-- dump date 20140620_075813 -- class Genbank::misc_feature -- table misc_feature_note -- id note 176280000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 176280000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 176280000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280000004 Walker A motif; other site 176280000005 ATP binding site [chemical binding]; other site 176280000006 Walker B motif; other site 176280000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 176280000008 arginine finger; other site 176280000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 176280000010 DnaA box-binding interface [nucleotide binding]; other site 176280000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 176280000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 176280000013 putative DNA binding surface [nucleotide binding]; other site 176280000014 dimer interface [polypeptide binding]; other site 176280000015 beta-clamp/clamp loader binding surface; other site 176280000016 beta-clamp/translesion DNA polymerase binding surface; other site 176280000017 recombination protein F; Reviewed; Region: recF; PRK00064 176280000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 176280000019 Walker A/P-loop; other site 176280000020 ATP binding site [chemical binding]; other site 176280000021 Q-loop/lid; other site 176280000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280000023 ABC transporter signature motif; other site 176280000024 Walker B; other site 176280000025 D-loop; other site 176280000026 H-loop/switch region; other site 176280000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 176280000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280000029 Mg2+ binding site [ion binding]; other site 176280000030 G-X-G motif; other site 176280000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 176280000032 anchoring element; other site 176280000033 dimer interface [polypeptide binding]; other site 176280000034 ATP binding site [chemical binding]; other site 176280000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 176280000036 active site 176280000037 putative metal-binding site [ion binding]; other site 176280000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 176280000039 DNA gyrase subunit A; Validated; Region: PRK05560 176280000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 176280000041 CAP-like domain; other site 176280000042 active site 176280000043 primary dimer interface [polypeptide binding]; other site 176280000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176280000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176280000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176280000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176280000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176280000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176280000050 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 176280000051 putative substrate binding site [chemical binding]; other site 176280000052 putative ATP binding site [chemical binding]; other site 176280000053 seryl-tRNA synthetase; Provisional; Region: PRK05431 176280000054 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 176280000055 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 176280000056 dimer interface [polypeptide binding]; other site 176280000057 active site 176280000058 motif 1; other site 176280000059 motif 2; other site 176280000060 motif 3; other site 176280000061 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 176280000062 putative catalytic site [active] 176280000063 metal binding site A [ion binding]; metal-binding site 176280000064 phosphate binding site [ion binding]; other site 176280000065 metal binding site C [ion binding]; metal-binding site 176280000066 metal binding site B [ion binding]; metal-binding site 176280000067 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 176280000068 Predicted membrane protein [Function unknown]; Region: COG4392 176280000069 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 176280000070 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 176280000071 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 176280000072 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 176280000073 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 176280000074 DHH family; Region: DHH; pfam01368 176280000075 DHHA1 domain; Region: DHHA1; pfam02272 176280000076 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 176280000077 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 176280000078 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 176280000079 replicative DNA helicase; Region: DnaB; TIGR00665 176280000080 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 176280000081 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 176280000082 Walker A motif; other site 176280000083 ATP binding site [chemical binding]; other site 176280000084 Walker B motif; other site 176280000085 DNA binding loops [nucleotide binding] 176280000086 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 176280000087 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 176280000088 GDP-binding site [chemical binding]; other site 176280000089 ACT binding site; other site 176280000090 IMP binding site; other site 176280000091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176280000092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280000093 active site 176280000094 phosphorylation site [posttranslational modification] 176280000095 intermolecular recognition site; other site 176280000096 dimerization interface [polypeptide binding]; other site 176280000097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176280000098 DNA binding site [nucleotide binding] 176280000099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 176280000100 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 176280000101 dimerization interface [polypeptide binding]; other site 176280000102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 176280000103 putative active site [active] 176280000104 heme pocket [chemical binding]; other site 176280000105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176280000106 dimer interface [polypeptide binding]; other site 176280000107 phosphorylation site [posttranslational modification] 176280000108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280000109 ATP binding site [chemical binding]; other site 176280000110 Mg2+ binding site [ion binding]; other site 176280000111 G-X-G motif; other site 176280000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 176280000113 YycH protein; Region: YycH; pfam07435 176280000114 YycH protein; Region: YycI; cl02015 176280000115 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 176280000116 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 176280000117 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 176280000118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 176280000119 active site 176280000120 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176280000121 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 176280000122 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 176280000123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280000124 Coenzyme A binding pocket [chemical binding]; other site 176280000125 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 176280000126 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 176280000127 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 176280000128 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 176280000129 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 176280000130 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 176280000131 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 176280000132 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 176280000133 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 176280000134 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176280000135 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176280000136 catalytic residues [active] 176280000137 catalytic nucleophile [active] 176280000138 Presynaptic Site I dimer interface [polypeptide binding]; other site 176280000139 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176280000140 Synaptic Flat tetramer interface [polypeptide binding]; other site 176280000141 Synaptic Site I dimer interface [polypeptide binding]; other site 176280000142 DNA binding site [nucleotide binding] 176280000143 Recombinase; Region: Recombinase; pfam07508 176280000144 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 176280000145 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 176280000146 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176280000147 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 176280000148 catalytic residues [active] 176280000149 catalytic nucleophile [active] 176280000150 Recombinase; Region: Recombinase; pfam07508 176280000151 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 176280000152 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 176280000153 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 176280000154 Divergent AAA domain; Region: AAA_4; pfam04326 176280000155 Abortive infection C-terminus; Region: Abi_C; pfam14355 176280000156 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 176280000157 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 176280000158 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 176280000159 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 176280000160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280000161 Coenzyme A binding pocket [chemical binding]; other site 176280000162 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 176280000163 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 176280000164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280000165 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280000166 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 176280000167 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 176280000168 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 176280000169 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176280000170 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 176280000171 catalytic residues [active] 176280000172 catalytic nucleophile [active] 176280000173 Recombinase; Region: Recombinase; pfam07508 176280000174 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 176280000175 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176280000176 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 176280000177 catalytic residues [active] 176280000178 catalytic nucleophile [active] 176280000179 Recombinase; Region: Recombinase; pfam07508 176280000180 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 176280000181 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 176280000182 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 176280000183 Soluble P-type ATPase [General function prediction only]; Region: COG4087 176280000184 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 176280000185 Transposase domain (DUF772); Region: DUF772; pfam05598 176280000186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176280000187 Integrase core domain; Region: rve; pfam00665 176280000188 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 176280000189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176280000190 putative DNA binding site [nucleotide binding]; other site 176280000191 putative Zn2+ binding site [ion binding]; other site 176280000192 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 176280000193 ZIP Zinc transporter; Region: Zip; pfam02535 176280000194 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 176280000195 metal-binding site [ion binding] 176280000196 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 176280000197 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 176280000198 metal-binding site [ion binding] 176280000199 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 176280000200 Soluble P-type ATPase [General function prediction only]; Region: COG4087 176280000201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 176280000202 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 176280000203 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 176280000204 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 176280000205 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 176280000206 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280000207 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280000208 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 176280000209 Cadmium resistance transporter; Region: Cad; pfam03596 176280000210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176280000211 Integrase core domain; Region: rve; pfam00665 176280000212 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 176280000213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280000214 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280000215 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 176280000216 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 176280000217 DNA binding residues [nucleotide binding] 176280000218 dimer interface [polypeptide binding]; other site 176280000219 mercury binding site [ion binding]; other site 176280000220 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 176280000221 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 176280000222 catalytic residues [active] 176280000223 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 176280000224 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 176280000225 metal-binding site [ion binding] 176280000226 mercuric reductase; Region: MerA; TIGR02053 176280000227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280000228 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280000229 alkylmercury lyase; Provisional; Region: PRK13239 176280000230 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 176280000231 Alkylmercury lyase; Region: MerB; pfam03243 176280000232 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 176280000233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176280000234 Integrase core domain; Region: rve; pfam00665 176280000235 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 176280000236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 176280000237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176280000238 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 176280000239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280000240 Walker A/P-loop; other site 176280000241 ATP binding site [chemical binding]; other site 176280000242 Q-loop/lid; other site 176280000243 ABC transporter signature motif; other site 176280000244 Walker B; other site 176280000245 D-loop; other site 176280000246 H-loop/switch region; other site 176280000247 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 176280000248 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 176280000249 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 176280000250 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 176280000251 putative NAD(P) binding site [chemical binding]; other site 176280000252 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 176280000253 orotate phosphoribosyltransferase-like protein; Provisional; Region: PRK02277 176280000254 Integrase core domain; Region: rve; pfam00665 176280000255 Integrase core domain; Region: rve_3; pfam13683 176280000256 carbamate kinase; Reviewed; Region: PRK12686 176280000257 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 176280000258 putative substrate binding site [chemical binding]; other site 176280000259 nucleotide binding site [chemical binding]; other site 176280000260 nucleotide binding site [chemical binding]; other site 176280000261 homodimer interface [polypeptide binding]; other site 176280000262 ornithine carbamoyltransferase; Provisional; Region: PRK04284 176280000263 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 176280000264 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 176280000265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 176280000266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 176280000267 ligand binding site [chemical binding]; other site 176280000268 flexible hinge region; other site 176280000269 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 176280000270 putative switch regulator; other site 176280000271 non-specific DNA interactions [nucleotide binding]; other site 176280000272 DNA binding site [nucleotide binding] 176280000273 sequence specific DNA binding site [nucleotide binding]; other site 176280000274 putative cAMP binding site [chemical binding]; other site 176280000275 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 176280000276 arginine deiminase; Provisional; Region: PRK01388 176280000277 Arginine repressor [Transcription]; Region: ArgR; COG1438 176280000278 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 176280000279 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 176280000280 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 176280000281 Ligand Binding Site [chemical binding]; other site 176280000282 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 176280000283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280000284 catalytic residue [active] 176280000285 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176280000286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280000287 FeS/SAM binding site; other site 176280000288 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 176280000289 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 176280000290 Walker A/P-loop; other site 176280000291 ATP binding site [chemical binding]; other site 176280000292 Q-loop/lid; other site 176280000293 ABC transporter signature motif; other site 176280000294 Walker B; other site 176280000295 D-loop; other site 176280000296 H-loop/switch region; other site 176280000297 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 176280000298 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176280000299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280000300 active site 176280000301 phosphorylation site [posttranslational modification] 176280000302 intermolecular recognition site; other site 176280000303 dimerization interface [polypeptide binding]; other site 176280000304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176280000305 DNA binding site [nucleotide binding] 176280000306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176280000307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176280000308 phosphorylation site [posttranslational modification] 176280000309 dimer interface [polypeptide binding]; other site 176280000310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280000311 ATP binding site [chemical binding]; other site 176280000312 Mg2+ binding site [ion binding]; other site 176280000313 G-X-G motif; other site 176280000314 MFS/sugar transport protein; Region: MFS_2; pfam13347 176280000315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280000316 putative substrate translocation pore; other site 176280000317 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 176280000318 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 176280000319 Soluble P-type ATPase [General function prediction only]; Region: COG4087 176280000320 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 176280000321 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 176280000322 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 176280000323 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 176280000324 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 176280000325 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 176280000326 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176280000327 active site residue [active] 176280000328 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176280000329 active site residue [active] 176280000330 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 176280000331 CPxP motif; other site 176280000332 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 176280000333 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176280000334 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 176280000335 putative homodimer interface [polypeptide binding]; other site 176280000336 putative homotetramer interface [polypeptide binding]; other site 176280000337 putative metal binding site [ion binding]; other site 176280000338 putative homodimer-homodimer interface [polypeptide binding]; other site 176280000339 putative allosteric switch controlling residues; other site 176280000340 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 176280000341 Low molecular weight phosphatase family; Region: LMWPc; cd00115 176280000342 active site 176280000343 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 176280000344 arsenical pump membrane protein; Provisional; Region: PRK15445 176280000345 transmembrane helices; other site 176280000346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176280000347 dimerization interface [polypeptide binding]; other site 176280000348 putative DNA binding site [nucleotide binding]; other site 176280000349 putative Zn2+ binding site [ion binding]; other site 176280000350 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 176280000351 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 176280000352 P loop; other site 176280000353 Nucleotide binding site [chemical binding]; other site 176280000354 DTAP/Switch II; other site 176280000355 Switch I; other site 176280000356 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 176280000357 P loop; other site 176280000358 Nucleotide binding site [chemical binding]; other site 176280000359 DTAP/Switch II; other site 176280000360 Switch I; other site 176280000361 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 176280000362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176280000363 dimerization interface [polypeptide binding]; other site 176280000364 putative DNA binding site [nucleotide binding]; other site 176280000365 putative Zn2+ binding site [ion binding]; other site 176280000366 Predicted permeases [General function prediction only]; Region: COG0701 176280000367 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176280000368 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176280000369 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176280000370 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 176280000371 Mechanosensitive ion channel; Region: MS_channel; pfam00924 176280000372 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 176280000373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 176280000374 active site 176280000375 motif I; other site 176280000376 motif II; other site 176280000377 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 176280000378 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 176280000379 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 176280000380 FMN binding site [chemical binding]; other site 176280000381 active site 176280000382 catalytic residues [active] 176280000383 substrate binding site [chemical binding]; other site 176280000384 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 176280000385 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 176280000386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176280000387 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 176280000388 NAD(P) binding site [chemical binding]; other site 176280000389 active site 176280000390 Integrase core domain; Region: rve; pfam00665 176280000391 Integrase core domain; Region: rve_3; pfam13683 176280000392 Homeodomain-like domain; Region: HTH_23; cl17451 176280000393 Phospholipid methyltransferase; Region: PEMT; cl17370 176280000394 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 176280000395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280000396 putative substrate translocation pore; other site 176280000397 Response regulator receiver domain; Region: Response_reg; pfam00072 176280000398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280000399 active site 176280000400 phosphorylation site [posttranslational modification] 176280000401 intermolecular recognition site; other site 176280000402 dimerization interface [polypeptide binding]; other site 176280000403 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176280000404 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 176280000405 Histidine kinase; Region: His_kinase; pfam06580 176280000406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280000407 ATP binding site [chemical binding]; other site 176280000408 Mg2+ binding site [ion binding]; other site 176280000409 G-X-G motif; other site 176280000410 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 176280000411 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 176280000412 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 176280000413 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176280000414 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 176280000415 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 176280000416 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176280000417 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176280000418 legume lectins; Region: lectin_L-type; cl14058 176280000419 homotetramer interaction site [polypeptide binding]; other site 176280000420 homodimer interaction site [polypeptide binding]; other site 176280000421 carbohydrate binding site [chemical binding]; other site 176280000422 metal binding site [ion binding]; metal-binding site 176280000423 G5 domain; Region: G5; pfam07501 176280000424 G5 domain; Region: G5; pfam07501 176280000425 G5 domain; Region: G5; pfam07501 176280000426 G5 domain; Region: G5; pfam07501 176280000427 G5 domain; Region: G5; pfam07501 176280000428 G5 domain; Region: G5; pfam07501 176280000429 G5 domain; Region: G5; pfam07501 176280000430 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 176280000431 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 176280000432 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 176280000433 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176280000434 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 176280000435 AAA domain; Region: AAA_26; pfam13500 176280000436 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176280000437 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 176280000438 inhibitor-cofactor binding pocket; inhibition site 176280000439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280000440 catalytic residue [active] 176280000441 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 176280000442 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 176280000443 substrate-cofactor binding pocket; other site 176280000444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280000445 catalytic residue [active] 176280000446 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 176280000447 Staphostatin A; Region: Staphostatin_A; pfam09022 176280000448 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 176280000449 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 176280000450 Protein of unknown function, DUF576; Region: DUF576; cl04553 176280000451 Protein of unknown function, DUF576; Region: DUF576; cl04553 176280000452 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 176280000453 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 176280000454 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 176280000455 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 176280000456 Nucleoside recognition; Region: Gate; pfam07670 176280000457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 176280000458 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 176280000459 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 176280000460 intersubunit interface [polypeptide binding]; other site 176280000461 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 176280000462 ApbE family; Region: ApbE; pfam02424 176280000463 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 176280000464 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 176280000465 putative active site [active] 176280000466 putative FMN binding site [chemical binding]; other site 176280000467 putative substrate binding site [chemical binding]; other site 176280000468 putative catalytic residue [active] 176280000469 FMN-binding domain; Region: FMN_bind; cl01081 176280000470 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 176280000471 L-aspartate oxidase; Provisional; Region: PRK06175 176280000472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280000473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280000474 putative substrate translocation pore; other site 176280000475 acetoin reductases; Region: 23BDH; TIGR02415 176280000476 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 176280000477 homotetramer interface [polypeptide binding]; other site 176280000478 NAD binding site [chemical binding]; other site 176280000479 homodimer interface [polypeptide binding]; other site 176280000480 active site 176280000481 substrate binding site [chemical binding]; other site 176280000482 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176280000483 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176280000484 Walker A/P-loop; other site 176280000485 ATP binding site [chemical binding]; other site 176280000486 Q-loop/lid; other site 176280000487 ABC transporter signature motif; other site 176280000488 Walker B; other site 176280000489 D-loop; other site 176280000490 H-loop/switch region; other site 176280000491 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 176280000492 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 176280000493 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 176280000494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 176280000495 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 176280000496 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 176280000497 substrate binding site [chemical binding]; other site 176280000498 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 176280000499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280000500 dimer interface [polypeptide binding]; other site 176280000501 conserved gate region; other site 176280000502 putative PBP binding loops; other site 176280000503 ABC-ATPase subunit interface; other site 176280000504 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 176280000505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280000506 dimer interface [polypeptide binding]; other site 176280000507 conserved gate region; other site 176280000508 putative PBP binding loops; other site 176280000509 ABC-ATPase subunit interface; other site 176280000510 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176280000511 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 176280000512 Walker A/P-loop; other site 176280000513 ATP binding site [chemical binding]; other site 176280000514 Q-loop/lid; other site 176280000515 ABC transporter signature motif; other site 176280000516 Walker B; other site 176280000517 D-loop; other site 176280000518 H-loop/switch region; other site 176280000519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 176280000520 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 176280000521 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176280000522 Walker A/P-loop; other site 176280000523 ATP binding site [chemical binding]; other site 176280000524 Q-loop/lid; other site 176280000525 ABC transporter signature motif; other site 176280000526 Walker B; other site 176280000527 D-loop; other site 176280000528 H-loop/switch region; other site 176280000529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280000530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280000531 putative substrate translocation pore; other site 176280000532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280000533 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 176280000534 Walker A/P-loop; other site 176280000535 ATP binding site [chemical binding]; other site 176280000536 Q-loop/lid; other site 176280000537 ABC transporter signature motif; other site 176280000538 Walker B; other site 176280000539 D-loop; other site 176280000540 H-loop/switch region; other site 176280000541 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 176280000542 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 176280000543 Pyruvate formate lyase 1; Region: PFL1; cd01678 176280000544 coenzyme A binding site [chemical binding]; other site 176280000545 active site 176280000546 catalytic residues [active] 176280000547 glycine loop; other site 176280000548 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 176280000549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280000550 FeS/SAM binding site; other site 176280000551 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 176280000552 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 176280000553 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 176280000554 metal binding site [ion binding]; metal-binding site 176280000555 dimer interface [polypeptide binding]; other site 176280000556 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 176280000557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 176280000558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176280000559 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 176280000560 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 176280000561 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 176280000562 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 176280000563 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 176280000564 active site 176280000565 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 176280000566 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 176280000567 Walker A/P-loop; other site 176280000568 ATP binding site [chemical binding]; other site 176280000569 Q-loop/lid; other site 176280000570 ABC transporter signature motif; other site 176280000571 Walker B; other site 176280000572 D-loop; other site 176280000573 H-loop/switch region; other site 176280000574 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 176280000575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280000576 dimer interface [polypeptide binding]; other site 176280000577 conserved gate region; other site 176280000578 putative PBP binding loops; other site 176280000579 ABC-ATPase subunit interface; other site 176280000580 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 176280000581 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 176280000582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280000583 dimer interface [polypeptide binding]; other site 176280000584 conserved gate region; other site 176280000585 ABC-ATPase subunit interface; other site 176280000586 Predicted esterase [General function prediction only]; Region: COG0627 176280000587 S-formylglutathione hydrolase; Region: PLN02442 176280000588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 176280000589 Predicted membrane protein [Function unknown]; Region: COG1288 176280000590 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 176280000591 carbamate kinase; Reviewed; Region: PRK12686 176280000592 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 176280000593 putative substrate binding site [chemical binding]; other site 176280000594 nucleotide binding site [chemical binding]; other site 176280000595 nucleotide binding site [chemical binding]; other site 176280000596 homodimer interface [polypeptide binding]; other site 176280000597 ornithine carbamoyltransferase; Provisional; Region: PRK04284 176280000598 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 176280000599 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 176280000600 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 176280000601 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 176280000602 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 176280000603 active site 176280000604 metal binding site [ion binding]; metal-binding site 176280000605 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 176280000606 biotin synthase; Validated; Region: PRK06256 176280000607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280000608 FeS/SAM binding site; other site 176280000609 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 176280000610 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 176280000611 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 176280000612 dimer interface [polypeptide binding]; other site 176280000613 active site 176280000614 metal binding site [ion binding]; metal-binding site 176280000615 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 176280000616 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 176280000617 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 176280000618 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 176280000619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280000620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280000621 putative substrate translocation pore; other site 176280000622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280000623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280000624 putative substrate translocation pore; other site 176280000625 Condensation domain; Region: Condensation; pfam00668 176280000626 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 176280000627 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 176280000628 acyl-activating enzyme (AAE) consensus motif; other site 176280000629 AMP binding site [chemical binding]; other site 176280000630 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 176280000631 Condensation domain; Region: Condensation; pfam00668 176280000632 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 176280000633 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 176280000634 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 176280000635 acyl-activating enzyme (AAE) consensus motif; other site 176280000636 AMP binding site [chemical binding]; other site 176280000637 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 176280000638 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 176280000639 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 176280000640 putative NAD(P) binding site [chemical binding]; other site 176280000641 active site 176280000642 putative substrate binding site [chemical binding]; other site 176280000643 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 176280000644 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 176280000645 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 176280000646 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 176280000647 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 176280000648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280000649 putative substrate translocation pore; other site 176280000650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280000651 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 176280000652 MepB protein; Region: MepB; pfam08877 176280000653 Predicted permeases [General function prediction only]; Region: RarD; COG2962 176280000654 NMT1/THI5 like; Region: NMT1; pfam09084 176280000655 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 176280000656 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 176280000657 transmembrane helices; other site 176280000658 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 176280000659 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176280000660 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280000661 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280000662 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 176280000663 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 176280000664 tetramer interface [polypeptide binding]; other site 176280000665 TPP-binding site [chemical binding]; other site 176280000666 heterodimer interface [polypeptide binding]; other site 176280000667 phosphorylation loop region [posttranslational modification] 176280000668 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 176280000669 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 176280000670 alpha subunit interface [polypeptide binding]; other site 176280000671 TPP binding site [chemical binding]; other site 176280000672 heterodimer interface [polypeptide binding]; other site 176280000673 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 176280000674 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 176280000675 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 176280000676 E3 interaction surface; other site 176280000677 lipoyl attachment site [posttranslational modification]; other site 176280000678 e3 binding domain; Region: E3_binding; pfam02817 176280000679 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 176280000680 iron-sulfur cluster-binding protein; Region: TIGR00273 176280000681 BCCT family transporter; Region: BCCT; pfam02028 176280000682 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 176280000683 putative substrate binding pocket [chemical binding]; other site 176280000684 AC domain interface; other site 176280000685 catalytic triad [active] 176280000686 AB domain interface; other site 176280000687 interchain disulfide; other site 176280000688 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 176280000689 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 176280000690 active site residue [active] 176280000691 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 176280000692 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 176280000693 Strictosidine synthase; Region: Str_synth; pfam03088 176280000694 Uncharacterized conserved protein [Function unknown]; Region: COG2353 176280000695 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 176280000696 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 176280000697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 176280000698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 176280000699 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 176280000700 Uncharacterized conserved protein [Function unknown]; Region: COG2128 176280000701 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 176280000702 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 176280000703 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 176280000704 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 176280000705 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 176280000706 histidinol dehydrogenase; Region: hisD; TIGR00069 176280000707 NAD binding site [chemical binding]; other site 176280000708 dimerization interface [polypeptide binding]; other site 176280000709 product binding site; other site 176280000710 substrate binding site [chemical binding]; other site 176280000711 zinc binding site [ion binding]; other site 176280000712 catalytic residues [active] 176280000713 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 176280000714 putative active site pocket [active] 176280000715 4-fold oligomerization interface [polypeptide binding]; other site 176280000716 metal binding residues [ion binding]; metal-binding site 176280000717 3-fold/trimer interface [polypeptide binding]; other site 176280000718 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 176280000719 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 176280000720 putative active site [active] 176280000721 oxyanion strand; other site 176280000722 catalytic triad [active] 176280000723 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 176280000724 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 176280000725 catalytic residues [active] 176280000726 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 176280000727 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 176280000728 substrate binding site [chemical binding]; other site 176280000729 glutamase interaction surface [polypeptide binding]; other site 176280000730 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 176280000731 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 176280000732 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 176280000733 metal binding site [ion binding]; metal-binding site 176280000734 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 176280000735 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 176280000736 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 176280000737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280000738 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280000739 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 176280000740 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 176280000741 Nucleoside recognition; Region: Gate; pfam07670 176280000742 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 176280000743 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 176280000744 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 176280000745 UvrB/uvrC motif; Region: UVR; pfam02151 176280000746 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 176280000747 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 176280000748 ADP binding site [chemical binding]; other site 176280000749 phosphagen binding site; other site 176280000750 substrate specificity loop; other site 176280000751 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 176280000752 Clp amino terminal domain; Region: Clp_N; pfam02861 176280000753 Clp amino terminal domain; Region: Clp_N; pfam02861 176280000754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280000755 Walker A motif; other site 176280000756 ATP binding site [chemical binding]; other site 176280000757 Walker B motif; other site 176280000758 arginine finger; other site 176280000759 UvrB/uvrC motif; Region: UVR; pfam02151 176280000760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280000761 Walker A motif; other site 176280000762 ATP binding site [chemical binding]; other site 176280000763 Walker B motif; other site 176280000764 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 176280000765 DNA repair protein RadA; Provisional; Region: PRK11823 176280000766 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 176280000767 Walker A motif/ATP binding site; other site 176280000768 ATP binding site [chemical binding]; other site 176280000769 Walker B motif; other site 176280000770 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 176280000771 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 176280000772 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 176280000773 putative active site [active] 176280000774 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 176280000775 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 176280000776 active site 176280000777 HIGH motif; other site 176280000778 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 176280000779 active site 176280000780 KMSKS motif; other site 176280000781 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 176280000782 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 176280000783 trimer interface [polypeptide binding]; other site 176280000784 active site 176280000785 substrate binding site [chemical binding]; other site 176280000786 CoA binding site [chemical binding]; other site 176280000787 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 176280000788 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 176280000789 active site 176280000790 HIGH motif; other site 176280000791 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 176280000792 KMSKS motif; other site 176280000793 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 176280000794 tRNA binding surface [nucleotide binding]; other site 176280000795 anticodon binding site; other site 176280000796 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 176280000797 active site 176280000798 metal binding site [ion binding]; metal-binding site 176280000799 dimerization interface [polypeptide binding]; other site 176280000800 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 176280000801 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 176280000802 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 176280000803 YacP-like NYN domain; Region: NYN_YacP; cl01491 176280000804 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 176280000805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 176280000806 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 176280000807 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 176280000808 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 176280000809 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 176280000810 putative homodimer interface [polypeptide binding]; other site 176280000811 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 176280000812 heterodimer interface [polypeptide binding]; other site 176280000813 homodimer interface [polypeptide binding]; other site 176280000814 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 176280000815 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 176280000816 23S rRNA interface [nucleotide binding]; other site 176280000817 L7/L12 interface [polypeptide binding]; other site 176280000818 putative thiostrepton binding site; other site 176280000819 L25 interface [polypeptide binding]; other site 176280000820 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 176280000821 mRNA/rRNA interface [nucleotide binding]; other site 176280000822 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 176280000823 23S rRNA interface [nucleotide binding]; other site 176280000824 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 176280000825 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 176280000826 peripheral dimer interface [polypeptide binding]; other site 176280000827 core dimer interface [polypeptide binding]; other site 176280000828 L10 interface [polypeptide binding]; other site 176280000829 L11 interface [polypeptide binding]; other site 176280000830 putative EF-Tu interaction site [polypeptide binding]; other site 176280000831 putative EF-G interaction site [polypeptide binding]; other site 176280000832 Methyltransferase domain; Region: Methyltransf_31; pfam13847 176280000833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280000834 S-adenosylmethionine binding site [chemical binding]; other site 176280000835 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 176280000836 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 176280000837 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 176280000838 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 176280000839 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 176280000840 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 176280000841 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 176280000842 RPB10 interaction site [polypeptide binding]; other site 176280000843 RPB1 interaction site [polypeptide binding]; other site 176280000844 RPB11 interaction site [polypeptide binding]; other site 176280000845 RPB3 interaction site [polypeptide binding]; other site 176280000846 RPB12 interaction site [polypeptide binding]; other site 176280000847 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 176280000848 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 176280000849 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 176280000850 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 176280000851 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 176280000852 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 176280000853 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 176280000854 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 176280000855 G-loop; other site 176280000856 DNA binding site [nucleotide binding] 176280000857 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 176280000858 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 176280000859 S17 interaction site [polypeptide binding]; other site 176280000860 S8 interaction site; other site 176280000861 16S rRNA interaction site [nucleotide binding]; other site 176280000862 streptomycin interaction site [chemical binding]; other site 176280000863 23S rRNA interaction site [nucleotide binding]; other site 176280000864 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 176280000865 30S ribosomal protein S7; Validated; Region: PRK05302 176280000866 elongation factor G; Reviewed; Region: PRK00007 176280000867 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 176280000868 G1 box; other site 176280000869 putative GEF interaction site [polypeptide binding]; other site 176280000870 GTP/Mg2+ binding site [chemical binding]; other site 176280000871 Switch I region; other site 176280000872 G2 box; other site 176280000873 G3 box; other site 176280000874 Switch II region; other site 176280000875 G4 box; other site 176280000876 G5 box; other site 176280000877 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 176280000878 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 176280000879 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 176280000880 elongation factor Tu; Reviewed; Region: PRK00049 176280000881 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 176280000882 G1 box; other site 176280000883 GEF interaction site [polypeptide binding]; other site 176280000884 GTP/Mg2+ binding site [chemical binding]; other site 176280000885 Switch I region; other site 176280000886 G2 box; other site 176280000887 G3 box; other site 176280000888 Switch II region; other site 176280000889 G4 box; other site 176280000890 G5 box; other site 176280000891 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 176280000892 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 176280000893 Antibiotic Binding Site [chemical binding]; other site 176280000894 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176280000895 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 176280000896 metal binding site [ion binding]; metal-binding site 176280000897 dimer interface [polypeptide binding]; other site 176280000898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280000899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 176280000900 Coenzyme A binding pocket [chemical binding]; other site 176280000901 ornithine cyclodeaminase; Validated; Region: PRK08618 176280000902 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 176280000903 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 176280000904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176280000905 NAD(P) binding site [chemical binding]; other site 176280000906 active site 176280000907 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 176280000908 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 176280000909 homodimer interface [polypeptide binding]; other site 176280000910 substrate-cofactor binding pocket; other site 176280000911 catalytic