919005305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919005306 ABC transporter; Region: ABC_tran; pfam00005
1074919005307 Q-loop/lid; other site
1074919005308 ABC transporter signature motif; other site
1074919005309 Walker B; other site
1074919005310 D-loop; other site
1074919005311 H-loop/switch region; other site
1074919005312 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1074919005313 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1074919005314 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1074919005315 Walker A/P-loop; other site
1074919005316 ATP binding site [chemical binding]; other site
1074919005317 Q-loop/lid; other site
1074919005318 ABC transporter signature motif; other site
1074919005319 Walker B; other site
1074919005320 D-loop; other site
1074919005321 H-loop/switch region; other site
1074919005322 hypothetical protein; Provisional; Region: PRK08637
1074919005323 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919005324 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919005325 homodimer interface [polypeptide binding]; other site
1074919005326 catalytic residue [active]
1074919005327 superantigen-like protein 7; Reviewed; Region: PRK13346
1074919005328 MAP domain; Region: MAP; pfam03642
1074919005329 MAP domain; Region: MAP; pfam03642
1074919005330 MAP domain; Region: MAP; pfam03642
1074919005331 MAP domain; Region: MAP; pfam03642
1074919005332 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
1074919005333 CHAP domain; Region: CHAP; pfam05257
1074919005334 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
1074919005335 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
1074919005336 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
1074919005337 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1074919005338 Phage tail protein; Region: Sipho_tail; cl17486
1074919005339 Phage tail protein; Region: Sipho_tail; cl17486
1074919005340 Phage-related minor tail protein [Function unknown]; Region: COG5280
1074919005341 Phage-related protein [Function unknown]; Region: COG5412
1074919005342 Peptidase family M23; Region: Peptidase_M23; pfam01551
1074919005343 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074919005344 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254
1074919005345 N-acetyl-D-glucosamine binding site [chemical binding]; other site
1074919005346 catalytic residue [active]
1074919005347 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1074919005348 Phage capsid family; Region: Phage_capsid; cl19393
1074919005349 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1074919005350 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1074919005351 oligomer interface [polypeptide binding]; other site
1074919005352 active site residues [active]
1074919005353 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1074919005354 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1074919005355 dUTPase; Region: dUTPase_2; pfam08761
1074919005356 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1074919005357 active site
1074919005358 homodimer interface [polypeptide binding]; other site
1074919005359 metal binding site [ion binding]; metal-binding site
1074919005360 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
1074919005361 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1074919005362 Walker A motif; other site
1074919005363 ATP binding site [chemical binding]; other site
1074919005364 Walker B motif; other site
1074919005365 DNA binding loops [nucleotide binding]
1074919005366 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1074919005367 Protein of unknown function (DUF968); Region: DUF968; pfam06147
1074919005368 NUMOD4 motif; Region: NUMOD4; pfam07463
1074919005369 HNH endonuclease; Region: HNH_3; pfam13392
1074919005370 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378
1074919005371 chaperonin GroEL; Reviewed; Region: groEL; PRK12850
1074919005372 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1074919005373 ring oligomerisation interface [polypeptide binding]; other site
1074919005374 ATP/Mg binding site [chemical binding]; other site
1074919005375 stacking interactions; other site
1074919005376 hinge regions; other site
1074919005377 CAAX protease self-immunity; Region: Abi; pfam02517
1074919005378 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1074919005379 dimer interface [polypeptide binding]; other site
1074919005380 FMN binding site [chemical binding]; other site
1074919005381 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1074919005382 putative active site [active]
1074919005383 catalytic triad [active]
1074919005384 putative dimer interface [polypeptide binding]; other site
1074919005385 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512
1074919005386 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1074919005387 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1074919005388 Mg2+ binding site [ion binding]; other site
1074919005389 G-X-G motif; other site
1074919005390 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1074919005391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919005392 active site
1074919005393 phosphorylation site [posttranslational modification]
1074919005394 intermolecular recognition site; other site
1074919005395 dimerization interface [polypeptide binding]; other site
1074919005396 LytTr DNA-binding domain; Region: LytTR; pfam04397
1074919005397 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1074919005398 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1074919005399 putative ATP binding site [chemical binding]; other site
1074919005400 putative substrate binding site [chemical binding]; other site
1074919005401 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1074919005402 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1074919005403 substrate binding [chemical binding]; other site
1074919005404 active site
1074919005405 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1074919005406 Transcriptional regulators [Transcription]; Region: PurR; COG1609
1074919005407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1074919005408 DNA binding site [nucleotide binding]
1074919005409 domain linker motif; other site
1074919005410 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1074919005411 dimerization interface [polypeptide binding]; other site
1074919005412 ligand binding site [chemical binding]; other site
1074919005413 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1074919005414 Predicted transporter component [General function prediction only]; Region: COG2391
1074919005415 Sulphur transport; Region: Sulf_transp; cl19477
1074919005416 Sulphur transport; Region: Sulf_transp; cl19477
1074919005417 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
1074919005418 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1074919005419 CoA binding domain; Region: CoA_binding; pfam02629
1074919005420 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1074919005421 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919005422 ABC transporter; Region: ABC_tran_2; pfam12848
1074919005423 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1074919005424 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
1074919005425 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
1074919005426 Walker A/P-loop; other site
1074919005427 ATP binding site [chemical binding]; other site
1074919005428 Q-loop/lid; other site
1074919005429 ABC transporter signature motif; other site
1074919005430 Walker B; other site
1074919005431 D-loop; other site
1074919005432 H-loop/switch region; other site
1074919005433 UGMP family protein; Validated; Region: PRK09604
1074919005434 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1074919005435 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1074919005436 Glycoprotease family; Region: Peptidase_M22; pfam00814
1074919005437 Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1074919005438 dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1074919005439 6-phosphogluconate dehydratase; Region: edd; TIGR01196
1074919005440 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
1074919005441 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1074919005442 PYR/PP interface [polypeptide binding]; other site
1074919005443 dimer interface [polypeptide binding]; other site
1074919005444 TPP binding site [chemical binding]; other site
1074919005445 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074919005446 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1074919005447 TPP-binding site [chemical binding]; other site
1074919005448 dimer interface [polypeptide binding]; other site
1074919005449 ketol-acid reductoisomerase; Provisional; Region: PRK05479
1074919005450 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1074919005451 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1074919005452 2-isopropylmalate synthase; Validated; Region: PRK00915
1074919005453 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1074919005454 active site
1074919005455 catalytic residues [active]
1074919005456 metal binding site [ion binding]; metal-binding site
1074919005457 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502
1074919005458 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1074919005459 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1074919005460 substrate binding site [chemical binding]; other site
1074919005461 ligand binding site [chemical binding]; other site
1074919005462 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1074919005463 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1074919005464 substrate binding site [chemical binding]; other site
1074919005465 threonine dehydratase; Validated; Region: PRK08639
1074919005466 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1074919005467 tetramer interface [polypeptide binding]; other site
1074919005468 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919005469 catalytic residue [active]
1074919005470 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1074919005471 putative Ile/Val binding site [chemical binding]; other site
1074919005472 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1074919005473 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1074919005474 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1074919005475 Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1074919005476 Death-like domain of SPT6; Region: DLD; pfam14878
1074919005477 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1074919005478 RNA binding site [nucleotide binding]; other site
1074919005479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1074919005480 Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1074919005481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1074919005482 DNA binding residues [nucleotide binding]
1074919005483 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1074919005484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919005485 ATP binding site [chemical binding]; other site
1074919005486 Mg2+ binding site [ion binding]; other site
1074919005487 G-X-G motif; other site
1074919005488 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1074919005489 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
1074919005490 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1074919005491 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1074919005492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1074919005493 active site
1074919005494 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919005495 dimer interface [polypeptide binding]; other site
1074919005496 substrate binding site [chemical binding]; other site
1074919005497 catalytic residues [active]
1074919005498 Uncharacterized conserved protein [Function unknown]; Region: COG3402
1074919005499 Predicted membrane protein [Function unknown]; Region: COG3428
1074919005500 Bacterial PH domain; Region: DUF304; pfam03703
1074919005501 Bacterial PH domain; Region: DUF304; pfam03703
1074919005502 Bacterial PH domain; Region: bPH_2; cl01348
1074919005503 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998
1074919005504 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
1074919005505 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1074919005506 Soluble P-type ATPase [General function prediction only]; Region: COG4087
1074919005507 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
1074919005508 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1074919005509 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1074919005510 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1074919005511 Ligand Binding Site [chemical binding]; other site
1074919005512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919005514 dimer interface [polypeptide binding]; other site
1074919005515 phosphorylation site [posttranslational modification]
1074919005516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919005517 ATP binding site [chemical binding]; other site
1074919005518 Mg2+ binding site [ion binding]; other site
1074919005519 G-X-G motif; other site
1074919005520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919005521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919005522 active site
1074919005523 phosphorylation site [posttranslational modification]
1074919005524 intermolecular recognition site; other site
1074919005525 dimerization interface [polypeptide binding]; other site
1074919005526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919005527 DNA binding site [nucleotide binding]
1074919005528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1074919005529 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
1074919005530 Transposase; Region: DDE_Tnp_ISL3; pfam01610
1074919005531 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1074919005532 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268
1074919005533 ATP binding site [chemical binding]; other site
1074919005534 Mg++ binding site [ion binding]; other site
1074919005535 motif III; other site
