-- dump date 20140620_075923 -- class Genbank::misc_feature -- table misc_feature_note -- id note 279808000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 279808000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 279808000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808000004 Walker A motif; other site 279808000005 ATP binding site [chemical binding]; other site 279808000006 Walker B motif; other site 279808000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 279808000008 arginine finger; other site 279808000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 279808000010 DnaA box-binding interface [nucleotide binding]; other site 279808000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 279808000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 279808000013 putative DNA binding surface [nucleotide binding]; other site 279808000014 dimer interface [polypeptide binding]; other site 279808000015 beta-clamp/clamp loader binding surface; other site 279808000016 beta-clamp/translesion DNA polymerase binding surface; other site 279808000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 279808000018 recombination protein F; Reviewed; Region: recF; PRK00064 279808000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 279808000020 Walker A/P-loop; other site 279808000021 ATP binding site [chemical binding]; other site 279808000022 Q-loop/lid; other site 279808000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000024 ABC transporter signature motif; other site 279808000025 Walker B; other site 279808000026 D-loop; other site 279808000027 H-loop/switch region; other site 279808000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 279808000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808000030 Mg2+ binding site [ion binding]; other site 279808000031 G-X-G motif; other site 279808000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 279808000033 anchoring element; other site 279808000034 dimer interface [polypeptide binding]; other site 279808000035 ATP binding site [chemical binding]; other site 279808000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 279808000037 active site 279808000038 putative metal-binding site [ion binding]; other site 279808000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 279808000040 DNA gyrase subunit A; Validated; Region: PRK05560 279808000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 279808000042 CAP-like domain; other site 279808000043 active site 279808000044 primary dimer interface [polypeptide binding]; other site 279808000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279808000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279808000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279808000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279808000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279808000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279808000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 279808000052 putative substrate binding site [chemical binding]; other site 279808000053 putative ATP binding site [chemical binding]; other site 279808000054 seryl-tRNA synthetase; Provisional; Region: PRK05431 279808000055 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 279808000056 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 279808000057 dimer interface [polypeptide binding]; other site 279808000058 active site 279808000059 motif 1; other site 279808000060 motif 2; other site 279808000061 motif 3; other site 279808000062 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 279808000063 Predicted membrane protein [Function unknown]; Region: COG4392 279808000064 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 279808000065 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 279808000066 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 279808000067 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 279808000068 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 279808000069 DHH family; Region: DHH; pfam01368 279808000070 DHHA1 domain; Region: DHHA1; pfam02272 279808000071 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 279808000072 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 279808000073 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 279808000074 replicative DNA helicase; Region: DnaB; TIGR00665 279808000075 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 279808000076 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 279808000077 Walker A motif; other site 279808000078 ATP binding site [chemical binding]; other site 279808000079 Walker B motif; other site 279808000080 DNA binding loops [nucleotide binding] 279808000081 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 279808000082 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 279808000083 GDP-binding site [chemical binding]; other site 279808000084 ACT binding site; other site 279808000085 IMP binding site; other site 279808000086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808000087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808000088 active site 279808000089 phosphorylation site [posttranslational modification] 279808000090 intermolecular recognition site; other site 279808000091 dimerization interface [polypeptide binding]; other site 279808000092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279808000093 DNA binding site [nucleotide binding] 279808000094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 279808000095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279808000096 dimerization interface [polypeptide binding]; other site 279808000097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 279808000098 putative active site [active] 279808000099 heme pocket [chemical binding]; other site 279808000100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279808000101 dimer interface [polypeptide binding]; other site 279808000102 phosphorylation site [posttranslational modification] 279808000103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808000104 ATP binding site [chemical binding]; other site 279808000105 Mg2+ binding site [ion binding]; other site 279808000106 G-X-G motif; other site 279808000107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 279808000108 YycH protein; Region: YycH; pfam07435 279808000109 YycH protein; Region: YycI; cl02015 279808000110 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 279808000111 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 279808000112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808000113 Integrase core domain; Region: rve; pfam00665 279808000114 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 279808000115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808000116 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808000117 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808000118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808000119 active site 279808000120 phosphorylation site [posttranslational modification] 279808000121 intermolecular recognition site; other site 279808000122 dimerization interface [polypeptide binding]; other site 279808000123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279808000124 DNA binding site [nucleotide binding] 279808000125 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 279808000126 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 279808000127 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 279808000128 Ligand Binding Site [chemical binding]; other site 279808000129 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 279808000130 GAF domain; Region: GAF; cl17456 279808000131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279808000132 dimer interface [polypeptide binding]; other site 279808000133 phosphorylation site [posttranslational modification] 279808000134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808000135 ATP binding site [chemical binding]; other site 279808000136 Mg2+ binding site [ion binding]; other site 279808000137 G-X-G motif; other site 279808000138 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 279808000139 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 279808000140 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279808000141 Soluble P-type ATPase [General function prediction only]; Region: COG4087 279808000142 potassium-transporting ATPase subunit C; Provisional; Region: PRK14000 279808000143 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 279808000144 MARCKS family; Region: MARCKS; pfam02063 279808000145 Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466 279808000146 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 279808000147 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 279808000148 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 279808000149 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 279808000150 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 279808000151 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279808000152 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 279808000153 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 279808000154 FMN binding site [chemical binding]; other site 279808000155 substrate binding site [chemical binding]; other site 279808000156 putative catalytic residue [active] 279808000157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279808000158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279808000159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 279808000160 dimerization interface [polypeptide binding]; other site 279808000161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000162 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279808000163 putative substrate translocation pore; other site 279808000164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808000165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808000166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808000167 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 279808000168 dimer interface [polypeptide binding]; other site 279808000169 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279808000170 Predicted transcriptional regulator [Transcription]; Region: COG2378 279808000171 HTH domain; Region: HTH_11; pfam08279 279808000172 WYL domain; Region: WYL; pfam13280 279808000173 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 279808000174 active site 279808000175 DNA binding site [nucleotide binding] 279808000176 catalytic site [active] 279808000177 Phage associated DNA primase [General function prediction only]; Region: COG3378 279808000178 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279808000179 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 279808000180 catalytic residues [active] 279808000181 catalytic nucleophile [active] 279808000182 Recombinase; Region: Recombinase; pfam07508 279808000183 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 279808000184 FlxA-like protein; Region: FlxA; pfam14282 279808000185 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 279808000186 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 279808000187 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 279808000188 Lysis protein; Region: Lysis_col; pfam02402 279808000189 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 279808000190 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 279808000191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279808000192 ATP binding site [chemical binding]; other site 279808000193 putative Mg++ binding site [ion binding]; other site 279808000194 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 279808000195 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279808000196 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 279808000197 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 279808000198 HsdM N-terminal domain; Region: HsdM_N; pfam12161 279808000199 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 279808000200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808000201 S-adenosylmethionine binding site [chemical binding]; other site 279808000202 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 279808000203 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 279808000204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808000205 catalytic residue [active] 279808000206 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 279808000207 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 279808000208 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 279808000209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000210 putative substrate translocation pore; other site 279808000211 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 279808000212 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 279808000213 Ca binding site [ion binding]; other site 279808000214 active site 279808000215 catalytic site [active] 279808000216 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 279808000217 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279808000218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279808000219 DNA binding site [nucleotide binding] 279808000220 domain linker motif; other site 279808000221 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 279808000222 dimerization interface [polypeptide binding]; other site 279808000223 ligand binding site [chemical binding]; other site 279808000224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279808000225 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279808000226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279808000227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808000228 Integrase core domain; Region: rve; pfam00665 279808000229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808000230 Integrase core domain; Region: rve; pfam00665 279808000231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808000232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808000233 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 279808000234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000235 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808000236 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808000237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000238 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279808000239 Q-loop/lid; other site 279808000240 ABC transporter signature motif; other site 279808000241 Walker B; other site 279808000242 D-loop; other site 279808000243 H-loop/switch region; other site 279808000244 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 279808000245 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 279808000246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808000247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808000248 Protein of unknown function (DUF524); Region: DUF524; pfam04411 279808000249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 279808000250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808000251 Integrase core domain; Region: rve; pfam00665 279808000252 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 279808000253 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279808000254 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 279808000255 putative active site [active] 279808000256 catalytic site [active] 279808000257 putative metal binding site [ion binding]; other site 279808000258 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 279808000259 putative active site [active] 279808000260 putative catalytic site [active] 279808000261 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 279808000262 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279808000263 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279808000264 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279808000265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808000266 Integrase core domain; Region: rve; pfam00665 279808000267 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 279808000268 DNA binding residues [nucleotide binding] 279808000269 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279808000270 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 279808000271 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 279808000272 potential catalytic triad [active] 279808000273 conserved cys residue [active] 279808000274 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 279808000275 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279808000276 NAD(P) binding site [chemical binding]; other site 279808000277 putative active site [active] 279808000278 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 279808000279 Prostaglandin dehydrogenases; Region: PGDH; cd05288 279808000280 NAD(P) binding site [chemical binding]; other site 279808000281 substrate binding site [chemical binding]; other site 279808000282 dimer interface [polypeptide binding]; other site 279808000283 Predicted membrane protein [Function unknown]; Region: COG4270 279808000284 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 279808000285 Cadmium resistance transporter; Region: Cad; pfam03596 279808000286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279808000287 putative DNA binding site [nucleotide binding]; other site 279808000288 putative Zn2+ binding site [ion binding]; other site 279808000289 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279808000290 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 279808000291 active site 279808000292 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 279808000293 arsenical pump membrane protein; Provisional; Region: PRK15445 279808000294 transmembrane helices; other site 279808000295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279808000296 dimerization interface [polypeptide binding]; other site 279808000297 putative DNA binding site [nucleotide binding]; other site 279808000298 putative Zn2+ binding site [ion binding]; other site 279808000299 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 279808000300 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 279808000301 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279808000302 Soluble P-type ATPase [General function prediction only]; Region: COG4087 279808000303 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 279808000304 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 279808000305 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 279808000306 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 279808000307 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 279808000308 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279808000309 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 279808000310 active site 279808000311 arsenical pump membrane protein; Provisional; Region: PRK15445 279808000312 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 279808000313 transmembrane helices; other site 279808000314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279808000315 dimerization interface [polypeptide binding]; other site 279808000316 putative DNA binding site [nucleotide binding]; other site 279808000317 putative Zn2+ binding site [ion binding]; other site 279808000318 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 279808000319 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 279808000320 P loop; other site 279808000321 Nucleotide binding site [chemical binding]; other site 279808000322 DTAP/Switch II; other site 279808000323 Switch I; other site 279808000324 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 279808000325 P loop; other site 279808000326 Nucleotide binding site [chemical binding]; other site 279808000327 DTAP/Switch II; other site 279808000328 Switch I; other site 279808000329 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 279808000330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279808000331 dimerization interface [polypeptide binding]; other site 279808000332 putative DNA binding site [nucleotide binding]; other site 279808000333 putative Zn2+ binding site [ion binding]; other site 279808000334 Predicted permeases [General function prediction only]; Region: COG0701 279808000335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 279808000336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808000337 Coenzyme A binding pocket [chemical binding]; other site 279808000338 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 279808000339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808000340 Integrase core domain; Region: rve; pfam00665 279808000341 Protein of unknown function, DUF576; Region: DUF576; cl04553 279808000342 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 279808000343 Mechanosensitive ion channel; Region: MS_channel; pfam00924 279808000344 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 279808000345 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 279808000346 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 279808000347 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 279808000348 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279808000349 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 279808000350 intersubunit interface [polypeptide binding]; other site 279808000351 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 279808000352 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 279808000353 TfoX N-terminal domain; Region: TfoX_N; cl17592 279808000354 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 279808000355 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 279808000356 metal binding site [ion binding]; metal-binding site 279808000357 dimer interface [polypeptide binding]; other site 279808000358 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 279808000359 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 279808000360 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 279808000361 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 279808000362 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 279808000363 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 279808000364 active site 279808000365 dimer interface [polypeptide binding]; other site 279808000366 motif 1; other site 279808000367 motif 2; other site 279808000368 motif 3; other site 279808000369 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 279808000370 anticodon binding site; other site 279808000371 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279808000372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000373 Walker A/P-loop; other site 279808000374 ATP binding site [chemical binding]; other site 279808000375 Q-loop/lid; other site 279808000376 ABC transporter signature motif; other site 279808000377 Walker B; other site 279808000378 D-loop; other site 279808000379 H-loop/switch region; other site 279808000380 MepB protein; Region: MepB; pfam08877 279808000381 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 279808000382 Acyltransferase family; Region: Acyl_transf_3; pfam01757 279808000383 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279808000384 active site 279808000385 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 279808000386 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 279808000387 metal binding site [ion binding]; metal-binding site 279808000388 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 279808000389 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279808000390 ABC-ATPase subunit interface; other site 279808000391 dimer interface [polypeptide binding]; other site 279808000392 putative PBP binding regions; other site 279808000393 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 279808000394 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 279808000395 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 279808000396 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 279808000397 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 279808000398 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 279808000399 Methyltransferase domain; Region: Methyltransf_23; pfam13489 279808000400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808000401 S-adenosylmethionine binding site [chemical binding]; other site 279808000402 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 279808000403 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 279808000404 substrate binding site [chemical binding]; other site 279808000405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279808000406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808000407 dimer interface [polypeptide binding]; other site 279808000408 conserved gate region; other site 279808000409 putative PBP binding loops; other site 279808000410 ABC-ATPase subunit interface; other site 279808000411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 279808000412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 279808000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808000414 dimer interface [polypeptide binding]; other site 279808000415 conserved gate region; other site 279808000416 putative PBP binding loops; other site 279808000417 ABC-ATPase subunit interface; other site 279808000418 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 279808000419 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279808000420 Walker A/P-loop; other site 279808000421 ATP binding site [chemical binding]; other site 279808000422 Q-loop/lid; other site 279808000423 ABC transporter signature motif; other site 279808000424 Walker B; other site 279808000425 D-loop; other site 279808000426 H-loop/switch region; other site 279808000427 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 279808000428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000429 Walker A/P-loop; other site 279808000430 ATP binding site [chemical binding]; other site 279808000431 Q-loop/lid; other site 279808000432 ABC transporter signature motif; other site 279808000433 Walker B; other site 279808000434 D-loop; other site 279808000435 H-loop/switch region; other site 279808000436 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279808000437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000438 putative substrate translocation pore; other site 279808000439 Patatin-like phospholipase; Region: Patatin; pfam01734 279808000440 active site 279808000441 nucleophile elbow; other site 279808000442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279808000443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000445 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279808000446 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 279808000447 DNA binding residues [nucleotide binding] 279808000448 putative dimer interface [polypeptide binding]; other site 279808000449 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 279808000450 active site 279808000451 Domain of unknown function DUF21; Region: DUF21; pfam01595 279808000452 FOG: CBS domain [General function prediction only]; Region: COG0517 279808000453 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279808000454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808000455 active site 279808000456 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 279808000457 RibD C-terminal domain; Region: RibD_C; cl17279 279808000458 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 279808000459 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 279808000460 FtsX-like permease family; Region: FtsX; pfam02687 279808000461 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279808000462 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279808000463 Walker A/P-loop; other site 279808000464 ATP binding site [chemical binding]; other site 279808000465 