residue [active] 176280000912 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 176280000913 substrate binding site; other site 176280000914 dimer interface; other site 176280000915 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 176280000916 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 176280000917 NAD(P) binding site [chemical binding]; other site 176280000918 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176280000919 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 176280000920 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 176280000921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280000922 motif II; other site 176280000923 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 176280000924 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 176280000925 active site 176280000926 non-prolyl cis peptide bond; other site 176280000927 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 176280000928 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 176280000929 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 176280000930 putative NAD(P) binding site [chemical binding]; other site 176280000931 active site 176280000932 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 176280000933 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 176280000934 Substrate-binding site [chemical binding]; other site 176280000935 Substrate specificity [chemical binding]; other site 176280000936 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 176280000937 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 176280000938 Substrate-binding site [chemical binding]; other site 176280000939 Substrate specificity [chemical binding]; other site 176280000940 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 176280000941 nucleoside/Zn binding site; other site 176280000942 dimer interface [polypeptide binding]; other site 176280000943 catalytic motif [active] 176280000944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280000945 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 176280000946 active site 176280000947 motif I; other site 176280000948 motif II; other site 176280000949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280000950 Predicted flavoprotein [General function prediction only]; Region: COG0431 176280000951 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 176280000952 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176280000953 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 176280000954 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 176280000955 Cna protein B-type domain; Region: Cna_B; pfam05738 176280000956 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 176280000957 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 176280000958 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176280000959 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 176280000960 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 176280000961 putative GTP cyclohydrolase; Provisional; Region: PRK13674 176280000962 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 176280000963 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 176280000964 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 176280000965 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 176280000966 active site 176280000967 trimer interface [polypeptide binding]; other site 176280000968 allosteric site; other site 176280000969 active site lid [active] 176280000970 hexamer (dimer of trimers) interface [polypeptide binding]; other site 176280000971 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 176280000972 active site 176280000973 dimer interface [polypeptide binding]; other site 176280000974 magnesium binding site [ion binding]; other site 176280000975 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 176280000976 tetramer interface [polypeptide binding]; other site 176280000977 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 176280000978 active site 176280000979 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 176280000980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280000981 motif II; other site 176280000982 AMP-binding enzyme; Region: AMP-binding; pfam00501 176280000983 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 176280000984 acyl-activating enzyme (AAE) consensus motif; other site 176280000985 active site 176280000986 AMP binding site [chemical binding]; other site 176280000987 CoA binding site [chemical binding]; other site 176280000988 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 176280000989 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 176280000990 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 176280000991 dimer interface [polypeptide binding]; other site 176280000992 active site 176280000993 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 176280000994 dimer interface [polypeptide binding]; other site 176280000995 substrate binding site [chemical binding]; other site 176280000996 ATP binding site [chemical binding]; other site 176280000997 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 176280000998 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 176280000999 active site 176280001000 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 176280001001 ligand binding site [chemical binding]; other site 176280001002 active site 176280001003 UGI interface [polypeptide binding]; other site 176280001004 catalytic site [active] 176280001005 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 176280001006 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 176280001007 Uncharacterized conserved protein [Function unknown]; Region: COG3610 176280001008 Uncharacterized conserved protein [Function unknown]; Region: COG2966 176280001009 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 176280001010 putative heme peroxidase; Provisional; Region: PRK12276 176280001011 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 176280001012 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 176280001013 mevalonate kinase; Region: mevalon_kin; TIGR00549 176280001014 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 176280001015 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 176280001016 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 176280001017 diphosphomevalonate decarboxylase; Region: PLN02407 176280001018 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 176280001019 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 176280001020 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 176280001021 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 176280001022 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280001023 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280001024 Predicted transcriptional regulator [Transcription]; Region: COG1959 176280001025 Transcriptional regulator; Region: Rrf2; pfam02082 176280001026 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 176280001027 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 176280001028 active site 176280001029 catalytic tetrad [active] 176280001030 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 176280001031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280001032 Coenzyme A binding pocket [chemical binding]; other site 176280001033 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 176280001034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176280001035 Zn2+ binding site [ion binding]; other site 176280001036 Mg2+ binding site [ion binding]; other site 176280001037 YwhD family; Region: YwhD; pfam08741 176280001038 hypothetical protein; Provisional; Region: PRK04194 176280001039 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 176280001040 AIR carboxylase; Region: AIRC; smart01001 176280001041 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 176280001042 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 176280001043 Ligand Binding Site [chemical binding]; other site 176280001044 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 176280001045 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 176280001046 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 176280001047 NAD binding site [chemical binding]; other site 176280001048 substrate binding site [chemical binding]; other site 176280001049 catalytic Zn binding site [ion binding]; other site 176280001050 tetramer interface [polypeptide binding]; other site 176280001051 structural Zn binding site [ion binding]; other site 176280001052 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 176280001053 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 176280001054 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 176280001055 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 176280001056 active site 176280001057 HIGH motif; other site 176280001058 KMSK motif region; other site 176280001059 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 176280001060 tRNA binding surface [nucleotide binding]; other site 176280001061 anticodon binding site; other site 176280001062 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 176280001063 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 176280001064 minor groove reading motif; other site 176280001065 helix-hairpin-helix signature motif; other site 176280001066 substrate binding pocket [chemical binding]; other site 176280001067 active site 176280001068 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 176280001069 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 176280001070 DNA binding residues [nucleotide binding] 176280001071 dimer interface [polypeptide binding]; other site 176280001072 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 176280001073 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 176280001074 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 176280001075 putative binding site residues; other site 176280001076 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 176280001077 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176280001078 putative PBP binding regions; other site 176280001079 ABC-ATPase subunit interface; other site 176280001080 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 176280001081 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 176280001082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280001083 motif II; other site 176280001084 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 176280001085 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 176280001086 PGAP1-like protein; Region: PGAP1; pfam07819 176280001087 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 176280001088 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176280001089 Transcriptional regulators [Transcription]; Region: MarR; COG1846 176280001090 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 176280001091 HlyD family secretion protein; Region: HlyD_3; pfam13437 176280001092 Protein of unknown function, DUF606; Region: DUF606; pfam04657 176280001093 Protein of unknown function, DUF606; Region: DUF606; pfam04657 176280001094 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 176280001095 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 176280001096 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 176280001097 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176280001098 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 176280001099 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 176280001100 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 176280001101 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 176280001102 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176280001103 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 176280001104 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 176280001105 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 176280001106 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 176280001107 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 176280001108 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 176280001109 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 176280001110 metal binding site [ion binding]; metal-binding site 176280001111 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 176280001112 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176280001113 ABC-ATPase subunit interface; other site 176280001114 dimer interface [polypeptide binding]; other site 176280001115 putative PBP binding regions; other site 176280001116 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 176280001117 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 176280001118 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 176280001119 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 176280001120 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 176280001121 FeoA domain; Region: FeoA; pfam04023 176280001122 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 176280001123 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 176280001124 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 176280001125 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 176280001126 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 176280001127 Walker A/P-loop; other site 176280001128 ATP binding site [chemical binding]; other site 176280001129 Q-loop/lid; other site 176280001130 ABC transporter signature motif; other site 176280001131 Walker B; other site 176280001132 D-loop; other site 176280001133 H-loop/switch region; other site 176280001134 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 176280001135 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176280001136 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 176280001137 active site 176280001138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 176280001139 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 176280001140 active site 176280001141 nucleotide binding site [chemical binding]; other site 176280001142 HIGH motif; other site 176280001143 KMSKS motif; other site 176280001144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 176280001145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 176280001146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280001147 Walker A/P-loop; other site 176280001148 ATP binding site [chemical binding]; other site 176280001149 Q-loop/lid; other site 176280001150 ABC transporter signature motif; other site 176280001151 Walker B; other site 176280001152 D-loop; other site 176280001153 H-loop/switch region; other site 176280001154 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 176280001155 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 176280001156 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 176280001157 Uncharacterized conserved protein [Function unknown]; Region: COG1284 176280001158 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 176280001159 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 176280001160 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 176280001161 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 176280001162 Walker A/P-loop; other site 176280001163 ATP binding site [chemical binding]; other site 176280001164 Q-loop/lid; other site 176280001165 ABC transporter signature motif; other site 176280001166 Walker B; other site 176280001167 D-loop; other site 176280001168 H-loop/switch region; other site 176280001169 Uncharacterized membrane protein [Function unknown]; Region: COG3949 176280001170 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 176280001171 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 176280001172 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 176280001173 substrate binding pocket [chemical binding]; other site 176280001174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 176280001175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280001176 Coenzyme A binding pocket [chemical binding]; other site 176280001177 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 176280001178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176280001179 NAD(P) binding site [chemical binding]; other site 176280001180 active site 176280001181 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176280001182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280001183 active site 176280001184 phosphorylation site [posttranslational modification] 176280001185 intermolecular recognition site; other site 176280001186 dimerization interface [polypeptide binding]; other site 176280001187 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176280001188 DNA binding site [nucleotide binding] 176280001189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176280001190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 176280001191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280001192 ATP binding site [chemical binding]; other site 176280001193 Mg2+ binding site [ion binding]; other site 176280001194 G-X-G motif; other site 176280001195 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176280001196 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176280001197 Walker A/P-loop; other site 176280001198 ATP binding site [chemical binding]; other site 176280001199 Q-loop/lid; other site 176280001200 ABC transporter signature motif; other site 176280001201 Walker B; other site 176280001202 D-loop; other site 176280001203 H-loop/switch region; other site 176280001204 FtsX-like permease family; Region: FtsX; pfam02687 176280001205 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 176280001206 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 176280001207 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176280001208 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 176280001209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176280001210 Surface antigen [General function prediction only]; Region: COG3942 176280001211 CHAP domain; Region: CHAP; pfam05257 176280001212 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 176280001213 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176280001214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 176280001215 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176280001216 hypothetical protein; Provisional; Region: PRK12378 176280001217 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 176280001218 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 176280001219 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 176280001220 Hemerythrin-like domain; Region: Hr-like; cd12108 176280001221 Fe binding site [ion binding]; other site 176280001222 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 176280001223 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 176280001224 heme-binding site [chemical binding]; other site 176280001225 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 176280001226 FAD binding pocket [chemical binding]; other site 176280001227 FAD binding motif [chemical binding]; other site 176280001228 phosphate binding motif [ion binding]; other site 176280001229 beta-alpha-beta structure motif; other site 176280001230 NAD binding pocket [chemical binding]; other site 176280001231 Heme binding pocket [chemical binding]; other site 176280001232 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 176280001233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176280001234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 176280001235 dimerization interface [polypeptide binding]; other site 176280001236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280001237 sugar efflux transporter; Region: 2A0120; TIGR00899 176280001238 putative substrate translocation pore; other site 176280001239 Protein of unknown function (DUF456); Region: DUF456; pfam04306 176280001240 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 176280001241 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 176280001242 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 176280001243 hypothetical protein; Validated; Region: PRK00124 176280001244 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 176280001245 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 176280001246 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 176280001247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 176280001248 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 176280001249 Walker A/P-loop; other site 176280001250 ATP binding site [chemical binding]; other site 176280001251 Q-loop/lid; other site 176280001252 ABC transporter signature motif; other site 176280001253 Walker B; other site 176280001254 D-loop; other site 176280001255 H-loop/switch region; other site 176280001256 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 176280001257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 176280001258 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 176280001259 Walker A/P-loop; other site 176280001260 ATP binding site [chemical binding]; other site 176280001261 Q-loop/lid; other site 176280001262 ABC transporter signature motif; other site 176280001263 Walker B; other site 176280001264 D-loop; other site 176280001265 H-loop/switch region; other site 176280001266 Transcriptional regulators [Transcription]; Region: MarR; COG1846 176280001267 MarR family; Region: MarR; pfam01047 176280001268 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 176280001269 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 176280001270 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 176280001271 malate dehydrogenase; Reviewed; Region: PRK06223 176280001272 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 176280001273 NAD(P) binding site [chemical binding]; other site 176280001274 dimer interface [polypeptide binding]; other site 176280001275 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176280001276 substrate binding site [chemical binding]; other site 176280001277 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 176280001278 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 176280001279 transmembrane helices; other site 176280001280 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 176280001281 DNA photolyase; Region: DNA_photolyase; pfam00875 176280001282 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 176280001283 D-galactonate transporter; Region: 2A0114; TIGR00893 176280001284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280001285 putative substrate translocation pore; other site 176280001286 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 176280001287 putative deacylase active site [active] 176280001288 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 176280001289 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 176280001290 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 176280001291 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 176280001292 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 176280001293 putative substrate binding site [chemical binding]; other site 176280001294 putative ATP binding site [chemical binding]; other site 176280001295 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 176280001296 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 176280001297 active site 176280001298 phosphorylation site [posttranslational modification] 176280001299 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 176280001300 active site 176280001301 P-loop; other site 176280001302 phosphorylation site [posttranslational modification] 176280001303 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 176280001304 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 176280001305 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 176280001306 active site 176280001307 dimer interface [polypeptide binding]; other site 176280001308 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 176280001309 Domain of unknown function DUF21; Region: DUF21; pfam01595 176280001310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 176280001311 Transporter associated domain; Region: CorC_HlyC; smart01091 176280001312 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 176280001313 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 176280001314 active site 176280001315 catalytic tetrad [active] 176280001316 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 176280001317 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 176280001318 Ligand binding site; other site 176280001319 Putative Catalytic site; other site 176280001320 DXD motif; other site 176280001321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176280001322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176280001323 dimer interface [polypeptide binding]; other site 176280001324 phosphorylation site [posttranslational modification] 176280001325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280001326 ATP binding site [chemical binding]; other site 176280001327 Mg2+ binding site [ion binding]; other site 176280001328 G-X-G motif; other site 176280001329 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176280001330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280001331 active site 176280001332 phosphorylation site [posttranslational modification] 176280001333 intermolecular recognition site; other site 176280001334 dimerization interface [polypeptide binding]; other site 176280001335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176280001336 DNA binding site [nucleotide binding] 176280001337 Electron transfer DM13; Region: DM13; pfam10517 176280001338 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 176280001339 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 176280001340 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 176280001341 active site 176280001342 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 176280001343 Ligand Binding Site [chemical binding]; other site 176280001344 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 176280001345 Glutamine amidotransferase class-I; Region: GATase; pfam00117 176280001346 glutamine binding [chemical binding]; other site 176280001347 catalytic triad [active] 176280001348 chorismate binding enzyme; Region: Chorismate_bind; cl10555 176280001349 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 176280001350 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 176280001351 substrate-cofactor binding pocket; other site 176280001352 Aminotransferase class IV; Region: Aminotran_4; pfam01063 176280001353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280001354 catalytic residue [active] 176280001355 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 176280001356 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 176280001357 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 176280001358 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 176280001359 Sulfatase; Region: Sulfatase; pfam00884 176280001360 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280001361 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 176280001362 ZIP Zinc transporter; Region: Zip; pfam02535 176280001363 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 176280001364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280001365 Walker A/P-loop; other site 176280001366 ATP binding site [chemical binding]; other site 176280001367 Q-loop/lid; other site 176280001368 ABC transporter signature motif; other site 176280001369 Walker B; other site 176280001370 D-loop; other site 176280001371 H-loop/switch region; other site 176280001372 ABC transporter; Region: ABC_tran_2; pfam12848 176280001373 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176280001374 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 176280001375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176280001376 ATP binding site [chemical binding]; other site 176280001377 putative Mg++ binding site [ion binding]; other site 176280001378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280001379 nucleotide binding region [chemical binding]; other site 176280001380 ATP-binding site [chemical binding]; other site 176280001381 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 176280001382 HRDC domain; Region: HRDC; pfam00570 176280001383 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 176280001384 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 176280001385 Walker A/P-loop; other site 176280001386 ATP binding site [chemical binding]; other site 176280001387 Q-loop/lid; other site 176280001388 ABC transporter signature motif; other site 176280001389 Walker B; other site 176280001390 D-loop; other site 176280001391 H-loop/switch region; other site 176280001392 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 176280001393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280001394 dimer interface [polypeptide binding]; other site 176280001395 conserved gate region; other site 176280001396 ABC-ATPase subunit interface; other site 176280001397 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 176280001398 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 176280001399 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 176280001400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 176280001401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280001402 homodimer interface [polypeptide binding]; other site 176280001403 catalytic residue [active] 176280001404 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 176280001405 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 176280001406 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 176280001407 putative catalytic cysteine [active] 176280001408 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 176280001409 putative active site [active] 176280001410 metal binding site [ion binding]; metal-binding site 176280001411 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 176280001412 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 176280001413 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 176280001414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280001415 putative substrate translocation pore; other site 176280001416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280001417 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 176280001418 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 176280001419 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 176280001420 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 176280001421 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 176280001422 Class I ribonucleotide reductase; Region: RNR_I; cd01679 176280001423 active site 176280001424 dimer interface [polypeptide binding]; other site 176280001425 catalytic residues [active] 176280001426 effector binding site; other site 176280001427 R2 peptide binding site; other site 176280001428 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 176280001429 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 176280001430 dimer interface [polypeptide binding]; other site 176280001431 putative radical transfer pathway; other site 176280001432 diiron center [ion binding]; other site 176280001433 tyrosyl radical; other site 176280001434 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176280001435 ABC-ATPase subunit interface; other site 176280001436 dimer interface [polypeptide binding]; other site 176280001437 putative PBP binding regions; other site 176280001438 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176280001439 ABC-ATPase subunit interface; other site 176280001440 dimer interface [polypeptide binding]; other site 176280001441 putative PBP binding regions; other site 176280001442 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 176280001443 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 176280001444 Walker A/P-loop; other site 176280001445 ATP binding site [chemical binding]; other site 176280001446 Q-loop/lid; other site 176280001447 ABC transporter signature motif; other site 176280001448 Walker B; other site 176280001449 D-loop; other site 176280001450 H-loop/switch region; other site 176280001451 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 176280001452 putative ligand binding residues [chemical binding]; other site 176280001453 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 176280001454 CHY zinc finger; Region: zf-CHY; pfam05495 176280001455 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 176280001456 FAD binding domain; Region: FAD_binding_4; pfam01565 176280001457 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 176280001458 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 176280001459 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 176280001460 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 176280001461 peptidase T; Region: peptidase-T; TIGR01882 176280001462 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 176280001463 metal binding site [ion binding]; metal-binding site 176280001464 dimer interface [polypeptide binding]; other site 176280001465 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 176280001466 Uncharacterized conserved protein [Function unknown]; Region: COG2966 176280001467 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 176280001468 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 176280001469 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 176280001470 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 176280001471 metal binding site [ion binding]; metal-binding site 176280001472 active site 176280001473 I-site; other site 176280001474 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 176280001475 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 176280001476 Mg++ binding site [ion binding]; other site 176280001477 putative catalytic motif [active] 176280001478 substrate binding site [chemical binding]; other site 176280001479 Uncharacterized conserved protein [Function unknown]; Region: COG1739 176280001480 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 176280001481 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 176280001482 EDD domain protein, DegV family; Region: DegV; TIGR00762 176280001483 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 176280001484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176280001485 putative Mg++ binding site [ion binding]; other site 176280001486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280001487 nucleotide binding region [chemical binding]; other site 176280001488 ATP-binding site [chemical binding]; other site 176280001489 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 176280001490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176280001491 active site 176280001492 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 176280001493 30S subunit binding site; other site 176280001494 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 176280001495 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 176280001496 SEC-C motif; Region: SEC-C; pfam02810 176280001497 peptide chain release factor 2; Provisional; Region: PRK06746 176280001498 This domain is found in peptide chain release factors; Region: PCRF; smart00937 176280001499 RF-1 domain; Region: RF-1; pfam00472 176280001500 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 176280001501 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176280001502 CHAP domain; Region: CHAP; pfam05257 176280001503 Surface antigen [General function prediction only]; Region: COG3942 176280001504 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176280001505 Zn2+ binding site [ion binding]; other site 176280001506 Mg2+ binding site [ion binding]; other site 176280001507 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 176280001508 excinuclease ABC subunit B; Provisional; Region: PRK05298 176280001509 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176280001510 ATP binding site [chemical binding]; other site 176280001511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280001512 nucleotide binding region [chemical binding]; other site 176280001513 ATP-binding site [chemical binding]; other site 176280001514 Ultra-violet resistance protein B; Region: UvrB; pfam12344 176280001515 UvrB/uvrC motif; Region: UVR; pfam02151 176280001516 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 176280001517 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 176280001518 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 176280001519 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 176280001520 HPr kinase/phosphorylase; Provisional; Region: PRK05428 176280001521 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 176280001522 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 176280001523 Hpr binding site; other site 176280001524 active site 176280001525 homohexamer subunit interaction site [polypeptide binding]; other site 176280001526 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 176280001527 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 176280001528 trimer interface [polypeptide binding]; other site 176280001529 active site 176280001530 substrate binding site [chemical binding]; other site 176280001531 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 176280001532 CoA binding site [chemical binding]; other site 176280001533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176280001534 binding surface 176280001535 TPR motif; other site 176280001536 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 176280001537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176280001538 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280001539 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 176280001540 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 176280001541 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 176280001542 phosphate binding site [ion binding]; other site 176280001543 dimer interface [polypeptide binding]; other site 176280001544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 176280001545 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 176280001546 Clp protease; Region: CLP_protease; pfam00574 176280001547 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 176280001548 oligomer interface [polypeptide binding]; other site 176280001549 active site residues [active] 176280001550 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 176280001551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176280001552 NAD(P) binding site [chemical binding]; other site 176280001553 active site 176280001554 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 176280001555 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 176280001556 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 176280001557 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 176280001558 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 176280001559 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 176280001560 Phosphoglycerate kinase; Region: PGK; pfam00162 176280001561 substrate binding site [chemical binding]; other site 176280001562 hinge regions; other site 176280001563 ADP binding site [chemical binding]; other site 176280001564 catalytic site [active] 176280001565 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 176280001566 triosephosphate isomerase; Provisional; Region: PRK14565 176280001567 substrate binding site [chemical binding]; other site 176280001568 dimer interface [polypeptide binding]; other site 176280001569 catalytic triad [active] 176280001570 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 176280001571 phosphoglyceromutase; Provisional; Region: PRK05434 176280001572 enolase; Provisional; Region: eno; PRK00077 176280001573 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 176280001574 dimer interface [polypeptide binding]; other site 176280001575 metal binding site [ion binding]; metal-binding site 176280001576 substrate binding pocket [chemical binding]; other site 176280001577 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 176280001578 Esterase/lipase [General function prediction only]; Region: COG1647 176280001579 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 176280001580 ribonuclease R; Region: RNase_R; TIGR02063 176280001581 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 176280001582 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 176280001583 RNB domain; Region: RNB; pfam00773 176280001584 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 176280001585 RNA binding site [nucleotide binding]; other site 176280001586 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 176280001587 SmpB-tmRNA interface; other site 176280001588 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 176280001589 DNA binding site [nucleotide binding] 176280001590 Int/Topo IB signature motif; other site 176280001591 active site 176280001592 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 176280001593 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 176280001594 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 176280001595 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 176280001596 active site 176280001597 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 176280001598 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 176280001599 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 176280001600 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 176280001601 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 176280001602 DNA-binding site [nucleotide binding]; DNA binding site 176280001603 RNA-binding motif; other site 176280001604 Protein of unknown function (DUF867); Region: DUF867; pfam05908 176280001605 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 176280001606 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 176280001607 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 176280001608 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 176280001609 catalytic core [active] 176280001610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 176280001611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 176280001612 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 176280001613 Coenzyme A binding pocket [chemical binding]; other site 176280001614 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 176280001615 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 176280001616 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 176280001617 active site 176280001618 catalytic residue [active] 176280001619 dimer interface [polypeptide binding]; other site 176280001620 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 176280001621 putative FMN binding site [chemical binding]; other site 176280001622 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176280001623 catalytic residues [active] 176280001624 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 176280001625 ArsC family; Region: ArsC; pfam03960 176280001626 putative ArsC-like catalytic residues; other site 176280001627 putative TRX-like catalytic residues [active] 176280001628 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 176280001629 lipoyl attachment site [posttranslational modification]; other site 176280001630 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 176280001631 putative active site [active] 176280001632 putative metal binding site [ion binding]; other site 176280001633 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176280001634 catalytic residues [active] 176280001635 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 176280001636 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 176280001637 Walker A/P-loop; other site 176280001638 ATP binding site [chemical binding]; other site 176280001639 Q-loop/lid; other site 176280001640 ABC transporter signature motif; other site 176280001641 Walker B; other site 176280001642 D-loop; other site 176280001643 H-loop/switch region; other site 176280001644 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 176280001645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280001646 dimer interface [polypeptide binding]; other site 176280001647 conserved gate region; other site 176280001648 ABC-ATPase subunit interface; other site 176280001649 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 176280001650 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 176280001651 Predicted membrane protein [Function unknown]; Region: COG2035 176280001652 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 176280001653 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 176280001654 Walker A/P-loop; other site 176280001655 ATP binding site [chemical binding]; other site 176280001656 Q-loop/lid; other site 176280001657 ABC transporter signature motif; other site 176280001658 Walker B; other site 176280001659 D-loop; other site 176280001660 H-loop/switch region; other site 176280001661 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 176280001662 FeS assembly protein SufD; Region: sufD; TIGR01981 176280001663 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 176280001664 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 176280001665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176280001666 catalytic residue [active] 176280001667 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 176280001668 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 176280001669 trimerization site [polypeptide binding]; other site 176280001670 active site 176280001671 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 176280001672 FeS assembly protein SufB; Region: sufB; TIGR01980 176280001673 Domain of unknown function DUF21; Region: DUF21; pfam01595 176280001674 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 176280001675 Protein of unknown function DUF72; Region: DUF72; pfam01904 176280001676 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 176280001677 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 176280001678 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 176280001679 active site 176280001680 metal binding site [ion binding]; metal-binding site 176280001681 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 176280001682 lipoyl synthase; Provisional; Region: PRK05481 176280001683 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280001684 FeS/SAM binding site; other site 176280001685 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 176280001686 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 176280001687 Uncharacterized conserved protein [Function unknown]; Region: COG2445 176280001688 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 176280001689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280001690 active site 176280001691 motif I; other site 176280001692 motif II; other site 176280001693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280001694 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 176280001695 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 176280001696 dimerization interface [polypeptide binding]; other site 176280001697 ligand binding site [chemical binding]; other site 176280001698 NADP binding site [chemical binding]; other site 176280001699 catalytic site [active] 176280001700 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 176280001701 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 176280001702 acyl-activating enzyme (AAE) consensus motif; other site 176280001703 AMP binding site [chemical binding]; other site 176280001704 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 176280001705 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 176280001706 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 176280001707 DltD N-terminal region; Region: DltD_N; pfam04915 176280001708 DltD central region; Region: DltD_M; pfam04918 176280001709 DltD C-terminal region; Region: DltD_C; pfam04914 176280001710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280001711 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280001712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 176280001713 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 176280001714 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 176280001715 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 176280001716 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 176280001717 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 176280001718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280001719 hypothetical protein; Provisional; Region: PRK13669 176280001720 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 176280001721 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 176280001722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280001723 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 176280001724 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 176280001725 interface (dimer of trimers) [polypeptide binding]; other site 176280001726 Substrate-binding/catalytic site; other site 176280001727 Zn-binding sites [ion binding]; other site 176280001728 Predicted permease [General function prediction only]; Region: COG2056 176280001729 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 176280001730 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 176280001731 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 176280001732 CoenzymeA binding site [chemical binding]; other site 176280001733 subunit interaction site [polypeptide binding]; other site 176280001734 PHB binding site; other site 176280001735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176280001736 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176280001737 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 176280001738 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 176280001739 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 176280001740 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 176280001741 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176280001742 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 176280001743 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 176280001744 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 176280001745 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 176280001746 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176280001747 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 176280001748 Kinase associated protein B; Region: KapB; pfam08810 176280001749 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 176280001750 active site 176280001751 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 176280001752 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 176280001753 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 176280001754 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 176280001755 putative active site [active] 176280001756 putative FMN binding site [chemical binding]; other site 176280001757 putative substrate binding site [chemical binding]; other site 176280001758 putative catalytic residue [active] 176280001759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 176280001760 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 176280001761 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 176280001762 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176280001763 inhibitor-cofactor binding pocket; inhibition site 176280001764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280001765 catalytic residue [active] 176280001766 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 176280001767 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 176280001768 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 176280001769 NAD(P) binding site [chemical binding]; other site 176280001770 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 176280001771 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 176280001772 active site 176280001773 catalytic site [active] 176280001774 metal binding site [ion binding]; metal-binding site 176280001775 argininosuccinate lyase; Provisional; Region: PRK00855 176280001776 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 176280001777 active sites [active] 176280001778 tetramer interface [polypeptide binding]; other site 176280001779 argininosuccinate synthase; Provisional; Region: PRK13820 176280001780 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 176280001781 ANP binding site [chemical binding]; other site 176280001782 Substrate Binding Site II [chemical binding]; other site 176280001783 Substrate Binding Site I [chemical binding]; other site 176280001784 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 176280001785 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 176280001786 active site 176280001787 dimer interface [polypeptide binding]; other site 176280001788 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 176280001789 dimer interface [polypeptide binding]; other site 176280001790 active site 176280001791 Uncharacterized conserved protein [Function unknown]; Region: COG0398 176280001792 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 176280001793 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 176280001794 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 176280001795 Catalytic site [active] 176280001796 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 176280001797 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 176280001798 Catalytic site [active] 176280001799 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 176280001800 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 176280001801 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 176280001802 Family description; Region: UvrD_C_2; pfam13538 176280001803 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 176280001804 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 176280001805 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 176280001806 hypothetical protein; Provisional; Region: PRK13673 176280001807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280001808 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280001809 coenzyme A disulfide reductase; Provisional; Region: PRK13512 176280001810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176280001811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280001812 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280001813 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 176280001814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280001815 active site 176280001816 motif I; other site 176280001817 motif II; other site 176280001818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280001819 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 176280001820 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 176280001821 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 176280001822 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 176280001823 catalytic triad [active] 176280001824 catalytic triad [active] 176280001825 oxyanion hole [active] 176280001826 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 176280001827 Clp amino terminal domain; Region: Clp_N; pfam02861 176280001828 Clp amino terminal domain; Region: Clp_N; pfam02861 176280001829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280001830 