1074919005536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919005537 nucleotide binding region [chemical binding]; other site
1074919005538 ATP-binding site [chemical binding]; other site
1074919005539 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1074919005540 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1074919005541 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1074919005542 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1074919005543 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1074919005544 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1074919005545 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1074919005546 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1074919005547 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1074919005548 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1074919005549 putative active site [active]
1074919005550 catalytic site [active]
1074919005551 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1074919005552 putative active site [active]
1074919005553 catalytic site [active]
1074919005554 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1074919005555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1074919005556 Zn2+ binding site [ion binding]; other site
1074919005557 Mg2+ binding site [ion binding]; other site
1074919005558 60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1074919005559 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1074919005560 thiamine phosphate binding site [chemical binding]; other site
1074919005561 active site
1074919005562 pyrophosphate binding site [ion binding]; other site
1074919005563 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1074919005564 multimerization interface [polypeptide binding]; other site
1074919005565 ATP binding site [chemical binding]; other site
1074919005566 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1074919005567 substrate binding site [chemical binding]; other site
1074919005568 dimer interface [polypeptide binding]; other site
1074919005569 ATP binding site [chemical binding]; other site
1074919005570 thiaminase II; Region: salvage_TenA; TIGR04306
1074919005571 Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1074919005572 YwpF-like protein; Region: YwpF; pfam14183
1074919005573 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1074919005574 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1074919005575 hinge; other site
1074919005576 active site
1074919005577 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1074919005578 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1074919005579 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1074919005580 alpha subunit interaction interface [polypeptide binding]; other site
1074919005581 Walker A motif; other site
1074919005582 ATP binding site [chemical binding]; other site
1074919005583 Walker B motif; other site
1074919005584 inhibitor binding site; inhibition site
1074919005585 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1074919005586 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1074919005587 core domain interface [polypeptide binding]; other site
1074919005588 delta subunit interface [polypeptide binding]; other site
1074919005589 epsilon subunit interface [polypeptide binding]; other site
1074919005590 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1074919005591 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1074919005592 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1074919005593 beta subunit interaction interface [polypeptide binding]; other site
1074919005594 Walker A motif; other site
1074919005595 ATP binding site [chemical binding]; other site
1074919005596 Walker B motif; other site
1074919005597 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1074919005598 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1074919005599 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
1074919005600 F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1074919005601 F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1074919005602 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1074919005603 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1074919005604 active site
1074919005605 homodimer interface [polypeptide binding]; other site
1074919005606 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1074919005607 active site
1074919005608 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1074919005609 dimer interface [polypeptide binding]; other site
1074919005610 active site
1074919005611 glycine-pyridoxal phosphate binding site [chemical binding]; other site
1074919005612 folate binding site [chemical binding]; other site
1074919005613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4475
1074919005614 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1074919005615 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1074919005616 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1074919005617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919005618 S-adenosylmethionine binding site [chemical binding]; other site
1074919005619 peptide chain release factor 1; Validated; Region: prfA; PRK00591
1074919005620 This domain is found in peptide chain release factors; Region: PCRF; smart00937
1074919005621 RF-1 domain; Region: RF-1; pfam00472
1074919005622 thymidine kinase; Provisional; Region: PRK04296
1074919005623 transcription termination factor Rho; Provisional; Region: rho; PRK09376
1074919005624 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1074919005625 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1074919005626 RNA binding site [nucleotide binding]; other site
1074919005627 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1074919005628 multimer interface [polypeptide binding]; other site
1074919005629 Walker A motif; other site
1074919005630 ATP binding site [chemical binding]; other site
1074919005631 Walker B motif; other site
1074919005632 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1074919005633 NAD binding site [chemical binding]; other site
1074919005634 catalytic residues [active]
1074919005635 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
1074919005636 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1074919005637 hinge; other site
1074919005638 active site
1074919005639 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1074919005640 intersubunit interface [polypeptide binding]; other site
1074919005641 active site
1074919005642 zinc binding site [ion binding]; other site
1074919005643 Na+ binding site [ion binding]; other site
1074919005644 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1074919005645 CTP synthetase; Validated; Region: pyrG; PRK05380
1074919005646 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1074919005647 Catalytic site [active]
1074919005648 active site
1074919005649 UTP binding site [chemical binding]; other site
1074919005650 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1074919005651 active site
1074919005652 putative oxyanion hole; other site
1074919005653 catalytic triad [active]
1074919005654 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343
1074919005655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919005656 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1074919005657 Coenzyme A binding pocket [chemical binding]; other site
1074919005658 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919005659 Coenzyme A binding pocket [chemical binding]; other site
1074919005660 pantothenate kinase; Provisional; Region: PRK13317
1074919005661 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
1074919005662 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1074919005663 ATP-grasp domain; Region: ATP-grasp_4; cl17255
1074919005664 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1074919005665 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1074919005666 metal binding site [ion binding]; metal-binding site
1074919005667 S-ribosylhomocysteinase; Provisional; Region: PRK02260
1074919005668 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1074919005669 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1074919005670 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1074919005671 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1074919005672 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1074919005673 intersubunit interface [polypeptide binding]; other site
1074919005674 active site
1074919005675 catalytic residue [active]
1074919005676 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1074919005677 EVE domain; Region: EVE; cl00728
1074919005678 EVE domain; Region: EVE; pfam01878
1074919005679 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1074919005680 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057
1074919005681 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1074919005682 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1074919005683 NAD(P) binding site [chemical binding]; other site
1074919005684 putative active site [active]
1074919005685 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1074919005686 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1074919005687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919005688 S-adenosylmethionine binding site [chemical binding]; other site
1074919005689 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1074919005690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919005691 S-adenosylmethionine binding site [chemical binding]; other site
1074919005692 aminoglycoside resistance protein; Provisional; Region: PRK13746
1074919005693 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1074919005694 active site
1074919005695 NTP binding site [chemical binding]; other site
1074919005696 metal binding triad [ion binding]; metal-binding site
1074919005697 antibiotic binding site [chemical binding]; other site
1074919005698 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1074919005699 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919005700 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919005701 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919005702 active site
1074919005703 DNA binding site [nucleotide binding]
1074919005704 Int/Topo IB signature motif; other site
1074919005705 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235
1074919005706 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1074919005707 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1074919005708 Int/Topo IB signature motif; other site
1074919005709 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1074919005710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919005711 active site
1074919005712 motif I; other site
1074919005713 motif II; other site
1074919005714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919005715 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1074919005716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919005717 Walker A/P-loop; other site
1074919005718 ATP binding site [chemical binding]; other site
1074919005719 Q-loop/lid; other site
1074919005720 ABC transporter signature motif; other site
1074919005721 Walker B; other site
1074919005722 D-loop; other site
1074919005723 H-loop/switch region; other site
1074919005724 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1074919005725 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1074919005726 glutaminase active site [active]
1074919005727 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1074919005728 dimer interface [polypeptide binding]; other site
1074919005729 active site
1074919005730 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1074919005731 dimer interface [polypeptide binding]; other site
1074919005732 active site
1074919005733 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1074919005734 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1074919005735 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1074919005736 active site
1074919005737 P-loop; other site
1074919005738 phosphorylation site [posttranslational modification]
1074919005739 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919005740 HTH domain; Region: HTH_11; pfam08279
1074919005741 Mga helix-turn-helix domain; Region: Mga; pfam05043
1074919005742 PRD domain; Region: PRD; pfam00874
1074919005743 PRD domain; Region: PRD; pfam00874
1074919005744 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1074919005745 active site
1074919005746 P-loop; other site
1074919005747 phosphorylation site [posttranslational modification]
1074919005748 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1074919005749 active site
1074919005750 phosphorylation site [posttranslational modification]
1074919005751 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1074919005752 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1074919005753 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1074919005754 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1074919005755 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
1074919005756 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005757 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005758 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005759 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005760 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005761 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005762 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005763 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005764 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005765 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005766 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005767 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005768 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005769 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005770 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005771 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