Q-loop/lid; other site 279808000466 ABC transporter signature motif; other site 279808000467 Walker B; other site 279808000468 D-loop; other site 279808000469 H-loop/switch region; other site 279808000470 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 279808000471 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 279808000472 dimer interface [polypeptide binding]; other site 279808000473 FMN binding site [chemical binding]; other site 279808000474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 279808000475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279808000476 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 279808000477 active site 279808000478 metal binding site [ion binding]; metal-binding site 279808000479 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 279808000480 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 279808000481 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 279808000482 Predicted transcriptional regulator [Transcription]; Region: COG2378 279808000483 WYL domain; Region: WYL; pfam13280 279808000484 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279808000485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279808000486 DNA binding site [nucleotide binding] 279808000487 domain linker motif; other site 279808000488 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 279808000489 dimerization interface [polypeptide binding]; other site 279808000490 ligand binding site [chemical binding]; other site 279808000491 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 279808000492 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279808000493 substrate binding site [chemical binding]; other site 279808000494 dimer interface [polypeptide binding]; other site 279808000495 ATP binding site [chemical binding]; other site 279808000496 D-ribose pyranase; Provisional; Region: PRK11797 279808000497 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 279808000498 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 279808000499 Walker A/P-loop; other site 279808000500 ATP binding site [chemical binding]; other site 279808000501 Q-loop/lid; other site 279808000502 ABC transporter signature motif; other site 279808000503 Walker B; other site 279808000504 D-loop; other site 279808000505 H-loop/switch region; other site 279808000506 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 279808000507 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 279808000508 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 279808000509 TM-ABC transporter signature motif; other site 279808000510 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 279808000511 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 279808000512 ligand binding site [chemical binding]; other site 279808000513 dimerization interface [polypeptide binding]; other site 279808000514 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 279808000515 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 279808000516 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 279808000517 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 279808000518 oligomerization interface [polypeptide binding]; other site 279808000519 active site 279808000520 metal binding site [ion binding]; metal-binding site 279808000521 pantoate--beta-alanine ligase; Region: panC; TIGR00018 279808000522 Pantoate-beta-alanine ligase; Region: PanC; cd00560 279808000523 active site 279808000524 ATP-binding site [chemical binding]; other site 279808000525 pantoate-binding site; other site 279808000526 HXXH motif; other site 279808000527 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 279808000528 tetramerization interface [polypeptide binding]; other site 279808000529 active site 279808000530 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 279808000531 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 279808000532 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279808000533 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279808000534 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279808000535 putative active site [active] 279808000536 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 279808000537 active site 279808000538 P-loop; other site 279808000539 phosphorylation site [posttranslational modification] 279808000540 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 279808000541 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 279808000542 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 279808000543 active site 279808000544 methionine cluster; other site 279808000545 phosphorylation site [posttranslational modification] 279808000546 metal binding site [ion binding]; metal-binding site 279808000547 Uncharacterized conserved protein [Function unknown]; Region: COG3589 279808000548 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 279808000549 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 279808000550 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279808000551 nucleotide binding site [chemical binding]; other site 279808000552 Uncharacterized protein conserved in archaea (DUF2115); Region: DUF2115; cl01681 279808000553 Predicted membrane protein [Function unknown]; Region: COG3152 279808000554 Predicted membrane protein [Function unknown]; Region: COG2311 279808000555 Protein of unknown function (DUF418); Region: DUF418; pfam04235 279808000556 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 279808000557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000558 Walker A/P-loop; other site 279808000559 ATP binding site [chemical binding]; other site 279808000560 Q-loop/lid; other site 279808000561 ABC transporter signature motif; other site 279808000562 Walker B; other site 279808000563 D-loop; other site 279808000564 H-loop/switch region; other site 279808000565 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 279808000566 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 279808000567 arsenical pump membrane protein; Provisional; Region: PRK15445 279808000568 transmembrane helices; other site 279808000569 Predicted membrane protein [Function unknown]; Region: COG1288 279808000570 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 279808000571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808000572 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808000573 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808000574 metal-dependent hydrolase; Provisional; Region: PRK13291 279808000575 DinB superfamily; Region: DinB_2; pfam12867 279808000576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808000577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808000578 active site 279808000579 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 279808000580 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 279808000581 putative N- and C-terminal domain interface [polypeptide binding]; other site 279808000582 putative active site [active] 279808000583 MgATP binding site [chemical binding]; other site 279808000584 catalytic site [active] 279808000585 metal binding site [ion binding]; metal-binding site 279808000586 putative carbohydrate binding site [chemical binding]; other site 279808000587 polyol permease family; Region: 2A0118; TIGR00897 279808000588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000589 putative substrate translocation pore; other site 279808000590 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 279808000591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808000592 NAD(P) binding site [chemical binding]; other site 279808000593 active site 279808000594 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 279808000595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000596 Walker A/P-loop; other site 279808000597 ATP binding site [chemical binding]; other site 279808000598 Q-loop/lid; other site 279808000599 ABC transporter signature motif; other site 279808000600 Walker B; other site 279808000601 D-loop; other site 279808000602 H-loop/switch region; other site 279808000603 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 279808000604 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 279808000605 succinic semialdehyde dehydrogenase; Region: PLN02278 279808000606 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 279808000607 tetramerization interface [polypeptide binding]; other site 279808000608 NAD(P) binding site [chemical binding]; other site 279808000609 catalytic residues [active] 279808000610 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 279808000611 L-idonate 5-dehydrogenase; Region: PLN02702 279808000612 inhibitor binding site; inhibition site 279808000613 catalytic Zn binding site [ion binding]; other site 279808000614 structural Zn binding site [ion binding]; other site 279808000615 NADP binding site [chemical binding]; other site 279808000616 tetramer interface [polypeptide binding]; other site 279808000617 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808000618 MarR family; Region: MarR; pfam01047 279808000619 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 279808000620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808000621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808000622 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279808000623 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 279808000624 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 279808000625 potential catalytic triad [active] 279808000626 conserved cys residue [active] 279808000627 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 279808000628 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 279808000629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279808000630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808000631 homodimer interface [polypeptide binding]; other site 279808000632 catalytic residue [active] 279808000633 Uncharacterized conserved protein [Function unknown]; Region: COG2128 279808000634 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 279808000635 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808000636 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808000637 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279808000638 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 279808000639 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 279808000640 tetramer interface [polypeptide binding]; other site 279808000641 TPP-binding site [chemical binding]; other site 279808000642 heterodimer interface [polypeptide binding]; other site 279808000643 phosphorylation loop region [posttranslational modification] 279808000644 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 279808000645 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 279808000646 alpha subunit interface [polypeptide binding]; other site 279808000647 TPP binding site [chemical binding]; other site 279808000648 heterodimer interface [polypeptide binding]; other site 279808000649 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279808000650 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 279808000651 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279808000652 E3 interaction surface; other site 279808000653 lipoyl attachment site [posttranslational modification]; other site 279808000654 e3 binding domain; Region: E3_binding; pfam02817 279808000655 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 279808000656 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 279808000657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808000658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808000659 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279808000660 Predicted transcriptional regulators [Transcription]; Region: COG1695 279808000661 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 279808000662 hypothetical protein; Validated; Region: PRK07668 279808000663 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 279808000664 classical (c) SDRs; Region: SDR_c; cd05233 279808000665 NAD(P) binding site [chemical binding]; other site 279808000666 active site 279808000667 Protein of unknown function DUF262; Region: DUF262; pfam03235 279808000668 Uncharacterized conserved protein [Function unknown]; Region: COG1479 279808000669 Protein of unknown function DUF262; Region: DUF262; pfam03235 279808000670 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 279808000671 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 279808000672 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 279808000673 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 279808000674 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279808000675 active site 279808000676 phosphorylation site [posttranslational modification] 279808000677 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 279808000678 HTH domain; Region: HTH_11; pfam08279 279808000679 PRD domain; Region: PRD; pfam00874 279808000680 PRD domain; Region: PRD; pfam00874 279808000681 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 279808000682 active site 279808000683 P-loop; other site 279808000684 phosphorylation site [posttranslational modification] 279808000685 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 279808000686 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 279808000687 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 279808000688 active site 279808000689 P-loop; other site 279808000690 phosphorylation site [posttranslational modification] 279808000691 Predicted permeases [General function prediction only]; Region: RarD; COG2962 279808000692 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 279808000693 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279808000694 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 279808000695 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279808000696 Integral membrane protein DUF95; Region: DUF95; pfam01944 279808000697 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 279808000698 GIY-YIG motif/motif A; other site 279808000699 putative active site [active] 279808000700 putative metal binding site [ion binding]; other site 279808000701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 279808000702 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 279808000703 Walker A motif; other site 279808000704 ATP binding site [chemical binding]; other site 279808000705 Walker B motif; other site 279808000706 Uncharacterized conserved protein [Function unknown]; Region: COG3410 279808000707 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 279808000708 homodimer interface [polypeptide binding]; other site 279808000709 chemical substrate binding site [chemical binding]; other site 279808000710 oligomer interface [polypeptide binding]; other site 279808000711 metal binding site [ion binding]; metal-binding site 279808000712 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 279808000713 Double zinc ribbon; Region: DZR; pfam12773 279808000714 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 279808000715 NMT1/THI5 like; Region: NMT1; pfam09084 279808000716 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808000717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808000718 non-specific DNA binding site [nucleotide binding]; other site 279808000719 salt bridge; other site 279808000720 sequence-specific DNA binding site [nucleotide binding]; other site 279808000721 CAAX protease self-immunity; Region: Abi; pfam02517 279808000722 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 279808000723 DNA binding residues [nucleotide binding] 279808000724 dimer interface [polypeptide binding]; other site 279808000725 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 279808000726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808000727 non-specific DNA binding site [nucleotide binding]; other site 279808000728 salt bridge; other site 279808000729 sequence-specific DNA binding site [nucleotide binding]; other site 279808000730 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 279808000731 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 279808000732 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 279808000733 ornithine carbamoyltransferase; Provisional; Region: PRK04284 279808000734 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 279808000735 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 279808000736 carbamate kinase; Reviewed; Region: PRK12686 279808000737 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 279808000738 putative substrate binding site [chemical binding]; other site 279808000739 nucleotide binding site [chemical binding]; other site 279808000740 nucleotide binding site [chemical binding]; other site 279808000741 homodimer interface [polypeptide binding]; other site 279808000742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808000743 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808000744 sequence-specific DNA binding site [nucleotide binding]; other site 279808000745 salt bridge; other site 279808000746 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 279808000747 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 279808000748 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 279808000749 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 279808000750 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 279808000751 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 279808000752 putative ADP-ribose binding site [chemical binding]; other site 279808000753 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 279808000754 lipoyl attachment site [posttranslational modification]; other site 279808000755 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 279808000756 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 279808000757 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 279808000758 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 279808000759 putative active site [active] 279808000760 putative FMN binding site [chemical binding]; other site 279808000761 putative substrate binding site [chemical binding]; other site 279808000762 putative catalytic residue [active] 279808000763 biotin synthase; Validated; Region: PRK06256 279808000764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279808000765 FeS/SAM binding site; other site 279808000766 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 279808000767 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 279808000768 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 279808000769 transmembrane helices; other site 279808000770 Predicted integral membrane protein [Function unknown]; Region: COG5505 279808000771 hypothetical protein; Provisional; Region: PRK05463 279808000772 BCCT family transporter; Region: BCCT; pfam02028 279808000773 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 279808000774 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 279808000775 active site 279808000776 dimer interface [polypeptide binding]; other site 279808000777 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 279808000778 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 279808000779 active site 279808000780 trimer interface [polypeptide binding]; other site 279808000781 allosteric site; other site 279808000782 active site lid [active] 279808000783 hexamer (dimer of trimers) interface [polypeptide binding]; other site 279808000784 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 279808000785 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 279808000786 putative active site cavity [active] 279808000787 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279808000788 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279808000789 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279808000790 putative active site [active] 279808000791 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 279808000792 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279808000793 nucleotide binding site [chemical binding]; other site 279808000794 N-acetylneuraminate lyase; Provisional; Region: PRK04147 279808000795 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 279808000796 inhibitor site; inhibition site 279808000797 active site 279808000798 dimer interface [polypeptide binding]; other site 279808000799 catalytic residue [active] 279808000800 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 279808000801 putative transporter; Provisional; Region: PRK10484 279808000802 Na binding site [ion binding]; other site 279808000803 CAAX protease self-immunity; Region: Abi; pfam02517 279808000804 CAAX protease self-immunity; Region: Abi; pfam02517 279808000805 CAAX protease self-immunity; Region: Abi; pfam02517 279808000806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279808000807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000808 Walker A/P-loop; other site 279808000809 ATP binding site [chemical binding]; other site 279808000810 Q-loop/lid; other site 279808000811 ABC transporter signature motif; other site 279808000812 Walker B; other site 279808000813 D-loop; other site 279808000814 H-loop/switch region; other site 279808000815 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 279808000816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279808000817 Walker A/P-loop; other site 279808000818 ATP binding site [chemical binding]; other site 279808000819 Q-loop/lid; other site 279808000820 ABC transporter signature motif; other site 279808000821 Walker B; other site 279808000822 D-loop; other site 279808000823 H-loop/switch region; other site 279808000824 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 279808000825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808000826 dimer interface [polypeptide binding]; other site 279808000827 conserved gate region; other site 279808000828 putative PBP binding loops; other site 279808000829 ABC-ATPase subunit interface; other site 279808000830 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279808000831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808000832 dimer interface [polypeptide binding]; other site 279808000833 conserved gate region; other site 279808000834 putative PBP binding loops; other site 279808000835 ABC-ATPase subunit interface; other site 279808000836 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 279808000837 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 279808000838 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 279808000839 putative substrate binding pocket [chemical binding]; other site 279808000840 AC domain interface; other site 279808000841 catalytic triad [active] 279808000842 AB domain interface; other site 279808000843 interchain disulfide; other site 279808000844 Predicted membrane protein [Function unknown]; Region: COG3817 279808000845 Protein of unknown function (DUF979); Region: DUF979; pfam06166 279808000846 Protein of unknown function (DUF969); Region: DUF969; pfam06149 279808000847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279808000848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000849 putative substrate translocation pore; other site 279808000850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000851 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 279808000852 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 279808000853 active site 279808000854 H+ Antiporter protein; Region: 2A0121; TIGR00900 279808000855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000856 putative substrate translocation pore; other site 279808000857 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 279808000858 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 279808000859 active site residue [active] 279808000860 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 279808000861 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 279808000862 Strictosidine synthase; Region: Str_synth; pfam03088 279808000863 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 279808000864 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 279808000865 active site 279808000866 substrate binding site [chemical binding]; other site 279808000867 metal binding site [ion binding]; metal-binding site 279808000868 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 279808000869 putative active site [active] 279808000870 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 279808000871 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 279808000872 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 279808000873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808000874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808000875 myosin-cross-reactive antigen; Provisional; Region: PRK13977 279808000876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000877 Walker A/P-loop; other site 279808000878 ATP binding site [chemical binding]; other site 279808000879 Q-loop/lid; other site 279808000880 AAA domain; Region: AAA_21; pfam13304 279808000881 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 279808000882 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 279808000883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808000884 Walker A/P-loop; other site 279808000885 ATP binding site [chemical binding]; other site 279808000886 Q-loop/lid; other site 279808000887 ABC transporter signature motif; other site 279808000888 Walker B; other site 279808000889 D-loop; other site 279808000890 H-loop/switch region; other site 279808000891 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 279808000892 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 279808000893 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 279808000894 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279808000895 Walker A/P-loop; other site 279808000896 ATP binding site [chemical binding]; other site 279808000897 Q-loop/lid; other site 279808000898 ABC transporter signature motif; other site 279808000899 Walker B; other site 279808000900 D-loop; other site 279808000901 H-loop/switch region; other site 279808000902 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 279808000903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808000904 non-specific DNA binding site [nucleotide binding]; other site 279808000905 salt bridge; other site 279808000906 sequence-specific DNA binding site [nucleotide binding]; other site 279808000907 Predicted transcriptional regulator [Transcription]; Region: COG1959 279808000908 Transcriptional regulator; Region: Rrf2; pfam02082 279808000909 EamA-like transporter family; Region: EamA; pfam00892 279808000910 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 279808000911 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279808000912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000913 putative substrate translocation pore; other site 279808000914 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 279808000915 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 279808000916 active site 279808000917 metal binding site [ion binding]; metal-binding site 279808000918 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279808000919 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 279808000920 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279808000921 membrane-bound complex binding site; other site 279808000922 hinge residues; other site 279808000923 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 279808000924 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 279808000925 Walker A/P-loop; other site 279808000926 ATP binding site [chemical binding]; other site 279808000927 Q-loop/lid; other site 279808000928 ABC transporter signature motif; other site 279808000929 Walker B; other site 279808000930 D-loop; other site 279808000931 H-loop/switch region; other site 