Walker A motif; other site 176280001831 ATP binding site [chemical binding]; other site 176280001832 Walker B motif; other site 176280001833 arginine finger; other site 176280001834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280001835 Walker A motif; other site 176280001836 ATP binding site [chemical binding]; other site 176280001837 Walker B motif; other site 176280001838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 176280001839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280001840 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280001841 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 176280001842 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 176280001843 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 176280001844 dimer interface [polypeptide binding]; other site 176280001845 active site 176280001846 CoA binding pocket [chemical binding]; other site 176280001847 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 176280001848 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 176280001849 dimer interface [polypeptide binding]; other site 176280001850 active site 176280001851 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 176280001852 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 176280001853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280001854 dimer interface [polypeptide binding]; other site 176280001855 conserved gate region; other site 176280001856 putative PBP binding loops; other site 176280001857 ABC-ATPase subunit interface; other site 176280001858 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 176280001859 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 176280001860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280001861 dimer interface [polypeptide binding]; other site 176280001862 conserved gate region; other site 176280001863 putative PBP binding loops; other site 176280001864 ABC-ATPase subunit interface; other site 176280001865 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 176280001866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176280001867 Walker A/P-loop; other site 176280001868 ATP binding site [chemical binding]; other site 176280001869 Q-loop/lid; other site 176280001870 ABC transporter signature motif; other site 176280001871 Walker B; other site 176280001872 D-loop; other site 176280001873 H-loop/switch region; other site 176280001874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 176280001875 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 176280001876 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176280001877 Walker A/P-loop; other site 176280001878 ATP binding site [chemical binding]; other site 176280001879 Q-loop/lid; other site 176280001880 ABC transporter signature motif; other site 176280001881 Walker B; other site 176280001882 D-loop; other site 176280001883 H-loop/switch region; other site 176280001884 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 176280001885 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 176280001886 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 176280001887 peptide binding site [polypeptide binding]; other site 176280001888 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 176280001889 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 176280001890 active site 176280001891 HIGH motif; other site 176280001892 dimer interface [polypeptide binding]; other site 176280001893 KMSKS motif; other site 176280001894 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 176280001895 ArsC family; Region: ArsC; pfam03960 176280001896 putative catalytic residues [active] 176280001897 thiol/disulfide switch; other site 176280001898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280001899 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280001900 adaptor protein; Provisional; Region: PRK02315 176280001901 Competence protein CoiA-like family; Region: CoiA; pfam06054 176280001902 oligoendopeptidase F; Region: pepF; TIGR00181 176280001903 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 176280001904 active site 176280001905 Zn binding site [ion binding]; other site 176280001906 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 176280001907 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 176280001908 catalytic residues [active] 176280001909 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 176280001910 apolar tunnel; other site 176280001911 heme binding site [chemical binding]; other site 176280001912 dimerization interface [polypeptide binding]; other site 176280001913 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 176280001914 putative active site [active] 176280001915 putative metal binding residues [ion binding]; other site 176280001916 signature motif; other site 176280001917 putative triphosphate binding site [ion binding]; other site 176280001918 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 176280001919 synthetase active site [active] 176280001920 NTP binding site [chemical binding]; other site 176280001921 metal binding site [ion binding]; metal-binding site 176280001922 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 176280001923 ATP-NAD kinase; Region: NAD_kinase; pfam01513 176280001924 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 176280001925 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 176280001926 active site 176280001927 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 176280001928 MgtE intracellular N domain; Region: MgtE_N; smart00924 176280001929 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 176280001930 Divalent cation transporter; Region: MgtE; pfam01769 176280001931 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 176280001932 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 176280001933 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 176280001934 TrkA-N domain; Region: TrkA_N; pfam02254 176280001935 TrkA-C domain; Region: TrkA_C; pfam02080 176280001936 Protein of unknown function (DUF443); Region: DUF443; pfam04276 176280001937 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 176280001938 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 176280001939 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 176280001940 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 176280001941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280001942 Walker A/P-loop; other site 176280001943 ATP binding site [chemical binding]; other site 176280001944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280001945 Q-loop/lid; other site 176280001946 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 176280001947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280001948 AAA domain; Region: AAA_21; pfam13304 176280001949 Walker A/P-loop; other site 176280001950 ATP binding site [chemical binding]; other site 176280001951 Q-loop/lid; other site 176280001952 ABC transporter signature motif; other site 176280001953 Walker B; other site 176280001954 D-loop; other site 176280001955 H-loop/switch region; other site 176280001956 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 176280001957 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 176280001958 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 176280001959 catalytic residues [active] 176280001960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 176280001961 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 176280001962 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 176280001963 NAD binding site [chemical binding]; other site 176280001964 homotetramer interface [polypeptide binding]; other site 176280001965 homodimer interface [polypeptide binding]; other site 176280001966 substrate binding site [chemical binding]; other site 176280001967 active site 176280001968 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 176280001969 Domain of unknown function DUF20; Region: UPF0118; pfam01594 176280001970 Putative esterase; Region: Esterase; pfam00756 176280001971 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 176280001972 hypothetical protein; Provisional; Region: PRK13679 176280001973 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 176280001974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280001975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280001976 putative substrate translocation pore; other site 176280001977 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 176280001978 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 176280001979 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 176280001980 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 176280001981 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 176280001982 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176280001983 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176280001984 YueH-like protein; Region: YueH; pfam14166 176280001985 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 176280001986 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 176280001987 G1 box; other site 176280001988 putative GEF interaction site [polypeptide binding]; other site 176280001989 GTP/Mg2+ binding site [chemical binding]; other site 176280001990 Switch I region; other site 176280001991 G2 box; other site 176280001992 G3 box; other site 176280001993 Switch II region; other site 176280001994 G4 box; other site 176280001995 G5 box; other site 176280001996 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 176280001997 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 176280001998 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 176280001999 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 176280002000 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 176280002001 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 176280002002 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 176280002003 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 176280002004 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 176280002005 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 176280002006 active site 176280002007 metal binding site [ion binding]; metal-binding site 176280002008 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 176280002009 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 176280002010 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 176280002011 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 176280002012 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 176280002013 ComK protein; Region: ComK; cl11560 176280002014 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 176280002015 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 176280002016 Fatty acid desaturase; Region: FA_desaturase; pfam00487 176280002017 LysE type translocator; Region: LysE; cl00565 176280002018 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 176280002019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280002020 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 176280002021 Coenzyme A binding pocket [chemical binding]; other site 176280002022 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 176280002023 UbiA prenyltransferase family; Region: UbiA; pfam01040 176280002024 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 176280002025 isochorismate synthases; Region: isochor_syn; TIGR00543 176280002026 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 176280002027 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 176280002028 dimer interface [polypeptide binding]; other site 176280002029 tetramer interface [polypeptide binding]; other site 176280002030 PYR/PP interface [polypeptide binding]; other site 176280002031 TPP binding site [chemical binding]; other site 176280002032 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 176280002033 TPP-binding site; other site 176280002034 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 176280002035 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 176280002036 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 176280002037 substrate binding site [chemical binding]; other site 176280002038 oxyanion hole (OAH) forming residues; other site 176280002039 trimer interface [polypeptide binding]; other site 176280002040 aminotransferase A; Validated; Region: PRK07683 176280002041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 176280002042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280002043 homodimer interface [polypeptide binding]; other site 176280002044 catalytic residue [active] 176280002045 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 176280002046 Acyltransferase family; Region: Acyl_transf_3; pfam01757 176280002047 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176280002048 MarR family; Region: MarR; pfam01047 176280002049 MarR family; Region: MarR_2; cl17246 176280002050 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 176280002051 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 176280002052 amidase catalytic site [active] 176280002053 Zn binding residues [ion binding]; other site 176280002054 substrate binding site [chemical binding]; other site 176280002055 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 176280002056 Lysozyme subfamily 2; Region: LYZ2; smart00047 176280002057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280002058 Coenzyme A binding pocket [chemical binding]; other site 176280002059 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 176280002060 Transcriptional regulator [Transcription]; Region: LytR; COG1316 176280002061 Beta-lactamase; Region: Beta-lactamase; pfam00144 176280002062 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 176280002063 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 176280002064 active site 176280002065 tetramer interface [polypeptide binding]; other site 176280002066 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 176280002067 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 176280002068 Subunit I/III interface [polypeptide binding]; other site 176280002069 Subunit III/IV interface [polypeptide binding]; other site 176280002070 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 176280002071 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 176280002072 D-pathway; other site 176280002073 Putative ubiquinol binding site [chemical binding]; other site 176280002074 Low-spin heme (heme b) binding site [chemical binding]; other site 176280002075 Putative water exit pathway; other site 176280002076 Binuclear center (heme o3/CuB) [ion binding]; other site 176280002077 K-pathway; other site 176280002078 Putative proton exit pathway; other site 176280002079 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 176280002080 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 176280002081 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 176280002082 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 176280002083 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 176280002084 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 176280002085 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 176280002086 homodimer interface [polypeptide binding]; other site 176280002087 NADP binding site [chemical binding]; other site 176280002088 substrate binding site [chemical binding]; other site 176280002089 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 176280002090 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 176280002091 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 176280002092 NAD binding site [chemical binding]; other site 176280002093 ATP-grasp domain; Region: ATP-grasp; pfam02222 176280002094 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 176280002095 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 176280002096 ATP binding site [chemical binding]; other site 176280002097 active site 176280002098 substrate binding site [chemical binding]; other site 176280002099 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 176280002100 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 176280002101 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 176280002102 putative active site [active] 176280002103 catalytic triad [active] 176280002104 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 176280002105 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 176280002106 dimerization interface [polypeptide binding]; other site 176280002107 ATP binding site [chemical binding]; other site 176280002108 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 176280002109 dimerization interface [polypeptide binding]; other site 176280002110 ATP binding site [chemical binding]; other site 176280002111 amidophosphoribosyltransferase; Provisional; Region: PRK07272 176280002112 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 176280002113 active site 176280002114 tetramer interface [polypeptide binding]; other site 176280002115 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176280002116 active site 176280002117 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 176280002118 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 176280002119 dimerization interface [polypeptide binding]; other site 176280002120 putative ATP binding site [chemical binding]; other site 176280002121 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 176280002122 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 176280002123 active site 176280002124 substrate binding site [chemical binding]; other site 176280002125 cosubstrate binding site; other site 176280002126 catalytic site [active] 176280002127 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 176280002128 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 176280002129 purine monophosphate binding site [chemical binding]; other site 176280002130 dimer interface [polypeptide binding]; other site 176280002131 putative catalytic residues [active] 176280002132 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 176280002133 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 176280002134 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 176280002135 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 176280002136 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 176280002137 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 176280002138 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 176280002139 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 176280002140 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 176280002141 Walker A/P-loop; other site 176280002142 ATP binding site [chemical binding]; other site 176280002143 Q-loop/lid; other site 176280002144 ABC transporter signature motif; other site 176280002145 Walker B; other site 176280002146 D-loop; other site 176280002147 H-loop/switch region; other site 176280002148 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 176280002149 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 176280002150 Walker A/P-loop; other site 176280002151 ATP binding site [chemical binding]; other site 176280002152 Q-loop/lid; other site 176280002153 ABC transporter signature motif; other site 176280002154 Walker B; other site 176280002155 D-loop; other site 176280002156 H-loop/switch region; other site 176280002157 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 176280002158 myosin-cross-reactive antigen; Provisional; Region: PRK13977 176280002159 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 176280002160 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 176280002161 putative RNA binding site [nucleotide binding]; other site 176280002162 Methyltransferase domain; Region: Methyltransf_26; pfam13659 176280002163 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 176280002164 dimerization domain swap beta strand [polypeptide binding]; other site 176280002165 regulatory protein interface [polypeptide binding]; other site 176280002166 active site 176280002167 regulatory phosphorylation site [posttranslational modification]; other site 176280002168 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 176280002169 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 176280002170 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 176280002171 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 176280002172 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 176280002173 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 176280002174 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 176280002175 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 176280002176 TrkA-N domain; Region: TrkA_N; pfam02254 176280002177 TrkA-C domain; Region: TrkA_C; pfam02080 176280002178 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 176280002179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 176280002180 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 176280002181 hypothetical protein; Provisional; Region: PRK13667 176280002182 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 176280002183 active site 176280002184 catalytic residues [active] 176280002185 metal binding site [ion binding]; metal-binding site 176280002186 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 176280002187 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 176280002188 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 176280002189 TPP-binding site [chemical binding]; other site 176280002190 tetramer interface [polypeptide binding]; other site 176280002191 heterodimer interface [polypeptide binding]; other site 176280002192 phosphorylation loop region [posttranslational modification] 176280002193 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 176280002194 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 176280002195 alpha subunit interface [polypeptide binding]; other site 176280002196 TPP binding site [chemical binding]; other site 176280002197 heterodimer interface [polypeptide binding]; other site 176280002198 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 176280002199 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 176280002200 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 176280002201 E3 interaction surface; other site 176280002202 lipoyl attachment site [posttranslational modification]; other site 176280002203 e3 binding domain; Region: E3_binding; pfam02817 176280002204 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 176280002205 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 176280002206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 176280002207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280002208 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280002209 hypothetical protein; Provisional; Region: PRK04387 176280002210 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 176280002211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176280002212 non-specific DNA binding site [nucleotide binding]; other site 176280002213 salt bridge; other site 176280002214 sequence-specific DNA binding site [nucleotide binding]; other site 176280002215 Cupin domain; Region: Cupin_2; pfam07883 176280002216 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 176280002217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280002218 Walker A/P-loop; other site 176280002219 ATP binding site [chemical binding]; other site 176280002220 Q-loop/lid; other site 176280002221 ABC transporter signature motif; other site 176280002222 Walker B; other site 176280002223 D-loop; other site 176280002224 H-loop/switch region; other site 176280002225 TOBE domain; Region: TOBE_2; pfam08402 176280002226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280002227 dimer interface [polypeptide binding]; other site 176280002228 conserved gate region; other site 176280002229 putative PBP binding loops; other site 176280002230 ABC-ATPase subunit interface; other site 176280002231 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 176280002232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280002233 dimer interface [polypeptide binding]; other site 176280002234 conserved gate region; other site 176280002235 putative PBP binding loops; other site 176280002236 ABC-ATPase subunit interface; other site 176280002237 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 176280002238 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 176280002239 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 176280002240 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 176280002241 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 176280002242 manganese transport protein MntH; Reviewed; Region: PRK00701 176280002243 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 176280002244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 176280002245 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 176280002246 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 176280002247 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 176280002248 active site 176280002249 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 176280002250 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 176280002251 G1 box; other site 176280002252 putative GEF interaction site [polypeptide binding]; other site 176280002253 GTP/Mg2+ binding site [chemical binding]; other site 176280002254 Switch I region; other site 176280002255 G2 box; other site 176280002256 G3 box; other site 176280002257 Switch II region; other site 176280002258 G4 box; other site 176280002259 G5 box; other site 176280002260 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 176280002261 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 176280002262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 176280002263 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 176280002264 hypothetical protein; Provisional; Region: PRK13666 176280002265 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 176280002266 pyruvate carboxylase; Reviewed; Region: PRK12999 176280002267 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176280002268 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 176280002269 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 176280002270 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 176280002271 active site 176280002272 catalytic residues [active] 176280002273 metal binding site [ion binding]; metal-binding site 176280002274 homodimer binding site [polypeptide binding]; other site 176280002275 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 176280002276 carboxyltransferase (CT) interaction site; other site 176280002277 biotinylation site [posttranslational modification]; other site 176280002278 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 176280002279 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 176280002280 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 176280002281 UbiA prenyltransferase family; Region: UbiA; pfam01040 176280002282 Protein of unknown function (DUF420); Region: DUF420; pfam04238 176280002283 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 176280002284 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 176280002285 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 176280002286 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 176280002287 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 176280002288 putative active site [active] 176280002289 catalytic site [active] 176280002290 putative metal binding site [ion binding]; other site 176280002291 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 176280002292 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 176280002293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280002294 S-adenosylmethionine binding site [chemical binding]; other site 176280002295 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 176280002296 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 176280002297 active site 176280002298 (T/H)XGH motif; other site 176280002299 hypothetical protein; Provisional; Region: PRK13670 176280002300 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 176280002301 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 176280002302 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 176280002303 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176280002304 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 176280002305 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 176280002306 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 176280002307 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 176280002308 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 176280002309 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 176280002310 dimer interface [polypeptide binding]; other site 176280002311 motif 1; other site 176280002312 active site 176280002313 motif 2; other site 176280002314 motif 3; other site 176280002315 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 176280002316 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 176280002317 putative tRNA-binding site [nucleotide binding]; other site 176280002318 B3/4 domain; Region: B3_4; pfam03483 176280002319 tRNA synthetase B5 domain; Region: B5; smart00874 176280002320 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 176280002321 dimer interface [polypeptide binding]; other site 176280002322 motif 1; other site 176280002323 motif 3; other site 176280002324 motif 2; other site 176280002325 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 176280002326 ribonuclease HIII; Provisional; Region: PRK00996 176280002327 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 176280002328 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 176280002329 RNA/DNA hybrid binding site [nucleotide binding]; other site 176280002330 active site 176280002331 Cell division protein ZapA; Region: ZapA; cl01146 176280002332 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 176280002333 Colicin V production protein; Region: Colicin_V; pfam02674 176280002334 hypothetical protein; Provisional; Region: PRK08609 176280002335 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 176280002336 active site 176280002337 primer binding site [nucleotide binding]; other site 176280002338 NTP binding site [chemical binding]; other site 176280002339 metal binding triad [ion binding]; metal-binding site 176280002340 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 176280002341 active site 176280002342 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 176280002343 MutS domain III; Region: MutS_III; pfam05192 176280002344 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 176280002345 Walker A/P-loop; other site 176280002346 ATP binding site [chemical binding]; other site 176280002347 Q-loop/lid; other site 176280002348 ABC transporter signature motif; other site 176280002349 Walker B; other site 176280002350 D-loop; other site 176280002351 H-loop/switch region; other site 176280002352 BRE1 E3 ubiquitin ligase; Region: BRE1; pfam08647 176280002353 Smr domain; Region: Smr; pfam01713 176280002354 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176280002355 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 176280002356 catalytic residues [active] 176280002357 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 176280002358 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 176280002359 GIY-YIG motif/motif A; other site 176280002360 active site 176280002361 catalytic site [active] 176280002362 putative DNA binding site [nucleotide binding]; other site 176280002363 metal binding site [ion binding]; metal-binding site 176280002364 UvrB/uvrC motif; Region: UVR; pfam02151 176280002365 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 176280002366 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 176280002367 putative Iron-sulfur protein interface [polypeptide binding]; other site 176280002368 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 176280002369 proximal heme binding site [chemical binding]; other site 176280002370 distal heme binding site [chemical binding]; other site 176280002371 putative dimer interface [polypeptide binding]; other site 176280002372 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 176280002373 L-aspartate oxidase; Provisional; Region: PRK06175 176280002374 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 176280002375 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 176280002376 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 176280002377 glutamate racemase; Provisional; Region: PRK00865 176280002378 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 176280002379 active site 176280002380 dimerization interface [polypeptide binding]; other site 176280002381 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 176280002382 active site 176280002383 metal binding site [ion binding]; metal-binding site 176280002384 homotetramer interface [polypeptide binding]; other site 176280002385 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176280002386 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176280002387 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176280002388 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176280002389 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 176280002390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280002391 motif II; other site 176280002392 hypothetical protein; Provisional; Region: PRK13688 176280002393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280002394 Coenzyme A binding pocket [chemical binding]; other site 176280002395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 176280002396 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 176280002397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 176280002398 MraZ protein; Region: MraZ; pfam02381 176280002399 MraZ protein; Region: MraZ; pfam02381 176280002400 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 176280002401 MraW methylase family; Region: Methyltransf_5; pfam01795 176280002402 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 176280002403 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 176280002404 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 176280002405 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 176280002406 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 176280002407 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 176280002408 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 176280002409 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 176280002410 Mg++ binding site [ion binding]; other site 176280002411 putative catalytic motif [active] 176280002412 putative substrate binding site [chemical binding]; other site 176280002413 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 176280002414 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176280002415 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176280002416 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 176280002417 Cell division protein FtsQ; Region: FtsQ; pfam03799 176280002418 cell division protein FtsA; Region: ftsA; TIGR01174 176280002419 Cell division protein FtsA; Region: FtsA; smart00842 176280002420 Cell division protein FtsA; Region: FtsA; pfam14450 176280002421 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 176280002422 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 176280002423 nucleotide binding site [chemical binding]; other site 176280002424 SulA interaction site; other site 176280002425 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 176280002426 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 176280002427 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 176280002428 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176280002429 catalytic residue [active] 176280002430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 176280002431 YGGT family; Region: YGGT; pfam02325 176280002432 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 176280002433 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176280002434 RNA binding surface [nucleotide binding]; other site 176280002435 DivIVA protein; Region: DivIVA; pfam05103 176280002436 DivIVA domain; Region: DivI1A_domain; TIGR03544 176280002437 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 176280002438 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 176280002439 HIGH motif; other site 176280002440 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 176280002441 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 176280002442 active site 176280002443 KMSKS motif; other site 176280002444 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 176280002445 tRNA binding surface [nucleotide binding]; other site 176280002446 anticodon binding site; other site 176280002447 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 176280002448 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 176280002449 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 176280002450 active site 176280002451 Surface antigen [General function prediction only]; Region: COG3942 176280002452 CHAP domain; Region: CHAP; pfam05257 176280002453 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 176280002454 lipoprotein signal peptidase; Provisional; Region: PRK14787 176280002455 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 176280002456 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176280002457 RNA binding surface [nucleotide binding]; other site 176280002458 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 176280002459 active site 176280002460 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 176280002461 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 176280002462 uracil transporter; Provisional; Region: PRK10720 176280002463 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 176280002464 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 176280002465 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 176280002466 dihydroorotase; Validated; Region: pyrC; PRK09357 176280002467 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 176280002468 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 176280002469 active site 176280002470 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 176280002471 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 176280002472 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 176280002473 catalytic site [active] 176280002474 subunit interface [polypeptide binding]; other site 176280002475 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 176280002476 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176280002477 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 176280002478 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 176280002479 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176280002480 ATP-grasp domain; Region: ATP-grasp_4; cl17255 176280002481 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 176280002482 IMP binding site; other site 176280002483 dimer interface [polypeptide binding]; other site 176280002484 interdomain contacts; other site 176280002485 partial ornithine binding site; other site 176280002486 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 176280002487 active site 176280002488 dimer interface [polypeptide binding]; other site 176280002489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176280002490 active site 176280002491 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 176280002492 dimer interface [polypeptide binding]; other site 176280002493 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 176280002494 Domain of unknown function (DUF814); Region: DUF814; pfam05670 176280002495 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 176280002496 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 176280002497 catalytic site [active] 176280002498 G-X2-G-X-G-K; other site 176280002499 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 176280002500 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 176280002501 Flavoprotein; Region: Flavoprotein; pfam02441 176280002502 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 176280002503 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 176280002504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176280002505 ATP binding site [chemical binding]; other site 176280002506 putative Mg++ binding site [ion binding]; other site 176280002507 helicase superfamily c-terminal domain; Region: HELICc; smart00490 176280002508 nucleotide binding region [chemical binding]; other site 176280002509 ATP-binding site [chemical binding]; other site 176280002510 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 176280002511 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 176280002512 active site 176280002513 catalytic residues [active] 176280002514 metal binding site [ion binding]; metal-binding site 176280002515 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 176280002516 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 176280002517 putative active site [active] 176280002518 substrate binding site [chemical binding]; other site 176280002519 putative cosubstrate binding site; other site 176280002520 catalytic site [active] 176280002521 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 176280002522 substrate binding site [chemical binding]; other site 176280002523 16S rRNA methyltransferase B; Provisional; Region: PRK14902 176280002524 NusB family; Region: NusB; pfam01029 176280002525 putative RNA binding site [nucleotide binding]; other site 176280002526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280002527 S-adenosylmethionine binding site [chemical binding]; other site 176280002528 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 176280002529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280002530 FeS/SAM binding site; other site 176280002531 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 176280002532 Protein phosphatase 2C; Region: PP2C; pfam00481 176280002533 active site 176280002534 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 176280002535 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 176280002536 active site 176280002537 ATP binding site [chemical binding]; other site 176280002538 substrate binding site [chemical binding]; other site 176280002539 activation loop (A-loop); other site 176280002540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 176280002541 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 176280002542 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 176280002543 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 176280002544 GTPase RsgA; Reviewed; Region: PRK00098 176280002545 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 176280002546 RNA binding site [nucleotide binding]; other site 176280002547 homodimer interface [polypeptide binding]; other site 176280002548 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 176280002549 GTPase/Zn-binding domain interface [polypeptide binding]; other site 176280002550 GTP/Mg2+ binding site [chemical binding]; other site 176280002551 G4 box; other site 176280002552 G5 box; other site 176280002553 G1 box; other site 176280002554 Switch I region; other site 176280002555 G2 box; other site 176280002556 G3 box; other site 176280002557 Switch II region; other site 176280002558 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 176280002559 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 176280002560 substrate binding site [chemical binding]; other site 176280002561 hexamer interface [polypeptide binding]; other site 176280002562 metal binding site [ion binding]; metal-binding site 176280002563 Thiamine pyrophosphokinase; Region: TPK; cd07995 176280002564 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 176280002565 active site 176280002566 dimerization interface [polypeptide binding]; other site 176280002567 thiamine binding site [chemical binding]; other site 176280002568 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 176280002569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 176280002570 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 176280002571 DAK2 domain; Region: Dak2; pfam02734 176280002572 RimM N-terminal domain; Region: RimM; pfam01782 176280002573 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 176280002574 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 176280002575 generic binding surface II; other site 176280002576 ssDNA binding site; other site 176280002577 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176280002578 ATP binding site [chemical binding]; other site 176280002579 putative Mg++ binding site [ion binding]; other site 176280002580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280002581 nucleotide binding region [chemical binding]; other site 176280002582 ATP-binding site [chemical binding]; other site 176280002583 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 176280002584 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 176280002585 putative phosphate acyltransferase; Provisional; Region: PRK05331 176280002586 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 176280002587 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 176280002588 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 176280002589 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 176280002590 NAD(P) binding site [chemical binding]; other site 176280002591 homotetramer interface [polypeptide binding]; other site 176280002592 homodimer interface [polypeptide binding]; other site 176280002593 active site 176280002594 acyl carrier protein; Provisional; Region: acpP; PRK00982 176280002595 ribonuclease III; Reviewed; Region: rnc; PRK00102 176280002596 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 176280002597 dimerization interface [polypeptide binding]; other site 176280002598 active site 176280002599 metal binding site [ion binding]; metal-binding site 176280002600 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 176280002601 dsRNA binding site [nucleotide binding]; other site 176280002602 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 176280002603 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 176280002604 Walker A/P-loop; other site 176280002605 ATP binding site [chemical binding]; other site 176280002606 Q-loop/lid; other site 176280002607 Mis12-Mtw1 protein family; Region: Mis12_component; pfam08202 176280002608 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 176280002609 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 176280002610 ABC transporter signature motif; other site 176280002611 Walker B; other site 176280002612 D-loop; other site 176280002613 H-loop/switch region; other site 176280002614 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 176280002615 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 176280002616 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 176280002617 P loop; other site 176280002618 GTP binding site [chemical binding]; other site 176280002619 putative DNA-binding protein; Validated; Region: PRK00118 176280002620 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 176280002621 signal recognition particle protein; Provisional; Region: PRK10867 176280002622 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 176280002623 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 176280002624 P loop; other site 176280002625 GTP binding site [chemical binding]; other site 176280002626 Signal peptide binding domain; Region: SRP_SPB; pfam02978 176280002627 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 176280002628 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 176280002629 RimM N-terminal domain; Region: RimM; pfam01782 176280002630 PRC-barrel domain; Region: PRC; pfam05239 176280002631 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 176280002632 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 176280002633 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 176280002634 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 176280002635 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 176280002636 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 176280002637 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 176280002638 GTP/Mg2+ binding site [chemical binding]; other site 176280002639 G4 box; other site 176280002640 G5 box; other site 176280002641 G1 box; other site 176280002642 Switch I region; other site 176280002643 G2 box; other site 176280002644 G3 box; other site 176280002645 Switch II region; other site 176280002646 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 176280002647 RNA/DNA hybrid binding site [nucleotide binding]; other site 176280002648 active site 176280002649 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 176280002650 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 176280002651 CoA-ligase; Region: Ligase_CoA; pfam00549 176280002652 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 176280002653 CoA binding domain; Region: CoA_binding; smart00881 176280002654 CoA-ligase; Region: Ligase_CoA; pfam00549 176280002655 DNA protecting protein DprA; Region: dprA; TIGR00732 176280002656 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 176280002657 DNA topoisomerase I; Validated; Region: PRK05582 176280002658 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 176280002659 active site 176280002660 interdomain interaction site; other site 176280002661 putative metal-binding site [ion binding]; other site 176280002662 nucleotide binding site [chemical binding]; other site 176280002663 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 176280002664 domain I; other site 176280002665 DNA binding groove [nucleotide binding] 176280002666 phosphate binding site [ion binding]; other site 176280002667 domain II; other site 176280002668 domain III; other site 176280002669 nucleotide binding site [chemical binding]; other site 176280002670 catalytic site [active] 176280002671 domain IV; other site 176280002672 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 176280002673 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 176280002674 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 176280002675 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 176280002676 Glucose inhibited division protein A; Region: GIDA; pfam01134 176280002677 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 176280002678 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 176280002679 active site 176280002680 DNA binding site [nucleotide binding] 176280002681 Int/Topo IB signature motif; other site 176280002682 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 176280002683 active site 176280002684 HslU subunit interaction site [polypeptide binding]; other site 176280002685 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 176280002686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280002687 Walker A motif; other site 176280002688 ATP binding site [chemical binding]; other site 176280002689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280002690 Walker B motif; other site 176280002691 arginine finger; other site 176280002692 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 176280002693 transcriptional repressor CodY; Validated; Region: PRK04158 176280002694 CodY GAF-like domain; Region: CodY; pfam06018 176280002695 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 176280002696 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 176280002697 rRNA interaction site [nucleotide binding]; other site 176280002698 S8 interaction site; other site 176280002699 putative laminin-1 binding site; other site 176280002700 elongation factor Ts; Provisional; Region: tsf; PRK09377 176280002701 UBA/TS-N domain; Region: UBA; pfam00627 176280002702 Elongation factor TS; Region: EF_TS; pfam00889 176280002703 Elongation factor TS; Region: EF_TS; pfam00889 176280002704 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 176280002705 putative nucleotide binding site [chemical binding]; other site 176280002706 uridine monophosphate binding site [chemical binding]; other site 176280002707 homohexameric interface [polypeptide binding]; other site 176280002708 ribosome recycling factor; Reviewed; Region: frr; PRK00083 176280002709 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 176280002710 hinge region; other site 176280002711 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 176280002712 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 176280002713 catalytic residue [active] 176280002714 putative FPP diphosphate binding site; other site 176280002715 putative FPP binding hydrophobic cleft; other site 176280002716 dimer interface [polypeptide binding]; other site 176280002717 putative IPP diphosphate binding site; other site 176280002718 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 176280002719 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 176280002720 RIP metalloprotease RseP; Region: TIGR00054 176280002721 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 176280002722 active site 176280002723 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 176280002724 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 176280002725 protein binding site [polypeptide binding]; other site 176280002726 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 176280002727 putative substrate binding region [chemical binding]; other site 176280002728 prolyl-tRNA synthetase; Provisional; Region: PRK09194 176280002729 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 176280002730 dimer interface [polypeptide binding]; other site 176280002731 motif 1; other site 176280002732 active site 176280002733 motif 2; other site 176280002734 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 176280002735 putative deacylase active site [active] 176280002736 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 176280002737 active site 176280002738 motif 3; other site 176280002739 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 176280002740 anticodon binding site; other site 176280002741 DNA polymerase III PolC; Validated; Region: polC; PRK00448 176280002742 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 176280002743 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 176280002744 generic binding surface II; other site 176280002745 generic binding surface I; other site 176280002746 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 176280002747 active site 176280002748 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 176280002749 active site 176280002750 catalytic site [active] 176280002751 substrate binding site [chemical binding]; other site 176280002752 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 176280002753 ribosome maturation protein RimP; Reviewed; Region: PRK00092 176280002754 Sm and related proteins; Region: Sm_like; cl00259 176280002755 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 176280002756 putative oligomer interface [polypeptide binding]; other site 176280002757 putative RNA binding site [nucleotide binding]; other site 176280002758 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 176280002759 NusA N-terminal domain; Region: NusA_N; pfam08529 176280002760 