1074919005772 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1074919005773 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1074919005774 active site
1074919005775 substrate binding site [chemical binding]; other site
1074919005776 metal binding site [ion binding]; metal-binding site
1074919005777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1074919005778 YbbR-like protein; Region: YbbR; pfam07949
1074919005779 YbbR-like protein; Region: YbbR; pfam07949
1074919005780 TIGR00159 family protein; Region: TIGR00159
1074919005781 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1074919005782 Arginase family; Region: Arginase; cd09989
1074919005783 active site
1074919005784 Mn binding site [ion binding]; other site
1074919005785 oligomer interface [polypeptide binding]; other site
1074919005786 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1074919005787 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1074919005788 Walker A motif; other site
1074919005789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1074919005790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005791 putative substrate translocation pore; other site
1074919005792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005793 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919005794 putative substrate translocation pore; other site
1074919005795 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1074919005796 channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1074919005797 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
1074919005798 substrate binding site; other site
1074919005799 dimerization interface; other site
1074919005800 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1074919005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1074919005802 Nucleoside recognition; Region: Gate; pfam07670
1074919005803 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1074919005804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919005805 ABC-ATPase subunit interface; other site
1074919005806 dimer interface [polypeptide binding]; other site
1074919005807 putative PBP binding regions; other site
1074919005808 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1074919005809 ABC-ATPase subunit interface; other site
1074919005810 dimer interface [polypeptide binding]; other site
1074919005811 putative PBP binding regions; other site
1074919005812 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1074919005813 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1074919005814 siderophore binding site; other site
1074919005815 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
1074919005816 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
1074919005817 dimer interface [polypeptide binding]; other site
1074919005818 active site
1074919005819 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1074919005820 substrate binding site [chemical binding]; other site
1074919005821 catalytic residue [active]
1074919005822 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919005823 IucA / IucC family; Region: IucA_IucC; pfam04183
1074919005824 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919005825 H+ Antiporter protein; Region: 2A0121; TIGR00900
1074919005826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005827 putative substrate translocation pore; other site
1074919005828 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1074919005829 IucA / IucC family; Region: IucA_IucC; pfam04183
1074919005830 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1074919005831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1074919005832 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1074919005833 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1074919005834 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1074919005835 putative NAD(P) binding site [chemical binding]; other site
1074919005836 dimer interface [polypeptide binding]; other site
1074919005837 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1074919005838 Prostaglandin dehydrogenases; Region: PGDH; cd05288
1074919005839 NAD(P) binding site [chemical binding]; other site
1074919005840 substrate binding site [chemical binding]; other site
1074919005841 dimer interface [polypeptide binding]; other site
1074919005842 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
1074919005843 6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1074919005844 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1074919005845 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
1074919005846 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1074919005847 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1074919005848 active site
1074919005849 P-loop; other site
1074919005850 phosphorylation site [posttranslational modification]
1074919005851 tagatose 1,6-diphosphate aldolase; Region: lacD; TIGR01232
1074919005852 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1074919005853 tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1074919005854 putative substrate binding site [chemical binding]; other site
1074919005855 putative ATP binding site [chemical binding]; other site
1074919005856 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1074919005857 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1074919005858 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1074919005859 DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1074919005860 NAD-dependent deacetylase; Provisional; Region: PRK00481
1074919005861 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
1074919005862 NAD+ binding site [chemical binding]; other site
1074919005863 substrate binding site [chemical binding]; other site
1074919005864 putative Zn binding site [ion binding]; other site
1074919005865 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1074919005866 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1074919005867 active site
1074919005868 catalytic tetrad [active]
1074919005869 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1074919005870 MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1074919005871 DNA binding residues [nucleotide binding]
1074919005872 putative dimer interface [polypeptide binding]; other site
1074919005873 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1074919005874 substrate binding site [chemical binding]; other site
1074919005875 catalytic residues [active]
1074919005876 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1074919005877 Peptidase family M23; Region: Peptidase_M23; pfam01551
1074919005878 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1074919005879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1074919005880 active site
1074919005881 motif I; other site
1074919005882 motif II; other site
1074919005883 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1074919005884 acetolactate synthase; Reviewed; Region: PRK08617
1074919005885 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1074919005886 PYR/PP interface [polypeptide binding]; other site
1074919005887 dimer interface [polypeptide binding]; other site
1074919005888 TPP binding site [chemical binding]; other site
1074919005889 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074919005890 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1074919005891 TPP-binding site [chemical binding]; other site
1074919005892 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1074919005893 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
1074919005894 putative active site [active]
1074919005895 putative NTP binding site [chemical binding]; other site
1074919005896 putative nucleic acid binding site [nucleotide binding]; other site
1074919005897 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1074919005898 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1074919005899 dimerization interface 3.5A [polypeptide binding]; other site
1074919005900 active site
1074919005901 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1074919005902 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919005903 Q-loop/lid; other site
1074919005904 ABC transporter signature motif; other site
1074919005905 Walker B; other site
1074919005906 D-loop; other site
1074919005907 H-loop/switch region; other site
1074919005908 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
1074919005909 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919005910 Walker A/P-loop; other site
1074919005911 ATP binding site [chemical binding]; other site
1074919005912 Q-loop/lid; other site
1074919005913 ABC transporter signature motif; other site
1074919005914 Walker B; other site
1074919005915 D-loop; other site
1074919005916 H-loop/switch region; other site
1074919005917 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1074919005918 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1074919005919 alphaNTD homodimer interface [polypeptide binding]; other site
1074919005920 alphaNTD - beta interaction site [polypeptide binding]; other site
1074919005921 alphaNTD - beta' interaction site [polypeptide binding]; other site
1074919005922 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1074919005923 adenylate kinase; Reviewed; Region: adk; PRK00279
1074919005924 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1074919005925 AMP-binding site [chemical binding]; other site
1074919005926 ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1074919005927 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1074919005928 SecY translocase; Region: SecY; pfam00344
1074919005929 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
1074919005930 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1074919005931 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1074919005932 50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1074919005933 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1074919005934 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1074919005935 50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1074919005936 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1074919005937 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1074919005938 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1074919005939 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412
1074919005940 G-X-X-G motif; other site
1074919005941 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1074919005942 50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1074919005943 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1074919005944 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1074919005945 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1074919005946 50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1074919005947 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252
1074919005948 DNA topoisomerase III; Provisional; Region: PRK07726
1074919005949 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1074919005950 active site
1074919005951 putative interdomain interaction site [polypeptide binding]; other site
1074919005952 putative metal-binding site [ion binding]; other site
1074919005953 putative nucleotide binding site [chemical binding]; other site
1074919005954 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1074919005955 domain I; other site
1074919005956 DNA binding groove [nucleotide binding]
1074919005957 phosphate binding site [ion binding]; other site
1074919005958 domain II; other site
1074919005959 domain III; other site
1074919005960 nucleotide binding site [chemical binding]; other site
1074919005961 catalytic site [active]
1074919005962 domain IV; other site
1074919005963 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1074919005964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919005965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1074919005966 Coenzyme A binding pocket [chemical binding]; other site
1074919005967 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1074919005968 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1074919005969 Predicted permeases [General function prediction only]; Region: COG0679
1074919005970 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1074919005971 MMPL family; Region: MMPL; cl14618
1074919005972 MMPL family; Region: MMPL; cl14618
1074919005973 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1074919005974 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1074919005975 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1074919005976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919005977 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919005978 putative substrate translocation pore; other site
1074919005979 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1074919005980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919005981 FeS/SAM binding site; other site
1074919005982 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1074919005983 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1074919005984 GTP binding site; other site
1074919005985 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
1074919005986 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1074919005987 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1074919005988 dimer interface [polypeptide binding]; other site
1074919005989 putative functional site; other site
1074919005990 putative MPT binding site; other site
1074919005991 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1074919005992 trimer interface [polypeptide binding]; other site
1074919005993 dimer interface [polypeptide binding]; other site
1074919005994 putative active site [active]
1074919005995 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1074919005996 MPT binding site; other site
1074919005997 trimer interface [polypeptide binding]; other site
1074919005998 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1074919005999 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1074919006000 ATP binding site [chemical binding]; other site
1074919006001 substrate interface [chemical binding]; other site