279808000932 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 279808000933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808000934 dimer interface [polypeptide binding]; other site 279808000935 conserved gate region; other site 279808000936 ABC-ATPase subunit interface; other site 279808000937 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 279808000938 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808000939 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808000940 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279808000941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808000942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279808000943 Coenzyme A binding pocket [chemical binding]; other site 279808000944 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 279808000945 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 279808000946 SecY translocase; Region: SecY; pfam00344 279808000947 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 279808000948 Mitochondrial genome maintenance MGM101; Region: Mgm101p; pfam06420 279808000949 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 279808000950 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 279808000951 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 279808000952 DEAD/DEAH box helicase; Region: DEAD; pfam00270 279808000953 ATP binding site [chemical binding]; other site 279808000954 putative Mg++ binding site [ion binding]; other site 279808000955 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 279808000956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279808000957 nucleotide binding region [chemical binding]; other site 279808000958 ATP-binding site [chemical binding]; other site 279808000959 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 279808000960 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 279808000961 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 279808000962 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279808000963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279808000964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808000965 ATP binding site [chemical binding]; other site 279808000966 Mg2+ binding site [ion binding]; other site 279808000967 G-X-G motif; other site 279808000968 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808000969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 279808000970 dimerization interface [polypeptide binding]; other site 279808000971 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 279808000972 DNA binding site [nucleotide binding] 279808000973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808000974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808000975 active site 279808000976 phosphorylation site [posttranslational modification] 279808000977 intermolecular recognition site; other site 279808000978 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808000979 MULE transposase domain; Region: MULE; pfam10551 279808000980 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 279808000981 methionine sulfoxide reductase A; Provisional; Region: PRK05528 279808000982 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 279808000983 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 279808000984 NADP binding site [chemical binding]; other site 279808000985 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808000986 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808000987 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 279808000988 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 279808000989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808000990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279808000991 putative substrate translocation pore; other site 279808000992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808000993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808000994 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 279808000995 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 279808000996 MMPL family; Region: MMPL; pfam03176 279808000997 Protein export membrane protein; Region: SecD_SecF; cl14618 279808000998 MMPL family; Region: MMPL; pfam03176 279808000999 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279808001000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279808001001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279808001002 dimerization interface [polypeptide binding]; other site 279808001003 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279808001004 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 279808001005 active site 279808001006 metal binding site [ion binding]; metal-binding site 279808001007 Predicted membrane protein [Function unknown]; Region: COG1288 279808001008 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 279808001009 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 279808001010 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279808001011 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279808001012 active site turn [active] 279808001013 phosphorylation site [posttranslational modification] 279808001014 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 279808001015 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 279808001016 CHAP domain; Region: CHAP; pfam05257 279808001017 Predicted membrane protein [Function unknown]; Region: COG1511 279808001018 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 279808001019 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 279808001020 YolD-like protein; Region: YolD; pfam08863 279808001021 Arginine repressor [Transcription]; Region: ArgR; COG1438 279808001022 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 279808001023 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 279808001024 arginine deiminase; Provisional; Region: PRK01388 279808001025 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 279808001026 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 279808001027 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 279808001028 ligand binding site [chemical binding]; other site 279808001029 flexible hinge region; other site 279808001030 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 279808001031 Predicted esterase [General function prediction only]; Region: COG0627 279808001032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 279808001033 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279808001034 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279808001035 DNA binding site [nucleotide binding] 279808001036 domain linker motif; other site 279808001037 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 279808001038 putative dimerization interface [polypeptide binding]; other site 279808001039 putative ligand binding site [chemical binding]; other site 279808001040 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279808001041 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 279808001042 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 279808001043 NAD binding site [chemical binding]; other site 279808001044 catalytic Zn binding site [ion binding]; other site 279808001045 substrate binding site [chemical binding]; other site 279808001046 structural Zn binding site [ion binding]; other site 279808001047 SdpI/YhfL protein family; Region: SdpI; pfam13630 279808001048 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 279808001049 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 279808001050 putative active site [active] 279808001051 putative metal binding site [ion binding]; other site 279808001052 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 279808001053 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 279808001054 dimer interface [polypeptide binding]; other site 279808001055 PYR/PP interface [polypeptide binding]; other site 279808001056 TPP binding site [chemical binding]; other site 279808001057 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 279808001058 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 279808001059 TPP-binding site [chemical binding]; other site 279808001060 dimer interface [polypeptide binding]; other site 279808001061 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808001062 MarR family; Region: MarR_2; pfam12802 279808001063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808001064 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808001065 Protein of unknown function (DUF867); Region: DUF867; cl01713 279808001066 Protein of unknown function (DUF867); Region: DUF867; cl01713 279808001067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808001068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808001069 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808001070 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 279808001071 ATP-grasp domain; Region: ATP-grasp_4; cl17255 279808001072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279808001073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808001074 Coenzyme A binding pocket [chemical binding]; other site 279808001075 Bacterial sugar transferase; Region: Bac_transf; pfam02397 279808001076 azoreductase; Reviewed; Region: PRK00170 279808001077 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279808001078 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 279808001079 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 279808001080 Chain length determinant protein; Region: Wzz; cl15801 279808001081 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 279808001082 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 279808001083 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 279808001084 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 279808001085 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 279808001086 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 279808001087 NAD(P) binding site [chemical binding]; other site 279808001088 homodimer interface [polypeptide binding]; other site 279808001089 substrate binding site [chemical binding]; other site 279808001090 active site 279808001091 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 279808001092 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 279808001093 NAD(P) binding site [chemical binding]; other site 279808001094 homodimer interface [polypeptide binding]; other site 279808001095 substrate binding site [chemical binding]; other site 279808001096 active site 279808001097 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 279808001098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808001099 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 279808001100 NAD(P) binding site [chemical binding]; other site 279808001101 active site 279808001102 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 279808001103 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 279808001104 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 279808001105 active site 279808001106 homodimer interface [polypeptide binding]; other site 279808001107 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 279808001108 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279808001109 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279808001110 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 279808001111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279808001112 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 279808001113 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 279808001114 inhibitor-cofactor binding pocket; inhibition site 279808001115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808001116 catalytic residue [active] 279808001117 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 279808001118 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 279808001119 dimer interface [polypeptide binding]; other site 279808001120 Alkaline phosphatase homologues; Region: alkPPc; smart00098 279808001121 active site 279808001122 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 279808001123 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808001124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808001125 active site 279808001126 phosphorylation site [posttranslational modification] 279808001127 intermolecular recognition site; other site 279808001128 dimerization interface [polypeptide binding]; other site 279808001129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279808001130 DNA binding site [nucleotide binding] 279808001131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279808001132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808001133 ATP binding site [chemical binding]; other site 279808001134 Mg2+ binding site [ion binding]; other site 279808001135 G-X-G motif; other site 279808001136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279808001137 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279808001138 Walker A/P-loop; other site 279808001139 ATP binding site [chemical binding]; other site 279808001140 Q-loop/lid; other site 279808001141 ABC transporter signature motif; other site 279808001142 Walker B; other site 279808001143 D-loop; other site 279808001144 H-loop/switch region; other site 279808001145 FtsX-like permease family; Region: FtsX; pfam02687 279808001146 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 279808001147 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 279808001148 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 279808001149 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 279808001150 Active Sites [active] 279808001151 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 279808001152 Flavodoxin; Region: Flavodoxin_1; pfam00258 279808001153 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 279808001154 FAD binding pocket [chemical binding]; other site 279808001155 FAD binding motif [chemical binding]; other site 279808001156 catalytic residues [active] 279808001157 NAD binding pocket [chemical binding]; other site 279808001158 phosphate binding motif [ion binding]; other site 279808001159 beta-alpha-beta structure motif; other site 279808001160 sulfite reductase subunit beta; Provisional; Region: PRK13504 279808001161 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279808001162 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279808001163 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 279808001164 active site 279808001165 SAM binding site [chemical binding]; other site 279808001166 homodimer interface [polypeptide binding]; other site 279808001167 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 279808001168 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 279808001169 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 279808001170 hypothetical protein; Provisional; Region: PRK10621 279808001171 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 279808001172 ATP-sulfurylase; Region: ATPS; cd00517 279808001173 active site 279808001174 HXXH motif; other site 279808001175 flexible loop; other site 279808001176 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 279808001177 AAA domain; Region: AAA_18; pfam13238 279808001178 ligand-binding site [chemical binding]; other site 279808001179 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 279808001180 Citrate transporter; Region: CitMHS; pfam03600 279808001181 CHAP domain; Region: CHAP; pfam05257 279808001182 Surface antigen [General function prediction only]; Region: COG3942 279808001183 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 279808001184 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 279808001185 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 279808001186 Predicted transcriptional regulators [Transcription]; Region: COG1510 279808001187 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 279808001188 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 279808001189 tetramerization interface [polypeptide binding]; other site 279808001190 NAD(P) binding site [chemical binding]; other site 279808001191 catalytic residues [active] 279808001192 choline dehydrogenase; Validated; Region: PRK02106 279808001193 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 279808001194 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279808001195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279808001196 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 279808001197 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279808001198 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 279808001199 metal binding site [ion binding]; metal-binding site 279808001200 dimer interface [polypeptide binding]; other site 279808001201 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279808001202 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279808001203 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 279808001204 metal binding site [ion binding]; metal-binding site 279808001205 dimer interface [polypeptide binding]; other site 279808001206 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 279808001207 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 279808001208 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 279808001209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 279808001210 acyl-activating enzyme (AAE) consensus motif; other site 279808001211 AMP binding site [chemical binding]; other site 279808001212 active site 279808001213 CoA binding site [chemical binding]; other site 279808001214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808001215 active site 279808001216 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 279808001217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808001218 NAD(P) binding site [chemical binding]; other site 279808001219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279808001220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279808001221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279808001222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279808001223 pyruvate phosphate dikinase; Provisional; Region: PRK09279 279808001224 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 279808001225 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 279808001226 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 279808001227 PEP synthetase regulatory protein; Provisional; Region: PRK05339 279808001228 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 279808001229 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 279808001230 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 279808001231 YCII-related domain; Region: YCII; pfam03795 279808001232 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 279808001233 catalytic residue [active] 279808001234 topology modulation protein; Provisional; Region: PRK07261 279808001235 AAA domain; Region: AAA_17; pfam13207 279808001236 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 279808001237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808001238 motif II; other site 279808001239 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 279808001240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808001241 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808001242 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808001243 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 279808001244 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 279808001245 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 279808001246 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279808001247 inhibitor-cofactor binding pocket; inhibition site 279808001248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808001249 catalytic residue [active] 279808001250 amino acid transporter; Region: 2A0306; TIGR00909 279808001251 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 279808001252 acetolactate synthase; Reviewed; Region: PRK08617 279808001253 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 279808001254 PYR/PP interface [polypeptide binding]; other site 279808001255 dimer interface [polypeptide binding]; other site 279808001256 TPP binding site [chemical binding]; other site 279808001257 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 279808001258 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 279808001259 TPP-binding site [chemical binding]; other site 279808001260 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 279808001261 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 279808001262 Double zinc ribbon; Region: DZR; pfam12773 279808001263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808001264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808001265 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 279808001266 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 279808001267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 279808001268 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 279808001269 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 279808001270 quinone interaction residues [chemical binding]; other site 279808001271 active site 279808001272 catalytic residues [active] 279808001273 FMN binding site [chemical binding]; other site 279808001274 substrate binding site [chemical binding]; other site 279808001275 Phosphotransferase enzyme family; Region: APH; pfam01636 279808001276 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 279808001277 active site 279808001278 ATP binding site [chemical binding]; other site 279808001279 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 279808001280 Amidohydrolase; Region: Amidohydro_2; pfam04909 279808001281 active site 279808001282 SnoaL-like domain; Region: SnoaL_4; pfam13577 279808001283 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 279808001284 NADP binding site [chemical binding]; other site 279808001285 active site 279808001286 regulatory binding site [polypeptide binding]; other site 279808001287 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 279808001288 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279808001289 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808001290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808001291 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808001292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 279808001293 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 279808001294 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 279808001295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808001296 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 279808001297 Peptidase family M23; Region: Peptidase_M23; pfam01551 279808001298 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 279808001299 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 279808001300 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 279808001301 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 279808001302 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 279808001303 phytoene desaturase; Region: crtI_fam; TIGR02734 279808001304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 279808001305 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 279808001306 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 279808001307 active site 279808001308 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 279808001309 active site lid residues [active] 279808001310 substrate binding pocket [chemical binding]; other site 279808001311 catalytic residues [active] 279808001312 substrate-Mg2+ binding site; other site 279808001313 aspartate-rich region 1; other site 279808001314 aspartate-rich region 2; other site 279808001315 phytoene desaturase; Region: crtI_fam; TIGR02734 279808001316 transaminase; Reviewed; Region: PRK08068 279808001317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279808001318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808001319 homodimer interface [polypeptide binding]; other site 279808001320 catalytic residue [active] 279808001321 D-lactate dehydrogenase; Validated; Region: PRK08605 279808001322 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 279808001323 homodimer interface [polypeptide binding]; other site 279808001324 ligand binding site [chemical binding]; other site 279808001325 NAD binding site [chemical binding]; other site 279808001326 catalytic site [active] 279808001327 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279808001328 metal-binding site [ion binding] 279808001329 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 279808001330 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279808001331 metal-binding site [ion binding] 279808001332 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 279808001333 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 279808001334 metal-binding site [ion binding] 279808001335 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 279808001336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808001337 motif II; other site 279808001338 short chain dehydrogenase; Provisional; Region: PRK06701 279808001339 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 279808001340 NAD binding site [chemical binding]; other site 279808001341 metal binding site [ion binding]; metal-binding site 279808001342 active site 279808001343 maltose O-acetyltransferase; Provisional; Region: PRK10092 279808001344 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 279808001345 active site 279808001346 substrate binding site [chemical binding]; other site 279808001347 trimer interface [polypeptide binding]; other site 279808001348 CoA binding site [chemical binding]; other site 279808001349 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 279808001350 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 279808001351 Glutamate binding site [chemical binding]; other site 279808001352 homodimer interface [polypeptide binding]; other site 279808001353 NAD binding site [chemical binding]; other site 279808001354 catalytic residues [active] 279808001355 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808001356 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808001357 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 279808001358 dimer interface [polypeptide binding]; other site 279808001359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808001360 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 279808001361 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 279808001362 oligomer interface [polypeptide binding]; other site 279808001363 metal binding site [ion binding]; metal-binding site 279808001364 metal binding site [ion binding]; metal-binding site 279808001365 putative Cl binding site [ion binding]; other site 279808001366 aspartate ring; other site 279808001367 basic sphincter; other site 279808001368 hydrophobic gate; other site 279808001369 periplasmic entrance; other site 279808001370 YrhK-like protein; Region: YrhK; pfam14145 279808001371 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 279808001372 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 279808001373 DNA binding site [nucleotide binding] 279808001374 active site 279808001375 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 279808001376 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 279808001377 dimer interface [polypeptide binding]; other site 279808001378 active site 279808001379 putative acyltransferase; Provisional; Region: PRK05790 279808001380 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 279808001381 dimer interface [polypeptide binding]; other site 279808001382 active site 279808001383 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 279808001384 homodimer interface [polypeptide binding]; other site 279808001385 catalytic residues [active] 279808001386 NAD binding site [chemical