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 176280002761 RNA binding site [nucleotide binding]; other site 176280002762 homodimer interface [polypeptide binding]; other site 176280002763 NusA-like KH domain; Region: KH_5; pfam13184 176280002764 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 176280002765 G-X-X-G motif; other site 176280002766 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 176280002767 putative RNA binding cleft [nucleotide binding]; other site 176280002768 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 176280002769 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 176280002770 translation initiation factor IF-2; Region: IF-2; TIGR00487 176280002771 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 176280002772 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 176280002773 G1 box; other site 176280002774 putative GEF interaction site [polypeptide binding]; other site 176280002775 GTP/Mg2+ binding site [chemical binding]; other site 176280002776 Switch I region; other site 176280002777 G2 box; other site 176280002778 G3 box; other site 176280002779 Switch II region; other site 176280002780 G4 box; other site 176280002781 G5 box; other site 176280002782 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 176280002783 Translation-initiation factor 2; Region: IF-2; pfam11987 176280002784 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 176280002785 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 176280002786 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 176280002787 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 176280002788 RNA binding site [nucleotide binding]; other site 176280002789 active site 176280002790 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 176280002791 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 176280002792 active site 176280002793 Riboflavin kinase; Region: Flavokinase; smart00904 176280002794 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 176280002795 16S/18S rRNA binding site [nucleotide binding]; other site 176280002796 S13e-L30e interaction site [polypeptide binding]; other site 176280002797 25S rRNA binding site [nucleotide binding]; other site 176280002798 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 176280002799 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 176280002800 RNase E interface [polypeptide binding]; other site 176280002801 trimer interface [polypeptide binding]; other site 176280002802 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 176280002803 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 176280002804 RNase E interface [polypeptide binding]; other site 176280002805 trimer interface [polypeptide binding]; other site 176280002806 active site 176280002807 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 176280002808 putative nucleic acid binding region [nucleotide binding]; other site 176280002809 G-X-X-G motif; other site 176280002810 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 176280002811 RNA binding site [nucleotide binding]; other site 176280002812 domain interface; other site 176280002813 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 176280002814 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 176280002815 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 176280002816 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 176280002817 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 176280002818 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 176280002819 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 176280002820 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 176280002821 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 176280002822 DNA-binding site [nucleotide binding]; DNA binding site 176280002823 UTRA domain; Region: UTRA; pfam07702 176280002824 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 176280002825 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 176280002826 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 176280002827 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 176280002828 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 176280002829 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 176280002830 classical (c) SDRs; Region: SDR_c; cd05233 176280002831 NAD(P) binding site [chemical binding]; other site 176280002832 active site 176280002833 ACT domain; Region: ACT; pfam01842 176280002834 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 176280002835 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 176280002836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176280002837 non-specific DNA binding site [nucleotide binding]; other site 176280002838 salt bridge; other site 176280002839 sequence-specific DNA binding site [nucleotide binding]; other site 176280002840 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 176280002841 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 176280002842 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 176280002843 MPT binding site; other site 176280002844 recombinase A; Provisional; Region: recA; PRK09354 176280002845 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 176280002846 hexamer interface [polypeptide binding]; other site 176280002847 Walker A motif; other site 176280002848 ATP binding site [chemical binding]; other site 176280002849 Walker B motif; other site 176280002850 phosphodiesterase; Provisional; Region: PRK12704 176280002851 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176280002852 Zn2+ binding site [ion binding]; other site 176280002853 Mg2+ binding site [ion binding]; other site 176280002854 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 176280002855 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 176280002856 putative active site [active] 176280002857 metal binding site [ion binding]; metal-binding site 176280002858 homodimer binding site [polypeptide binding]; other site 176280002859 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 176280002860 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 176280002861 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 176280002862 dimer interface [polypeptide binding]; other site 176280002863 PYR/PP interface [polypeptide binding]; other site 176280002864 TPP binding site [chemical binding]; other site 176280002865 substrate binding site [chemical binding]; other site 176280002866 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 176280002867 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 176280002868 TPP-binding site [chemical binding]; other site 176280002869 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 176280002870 Protein of unknown function (DUF867); Region: DUF867; pfam05908 176280002871 Uncharacterized conserved protein [Function unknown]; Region: COG0011 176280002872 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 176280002873 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 176280002874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280002875 FeS/SAM binding site; other site 176280002876 TRAM domain; Region: TRAM; pfam01938 176280002877 Predicted membrane protein [Function unknown]; Region: COG4550 176280002878 thiW protein; Region: thiW; TIGR02359 176280002879 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 176280002880 MutS domain I; Region: MutS_I; pfam01624 176280002881 MutS domain II; Region: MutS_II; pfam05188 176280002882 MutS domain III; Region: MutS_III; pfam05192 176280002883 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 176280002884 Walker A/P-loop; other site 176280002885 ATP binding site [chemical binding]; other site 176280002886 Q-loop/lid; other site 176280002887 ABC transporter signature motif; other site 176280002888 Walker B; other site 176280002889 D-loop; other site 176280002890 H-loop/switch region; other site 176280002891 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 176280002892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280002893 ATP binding site [chemical binding]; other site 176280002894 Mg2+ binding site [ion binding]; other site 176280002895 G-X-G motif; other site 176280002896 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 176280002897 ATP binding site [chemical binding]; other site 176280002898 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 176280002899 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 176280002900 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 176280002901 amphipathic channel; other site 176280002902 Asn-Pro-Ala signature motifs; other site 176280002903 glycerol kinase; Provisional; Region: glpK; PRK00047 176280002904 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 176280002905 N- and C-terminal domain interface [polypeptide binding]; other site 176280002906 active site 176280002907 MgATP binding site [chemical binding]; other site 176280002908 catalytic site [active] 176280002909 metal binding site [ion binding]; metal-binding site 176280002910 glycerol binding site [chemical binding]; other site 176280002911 homotetramer interface [polypeptide binding]; other site 176280002912 homodimer interface [polypeptide binding]; other site 176280002913 FBP binding site [chemical binding]; other site 176280002914 protein IIAGlc interface [polypeptide binding]; other site 176280002915 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 176280002916 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 176280002917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 176280002918 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 176280002919 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 176280002920 bacterial Hfq-like; Region: Hfq; cd01716 176280002921 hexamer interface [polypeptide binding]; other site 176280002922 Sm1 motif; other site 176280002923 RNA binding site [nucleotide binding]; other site 176280002924 Sm2 motif; other site 176280002925 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 176280002926 catalytic residues [active] 176280002927 dimer interface [polypeptide binding]; other site 176280002928 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 176280002929 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 176280002930 HflX GTPase family; Region: HflX; cd01878 176280002931 G1 box; other site 176280002932 GTP/Mg2+ binding site [chemical binding]; other site 176280002933 Switch I region; other site 176280002934 G2 box; other site 176280002935 G3 box; other site 176280002936 Switch II region; other site 176280002937 G4 box; other site 176280002938 G5 box; other site 176280002939 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 176280002940 Aluminium resistance protein; Region: Alum_res; pfam06838 176280002941 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 176280002942 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 176280002943 DNA binding residues [nucleotide binding] 176280002944 putative dimer interface [polypeptide binding]; other site 176280002945 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 176280002946 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 176280002947 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 176280002948 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 176280002949 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 176280002950 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 176280002951 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 176280002952 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 176280002953 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 176280002954 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 176280002955 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 176280002956 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176280002957 catalytic residue [active] 176280002958 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 176280002959 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 176280002960 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 176280002961 putative active site [active] 176280002962 catalytic site [active] 176280002963 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 176280002964 putative active site [active] 176280002965 catalytic site [active] 176280002966 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 176280002967 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176280002968 Walker A/P-loop; other site 176280002969 ATP binding site [chemical binding]; other site 176280002970 Q-loop/lid; other site 176280002971 ABC transporter signature motif; other site 176280002972 Walker B; other site 176280002973 D-loop; other site 176280002974 H-loop/switch region; other site 176280002975 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 176280002976 ABC-2 type transporter; Region: ABC2_membrane; cl17235 176280002977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 176280002978 Histidine kinase; Region: HisKA_3; pfam07730 176280002979 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 176280002980 ATP binding site [chemical binding]; other site 176280002981 Mg2+ binding site [ion binding]; other site 176280002982 G-X-G motif; other site 176280002983 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 176280002984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280002985 active site 176280002986 phosphorylation site [posttranslational modification] 176280002987 intermolecular recognition site; other site 176280002988 dimerization interface [polypeptide binding]; other site 176280002989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 176280002990 DNA binding residues [nucleotide binding] 176280002991 dimerization interface [polypeptide binding]; other site 176280002992 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 176280002993 Staphylococcal nuclease homologues; Region: SNc; smart00318 176280002994 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 176280002995 Catalytic site; other site 176280002996 aspartate kinase; Reviewed; Region: PRK09034 176280002997 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 176280002998 putative catalytic residues [active] 176280002999 putative nucleotide binding site [chemical binding]; other site 176280003000 putative aspartate binding site [chemical binding]; other site 176280003001 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 176280003002 allosteric regulatory residue; other site 176280003003 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 176280003004 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 176280003005 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 176280003006 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 176280003007 threonine synthase; Reviewed; Region: PRK06721 176280003008 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 176280003009 homodimer interface [polypeptide binding]; other site 176280003010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280003011 catalytic residue [active] 176280003012 homoserine kinase; Provisional; Region: PRK01212 176280003013 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 176280003014 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 176280003015 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 176280003016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280003017 active site 176280003018 motif I; other site 176280003019 motif II; other site 176280003020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280003021 Transposase IS200 like; Region: Y1_Tnp; pfam01797 176280003022 lysine transporter; Provisional; Region: PRK10836 176280003023 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 176280003024 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 176280003025 tetramer interface [polypeptide binding]; other site 176280003026 heme binding pocket [chemical binding]; other site 176280003027 NADPH binding site [chemical binding]; other site 176280003028 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 176280003029 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 176280003030 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 176280003031 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 176280003032 active site 176280003033 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 176280003034 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 176280003035 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 176280003036 Catalytic site [active] 176280003037 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 176280003038 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 176280003039 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 176280003040 TPP-binding site [chemical binding]; other site 176280003041 dimer interface [polypeptide binding]; other site 176280003042 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 176280003043 PYR/PP interface [polypeptide binding]; other site 176280003044 dimer interface [polypeptide binding]; other site 176280003045 TPP binding site [chemical binding]; other site 176280003046 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 176280003047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 176280003048 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 176280003049 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 176280003050 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 176280003051 active site 176280003052 metal binding site [ion binding]; metal-binding site 176280003053 DNA binding site [nucleotide binding] 176280003054 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 176280003055 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 176280003056 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 176280003057 Walker A/P-loop; other site 176280003058 ATP binding site [chemical binding]; other site 176280003059 Q-loop/lid; other site 176280003060 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 176280003061 ABC transporter signature motif; other site 176280003062 Walker B; other site 176280003063 D-loop; other site 176280003064 H-loop/switch region; other site 176280003065 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 176280003066 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 176280003067 BCCT family transporter; Region: BCCT; pfam02028 176280003068 aconitate hydratase; Validated; Region: PRK09277 176280003069 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 176280003070 substrate binding site [chemical binding]; other site 176280003071 ligand binding site [chemical binding]; other site 176280003072 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 176280003073 substrate binding site [chemical binding]; other site 176280003074 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 176280003075 active site 176280003076 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 176280003077 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 176280003078 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 176280003079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280003080 ATP binding site [chemical binding]; other site 176280003081 Mg2+ binding site [ion binding]; other site 176280003082 G-X-G motif; other site 176280003083 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 176280003084 anchoring element; other site 176280003085 dimer interface [polypeptide binding]; other site 176280003086 ATP binding site [chemical binding]; other site 176280003087 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 176280003088 active site 176280003089 putative metal-binding site [ion binding]; other site 176280003090 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 176280003091 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 176280003092 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 176280003093 CAP-like domain; other site 176280003094 active site 176280003095 primary dimer interface [polypeptide binding]; other site 176280003096 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176280003097 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176280003098 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 176280003099 amino acid carrier protein; Region: agcS; TIGR00835 176280003100 CAT RNA binding domain; Region: CAT_RBD; smart01061 176280003101 transcriptional antiterminator BglG; Provisional; Region: PRK09772 176280003102 PRD domain; Region: PRD; pfam00874 176280003103 PRD domain; Region: PRD; pfam00874 176280003104 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 176280003105 Domain of unknown function DUF20; Region: UPF0118; pfam01594 176280003106 Predicted integral membrane protein [Function unknown]; Region: COG0392 176280003107 Uncharacterized conserved protein [Function unknown]; Region: COG2898 176280003108 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 176280003109 methionine sulfoxide reductase A; Provisional; Region: PRK14054 176280003110 Transcriptional regulator [Transcription]; Region: LytR; COG1316 176280003111 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 176280003112 active site 1 [active] 176280003113 dimer interface [polypeptide binding]; other site 176280003114 hexamer interface [polypeptide binding]; other site 176280003115 active site 2 [active] 176280003116 DNA polymerase IV; Reviewed; Region: PRK03103 176280003117 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 176280003118 active site 176280003119 DNA binding site [nucleotide binding] 176280003120 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 176280003121 prephenate dehydrogenase; Validated; Region: PRK06545 176280003122 prephenate dehydrogenase; Validated; Region: PRK08507 176280003123 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 176280003124 anthranilate synthase component I; Provisional; Region: PRK13567 176280003125 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 176280003126 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 176280003127 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 176280003128 Glutamine amidotransferase class-I; Region: GATase; pfam00117 176280003129 glutamine binding [chemical binding]; other site 176280003130 catalytic triad [active] 176280003131 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 176280003132 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 176280003133 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 176280003134 active site 176280003135 ribulose/triose binding site [chemical binding]; other site 176280003136 phosphate binding site [ion binding]; other site 176280003137 substrate (anthranilate) binding pocket [chemical binding]; other site 176280003138 product (indole) binding pocket [chemical binding]; other site 176280003139 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 176280003140 active site 176280003141 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 176280003142 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 176280003143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280003144 catalytic residue [active] 176280003145 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 176280003146 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 176280003147 substrate binding site [chemical binding]; other site 176280003148 active site 176280003149 catalytic residues [active] 176280003150 heterodimer interface [polypeptide binding]; other site 176280003151 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 176280003152 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 176280003153 potential catalytic triad [active] 176280003154 conserved cys residue [active] 176280003155 FemAB family; Region: FemAB; pfam02388 176280003156 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 176280003157 FemAB family; Region: FemAB; pfam02388 176280003158 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 176280003159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 176280003160 active site 176280003161 motif I; other site 176280003162 motif II; other site 176280003163 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 176280003164 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176280003165 Walker A/P-loop; other site 176280003166 ATP binding site [chemical binding]; other site 176280003167 Q-loop/lid; other site 176280003168 ABC transporter signature motif; other site 176280003169 Walker B; other site 176280003170 D-loop; other site 176280003171 H-loop/switch region; other site 176280003172 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 176280003173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176280003174 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 176280003175 Walker A/P-loop; other site 176280003176 ATP binding site [chemical binding]; other site 176280003177 Q-loop/lid; other site 176280003178 ABC transporter signature motif; other site 176280003179 Walker B; other site 176280003180 D-loop; other site 176280003181 H-loop/switch region; other site 176280003182 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 176280003183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280003184 dimer interface [polypeptide binding]; other site 176280003185 conserved gate region; other site 176280003186 putative PBP binding loops; other site 176280003187 ABC-ATPase subunit interface; other site 176280003188 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 176280003189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280003190 dimer interface [polypeptide binding]; other site 176280003191 conserved gate region; other site 176280003192 putative PBP binding loops; other site 176280003193 ABC-ATPase subunit interface; other site 176280003194 oligoendopeptidase F; Region: pepF; TIGR00181 176280003195 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 176280003196 active site 176280003197 Zn binding site [ion binding]; other site 176280003198 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 176280003199 PhoU domain; Region: PhoU; pfam01895 176280003200 PhoU domain; Region: PhoU; pfam01895 176280003201 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 176280003202 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 176280003203 Walker A/P-loop; other site 176280003204 ATP binding site [chemical binding]; other site 176280003205 Q-loop/lid; other site 176280003206 ABC transporter signature motif; other site 176280003207 Walker B; other site 176280003208 D-loop; other site 176280003209 H-loop/switch region; other site 176280003210 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 176280003211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280003212 dimer interface [polypeptide binding]; other site 176280003213 conserved gate region; other site 176280003214 putative PBP binding loops; other site 176280003215 ABC-ATPase subunit interface; other site 176280003216 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 176280003217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280003218 dimer interface [polypeptide binding]; other site 176280003219 conserved gate region; other site 176280003220 ABC-ATPase subunit interface; other site 176280003221 PBP superfamily domain; Region: PBP_like_2; cl17296 176280003222 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 176280003223 S1 domain; Region: S1_2; pfam13509 176280003224 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 176280003225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280003226 Walker A/P-loop; other site 176280003227 ATP binding site [chemical binding]; other site 176280003228 Q-loop/lid; other site 176280003229 ABC transporter signature motif; other site 176280003230 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176280003231 Walker B; other site 176280003232 D-loop; other site 176280003233 H-loop/switch region; other site 176280003234 ABC transporter; Region: ABC_tran_2; pfam12848 176280003235 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176280003236 aspartate kinase; Reviewed; Region: PRK06635 176280003237 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 176280003238 putative nucleotide binding site [chemical binding]; other site 176280003239 putative catalytic residues [active] 176280003240 putative Mg ion binding site [ion binding]; other site 176280003241 putative aspartate binding site [chemical binding]; other site 176280003242 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 176280003243 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 176280003244 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 176280003245 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 176280003246 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 176280003247 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 176280003248 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 176280003249 dimer interface [polypeptide binding]; other site 176280003250 active site 176280003251 catalytic residue [active] 176280003252 dihydrodipicolinate reductase; Provisional; Region: PRK00048 176280003253 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 176280003254 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 176280003255 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 176280003256 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 176280003257 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 176280003258 active site 176280003259 trimer interface [polypeptide binding]; other site 176280003260 substrate binding site [chemical binding]; other site 176280003261 CoA binding site [chemical binding]; other site 176280003262 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176280003263 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 176280003264 metal binding site [ion binding]; metal-binding site 176280003265 dimer interface [polypeptide binding]; other site 176280003266 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 176280003267 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 176280003268 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176280003269 catalytic residue [active] 176280003270 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 176280003271 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 176280003272 active site 176280003273 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176280003274 substrate binding site [chemical binding]; other site 176280003275 catalytic residues [active] 176280003276 dimer interface [polypeptide binding]; other site 176280003277 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 176280003278 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176280003279 Walker A/P-loop; other site 176280003280 ATP binding site [chemical binding]; other site 176280003281 Q-loop/lid; other site 176280003282 ABC transporter signature motif; other site 176280003283 Walker B; other site 176280003284 D-loop; other site 176280003285 H-loop/switch region; other site 176280003286 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 176280003287 DNA-binding site [nucleotide binding]; DNA binding site 176280003288 RNA-binding motif; other site 176280003289 acylphosphatase; Provisional; Region: PRK14431 176280003290 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 176280003291 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 176280003292 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 176280003293 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 176280003294 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 176280003295 metal ion-dependent adhesion site (MIDAS); other site 176280003296 MoxR-like ATPases [General function prediction only]; Region: COG0714 176280003297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280003298 Walker A motif; other site 176280003299 ATP binding site [chemical binding]; other site 176280003300 Walker B motif; other site 176280003301 arginine finger; other site 176280003302 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 176280003303 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 176280003304 active site 176280003305 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 176280003306 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 176280003307 E3 interaction surface; other site 176280003308 lipoyl attachment site [posttranslational modification]; other site 176280003309 e3 binding domain; Region: E3_binding; pfam02817 176280003310 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 176280003311 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 176280003312 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 176280003313 TPP-binding site [chemical binding]; other site 176280003314 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 176280003315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176280003316 HAMP domain; Region: HAMP; pfam00672 176280003317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176280003318 dimer interface [polypeptide binding]; other site 176280003319 phosphorylation site [posttranslational modification] 176280003320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280003321 ATP binding site [chemical binding]; other site 176280003322 Mg2+ binding site [ion binding]; other site 176280003323 G-X-G motif; other site 176280003324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176280003325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280003326 active site 176280003327 phosphorylation site [posttranslational modification] 176280003328 intermolecular recognition site; other site 176280003329 dimerization interface [polypeptide binding]; other site 176280003330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176280003331 DNA binding site [nucleotide binding] 176280003332 hypothetical protein; Provisional; Region: PRK01184 176280003333 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 176280003334 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 176280003335 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 176280003336 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 176280003337 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 176280003338 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 176280003339 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 176280003340 putative active site [active] 176280003341 putative metal binding site [ion binding]; other site 176280003342 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 176280003343 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 176280003344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280003345 dimer interface [polypeptide binding]; other site 176280003346 conserved gate region; other site 176280003347 putative PBP binding loops; other site 176280003348 ABC-ATPase subunit interface; other site 176280003349 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 176280003350 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 176280003351 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 176280003352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 176280003353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280003354 dimer interface [polypeptide binding]; other site 176280003355 ABC-ATPase subunit interface; other site 176280003356 putative PBP binding loops; other site 176280003357 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 176280003358 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 176280003359 Walker A/P-loop; other site 176280003360 ATP binding site [chemical binding]; other site 176280003361 Q-loop/lid; other site 176280003362 ABC transporter signature motif; other site 176280003363 Walker B; other site 176280003364 D-loop; other site 176280003365 H-loop/switch region; other site 176280003366 TOBE domain; Region: TOBE_2; pfam08402 176280003367 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 176280003368 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 176280003369 active site 176280003370 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 176280003371 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 176280003372 active site 176280003373 homodimer interface [polypeptide binding]; other site 176280003374 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 176280003375 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 176280003376 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 176280003377 C-terminal peptidase (prc); Region: prc; TIGR00225 176280003378 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 176280003379 protein binding site [polypeptide binding]; other site 176280003380 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 176280003381 Catalytic dyad [active] 176280003382 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 176280003383 hypothetical protein; Provisional; Region: PRK13672 176280003384 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 176280003385 HPr interaction site; other site 176280003386 glycerol kinase (GK) interaction site [polypeptide binding]; other site 176280003387 active site 176280003388 phosphorylation site [posttranslational modification] 176280003389 methionine sulfoxide reductase B; Provisional; Region: PRK00222 176280003390 SelR domain; Region: SelR; pfam01641 176280003391 methionine sulfoxide reductase A; Provisional; Region: PRK13014 176280003392 EDD domain protein, DegV family; Region: DegV; TIGR00762 176280003393 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 176280003394 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 176280003395 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 176280003396 folate binding site [chemical binding]; other site 176280003397 NADP+ binding site [chemical binding]; other site 176280003398 thymidylate synthase; Region: thym_sym; TIGR03284 176280003399 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 176280003400 dimerization interface [polypeptide binding]; other site 176280003401 active site 176280003402 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176280003403 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176280003404 Walker A/P-loop; other site 176280003405 ATP binding site [chemical binding]; other site 176280003406 Q-loop/lid; other site 176280003407 ABC transporter signature motif; other site 176280003408 Walker B; other site 176280003409 D-loop; other site 176280003410 H-loop/switch region; other site 176280003411 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 176280003412 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 176280003413 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 176280003414 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 176280003415 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 176280003416 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 176280003417 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 176280003418 RNA/DNA hybrid binding site [nucleotide binding]; other site 176280003419 active site 176280003420 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 176280003421 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 176280003422 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 176280003423 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 176280003424 GA module; Region: GA; smart00844 176280003425 GA module; Region: GA; smart00844 176280003426 GA module; Region: GA; smart00844 176280003427 GA module; Region: GA; smart00844 176280003428 GA module; Region: GA; smart00844 176280003429 GA module; Region: GA; pfam01468 176280003430 GA module; Region: GA; smart00844 176280003431 GA module; Region: GA; smart00844 176280003432 GA module; Region: GA; smart00844 176280003433 GA module; Region: GA; pfam01468 176280003434 GA module; Region: GA; smart00844 176280003435 GA module; Region: GA; smart00844 176280003436 GA module; Region: GA; smart00844 176280003437 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 176280003438 GA module; Region: GA; smart00844 176280003439 GA module; Region: GA; smart00844 176280003440 GA module; Region: GA; smart00844 176280003441 GA module; Region: GA; smart00844 176280003442 GA module; Region: GA; smart00844 176280003443 Predicted membrane protein [Function unknown]; Region: COG1511 176280003444 GA module; Region: GA; smart00844 176280003445 GA module; Region: GA; smart00844 176280003446 GA module; Region: GA; pfam01468 176280003447 GA module; Region: GA; smart00844 176280003448 GA module; Region: GA; smart00844 176280003449 GA module; Region: GA; smart00844 176280003450 GA module; Region: GA; smart00844 176280003451 GA module; Region: GA; smart00844 176280003452 GA module; Region: GA; pfam01468 176280003453 GA module; Region: GA; smart00844 176280003454 GA module; Region: GA; smart00844 176280003455 GA module; Region: GA; pfam01468 176280003456 GA module; Region: GA; smart00844 176280003457 GA module; Region: GA; smart00844 176280003458 GA module; Region: GA; smart00844 176280003459 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280003460 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280003461 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176280003462 5'-3' exonuclease; Region: 53EXOc; smart00475 176280003463 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 176280003464 active site 176280003465 metal binding site 1 [ion binding]; metal-binding site 176280003466 putative 5' ssDNA interaction site; other site 176280003467 metal binding site 3; metal-binding site 176280003468 metal binding site 2 [ion binding]; metal-binding site 176280003469 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 176280003470 putative DNA binding site [nucleotide binding]; other site 176280003471 putative metal binding site [ion binding]; other site 176280003472 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 176280003473 Dynamin family; Region: Dynamin_N; pfam00350 176280003474 G1 box; other site 176280003475 GTP/Mg2+ binding site [chemical binding]; other site 176280003476 G2 box; other site 176280003477 Switch I region; other site 176280003478 G3 box; other site 176280003479 Switch II region; other site 176280003480 G4 box; other site 176280003481 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 176280003482 Dynamin family; Region: Dynamin_N; pfam00350 176280003483 G1 box; other site 176280003484 GTP/Mg2+ binding site [chemical binding]; other site 176280003485 G2 box; other site 176280003486 Switch I region; other site 176280003487 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 176280003488 G3 box; other site 176280003489 Switch II region; other site 176280003490 GTP/Mg2+ binding site [chemical binding]; other site 176280003491 G4 box; other site 176280003492 G5 box; other site 176280003493 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 176280003494 NADH(P)-binding; Region: NAD_binding_10; pfam13460 176280003495 putative NAD(P) binding site [chemical binding]; other site 176280003496 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 176280003497 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 176280003498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280003499 cell division protein GpsB; Provisional; Region: PRK14127 176280003500 DivIVA domain; Region: DivI1A_domain; TIGR03544 176280003501 hypothetical protein; Provisional; Region: PRK13660 176280003502 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 176280003503 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 176280003504 Transglycosylase; Region: Transgly; pfam00912 176280003505 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 176280003506 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 176280003507 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 176280003508 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 176280003509 minor groove reading motif; other site 176280003510 helix-hairpin-helix signature motif; other site 176280003511 substrate binding pocket [chemical binding]; other site 176280003512 active site 176280003513 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 176280003514 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 176280003515 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 176280003516 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 176280003517 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 176280003518 putative dimer interface [polypeptide binding]; other site 176280003519 putative anticodon binding site; other site 176280003520 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 176280003521 homodimer interface [polypeptide binding]; other site 176280003522 motif 1; other site 176280003523 motif 2; other site 176280003524 active site 176280003525 motif 3; other site 176280003526 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 176280003527 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 176280003528 active site 176280003529 catalytic site [active] 176280003530 substrate binding site [chemical binding]; other site 176280003531 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 176280003532 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 176280003533 Biotin operon repressor [Transcription]; Region: BirA; COG1654 176280003534 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 176280003535 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 176280003536 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 176280003537 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 176280003538 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 176280003539 active site 176280003540 NTP binding site [chemical binding]; other site 176280003541 metal binding triad [ion binding]; metal-binding site 176280003542 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 176280003543 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 176280003544 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 176280003545 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 176280003546 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 176280003547 homodimer interface [polypeptide binding]; other site 176280003548 metal binding site [ion binding]; metal-binding site 176280003549 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 176280003550 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 176280003551 Uncharacterized conserved protein [Function unknown]; Region: COG5582 176280003552 UPF0302 domain; Region: UPF0302; pfam08864 176280003553 A short protein domain of unknown function; Region: IDEAL; smart00914 176280003554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176280003555 binding surface 176280003556 TPR motif; other site 176280003557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176280003558 TPR motif; other site 176280003559 binding surface 176280003560 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 176280003561 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 176280003562 hinge; other site 176280003563 active site 176280003564 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 176280003565 active site 176280003566 dimer interface [polypeptide binding]; other site 176280003567 metal binding site [ion binding]; metal-binding site 176280003568 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 176280003569 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 176280003570 Tetramer interface [polypeptide binding]; other site 176280003571 active site 176280003572 FMN-binding site [chemical binding]; other site 176280003573 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 176280003574 active site 176280003575 multimer interface [polypeptide binding]; other site 176280003576 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 176280003577 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 176280003578 substrate binding pocket [chemical binding]; other site 176280003579 chain length determination region; other site 176280003580 substrate-Mg2+ binding site; other site 176280003581 catalytic residues [active] 176280003582 aspartate-rich region 1; other site 176280003583 active site lid residues [active] 176280003584 aspartate-rich region 2; other site 176280003585 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 176280003586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280003587 S-adenosylmethionine binding site [chemical binding]; other site 176280003588 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 176280003589 IHF dimer interface [polypeptide binding]; other site 176280003590 IHF - DNA interface [nucleotide binding]; other site 176280003591 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 176280003592 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 176280003593 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 176280003594 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 176280003595 GTP-binding protein Der; Reviewed; Region: PRK00093 176280003596 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 176280003597 G1 box; other site 176280003598 GTP/Mg2+ binding site [chemical binding]; other site 176280003599 Switch I region; other site 176280003600 G2 box; other site 176280003601 Switch II region; other site 176280003602 G3 box; other site 176280003603 G4 box; other site 176280003604 G5 box; other site 176280003605 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 176280003606 G1 box; other site 176280003607 GTP/Mg2+ binding site [chemical binding]; other site 176280003608 Switch I region; other site 176280003609 G2 box; other site 176280003610 G3 box; other site 176280003611 Switch II region; other site 176280003612 G4 box; other site 176280003613 G5 box; other site 176280003614 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 176280003615 RNA binding site [nucleotide binding]; other site 176280003616 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 176280003617 RNA binding site [nucleotide binding]; other site 176280003618 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 176280003619 RNA binding site [nucleotide binding]; other site 176280003620 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 176280003621 RNA binding site [nucleotide binding]; other site 176280003622 cytidylate kinase; Provisional; Region: cmk; PRK00023 176280003623 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 176280003624 CMP-binding site; other site 176280003625 The sites determining sugar specificity; other site 176280003626 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 176280003627 active site 176280003628 homotetramer interface [polypeptide binding]; other site 176280003629 homodimer interface [polypeptide binding]; other site 176280003630 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 176280003631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 176280003632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280003633 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176280003634 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 176280003635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176280003636 ATP binding site [chemical binding]; other site 176280003637 putative Mg++ binding site [ion binding]; other site 176280003638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280003639 nucleotide binding region [chemical binding]; other site 176280003640 ATP-binding site [chemical binding]; other site 176280003641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 176280003642 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 176280003643 Predicted membrane protein [Function unknown]; Region: COG3601 176280003644 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 176280003645 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 176280003646 dimerization interface [polypeptide binding]; other site 176280003647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176280003648 dimer interface [polypeptide binding]; other site 176280003649 phosphorylation site [posttranslational modification] 176280003650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280003651 ATP binding site [chemical binding]; other site 176280003652 Mg2+ binding site [ion binding]; other site 176280003653 G-X-G motif; other site 176280003654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176280003655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280003656 active site 176280003657 phosphorylation site [posttranslational modification] 176280003658 intermolecular recognition site; other site 176280003659 dimerization interface [polypeptide binding]; other site 176280003660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176280003661 DNA binding site [nucleotide binding] 176280003662 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 176280003663 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176280003664 RNA binding surface [nucleotide binding]; other site 176280003665 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 176280003666 active site 176280003667 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 176280003668 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 176280003669 Domain of unknown function (DUF309); Region: DUF309; pfam03745 176280003670 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 176280003671 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 176280003672 active site 176280003673 Int/Topo IB signature motif; other site 176280003674 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 176280003675 metal binding site 2 [ion binding]; metal-binding site 176280003676 putative DNA binding helix; other site 176280003677 metal binding site 1 [ion binding]; metal-binding site 176280003678 dimer interface [polypeptide binding]; other site 176280003679 structural Zn2+ binding site [ion binding]; other site 176280003680 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 176280003681 dimer interface [polypeptide binding]; other site 176280003682 ADP-ribose binding site [chemical binding]; other site 176280003683 active site 176280003684 nudix motif; other site 176280003685 metal binding site [ion binding]; metal-binding site 176280003686 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 176280003687 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 176280003688 active site 176280003689 catalytic tetrad [active] 176280003690 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 176280003691 classical (c) SDRs; Region: SDR_c; cd05233 176280003692 NAD(P) binding site [chemical binding]; other site 176280003693 active site 176280003694 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 176280003695 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 176280003696 ribonuclease Z; Region: RNase_Z; TIGR02651 176280003697 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 176280003698 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 176280003699 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 176280003700 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176280003701 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 176280003702 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 176280003703 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 176280003704 Ca binding site [ion binding]; other site 176280003705 active site 176280003706 catalytic site [active] 176280003707 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 176280003708 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 176280003709 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 176280003710 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 176280003711 peptidase T-like protein; Region: PepT-like; TIGR01883 176280003712 metal binding site [ion binding]; metal-binding site 176280003713 putative dimer interface [polypeptide binding]; other site 176280003714 Predicted membrane protein [Function unknown]; Region: COG4129 176280003715 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 176280003716 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 176280003717 Disulphide isomerase; Region: Disulph_isomer; pfam06491 176280003718 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 176280003719 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 176280003720 E3 interaction surface; other site 176280003721 lipoyl attachment site [posttranslational modification]; other site 176280003722 e3 binding domain; Region: E3_binding; pfam02817 176280003723 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 176280003724 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 176280003725 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 176280003726 alpha subunit interface [polypeptide binding]; other site 176280003727 TPP binding site [chemical binding]; other site 176280003728 heterodimer interface [polypeptide binding]; other site 176280003729 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 176280003730 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 176280003731 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 176280003732 tetramer interface [polypeptide binding]; other site 176280003733 TPP-binding site [chemical binding]; other site 176280003734 heterodimer interface [polypeptide binding]; other site 176280003735 phosphorylation loop region [posttranslational modification] 176280003736 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 176280003737 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 176280003738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280003739 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280003740 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 176280003741 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 176280003742 Walker A/P-loop; other site 176280003743 ATP binding site [chemical binding]; other site 176280003744 Q-loop/lid; other site 176280003745 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 176280003746 Q-loop/lid; other site 176280003747 ABC transporter signature motif; other site 176280003748 Walker B; other site 176280003749 D-loop; other site 176280003750 H-loop/switch region; other site 176280003751 arginine repressor; Provisional; Region: PRK04280 176280003752 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 176280003753 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 176280003754 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 176280003755 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 176280003756 substrate binding pocket [chemical binding]; other site 176280003757 chain length determination region; other site 176280003758 substrate-Mg2+ binding site; other site 176280003759 catalytic residues [active] 176280003760 aspartate-rich region 1; other site 176280003761 active site lid residues [active] 176280003762 aspartate-rich region 2; other site 176280003763 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 176280003764 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 176280003765 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 176280003766 generic binding surface II; other site 176280003767 generic binding surface I; other site 176280003768 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 176280003769 putative RNA binding site [nucleotide binding]; other site 176280003770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 176280003771 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 176280003772 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176280003773 ATP-grasp domain; Region: ATP-grasp_4; cl17255 176280003774 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 176280003775 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 176280003776 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 176280003777 carboxyltransferase (CT) interaction site; other site 176280003778 biotinylation site [posttranslational modification]; other site 176280003779 acetylornithine aminotransferase; Provisional; Region: PRK04260 176280003780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176280003781 inhibitor-cofactor binding pocket; inhibition site 176280003782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280003783 catalytic residue [active] 176280003784 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 176280003785 nucleotide binding site [chemical binding]; other site 176280003786 N-acetyl-L-glutamate binding site [chemical binding]; other site 176280003787 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 176280003788 heterotetramer interface [polypeptide binding]; other site 176280003789 active site pocket [active] 176280003790 cleavage site 176280003791 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 176280003792 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 176280003793 elongation factor P; Validated; Region: PRK00529 176280003794 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 176280003795 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 176280003796 RNA binding site [nucleotide binding]; other site 176280003797 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 176280003798 RNA binding site [nucleotide binding]; other site 176280003799 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 176280003800 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 176280003801 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 176280003802 active site 176280003803 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 176280003804 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176280003805 active site residue [active] 176280003806 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 176280003807 tetramer interface [polypeptide binding]; other site 176280003808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280003809 catalytic residue [active] 176280003810 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 176280003811 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 176280003812 tetramer interface [polypeptide binding]; other site 176280003813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280003814 catalytic residue [active] 176280003815 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 176280003816 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 176280003817 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 176280003818 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 176280003819 ADP binding site [chemical binding]; other site 176280003820 magnesium binding site [ion binding]; other site 176280003821 putative shikimate binding site; other site 176280003822 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 176280003823 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 176280003824 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 176280003825 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 176280003826 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 176280003827 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 176280003828 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 176280003829 Type II/IV secretion system protein; Region: T2SE; pfam00437 176280003830 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 176280003831 Walker A motif; other site 176280003832 ATP binding site [chemical binding]; other site 176280003833 Walker B motif; other site 176280003834 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 176280003835 Uncharacterized conserved protein [Function unknown]; Region: COG0011 176280003836 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 176280003837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 176280003838 nucleotide binding site [chemical binding]; other site 176280003839 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 176280003840 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 176280003841 Rhomboid family; Region: Rhomboid; pfam01694 176280003842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176280003843 binding surface 176280003844 TPR motif; other site 176280003845 TPR repeat; Region: TPR_11; pfam13414 176280003846 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 176280003847 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 176280003848 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 176280003849 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 176280003850 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 176280003851 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 176280003852 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 176280003853 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 176280003854 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 176280003855 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 176280003856 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 176280003857 metal binding site 2 [ion binding]; metal-binding site 176280003858 putative DNA binding helix; other site 176280003859 metal binding site 1 [ion binding]; metal-binding site 176280003860 dimer interface [polypeptide binding]; other site 176280003861 structural Zn2+ binding site [ion binding]; other site 176280003862 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 176280003863 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176280003864 ABC-ATPase subunit interface; other site 176280003865 dimer interface [polypeptide binding]; other site 176280003866 putative PBP binding regions; other site 176280003867 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 176280003868 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 176280003869 endonuclease IV; Provisional; Region: PRK01060 176280003870 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 176280003871 AP (apurinic/apyrimidinic) site pocket; other site 176280003872 DNA interaction; other site 176280003873 Metal-binding active site; metal-binding site 176280003874 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 176280003875 DEAD-like helicases superfamily; Region: DEXDc; smart00487 176280003876 ATP binding site [chemical binding]; other site 176280003877 Mg++ binding site [ion binding]; other site 176280003878 motif III; other site 176280003879 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280003880 nucleotide binding region [chemical binding]; other site 176280003881 ATP-binding site [chemical binding]; other site 176280003882 Uncharacterized conserved protein [Function unknown]; Region: COG0327 176280003883 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 176280003884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 176280003885 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 176280003886 Uncharacterized conserved protein [Function unknown]; Region: COG0327 176280003887 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 176280003888 Family of unknown function (DUF633); Region: DUF633; pfam04816 176280003889 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 176280003890 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 176280003891 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 176280003892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 176280003893 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 176280003894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 176280003895 DNA binding residues [nucleotide binding] 176280003896 DNA primase, catalytic core; Region: dnaG; TIGR01391 176280003897 CHC2 zinc finger; Region: zf-CHC2; pfam01807 176280003898 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 176280003899 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 176280003900 active site 176280003901 metal binding site [ion binding]; metal-binding site 176280003902 interdomain interaction site; other site 176280003903 PEP synthetase regulatory protein; Provisional; Region: PRK05339 176280003904 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 176280003905 FOG: CBS domain [General function prediction only]; Region: COG0517 176280003906 glycyl-tRNA synthetase; Provisional; Region: PRK04173 176280003907 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 176280003908 motif 1; other site 176280003909 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 176280003910 active site 176280003911 motif 2; other site 176280003912 motif 3; other site 176280003913 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 176280003914 anticodon binding site; other site 176280003915 DNA repair protein RecO; Region: reco; TIGR00613 176280003916 Recombination protein O N terminal; Region: RecO_N; pfam11967 176280003917 Recombination protein O C terminal; Region: RecO_C; pfam02565 176280003918 GTPase Era; Reviewed; Region: era; PRK00089 176280003919 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 176280003920 G1 box; other site 176280003921 GTP/Mg2+ binding site [chemical binding]; other site 176280003922 Switch I region; other site 176280003923 G2 box; other site 176280003924 Switch II region; other site 176280003925 G3 box; other site 176280003926 G4 box; other site 176280003927 G5 box; other site 176280003928 KH domain; Region: KH_2; pfam07650 176280003929 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 176280003930 active site 176280003931 catalytic motif [active] 176280003932 Zn binding site [ion binding]; other site 176280003933 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 176280003934 metal-binding heat shock protein; Provisional; Region: PRK00016 176280003935 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 176280003936 PhoH-like protein; Region: PhoH; pfam02562 176280003937 hypothetical protein; Provisional; Region: PRK13665 176280003938 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 176280003939 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 176280003940 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 176280003941 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 176280003942 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280003943 FeS/SAM binding site; other site 176280003944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 176280003945 RNA methyltransferase, RsmE family; Region: TIGR00046 176280003946 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 176280003947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280003948 S-adenosylmethionine binding site [chemical binding]; other site 176280003949 chaperone protein DnaJ; Provisional; Region: PRK14280 176280003950 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 176280003951 HSP70 interaction site [polypeptide binding]; other site 176280003952 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 176280003953 substrate binding site [polypeptide binding]; other site 176280003954 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 176280003955 Zn binding sites [ion binding]; other site 176280003956 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 176280003957 dimer interface [polypeptide binding]; other site 176280003958 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 176280003959 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 176280003960 nucleotide binding site [chemical binding]; other site 176280003961 NEF interaction site [polypeptide binding]; other site 176280003962 SBD interface [polypeptide binding]; other site 176280003963 heat shock protein GrpE; Provisional; Region: PRK14140 176280003964 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 176280003965 dimer interface [polypeptide binding]; other site 176280003966 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 176280003967 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 176280003968 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 176280003969 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 176280003970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280003971 FeS/SAM binding site; other site 176280003972 HemN C-terminal domain; Region: HemN_C; pfam06969 176280003973 GTP-binding protein LepA; Provisional; Region: PRK05433 176280003974 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 176280003975 G1 box; other site 176280003976 putative GEF interaction site [polypeptide binding]; other site 176280003977 GTP/Mg2+ binding site [chemical binding]; other site 176280003978 Switch I region; other site 176280003979 G2 box; other site 176280003980 G3 box; other site 176280003981 Switch II region; other site 176280003982 G4 box; other site 176280003983 G5 box; other site 176280003984 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 176280003985 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 176280003986 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 176280003987 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 176280003988 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 176280003989 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 176280003990 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 176280003991 Competence protein; Region: Competence; pfam03772 176280003992 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 176280003993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 176280003994 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 176280003995 catalytic motif [active] 176280003996 Zn binding site [ion binding]; other site 176280003997 SLBB domain; Region: SLBB; pfam10531 176280003998 comEA protein; Region: comE; TIGR01259 176280003999 Helix-hairpin-helix motif; Region: HHH; pfam00633 176280004000 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 176280004001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280004002 S-adenosylmethionine binding site [chemical binding]; other site 176280004003 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 176280004004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176280004005 Zn2+ binding site [ion binding]; other site 176280004006 Mg2+ binding site [ion binding]; other site 176280004007 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 176280004008 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 176280004009 active site 176280004010 (T/H)XGH motif; other site 176280004011 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 176280004012 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 176280004013 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 176280004014 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 176280004015 shikimate binding site; other site 176280004016 NAD(P) binding site [chemical binding]; other site 176280004017 GTPase YqeH; Provisional; Region: PRK13796 176280004018 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 176280004019 GTP/Mg2+ binding site [chemical binding]; other site 176280004020 G4 box; other site 176280004021 G5 box; other site 176280004022 G1 box; other site 176280004023 Switch I region; other site 176280004024 G2 box; other site 176280004025 G3 box; other site 176280004026 Switch II region; other site 176280004027 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 176280004028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280004029 active site 176280004030 motif I; other site 176280004031 motif II; other site 176280004032 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 176280004033 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 176280004034 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 176280004035 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 176280004036 putative active site [active] 176280004037 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176280004038 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 176280004039 ATP-grasp domain; Region: ATP-grasp_4; cl17255 176280004040 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 176280004041 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 176280004042 carboxyltransferase (CT) interaction site; other site 176280004043 biotinylation site [posttranslational modification]; other site 176280004044 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 176280004045 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 176280004046 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 176280004047 Transposase IS200 like; Region: Y1_Tnp; pfam01797 176280004048 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 176280004049 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 176280004050 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 176280004051 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 176280004052 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 176280004053 Sugar specificity; other site 176280004054 Pyrimidine base specificity; other site 176280004055 ATP-binding site [chemical binding]; other site 176280004056 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 176280004057 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 176280004058 Peptidase family U32; Region: Peptidase_U32; pfam01136 176280004059 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 176280004060 Peptidase family U32; Region: Peptidase_U32; pfam01136 176280004061 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 176280004062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280004063 S-adenosylmethionine binding site [chemical binding]; other site 176280004064 hypothetical protein; Provisional; Region: PRK13678 176280004065 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 176280004066 hypothetical protein; Provisional; Region: PRK05473 176280004067 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 176280004068 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 176280004069 motif 1; other site 176280004070 active site 176280004071 motif 2; other site 176280004072 motif 3; other site 176280004073 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 176280004074 DHHA1 domain; Region: DHHA1; pfam02272 176280004075 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 176280004076 AAA domain; Region: AAA_30; pfam13604 176280004077 Family description; Region: UvrD_C_2; pfam13538 176280004078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176280004079 binding surface 176280004080 TPR repeat; Region: TPR_11; pfam13414 176280004081 TPR motif; other site 176280004082 Tetratricopeptide repeat; Region: TPR_12; pfam13424 176280004083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176280004084 binding surface 176280004085 TPR motif; other site 176280004086 TPR repeat; Region: TPR_11; pfam13414 176280004087 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 176280004088 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 176280004089 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 176280004090 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 176280004091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176280004092 catalytic residue [active] 176280004093 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 176280004094 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 176280004095 Predicted transcriptional regulator [Transcription]; Region: COG1959 176280004096 Transcriptional regulator; Region: Rrf2; pfam02082 176280004097 recombination factor protein RarA; Reviewed; Region: PRK13342 176280004098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280004099 Walker A motif; other site 176280004100 ATP binding site [chemical binding]; other site 176280004101 Walker B motif; other site 176280004102 arginine finger; other site 176280004103 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 176280004104 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 176280004105 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 176280004106 putative ATP binding site [chemical binding]; other site 176280004107 putative substrate interface [chemical binding]; other site 176280004108 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 176280004109 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 176280004110 dimer interface [polypeptide binding]; other site 176280004111 anticodon binding site; other site 176280004112 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 176280004113 homodimer interface [polypeptide binding]; other site 176280004114 motif 1; other site 176280004115 active site 176280004116 motif 2; other site 176280004117 GAD domain; Region: GAD; pfam02938 176280004118 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 176280004119 motif 3; other site 176280004120 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 176280004121 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 176280004122 dimer interface [polypeptide binding]; other site 176280004123 motif 1; other site 176280004124 active site 176280004125 motif 2; other site 176280004126 motif 3; other site 176280004127 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 176280004128 anticodon binding site; other site 176280004129 Bacterial SH3 domain homologues; Region: SH3b; smart00287 176280004130 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 176280004131 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 176280004132 active site 176280004133 metal binding site [ion binding]; metal-binding site 176280004134 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 176280004135 putative active site [active] 176280004136 dimerization interface [polypeptide binding]; other site 176280004137 putative tRNAtyr binding site [nucleotide binding]; other site 176280004138 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 176280004139 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176280004140 Zn2+ binding site [ion binding]; other site 176280004141 Mg2+ binding site [ion binding]; other site 176280004142 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 176280004143 synthetase active site [active] 176280004144 NTP binding site [chemical binding]; other site 176280004145 metal binding site [ion binding]; metal-binding site 176280004146 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 176280004147 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 176280004148 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176280004149 active site 176280004150 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 176280004151 DHH family; Region: DHH; pfam01368 176280004152 DHHA1 domain; Region: DHHA1; pfam02272 176280004153 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 176280004154 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 176280004155 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 176280004156 Protein export membrane protein; Region: SecD_SecF; cl14618 176280004157 Protein export membrane protein; Region: SecD_SecF; pfam02355 176280004158 Preprotein translocase subunit; Region: YajC; pfam02699 176280004159 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 176280004160 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 176280004161 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 176280004162 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 176280004163 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 176280004164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280004165 Walker A motif; other site 176280004166 ATP binding site [chemical binding]; other site 176280004167 Walker B motif; other site 176280004168 arginine finger; other site 176280004169 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 176280004170 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 176280004171 RuvA N terminal domain; Region: RuvA_N; pfam01330 176280004172 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 176280004173 hypothetical protein; Provisional; Region: PRK04435 176280004174 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 176280004175 GTPase CgtA; Reviewed; Region: obgE; PRK12297 176280004176 GTP1/OBG; Region: GTP1_OBG; pfam01018 176280004177 Obg GTPase; Region: Obg; cd01898 176280004178 G1 box; other site 176280004179 GTP/Mg2+ binding site [chemical binding]; other site 176280004180 Switch I region; other site 176280004181 G2 box; other site 176280004182 G3 box; other site 176280004183 Switch II region; other site 176280004184 G4 box; other site 176280004185 G5 box; other site 176280004186 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 176280004187 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 176280004188 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 176280004189 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 176280004190 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 176280004191 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 176280004192 rod shape-determining protein MreC; Provisional; Region: PRK13922 176280004193 rod shape-determining protein MreC; Region: MreC; pfam04085 176280004194 hypothetical protein; Reviewed; Region: PRK00024 176280004195 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 176280004196 MPN+ (JAMM) motif; other site 176280004197 Zinc-binding site [ion binding]; other site 176280004198 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 176280004199 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 176280004200 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 176280004201 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176280004202 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176280004203 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 176280004204 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 176280004205 active site 176280004206 HIGH motif; other site 176280004207 nucleotide binding site [chemical binding]; other site 176280004208 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 176280004209 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 176280004210 active site 176280004211 KMSKS motif; other site 176280004212 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 176280004213 tRNA binding surface [nucleotide binding]; other site 176280004214 anticodon binding site; other site 176280004215 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 176280004216 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 176280004217 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 176280004218 Putative ammonia monooxygenase; Region: AmoA; pfam05145 176280004219 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 176280004220 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 176280004221 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176280004222 inhibitor-cofactor binding pocket; inhibition site 176280004223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280004224 catalytic residue [active] 176280004225 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 176280004226 dimer interface [polypeptide binding]; other site 176280004227 active site 176280004228 Schiff base residues; other site 176280004229 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 176280004230 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 176280004231 active site 176280004232 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 176280004233 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 176280004234 domain interfaces; other site 176280004235 active site 176280004236 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 176280004237 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 176280004238 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 176280004239 tRNA; other site 176280004240 putative tRNA binding site [nucleotide binding]; other site 176280004241 putative NADP binding site [chemical binding]; other site 176280004242 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 176280004243 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 176280004244 G1 box; other site 176280004245 GTP/Mg2+ binding site [chemical binding]; other site 176280004246 Switch I region; other site 176280004247 G2 box; other site 176280004248 G3 box; other site 176280004249 Switch II region; other site 176280004250 G4 box; other site 176280004251 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 176280004252 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 176280004253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280004254 Walker A motif; other site 176280004255 ATP binding site [chemical binding]; other site 176280004256 Walker B motif; other site 176280004257 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 176280004258 trigger factor; Provisional; Region: tig; PRK01490 176280004259 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 176280004260 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 176280004261 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 176280004262 active site 176280004263 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 176280004264 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 176280004265 23S rRNA binding site [nucleotide binding]; other site 176280004266 L21 binding site [polypeptide binding]; other site 176280004267 L13 binding site [polypeptide binding]; other site 176280004268 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 176280004269 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 176280004270 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 176280004271 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 176280004272 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 176280004273 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 176280004274 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 176280004275 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 176280004276 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 176280004277 active site 176280004278 dimer interface [polypeptide binding]; other site 176280004279 motif 1; other site 176280004280 motif 2; other site 176280004281 motif 3; other site 176280004282 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 176280004283 anticodon binding site; other site 176280004284 primosomal protein DnaI; Reviewed; Region: PRK08939 176280004285 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 176280004286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280004287 Walker A motif; other site 176280004288 ATP binding site [chemical binding]; other site 176280004289 Walker B motif; other site 176280004290 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 176280004291 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 176280004292 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 176280004293 ATP cone domain; Region: ATP-cone; pfam03477 176280004294 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 176280004295 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 176280004296 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 176280004297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 176280004298 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 176280004299 dephospho-CoA kinase; Region: TIGR00152 176280004300 CoA-binding site [chemical binding]; other site 176280004301 ATP-binding [chemical binding]; other site 176280004302 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 176280004303 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 176280004304 DNA binding site [nucleotide binding] 176280004305 catalytic residue [active] 176280004306 H2TH interface [polypeptide binding]; other site 176280004307 putative catalytic residues [active] 176280004308 turnover-facilitating residue; other site 176280004309 intercalation triad [nucleotide binding]; other site 176280004310 8OG recognition residue [nucleotide binding]; other site 176280004311 putative reading head residues; other site 176280004312 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 176280004313 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 176280004314 DNA polymerase I; Provisional; Region: PRK05755 176280004315 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 176280004316 active site 176280004317 metal binding site 1 [ion binding]; metal-binding site 176280004318 putative 5' ssDNA interaction site; other site 176280004319 metal binding site 3; metal-binding site 176280004320 metal binding site 2 [ion binding]; metal-binding site 176280004321 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 176280004322 putative DNA binding site [nucleotide binding]; other site 176280004323 putative metal binding site [ion binding]; other site 176280004324 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 176280004325 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 176280004326 active site 176280004327 DNA binding site [nucleotide binding] 176280004328 catalytic site [active] 176280004329 HAMP domain; Region: HAMP; pfam00672 176280004330 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 176280004331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176280004332 dimer interface [polypeptide binding]; other site 176280004333 phosphorylation site [posttranslational modification] 176280004334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280004335 ATP binding site [chemical binding]; other site 176280004336 Mg2+ binding site [ion binding]; other site 176280004337 G-X-G motif; other site 176280004338 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176280004339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280004340 active site 176280004341 phosphorylation site [posttranslational modification] 176280004342 intermolecular recognition site; other site 176280004343 dimerization interface [polypeptide binding]; other site 176280004344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176280004345 DNA binding site [nucleotide binding] 176280004346 isocitrate dehydrogenase; Reviewed; Region: PRK07006 176280004347 isocitrate dehydrogenase; Validated; Region: PRK07362 176280004348 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 176280004349 dimer interface [polypeptide binding]; other site 176280004350 Citrate synthase; Region: Citrate_synt; pfam00285 176280004351 active site 176280004352 citrylCoA binding site [chemical binding]; other site 176280004353 oxalacetate/citrate binding site [chemical binding]; other site 176280004354 coenzyme A binding site [chemical binding]; other site 176280004355 catalytic triad [active] 176280004356 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 176280004357 pyruvate kinase; Provisional; Region: PRK06354 176280004358 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 176280004359 domain interfaces; other site 176280004360 active site 176280004361 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 176280004362 6-phosphofructokinase; Provisional; Region: PRK03202 176280004363 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 176280004364 dimerization interface [polypeptide binding]; other site 176280004365 allosteric effector site; other site 176280004366 active site 176280004367 ADP/pyrophosphate binding site [chemical binding]; other site 176280004368 fructose-1,6-bisphosphate binding site; other site 176280004369 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 176280004370 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 176280004371 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 176280004372 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 176280004373 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 176280004374 Malic enzyme, N-terminal domain; Region: malic; pfam00390 176280004375 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 176280004376 putative NAD(P) binding site [chemical binding]; other site 176280004377 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 176280004378 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 176280004379 active site 176280004380 PHP Thumb interface [polypeptide binding]; other site 176280004381 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 176280004382 generic binding surface I; other site 176280004383 generic binding surface II; other site 176280004384 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 176280004385 DHH family; Region: DHH; pfam01368 176280004386 DHHA1 domain; Region: DHHA1; pfam02272 176280004387 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 176280004388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 176280004389 DNA-binding site [nucleotide binding]; DNA binding site 176280004390 DRTGG domain; Region: DRTGG; pfam07085 176280004391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 176280004392 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 176280004393 active site 2 [active] 176280004394 active site 1 [active] 176280004395 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 176280004396 Ligand Binding Site [chemical binding]; other site 176280004397 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 176280004398 metal-dependent hydrolase; Provisional; Region: PRK00685 176280004399 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 176280004400 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 176280004401 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 176280004402 active site 176280004403 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 176280004404 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 176280004405 hexamer interface [polypeptide binding]; other site 176280004406 ligand binding site [chemical binding]; other site 176280004407 putative active site [active] 176280004408 NAD(P) binding site [chemical binding]; other site 176280004409 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 176280004410 Ligand Binding Site [chemical binding]; other site 176280004411 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 176280004412 propionate/acetate kinase; Provisional; Region: PRK12379 176280004413 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 176280004414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280004415 S-adenosylmethionine binding site [chemical binding]; other site 176280004416 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 176280004417 dimer interface [polypeptide binding]; other site 176280004418 catalytic triad [active] 176280004419 peroxidatic and resolving cysteines [active] 176280004420 hypothetical protein; Provisional; Region: PRK10621 176280004421 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 176280004422 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 176280004423 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 176280004424 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 176280004425 Ligand Binding Site [chemical binding]; other site 176280004426 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 176280004427 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 176280004428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176280004429 catalytic residue [active] 176280004430 septation ring formation regulator EzrA; Provisional; Region: PRK04778 176280004431 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 176280004432 GAF domain; Region: GAF_2; pfam13185 176280004433 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 176280004434 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 176280004435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176280004436 RNA binding surface [nucleotide binding]; other site 176280004437 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 176280004438 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 176280004439 active site 176280004440 catalytic site [active] 176280004441 OsmC-like protein; Region: OsmC; cl00767 176280004442 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 176280004443 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176280004444 catalytic residue [active] 176280004445 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 176280004446 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 176280004447 ligand binding site [chemical binding]; other site 176280004448 NAD binding site [chemical binding]; other site 176280004449 dimerization interface [polypeptide binding]; other site 176280004450 catalytic site [active] 176280004451 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 176280004452 putative L-serine binding site [chemical binding]; other site 176280004453 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 176280004454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280004455 motif II; other site 176280004456 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 176280004457 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176280004458 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176280004459 active site turn [active] 176280004460 phosphorylation site [posttranslational modification] 176280004461 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 176280004462 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 176280004463 putative acyl-acceptor binding pocket; other site 176280004464 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 176280004465 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 176280004466 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 176280004467 protein binding site [polypeptide binding]; other site 176280004468 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 176280004469 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 176280004470 active site 176280004471 HIGH motif; other site 176280004472 dimer interface [polypeptide binding]; other site 176280004473 KMSKS motif; other site 176280004474 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176280004475 RNA binding surface [nucleotide binding]; other site 176280004476 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 176280004477 Transglycosylase; Region: Transgly; pfam00912 176280004478 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 176280004479 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 176280004480 Potassium binding sites [ion binding]; other site 176280004481 Cesium cation binding sites [ion binding]; other site 176280004482 catabolite control protein A; Region: ccpA; TIGR01481 176280004483 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 176280004484 DNA binding site [nucleotide binding] 176280004485 domain linker motif; other site 176280004486 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 176280004487 dimerization interface [polypeptide binding]; other site 176280004488 effector binding site; other site 176280004489 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 176280004490 Chorismate mutase type II; Region: CM_2; cl00693 176280004491 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 176280004492 YtxH-like protein; Region: YtxH; pfam12732 176280004493 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 176280004494 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 176280004495 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 176280004496 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176280004497 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176280004498 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 176280004499 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 176280004500 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 176280004501 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 176280004502 putative tRNA-binding site [nucleotide binding]; other site 176280004503 hypothetical protein; Provisional; Region: PRK13668 176280004504 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176280004505 catalytic residues [active] 176280004506 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 176280004507 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 176280004508 oligomer interface [polypeptide binding]; other site 176280004509 active site 176280004510 metal binding site [ion binding]; metal-binding site 176280004511 Predicted small secreted protein [Function unknown]; Region: COG5584 176280004512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280004513 S-adenosylmethionine binding site [chemical binding]; other site 176280004514 Phosphotransferase enzyme family; Region: APH; pfam01636 176280004515 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 176280004516 active site 176280004517 substrate binding site [chemical binding]; other site 176280004518 ATP binding site [chemical binding]; other site 176280004519 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 176280004520 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 176280004521 homodimer interface [polypeptide binding]; other site 176280004522 substrate-cofactor binding pocket; other site 176280004523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280004524 catalytic residue [active] 176280004525 dipeptidase PepV; Reviewed; Region: PRK07318 176280004526 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 176280004527 active site 176280004528 metal binding site [ion binding]; metal-binding site 176280004529 YtxH-like protein; Region: YtxH; pfam12732 176280004530 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 176280004531 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176280004532 RNA binding surface [nucleotide binding]; other site 176280004533 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 176280004534 active site 176280004535 uracil binding [chemical binding]; other site 176280004536 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 176280004537 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 176280004538 HI0933-like protein; Region: HI0933_like; pfam03486 176280004539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176280004540 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176280004541 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 176280004542 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004543 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004544 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004545 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004546 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004547 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004548 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004549 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004550 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004551 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004552 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004553 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004554 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004555 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004556 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004557 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004558 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004559 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004560 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004561 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004562 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004563 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004564 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004565 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004566 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004567 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004568 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004569 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004570 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004571 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004572 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004573 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176280004574 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176280004575 active site residue [active] 176280004576 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 176280004577 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 176280004578 HIGH motif; other site 176280004579 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 176280004580 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 176280004581 active site 176280004582 KMSKS motif; other site 176280004583 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 176280004584 tRNA binding surface [nucleotide binding]; other site 176280004585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280004586 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280004587 putative substrate translocation pore; other site 176280004588 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 176280004589 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 176280004590 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176280004591 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 176280004592 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 176280004593 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 176280004594 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 176280004595 homopentamer interface [polypeptide binding]; other site 176280004596 active site 176280004597 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 176280004598 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 176280004599 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 176280004600 dimerization interface [polypeptide binding]; other site 176280004601 active site 176280004602 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 176280004603 Lumazine binding domain; Region: Lum_binding; pfam00677 176280004604 Lumazine binding domain; Region: Lum_binding; pfam00677 176280004605 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 176280004606 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 176280004607 catalytic motif [active] 176280004608 Zn binding site [ion binding]; other site 176280004609 RibD C-terminal domain; Region: RibD_C; pfam01872 176280004610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 176280004611 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 176280004612 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 176280004613 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 176280004614 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 176280004615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 176280004616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 176280004617 DNA binding residues [nucleotide binding] 176280004618 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 176280004619 active site 176280004620 intersubunit interactions; other site 176280004621 catalytic residue [active] 176280004622 camphor resistance protein CrcB; Provisional; Region: PRK14201 176280004623 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 176280004624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280004625 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280004626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280004627 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280004628 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 176280004629 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 176280004630 active site 176280004631 catalytic tetrad [active] 176280004632 S-adenosylmethionine synthetase; Validated; Region: PRK05250 176280004633 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 176280004634 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 176280004635 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 176280004636 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 176280004637 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 