1074919006002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006003 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1074919006004 Walker A/P-loop; other site
1074919006005 ATP binding site [chemical binding]; other site
1074919006006 Q-loop/lid; other site
1074919006007 ABC transporter signature motif; other site
1074919006008 Walker B; other site
1074919006009 D-loop; other site
1074919006010 H-loop/switch region; other site
1074919006011 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1074919006012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006013 dimer interface [polypeptide binding]; other site
1074919006014 conserved gate region; other site
1074919006015 putative PBP binding loops; other site
1074919006016 ABC-ATPase subunit interface; other site
1074919006017 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1074919006018 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1074919006019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006020 Coenzyme A binding pocket [chemical binding]; other site
1074919006021 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1074919006022 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
1074919006023 active site
1074919006024 dimerization interface [polypeptide binding]; other site
1074919006025 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1074919006026 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074919006027 intersubunit interface [polypeptide binding]; other site
1074919006028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1074919006029 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1074919006030 Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1074919006031 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
1074919006032 urease subunit alpha; Reviewed; Region: ureC; PRK13207
1074919006033 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1074919006034 subunit interactions [polypeptide binding]; other site
1074919006035 active site
1074919006036 flap region; other site
1074919006037 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1074919006038 UreF; Region: UreF; pfam01730
1074919006039 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1074919006040 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1074919006041 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919006042 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919006043 Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919006044 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1074919006045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919006046 Surface antigen [General function prediction only]; Region: COG3942
1074919006047 CHAP domain; Region: CHAP; pfam05257
1074919006048 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1074919006049 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
1074919006050 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1074919006051 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1074919006052 Surface antigen [General function prediction only]; Region: COG3942
1074919006053 CHAP domain; Region: CHAP; pfam05257
1074919006054 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1074919006055 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1074919006056 putative ligand binding site [chemical binding]; other site
1074919006057 putative NAD binding site [chemical binding]; other site
1074919006058 catalytic site [active]
1074919006059 hypothetical protein; Provisional; Region: PRK06753
1074919006060 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1074919006061 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
1074919006062 Lysozyme subfamily 2; Region: LYZ2; smart00047
1074919006063 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1074919006064 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1074919006065 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1074919006066 4Fe-4S binding domain; Region: Fer4; pfam00037
1074919006067 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1074919006068 [4Fe-4S] binding site [ion binding]; other site
1074919006069 molybdopterin cofactor binding site; other site
1074919006070 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1074919006071 molybdopterin cofactor binding site; other site
1074919006072 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1074919006073 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1074919006074 active site
1074919006075 Predicted transcriptional regulator [Transcription]; Region: COG2378
1074919006076 HTH domain; Region: HTH_11; pfam08279
1074919006077 CAAX protease self-immunity; Region: Abi; pfam02517
1074919006078 Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919006079 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1074919006080 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1074919006081 putative active site [active]
1074919006082 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1074919006083 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1074919006084 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1074919006085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919006086 active site
1074919006087 motif I; other site
1074919006088 motif II; other site
1074919006089 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1074919006090 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1074919006091 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919006092 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919006093 active site turn [active]
1074919006094 phosphorylation site [posttranslational modification]
1074919006095 Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1074919006096 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1074919006097 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1074919006098 putative active site [active]
1074919006099 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1074919006100 putative hydrophobic ligand binding site [chemical binding]; other site
1074919006101 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1074919006102 oxidoreductase; Provisional; Region: PRK07985
1074919006103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919006104 NAD(P) binding site [chemical binding]; other site
1074919006105 active site
1074919006106 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1074919006107 amidohydrolase; Region: amidohydrolases; TIGR01891
1074919006108 metal binding site [ion binding]; metal-binding site
1074919006109 dimer interface [polypeptide binding]; other site
1074919006110 imidazolonepropionase; Validated; Region: PRK09356
1074919006111 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1074919006112 active site
1074919006113 urocanate hydratase; Provisional; Region: PRK05414
1074919006114 Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919006115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919006116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1074919006117 dimerization interface [polypeptide binding]; other site
1074919006118 fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1074919006119 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
1074919006120 putative active site [active]
1074919006121 putative Mg binding site [ion binding]; other site
1074919006122 formimidoylglutamase; Provisional; Region: PRK13775
1074919006123 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1074919006124 putative active site [active]
1074919006125 putative metal binding site [ion binding]; other site
1074919006126 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1074919006127 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1074919006128 tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074919006129 active site
1074919006130 dimer interface [polypeptide binding]; other site
1074919006131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1074919006132 MOSC domain; Region: MOSC; pfam03473
1074919006133 3-alpha domain; Region: 3-alpha; pfam03475
1074919006134 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1074919006135 active site
1074919006136 catalytic residues [active]
1074919006137 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1074919006138 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1074919006139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006140 Walker A/P-loop; other site
1074919006141 ATP binding site [chemical binding]; other site
1074919006142 Q-loop/lid; other site
1074919006143 ABC transporter signature motif; other site
1074919006144 Walker B; other site
1074919006145 D-loop; other site
1074919006146 H-loop/switch region; other site
1074919006147 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1074919006148 Predicted membrane protein [Function unknown]; Region: COG3152
1074919006149 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1074919006150 active site
1074919006151 DNA binding site [nucleotide binding]
1074919006152 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
1074919006153 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1074919006154 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1074919006155 homotetramer interface [polypeptide binding]; other site
1074919006156 FMN binding site [chemical binding]; other site
1074919006157 homodimer contacts [polypeptide binding]; other site
1074919006158 putative active site [active]
1074919006159 putative substrate binding site [chemical binding]; other site
1074919006160 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1074919006161 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1074919006162 oligomer interface [polypeptide binding]; other site
1074919006163 metal binding site [ion binding]; metal-binding site
1074919006164 metal binding site [ion binding]; metal-binding site
1074919006165 putative Cl binding site [ion binding]; other site
1074919006166 aspartate ring; other site
1074919006167 basic sphincter; other site
1074919006168 hydrophobic gate; other site
1074919006169 periplasmic entrance; other site
1074919006170 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1074919006171 active site
1074919006172 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1074919006173 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1074919006174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006175 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1074919006176 putative substrate translocation pore; other site
1074919006177 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1074919006178 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1074919006179 HlyD family secretion protein; Region: HlyD_3; pfam13437
1074919006180 lipoyl-biotinyl attachment site [posttranslational modification]; other site
1074919006181 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1074919006182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006183 putative substrate translocation pore; other site
1074919006184 Predicted membrane protein [Function unknown]; Region: COG4640
1074919006185 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1074919006186 Uncharacterized conserved protein [Function unknown]; Region: COG1434
1074919006187 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1074919006188 putative active site [active]
1074919006189 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919006190 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919006191 Walker A/P-loop; other site
1074919006192 ATP binding site [chemical binding]; other site
1074919006193 Q-loop/lid; other site
1074919006194 ABC transporter signature motif; other site
1074919006195 Walker B; other site
1074919006196 D-loop; other site
1074919006197 H-loop/switch region; other site
1074919006198 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1074919006199 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074919006200 FtsX-like permease family; Region: FtsX; pfam02687
1074919006201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919006202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919006203 active site
1074919006204 phosphorylation site [posttranslational modification]
1074919006205 intermolecular recognition site; other site
1074919006206 dimerization interface [polypeptide binding]; other site
1074919006207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919006208 DNA binding site [nucleotide binding]
1074919006209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919006210 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1074919006211 dimerization interface [polypeptide binding]; other site
1074919006212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1074919006213 dimer interface [polypeptide binding]; other site
1074919006214 phosphorylation site [posttranslational modification]
1074919006215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919006216 ATP binding site [chemical binding]; other site
1074919006217 Mg2+ binding site [ion binding]; other site
1074919006218 G-X-G motif; other site
1074919006219 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1074919006220 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
1074919006221 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1074919006222 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1074919006223 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1074919006224 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919006225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006226 Coenzyme A binding pocket [chemical binding]; other site
1074919006227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919006228 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1074919006229 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1074919006230 NAD(P) binding site [chemical binding]; other site
1074919006231 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1074919006232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919006233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919006234 Predicted membrane protein [Function unknown]; Region: COG1511
1074919006235 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