binding]; other site 279808001387 substrate binding pocket [chemical binding]; other site 279808001388 flexible flap; other site 279808001389 Surface antigen [General function prediction only]; Region: COG3942 279808001390 CHAP domain; Region: CHAP; pfam05257 279808001391 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 279808001392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279808001393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279808001394 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 279808001395 putative dimerization interface [polypeptide binding]; other site 279808001396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808001397 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808001398 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808001399 LrgA family; Region: LrgA; pfam03788 279808001400 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 279808001401 pyruvate oxidase; Provisional; Region: PRK08611 279808001402 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 279808001403 PYR/PP interface [polypeptide binding]; other site 279808001404 dimer interface [polypeptide binding]; other site 279808001405 tetramer interface [polypeptide binding]; other site 279808001406 TPP binding site [chemical binding]; other site 279808001407 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 279808001408 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 279808001409 TPP-binding site [chemical binding]; other site 279808001410 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808001411 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808001412 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 279808001413 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279808001414 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279808001415 active site turn [active] 279808001416 phosphorylation site [posttranslational modification] 279808001417 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 279808001418 HPr interaction site; other site 279808001419 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279808001420 active site 279808001421 phosphorylation site [posttranslational modification] 279808001422 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 279808001423 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 279808001424 catalytic Zn binding site [ion binding]; other site 279808001425 structural Zn binding site [ion binding]; other site 279808001426 NAD(P) binding site [chemical binding]; other site 279808001427 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 279808001428 active site 279808001429 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279808001430 catalytic residues [active] 279808001431 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 279808001432 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279808001433 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 279808001434 NAD binding site [chemical binding]; other site 279808001435 dimer interface [polypeptide binding]; other site 279808001436 substrate binding site [chemical binding]; other site 279808001437 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 279808001438 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 279808001439 EamA-like transporter family; Region: EamA; pfam00892 279808001440 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279808001441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279808001442 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 279808001443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279808001444 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 279808001445 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 279808001446 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 279808001447 putative active site [active] 279808001448 putative metal binding site [ion binding]; other site 279808001449 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 279808001450 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 279808001451 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 279808001452 N- and C-terminal domain interface [polypeptide binding]; other site 279808001453 D-xylulose kinase; Region: XylB; TIGR01312 279808001454 active site 279808001455 MgATP binding site [chemical binding]; other site 279808001456 catalytic site [active] 279808001457 metal binding site [ion binding]; metal-binding site 279808001458 xylulose binding site [chemical binding]; other site 279808001459 homodimer interface [polypeptide binding]; other site 279808001460 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 279808001461 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 279808001462 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 279808001463 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 279808001464 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 279808001465 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 279808001466 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 279808001467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808001468 Coenzyme A binding pocket [chemical binding]; other site 279808001469 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 279808001470 active site 279808001471 catalytic site [active] 279808001472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808001473 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279808001474 active site 279808001475 motif I; other site 279808001476 motif II; other site 279808001477 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 279808001478 D-lactate dehydrogenase; Provisional; Region: PRK12480 279808001479 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 279808001480 homodimer interface [polypeptide binding]; other site 279808001481 ligand binding site [chemical binding]; other site 279808001482 NAD binding site [chemical binding]; other site 279808001483 catalytic site [active] 279808001484 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 279808001485 dimer interface [polypeptide binding]; other site 279808001486 FMN binding site [chemical binding]; other site 279808001487 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 279808001488 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279808001489 NAD(P) binding site [chemical binding]; other site 279808001490 catalytic residues [active] 279808001491 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 279808001492 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279808001493 substrate binding pocket [chemical binding]; other site 279808001494 membrane-bound complex binding site; other site 279808001495 hinge residues; other site 279808001496 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 279808001497 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 279808001498 putative metal binding site [ion binding]; other site 279808001499 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279808001500 active site 279808001501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808001502 Coenzyme A binding pocket [chemical binding]; other site 279808001503 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279808001504 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 279808001505 intersubunit interface [polypeptide binding]; other site 279808001506 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 279808001507 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279808001508 NAD binding site [chemical binding]; other site 279808001509 catalytic residues [active] 279808001510 substrate binding site [chemical binding]; other site 279808001511 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808001512 MarR family; Region: MarR; pfam01047 279808001513 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279808001514 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 279808001515 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279808001516 Zn binding site [ion binding]; other site 279808001517 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 279808001518 Zn binding site [ion binding]; other site 279808001519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279808001520 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 279808001521 Zn binding site [ion binding]; other site 279808001522 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 279808001523 Zn binding site [ion binding]; other site 279808001524 putative hydrolase; Provisional; Region: PRK11460 279808001525 Predicted esterase [General function prediction only]; Region: COG0400 279808001526 Uncharacterized membrane protein [Function unknown]; Region: COG3949 279808001527 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 279808001528 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 279808001529 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 279808001530 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 279808001531 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 279808001532 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 279808001533 ATP binding site [chemical binding]; other site 279808001534 substrate interface [chemical binding]; other site 279808001535 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 279808001536 ThiS interaction site; other site 279808001537 putative active site [active] 279808001538 tetramer interface [polypeptide binding]; other site 279808001539 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 279808001540 thiS-thiF/thiG interaction site; other site 279808001541 hydroxyglutarate oxidase; Provisional; Region: PRK11728 279808001542 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 279808001543 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 279808001544 thiamine phosphate binding site [chemical binding]; other site 279808001545 active site 279808001546 pyrophosphate binding site [ion binding]; other site 279808001547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808001548 D-galactonate transporter; Region: 2A0114; TIGR00893 279808001549 putative substrate translocation pore; other site 279808001550 Uncharacterized conserved protein [Function unknown]; Region: COG1359 279808001551 Predicted membrane protein [Function unknown]; Region: COG1289 279808001552 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 279808001553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 279808001554 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 279808001555 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 279808001556 synthetase active site [active] 279808001557 NTP binding site [chemical binding]; other site 279808001558 metal binding site [ion binding]; metal-binding site 279808001559 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279808001560 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 279808001561 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 279808001562 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279808001563 DNA binding residues [nucleotide binding] 279808001564 dimer interface [polypeptide binding]; other site 279808001565 Transcriptional regulators [Transcription]; Region: GntR; COG1802 279808001566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279808001567 DNA-binding site [nucleotide binding]; DNA binding site 279808001568 FCD domain; Region: FCD; pfam07729 279808001569 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 279808001570 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 279808001571 N- and C-terminal domain interface [polypeptide binding]; other site 279808001572 active site 279808001573 catalytic site [active] 279808001574 metal binding site [ion binding]; metal-binding site 279808001575 carbohydrate binding site [chemical binding]; other site 279808001576 ATP binding site [chemical binding]; other site 279808001577 GntP family permease; Region: GntP_permease; pfam02447 279808001578 fructuronate transporter; Provisional; Region: PRK10034; cl15264 279808001579 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 279808001580 active site 279808001581 tetramer interface; other site 279808001582 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 279808001583 putative active site [active] 279808001584 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 279808001585 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 279808001586 cofactor binding site; other site 279808001587 DNA binding site [nucleotide binding] 279808001588 substrate interaction site [chemical binding]; other site 279808001589 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 279808001590 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 279808001591 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 279808001592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808001593 NAD(P) binding site [chemical binding]; other site 279808001594 active site 279808001595 acetylornithine deacetylase; Validated; Region: PRK08596 279808001596 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 279808001597 metal binding site [ion binding]; metal-binding site 279808001598 polyphosphate kinase; Provisional; Region: PRK05443 279808001599 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 279808001600 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 279808001601 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 279808001602 putative domain interface [polypeptide binding]; other site 279808001603 putative active site [active] 279808001604 catalytic site [active] 279808001605 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 279808001606 putative domain interface [polypeptide binding]; other site 279808001607 putative active site [active] 279808001608 catalytic site [active] 279808001609 exopolyphosphatase; Region: exo_poly_only; TIGR03706 279808001610 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279808001611 nucleotide binding site [chemical binding]; other site 279808001612 AbgT putative transporter family; Region: ABG_transport; pfam03806 279808001613 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 279808001614 short chain dehydrogenase; Validated; Region: PRK08589 279808001615 classical (c) SDRs; Region: SDR_c; cd05233 279808001616 NAD(P) binding site [chemical binding]; other site 279808001617 active site 279808001618 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 279808001619 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 279808001620 oligomer interface [polypeptide binding]; other site 279808001621 active site 279808001622 metal binding site [ion binding]; metal-binding site 279808001623 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 279808001624 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 279808001625 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279808001626 homodimer interface [polypeptide binding]; other site 279808001627 substrate-cofactor binding pocket; other site 279808001628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808001629 catalytic residue [active] 279808001630 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 279808001631 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 279808001632 active site 279808001633 FMN binding site [chemical binding]; other site 279808001634 substrate binding site [chemical binding]; other site 279808001635 3Fe-4S cluster binding site [ion binding]; other site 279808001636 CAAX protease self-immunity; Region: Abi; cl00558 279808001637 CAAX protease self-immunity; Region: Abi; pfam02517 279808001638 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 279808001639 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279808001640 Walker A/P-loop; other site 279808001641 ATP binding site [chemical binding]; other site 279808001642 Q-loop/lid; other site 279808001643 ABC transporter signature motif; other site 279808001644 Walker B; other site 279808001645 D-loop; other site 279808001646 H-loop/switch region; other site 279808001647 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 279808001648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279808001649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279808001650 dimer interface [polypeptide binding]; other site 279808001651 phosphorylation site [posttranslational modification] 279808001652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808001653 ATP binding site [chemical binding]; other site 279808001654 Mg2+ binding site [ion binding]; other site 279808001655 G-X-G motif; other site 279808001656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808001657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808001658 active site 279808001659 phosphorylation site [posttranslational modification] 279808001660 intermolecular recognition site; other site 279808001661 dimerization interface [polypeptide binding]; other site 279808001662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279808001663 DNA binding site [nucleotide binding] 279808001664 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279808001665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808001666 putative substrate translocation pore; other site 279808001667 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 279808001668 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 279808001669 substrate binding pocket [chemical binding]; other site 279808001670 catalytic triad [active] 279808001671 amino acid transporter; Region: 2A0306; TIGR00909 279808001672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 279808001673 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 279808001674 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 279808001675 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 279808001676 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 279808001677 putative NAD(P) binding site [chemical binding]; other site 279808001678 catalytic Zn binding site [ion binding]; other site 279808001679 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 279808001680 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 279808001681 Walker A/P-loop; other site 279808001682 ATP binding site [chemical binding]; other site 279808001683 Q-loop/lid; other site 279808001684 ABC transporter signature motif; other site 279808001685 Walker B; other site 279808001686 D-loop; other site 279808001687 H-loop/switch region; other site 279808001688 FOG: CBS domain [General function prediction only]; Region: COG0517 279808001689 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 279808001690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808001691 dimer interface [polypeptide binding]; other site 279808001692 conserved gate region; other site 279808001693 putative PBP binding loops; other site 279808001694 ABC-ATPase subunit interface; other site 279808001695 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 279808001696 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 279808001697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808001698 dimer interface [polypeptide binding]; other site 279808001699 conserved gate region; other site 279808001700 ABC-ATPase subunit interface; other site 279808001701 antiholin-like protein LrgB; Provisional; Region: PRK04288 279808001702 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 279808001703 two-component response regulator; Provisional; Region: PRK14084 279808001704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808001705 active site 279808001706 phosphorylation site [posttranslational modification] 279808001707 intermolecular recognition site; other site 279808001708 dimerization interface [polypeptide binding]; other site 279808001709 LytTr DNA-binding domain; Region: LytTR; smart00850 279808001710 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 279808001711 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 279808001712 Histidine kinase; Region: His_kinase; pfam06580 279808001713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808001714 ATP binding site [chemical binding]; other site 279808001715 Mg2+ binding site [ion binding]; other site 279808001716 G-X-G motif; other site 279808001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808001718 putative substrate translocation pore; other site 279808001719 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279808001720 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 279808001721 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 279808001722 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 279808001723 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 279808001724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808001725 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 279808001726 NAD(P) binding site [chemical binding]; other site 279808001727 active site 279808001728 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 279808001729 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 279808001730 Beta-lactamase; Region: Beta-lactamase; pfam00144 279808001731 Amino acid permease; Region: AA_permease_2; pfam13520 279808001732 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 279808001733 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 279808001734 putative phosphoesterase; Region: acc_ester; TIGR03729 279808001735 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 279808001736 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 279808001737 Methyltransferase domain; Region: Methyltransf_31; pfam13847 279808001738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808001739 S-adenosylmethionine binding site [chemical binding]; other site 279808001740 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 279808001741 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 279808001742 Hemerythrin-like domain; Region: Hr-like; cd12108 279808001743 Fe binding site [ion binding]; other site 279808001744 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 279808001745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808001746 putative substrate translocation pore; other site 279808001747 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 279808001748 Predicted membrane protein [Function unknown]; Region: COG2246 279808001749 GtrA-like protein; Region: GtrA; pfam04138 279808001750 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 279808001751 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 279808001752 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 279808001753 catalytic core [active] 279808001754 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 279808001755 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279808001756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808001757 putative substrate translocation pore; other site 279808001758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808001759 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 279808001760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279808001761 substrate binding pocket [chemical binding]; other site 279808001762 membrane-bound complex binding site; other site 279808001763 hinge residues; other site 279808001764 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 279808001765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808001766 dimer interface [polypeptide binding]; other site 279808001767 conserved gate region; other site 279808001768 putative PBP binding loops; other site 279808001769 ABC-ATPase subunit interface; other site 279808001770 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 279808001771 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 279808001772 Walker A/P-loop; other site 279808001773 ATP binding site [chemical binding]; other site 279808001774 Q-loop/lid; other site 279808001775 ABC transporter signature motif; other site 279808001776 Walker B; other site 279808001777 D-loop; other site 279808001778 H-loop/switch region; other site 279808001779 FemAB family; Region: FemAB; pfam02388 279808001780 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 279808001781 Thioredoxin; Region: Thioredoxin_4; cl17273 279808001782 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 279808001783 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279808001784 intersubunit interface [polypeptide binding]; other site 279808001785 YodA lipocalin-like domain; Region: YodA; pfam09223 279808001786 Uncharacterized conserved protein [Function unknown]; Region: COG2353 279808001787 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 279808001788 putative hydrophobic ligand binding site [chemical binding]; other site 279808001789 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 279808001790 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 279808001791 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 279808001792 putative active site [active] 279808001793 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 279808001794 active site 279808001795 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 279808001796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808001797 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808001798 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 279808001799 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 279808001800 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 279808001801 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 279808001802 [2Fe-2S] cluster binding site [ion binding]; other site 279808001803 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 279808001804 active site 279808001805 SAM binding site [chemical binding]; other site 279808001806 homodimer interface [polypeptide binding]; other site 279808001807 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 279808001808 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 279808001809 [4Fe-4S] binding site [ion binding]; other site 279808001810 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279808001811 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279808001812 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 279808001813 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 279808001814 molybdopterin cofactor binding site; other site 279808001815 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 279808001816 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 279808001817 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 279808001818 GAF domain; Region: GAF; cl17456 279808001819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279808001820 Histidine kinase; Region: HisKA_3; pfam07730 279808001821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808001822 ATP binding site [chemical binding]; other site 279808001823 Mg2+ binding site [ion binding]; other site 279808001824 G-X-G motif; other site 279808001825 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279808001826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808001827 active site 279808001828 phosphorylation site [posttranslational modification] 279808001829 intermolecular recognition site; other site 279808001830 dimerization interface [polypeptide binding]; other site 279808001831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279808001832 DNA binding residues [nucleotide binding] 279808001833 dimerization interface [polypeptide binding]; other site 279808001834 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 279808001835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808001836 putative substrate translocation pore; other site 279808001837 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 279808001838 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 279808001839 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808001840 MarR family; Region: MarR_2; cl17246 279808001841 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 279808001842 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 279808001843 