176280004638 active site 176280004639 substrate-binding site [chemical binding]; other site 176280004640 metal-binding site [ion binding] 176280004641 ATP binding site [chemical binding]; other site 176280004642 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 176280004643 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 176280004644 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 176280004645 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 176280004646 nudix motif; other site 176280004647 Haemolytic domain; Region: Haemolytic; pfam01809 176280004648 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 176280004649 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 176280004650 metal binding site [ion binding]; metal-binding site 176280004651 substrate binding pocket [chemical binding]; other site 176280004652 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 176280004653 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 176280004654 acyl-activating enzyme (AAE) consensus motif; other site 176280004655 putative AMP binding site [chemical binding]; other site 176280004656 putative active site [active] 176280004657 putative CoA binding site [chemical binding]; other site 176280004658 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 176280004659 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 176280004660 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 176280004661 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 176280004662 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 176280004663 Int/Topo IB signature motif; other site 176280004664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280004665 AAA domain; Region: AAA_23; pfam13476 176280004666 Walker A/P-loop; other site 176280004667 ATP binding site [chemical binding]; other site 176280004668 AAA domain; Region: AAA_21; pfam13304 176280004669 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 176280004670 CHC2 zinc finger; Region: zf-CHC2; cl17510 176280004671 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 176280004672 Toprim-like; Region: Toprim_2; pfam13155 176280004673 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 176280004674 active site 176280004675 catalytic site [active] 176280004676 CAAX protease self-immunity; Region: Abi; pfam02517 176280004677 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 176280004678 DNA topoisomerase III; Provisional; Region: PRK07726 176280004679 active site 176280004680 putative interdomain interaction site [polypeptide binding]; other site 176280004681 putative metal-binding site [ion binding]; other site 176280004682 putative nucleotide binding site [chemical binding]; other site 176280004683 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 176280004684 domain I; other site 176280004685 DNA binding groove [nucleotide binding] 176280004686 phosphate binding site [ion binding]; other site 176280004687 domain II; other site 176280004688 domain III; other site 176280004689 nucleotide binding site [chemical binding]; other site 176280004690 catalytic site [active] 176280004691 domain IV; other site 176280004692 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 176280004693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 176280004694 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 176280004695 CHAP domain; Region: CHAP; pfam05257 176280004696 Surface antigen [General function prediction only]; Region: COG3942 176280004697 AAA-like domain; Region: AAA_10; pfam12846 176280004698 TrbC/VIRB2 family; Region: TrbC; pfam04956 176280004699 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 176280004700 Walker A motif; other site 176280004701 ATP binding site [chemical binding]; other site 176280004702 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 176280004703 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 176280004704 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 176280004705 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 176280004706 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 176280004707 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 176280004708 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 176280004709 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 176280004710 Domain of unknown function (DUF771); Region: DUF771; pfam05595 176280004711 Protein of unknown function (DUF935); Region: DUF935; pfam06074 176280004712 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 176280004713 Int/Topo IB signature motif; other site 176280004714 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 176280004715 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 176280004716 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 176280004717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 176280004718 ferrochelatase; Provisional; Region: PRK12435 176280004719 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 176280004720 C-terminal domain interface [polypeptide binding]; other site 176280004721 active site 176280004722 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 176280004723 active site 176280004724 N-terminal domain interface [polypeptide binding]; other site 176280004725 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 176280004726 substrate binding site [chemical binding]; other site 176280004727 active site 176280004728 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 176280004729 Cadmium resistance transporter; Region: Cad; pfam03596 176280004730 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 176280004731 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 176280004732 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176280004733 Walker A/P-loop; other site 176280004734 ATP binding site [chemical binding]; other site 176280004735 Q-loop/lid; other site 176280004736 ABC transporter signature motif; other site 176280004737 Walker B; other site 176280004738 D-loop; other site 176280004739 H-loop/switch region; other site 176280004740 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 176280004741 HIT family signature motif; other site 176280004742 catalytic residue [active] 176280004743 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 176280004744 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 176280004745 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 176280004746 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 176280004747 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 176280004748 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 176280004749 generic binding surface II; other site 176280004750 generic binding surface I; other site 176280004751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176280004752 Zn2+ binding site [ion binding]; other site 176280004753 Mg2+ binding site [ion binding]; other site 176280004754 Uncharacterized conserved protein [Function unknown]; Region: COG4717 176280004755 P-loop containing region of AAA domain; Region: AAA_29; cl17516 176280004756 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 176280004757 Peptidase family M48; Region: Peptidase_M48; cl12018 176280004758 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 176280004759 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 176280004760 active site 176280004761 metal binding site [ion binding]; metal-binding site 176280004762 DNA binding site [nucleotide binding] 176280004763 hypothetical protein; Provisional; Region: PRK13676 176280004764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 176280004765 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 176280004766 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176280004767 non-specific DNA binding site [nucleotide binding]; other site 176280004768 salt bridge; other site 176280004769 sequence-specific DNA binding site [nucleotide binding]; other site 176280004770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 176280004771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280004772 active site 176280004773 phosphorylation site [posttranslational modification] 176280004774 intermolecular recognition site; other site 176280004775 dimerization interface [polypeptide binding]; other site 176280004776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 176280004777 DNA binding residues [nucleotide binding] 176280004778 dimerization interface [polypeptide binding]; other site 176280004779 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 176280004780 GAF domain; Region: GAF_3; pfam13492 176280004781 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 176280004782 Histidine kinase; Region: HisKA_3; pfam07730 176280004783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280004784 ATP binding site [chemical binding]; other site 176280004785 Mg2+ binding site [ion binding]; other site 176280004786 G-X-G motif; other site 176280004787 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 176280004788 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 176280004789 active site 176280004790 fumarate hydratase; Reviewed; Region: fumC; PRK00485 176280004791 Class II fumarases; Region: Fumarase_classII; cd01362 176280004792 active site 176280004793 tetramer interface [polypeptide binding]; other site 176280004794 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 176280004795 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 176280004796 epoxyqueuosine reductase; Region: TIGR00276 176280004797 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 176280004798 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 176280004799 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 176280004800 Walker A/P-loop; other site 176280004801 ATP binding site [chemical binding]; other site 176280004802 Q-loop/lid; other site 176280004803 ABC transporter signature motif; other site 176280004804 Walker B; other site 176280004805 D-loop; other site 176280004806 H-loop/switch region; other site 176280004807 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 176280004808 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 176280004809 substrate binding pocket [chemical binding]; other site 176280004810 membrane-bound complex binding site; other site 176280004811 hinge residues; other site 176280004812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280004813 dimer interface [polypeptide binding]; other site 176280004814 conserved gate region; other site 176280004815 ABC-ATPase subunit interface; other site 176280004816 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 176280004817 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 176280004818 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 176280004819 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 176280004820 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 176280004821 metal binding site 2 [ion binding]; metal-binding site 176280004822 putative DNA binding helix; other site 176280004823 metal binding site 1 [ion binding]; metal-binding site 176280004824 dimer interface [polypeptide binding]; other site 176280004825 structural Zn2+ binding site [ion binding]; other site 176280004826 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 176280004827 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 176280004828 putative ligand binding site [chemical binding]; other site 176280004829 NAD binding site [chemical binding]; other site 176280004830 catalytic site [active] 176280004831 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 176280004832 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 176280004833 catalytic triad [active] 176280004834 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 176280004835 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176280004836 inhibitor-cofactor binding pocket; inhibition site 176280004837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280004838 catalytic residue [active] 176280004839 Predicted membrane protein [Function unknown]; Region: COG4129 176280004840 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 176280004841 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 176280004842 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 176280004843 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 176280004844 Walker A/P-loop; other site 176280004845 ATP binding site [chemical binding]; other site 176280004846 Q-loop/lid; other site 176280004847 ABC transporter signature motif; other site 176280004848 Walker B; other site 176280004849 D-loop; other site 176280004850 H-loop/switch region; other site 176280004851 hypothetical protein; Provisional; Region: PRK13662 176280004852 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 176280004853 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 176280004854 minor groove reading motif; other site 176280004855 helix-hairpin-helix signature motif; other site 176280004856 substrate binding pocket [chemical binding]; other site 176280004857 active site 176280004858 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 176280004859 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 176280004860 DNA binding and oxoG recognition site [nucleotide binding] 176280004861 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 176280004862 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 176280004863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280004864 Walker A/P-loop; other site 176280004865 ATP binding site [chemical binding]; other site 176280004866 Q-loop/lid; other site 176280004867 ABC transporter signature motif; other site 176280004868 Walker B; other site 176280004869 D-loop; other site 176280004870 H-loop/switch region; other site 176280004871 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 176280004872 recombination regulator RecX; Provisional; Region: recX; PRK14135 176280004873 glycosyltransferase; Provisional; Region: PRK13481 176280004874 Transglycosylase; Region: Transgly; pfam00912 176280004875 intracellular protease, PfpI family; Region: PfpI; TIGR01382 176280004876 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 176280004877 proposed catalytic triad [active] 176280004878 conserved cys residue [active] 176280004879 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 176280004880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280004881 FeS/SAM binding site; other site 176280004882 YfkB-like domain; Region: YfkB; pfam08756 176280004883 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 176280004884 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 176280004885 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 176280004886 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 176280004887 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 176280004888 Low molecular weight phosphatase family; Region: LMWPc; cd00115 176280004889 active site 176280004890 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 176280004891 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 176280004892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280004893 active site 176280004894 phosphorylation site [posttranslational modification] 176280004895 intermolecular recognition site; other site 176280004896 dimerization interface [polypeptide binding]; other site 176280004897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 176280004898 DNA binding residues [nucleotide binding] 176280004899 dimerization interface [polypeptide binding]; other site 176280004900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 176280004901 Histidine kinase; Region: HisKA_3; pfam07730 176280004902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280004903 ATP binding site [chemical binding]; other site 176280004904 Mg2+ binding site [ion binding]; other site 176280004905 G-X-G motif; other site 176280004906 Predicted membrane protein [Function unknown]; Region: COG4758 176280004907 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 176280004908 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 176280004909 active site 176280004910 Predicted membrane protein [Function unknown]; Region: COG4129 176280004911 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 176280004912 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 176280004913 catalytic triad [active] 176280004914 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 176280004915 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176280004916 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 176280004917 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 176280004918 Ferritin-like domain; Region: Ferritin; pfam00210 176280004919 ferroxidase diiron center [ion binding]; other site 176280004920 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 176280004921 active site 176280004922 catalytic site [active] 176280004923 substrate binding site [chemical binding]; other site 176280004924 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 176280004925 active site 176280004926 DNA polymerase IV; Validated; Region: PRK02406 176280004927 DNA binding site [nucleotide binding] 176280004928 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 176280004929 TRAM domain; Region: TRAM; cl01282 176280004930 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 176280004931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280004932 S-adenosylmethionine binding site [chemical binding]; other site 176280004933 putative lipid kinase; Reviewed; Region: PRK13337 176280004934 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 176280004935 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 176280004936 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 176280004937 GatB domain; Region: GatB_Yqey; pfam02637 176280004938 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 176280004939 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 176280004940 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 176280004941 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 176280004942 Na binding site [ion binding]; other site 176280004943 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 176280004944 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 176280004945 putative dimer interface [polypeptide binding]; other site 176280004946 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 176280004947 putative dimer interface [polypeptide binding]; other site 176280004948 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 176280004949 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 176280004950 nucleotide binding pocket [chemical binding]; other site 176280004951 K-X-D-G motif; other site 176280004952 catalytic site [active] 176280004953 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 176280004954 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 176280004955 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 176280004956 Dimer interface [polypeptide binding]; other site 176280004957 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 176280004958 Part of AAA domain; Region: AAA_19; pfam13245 176280004959 Family description; Region: UvrD_C_2; pfam13538 176280004960 PcrB family; Region: PcrB; pfam01884 176280004961 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 176280004962 substrate binding site [chemical binding]; other site 176280004963 putative active site [active] 176280004964 dimer interface [polypeptide binding]; other site 176280004965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 176280004966 adenylosuccinate lyase; Provisional; Region: PRK07492 176280004967 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 176280004968 tetramer interface [polypeptide binding]; other site 176280004969 active site 176280004970 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 176280004971 NETI protein; Region: NETI; pfam14044 176280004972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 176280004973 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 176280004974 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 176280004975 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 176280004976 homodimer interface [polypeptide binding]; other site 176280004977 NAD binding pocket [chemical binding]; other site 176280004978 ATP binding pocket [chemical binding]; other site 176280004979 Mg binding site [ion binding]; other site 176280004980 active-site loop [active] 176280004981 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 176280004982 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 176280004983 active site 176280004984 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 176280004985 active site 176280004986 dimer interface [polypeptide binding]; other site 176280004987 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 176280004988 Prephenate dehydratase; Region: PDT; pfam00800 176280004989 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 176280004990 putative L-Phe binding site [chemical binding]; other site 176280004991 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 176280004992 Isochorismatase family; Region: Isochorismatase; pfam00857 176280004993 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 176280004994 catalytic triad [active] 176280004995 conserved cis-peptide bond; other site 176280004996 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 176280004997 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 176280004998 DHHA2 domain; Region: DHHA2; pfam02833 176280004999 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 176280005000 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 176280005001 NAD(P) binding site [chemical binding]; other site 176280005002 catalytic residues [active] 176280005003 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 176280005004 Predicted transcriptional regulator [Transcription]; Region: COG3682 176280005005 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 176280005006 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 176280005007 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 176280005008 YolD-like protein; Region: YolD; pfam08863 176280005009 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 176280005010 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 176280005011 Int/Topo IB signature motif; other site 176280005012 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 176280005013 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 176280005014 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 176280005015 Int/Topo IB signature motif; other site 176280005016 YolD-like protein; Region: YolD; pfam08863 176280005017 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 176280005018 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 176280005019 active site 176280005020 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 176280005021 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 176280005022 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 176280005023 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176280005024 Walker A/P-loop; other site 176280005025 ATP binding site [chemical binding]; other site 176280005026 Q-loop/lid; other site 176280005027 ABC transporter signature motif; other site 176280005028 Walker B; other site 176280005029 D-loop; other site 176280005030 H-loop/switch region; other site 176280005031 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 176280005032 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 176280005033 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176280005034 Walker A/P-loop; other site 176280005035 ATP binding site [chemical binding]; other site 176280005036 Q-loop/lid; other site 176280005037 ABC transporter signature motif; other site 176280005038 Walker B; other site 176280005039 D-loop; other site 176280005040 H-loop/switch region; other site 176280005041 Predicted transcriptional regulators [Transcription]; Region: COG1725 176280005042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 176280005043 DNA-binding site [nucleotide binding]; DNA binding site 176280005044 hypothetical protein; Provisional; Region: PRK08637 176280005045 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 176280005046 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 176280005047 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 176280005048 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 176280005049 ring oligomerisation interface [polypeptide binding]; other site 176280005050 ATP/Mg binding site [chemical binding]; other site 176280005051 stacking interactions; other site 176280005052 hinge regions; other site 176280005053 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 176280005054 oligomerisation interface [polypeptide binding]; other site 176280005055 mobile loop; other site 176280005056 roof hairpin; other site 176280005057 CAAX protease self-immunity; Region: Abi; pfam02517 176280005058 Predicted amidohydrolase [General function prediction only]; Region: COG0388 176280005059 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 176280005060 putative active site [active] 176280005061 catalytic triad [active] 176280005062 putative dimer interface [polypeptide binding]; other site 176280005063 delta-hemolysin; Provisional; Region: PRK14752 176280005064 Accessory gene regulator B; Region: AgrB; smart00793 176280005065 Staphylococcal AgrD protein; Region: AgrD; pfam05931 176280005066 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 176280005067 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 176280005068 ATP binding site [chemical binding]; other site 176280005069 Mg2+ binding site [ion binding]; other site 176280005070 G-X-G motif; other site 176280005071 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 176280005072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280005073 active site 176280005074 phosphorylation site [posttranslational modification] 176280005075 intermolecular recognition site; other site 176280005076 dimerization interface [polypeptide binding]; other site 176280005077 LytTr DNA-binding domain; Region: LytTR; pfam04397 176280005078 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 176280005079 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 176280005080 putative substrate binding site [chemical binding]; other site 176280005081 putative ATP binding site [chemical binding]; other site 176280005082 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 176280005083 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 176280005084 substrate binding [chemical binding]; other site 176280005085 active site 176280005086 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 176280005087 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 176280005088 Transcriptional regulators [Transcription]; Region: PurR; COG1609 176280005089 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 176280005090 DNA binding site [nucleotide binding] 176280005091 domain linker motif; other site 176280005092 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 176280005093 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 176280005094 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 176280005095 CPxP motif; other site 176280005096 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 176280005097 Sulphur transport; Region: Sulf_transp; pfam04143 176280005098 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 176280005099 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 176280005100 CoA binding domain; Region: CoA_binding; pfam02629 176280005101 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 176280005102 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176280005103 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176280005104 ABC transporter; Region: ABC_tran_2; pfam12848 176280005105 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176280005106 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 176280005107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280005108 Walker A/P-loop; other site 176280005109 ATP binding site [chemical binding]; other site 176280005110 Q-loop/lid; other site 176280005111 ABC transporter signature motif; other site 176280005112 Walker B; other site 176280005113 D-loop; other site 176280005114 H-loop/switch region; other site 176280005115 UGMP family protein; Validated; Region: PRK09604 176280005116 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 176280005117 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 176280005118 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 176280005119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280005120 Coenzyme A binding pocket [chemical binding]; other site 176280005121 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 176280005122 Glycoprotease family; Region: Peptidase_M22; pfam00814 176280005123 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 176280005124 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 176280005125 6-phosphogluconate dehydratase; Region: edd; TIGR01196 176280005126 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 176280005127 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 176280005128 PYR/PP interface [polypeptide binding]; other site 176280005129 dimer interface [polypeptide binding]; other site 176280005130 TPP binding site [chemical binding]; other site 176280005131 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 176280005132 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 176280005133 TPP-binding site [chemical binding]; other site 176280005134 dimer interface [polypeptide binding]; other site 176280005135 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 176280005136 ketol-acid reductoisomerase; Provisional; Region: PRK05479 176280005137 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 176280005138 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 176280005139 2-isopropylmalate synthase; Validated; Region: PRK00915 176280005140 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 176280005141 active site 176280005142 catalytic residues [active] 176280005143 metal binding site [ion binding]; metal-binding site 176280005144 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 176280005145 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 176280005146 tartrate dehydrogenase; Region: TTC; TIGR02089 176280005147 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 176280005148 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 176280005149 substrate binding site [chemical binding]; other site 176280005150 ligand binding site [chemical binding]; other site 176280005151 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 176280005152 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 176280005153 substrate binding site [chemical binding]; other site 176280005154 threonine dehydratase; Validated; Region: PRK08639 176280005155 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 176280005156 tetramer interface [polypeptide binding]; other site 176280005157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280005158 catalytic residue [active] 176280005159 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 176280005160 putative Ile/Val binding site [chemical binding]; other site 176280005161 hypothetical protein; Provisional; Region: PRK04351 176280005162 SprT homologues; Region: SprT; cl01182 176280005163 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 176280005164 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 176280005165 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 176280005166 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 176280005167 RNA binding site [nucleotide binding]; other site 176280005168 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 176280005169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 176280005170 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 176280005171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 176280005172 DNA binding residues [nucleotide binding] 176280005173 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 176280005174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280005175 ATP binding site [chemical binding]; other site 176280005176 Mg2+ binding site [ion binding]; other site 176280005177 G-X-G motif; other site 176280005178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 176280005179 anti sigma factor interaction site; other site 176280005180 regulatory phosphorylation site [posttranslational modification]; other site 176280005181 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 176280005182 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 176280005183 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 176280005184 PemK-like protein; Region: PemK; pfam02452 176280005185 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 176280005186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 176280005187 active site 176280005188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176280005189 dimer interface [polypeptide binding]; other site 176280005190 substrate binding site [chemical binding]; other site 176280005191 catalytic residues [active] 176280005192 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 176280005193 Uncharacterized conserved protein [Function unknown]; Region: COG3402 176280005194 Predicted membrane protein [Function unknown]; Region: COG3428 176280005195 Bacterial PH domain; Region: DUF304; pfam03703 176280005196 Bacterial PH domain; Region: DUF304; pfam03703 176280005197 Bacterial PH domain; Region: DUF304; cl01348 176280005198 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 176280005199 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 176280005200 ATP binding site [chemical binding]; other site 176280005201 Mg++ binding site [ion binding]; other site 176280005202 motif III; other site 176280005203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280005204 nucleotide binding region [chemical binding]; other site 176280005205 ATP-binding site [chemical binding]; other site 176280005206 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 176280005207 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 176280005208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176280005209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176280005210 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 176280005211 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 176280005212 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 176280005213 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 176280005214 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 176280005215 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 176280005216 putative homodimer interface [polypeptide binding]; other site 176280005217 putative homotetramer interface [polypeptide binding]; other site 176280005218 allosteric switch controlling residues; other site 176280005219 putative metal binding site [ion binding]; other site 176280005220 putative homodimer-homodimer interface [polypeptide binding]; other site 176280005221 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 176280005222 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 176280005223 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 176280005224 putative active site [active] 176280005225 catalytic site [active] 176280005226 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 176280005227 putative active site [active] 176280005228 catalytic site [active] 176280005229 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 176280005230 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176280005231 Zn2+ binding site [ion binding]; other site 176280005232 Mg2+ binding site [ion binding]; other site 176280005233 OxaA-like protein precursor; Provisional; Region: PRK02463 176280005234 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 176280005235 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 176280005236 thiamine phosphate binding site [chemical binding]; other site 176280005237 active site 176280005238 pyrophosphate binding site [ion binding]; other site 176280005239 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 176280005240 substrate binding site [chemical binding]; other site 176280005241 multimerization interface [polypeptide binding]; other site 176280005242 ATP binding site [chemical binding]; other site 176280005243 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 176280005244 dimer interface [polypeptide binding]; other site 176280005245 substrate binding site [chemical binding]; other site 176280005246 ATP binding site [chemical binding]; other site 176280005247 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 176280005248 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 176280005249 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 176280005250 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 176280005251 dimer interface [polypeptide binding]; other site 176280005252 ssDNA binding site [nucleotide binding]; other site 176280005253 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176280005254 YwpF-like protein; Region: YwpF; pfam14183 176280005255 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 176280005256 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 176280005257 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 176280005258 hinge; other site 176280005259 active site 176280005260 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 176280005261 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 176280005262 gamma subunit interface [polypeptide binding]; other site 176280005263 epsilon subunit interface [polypeptide binding]; other site 176280005264 LBP interface [polypeptide binding]; other site 176280005265 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 176280005266 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 176280005267 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 176280005268 alpha subunit interaction interface [polypeptide binding]; other site 176280005269 Walker A motif; other site 176280005270 ATP binding site [chemical binding]; other site 176280005271 Walker B motif; other site 176280005272 inhibitor binding site; inhibition site 176280005273 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 176280005274 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 176280005275 core domain interface [polypeptide binding]; other site 176280005276 delta subunit interface [polypeptide binding]; other site 176280005277 epsilon subunit interface [polypeptide binding]; other site 176280005278 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 176280005279 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 176280005280 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 176280005281 beta subunit interaction interface [polypeptide binding]; other site 176280005282 Walker A motif; other site 176280005283 ATP binding site [chemical binding]; other site 176280005284 Walker B motif; other site 176280005285 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 176280005286 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 176280005287 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 176280005288 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 176280005289 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 176280005290 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 176280005291 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 176280005292 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 176280005293 ATP synthase I chain; Region: ATP_synt_I; pfam03899 176280005294 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 176280005295 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 176280005296 active site 176280005297 homodimer interface [polypeptide binding]; other site 176280005298 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176280005299 active site 176280005300 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 176280005301 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 176280005302 dimer interface [polypeptide binding]; other site 176280005303 active site 176280005304 glycine-pyridoxal phosphate binding site [chemical binding]; other site 176280005305 folate binding site [chemical binding]; other site 176280005306 hypothetical protein; Provisional; Region: PRK13690 176280005307 Low molecular weight phosphatase family; Region: LMWPc; cd00115 176280005308 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 176280005309 active site 176280005310 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 176280005311 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 176280005312 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 176280005313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280005314 S-adenosylmethionine binding site [chemical binding]; other site 176280005315 peptide chain release factor 1; Validated; Region: prfA; PRK00591 176280005316 This domain is found in peptide chain release factors; Region: PCRF; smart00937 176280005317 RF-1 domain; Region: RF-1; pfam00472 176280005318 thymidine kinase; Provisional; Region: PRK04296 176280005319 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 176280005320 transcription termination factor Rho; Provisional; Region: rho; PRK09376 176280005321 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 176280005322 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 176280005323 RNA binding site [nucleotide binding]; other site 176280005324 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 176280005325 Walker A motif; other site 176280005326 ATP binding site [chemical binding]; other site 176280005327 Walker B motif; other site 176280005328 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 176280005329 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 176280005330 NAD binding site [chemical binding]; other site 176280005331 catalytic residues [active] 176280005332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280005333 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280005334 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 176280005335 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 176280005336 hinge; other site 176280005337 active site 176280005338 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 176280005339 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 176280005340 intersubunit interface [polypeptide binding]; other site 176280005341 active site 176280005342 zinc binding site [ion binding]; other site 176280005343 Na+ binding site [ion binding]; other site 176280005344 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 176280005345 CTP synthetase; Validated; Region: pyrG; PRK05380 176280005346 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 176280005347 Catalytic site [active] 176280005348 active site 176280005349 UTP binding site [chemical binding]; other site 176280005350 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 176280005351 active site 176280005352 putative oxyanion hole; other site 176280005353 catalytic triad [active] 176280005354 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 176280005355 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 176280005356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280005357 Coenzyme A binding pocket [chemical binding]; other site 176280005358 pantothenate kinase; Provisional; Region: PRK13317 176280005359 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 176280005360 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 176280005361 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 176280005362 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176280005363 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 176280005364 metal binding site [ion binding]; metal-binding site 176280005365 S-ribosylhomocysteinase; Provisional; Region: PRK02260 176280005366 Predicted membrane protein [Function unknown]; Region: COG4270 176280005367 phosphopentomutase; Provisional; Region: PRK05362 176280005368 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 176280005369 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 176280005370 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 176280005371 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 176280005372 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 176280005373 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 176280005374 intersubunit interface [polypeptide binding]; other site 176280005375 active site 176280005376 catalytic residue [active] 176280005377 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 176280005378 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 176280005379 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 176280005380 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 176280005381 dimerization interface [polypeptide binding]; other site 176280005382 DPS ferroxidase diiron center [ion binding]; other site 176280005383 ion pore; other site 176280005384 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 176280005385 EVE domain; Region: EVE; cl00728 176280005386 EVE domain; Region: EVE; cl00728 176280005387 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 176280005388 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 176280005389 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 176280005390 NADH(P)-binding; Region: NAD_binding_10; pfam13460 176280005391 NAD(P) binding site [chemical binding]; other site 176280005392 putative active site [active] 176280005393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176280005394 dimerization interface [polypeptide binding]; other site 176280005395 putative DNA binding site [nucleotide binding]; other site 176280005396 putative Zn2+ binding site [ion binding]; other site 176280005397 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 176280005398 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 176280005399 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 176280005400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 176280005401 active site 176280005402 metal binding site [ion binding]; metal-binding site 176280005403 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 176280005404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280005405 active site 176280005406 motif I; other site 176280005407 motif II; other site 176280005408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280005409 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 176280005410 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 176280005411 glutaminase active site [active] 176280005412 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 176280005413 dimer interface [polypeptide binding]; other site 176280005414 active site 176280005415 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 176280005416 dimer interface [polypeptide binding]; other site 176280005417 active site 176280005418 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 176280005419 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 176280005420 active site 176280005421 substrate binding site [chemical binding]; other site 176280005422 metal binding site [ion binding]; metal-binding site 176280005423 YbbR-like protein; Region: YbbR; pfam07949 176280005424 YbbR-like protein; Region: YbbR; pfam07949 176280005425 TIGR00159 family protein; Region: TIGR00159 176280005426 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 176280005427 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 176280005428 Walker A motif; other site 176280005429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280005430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280005431 putative substrate translocation pore; other site 176280005432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280005433 putative transporter; Provisional; Region: PRK10504 176280005434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280005435 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 176280005436 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 176280005437 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 176280005438 substrate binding site; other site 176280005439 dimerization interface; other site 176280005440 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 176280005441 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13315 176280005442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 176280005443 Nucleoside recognition; Region: Gate; pfam07670 176280005444 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 176280005445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176280005446 ABC-ATPase subunit interface; other site 176280005447 dimer interface [polypeptide binding]; other site 176280005448 putative PBP binding regions; other site 176280005449 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 176280005450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176280005451 ABC-ATPase subunit interface; other site 176280005452 dimer interface [polypeptide binding]; other site 176280005453 putative PBP binding regions; other site 176280005454 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 176280005455 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 176280005456 siderophore binding site; other site 176280005457 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 176280005458 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 176280005459 dimer interface [polypeptide binding]; other site 176280005460 active site 176280005461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176280005462 substrate binding site [chemical binding]; other site 176280005463 catalytic residue [active] 176280005464 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 176280005465 IucA / IucC family; Region: IucA_IucC; pfam04183 176280005466 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 176280005467 H+ Antiporter protein; Region: 2A0121; TIGR00900 176280005468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280005469 putative substrate translocation pore; other site 176280005470 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 176280005471 IucA / IucC family; Region: IucA_IucC; pfam04183 176280005472 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 176280005473 Asp23 family; Region: Asp23; pfam03780 176280005474 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 176280005475 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 176280005476 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 176280005477 putative NAD(P) binding site [chemical binding]; other site 176280005478 dimer interface [polypeptide binding]; other site 176280005479 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 176280005480 Prostaglandin dehydrogenases; Region: PGDH; cd05288 176280005481 NAD(P) binding site [chemical binding]; other site 176280005482 substrate binding site [chemical binding]; other site 176280005483 dimer interface [polypeptide binding]; other site 176280005484 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 176280005485 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 176280005486 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 176280005487 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 176280005488 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 176280005489 beta-galactosidase; Region: BGL; TIGR03356 176280005490 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 176280005491 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 176280005492 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 176280005493 active site 176280005494 P-loop; other site 176280005495 phosphorylation site [posttranslational modification] 176280005496 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 176280005497 methionine cluster; other site 176280005498 active site 176280005499 phosphorylation site [posttranslational modification] 176280005500 metal binding site [ion binding]; metal-binding site 176280005501 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 176280005502 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 176280005503 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 176280005504 putative substrate binding site [chemical binding]; other site 176280005505 putative ATP binding site [chemical binding]; other site 176280005506 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 176280005507 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 176280005508 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 176280005509 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 176280005510 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 176280005511 NAD-dependent deacetylase; Provisional; Region: PRK00481 176280005512 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 176280005513 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 176280005514 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 176280005515 23S rRNA interface [nucleotide binding]; other site 176280005516 L3 interface [polypeptide binding]; other site 176280005517 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 176280005518 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 176280005519 dimerization interface 3.5A [polypeptide binding]; other site 176280005520 active site 176280005521 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 176280005522 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 176280005523 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 176280005524 Walker A/P-loop; other site 176280005525 ATP binding site [chemical binding]; other site 176280005526 Q-loop/lid; other site 176280005527 ABC transporter signature motif; other site 176280005528 Walker B; other site 176280005529 D-loop; other site 176280005530 H-loop/switch region; other site 176280005531 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 176280005532 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 176280005533 Walker A/P-loop; other site 176280005534 ATP binding site [chemical binding]; other site 176280005535 Q-loop/lid; other site 176280005536 ABC transporter signature motif; other site 176280005537 Walker B; other site 176280005538 D-loop; other site 176280005539 H-loop/switch region; other site 176280005540 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 176280005541 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 176280005542 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 176280005543 alphaNTD homodimer interface [polypeptide binding]; other site 176280005544 alphaNTD - beta interaction site [polypeptide binding]; other site 176280005545 alphaNTD - beta' interaction site [polypeptide binding]; other site 176280005546 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 176280005547 30S ribosomal protein S11; Validated; Region: PRK05309 176280005548 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 176280005549 30S ribosomal protein S13; Region: bact_S13; TIGR03631 176280005550 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 176280005551 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 176280005552 rRNA binding site [nucleotide binding]; other site 176280005553 predicted 30S ribosome binding site; other site 176280005554 