1074919006236 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1074919006237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919006238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919006239 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1074919006240 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1074919006241 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1074919006242 Cl binding site [ion binding]; other site
1074919006243 oligomer interface [polypeptide binding]; other site
1074919006244 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1074919006245 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919006246 active site turn [active]
1074919006247 phosphorylation site [posttranslational modification]
1074919006248 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919006249 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1074919006250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1074919006251 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1074919006252 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1074919006253 Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1074919006254 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1074919006255 Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919006256 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1074919006257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006258 putative substrate translocation pore; other site
1074919006259 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
1074919006260 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1074919006261 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1074919006262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919006263 active site
1074919006264 phosphorylation site [posttranslational modification]
1074919006265 intermolecular recognition site; other site
1074919006266 dimerization interface [polypeptide binding]; other site
1074919006267 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1074919006268 DNA binding residues [nucleotide binding]
1074919006269 dimerization interface [polypeptide binding]; other site
1074919006270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1074919006271 Histidine kinase; Region: HisKA_3; pfam07730
1074919006272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919006273 ATP binding site [chemical binding]; other site
1074919006274 Mg2+ binding site [ion binding]; other site
1074919006275 G-X-G motif; other site
1074919006276 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1074919006277 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1074919006278 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1074919006279 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1074919006280 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1074919006281 [4Fe-4S] binding site [ion binding]; other site
1074919006282 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1074919006283 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1074919006284 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1074919006285 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1074919006286 molybdopterin cofactor binding site; other site
1074919006287 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1074919006288 active site
1074919006289 SAM binding site [chemical binding]; other site
1074919006290 homodimer interface [polypeptide binding]; other site
1074919006291 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1074919006292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1074919006293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1074919006294 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1074919006295 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1074919006296 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1074919006297 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1074919006298 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1074919006299 putative active site [active]
1074919006300 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1074919006301 active site
1074919006302 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1074919006303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006304 Coenzyme A binding pocket [chemical binding]; other site
1074919006305 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1074919006306 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1074919006307 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1074919006308 putative hydrophobic ligand binding site [chemical binding]; other site
1074919006309 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1074919006310 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1074919006311 intersubunit interface [polypeptide binding]; other site
1074919006312 YodA lipocalin-like domain; Region: YodA; pfam09223
1074919006313 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1074919006314 Thioredoxin; Region: Thioredoxin_4; pfam13462
1074919006315 FemAB family; Region: FemAB; pfam02388
1074919006316 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1074919006317 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1074919006318 Walker A/P-loop; other site
1074919006319 ATP binding site [chemical binding]; other site
1074919006320 Q-loop/lid; other site
1074919006321 ABC transporter signature motif; other site
1074919006322 Walker B; other site
1074919006323 D-loop; other site
1074919006324 H-loop/switch region; other site
1074919006325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006326 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1074919006327 dimer interface [polypeptide binding]; other site
1074919006328 conserved gate region; other site
1074919006329 putative PBP binding loops; other site
1074919006330 ABC-ATPase subunit interface; other site
1074919006331 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1074919006332 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1074919006333 substrate binding pocket [chemical binding]; other site
1074919006334 membrane-bound complex binding site; other site
1074919006335 hinge residues; other site
1074919006336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006337 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919006338 putative substrate translocation pore; other site
1074919006339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006340 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074919006341 catalytic core [active]
1074919006342 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1074919006343 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1074919006344 cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1074919006345 B domain; Region: B; pfam02216
1074919006346 B domain; Region: B; pfam02216
1074919006347 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
1074919006348 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1074919006349 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1074919006350 beta-channel forming cytolysin; Region: hlyII; TIGR01002
1074919006351 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
1074919006352 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1074919006353 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1074919006354 catalytic residue [active]
1074919006355 biotin synthase; Validated; Region: PRK06256
1074919006356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1074919006357 FeS/SAM binding site; other site
1074919006358 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1074919006359 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919006360 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1074919006361 inhibitor-cofactor binding pocket; inhibition site
1074919006362 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919006363 catalytic residue [active]
1074919006364 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1074919006365 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1074919006366 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1074919006367 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919006368 Walker A/P-loop; other site
1074919006369 ATP binding site [chemical binding]; other site
1074919006370 Q-loop/lid; other site
1074919006371 ABC transporter signature motif; other site
1074919006372 Walker B; other site
1074919006373 D-loop; other site
1074919006374 H-loop/switch region; other site
1074919006375 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1074919006376 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1074919006377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006378 Walker A/P-loop; other site
1074919006379 ATP binding site [chemical binding]; other site
1074919006380 Q-loop/lid; other site
1074919006381 ABC transporter signature motif; other site
1074919006382 Walker B; other site
1074919006383 D-loop; other site
1074919006384 H-loop/switch region; other site
1074919006385 glycerate kinase; Region: TIGR00045
1074919006386 hypothetical protein; Provisional; Region: PRK11281
1074919006387 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1074919006388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006389 putative substrate translocation pore; other site
1074919006390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1074919006391 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1074919006392 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1074919006393 putative phosphoesterase; Region: acc_ester; TIGR03729
1074919006394 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1074919006395 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1074919006396 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1074919006397 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1074919006398 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1074919006399 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1074919006400 Beta-lactamase; Region: Beta-lactamase; pfam00144
1074919006401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1074919006402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919006403 NAD(P) binding site [chemical binding]; other site
1074919006404 active site
1074919006405 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1074919006406 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1074919006407 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1074919006408 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919006409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006410 putative substrate translocation pore; other site
1074919006411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006412 dimer interface [polypeptide binding]; other site
1074919006413 conserved gate region; other site
1074919006414 ABC-ATPase subunit interface; other site
1074919006415 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1074919006416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006417 dimer interface [polypeptide binding]; other site
1074919006418 conserved gate region; other site
1074919006419 putative PBP binding loops; other site
1074919006420 ABC-ATPase subunit interface; other site
1074919006421 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1074919006422 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1074919006423 Walker A/P-loop; other site
1074919006424 ATP binding site [chemical binding]; other site
1074919006425 Q-loop/lid; other site
1074919006426 ABC transporter signature motif; other site
1074919006427 Walker B; other site
1074919006428 D-loop; other site
1074919006429 H-loop/switch region; other site
1074919006430 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1074919006431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1074919006432 Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1074919006433 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1074919006434 amino acid transporter; Region: 2A0306; TIGR00909
1074919006435 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1074919006436 substrate binding pocket [chemical binding]; other site
1074919006437 catalytic triad [active]
1074919006438 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1074919006439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006440 putative substrate translocation pore; other site
1074919006441 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1074919006442 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1074919006443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006444 Walker A/P-loop; other site
1074919006445 ATP binding site [chemical binding]; other site
1074919006446 Q-loop/lid; other site
1074919006447 ABC transporter signature motif; other site
1074919006448 Walker B; other site
1074919006449 D-loop; other site
1074919006450 H-loop/switch region; other site
1074919006451 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1074919006452 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1074919006453 oligomer interface [polypeptide binding]; other site
1074919006454 active site
1074919006455 metal binding site [ion binding]; metal-binding site
1074919006456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
1074919006457 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1074919006458 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1074919006459 active site
1074919006460 FMN binding site [chemical binding]; other site
1074919006461 substrate binding site [chemical binding]; other site
1074919006462 3Fe-4S cluster binding site [ion binding]; other site
1074919006463 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1074919006464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006465 Major Facilitator Superfamily; Region: MFS_1; pfam07690
1074919006466 putative substrate translocation pore; other site
1074919006467 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1074919006468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919006469 Walker A/P-loop; other site
1074919006470 ATP binding site [chemical binding]; other site
1074919006471 Q-loop/lid; other site
1074919006472 ABC transporter signature motif; other site
1074919006473 Walker B; other site