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279808001844 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 279808001845 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279808001846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279808001847 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 279808001848 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 279808001849 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279808001850 active site turn [active] 279808001851 phosphorylation site [posttranslational modification] 279808001852 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279808001853 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 279808001854 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 279808001855 Cl binding site [ion binding]; other site 279808001856 oligomer interface [polypeptide binding]; other site 279808001857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808001858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808001859 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 279808001860 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 279808001861 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 279808001862 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 279808001863 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808001864 MarR family; Region: MarR_2; pfam12802 279808001865 MarR family; Region: MarR_2; cl17246 279808001866 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 279808001867 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 279808001868 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 279808001869 CopC domain; Region: CopC; pfam04234 279808001870 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 279808001871 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 279808001872 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 279808001873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808001874 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808001875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808001876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279808001877 Coenzyme A binding pocket [chemical binding]; other site 279808001878 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 279808001879 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 279808001880 NAD(P) binding site [chemical binding]; other site 279808001881 Imelysin; Region: Peptidase_M75; pfam09375 279808001882 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 279808001883 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 279808001884 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 279808001885 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 279808001886 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 279808001887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 279808001888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808001889 Coenzyme A binding pocket [chemical binding]; other site 279808001890 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 279808001891 L-lactate permease; Region: Lactate_perm; cl00701 279808001892 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 279808001893 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279808001894 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 279808001895 putative ADP-binding pocket [chemical binding]; other site 279808001896 malate:quinone oxidoreductase; Validated; Region: PRK05257 279808001897 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 279808001898 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 279808001899 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 279808001900 LytTr DNA-binding domain; Region: LytTR; pfam04397 279808001901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279808001902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279808001903 dimerization interface [polypeptide binding]; other site 279808001904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279808001905 dimer interface [polypeptide binding]; other site 279808001906 phosphorylation site [posttranslational modification] 279808001907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808001908 ATP binding site [chemical binding]; other site 279808001909 Mg2+ binding site [ion binding]; other site 279808001910 G-X-G motif; other site 279808001911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808001912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808001913 active site 279808001914 phosphorylation site [posttranslational modification] 279808001915 intermolecular recognition site; other site 279808001916 dimerization interface [polypeptide binding]; other site 279808001917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279808001918 DNA binding site [nucleotide binding] 279808001919 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 279808001920 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 279808001921 FtsX-like permease family; Region: FtsX; pfam02687 279808001922 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279808001923 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279808001924 Walker A/P-loop; other site 279808001925 ATP binding site [chemical binding]; other site 279808001926 Q-loop/lid; other site 279808001927 ABC transporter signature motif; other site 279808001928 Walker B; other site 279808001929 D-loop; other site 279808001930 H-loop/switch region; other site 279808001931 Uncharacterized conserved protein [Function unknown]; Region: COG1434 279808001932 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 279808001933 putative active site [active] 279808001934 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808001935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279808001936 putative Zn2+ binding site [ion binding]; other site 279808001937 putative DNA binding site [nucleotide binding]; other site 279808001938 Predicted membrane protein [Function unknown]; Region: COG4640 279808001939 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 279808001940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808001941 putative substrate translocation pore; other site 279808001942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808001943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808001944 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 279808001945 HlyD family secretion protein; Region: HlyD_3; pfam13437 279808001946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808001947 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279808001948 putative substrate translocation pore; other site 279808001949 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 279808001950 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 279808001951 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 279808001952 active site 279808001953 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 279808001954 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 279808001955 oligomer interface [polypeptide binding]; other site 279808001956 metal binding site [ion binding]; metal-binding site 279808001957 metal binding site [ion binding]; metal-binding site 279808001958 putative Cl binding site [ion binding]; other site 279808001959 aspartate ring; other site 279808001960 basic sphincter; other site 279808001961 hydrophobic gate; other site 279808001962 periplasmic entrance; other site 279808001963 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 279808001964 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 279808001965 homotetramer interface [polypeptide binding]; other site 279808001966 FMN binding site [chemical binding]; other site 279808001967 homodimer contacts [polypeptide binding]; other site 279808001968 putative active site [active] 279808001969 putative substrate binding site [chemical binding]; other site 279808001970 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 279808001971 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 279808001972 active site 279808001973 DNA binding site [nucleotide binding] 279808001974 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808001975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808001976 non-specific DNA binding site [nucleotide binding]; other site 279808001977 salt bridge; other site 279808001978 sequence-specific DNA binding site [nucleotide binding]; other site 279808001979 hypothetical protein; Provisional; Region: PRK02237 279808001980 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 279808001981 active site 279808001982 catalytic residues [active] 279808001983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 279808001984 MOSC domain; Region: MOSC; pfam03473 279808001985 3-alpha domain; Region: 3-alpha; pfam03475 279808001986 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 279808001987 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279808001988 active site 279808001989 dimer interface [polypeptide binding]; other site 279808001990 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808001991 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808001992 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 279808001993 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 279808001994 putative active site [active] 279808001995 putative metal binding site [ion binding]; other site 279808001996 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 279808001997 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 279808001998 Sulfate transporter family; Region: Sulfate_transp; pfam00916 279808001999 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 279808002000 Sulfate transporter family; Region: Sulfate_transp; pfam00916 279808002001 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279808002002 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 279808002003 metal binding site [ion binding]; metal-binding site 279808002004 oxidoreductase; Provisional; Region: PRK07985 279808002005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808002006 NAD(P) binding site [chemical binding]; other site 279808002007 active site 279808002008 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 279808002009 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 279808002010 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 279808002011 putative hydrophobic ligand binding site [chemical binding]; other site 279808002012 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279808002013 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279808002014 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279808002015 putative active site [active] 279808002016 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 279808002017 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279808002018 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279808002019 active site turn [active] 279808002020 phosphorylation site [posttranslational modification] 279808002021 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 279808002022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808002023 motif II; other site 279808002024 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 279808002025 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279808002026 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 279808002027 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 279808002028 putative active site [active] 279808002029 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 279808002030 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279808002031 active site turn [active] 279808002032 phosphorylation site [posttranslational modification] 279808002033 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279808002034 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 279808002035 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 279808002036 putative active site [active] 279808002037 Uncharacterized conserved protein [Function unknown]; Region: COG3589 279808002038 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 279808002039 Predicted transcriptional regulator [Transcription]; Region: COG2378 279808002040 HTH domain; Region: HTH_11; pfam08279 279808002041 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 279808002042 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 279808002043 active site 279808002044 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 279808002045 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 279808002046 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 279808002047 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 279808002048 4Fe-4S binding domain; Region: Fer4; pfam00037 279808002049 4Fe-4S binding domain; Region: Fer4; pfam00037 279808002050 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 279808002051 [4Fe-4S] binding site [ion binding]; other site 279808002052 molybdopterin cofactor binding site; other site 279808002053 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 279808002054 molybdopterin cofactor binding site; other site 279808002055 Uncharacterized conserved protein [Function unknown]; Region: COG2427 279808002056 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 279808002057 Lysozyme subfamily 2; Region: LYZ2; smart00047 279808002058 hypothetical protein; Provisional; Region: PRK06753 279808002059 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 279808002060 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 279808002061 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 279808002062 putative ligand binding site [chemical binding]; other site 279808002063 putative NAD binding site [chemical binding]; other site 279808002064 catalytic site [active] 279808002065 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 279808002066 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 279808002067 CHAP domain; Region: CHAP; pfam05257 279808002068 Surface antigen [General function prediction only]; Region: COG3942 279808002069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 279808002070 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 279808002071 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 279808002072 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 279808002073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808002074 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808002075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808002076 Integrase core domain; Region: rve; pfam00665 279808002077 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808002078 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808002079 Surface antigen [General function prediction only]; Region: COG3942 279808002080 CHAP domain; Region: CHAP; pfam05257 279808002081 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279808002082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279808002083 MarR family; Region: MarR_2; cl17246 279808002084 MarR family; Region: MarR_2; cl17246 279808002085 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 279808002086 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 279808002087 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279808002088 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279808002089 intersubunit interface [polypeptide binding]; other site 279808002090 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 279808002091 active site 279808002092 dimerization interface [polypeptide binding]; other site 279808002093 BioY family; Region: BioY; pfam02632 279808002094 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 279808002095 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 279808002096 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 279808002097 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 279808002098 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 279808002099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808002100 dimer interface [polypeptide binding]; other site 279808002101 conserved gate region; other site 279808002102 putative PBP binding loops; other site 279808002103 ABC-ATPase subunit interface; other site 279808002104 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279808002105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808002106 Walker A/P-loop; other site 279808002107 ATP binding site [chemical binding]; other site 279808002108 Q-loop/lid; other site 279808002109 ABC transporter signature motif; other site 279808002110 Walker B; other site 279808002111 D-loop; other site 279808002112 H-loop/switch region; other site 279808002113 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 279808002114 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 279808002115 ATP binding site [chemical binding]; other site 279808002116 substrate interface [chemical binding]; other site 279808002117 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 279808002118 MPT binding site; other site 279808002119 trimer interface [polypeptide binding]; other site 279808002120 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 279808002121 trimer interface [polypeptide binding]; other site 279808002122 dimer interface [polypeptide binding]; other site 279808002123 putative active site [active] 279808002124 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 279808002125 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 279808002126 dimer interface [polypeptide binding]; other site 279808002127 putative functional site; other site 279808002128 putative MPT binding site; other site 279808002129 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 279808002130 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 279808002131 MoaE homodimer interface [polypeptide binding]; other site 279808002132 MoaD interaction [polypeptide binding]; other site 279808002133 active site residues [active] 279808002134 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 279808002135 MoaE interaction surface [polypeptide binding]; other site 279808002136 MoeB interaction surface [polypeptide binding]; other site 279808002137 thiocarboxylated glycine; other site 279808002138 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 279808002139 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 279808002140 GTP binding site; other site 279808002141 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 279808002142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279808002143 FeS/SAM binding site; other site 279808002144 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 279808002145 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 279808002146 Transcriptional regulators [Transcription]; Region: MarR; COG1846 279808002147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808002148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279808002149 putative substrate translocation pore; other site 279808002150 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808002151 MarR family; Region: MarR_2; pfam12802 279808002152 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 279808002153 FemAB family; Region: FemAB; pfam02388 279808002154 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 279808002155 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 279808002156 Protein export membrane protein; Region: SecD_SecF; cl14618 279808002157 Predicted permeases [General function prediction only]; Region: COG0679 279808002158 glucose-1-dehydrogenase; Provisional; Region: PRK08936 279808002159 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 279808002160 NAD binding site [chemical binding]; other site 279808002161 homodimer interface [polypeptide binding]; other site 279808002162 active site 279808002163 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 279808002164 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 279808002165 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279808002166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808002167 Coenzyme A binding pocket [chemical binding]; other site 279808002168 DNA topoisomerase III; Provisional; Region: PRK07726 279808002169 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 279808002170 active site 279808002171 putative interdomain interaction site [polypeptide binding]; other site 279808002172 putative metal-binding site [ion binding]; other site 279808002173 putative nucleotide binding site [chemical binding]; other site 279808002174 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 279808002175 domain I; other site 279808002176 DNA binding groove [nucleotide binding] 279808002177 phosphate binding site [ion binding]; other site 279808002178 domain II; other site 279808002179 domain III; other site 279808002180 nucleotide binding site [chemical binding]; other site 279808002181 catalytic site [active] 279808002182 domain IV; other site 279808002183 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 279808002184 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 279808002185 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 279808002186 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 279808002187 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 279808002188 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 279808002189 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 279808002190 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 279808002191 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 279808002192 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 279808002193 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 279808002194 putative translocon binding site; other site 279808002195 protein-rRNA interface [nucleotide binding]; other site 279808002196 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 279808002197 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 279808002198 G-X-X-G motif; other site 279808002199 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 279808002200 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 279808002201 23S rRNA interface [nucleotide binding]; other site 279808002202 5S rRNA interface [nucleotide binding]; other site 279808002203 putative antibiotic binding site [chemical binding]; other site 279808002204 L25 interface [polypeptide binding]; other site 279808002205 L27 interface [polypeptide binding]; other site 279808002206 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 279808002207 23S rRNA interface [nucleotide binding]; other site 279808002208 putative translocon interaction site; other site 279808002209 signal recognition particle (SRP54) interaction site; other site 279808002210 L23 interface [polypeptide binding]; other site 279808002211 trigger factor interaction site; other site 279808002212 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 279808002213 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 279808002214 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 279808002215 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 279808002216 RNA binding site [nucleotide binding]; other site 279808002217 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 279808002218 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 279808002219 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 279808002220 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 279808002221 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 279808002222 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 279808002223 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 279808002224 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 279808002225 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 279808002226 5S rRNA interface [nucleotide binding]; other site 279808002227 L27 interface [polypeptide binding]; other site 279808002228 23S rRNA interface [nucleotide binding]; other site 279808002229 L5 interface [polypeptide binding]; other site 279808002230 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 279808002231 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 279808002232 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 279808002233 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 279808002234 23S rRNA binding site [nucleotide binding]; other site 279808002235 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 279808002236 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 279808002237 SecY translocase; Region: SecY; pfam00344 279808002238 adenylate kinase; Reviewed; Region: adk; PRK00279 279808002239 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 279808002240 AMP-binding site [chemical binding]; other site 279808002241 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 279808002242 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 279808002243 rRNA binding site [nucleotide binding]; other site 279808002244 predicted 30S ribosome binding site; other site 279808002245 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 279808002246 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 279808002247 30S ribosomal protein S13; Region: bact_S13; TIGR03631 279808002248 30S ribosomal protein S11; Validated; Region: PRK05309 279808002249 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 279808002250 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 279808002251 alphaNTD homodimer interface [polypeptide binding]; other site 279808002252 alphaNTD - beta interaction site [polypeptide binding]; other site 279808002253 alphaNTD - beta' interaction site [polypeptide binding]; other site 279808002254 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 279808002255 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 279808002256 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808002257 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808002258 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 279808002259 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279808002260 Walker A/P-loop; other site 279808002261 ATP binding site [chemical binding]; other site 279808002262 Q-loop/lid; other site 279808002263 ABC transporter signature motif; other site 279808002264 Walker B; other site 279808002265 D-loop; other site 279808002266 H-loop/switch region; other site 279808002267 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 279808002268 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279808002269 Walker A/P-loop; other site 279808002270 ATP binding site [chemical binding]; other site 279808002271 Q-loop/lid; other site 279808002272 ABC transporter signature motif; other site 279808002273 Walker B; other site 279808002274 D-loop; other site 279808002275 H-loop/switch region; other site 279808002276 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 279808002277 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 279808002278 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 279808002279 dimerization interface 3.5A [polypeptide binding]; other site 279808002280 active site 279808002281 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 279808002282 23S rRNA interface [nucleotide binding]; other site 279808002283 L3 interface [polypeptide binding]; other site 279808002284 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 279808002285 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 279808002286 NAD-dependent deacetylase; Provisional; Region: PRK00481 279808002287 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 279808002288 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279808002289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279808002290 DNA-binding site [nucleotide binding]; DNA binding site 279808002291 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 279808002292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808002293 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808002294 