adenylate kinase; Reviewed; Region: adk; PRK00279 176280005555 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 176280005556 AMP-binding site [chemical binding]; other site 176280005557 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 176280005558 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 176280005559 SecY translocase; Region: SecY; pfam00344 176280005560 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 176280005561 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 176280005562 23S rRNA binding site [nucleotide binding]; other site 176280005563 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 176280005564 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 176280005565 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 176280005566 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 176280005567 5S rRNA interface [nucleotide binding]; other site 176280005568 L27 interface [polypeptide binding]; other site 176280005569 23S rRNA interface [nucleotide binding]; other site 176280005570 L5 interface [polypeptide binding]; other site 176280005571 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 176280005572 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 176280005573 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 176280005574 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 176280005575 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 176280005576 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 176280005577 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 176280005578 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 176280005579 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 176280005580 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 176280005581 RNA binding site [nucleotide binding]; other site 176280005582 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 176280005583 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 176280005584 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 176280005585 23S rRNA interface [nucleotide binding]; other site 176280005586 putative translocon interaction site; other site 176280005587 signal recognition particle (SRP54) interaction site; other site 176280005588 L23 interface [polypeptide binding]; other site 176280005589 trigger factor interaction site; other site 176280005590 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 176280005591 23S rRNA interface [nucleotide binding]; other site 176280005592 5S rRNA interface [nucleotide binding]; other site 176280005593 putative antibiotic binding site [chemical binding]; other site 176280005594 L25 interface [polypeptide binding]; other site 176280005595 L27 interface [polypeptide binding]; other site 176280005596 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 176280005597 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 176280005598 G-X-X-G motif; other site 176280005599 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 176280005600 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 176280005601 putative translocon binding site; other site 176280005602 protein-rRNA interface [nucleotide binding]; other site 176280005603 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 176280005604 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 176280005605 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 176280005606 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 176280005607 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 176280005608 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 176280005609 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 176280005610 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 176280005611 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 176280005612 DNA topoisomerase III; Provisional; Region: PRK07726 176280005613 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 176280005614 active site 176280005615 putative interdomain interaction site [polypeptide binding]; other site 176280005616 putative metal-binding site [ion binding]; other site 176280005617 putative nucleotide binding site [chemical binding]; other site 176280005618 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 176280005619 domain I; other site 176280005620 DNA binding groove [nucleotide binding] 176280005621 phosphate binding site [ion binding]; other site 176280005622 domain II; other site 176280005623 domain III; other site 176280005624 nucleotide binding site [chemical binding]; other site 176280005625 catalytic site [active] 176280005626 domain IV; other site 176280005627 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 176280005628 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 176280005629 Sugar transport protein; Region: Sugar_transport; pfam06800 176280005630 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 176280005631 glucose-1-dehydrogenase; Provisional; Region: PRK08936 176280005632 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 176280005633 NAD binding site [chemical binding]; other site 176280005634 homodimer interface [polypeptide binding]; other site 176280005635 active site 176280005636 Predicted permeases [General function prediction only]; Region: COG0679 176280005637 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 176280005638 Protein export membrane protein; Region: SecD_SecF; cl14618 176280005639 Protein export membrane protein; Region: SecD_SecF; cl14618 176280005640 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 176280005641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 176280005642 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 176280005643 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 176280005644 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176280005645 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 176280005646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280005647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280005648 putative substrate translocation pore; other site 176280005649 Transposase domain (DUF772); Region: DUF772; pfam05598 176280005650 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176280005651 Transcriptional regulators [Transcription]; Region: MarR; COG1846 176280005652 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 176280005653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280005654 FeS/SAM binding site; other site 176280005655 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 176280005656 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 176280005657 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 176280005658 GTP binding site; other site 176280005659 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 176280005660 MoaE interaction surface [polypeptide binding]; other site 176280005661 MoeB interaction surface [polypeptide binding]; other site 176280005662 thiocarboxylated glycine; other site 176280005663 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 176280005664 MoaE homodimer interface [polypeptide binding]; other site 176280005665 MoaD interaction [polypeptide binding]; other site 176280005666 active site residues [active] 176280005667 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 176280005668 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 176280005669 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 176280005670 dimer interface [polypeptide binding]; other site 176280005671 putative functional site; other site 176280005672 putative MPT binding site; other site 176280005673 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 176280005674 trimer interface [polypeptide binding]; other site 176280005675 dimer interface [polypeptide binding]; other site 176280005676 putative active site [active] 176280005677 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 176280005678 MPT binding site; other site 176280005679 trimer interface [polypeptide binding]; other site 176280005680 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 176280005681 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 176280005682 ATP binding site [chemical binding]; other site 176280005683 substrate interface [chemical binding]; other site 176280005684 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 176280005685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280005686 Walker A/P-loop; other site 176280005687 ATP binding site [chemical binding]; other site 176280005688 Q-loop/lid; other site 176280005689 ABC transporter signature motif; other site 176280005690 Walker B; other site 176280005691 D-loop; other site 176280005692 H-loop/switch region; other site 176280005693 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 176280005694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280005695 dimer interface [polypeptide binding]; other site 176280005696 conserved gate region; other site 176280005697 putative PBP binding loops; other site 176280005698 ABC-ATPase subunit interface; other site 176280005699 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 176280005700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 176280005701 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 176280005702 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 176280005703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280005704 Coenzyme A binding pocket [chemical binding]; other site 176280005705 BioY family; Region: BioY; pfam02632 176280005706 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 176280005707 active site 176280005708 dimerization interface [polypeptide binding]; other site 176280005709 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 176280005710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 176280005711 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 176280005712 urea transporter, Yersinia type; Region: urea_trans_yut; TIGR03441 176280005713 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 176280005714 alpha-gamma subunit interface [polypeptide binding]; other site 176280005715 beta-gamma subunit interface [polypeptide binding]; other site 176280005716 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 176280005717 gamma-beta subunit interface [polypeptide binding]; other site 176280005718 alpha-beta subunit interface [polypeptide binding]; other site 176280005719 urease subunit alpha; Reviewed; Region: ureC; PRK13207 176280005720 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 176280005721 subunit interactions [polypeptide binding]; other site 176280005722 active site 176280005723 flap region; other site 176280005724 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 176280005725 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 176280005726 dimer interface [polypeptide binding]; other site 176280005727 catalytic residues [active] 176280005728 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 176280005729 UreF; Region: UreF; pfam01730 176280005730 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 176280005731 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 176280005732 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176280005733 MarR family; Region: MarR_2; cl17246 176280005734 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176280005735 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176280005736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 176280005737 Surface antigen [General function prediction only]; Region: COG3942 176280005738 CHAP domain; Region: CHAP; pfam05257 176280005739 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 176280005740 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 176280005741 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 176280005742 Tic20-like protein; Region: Tic20; pfam09685 176280005743 Surface antigen [General function prediction only]; Region: COG3942 176280005744 CHAP domain; Region: CHAP; pfam05257 176280005745 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 176280005746 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 176280005747 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 176280005748 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 176280005749 putative ligand binding site [chemical binding]; other site 176280005750 putative NAD binding site [chemical binding]; other site 176280005751 catalytic site [active] 176280005752 hypothetical protein; Provisional; Region: PRK06753 176280005753 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 176280005754 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 176280005755 Lysozyme subfamily 2; Region: LYZ2; smart00047 176280005756 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 176280005757 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 176280005758 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 176280005759 active site 176280005760 Predicted transcriptional regulator [Transcription]; Region: COG2378 176280005761 HTH domain; Region: HTH_11; pfam08279 176280005762 CAAX protease self-immunity; Region: Abi; pfam02517 176280005763 Uncharacterized conserved protein [Function unknown]; Region: COG3589 176280005764 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 176280005765 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 176280005766 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 176280005767 putative active site [active] 176280005768 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176280005769 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 176280005770 active site turn [active] 176280005771 phosphorylation site [posttranslational modification] 176280005772 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176280005773 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 176280005774 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 176280005775 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 176280005776 putative active site [active] 176280005777 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 176280005778 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 176280005779 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 176280005780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280005781 motif II; other site 176280005782 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 176280005783 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176280005784 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176280005785 active site turn [active] 176280005786 phosphorylation site [posttranslational modification] 176280005787 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 176280005788 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 176280005789 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 176280005790 putative active site [active] 176280005791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280005792 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280005793 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 176280005794 putative hydrophobic ligand binding site [chemical binding]; other site 176280005795 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 176280005796 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 176280005797 oxidoreductase; Provisional; Region: PRK07985 176280005798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176280005799 NAD(P) binding site [chemical binding]; other site 176280005800 active site 176280005801 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176280005802 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 176280005803 metal binding site [ion binding]; metal-binding site 176280005804 dimer interface [polypeptide binding]; other site 176280005805 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 176280005806 putative active site [active] 176280005807 putative metal binding site [ion binding]; other site 176280005808 CAAX protease self-immunity; Region: Abi; pfam02517 176280005809 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 176280005810 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176280005811 active site 176280005812 dimer interface [polypeptide binding]; other site 176280005813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 176280005814 MOSC domain; Region: MOSC; pfam03473 176280005815 3-alpha domain; Region: 3-alpha; pfam03475 176280005816 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 176280005817 active site 176280005818 catalytic residues [active] 176280005819 ribulokinase; Provisional; Region: PRK04123 176280005820 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 176280005821 N- and C-terminal domain interface [polypeptide binding]; other site 176280005822 active site 176280005823 MgATP binding site [chemical binding]; other site 176280005824 catalytic site [active] 176280005825 metal binding site [ion binding]; metal-binding site 176280005826 carbohydrate binding site [chemical binding]; other site 176280005827 homodimer interface [polypeptide binding]; other site 176280005828 Protein of unknown function (DUF805); Region: DUF805; pfam05656 176280005829 Protein of unknown function (DUF805); Region: DUF805; cl01224 176280005830 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 176280005831 active site 176280005832 DNA binding site [nucleotide binding] 176280005833 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 176280005834 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 176280005835 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 176280005836 Predicted transcriptional regulators [Transcription]; Region: COG1695 176280005837 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 176280005838 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 176280005839 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 176280005840 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 176280005841 homotetramer interface [polypeptide binding]; other site 176280005842 FMN binding site [chemical binding]; other site 176280005843 homodimer contacts [polypeptide binding]; other site 176280005844 putative active site [active] 176280005845 putative substrate binding site [chemical binding]; other site 176280005846 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 176280005847 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 176280005848 oligomer interface [polypeptide binding]; other site 176280005849 metal binding site [ion binding]; metal-binding site 176280005850 metal binding site [ion binding]; metal-binding site 176280005851 putative Cl binding site [ion binding]; other site 176280005852 aspartate ring; other site 176280005853 hydrophobic gate; other site 176280005854 periplasmic entrance; other site 176280005855 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 176280005856 active site 176280005857 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 176280005858 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 176280005859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280005860 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 176280005861 putative substrate translocation pore; other site 176280005862 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 176280005863 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 176280005864 HlyD family secretion protein; Region: HlyD_3; pfam13437 176280005865 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 176280005866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176280005867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280005868 putative substrate translocation pore; other site 176280005869 Predicted membrane protein [Function unknown]; Region: COG4640 176280005870 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 176280005871 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176280005872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176280005873 putative DNA binding site [nucleotide binding]; other site 176280005874 putative Zn2+ binding site [ion binding]; other site 176280005875 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 176280005876 Uncharacterized conserved protein [Function unknown]; Region: COG1434 176280005877 putative active site [active] 176280005878 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176280005879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176280005880 Walker A/P-loop; other site 176280005881 ATP binding site [chemical binding]; other site 176280005882 Q-loop/lid; other site 176280005883 ABC transporter signature motif; other site 176280005884 Walker B; other site 176280005885 D-loop; other site 176280005886 H-loop/switch region; other site 176280005887 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 176280005888 FtsX-like permease family; Region: FtsX; pfam02687 176280005889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176280005890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280005891 active site 176280005892 phosphorylation site [posttranslational modification] 176280005893 intermolecular recognition site; other site 176280005894 dimerization interface [polypeptide binding]; other site 176280005895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176280005896 DNA binding site [nucleotide binding] 176280005897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176280005898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 176280005899 dimerization interface [polypeptide binding]; other site 176280005900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280005901 ATP binding site [chemical binding]; other site 176280005902 Mg2+ binding site [ion binding]; other site 176280005903 G-X-G motif; other site 176280005904 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 176280005905 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 176280005906 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176280005907 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 176280005908 putative ADP-binding pocket [chemical binding]; other site 176280005909 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 176280005910 L-lactate permease; Region: Lactate_perm; cl00701 176280005911 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176280005912 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 176280005913 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 176280005914 active site 176280005915 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176280005916 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 176280005917 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 176280005918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280005919 Coenzyme A binding pocket [chemical binding]; other site 176280005920 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 176280005921 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 176280005922 putative NADP binding site [chemical binding]; other site 176280005923 putative dimer interface [polypeptide binding]; other site 176280005924 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 176280005925 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 176280005926 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 176280005927 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 176280005928 CopC domain; Region: CopC; pfam04234 176280005929 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 176280005930 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 176280005931 Cl binding site [ion binding]; other site 176280005932 oligomer interface [polypeptide binding]; other site 176280005933 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 176280005934 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176280005935 active site turn [active] 176280005936 phosphorylation site [posttranslational modification] 176280005937 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176280005938 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 176280005939 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176280005940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 176280005941 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 176280005942 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 176280005943 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 176280005944 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 176280005945 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 176280005946 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 176280005947 dimer interface [polypeptide binding]; other site 176280005948 FMN binding site [chemical binding]; other site 176280005949 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176280005950 MarR family; Region: MarR_2; pfam12802 176280005951 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 176280005952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280005953 putative substrate translocation pore; other site 176280005954 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 176280005955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280005956 active site 176280005957 phosphorylation site [posttranslational modification] 176280005958 intermolecular recognition site; other site 176280005959 dimerization interface [polypeptide binding]; other site 176280005960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 176280005961 DNA binding residues [nucleotide binding] 176280005962 dimerization interface [polypeptide binding]; other site 176280005963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 176280005964 Histidine kinase; Region: HisKA_3; pfam07730 176280005965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280005966 ATP binding site [chemical binding]; other site 176280005967 Mg2+ binding site [ion binding]; other site 176280005968 G-X-G motif; other site 176280005969 GAF domain; Region: GAF; cl17456 176280005970 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 176280005971 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 176280005972 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 176280005973 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 176280005974 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 176280005975 [4Fe-4S] binding site [ion binding]; other site 176280005976 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 176280005977 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 176280005978 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 176280005979 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 176280005980 molybdopterin cofactor binding site; other site 176280005981 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 176280005982 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 176280005983 active site 176280005984 SAM binding site [chemical binding]; other site 176280005985 homodimer interface [polypeptide binding]; other site 176280005986 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 176280005987 [2Fe-2S] cluster binding site [ion binding]; other site 176280005988 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 176280005989 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176280005990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280005991 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 176280005992 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 176280005993 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 176280005994 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 176280005995 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 176280005996 putative active site [active] 176280005997 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 176280005998 active site 176280005999 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 176280006000 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 176280006001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280006002 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280006003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280006004 Coenzyme A binding pocket [chemical binding]; other site 176280006005 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 176280006006 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 176280006007 putative hydrophobic ligand binding site [chemical binding]; other site 176280006008 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 176280006009 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 176280006010 catalytic residues [active] 176280006011 FemAB family; Region: FemAB; pfam02388 176280006012 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 176280006013 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: vorA; PRK08366 176280006014 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 176280006015 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 176280006016 Walker A/P-loop; other site 176280006017 ATP binding site [chemical binding]; other site 176280006018 Q-loop/lid; other site 176280006019 ABC transporter signature motif; other site 176280006020 Walker B; other site 176280006021 D-loop; other site 176280006022 H-loop/switch region; other site 176280006023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280006024 dimer interface [polypeptide binding]; other site 176280006025 conserved gate region; other site 176280006026 putative PBP binding loops; other site 176280006027 ABC-ATPase subunit interface; other site 176280006028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 176280006029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 176280006030 substrate binding pocket [chemical binding]; other site 176280006031 membrane-bound complex binding site; other site 176280006032 hinge residues; other site 176280006033 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 176280006034 catalytic core [active] 176280006035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 176280006036 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 176280006037 Cation efflux family; Region: Cation_efflux; pfam01545 176280006038 Predicted membrane protein [Function unknown]; Region: COG2246 176280006039 GtrA-like protein; Region: GtrA; pfam04138 176280006040 glycerate kinase; Region: TIGR00045 176280006041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280006042 putative substrate translocation pore; other site 176280006043 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 176280006044 putative phosphoesterase; Region: acc_ester; TIGR03729 176280006045 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 176280006046 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 176280006047 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 176280006048 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 176280006049 Beta-lactamase; Region: Beta-lactamase; pfam00144 176280006050 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 176280006051 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 176280006052 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 176280006053 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 176280006054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280006055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280006056 putative substrate translocation pore; other site 176280006057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280006058 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 176280006059 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 176280006060 GAF domain; Region: GAF_3; pfam13492 176280006061 Histidine kinase; Region: His_kinase; pfam06580 176280006062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280006063 Mg2+ binding site [ion binding]; other site 176280006064 G-X-G motif; other site 176280006065 two-component response regulator; Provisional; Region: PRK14084 176280006066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280006067 active site 176280006068 phosphorylation site [posttranslational modification] 176280006069 intermolecular recognition site; other site 176280006070 dimerization interface [polypeptide binding]; other site 176280006071 LytTr DNA-binding domain; Region: LytTR; pfam04397 176280006072 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 176280006073 antiholin-like protein LrgB; Provisional; Region: PRK04288 176280006074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280006075 dimer interface [polypeptide binding]; other site 176280006076 conserved gate region; other site 176280006077 ABC-ATPase subunit interface; other site 176280006078 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 176280006079 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 176280006080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280006081 dimer interface [polypeptide binding]; other site 176280006082 conserved gate region; other site 176280006083 putative PBP binding loops; other site 176280006084 ABC-ATPase subunit interface; other site 176280006085 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 176280006086 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 176280006087 Walker A/P-loop; other site 176280006088 ATP binding site [chemical binding]; other site 176280006089 Q-loop/lid; other site 176280006090 ABC transporter signature motif; other site 176280006091 Walker B; other site 176280006092 D-loop; other site 176280006093 H-loop/switch region; other site 176280006094 FOG: CBS domain [General function prediction only]; Region: COG0517 176280006095 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 176280006096 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 176280006097 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 176280006098 putative NAD(P) binding site [chemical binding]; other site 176280006099 catalytic Zn binding site [ion binding]; other site 176280006100 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 176280006101 amino acid transporter; Region: 2A0306; TIGR00909 176280006102 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 176280006103 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 176280006104 substrate binding pocket [chemical binding]; other site 176280006105 catalytic triad [active] 176280006106 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 176280006107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280006108 putative substrate translocation pore; other site 176280006109 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 176280006110 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 176280006111 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176280006112 Walker A/P-loop; other site 176280006113 ATP binding site [chemical binding]; other site 176280006114 Q-loop/lid; other site 176280006115 ABC transporter signature motif; other site 176280006116 Walker B; other site 176280006117 D-loop; other site 176280006118 H-loop/switch region; other site 176280006119 CAAX protease self-immunity; Region: Abi; pfam02517 176280006120 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 176280006121 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 176280006122 active site 176280006123 FMN binding site [chemical binding]; other site 176280006124 substrate binding site [chemical binding]; other site 176280006125 3Fe-4S cluster binding site [ion binding]; other site 176280006126 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 176280006127 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 176280006128 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 176280006129 oligomer interface [polypeptide binding]; other site 176280006130 active site 176280006131 metal binding site [ion binding]; metal-binding site 176280006132 short chain dehydrogenase; Validated; Region: PRK08589 176280006133 classical (c) SDRs; Region: SDR_c; cd05233 176280006134 NAD(P) binding site [chemical binding]; other site 176280006135 active site 176280006136 exopolyphosphatase; Region: exo_poly_only; TIGR03706 176280006137 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 176280006138 nucleotide binding site [chemical binding]; other site 176280006139 polyphosphate kinase; Provisional; Region: PRK05443 176280006140 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 176280006141 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 176280006142 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 176280006143 putative domain interface [polypeptide binding]; other site 176280006144 putative active site [active] 176280006145 catalytic site [active] 176280006146 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 176280006147 putative domain interface [polypeptide binding]; other site 176280006148 putative active site [active] 176280006149 catalytic site [active] 176280006150 acetylornithine deacetylase; Validated; Region: PRK08596 176280006151 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 176280006152 metal binding site [ion binding]; metal-binding site 176280006153 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 176280006154 classical (c) SDRs; Region: SDR_c; cd05233 176280006155 NAD(P) binding site [chemical binding]; other site 176280006156 active site 176280006157 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 176280006158 PLD-like domain; Region: PLDc_2; pfam13091 176280006159 putative active site [active] 176280006160 catalytic site [active] 176280006161 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 176280006162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176280006163 ATP binding site [chemical binding]; other site 176280006164 putative Mg++ binding site [ion binding]; other site 176280006165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280006166 nucleotide binding region [chemical binding]; other site 176280006167 ATP-binding site [chemical binding]; other site 176280006168 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 176280006169 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 176280006170 active site 176280006171 8-oxo-dGMP binding site [chemical binding]; other site 176280006172 nudix motif; other site 176280006173 metal binding site [ion binding]; metal-binding site 176280006174 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 176280006175 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 176280006176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176280006177 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 176280006178 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 176280006179 active site 176280006180 substrate binding site [chemical binding]; other site 176280006181 metal binding site [ion binding]; metal-binding site 176280006182 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 176280006183 tetramer interface; other site 176280006184 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 176280006185 active site 176280006186 fructuronate transporter; Provisional; Region: PRK10034; cl15264 176280006187 gluconate transporter; Region: gntP; TIGR00791 176280006188 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 176280006189 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 176280006190 N- and C-terminal domain interface [polypeptide binding]; other site 176280006191 active site 176280006192 catalytic site [active] 176280006193 metal binding site [ion binding]; metal-binding site 176280006194 carbohydrate binding site [chemical binding]; other site 176280006195 ATP binding site [chemical binding]; other site 176280006196 Transcriptional regulators [Transcription]; Region: GntR; COG1802 176280006197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 176280006198 DNA-binding site [nucleotide binding]; DNA binding site 176280006199 FCD domain; Region: FCD; pfam07729 176280006200 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 176280006201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280006202 putative substrate translocation pore; other site 176280006203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280006204 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 176280006205 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 176280006206 DNA binding residues [nucleotide binding] 176280006207 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 176280006208 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 176280006209 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 176280006210 active site 176280006211 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 176280006212 synthetase active site [active] 176280006213 NTP binding site [chemical binding]; other site 176280006214 metal binding site [ion binding]; metal-binding site 176280006215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 176280006216 Predicted membrane protein [Function unknown]; Region: COG1289 176280006217 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 176280006218 Uncharacterized conserved protein [Function unknown]; Region: COG1359 176280006219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280006220 D-galactonate transporter; Region: 2A0114; TIGR00893 176280006221 putative substrate translocation pore; other site 176280006222 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 176280006223 active site 176280006224 pyrophosphate binding site [ion binding]; other site 176280006225 thiamine phosphate binding site [chemical binding]; other site 176280006226 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 176280006227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 176280006228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176280006229 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 176280006230 thiS-thiF/thiG interaction site; other site 176280006231 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 176280006232 ThiS interaction site; other site 176280006233 putative active site [active] 176280006234 tetramer interface [polypeptide binding]; other site 176280006235 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 176280006236 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 176280006237 ATP binding site [chemical binding]; other site 176280006238 substrate interface [chemical binding]; other site 176280006239 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 176280006240 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 176280006241 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 176280006242 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 176280006243 Uncharacterized membrane protein [Function unknown]; Region: COG3949 176280006244 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 176280006245 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 176280006246 NAD binding site [chemical binding]; other site 176280006247 catalytic residues [active] 176280006248 substrate binding site [chemical binding]; other site 176280006249 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 176280006250 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 176280006251 metal binding site [ion binding]; metal-binding site 176280006252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280006253 Coenzyme A binding pocket [chemical binding]; other site 176280006254 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 176280006255 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 176280006256 putative metal binding site [ion binding]; other site 176280006257 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 176280006258 active site 176280006259 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 176280006260 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 176280006261 NAD(P) binding site [chemical binding]; other site 176280006262 catalytic residues [active] 176280006263 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 176280006264 dimer interface [polypeptide binding]; other site 176280006265 FMN binding site [chemical binding]; other site 176280006266 D-lactate dehydrogenase; Provisional; Region: PRK12480 176280006267 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 176280006268 homodimer interface [polypeptide binding]; other site 176280006269 ligand binding site [chemical binding]; other site 176280006270 NAD binding site [chemical binding]; other site 176280006271 catalytic site [active] 176280006272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280006273 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 176280006274 active site 176280006275 motif I; other site 176280006276 motif II; other site 176280006277 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 176280006278 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 176280006279 active site 176280006280 catalytic site [active] 176280006281 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 176280006282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280006283 Coenzyme A binding pocket [chemical binding]; other site 176280006284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280006285 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280006286 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 176280006287 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 176280006288 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 176280006289 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 176280006290 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 176280006291 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 176280006292 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 176280006293 N- and C-terminal domain interface [polypeptide binding]; other site 176280006294 D-xylulose kinase; Region: XylB; TIGR01312 176280006295 active site 176280006296 MgATP binding site [chemical binding]; other site 176280006297 catalytic site [active] 176280006298 metal binding site [ion binding]; metal-binding site 176280006299 xylulose binding site [chemical binding]; other site 176280006300 homodimer interface [polypeptide binding]; other site 176280006301 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 176280006302 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 176280006303 substrate binding site [chemical binding]; other site 176280006304 dimer interface [polypeptide binding]; other site 176280006305 ATP binding site [chemical binding]; other site 176280006306 D-ribose pyranase; Provisional; Region: PRK11797 176280006307 Sugar transport protein; Region: Sugar_transport; pfam06800 176280006308 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 176280006309 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 176280006310 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 176280006311 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 176280006312 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 176280006313 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 176280006314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176280006315 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 176280006316 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 176280006317 nucleophilic elbow; other site 176280006318 catalytic triad; other site 176280006319 Uncharacterized conserved protein [Function unknown]; Region: COG1284 176280006320 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 176280006321 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 176280006322 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176280006323 catalytic residues [active] 176280006324 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 176280006325 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 176280006326 catalytic Zn binding site [ion binding]; other site 176280006327 structural Zn binding site [ion binding]; other site 176280006328 NAD(P) binding site [chemical binding]; other site 176280006329 CAAX protease self-immunity; Region: Abi; pfam02517 176280006330 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 176280006331 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176280006332 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176280006333 active site turn [active] 176280006334 phosphorylation site [posttranslational modification] 176280006335 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 176280006336 HPr interaction site; other site 176280006337 glycerol kinase (GK) interaction site [polypeptide binding]; other site 176280006338 active site 176280006339 phosphorylation site [posttranslational modification] 176280006340 pyruvate oxidase; Provisional; Region: PRK08611 176280006341 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 176280006342 PYR/PP interface [polypeptide binding]; other site 176280006343 dimer interface [polypeptide binding]; other site 176280006344 tetramer interface [polypeptide binding]; other site 176280006345 TPP binding site [chemical binding]; other site 176280006346 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 176280006347 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 176280006348 TPP-binding site [chemical binding]; other site 176280006349 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 176280006350 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 176280006351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176280006352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176280006353 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 176280006354 putative dimerization interface [polypeptide binding]; other site 176280006355 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 176280006356 Surface antigen [General function prediction only]; Region: COG3942 176280006357 CHAP domain; Region: CHAP; pfam05257 176280006358 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 176280006359 homodimer interface [polypeptide binding]; other site 176280006360 catalytic residues [active] 176280006361 NAD binding site [chemical binding]; other site 176280006362 substrate binding pocket [chemical binding]; other site 176280006363 flexible flap; other site 176280006364 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 176280006365 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 176280006366 dimer interface [polypeptide binding]; other site 176280006367 active site 176280006368 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 176280006369 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 176280006370 DNA binding site [nucleotide binding] 176280006371 active site 176280006372 Virus attachment protein p12 family; Region: P12; pfam12669 176280006373 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 176280006374 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 176280006375 G1 box; other site 176280006376 GTP/Mg2+ binding site [chemical binding]; other site 176280006377 Switch I region; other site 176280006378 G2 box; other site 176280006379 G3 box; other site 176280006380 Switch II region; other site 176280006381 G4 box; other site 176280006382 G5 box; other site 176280006383 Nucleoside recognition; Region: Gate; pfam07670 176280006384 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 176280006385 Nucleoside recognition; Region: Gate; pfam07670 176280006386 FeoA domain; Region: FeoA; cl00838 176280006387 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 176280006388 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 176280006389 Glutamate binding site [chemical binding]; other site 176280006390 homodimer interface [polypeptide binding]; other site 176280006391 NAD binding site [chemical binding]; other site 176280006392 catalytic residues [active] 176280006393 short chain dehydrogenase; Provisional; Region: PRK06701 176280006394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176280006395 NAD(P) binding site [chemical binding]; other site 176280006396 active site 176280006397 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 176280006398 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 176280006399 metal-binding site [ion binding] 176280006400 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 176280006401 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 176280006402 metal-binding site [ion binding] 176280006403 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 176280006404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176280006405 motif II; other site 176280006406 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 176280006407 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 176280006408 metal-binding site [ion binding] 176280006409 D-lactate dehydrogenase; Validated; Region: PRK08605 176280006410 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 176280006411 homodimer interface [polypeptide binding]; other site 176280006412 ligand binding site [chemical binding]; other site 176280006413 NAD binding site [chemical binding]; other site 176280006414 catalytic site [active] 176280006415 transaminase; Reviewed; Region: PRK08068 176280006416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 176280006417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280006418 homodimer interface [polypeptide binding]; other site 176280006419 catalytic residue [active] 176280006420 Surface antigen [General function prediction only]; Region: COG3942 176280006421 CHAP domain; Region: CHAP; pfam05257 176280006422 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 176280006423 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 176280006424 catalytic triad [active] 176280006425 catalytic triad [active] 176280006426 oxyanion hole [active] 176280006427 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 176280006428 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 176280006429 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 176280006430 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 176280006431 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 176280006432 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 176280006433 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 176280006434 Phosphotransferase enzyme family; Region: APH; pfam01636 176280006435 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 176280006436 active site 176280006437 ATP binding site [chemical binding]; other site 176280006438 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 176280006439 active site 176280006440 ATP binding site [chemical binding]; other site 176280006441 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 176280006442 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 176280006443 quinone interaction residues [chemical binding]; other site 176280006444 active site 176280006445 catalytic residues [active] 176280006446 FMN binding site [chemical binding]; other site 176280006447 substrate binding site [chemical binding]; other site 176280006448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 176280006449 Predicted membrane protein [Function unknown]; Region: COG4640 176280006450 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 176280006451 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 176280006452 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 176280006453 tetramerization interface [polypeptide binding]; other site 176280006454 active site 176280006455 Pantoate-beta-alanine ligase; Region: PanC; cd00560 176280006456 pantoate--beta-alanine ligase; Region: panC; TIGR00018 176280006457 active site 176280006458 ATP-binding site [chemical binding]; other site 176280006459 pantoate-binding site; other site 176280006460 HXXH motif; other site 176280006461 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 176280006462 oligomerization interface [polypeptide binding]; other site 176280006463 