1074919006474 D-loop; other site
1074919006475 H-loop/switch region; other site
1074919006476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1074919006477 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1074919006478 Walker A/P-loop; other site
1074919006479 ATP binding site [chemical binding]; other site
1074919006480 Q-loop/lid; other site
1074919006481 ABC transporter signature motif; other site
1074919006482 Walker B; other site
1074919006483 D-loop; other site
1074919006484 H-loop/switch region; other site
1074919006485 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1074919006486 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1074919006487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006488 dimer interface [polypeptide binding]; other site
1074919006489 conserved gate region; other site
1074919006490 putative PBP binding loops; other site
1074919006491 ABC-ATPase subunit interface; other site
1074919006492 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1074919006493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1074919006494 dimer interface [polypeptide binding]; other site
1074919006495 conserved gate region; other site
1074919006496 putative PBP binding loops; other site
1074919006497 ABC-ATPase subunit interface; other site
1074919006498 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1074919006499 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1074919006500 substrate binding site [chemical binding]; other site
1074919006501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
1074919006502 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
1074919006503 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1074919006504 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1074919006505 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1074919006506 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1074919006507 short chain dehydrogenase; Validated; Region: PRK08589
1074919006508 classical (c) SDRs; Region: SDR_c; cd05233
1074919006509 NAD(P) binding site [chemical binding]; other site
1074919006510 active site
1074919006511 AbgT putative transporter family; Region: ABG_transport; pfam03806
1074919006512 Uncharacterized conserved protein [Function unknown]; Region: COG2128
1074919006513 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1074919006514 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1074919006515 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1074919006516 classical (c) SDRs; Region: SDR_c; cd05233
1074919006517 NAD(P) binding site [chemical binding]; other site
1074919006518 active site
1074919006519 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919006520 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919006521 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919006522 Protein of unknown function, DUF576; Region: DUF576; pfam04507
1074919006523 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1074919006524 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
1074919006525 PLD-like domain; Region: PLDc_2; pfam13091
1074919006526 putative homodimer interface [polypeptide binding]; other site
1074919006527 putative active site [active]
1074919006528 catalytic site [active]
1074919006529 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1074919006530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1074919006531 ATP binding site [chemical binding]; other site
1074919006532 putative Mg++ binding site [ion binding]; other site
1074919006533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1074919006534 nucleotide binding region [chemical binding]; other site
1074919006535 ATP-binding site [chemical binding]; other site
1074919006536 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1074919006537 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1074919006538 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1074919006539 active site
1074919006540 substrate binding site [chemical binding]; other site
1074919006541 metal binding site [ion binding]; metal-binding site
1074919006542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006543 putative substrate translocation pore; other site
1074919006544 H+ Antiporter protein; Region: 2A0121; TIGR00900
1074919006545 G5 domain; Region: G5; pfam07501
1074919006546 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1074919006547 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919006548 legume lectins; Region: lectin_L-type; cl14058
1074919006549 homotetramer interaction site [polypeptide binding]; other site
1074919006550 carbohydrate binding site [chemical binding]; other site
1074919006551 metal binding site [ion binding]; metal-binding site
1074919006552 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919006553 Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919006554 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
1074919006555 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1074919006556 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1074919006557 active site
1074919006558 tetramer interface; other site
1074919006559 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919006560 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919006561 Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1074919006562 GntP family permease; Region: GntP_permease; pfam02447
1074919006563 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1074919006564 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1074919006565 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1074919006566 N- and C-terminal domain interface [polypeptide binding]; other site
1074919006567 active site
1074919006568 catalytic site [active]
1074919006569 metal binding site [ion binding]; metal-binding site
1074919006570 carbohydrate binding site [chemical binding]; other site
1074919006571 ATP binding site [chemical binding]; other site
1074919006572 Transcriptional regulators [Transcription]; Region: GntR; COG1802
1074919006573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1074919006574 DNA-binding site [nucleotide binding]; DNA binding site
1074919006575 FCD domain; Region: FCD; pfam07729
1074919006576 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1074919006577 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1074919006578 DNA binding residues [nucleotide binding]
1074919006579 dimer interface [polypeptide binding]; other site
1074919006580 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1074919006581 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1074919006582 synthetase active site [active]
1074919006583 NTP binding site [chemical binding]; other site
1074919006584 metal binding site [ion binding]; metal-binding site
1074919006585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1074919006586 Predicted membrane protein [Function unknown]; Region: COG1289
1074919006587 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1074919006588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1074919006589 D-galactonate transporter; Region: 2A0114; TIGR00893
1074919006590 putative substrate translocation pore; other site
1074919006591 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1074919006592 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1074919006593 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1074919006594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006595 Walker A/P-loop; other site
1074919006596 ATP binding site [chemical binding]; other site
1074919006597 Q-loop/lid; other site
1074919006598 ABC transporter signature motif; other site
1074919006599 Walker B; other site
1074919006600 D-loop; other site
1074919006601 H-loop/switch region; other site
1074919006602 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1074919006603 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
1074919006604 Uncharacterized membrane protein [Function unknown]; Region: COG3949
1074919006605 Predicted esterase [General function prediction only]; Region: COG0400
1074919006606 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1074919006607 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1074919006608 Zn binding site [ion binding]; other site
1074919006609 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1074919006610 Zn binding site [ion binding]; other site
1074919006611 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1074919006612 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1074919006613 putative metal binding site [ion binding]; other site
1074919006614 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1074919006615 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1074919006616 dimer interface [polypeptide binding]; other site
1074919006617 FMN binding site [chemical binding]; other site
1074919006618 D-lactate dehydrogenase; Validated; Region: PRK08605
1074919006619 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1074919006620 homodimer interface [polypeptide binding]; other site
1074919006621 ligand binding site [chemical binding]; other site
1074919006622 NAD binding site [chemical binding]; other site
1074919006623 catalytic site [active]
1074919006624 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1074919006625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1074919006626 active site
1074919006627 motif I; other site
1074919006628 motif II; other site
1074919006629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1074919006630 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919006631 Walker A/P-loop; other site
1074919006632 ATP binding site [chemical binding]; other site
1074919006633 Q-loop/lid; other site
1074919006634 ABC transporter signature motif; other site
1074919006635 Walker B; other site
1074919006636 D-loop; other site
1074919006637 H-loop/switch region; other site
1074919006638 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1074919006639 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
1074919006640 active site
1074919006641 catalytic site [active]
1074919006642 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1074919006643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006644 Coenzyme A binding pocket [chemical binding]; other site
1074919006645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1074919006646 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1074919006647 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1074919006648 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1074919006649 Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1074919006650 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1074919006651 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1074919006652 EamA-like transporter family; Region: EamA; pfam00892
1074919006653 EamA-like transporter family; Region: EamA; pfam00892
1074919006654 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1074919006655 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1074919006656 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1074919006657 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1074919006658 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1074919006659 active site turn [active]
1074919006660 phosphorylation site [posttranslational modification]
1074919006661 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1074919006662 HPr interaction site; other site
1074919006663 glycerol kinase (GK) interaction site [polypeptide binding]; other site
1074919006664 active site
1074919006665 phosphorylation site [posttranslational modification]
1074919006666 pyruvate oxidase; Provisional; Region: PRK08611
1074919006667 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1074919006668 PYR/PP interface [polypeptide binding]; other site
1074919006669 tetramer interface [polypeptide binding]; other site
1074919006670 dimer interface [polypeptide binding]; other site
1074919006671 TPP binding site [chemical binding]; other site
1074919006672 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1074919006673 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1074919006674 TPP-binding site [chemical binding]; other site
1074919006675 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1074919006676 Transcriptional regulator [Transcription]; Region: LysR; COG0583
1074919006677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1074919006678 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1074919006679 putative dimerization interface [polypeptide binding]; other site
1074919006680 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1074919006681 homodimer interface [polypeptide binding]; other site
1074919006682 catalytic residues [active]
1074919006683 NAD binding site [chemical binding]; other site
1074919006684 substrate binding pocket [chemical binding]; other site
1074919006685 flexible flap; other site
1074919006686 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1074919006687 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1074919006688 dimer interface [polypeptide binding]; other site
1074919006689 active site
1074919006690 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1074919006691 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1074919006692 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1074919006693 DNA binding site [nucleotide binding]
1074919006694 active site
1074919006695 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1074919006696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919006697 Walker A motif; other site
1074919006698 ATP binding site [chemical binding]; other site
1074919006699 Walker B motif; other site
1074919006700 arginine finger; other site
1074919006701 UvrB/uvrC motif; Region: UVR; pfam02151
1074919006702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1074919006703 Walker A motif; other site
1074919006704 ATP binding site [chemical binding]; other site
1074919006705 Walker B motif; other site
1074919006706 arginine finger; other site