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808002295 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 279808002296 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 279808002297 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 279808002298 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 279808002299 putative substrate binding site [chemical binding]; other site 279808002300 putative ATP binding site [chemical binding]; other site 279808002301 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 279808002302 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 279808002303 methionine cluster; other site 279808002304 active site 279808002305 phosphorylation site [posttranslational modification] 279808002306 metal binding site [ion binding]; metal-binding site 279808002307 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 279808002308 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 279808002309 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 279808002310 active site 279808002311 P-loop; other site 279808002312 phosphorylation site [posttranslational modification] 279808002313 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 279808002314 beta-galactosidase; Region: BGL; TIGR03356 279808002315 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 279808002316 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 279808002317 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 279808002318 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 279808002319 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 279808002320 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 279808002321 putative NAD(P) binding site [chemical binding]; other site 279808002322 dimer interface [polypeptide binding]; other site 279808002323 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 279808002324 Small integral membrane protein [Function unknown]; Region: COG5547 279808002325 Asp23 family; Region: Asp23; pfam03780 279808002326 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808002327 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808002328 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808002329 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 279808002330 IucA / IucC family; Region: IucA_IucC; pfam04183 279808002331 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 279808002332 H+ Antiporter protein; Region: 2A0121; TIGR00900 279808002333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808002334 putative substrate translocation pore; other site 279808002335 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 279808002336 IucA / IucC family; Region: IucA_IucC; pfam04183 279808002337 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 279808002338 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 279808002339 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 279808002340 dimer interface [polypeptide binding]; other site 279808002341 active site 279808002342 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279808002343 substrate binding site [chemical binding]; other site 279808002344 catalytic residue [active] 279808002345 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 279808002346 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279808002347 siderophore binding site; other site 279808002348 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279808002349 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279808002350 ABC-ATPase subunit interface; other site 279808002351 dimer interface [polypeptide binding]; other site 279808002352 putative PBP binding regions; other site 279808002353 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279808002354 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279808002355 ABC-ATPase subunit interface; other site 279808002356 dimer interface [polypeptide binding]; other site 279808002357 putative PBP binding regions; other site 279808002358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 279808002359 Nucleoside recognition; Region: Gate; pfam07670 279808002360 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13315 279808002361 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 279808002362 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 279808002363 substrate binding site; other site 279808002364 dimerization interface; other site 279808002365 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 279808002366 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 279808002367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808002368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808002369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808002370 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 279808002371 putative substrate translocation pore; other site 279808002372 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 279808002373 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 279808002374 Walker A motif; other site 279808002375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808002376 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808002377 Uncharacterized conserved protein [Function unknown]; Region: COG1624 279808002378 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 279808002379 YbbR-like protein; Region: YbbR; pfam07949 279808002380 YbbR-like protein; Region: YbbR; pfam07949 279808002381 YbbR-like protein; Region: YbbR; pfam07949 279808002382 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 279808002383 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 279808002384 active site 279808002385 substrate binding site [chemical binding]; other site 279808002386 metal binding site [ion binding]; metal-binding site 279808002387 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 279808002388 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 279808002389 glutaminase active site [active] 279808002390 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 279808002391 dimer interface [polypeptide binding]; other site 279808002392 active site 279808002393 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 279808002394 dimer interface [polypeptide binding]; other site 279808002395 active site 279808002396 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 279808002397 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279808002398 Walker A/P-loop; other site 279808002399 ATP binding site [chemical binding]; other site 279808002400 Q-loop/lid; other site 279808002401 ABC transporter signature motif; other site 279808002402 Walker B; other site 279808002403 D-loop; other site 279808002404 H-loop/switch region; other site 279808002405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808002406 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279808002407 active site 279808002408 motif I; other site 279808002409 motif II; other site 279808002410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808002411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808002412 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808002413 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 279808002414 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279808002415 active site 279808002416 metal binding site [ion binding]; metal-binding site 279808002417 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 279808002418 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 279808002419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279808002420 dimerization interface [polypeptide binding]; other site 279808002421 putative DNA binding site [nucleotide binding]; other site 279808002422 putative Zn2+ binding site [ion binding]; other site 279808002423 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279808002424 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 279808002425 NAD(P) binding site [chemical binding]; other site 279808002426 putative active site [active] 279808002427 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 279808002428 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 279808002429 EVE domain; Region: EVE; cl00728 279808002430 Protein of unknown function, DUF393; Region: DUF393; cl01136 279808002431 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 279808002432 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 279808002433 dimerization interface [polypeptide binding]; other site 279808002434 DPS ferroxidase diiron center [ion binding]; other site 279808002435 ion pore; other site 279808002436 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 279808002437 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 279808002438 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 279808002439 intersubunit interface [polypeptide binding]; other site 279808002440 active site 279808002441 catalytic residue [active] 279808002442 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 279808002443 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 279808002444 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279808002445 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 279808002446 phosphopentomutase; Provisional; Region: PRK05362 279808002447 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 279808002448 Predicted membrane protein [Function unknown]; Region: COG4270 279808002449 S-ribosylhomocysteinase; Provisional; Region: PRK02260 279808002450 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279808002451 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 279808002452 metal binding site [ion binding]; metal-binding site 279808002453 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 279808002454 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 279808002455 pantothenate kinase; Provisional; Region: PRK13317 279808002456 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 279808002457 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279808002458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808002459 Coenzyme A binding pocket [chemical binding]; other site 279808002460 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 279808002461 CTP synthetase; Validated; Region: pyrG; PRK05380 279808002462 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 279808002463 Catalytic site [active] 279808002464 active site 279808002465 UTP binding site [chemical binding]; other site 279808002466 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 279808002467 active site 279808002468 putative oxyanion hole; other site 279808002469 catalytic triad [active] 279808002470 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 279808002471 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 279808002472 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 279808002473 intersubunit interface [polypeptide binding]; other site 279808002474 active site 279808002475 zinc binding site [ion binding]; other site 279808002476 Na+ binding site [ion binding]; other site 279808002477 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 279808002478 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 279808002479 hinge; other site 279808002480 active site 279808002481 Predicted transcriptional regulators [Transcription]; Region: COG1733 279808002482 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 279808002483 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 279808002484 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 279808002485 NAD binding site [chemical binding]; other site 279808002486 catalytic residues [active] 279808002487 transcription termination factor Rho; Provisional; Region: rho; PRK09376 279808002488 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 279808002489 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 279808002490 RNA binding site [nucleotide binding]; other site 279808002491 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 279808002492 multimer interface [polypeptide binding]; other site 279808002493 Walker A motif; other site 279808002494 ATP binding site [chemical binding]; other site 279808002495 Walker B motif; other site 279808002496 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 279808002497 thymidine kinase; Provisional; Region: PRK04296 279808002498 peptide chain release factor 1; Validated; Region: prfA; PRK00591 279808002499 This domain is found in peptide chain release factors; Region: PCRF; smart00937 279808002500 RF-1 domain; Region: RF-1; pfam00472 279808002501 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 279808002502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808002503 S-adenosylmethionine binding site [chemical binding]; other site 279808002504 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 279808002505 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 279808002506 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279808002507 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 279808002508 active site 279808002509 hypothetical protein; Provisional; Region: PRK13690 279808002510 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 279808002511 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 279808002512 dimer interface [polypeptide binding]; other site 279808002513 active site 279808002514 glycine-pyridoxal phosphate binding site [chemical binding]; other site 279808002515 folate binding site [chemical binding]; other site 279808002516 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279808002517 active site 279808002518 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 279808002519 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 279808002520 active site 279808002521 homodimer interface [polypeptide binding]; other site 279808002522 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 279808002523 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 279808002524 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 279808002525 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 279808002526 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 279808002527 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 279808002528 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 279808002529 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 279808002530 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 279808002531 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 279808002532 beta subunit interaction interface [polypeptide binding]; other site 279808002533 Walker A motif; other site 279808002534 ATP binding site [chemical binding]; other site 279808002535 Walker B motif; other site 279808002536 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 279808002537 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 279808002538 core domain interface [polypeptide binding]; other site 279808002539 delta subunit interface [polypeptide binding]; other site 279808002540 epsilon subunit interface [polypeptide binding]; other site 279808002541 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 279808002542 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 279808002543 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 279808002544 alpha subunit interaction interface [polypeptide binding]; other site 279808002545 Walker A motif; other site 279808002546 ATP binding site [chemical binding]; other site 279808002547 Walker B motif; other site 279808002548 inhibitor binding site; inhibition site 279808002549 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 279808002550 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 279808002551 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 279808002552 gamma subunit interface [polypeptide binding]; other site 279808002553 epsilon subunit interface [polypeptide binding]; other site 279808002554 LBP interface [polypeptide binding]; other site 279808002555 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 279808002556 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 279808002557 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 279808002558 hinge; other site 279808002559 active site 279808002560 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 279808002561 YwpF-like protein; Region: YwpF; pfam14183 279808002562 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 279808002563 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 279808002564 dimer interface [polypeptide binding]; other site 279808002565 ssDNA binding site [nucleotide binding]; other site 279808002566 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279808002567 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 279808002568 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279808002569 catalytic residue [active] 279808002570 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 279808002571 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 279808002572 substrate binding site [chemical binding]; other site 279808002573 dimer interface [polypeptide binding]; other site 279808002574 ATP binding site [chemical binding]; other site 279808002575 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 279808002576 substrate binding site [chemical binding]; other site 279808002577 multimerization interface [polypeptide binding]; other site 279808002578 ATP binding site [chemical binding]; other site 279808002579 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 279808002580 thiamine phosphate binding site [chemical binding]; other site 279808002581 active site 279808002582 pyrophosphate binding site [ion binding]; other site 279808002583 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 279808002584 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808002585 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808002586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 279808002587 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 279808002588 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 279808002589 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 279808002590 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 279808002591 putative active site [active] 279808002592 catalytic site [active] 279808002593 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 279808002594 putative active site [active] 279808002595 catalytic site [active] 279808002596 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 279808002597 putative homodimer interface [polypeptide binding]; other site 279808002598 putative homotetramer interface [polypeptide binding]; other site 279808002599 allosteric switch controlling residues; other site 279808002600 putative metal binding site [ion binding]; other site 279808002601 putative homodimer-homodimer interface [polypeptide binding]; other site 279808002602 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 279808002603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808002604 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808002605 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808002606 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 279808002607 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 279808002608 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 279808002609 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 279808002610 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 279808002611 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 279808002612 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279808002613 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279808002614 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 279808002615 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 279808002616 ATP binding site [chemical binding]; other site 279808002617 Mg++ binding site [ion binding]; other site 279808002618 motif III; other site 279808002619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279808002620 nucleotide binding region [chemical binding]; other site 279808002621 ATP-binding site [chemical binding]; other site 279808002622 Bacterial PH domain; Region: DUF304; cl01348 279808002623 Predicted membrane protein [Function unknown]; Region: COG3428 279808002624 Bacterial PH domain; Region: DUF304; pfam03703 279808002625 Bacterial PH domain; Region: DUF304; pfam03703 279808002626 Uncharacterized conserved protein [Function unknown]; Region: COG3402 279808002627 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 279808002628 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 279808002629 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 279808002630 active site 279808002631 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279808002632 dimer interface [polypeptide binding]; other site 279808002633 substrate binding site [chemical binding]; other site 279808002634 catalytic residues [active] 279808002635 PemK-like protein; Region: PemK; pfam02452 279808002636 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 279808002637 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 279808002638 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 279808002639 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 279808002640 anti sigma factor interaction site; other site 279808002641 regulatory phosphorylation site [posttranslational modification]; other site 279808002642 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 279808002643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808002644 ATP binding site [chemical binding]; other site 279808002645 Mg2+ binding site [ion binding]; other site 279808002646 G-X-G motif; other site 279808002647 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 279808002648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279808002649 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279808002650 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279808002651 DNA binding residues [nucleotide binding] 279808002652 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 279808002653 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 279808002654 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 279808002655 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 279808002656 RNA binding site [nucleotide binding]; other site 279808002657 hypothetical protein; Provisional; Region: PRK04351 279808002658 SprT homologues; Region: SprT; cl01182 279808002659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808002660 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808002661 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808002662 threonine dehydratase; Validated; Region: PRK08639 279808002663 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 279808002664 tetramer interface [polypeptide binding]; other site 279808002665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808002666 catalytic residue [active] 279808002667 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 279808002668 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 279808002669 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 279808002670 substrate binding site [chemical binding]; other site 279808002671 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 279808002672 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 279808002673 substrate binding site [chemical binding]; other site 279808002674 ligand binding site [chemical binding]; other site 279808002675 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 279808002676 tartrate dehydrogenase; Region: TTC; TIGR02089 279808002677 2-isopropylmalate synthase; Validated; Region: PRK00915 279808002678 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 279808002679 active site 279808002680 catalytic residues [active] 279808002681 metal binding site [ion binding]; metal-binding site 279808002682 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 279808002683 ketol-acid reductoisomerase; Provisional; Region: PRK05479 279808002684 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 279808002685 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 279808002686 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 279808002687 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 279808002688 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 279808002689 PYR/PP interface [polypeptide binding]; other site 279808002690 dimer interface [polypeptide binding]; other site 279808002691 TPP binding site [chemical binding]; other site 279808002692 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 279808002693 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 279808002694 TPP-binding site [chemical binding]; other site 279808002695 dimer interface [polypeptide binding]; other site 279808002696 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 279808002697 6-phosphogluconate dehydratase; Region: edd; TIGR01196 279808002698 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 279808002699 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 279808002700 Glycoprotease family; Region: Peptidase_M22; pfam00814 279808002701 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 279808002702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808002703 Coenzyme A binding pocket [chemical binding]; other site 279808002704 UGMP family protein; Validated; Region: PRK09604 279808002705 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 279808002706 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279808002707 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808002708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808002709 ABC transporter; Region: ABC_tran_2; pfam12848 279808002710 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808002711 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 279808002712 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 279808002713 CoA binding domain; Region: CoA_binding; pfam02629 279808002714 Predicted transporter component [General function prediction only]; Region: COG2391 279808002715 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 279808002716 Sulphur transport; Region: Sulf_transp; pfam04143 279808002717 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 279808002718 CPxP motif; other site 279808002719 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 279808002720 Transcriptional regulators [Transcription]; Region: PurR; COG1609 279808002721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279808002722 DNA binding site [nucleotide binding] 279808002723 domain linker motif; other site 279808002724 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 279808002725 dimerization interface [polypeptide binding]; other site 279808002726 ligand binding site [chemical binding]; other site 279808002727 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 279808002728 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 279808002729 substrate binding [chemical binding]; other site 279808002730 active site 279808002731 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 279808002732 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279808002733 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 279808002734 putative substrate binding site [chemical binding]; other site 279808002735 putative ATP binding site [chemical binding]; other site 279808002736 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 279808002737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808002738 active site 279808002739 phosphorylation site [posttranslational modification] 279808002740 intermolecular recognition site; other site 279808002741 dimerization interface [polypeptide binding]; other site 279808002742 LytTr DNA-binding domain; Region: LytTR; pfam04397 279808002743 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 279808002744 ATP binding site [chemical binding]; other site 279808002745 Mg2+ binding site [ion binding]; other site 279808002746 G-X-G motif; other