active site 176280006464 metal binding site [ion binding]; metal-binding site 176280006465 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 176280006466 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 176280006467 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 176280006468 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 176280006469 acetolactate synthase; Reviewed; Region: PRK08617 176280006470 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 176280006471 PYR/PP interface [polypeptide binding]; other site 176280006472 dimer interface [polypeptide binding]; other site 176280006473 TPP binding site [chemical binding]; other site 176280006474 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 176280006475 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 176280006476 TPP-binding site [chemical binding]; other site 176280006477 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 176280006478 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 176280006479 dimer interface [polypeptide binding]; other site 176280006480 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176280006481 NAD binding site [chemical binding]; other site 176280006482 substrate binding site [chemical binding]; other site 176280006483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176280006484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176280006485 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 176280006486 putative dimerization interface [polypeptide binding]; other site 176280006487 amino acid transporter; Region: 2A0306; TIGR00909 176280006488 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 176280006489 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176280006490 inhibitor-cofactor binding pocket; inhibition site 176280006491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280006492 catalytic residue [active] 176280006493 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 176280006494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280006495 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280006496 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 176280006497 catalytic residue [active] 176280006498 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 176280006499 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 176280006500 PEP synthetase regulatory protein; Provisional; Region: PRK05339 176280006501 pyruvate phosphate dikinase; Provisional; Region: PRK09279 176280006502 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 176280006503 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 176280006504 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 176280006505 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 176280006506 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 176280006507 acyl-activating enzyme (AAE) consensus motif; other site 176280006508 AMP binding site [chemical binding]; other site 176280006509 active site 176280006510 CoA binding site [chemical binding]; other site 176280006511 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 176280006512 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 176280006513 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176280006514 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 176280006515 metal binding site [ion binding]; metal-binding site 176280006516 dimer interface [polypeptide binding]; other site 176280006517 choline dehydrogenase; Validated; Region: PRK02106 176280006518 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 176280006519 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 176280006520 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 176280006521 tetramerization interface [polypeptide binding]; other site 176280006522 NAD(P) binding site [chemical binding]; other site 176280006523 catalytic residues [active] 176280006524 Predicted transcriptional regulators [Transcription]; Region: COG1510 176280006525 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 176280006526 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 176280006527 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 176280006528 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 176280006529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176280006530 FeS/SAM binding site; other site 176280006531 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 176280006532 Class III ribonucleotide reductase; Region: RNR_III; cd01675 176280006533 effector binding site; other site 176280006534 active site 176280006535 Zn binding site [ion binding]; other site 176280006536 glycine loop; other site 176280006537 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 176280006538 ligand-binding site [chemical binding]; other site 176280006539 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 176280006540 ATP-sulfurylase; Region: ATPS; cd00517 176280006541 active site 176280006542 HXXH motif; other site 176280006543 flexible loop; other site 176280006544 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 176280006545 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 176280006546 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 176280006547 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 176280006548 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 176280006549 active site 176280006550 SAM binding site [chemical binding]; other site 176280006551 homodimer interface [polypeptide binding]; other site 176280006552 sulfite reductase subunit beta; Provisional; Region: PRK13504 176280006553 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 176280006554 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 176280006555 Protein of unknown function (DUF1636); Region: DUF1636; cl17843 176280006556 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 176280006557 Flavodoxin; Region: Flavodoxin_1; pfam00258 176280006558 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 176280006559 FAD binding pocket [chemical binding]; other site 176280006560 FAD binding motif [chemical binding]; other site 176280006561 catalytic residues [active] 176280006562 NAD binding pocket [chemical binding]; other site 176280006563 phosphate binding motif [ion binding]; other site 176280006564 beta-alpha-beta structure motif; other site 176280006565 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 176280006566 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 176280006567 Active Sites [active] 176280006568 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 176280006569 catalytic residues [active] 176280006570 dimer interface [polypeptide binding]; other site 176280006571 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 176280006572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280006573 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176280006574 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176280006575 MarR family; Region: MarR; pfam01047 176280006576 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 176280006577 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 176280006578 Double zinc ribbon; Region: DZR; pfam12773 176280006579 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 176280006580 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 176280006581 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176280006582 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176280006583 Walker A/P-loop; other site 176280006584 ATP binding site [chemical binding]; other site 176280006585 Q-loop/lid; other site 176280006586 ABC transporter signature motif; other site 176280006587 Walker B; other site 176280006588 D-loop; other site 176280006589 H-loop/switch region; other site 176280006590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176280006591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176280006592 ATP binding site [chemical binding]; other site 176280006593 Mg2+ binding site [ion binding]; other site 176280006594 G-X-G motif; other site 176280006595 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176280006596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176280006597 active site 176280006598 phosphorylation site [posttranslational modification] 176280006599 intermolecular recognition site; other site 176280006600 dimerization interface [polypeptide binding]; other site 176280006601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176280006602 DNA binding site [nucleotide binding] 176280006603 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 176280006604 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 176280006605 dimer interface [polypeptide binding]; other site 176280006606 active site 176280006607 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 176280006608 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 176280006609 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 176280006610 putative NAD(P) binding site [chemical binding]; other site 176280006611 putative active site [active] 176280006612 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176280006613 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 176280006614 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176280006615 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 176280006616 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 176280006617 Protein of unknown function (DUF867); Region: DUF867; pfam05908 176280006618 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 176280006619 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 176280006620 AAA domain; Region: AAA_23; pfam13476 176280006621 AAA domain; Region: AAA_21; pfam13304 176280006622 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 176280006623 catalytic nucleophile [active] 176280006624 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 176280006625 Transposase IS200 like; Region: Y1_Tnp; pfam01797 176280006626 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176280006627 MarR family; Region: MarR_2; pfam12802 176280006628 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 176280006629 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 176280006630 dimer interface [polypeptide binding]; other site 176280006631 PYR/PP interface [polypeptide binding]; other site 176280006632 TPP binding site [chemical binding]; other site 176280006633 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 176280006634 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 176280006635 TPP-binding site [chemical binding]; other site 176280006636 dimer interface [polypeptide binding]; other site 176280006637 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 176280006638 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 176280006639 putative active site [active] 176280006640 putative metal binding site [ion binding]; other site 176280006641 Predicted esterase [General function prediction only]; Region: COG0627 176280006642 S-formylglutathione hydrolase; Region: PLN02442 176280006643 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 176280006644 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 176280006645 ligand binding site [chemical binding]; other site 176280006646 flexible hinge region; other site 176280006647 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 176280006648 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 176280006649 ornithine carbamoyltransferase; Validated; Region: PRK02102 176280006650 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 176280006651 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 176280006652 arginine deiminase; Provisional; Region: PRK01388 176280006653 Arginine repressor [Transcription]; Region: ArgR; COG1438 176280006654 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 176280006655 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 176280006656 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 176280006657 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 176280006658 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 176280006659 active site 176280006660 Zn binding site [ion binding]; other site 176280006661 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 176280006662 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 176280006663 metal binding site [ion binding]; metal-binding site 176280006664 dimer interface [polypeptide binding]; other site 176280006665 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 176280006666 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 176280006667 acetoin reductase; Validated; Region: PRK08643 176280006668 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 176280006669 NAD binding site [chemical binding]; other site 176280006670 homotetramer interface [polypeptide binding]; other site 176280006671 homodimer interface [polypeptide binding]; other site 176280006672 active site 176280006673 substrate binding site [chemical binding]; other site 176280006674 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176280006675 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 176280006676 HTH domain; Region: HTH_11; pfam08279 176280006677 PRD domain; Region: PRD; pfam00874 176280006678 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 176280006679 active site 176280006680 P-loop; other site 176280006681 phosphorylation site [posttranslational modification] 176280006682 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 176280006683 active site 176280006684 phosphorylation site [posttranslational modification] 176280006685 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 176280006686 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 176280006687 active site 176280006688 P-loop; other site 176280006689 phosphorylation site [posttranslational modification] 176280006690 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 176280006691 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 176280006692 active site 176280006693 phosphorylation site [posttranslational modification] 176280006694 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 176280006695 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 176280006696 Predicted membrane protein [Function unknown]; Region: COG1511 176280006697 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 176280006698 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 176280006699 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 176280006700 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 176280006701 CHAP domain; Region: CHAP; pfam05257 176280006702 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 176280006703 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 176280006704 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 176280006705 Flavin Reductases; Region: FlaRed; cl00801 176280006706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280006707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176280006708 putative substrate translocation pore; other site 176280006709 methionine sulfoxide reductase A; Provisional; Region: PRK05528 176280006710 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 176280006711 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 176280006712 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 176280006713 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 176280006714 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 176280006715 DEAD/DEAH box helicase; Region: DEAD; pfam00270 176280006716 ATP binding site [chemical binding]; other site 176280006717 putative Mg++ binding site [ion binding]; other site 176280006718 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 176280006719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280006720 nucleotide binding region [chemical binding]; other site 176280006721 ATP-binding site [chemical binding]; other site 176280006722 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 176280006723 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 176280006724 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 176280006725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 176280006726 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 176280006727 SecY translocase; Region: SecY; pfam00344 176280006728 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 176280006729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280006730 dimer interface [polypeptide binding]; other site 176280006731 conserved gate region; other site 176280006732 putative PBP binding loops; other site 176280006733 ABC-ATPase subunit interface; other site 176280006734 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 176280006735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280006736 dimer interface [polypeptide binding]; other site 176280006737 conserved gate region; other site 176280006738 ABC-ATPase subunit interface; other site 176280006739 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 176280006740 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 176280006741 Walker A/P-loop; other site 176280006742 ATP binding site [chemical binding]; other site 176280006743 Q-loop/lid; other site 176280006744 ABC transporter signature motif; other site 176280006745 Walker B; other site 176280006746 D-loop; other site 176280006747 H-loop/switch region; other site 176280006748 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 176280006749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 176280006750 substrate binding pocket [chemical binding]; other site 176280006751 membrane-bound complex binding site; other site 176280006752 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 176280006753 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 176280006754 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 176280006755 active site 176280006756 metal binding site [ion binding]; metal-binding site 176280006757 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 176280006758 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 176280006759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280006760 putative substrate translocation pore; other site 176280006761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176280006762 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176280006763 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 176280006764 predicted active site [active] 176280006765 catalytic triad [active] 176280006766 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 176280006767 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 176280006768 active site 176280006769 multimer interface [polypeptide binding]; other site 176280006770 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 176280006771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 176280006772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280006773 homodimer interface [polypeptide binding]; other site 176280006774 catalytic residue [active] 176280006775 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 176280006776 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 176280006777 dimer interface [polypeptide binding]; other site 176280006778 putative anticodon binding site; other site 176280006779 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 176280006780 motif 1; other site 176280006781 active site 176280006782 motif 2; other site 176280006783 motif 3; other site 176280006784 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 176280006785 catalytic center binding site [active] 176280006786 ATP binding site [chemical binding]; other site 176280006787 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 176280006788 homooctamer interface [polypeptide binding]; other site 176280006789 active site 176280006790 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 176280006791 dihydropteroate synthase; Region: DHPS; TIGR01496 176280006792 substrate binding pocket [chemical binding]; other site 176280006793 dimer interface [polypeptide binding]; other site 176280006794 inhibitor binding site; inhibition site 176280006795 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 176280006796 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 176280006797 dimer interface [polypeptide binding]; other site 176280006798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280006799 catalytic residue [active] 176280006800 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 176280006801 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 176280006802 dimerization interface [polypeptide binding]; other site 176280006803 domain crossover interface; other site 176280006804 redox-dependent activation switch; other site 176280006805 FtsH Extracellular; Region: FtsH_ext; pfam06480 176280006806 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 176280006807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280006808 Walker A motif; other site 176280006809 ATP binding site [chemical binding]; other site 176280006810 Walker B motif; other site 176280006811 arginine finger; other site 176280006812 Peptidase family M41; Region: Peptidase_M41; pfam01434 176280006813 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 176280006814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176280006815 active site 176280006816 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 176280006817 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 176280006818 Ligand Binding Site [chemical binding]; other site 176280006819 TilS substrate C-terminal domain; Region: TilS_C; smart00977 176280006820 hypothetical protein; Provisional; Region: PRK08582 176280006821 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 176280006822 RNA binding site [nucleotide binding]; other site 176280006823 Septum formation initiator; Region: DivIC; pfam04977 176280006824 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 176280006825 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176280006826 RNA binding surface [nucleotide binding]; other site 176280006827 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 176280006828 putative SAM binding site [chemical binding]; other site 176280006829 putative homodimer interface [polypeptide binding]; other site 176280006830 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 176280006831 homodimer interface [polypeptide binding]; other site 176280006832 metal binding site [ion binding]; metal-binding site 176280006833 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 176280006834 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 176280006835 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 176280006836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176280006837 ATP binding site [chemical binding]; other site 176280006838 putative Mg++ binding site [ion binding]; other site 176280006839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176280006840 nucleotide binding region [chemical binding]; other site 176280006841 ATP-binding site [chemical binding]; other site 176280006842 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 176280006843 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 176280006844 putative active site [active] 176280006845 catalytic residue [active] 176280006846 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 176280006847 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 176280006848 5S rRNA interface [nucleotide binding]; other site 176280006849 CTC domain interface [polypeptide binding]; other site 176280006850 L16 interface [polypeptide binding]; other site 176280006851 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 176280006852 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 176280006853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176280006854 active site 176280006855 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 176280006856 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 176280006857 Substrate binding site; other site 176280006858 Mg++ binding site; other site 176280006859 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 176280006860 active site 176280006861 substrate binding site [chemical binding]; other site 176280006862 CoA binding site [chemical binding]; other site 176280006863 regulatory protein SpoVG; Reviewed; Region: PRK13259 176280006864 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 176280006865 homotrimer interaction site [polypeptide binding]; other site 176280006866 putative active site [active] 176280006867 pur operon repressor; Provisional; Region: PRK09213 176280006868 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 176280006869 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176280006870 active site 176280006871 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 176280006872 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 176280006873 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 176280006874 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 176280006875 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 176280006876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280006877 S-adenosylmethionine binding site [chemical binding]; other site 176280006878 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 176280006879 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 176280006880 putative active site [active] 176280006881 putative metal binding site [ion binding]; other site 176280006882 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 176280006883 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 176280006884 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 176280006885 active site 176280006886 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 176280006887 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 176280006888 active site 176280006889 HIGH motif; other site 176280006890 KMSKS motif; other site 176280006891 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 176280006892 tRNA binding surface [nucleotide binding]; other site 176280006893 anticodon binding site; other site 176280006894 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 176280006895 dimer interface [polypeptide binding]; other site 176280006896 putative tRNA-binding site [nucleotide binding]; other site 176280006897 Predicted methyltransferases [General function prediction only]; Region: COG0313 176280006898 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 176280006899 putative SAM binding site [chemical binding]; other site 176280006900 putative homodimer interface [polypeptide binding]; other site 176280006901 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 176280006902 GIY-YIG motif/motif A; other site 176280006903 putative active site [active] 176280006904 putative metal binding site [ion binding]; other site 176280006905 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 176280006906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280006907 S-adenosylmethionine binding site [chemical binding]; other site 176280006908 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 176280006909 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 176280006910 DNA polymerase III subunit delta'; Validated; Region: PRK08058 176280006911 DNA polymerase III subunit delta'; Validated; Region: PRK08485 176280006912 Protein of unknown function (DUF970); Region: DUF970; pfam06153 176280006913 thymidylate kinase; Validated; Region: tmk; PRK00698 176280006914 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 176280006915 TMP-binding site; other site 176280006916 ATP-binding site [chemical binding]; other site 176280006917 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 176280006918 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 176280006919 homodimer interface [polypeptide binding]; other site 176280006920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280006921 catalytic residue [active] 176280006922 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 176280006923 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 176280006924 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 176280006925 recombination protein RecR; Reviewed; Region: recR; PRK00076 176280006926 RecR protein; Region: RecR; pfam02132 176280006927 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 176280006928 putative active site [active] 176280006929 putative metal-binding site [ion binding]; other site 176280006930 tetramer interface [polypeptide binding]; other site 176280006931 hypothetical protein; Validated; Region: PRK00153 176280006932 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 176280006933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176280006934 Walker A motif; other site 176280006935 ATP binding site [chemical binding]; other site 176280006936 Walker B motif; other site 176280006937 arginine finger; other site 176280006938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176280006939 Coenzyme A binding pocket [chemical binding]; other site 176280006940 Predicted membrane protein [Function unknown]; Region: COG2855 176280006941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176280006942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176280006943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 176280006944 dimerization interface [polypeptide binding]; other site 176280006945 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 176280006946 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 176280006947 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 176280006948 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 176280006949 active site 176280006950 dimer interface [polypeptide binding]; other site 176280006951 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 176280006952 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 176280006953 active site 176280006954 FMN binding site [chemical binding]; other site 176280006955 substrate binding site [chemical binding]; other site 176280006956 3Fe-4S cluster binding site [ion binding]; other site 176280006957 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 176280006958 domain interface; other site 176280006959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176280006960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176280006961 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 176280006962 dimerization interface [polypeptide binding]; other site 176280006963 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 176280006964 YibE/F-like protein; Region: YibE_F; cl02259 176280006965 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 176280006966 nudix motif; other site 176280006967 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 176280006968 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 176280006969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176280006970 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176280006971 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176280006972 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176280006973 Surface antigen [General function prediction only]; Region: COG3942 176280006974 CHAP domain; Region: CHAP; pfam05257 176280006975 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 176280006976 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 176280006977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176280006978 dimer interface [polypeptide binding]; other site 176280006979 conserved gate region; other site 176280006980 ABC-ATPase subunit interface; other site 176280006981 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 176280006982 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 176280006983 Walker A/P-loop; other site 176280006984 ATP binding site [chemical binding]; other site 176280006985 Q-loop/lid; other site 176280006986 ABC transporter signature motif; other site 176280006987 Walker B; other site 176280006988 D-loop; other site 176280006989 H-loop/switch region; other site 176280006990 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 176280006991 cystathionine beta-lyase; Provisional; Region: PRK07671 176280006992 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 176280006993 homodimer interface [polypeptide binding]; other site 176280006994 substrate-cofactor binding pocket; other site 176280006995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280006996 catalytic residue [active] 176280006997 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 176280006998 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 176280006999 dimer interface [polypeptide binding]; other site 176280007000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280007001 catalytic residue [active] 176280007002 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 176280007003 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 176280007004 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 176280007005 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 176280007006 putative substrate binding site 2 [chemical binding]; other site 176280007007 putative substrate binding site 1 [chemical binding]; other site 176280007008 Na binding site 1 [ion binding]; other site 176280007009 Na2 binding site [ion binding]; other site 176280007010 Esterase/lipase [General function prediction only]; Region: COG1647 176280007011 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 176280007012 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 176280007013 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 176280007014 active site 176280007015 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 176280007016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 176280007017 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 176280007018 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 176280007019 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176280007020 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 176280007021 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 176280007022 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 176280007023 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 176280007024 dimer interface [polypeptide binding]; other site 176280007025 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 176280007026 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 176280007027 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 176280007028 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 176280007029 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 176280007030 Int/Topo IB signature motif; other site 176280007031 Abi-like protein; Region: Abi_2; pfam07751 176280007032 GMP synthase; Reviewed; Region: guaA; PRK00074 176280007033 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 176280007034 AMP/PPi binding site [chemical binding]; other site 176280007035 candidate oxyanion hole; other site 176280007036 catalytic triad [active] 176280007037 potential glutamine specificity residues [chemical binding]; other site 176280007038 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 176280007039 ATP Binding subdomain [chemical binding]; other site 176280007040 Ligand Binding sites [chemical binding]; other site 176280007041 Dimerization subdomain; other site 176280007042 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 176280007043 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 176280007044 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 176280007045 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 176280007046 active site 176280007047 xanthine permease; Region: pbuX; TIGR03173 176280007048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176280007049 active site 176280007050 Heat induced stress protein YflT; Region: YflT; pfam11181 176280007051 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 176280007052 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 176280007053 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 176280007054 dimer interface [polypeptide binding]; other site 176280007055 FMN binding site [chemical binding]; other site 176280007056 NADPH bind site [chemical binding]; other site 176280007057 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 176280007058 peroxiredoxin; Region: AhpC; TIGR03137 176280007059 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 176280007060 dimer interface [polypeptide binding]; other site 176280007061 decamer (pentamer of dimers) interface [polypeptide binding]; other site 176280007062 catalytic triad [active] 176280007063 peroxidatic and resolving cysteines [active] 176280007064 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 176280007065 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 176280007066 catalytic residue [active] 176280007067 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 176280007068 catalytic residues [active] 176280007069 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176280007070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176280007071 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 176280007072 catalytic core [active] 176280007073 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 176280007074 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 176280007075 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 176280007076 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 176280007077 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 176280007078 dimer interface [polypeptide binding]; other site 176280007079 ssDNA binding site [nucleotide binding]; other site 176280007080 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176280007081 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 176280007082 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 176280007083 active site 176280007084 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 176280007085 GTP-binding protein YchF; Reviewed; Region: PRK09601 176280007086 YchF GTPase; Region: YchF; cd01900 176280007087 G1 box; other site 176280007088 GTP/Mg2+ binding site [chemical binding]; other site 176280007089 Switch I region; other site 176280007090 G2 box; other site 176280007091 Switch II region; other site 176280007092 G3 box; other site 176280007093 G4 box; other site 176280007094 G5 box; other site 176280007095 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 176280007096 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 176280007097 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 176280007098 Mechanosensitive ion channel; Region: MS_channel; pfam00924 176280007099 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 176280007100 ParB-like nuclease domain; Region: ParB; smart00470 176280007101 KorB domain; Region: KorB; pfam08535 176280007102 cystathionine gamma-synthase; Reviewed; Region: PRK08247 176280007103 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 176280007104 homodimer interface [polypeptide binding]; other site 176280007105 substrate-cofactor binding pocket; other site 176280007106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280007107 catalytic residue [active] 176280007108 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 176280007109 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 176280007110 homodimer interface [polypeptide binding]; other site 176280007111 substrate-cofactor binding pocket; other site 176280007112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176280007113 catalytic residue [active] 176280007114 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 176280007115 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 176280007116 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 176280007117 FAD binding site [chemical binding]; other site 176280007118 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 176280007119 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 176280007120 THF binding site; other site 176280007121 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 176280007122 substrate binding site [chemical binding]; other site 176280007123 THF binding site; other site 176280007124 zinc-binding site [ion binding]; other site 176280007125 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 176280007126 putative acyltransferase; Provisional; Region: PRK05790 176280007127 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 176280007128 dimer interface [polypeptide binding]; other site 176280007129 active site 176280007130 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 176280007131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176280007132 non-specific DNA binding site [nucleotide binding]; other site 176280007133 salt bridge; other site 176280007134 sequence-specific DNA binding site [nucleotide binding]; other site 176280007135 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 176280007136 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 176280007137 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176280007138 Walker A/P-loop; other site 176280007139 ATP binding site [chemical binding]; other site 176280007140 Q-loop/lid; other site 176280007141 ABC transporter signature motif; other site 176280007142 Walker B; other site 176280007143 D-loop; other site 176280007144 H-loop/switch region; other site 176280007145 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 176280007146 DinB superfamily; Region: DinB_2; pfam12867 176280007147 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 176280007148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 176280007149 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 176280007150 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 176280007151 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176280007152 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176280007153 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 176280007154 Cna protein B-type domain; Region: Cna_B; pfam05738 176280007155 Cna protein B-type domain; Region: Cna_B; pfam05738 176280007156 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 176280007157 Cna protein B-type domain; Region: Cna_B; pfam05738 176280007158 benzoate transport; Region: 2A0115; TIGR00895 176280007159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280007160 putative substrate translocation pore; other site 176280007161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280007162 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 176280007163 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 176280007164 Catalytic site [active] 176280007165 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 176280007166 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176280007167 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176280007168 Walker A/P-loop; other site 176280007169 ATP binding site [chemical binding]; other site 176280007170 Q-loop/lid; other site 176280007171 ABC transporter signature motif; other site 176280007172 Walker B; other site 176280007173 D-loop; other site 176280007174 H-loop/switch region; other site 176280007175 FtsX-like permease family; Region: FtsX; pfam02687 176280007176 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 176280007177 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 176280007178 FtsX-like permease family; Region: FtsX; pfam02687 176280007179 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176280007180 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176280007181 Walker A/P-loop; other site 176280007182 ATP binding site [chemical binding]; other site 176280007183 Q-loop/lid; other site 176280007184 ABC transporter signature motif; other site 176280007185 Walker B; other site 176280007186 D-loop; other site 176280007187 H-loop/switch region; other site 176280007188 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 176280007189 HlyD family secretion protein; Region: HlyD_3; pfam13437 176280007190 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 176280007191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176280007192 non-specific DNA binding site [nucleotide binding]; other site 176280007193 salt bridge; other site 176280007194 sequence-specific DNA binding site [nucleotide binding]; other site 176280007195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 176280007196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176280007197 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 176280007198 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 176280007199 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 176280007200 ParB-like nuclease domain; Region: ParBc; pfam02195 176280007201 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 176280007202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176280007203 S-adenosylmethionine binding site [chemical binding]; other site 176280007204 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 176280007205 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 176280007206 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 176280007207 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 176280007208 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 176280007209 trmE is a tRNA modification GTPase; Region: trmE; cd04164 176280007210 G1 box; other site 176280007211 GTP/Mg2+ binding site [chemical binding]; other site 176280007212 Switch I region; other site 176280007213 G2 box; other site 176280007214 Switch II region; other site 176280007215 G3 box; other site 176280007216 G4 box; other site 176280007217 G5 box; other site 176280007218 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 176280007219 ribonuclease P; Reviewed; Region: rnpA; PRK00499 176280007220 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 176280007221 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 176280007222 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 176280007223 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 176280007224 Predicted membrane protein [Function unknown]; Region: COG3462 176280007225 Initiator Replication protein; Region: Rep_3; pfam01051 176280007226 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 176280007227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176280007228 non-specific DNA binding site [nucleotide binding]; other site 176280007229 salt bridge; other site 176280007230 sequence-specific DNA binding site [nucleotide binding]; other site 176280007231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 176280007232 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 176280007233 active site 176280007234 ATP binding site [chemical binding]; other site 176280007235 substrate binding site [chemical binding]; other site 176280007236 activation loop (A-loop); other site 176280007237 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 176280007238 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 176280007239 active site 176280007240 zinc binding site [ion binding]; other site 176280007241 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 176280007242 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 176280007243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176280007244 Walker A/P-loop; other site 176280007245 ATP binding site [chemical binding]; other site 176280007246 Q-loop/lid; other site 176280007247 ABC transporter signature motif; other site 176280007248 Walker B; other site 176280007249 D-loop; other site 176280007250 H-loop/switch region; other site 176280007251 Predicted transcriptional regulators [Transcription]; Region: COG1695 176280007252 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 176280007253 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 176280007254 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176280007255 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176280007256 catalytic residues [active] 176280007257 catalytic nucleophile [active] 176280007258 Presynaptic Site I dimer interface [polypeptide binding]; other site 176280007259 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176280007260 Synaptic Flat tetramer interface [polypeptide binding]; other site 176280007261 Synaptic Site I dimer interface [polypeptide binding]; other site 176280007262 DNA binding site [nucleotide binding] 176280007263 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 176280007264 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 176280007265 Predicted transcriptional regulator [Transcription]; Region: COG3682 176280007266 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176280007267 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176280007268 Presynaptic Site I dimer interface [polypeptide binding]; other site 176280007269 catalytic residues [active] 176280007270 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176280007271 Synaptic Flat tetramer interface [polypeptide binding]; other site 176280007272 Synaptic Site I dimer interface [polypeptide binding]; other site 176280007273 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 176280007274 DNA-binding interface [nucleotide binding]; DNA binding site 176280007275 Helix-turn-helix domain; Region: HTH_28; pfam13518 176280007276 Winged helix-turn helix; Region: HTH_29; pfam13551 176280007277 Homeodomain-like domain; Region: HTH_32; pfam13565 176280007278 Integrase core domain; Region: rve; pfam00665 176280007279 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 176280007280 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 176280007281 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 176280007282 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 176280007283 dimer interface [polypeptide binding]; other site 176280007284 active site 176280007285 CoA binding pocket [chemical binding]; other site 176280007286 GPI transamidase subunit PIG-U; Region: PIG-U; pfam06728 176280007287 HTH domain; Region: HTH_11; cl17392 176280007288 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 176280007289 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 176280007290 Divergent AAA domain; Region: AAA_4; pfam04326 176280007291 MobA/MobL family; Region: MobA_MobL; pfam03389 176280007292 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 176280007293 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 176280007294 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 176280007295 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 176280007296 Uncharacterized conserved protein [Function unknown]; Region: COG1284 176280007297 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 176280007298 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 176280007299 multiple promoter invertase; Provisional; Region: mpi; PRK13413 176280007300 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176280007301 catalytic residues [active] 176280007302 catalytic nucleophile [active] 176280007303 Presynaptic Site I dimer interface [polypeptide binding]; other site 176280007304 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176280007305 Synaptic Flat tetramer interface [polypeptide binding]; other site 176280007306 Synaptic Site I dimer interface [polypeptide binding]; other site 176280007307 DNA binding site [nucleotide binding] 176280007308 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 176280007309 DNA-binding interface [nucleotide binding]; DNA binding site 176280007310 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176280007311 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176280007312 Presynaptic Site I dimer interface [polypeptide binding]; other site 176280007313 catalytic residues [active] 176280007314 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176280007315 Synaptic Flat tetramer interface [polypeptide binding]; other site 176280007316 Synaptic Site I dimer interface [polypeptide binding]; other site 176280007317 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 176280007318 DNA-binding interface [nucleotide binding]; DNA binding site 176280007319 multiple promoter invertase; Provisional; Region: mpi; PRK13413 176280007320 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176280007321 catalytic residues [active] 176280007322 catalytic nucleophile [active] 176280007323 Presynaptic Site I dimer interface [polypeptide binding]; other site 176280007324 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176280007325 Synaptic Flat tetramer interface [polypeptide binding]; other site 176280007326 Synaptic Site I dimer interface [polypeptide binding]; other site 176280007327 DNA binding site [nucleotide binding] 176280007328 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 176280007329 DNA-binding interface [nucleotide binding]; DNA binding site 176280007330 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 176280007331 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 176280007332 Sulfate transporter family; Region: Sulfate_transp; pfam00916 176280007333 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 176280007334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 176280007335 Ligand Binding Site [chemical binding]; other site 176280007336 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 176280007337 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176280007338 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176280007339 catalytic residues [active] 176280007340 catalytic nucleophile [active] 176280007341 Presynaptic Site I dimer interface [polypeptide binding]; other site 176280007342 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176280007343 Synaptic Flat tetramer interface [polypeptide binding]; other site 176280007344 Synaptic Site I dimer interface [polypeptide binding]; other site 176280007345 DNA binding site [nucleotide binding] 176280007346 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 176280007347 DNA-binding interface [nucleotide binding]; DNA binding site 176280007348 DNA polymerase; Provisional; Region: PHA02563 176280007349 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176280007350 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176280007351 catalytic residues [active] 176280007352 catalytic nucleophile [active] 176280007353 Presynaptic Site I dimer interface [polypeptide binding]; other site 176280007354 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176280007355 Synaptic Flat tetramer interface [polypeptide binding]; other site 176280007356 Synaptic Site I dimer interface [polypeptide binding]; other site 176280007357 DNA binding site [nucleotide binding] 176280007358 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 176280007359 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 176280007360 Helix-turn-helix domain; Region: HTH_17; cl17695 176280007361 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 176280007362 Replication initiation factor; Region: Rep_trans; pfam02486 176280007363 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 176280007364 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 176280007365 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 176280007366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176280007367 putative substrate translocation pore; other site 176280007368 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 176280007369 Replication initiation factor; Region: Rep_trans; pfam02486