1074919006707 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1074919006708 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1074919006709 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1074919006710 G1 box; other site
1074919006711 GTP/Mg2+ binding site [chemical binding]; other site
1074919006712 Switch I region; other site
1074919006713 G2 box; other site
1074919006714 G3 box; other site
1074919006715 Switch II region; other site
1074919006716 G4 box; other site
1074919006717 G5 box; other site
1074919006718 Nucleoside recognition; Region: Gate; pfam07670
1074919006719 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1074919006720 Nucleoside recognition; Region: Gate; pfam07670
1074919006721 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1074919006722 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080
1074919006723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919006724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919006725 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1074919006726 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1074919006727 Glutamate binding site [chemical binding]; other site
1074919006728 homodimer interface [polypeptide binding]; other site
1074919006729 NAD binding site [chemical binding]; other site
1074919006730 catalytic residues [active]
1074919006731 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
1074919006732 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1074919006733 active site
1074919006734 substrate binding site [chemical binding]; other site
1074919006735 trimer interface [polypeptide binding]; other site
1074919006736 CoA binding site [chemical binding]; other site
1074919006737 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1074919006738 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1074919006739 metal-binding site [ion binding]
1074919006740 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1074919006741 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1074919006742 metal-binding site [ion binding]
1074919006743 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1074919006744 Soluble P-type ATPase [General function prediction only]; Region: COG4087
1074919006745 D-lactate dehydrogenase; Validated; Region: PRK08605
1074919006746 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1074919006747 homodimer interface [polypeptide binding]; other site
1074919006748 ligand binding site [chemical binding]; other site
1074919006749 NAD binding site [chemical binding]; other site
1074919006750 catalytic site [active]
1074919006751 transaminase; Reviewed; Region: PRK08068
1074919006752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919006753 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919006754 homodimer interface [polypeptide binding]; other site
1074919006755 catalytic residue [active]
1074919006756 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1074919006757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074919006758 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1074919006759 active site lid residues [active]
1074919006760 substrate binding pocket [chemical binding]; other site
1074919006761 catalytic residues [active]
1074919006762 substrate-Mg2+ binding site; other site
1074919006763 aspartate-rich region 1; other site
1074919006764 aspartate-rich region 2; other site
1074919006765 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1074919006766 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1074919006767 active site
1074919006768 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1074919006769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1074919006770 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237
1074919006771 Surface antigen [General function prediction only]; Region: COG3942
1074919006772 CHAP domain; Region: CHAP; pfam05257
1074919006773 Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1074919006774 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1074919006775 catalytic triad [active]
1074919006776 catalytic triad [active]
1074919006777 oxyanion hole [active]
1074919006778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919006779 Coenzyme A binding pocket [chemical binding]; other site
1074919006780 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1074919006781 catalytic residue [active]
1074919006782 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1074919006783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919006784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919006785 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1074919006786 NmrA-like family; Region: NmrA; pfam05368
1074919006787 NADP binding site [chemical binding]; other site
1074919006788 active site
1074919006789 regulatory binding site [polypeptide binding]; other site
1074919006790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919006791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919006792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1074919006793 acetoacetyl-CoA reductase; Provisional; Region: PRK12824
1074919006794 NAD(P) binding site [chemical binding]; other site
1074919006795 active site
1074919006796 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1074919006797 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1074919006798 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1074919006799 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1074919006800 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1074919006801 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1074919006802 Nucleoside recognition; Region: Gate; pfam07670
1074919006803 Nucleoside recognition; Region: Gate; pfam07670
1074919006804 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1074919006805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1074919006806 Phosphotransferase enzyme family; Region: APH; pfam01636
1074919006807 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1074919006808 active site
1074919006809 ATP binding site [chemical binding]; other site
1074919006810 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1074919006811 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1074919006812 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1074919006813 quinone interaction residues [chemical binding]; other site
1074919006814 active site
1074919006815 catalytic residues [active]
1074919006816 FMN binding site [chemical binding]; other site
1074919006817 substrate binding site [chemical binding]; other site
1074919006818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1074919006819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919006820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919006821 Predicted acyl esterases [General function prediction only]; Region: COG2936
1074919006822 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1074919006823 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919006824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919006825 S-adenosylmethionine binding site [chemical binding]; other site
1074919006826 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1074919006827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919006828 S-adenosylmethionine binding site [chemical binding]; other site
1074919006829 aminoglycoside resistance protein; Provisional; Region: PRK13746
1074919006830 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1074919006831 active site
1074919006832 NTP binding site [chemical binding]; other site
1074919006833 metal binding triad [ion binding]; metal-binding site
1074919006834 antibiotic binding site [chemical binding]; other site
1074919006835 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1074919006836 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1074919006837 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1074919006838 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1074919006839 active site
1074919006840 DNA binding site [nucleotide binding]
1074919006841 Int/Topo IB signature motif; other site
1074919006842 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235
1074919006843 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1074919006844 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
1074919006845 Int/Topo IB signature motif; other site
1074919006846 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1074919006847 pantoate--beta-alanine ligase; Region: panC; TIGR00018
1074919006848 Pantoate-beta-alanine ligase; Region: PanC; cd00560
1074919006849 active site
1074919006850 ATP-binding site [chemical binding]; other site
1074919006851 pantoate-binding site; other site
1074919006852 HXXH motif; other site
1074919006853 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1074919006854 active site
1074919006855 oligomerization interface [polypeptide binding]; other site
1074919006856 metal binding site [ion binding]; metal-binding site
1074919006857 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1074919006858 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1074919006859 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1074919006860 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1074919006861 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1074919006862 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1074919006863 tetramer (dimer of dimers) interface [polypeptide binding]; other site
1074919006864 NAD binding site [chemical binding]; other site
1074919006865 dimer interface [polypeptide binding]; other site
1074919006866 substrate binding site [chemical binding]; other site
1074919006867 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1074919006868 amino acid transporter; Region: 2A0306; TIGR00909
1074919006869 C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1074919006870 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
1074919006871 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1074919006872 inhibitor-cofactor binding pocket; inhibition site
1074919006873 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919006874 catalytic residue [active]
1074919006875 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
1074919006876 catalytic residue [active]
1074919006877 malate:quinone oxidoreductase; Reviewed; Region: PRK13339
1074919006878 Predicted dehydrogenase [General function prediction only]; Region: COG0579
1074919006879 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1074919006880 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1074919006881 acyl-activating enzyme (AAE) consensus motif; other site
1074919006882 AMP binding site [chemical binding]; other site
1074919006883 active site
1074919006884 CoA binding site [chemical binding]; other site
1074919006885 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1074919006886 choline dehydrogenase; Validated; Region: PRK02106
1074919006887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1074919006888 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1074919006889 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1074919006890 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1074919006891 tetramerization interface [polypeptide binding]; other site
1074919006892 NAD(P) binding site [chemical binding]; other site
1074919006893 catalytic residues [active]
1074919006894 Predicted transcriptional regulators [Transcription]; Region: COG1510
1074919006895 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1074919006896 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1074919006897 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1074919006898 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
1074919006899 Class III ribonucleotide reductase; Region: RNR_III; cd01675
1074919006900 effector binding site; other site
1074919006901 active site
1074919006902 Zn binding site [ion binding]; other site
1074919006903 glycine loop; other site
1074919006904 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1074919006905 Citrate transporter; Region: CitMHS; pfam03600
1074919006906 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
1074919006907 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1074919006908 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1074919006909 Flavodoxin; Region: Flavodoxin_1; pfam00258
1074919006910 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1074919006911 FAD binding pocket [chemical binding]; other site
1074919006912 FAD binding motif [chemical binding]; other site
1074919006913 catalytic residues [active]
1074919006914 NAD binding pocket [chemical binding]; other site
1074919006915 phosphate binding motif [ion binding]; other site
1074919006916 beta-alpha-beta structure motif; other site
1074919006917 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1074919006918 catalytic residues [active]
1074919006919 dimer interface [polypeptide binding]; other site
1074919006920 FtsX-like permease family; Region: FtsX; pfam02687
1074919006921 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919006922 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919006923 Walker A/P-loop; other site
1074919006924 ATP binding site [chemical binding]; other site
1074919006925 Q-loop/lid; other site
1074919006926 ABC transporter signature motif; other site
1074919006927 Walker B; other site
1074919006928 D-loop; other site
1074919006929 H-loop/switch region; other site
1074919006930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1074919006931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1074919006932 ATP binding site [chemical binding]; other site
1074919006933 Mg2+ binding site [ion binding]; other site
1074919006934 G-X-G motif; other site
1074919006935 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1074919006936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1074919006937 active site
1074919006938 phosphorylation site [posttranslational modification]
1074919006939 intermolecular recognition site; other site
1074919006940 dimerization interface [polypeptide binding]; other site
1074919006941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1074919006942 DNA binding site [nucleotide binding]