site 279808002747 Staphylococcal AgrD protein; Region: AgrD; pfam05931 279808002748 Accessory gene regulator B; Region: AgrB; smart00793 279808002749 Predicted amidohydrolase [General function prediction only]; Region: COG0388 279808002750 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 279808002751 putative active site [active] 279808002752 catalytic triad [active] 279808002753 putative dimer interface [polypeptide binding]; other site 279808002754 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 279808002755 dimer interface [polypeptide binding]; other site 279808002756 FMN binding site [chemical binding]; other site 279808002757 CAAX protease self-immunity; Region: Abi; pfam02517 279808002758 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 279808002759 oligomerisation interface [polypeptide binding]; other site 279808002760 mobile loop; other site 279808002761 roof hairpin; other site 279808002762 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 279808002763 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 279808002764 ring oligomerisation interface [polypeptide binding]; other site 279808002765 ATP/Mg binding site [chemical binding]; other site 279808002766 stacking interactions; other site 279808002767 hinge regions; other site 279808002768 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 279808002769 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 279808002770 Int/Topo IB signature motif; other site 279808002771 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808002772 MULE transposase domain; Region: MULE; pfam10551 279808002773 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 279808002774 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808002775 MULE transposase domain; Region: MULE; pfam10551 279808002776 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 279808002777 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 279808002778 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 279808002779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279808002780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808002781 homodimer interface [polypeptide binding]; other site 279808002782 catalytic residue [active] 279808002783 Predicted transcriptional regulators [Transcription]; Region: COG1725 279808002784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279808002785 DNA-binding site [nucleotide binding]; DNA binding site 279808002786 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279808002787 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279808002788 Walker A/P-loop; other site 279808002789 ATP binding site [chemical binding]; other site 279808002790 Q-loop/lid; other site 279808002791 ABC transporter signature motif; other site 279808002792 Walker B; other site 279808002793 D-loop; other site 279808002794 H-loop/switch region; other site 279808002795 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 279808002796 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279808002797 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279808002798 Walker A/P-loop; other site 279808002799 ATP binding site [chemical binding]; other site 279808002800 Q-loop/lid; other site 279808002801 ABC transporter signature motif; other site 279808002802 Walker B; other site 279808002803 D-loop; other site 279808002804 H-loop/switch region; other site 279808002805 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 279808002806 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 279808002807 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 279808002808 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 279808002809 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 279808002810 active site 279808002811 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 279808002812 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 279808002813 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 279808002814 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 279808002815 NAD(P) binding site [chemical binding]; other site 279808002816 catalytic residues [active] 279808002817 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 279808002818 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 279808002819 DHHA2 domain; Region: DHHA2; pfam02833 279808002820 Isochorismatase family; Region: Isochorismatase; pfam00857 279808002821 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 279808002822 catalytic triad [active] 279808002823 conserved cis-peptide bond; other site 279808002824 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 279808002825 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 279808002826 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 279808002827 Prephenate dehydratase; Region: PDT; pfam00800 279808002828 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 279808002829 putative L-Phe binding site [chemical binding]; other site 279808002830 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 279808002831 active site 279808002832 dimer interface [polypeptide binding]; other site 279808002833 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 279808002834 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 279808002835 active site 279808002836 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 279808002837 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 279808002838 homodimer interface [polypeptide binding]; other site 279808002839 NAD binding pocket [chemical binding]; other site 279808002840 ATP binding pocket [chemical binding]; other site 279808002841 Mg binding site [ion binding]; other site 279808002842 active-site loop [active] 279808002843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 279808002844 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 279808002845 NETI protein; Region: NETI; pfam14044 279808002846 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 279808002847 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 279808002848 tetramer interface [polypeptide binding]; other site 279808002849 active site 279808002850 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 279808002851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 279808002852 PcrB family; Region: PcrB; pfam01884 279808002853 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 279808002854 substrate binding site [chemical binding]; other site 279808002855 putative active site [active] 279808002856 dimer interface [polypeptide binding]; other site 279808002857 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 279808002858 Part of AAA domain; Region: AAA_19; pfam13245 279808002859 Family description; Region: UvrD_C_2; pfam13538 279808002860 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 279808002861 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 279808002862 nucleotide binding pocket [chemical binding]; other site 279808002863 K-X-D-G motif; other site 279808002864 catalytic site [active] 279808002865 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 279808002866 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 279808002867 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 279808002868 Dimer interface [polypeptide binding]; other site 279808002869 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 279808002870 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 279808002871 putative dimer interface [polypeptide binding]; other site 279808002872 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 279808002873 putative dimer interface [polypeptide binding]; other site 279808002874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808002875 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808002876 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 279808002877 Na binding site [ion binding]; other site 279808002878 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 279808002879 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 279808002880 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 279808002881 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 279808002882 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 279808002883 GatB domain; Region: GatB_Yqey; pfam02637 279808002884 putative lipid kinase; Reviewed; Region: PRK13337 279808002885 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 279808002886 TRAM domain; Region: TRAM; cl01282 279808002887 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 279808002888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808002889 S-adenosylmethionine binding site [chemical binding]; other site 279808002890 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 279808002891 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 279808002892 active site 279808002893 DNA polymerase IV; Validated; Region: PRK02406 279808002894 DNA binding site [nucleotide binding] 279808002895 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 279808002896 active site 279808002897 catalytic site [active] 279808002898 substrate binding site [chemical binding]; other site 279808002899 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 279808002900 Ferritin-like domain; Region: Ferritin; pfam00210 279808002901 ferroxidase diiron center [ion binding]; other site 279808002902 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 279808002903 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279808002904 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 279808002905 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 279808002906 catalytic triad [active] 279808002907 Predicted membrane protein [Function unknown]; Region: COG4129 279808002908 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 279808002909 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 279808002910 active site 279808002911 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 279808002912 NADP binding site [chemical binding]; other site 279808002913 active site 279808002914 steroid binding site; other site 279808002915 High-affinity nickel-transport protein; Region: NicO; cl00964 279808002916 High-affinity nickel-transport protein; Region: NicO; cl00964 279808002917 Predicted membrane protein [Function unknown]; Region: COG4758 279808002918 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 279808002919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279808002920 Histidine kinase; Region: HisKA_3; pfam07730 279808002921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808002922 ATP binding site [chemical binding]; other site 279808002923 Mg2+ binding site [ion binding]; other site 279808002924 G-X-G motif; other site 279808002925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279808002926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808002927 active site 279808002928 phosphorylation site [posttranslational modification] 279808002929 intermolecular recognition site; other site 279808002930 dimerization interface [polypeptide binding]; other site 279808002931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279808002932 DNA binding residues [nucleotide binding] 279808002933 dimerization interface [polypeptide binding]; other site 279808002934 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808002935 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808002936 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 279808002937 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 279808002938 Low molecular weight phosphatase family; Region: LMWPc; cd00115 279808002939 active site 279808002940 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 279808002941 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 279808002942 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 279808002943 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 279808002944 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 279808002945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808002946 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808002947 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808002948 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808002949 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808002950 Radical SAM superfamily; Region: Radical_SAM; pfam04055 279808002951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279808002952 FeS/SAM binding site; other site 279808002953 YfkB-like domain; Region: YfkB; pfam08756 279808002954 intracellular protease, PfpI family; Region: PfpI; TIGR01382 279808002955 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 279808002956 proposed catalytic triad [active] 279808002957 conserved cys residue [active] 279808002958 glycosyltransferase; Provisional; Region: PRK13481 279808002959 Transglycosylase; Region: Transgly; pfam00912 279808002960 recombination regulator RecX; Provisional; Region: recX; PRK14135 279808002961 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 279808002962 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 279808002963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808002964 Walker A/P-loop; other site 279808002965 ATP binding site [chemical binding]; other site 279808002966 ABC transporter signature motif; other site 279808002967 Walker B; other site 279808002968 D-loop; other site 279808002969 H-loop/switch region; other site 279808002970 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808002971 MULE transposase domain; Region: MULE; pfam10551 279808002972 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 279808002973 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 279808002974 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 279808002975 minor groove reading motif; other site 279808002976 helix-hairpin-helix signature motif; other site 279808002977 substrate binding pocket [chemical binding]; other site 279808002978 active site 279808002979 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 279808002980 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 279808002981 DNA binding and oxoG recognition site [nucleotide binding] 279808002982 hypothetical protein; Provisional; Region: PRK13662 279808002983 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279808002984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279808002985 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 279808002986 Walker A/P-loop; other site 279808002987 ATP binding site [chemical binding]; other site 279808002988 Q-loop/lid; other site 279808002989 ABC transporter signature motif; other site 279808002990 Walker B; other site 279808002991 D-loop; other site 279808002992 H-loop/switch region; other site 279808002993 Predicted membrane protein [Function unknown]; Region: COG4129 279808002994 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 279808002995 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 279808002996 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279808002997 inhibitor-cofactor binding pocket; inhibition site 279808002998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808002999 catalytic residue [active] 279808003000 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 279808003001 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 279808003002 catalytic triad [active] 279808003003 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 279808003004 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 279808003005 NAD binding site [chemical binding]; other site 279808003006 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808003007 MULE transposase domain; Region: MULE; pfam10551 279808003008 ferric uptake regulator; Provisional; Region: fur; PRK09462 279808003009 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279808003010 metal binding site 2 [ion binding]; metal-binding site 279808003011 putative DNA binding helix; other site 279808003012 metal binding site 1 [ion binding]; metal-binding site 279808003013 dimer interface [polypeptide binding]; other site 279808003014 structural Zn2+ binding site [ion binding]; other site 279808003015 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 279808003016 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 279808003017 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 279808003018 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 279808003019 substrate binding pocket [chemical binding]; other site 279808003020 membrane-bound complex binding site; other site 279808003021 hinge residues; other site 279808003022 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 279808003023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808003024 dimer interface [polypeptide binding]; other site 279808003025 conserved gate region; other site 279808003026 putative PBP binding loops; other site 279808003027 ABC-ATPase subunit interface; other site 279808003028 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 279808003029 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 279808003030 Walker A/P-loop; other site 279808003031 ATP binding site [chemical binding]; other site 279808003032 Q-loop/lid; other site 279808003033 ABC transporter signature motif; other site 279808003034 Walker B; other site 279808003035 D-loop; other site 279808003036 H-loop/switch region; other site 279808003037 epoxyqueuosine reductase; Region: TIGR00276 279808003038 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 279808003039 HEAT repeats; Region: HEAT_2; pfam13646 279808003040 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 279808003041 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 279808003042 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 279808003043 active site 279808003044 fumarate hydratase; Reviewed; Region: fumC; PRK00485 279808003045 Class II fumarases; Region: Fumarase_classII; cd01362 279808003046 active site 279808003047 tetramer interface [polypeptide binding]; other site 279808003048 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 279808003049 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 279808003050 active site 279808003051 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 279808003052 GAF domain; Region: GAF_3; pfam13492 279808003053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279808003054 Histidine kinase; Region: HisKA_3; pfam07730 279808003055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808003056 ATP binding site [chemical binding]; other site 279808003057 Mg2+ binding site [ion binding]; other site 279808003058 G-X-G motif; other site 279808003059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279808003060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808003061 active site 279808003062 phosphorylation site [posttranslational modification] 279808003063 intermolecular recognition site; other site 279808003064 dimerization interface [polypeptide binding]; other site 279808003065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279808003066 DNA binding residues [nucleotide binding] 279808003067 dimerization interface [polypeptide binding]; other site 279808003068 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808003069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808003070 non-specific DNA binding site [nucleotide binding]; other site 279808003071 salt bridge; other site 279808003072 sequence-specific DNA binding site [nucleotide binding]; other site 279808003073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 279808003074 hypothetical protein; Provisional; Region: PRK13676 279808003075 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 279808003076 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 279808003077 active site 279808003078 metal binding site [ion binding]; metal-binding site 279808003079 DNA binding site [nucleotide binding] 279808003080 Uncharacterized conserved protein [Function unknown]; Region: COG4717 279808003081 P-loop containing region of AAA domain; Region: AAA_29; cl17516 279808003082 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 279808003083 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 279808003084 generic binding surface II; other site 279808003085 generic binding surface I; other site 279808003086 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279808003087 Zn2+ binding site [ion binding]; other site 279808003088 Mg2+ binding site [ion binding]; other site 279808003089 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 279808003090 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 279808003091 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 279808003092 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 279808003093 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 279808003094 HIT family signature motif; other site 279808003095 catalytic residue [active] 279808003096 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 279808003097 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279808003098 Walker A/P-loop; other site 279808003099 ATP binding site [chemical binding]; other site 279808003100 Q-loop/lid; other site 279808003101 ABC transporter signature motif; other site 279808003102 Walker B; other site 279808003103 D-loop; other site 279808003104 H-loop/switch region; other site 279808003105 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 279808003106 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 279808003107 substrate binding site [chemical binding]; other site 279808003108 active site 279808003109 ferrochelatase; Provisional; Region: PRK12435 279808003110 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 279808003111 C-terminal domain interface [polypeptide binding]; other site 279808003112 active site 279808003113 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 279808003114 active site 279808003115 N-terminal domain interface [polypeptide binding]; other site 279808003116 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 279808003117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 279808003118 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 279808003119 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 279808003120 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 279808003121 acyl-activating enzyme (AAE) consensus motif; other site 279808003122 putative AMP binding site [chemical binding]; other site 279808003123 putative active site [active] 279808003124 putative CoA binding site [chemical binding]; other site 279808003125 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 279808003126 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 279808003127 metal binding site [ion binding]; metal-binding site 279808003128 substrate binding pocket [chemical binding]; other site 279808003129 Haemolytic domain; Region: Haemolytic; pfam01809 279808003130 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 279808003131 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 279808003132 nudix motif; other site 279808003133 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 279808003134 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 279808003135 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 279808003136 active site 279808003137 substrate-binding site [chemical binding]; other site 279808003138 metal-binding site [ion binding] 279808003139 ATP binding site [chemical binding]; other site 279808003140 S-adenosylmethionine synthetase; Validated; Region: PRK05250 279808003141 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 279808003142 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 279808003143 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 279808003144 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279808003145 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279808003146 active site 279808003147 catalytic tetrad [active] 279808003148 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 279808003149 camphor resistance protein CrcB; Provisional; Region: PRK14201 279808003150 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 279808003151 active site 279808003152 intersubunit interactions; other site 279808003153 catalytic residue [active] 279808003154 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 279808003155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279808003156 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 279808003157 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 279808003158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808003159 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808003160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 279808003161 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 279808003162 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 279808003163 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 279808003164 catalytic motif [active] 279808003165 Zn binding site [ion binding]; other site 279808003166 RibD C-terminal domain; Region: RibD_C; cl17279 279808003167 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 279808003168 Lumazine binding domain; Region: Lum_binding; pfam00677 279808003169 Lumazine binding domain; Region: Lum_binding; pfam00677 279808003170 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 279808003171 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 279808003172 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 279808003173 dimerization interface [polypeptide binding]; other site 279808003174 active site 279808003175 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 279808003176 homopentamer interface [polypeptide binding]; other site 279808003177 active site 279808003178 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 279808003179 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 279808003180 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279808003181 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 279808003182 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 279808003183 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 279808003184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808003185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279808003186 putative substrate translocation pore; other site 279808003187 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 279808003188 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 279808003189 HIGH motif; other site 279808003190 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 279808003191 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 279808003192 active site 279808003193 KMSKS motif; other site 279808003194 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 279808003195 tRNA binding surface [nucleotide binding]; other site 279808003196 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279808003197 active site residue [active] 279808003198 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 279808003199 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 279808003200 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003201 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003202 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003203 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003204 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003205 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003206 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 279808003207 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 279808003208 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 279808003209 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003210 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003211 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003212 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003213 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003214 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 