1074919006943 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1074919006944 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1074919006945 dimer interface [polypeptide binding]; other site
1074919006946 active site
1074919006947 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1074919006948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1074919006949 Transcriptional regulators [Transcription]; Region: MarR; COG1846
1074919006950 Predicted esterase [General function prediction only]; Region: COG0627
1074919006951 S-formylglutathione hydrolase; Region: PLN02442
1074919006952 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1074919006953 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
1074919006954 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1074919006955 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
1074919006956 ligand binding site [chemical binding]; other site
1074919006957 flexible hinge region; other site
1074919006958 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1074919006959 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1074919006960 putative substrate binding site [chemical binding]; other site
1074919006961 nucleotide binding site [chemical binding]; other site
1074919006962 nucleotide binding site [chemical binding]; other site
1074919006963 homodimer interface [polypeptide binding]; other site
1074919006964 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1074919006965 ornithine carbamoyltransferase; Validated; Region: PRK02102
1074919006966 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1074919006967 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1074919006968 arginine deiminase; Provisional; Region: PRK01388
1074919006969 Arginine repressor [Transcription]; Region: ArgR; COG1438
1074919006970 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1074919006971 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1074919006972 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1074919006973 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1074919006974 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1074919006975 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1074919006976 active site
1074919006977 Zn binding site [ion binding]; other site
1074919006978 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1074919006979 HTH domain; Region: HTH_11; pfam08279
1074919006980 PRD domain; Region: PRD; pfam00874
1074919006981 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1074919006982 active site
1074919006983 P-loop; other site
1074919006984 phosphorylation site [posttranslational modification]
1074919006985 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919006986 active site
1074919006987 phosphorylation site [posttranslational modification]
1074919006988 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404
1074919006989 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1074919006990 active site
1074919006991 P-loop; other site
1074919006992 phosphorylation site [posttranslational modification]
1074919006993 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1074919006994 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1074919006995 active site
1074919006996 phosphorylation site [posttranslational modification]
1074919006997 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1074919006998 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1074919006999 Predicted membrane protein [Function unknown]; Region: COG1511
1074919007000 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
1074919007001 Retro-transposon transporting motif; Region: Nup_retrotrp_bd; pfam10599
1074919007002 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1074919007003 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
1074919007004 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1074919007005 CHAP domain; Region: CHAP; pfam05257
1074919007006 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1074919007007 catalytic triad [active]
1074919007008 conserved cis-peptide bond; other site
1074919007009 rad50; Region: rad50; TIGR00606
1074919007010 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1074919007011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1074919007012 accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1074919007013 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949
1074919007014 accessory Sec system translocase SecA2; Region: secA2; TIGR03714
1074919007015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1074919007016 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1074919007017 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1074919007018 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1074919007019 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1074919007020 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1074919007021 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
1074919007022 SecY translocase; Region: SecY; pfam00344
1074919007023 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1074919007024 legume lectins; Region: lectin_L-type; cd01951
1074919007025 homotetramer interaction site [polypeptide binding]; other site
1074919007026 carbohydrate binding site [chemical binding]; other site
1074919007027 metal binding site [ion binding]; metal-binding site
1074919007028 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1074919007029 Putative Ig domain; Region: He_PIG; pfam05345
1074919007030 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1074919007031 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1074919007032 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1074919007033 methionine sulfoxide reductase A; Provisional; Region: PRK05528
1074919007034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1074919007035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1074919007036 Coenzyme A binding pocket [chemical binding]; other site
1074919007037 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1074919007038 capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1074919007039 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1074919007040 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1074919007041 Chain length determinant protein; Region: Wzz; cl15801
1074919007042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1074919007043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1074919007044 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
1074919007045 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423
1074919007046 DXD motif; other site
1074919007047 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
1074919007048 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1074919007049 Acyltransferase family; Region: Acyl_transf_3; pfam01757
1074919007050 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1074919007051 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1074919007052 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1074919007053 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1074919007054 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1074919007055 metal binding site [ion binding]; metal-binding site
1074919007056 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1074919007057 glutamase interaction surface [polypeptide binding]; other site
1074919007058 substrate binding site [chemical binding]; other site
1074919007059 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1074919007060 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1074919007061 catalytic residues [active]
1074919007062 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1074919007063 putative active site [active]
1074919007064 oxyanion strand; other site
1074919007065 catalytic triad [active]
1074919007066 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1074919007067 putative active site pocket [active]
1074919007068 4-fold oligomerization interface [polypeptide binding]; other site
1074919007069 metal binding residues [ion binding]; metal-binding site
1074919007070 3-fold/trimer interface [polypeptide binding]; other site
1074919007071 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1074919007072 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1074919007073 pyridoxal 5'-phosphate binding site [chemical binding]; other site
1074919007074 homodimer interface [polypeptide binding]; other site
1074919007075 catalytic residue [active]
1074919007076 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1074919007077 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1074919007078 NAD binding site [chemical binding]; other site
1074919007079 dimerization interface [polypeptide binding]; other site
1074919007080 product binding site; other site
1074919007081 substrate binding site [chemical binding]; other site
1074919007082 zinc binding site [ion binding]; other site
1074919007083 catalytic residues [active]
1074919007084 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
1074919007085 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1074919007086 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
1074919007087 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
1074919007088 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1074919007089 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1074919007090 putative active site [active]
1074919007091 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1074919007092 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1074919007093 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919007094 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919007095 Walker A/P-loop; other site
1074919007096 ATP binding site [chemical binding]; other site
1074919007097 Q-loop/lid; other site
1074919007098 ABC transporter signature motif; other site
1074919007099 Walker B; other site
1074919007100 D-loop; other site
1074919007101 H-loop/switch region; other site
1074919007102 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1074919007103 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1074919007104 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1074919007105 Walker A/P-loop; other site
1074919007106 ATP binding site [chemical binding]; other site
1074919007107 Q-loop/lid; other site
1074919007108 ABC transporter signature motif; other site
1074919007109 Walker B; other site
1074919007110 H-loop/switch region; other site
1074919007111 hypothetical protein; Provisional; Region: PRK13661
1074919007112 Uncharacterized conserved protein [Function unknown]; Region: COG1912
1074919007113 Uncharacterized conserved protein [Function unknown]; Region: COG2353
1074919007114 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1074919007115 Strictosidine synthase; Region: Str_synth; cl19733
1074919007116 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1074919007117 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1074919007118 active site residue [active]
1074919007119 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1074919007120 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1074919007121 putative substrate binding pocket [chemical binding]; other site
1074919007122 AC domain interface; other site
1074919007123 catalytic triad [active]
1074919007124 AB domain interface; other site
1074919007125 interchain disulfide; other site
1074919007126 DinB superfamily; Region: DinB_2; pfam12867
1074919007127 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1074919007128 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1074919007129 transmembrane helices; other site
1074919007130 Predicted permeases [General function prediction only]; Region: RarD; COG2962
1074919007131 Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1074919007132 hypothetical protein; Provisional; Region: PRK07758
1074919007133 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1074919007134 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1074919007135 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1074919007136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1074919007137 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1074919007138 Walker A/P-loop; other site
1074919007139 ATP binding site [chemical binding]; other site
1074919007140 Q-loop/lid; other site
1074919007141 ABC transporter signature motif; other site
1074919007142 Walker B; other site
1074919007143 D-loop; other site
1074919007144 H-loop/switch region; other site
1074919007145 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1074919007146 FtsX-like permease family; Region: FtsX; pfam02687
1074919007147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1074919007148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1074919007149 non-specific DNA binding site [nucleotide binding]; other site
1074919007150 salt bridge; other site
1074919007151 sequence-specific DNA binding site [nucleotide binding]; other site
1074919007152 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1074919007153 ParB-like nuclease domain; Region: ParBc; pfam02195
1074919007154 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1074919007155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1074919007156 S-adenosylmethionine binding site [chemical binding]; other site
1074919007157 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1074919007158 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1074919007159 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1074919007160 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1074919007161 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1074919007162 trmE is a tRNA modification GTPase; Region: trmE; cd04164
1074919007163 G1 box; other site
1074919007164 GTP/Mg2+ binding site [chemical binding]; other site
1074919007165 Switch I region; other site
1074919007166 G2 box; other site
1074919007167 Switch II region; other site
1074919007168 G3 box; other site
1074919007169 G4 box; other site
1074919007170 G5 box; other site
1074919007171 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631