279808003215 HI0933-like protein; Region: HI0933_like; pfam03486 279808003216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808003217 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 279808003218 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 279808003219 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 279808003220 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279808003221 RNA binding surface [nucleotide binding]; other site 279808003222 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 279808003223 active site 279808003224 uracil binding [chemical binding]; other site 279808003225 YtxH-like protein; Region: YtxH; pfam12732 279808003226 dipeptidase PepV; Reviewed; Region: PRK07318 279808003227 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 279808003228 active site 279808003229 metal binding site [ion binding]; metal-binding site 279808003230 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 279808003231 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 279808003232 homodimer interface [polypeptide binding]; other site 279808003233 substrate-cofactor binding pocket; other site 279808003234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808003235 catalytic residue [active] 279808003236 Phosphotransferase enzyme family; Region: APH; pfam01636 279808003237 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 279808003238 substrate binding site [chemical binding]; other site 279808003239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808003240 S-adenosylmethionine binding site [chemical binding]; other site 279808003241 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 279808003242 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 279808003243 Predicted small secreted protein [Function unknown]; Region: COG5584 279808003244 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 279808003245 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 279808003246 oligomer interface [polypeptide binding]; other site 279808003247 active site 279808003248 metal binding site [ion binding]; metal-binding site 279808003249 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279808003250 catalytic residues [active] 279808003251 hypothetical protein; Provisional; Region: PRK13668 279808003252 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 279808003253 putative tRNA-binding site [nucleotide binding]; other site 279808003254 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 279808003255 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 279808003256 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 279808003257 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 279808003258 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 279808003259 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279808003260 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279808003261 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 279808003262 YtxH-like protein; Region: YtxH; pfam12732 279808003263 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 279808003264 Chorismate mutase type II; Region: CM_2; cl00693 279808003265 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 279808003266 catabolite control protein A; Region: ccpA; TIGR01481 279808003267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 279808003268 DNA binding site [nucleotide binding] 279808003269 domain linker motif; other site 279808003270 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 279808003271 dimerization interface [polypeptide binding]; other site 279808003272 effector binding site; other site 279808003273 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 279808003274 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 279808003275 active site 279808003276 Zn binding site [ion binding]; other site 279808003277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279808003278 Coenzyme A binding pocket [chemical binding]; other site 279808003279 acetyl-CoA synthetase; Provisional; Region: PRK04319 279808003280 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 279808003281 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 279808003282 active site 279808003283 acyl-activating enzyme (AAE) consensus motif; other site 279808003284 putative CoA binding site [chemical binding]; other site 279808003285 AMP binding site [chemical binding]; other site 279808003286 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 279808003287 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 279808003288 Potassium binding sites [ion binding]; other site 279808003289 Cesium cation binding sites [ion binding]; other site 279808003290 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 279808003291 Transglycosylase; Region: Transgly; pfam00912 279808003292 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 279808003293 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 279808003294 active site 279808003295 HIGH motif; other site 279808003296 dimer interface [polypeptide binding]; other site 279808003297 KMSKS motif; other site 279808003298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279808003299 RNA binding surface [nucleotide binding]; other site 279808003300 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808003301 MarR family; Region: MarR; pfam01047 279808003302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808003303 putative substrate translocation pore; other site 279808003304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808003305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808003306 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808003307 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 279808003308 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279808003309 protein binding site [polypeptide binding]; other site 279808003310 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 279808003311 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 279808003312 putative acyl-acceptor binding pocket; other site 279808003313 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 279808003314 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279808003315 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279808003316 active site turn [active] 279808003317 phosphorylation site [posttranslational modification] 279808003318 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 279808003319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808003320 motif II; other site 279808003321 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 279808003322 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 279808003323 ligand binding site [chemical binding]; other site 279808003324 NAD binding site [chemical binding]; other site 279808003325 dimerization interface [polypeptide binding]; other site 279808003326 catalytic site [active] 279808003327 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 279808003328 putative L-serine binding site [chemical binding]; other site 279808003329 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 279808003330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279808003331 catalytic residue [active] 279808003332 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 279808003333 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279808003334 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 279808003335 active site 279808003336 catalytic site [active] 279808003337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808003338 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808003339 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808003340 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 279808003341 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 279808003342 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279808003343 RNA binding surface [nucleotide binding]; other site 279808003344 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 279808003345 GAF domain; Region: GAF_2; pfam13185 279808003346 septation ring formation regulator EzrA; Provisional; Region: PRK04778 279808003347 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 279808003348 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 279808003349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279808003350 catalytic residue [active] 279808003351 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 279808003352 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 279808003353 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 279808003354 Ligand Binding Site [chemical binding]; other site 279808003355 hypothetical protein; Provisional; Region: PRK10621 279808003356 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 279808003357 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 279808003358 dimer interface [polypeptide binding]; other site 279808003359 catalytic triad [active] 279808003360 peroxidatic and resolving cysteines [active] 279808003361 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 279808003362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808003363 S-adenosylmethionine binding site [chemical binding]; other site 279808003364 propionate/acetate kinase; Provisional; Region: PRK12379 279808003365 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 279808003366 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 279808003367 Ligand Binding Site [chemical binding]; other site 279808003368 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 279808003369 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 279808003370 hexamer interface [polypeptide binding]; other site 279808003371 ligand binding site [chemical binding]; other site 279808003372 putative active site [active] 279808003373 NAD(P) binding site [chemical binding]; other site 279808003374 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 279808003375 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 279808003376 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 279808003377 active site 279808003378 metal-dependent hydrolase; Provisional; Region: PRK00685 279808003379 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 279808003380 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 279808003381 Ligand Binding Site [chemical binding]; other site 279808003382 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 279808003383 DRTGG domain; Region: DRTGG; pfam07085 279808003384 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 279808003385 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 279808003386 DHH family; Region: DHH; pfam01368 279808003387 DHHA1 domain; Region: DHHA1; pfam02272 279808003388 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 279808003389 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 279808003390 active site 279808003391 PHP Thumb interface [polypeptide binding]; other site 279808003392 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 279808003393 generic binding surface I; other site 279808003394 generic binding surface II; other site 279808003395 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 279808003396 Malic enzyme, N-terminal domain; Region: malic; pfam00390 279808003397 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 279808003398 putative NAD(P) binding site [chemical binding]; other site 279808003399 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 279808003400 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 279808003401 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 279808003402 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 279808003403 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 279808003404 6-phosphofructokinase; Provisional; Region: PRK03202 279808003405 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 279808003406 dimerization interface [polypeptide binding]; other site 279808003407 allosteric effector site; other site 279808003408 active site 279808003409 ADP/pyrophosphate binding site [chemical binding]; other site 279808003410 fructose-1,6-bisphosphate binding site; other site 279808003411 pyruvate kinase; Provisional; Region: PRK06354 279808003412 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 279808003413 domain interfaces; other site 279808003414 active site 279808003415 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 279808003416 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 279808003417 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 279808003418 FMN binding site [chemical binding]; other site 279808003419 active site 279808003420 catalytic residues [active] 279808003421 substrate binding site [chemical binding]; other site 279808003422 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 279808003423 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 279808003424 dimer interface [polypeptide binding]; other site 279808003425 Citrate synthase; Region: Citrate_synt; pfam00285 279808003426 active site 279808003427 citrylCoA binding site [chemical binding]; other site 279808003428 oxalacetate/citrate binding site [chemical binding]; other site 279808003429 coenzyme A binding site [chemical binding]; other site 279808003430 catalytic triad [active] 279808003431 isocitrate dehydrogenase; Reviewed; Region: PRK07006 279808003432 isocitrate dehydrogenase; Validated; Region: PRK07362 279808003433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808003434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808003435 active site 279808003436 phosphorylation site [posttranslational modification] 279808003437 intermolecular recognition site; other site 279808003438 dimerization interface [polypeptide binding]; other site 279808003439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279808003440 DNA binding site [nucleotide binding] 279808003441 HAMP domain; Region: HAMP; pfam00672 279808003442 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279808003443 PAS domain; Region: PAS; smart00091 279808003444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279808003445 dimer interface [polypeptide binding]; other site 279808003446 phosphorylation site [posttranslational modification] 279808003447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808003448 ATP binding site [chemical binding]; other site 279808003449 Mg2+ binding site [ion binding]; other site 279808003450 G-X-G motif; other site 279808003451 DNA polymerase I; Provisional; Region: PRK05755 279808003452 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 279808003453 active site 279808003454 metal binding site 1 [ion binding]; metal-binding site 279808003455 putative 5' ssDNA interaction site; other site 279808003456 metal binding site 3; metal-binding site 279808003457 metal binding site 2 [ion binding]; metal-binding site 279808003458 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 279808003459 putative DNA binding site [nucleotide binding]; other site 279808003460 putative metal binding site [ion binding]; other site 279808003461 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 279808003462 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 279808003463 active site 279808003464 DNA binding site [nucleotide binding] 279808003465 catalytic site [active] 279808003466 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 279808003467 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 279808003468 DNA binding site [nucleotide binding] 279808003469 catalytic residue [active] 279808003470 H2TH interface [polypeptide binding]; other site 279808003471 putative catalytic residues [active] 279808003472 turnover-facilitating residue; other site 279808003473 intercalation triad [nucleotide binding]; other site 279808003474 8OG recognition residue [nucleotide binding]; other site 279808003475 putative reading head residues; other site 279808003476 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 279808003477 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 279808003478 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 279808003479 dephospho-CoA kinase; Region: TIGR00152 279808003480 CoA-binding site [chemical binding]; other site 279808003481 ATP-binding [chemical binding]; other site 279808003482 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 279808003483 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 279808003484 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 279808003485 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 279808003486 ATP cone domain; Region: ATP-cone; pfam03477 279808003487 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 279808003488 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 279808003489 primosomal protein DnaI; Reviewed; Region: PRK08939 279808003490 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 279808003491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808003492 Walker A motif; other site 279808003493 ATP binding site [chemical binding]; other site 279808003494 Walker B motif; other site 279808003495 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 279808003496 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 279808003497 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 279808003498 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 279808003499 active site 279808003500 dimer interface [polypeptide binding]; other site 279808003501 motif 1; other site 279808003502 motif 2; other site 279808003503 motif 3; other site 279808003504 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 279808003505 anticodon binding site; other site 279808003506 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 279808003507 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 279808003508 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 279808003509 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 279808003510 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 279808003511 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 279808003512 23S rRNA binding site [nucleotide binding]; other site 279808003513 L21 binding site [polypeptide binding]; other site 279808003514 L13 binding site [polypeptide binding]; other site 279808003515 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 279808003516 trigger factor; Provisional; Region: tig; PRK01490 279808003517 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 279808003518 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 279808003519 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 279808003520 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 279808003521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808003522 Walker A motif; other site 279808003523 ATP binding site [chemical binding]; other site 279808003524 Walker B motif; other site 279808003525 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 279808003526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808003527 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808003528 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808003529 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 279808003530 G1 box; other site 279808003531 GTP/Mg2+ binding site [chemical binding]; other site 279808003532 Switch I region; other site 279808003533 G2 box; other site 279808003534 G3 box; other site 279808003535 Switch II region; other site 279808003536 G4 box; other site 279808003537 G5 box; other site 279808003538 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 279808003539 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 279808003540 tRNA; other site 279808003541 putative tRNA binding site [nucleotide binding]; other site 279808003542 putative NADP binding site [chemical binding]; other site 279808003543 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 279808003544 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 279808003545 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 279808003546 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 279808003547 domain interfaces; other site 279808003548 active site 279808003549 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 279808003550 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 279808003551 active site 279808003552 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 279808003553 dimer interface [polypeptide binding]; other site 279808003554 active site 279808003555 Schiff base residues; other site 279808003556 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 279808003557 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279808003558 inhibitor-cofactor binding pocket; inhibition site 279808003559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808003560 catalytic residue [active] 279808003561 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 279808003562 Putative ammonia monooxygenase; Region: AmoA; pfam05145 279808003563 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 279808003564 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 279808003565 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 279808003566 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 279808003567 active site 279808003568 HIGH motif; other site 279808003569 nucleotide binding site [chemical binding]; other site 279808003570 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 279808003571 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 279808003572 active site 279808003573 KMSKS motif; other site 279808003574 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 279808003575 tRNA binding surface [nucleotide binding]; other site 279808003576 anticodon binding site; other site 279808003577 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 279808003578 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 279808003579 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279808003580 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279808003581 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 279808003582 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 279808003583 hypothetical protein; Reviewed; Region: PRK00024 279808003584 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 279808003585 MPN+ (JAMM) motif; other site 279808003586 Zinc-binding site [ion binding]; other site 279808003587 rod shape-determining protein MreC; Provisional; Region: PRK13922 279808003588 rod shape-determining protein MreC; Region: MreC; pfam04085 279808003589 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 279808003590 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 279808003591 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 279808003592 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 279808003593 GTPase CgtA; Reviewed; Region: obgE; PRK12297 279808003594 GTP1/OBG; Region: GTP1_OBG; pfam01018 279808003595 Obg GTPase; Region: Obg; cd01898 279808003596 G1 box; other site 279808003597 GTP/Mg2+ binding site [chemical binding]; other site 279808003598 Switch I region; other site 279808003599 G2 box; other site 279808003600 G3 box; other site 279808003601 Switch II region; other site 279808003602 G4 box; other site 279808003603 G5 box; other site 279808003604 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 279808003605 hypothetical protein; Provisional; Region: PRK04435 279808003606 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 279808003607 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 279808003608 RuvA N terminal domain; Region: RuvA_N; pfam01330 279808003609 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 279808003610 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 279808003611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808003612 Walker A motif; other site 279808003613 ATP binding site [chemical binding]; other site 279808003614 Walker B motif; other site 279808003615 arginine finger; other site 279808003616 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 279808003617 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 279808003618 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 279808003619 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 279808003620 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 279808003621 Preprotein translocase subunit; Region: YajC; pfam02699 279808003622 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 279808003623 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 279808003624 Protein export membrane protein; Region: SecD_SecF; cl14618 279808003625 Protein export membrane protein; Region: SecD_SecF; pfam02355 279808003626 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 279808003627 DHH family; Region: DHH; pfam01368 279808003628 DHHA1 domain; Region: DHHA1; pfam02272 279808003629 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 279808003630 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279808003631 active site 279808003632 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 279808003633 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279808003634 Zn2+ binding site [ion binding]; other site 279808003635 Mg2+ binding site [ion binding]; other site 279808003636 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 279808003637 synthetase active site [active] 279808003638 NTP binding site [chemical binding]; other site 279808003639 metal binding site [ion binding]; metal-binding site 279808003640 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 279808003641 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 279808003642 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 279808003643 dimerization interface [polypeptide binding]; other site 279808003644 putative tRNAtyr binding site [nucleotide binding]; other site 279808003645 putative active site [active] 279808003646 Bacterial SH3 domain homologues; Region: SH3b; smart00287 279808003647 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 279808003648 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279808003649 active site 279808003650 metal binding site [ion binding]; metal-binding site 279808003651 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 279808003652 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 279808003653 dimer interface [polypeptide binding]; other site 279808003654 motif 1; other site 279808003655 active site 279808003656 motif 2; other site 279808003657 motif 3; other site 279808003658 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 279808003659 anticodon binding site; other site 279808003660 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 279808003661 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 279808003662 dimer interface [polypeptide binding]; other site 279808003663 anticodon binding site; other site 279808003664 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 279808003665 homodimer interface [polypeptide binding]; other site 279808003666 motif 1; other site 279808003667 active site 279808003668 motif 2; other site 279808003669 GAD domain; Region: GAD; pfam02938 279808003670 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 279808003671 motif 3; other site 279808003672 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 279808003673 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 279808003674 putative ATP binding site [chemical binding]; other site 279808003675 putative substrate interface [chemical binding]; other site 279808003676 recombination factor protein RarA; Reviewed; Region: PRK13342 279808003677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808003678 Walker A motif; other site 279808003679 ATP binding site [chemical binding]; other site 279808003680 Walker B motif; other site 279808003681 arginine finger; other site 279808003682 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 279808003683 Predicted transcriptional regulator [Transcription]; Region: COG1959 279808003684 Transcriptional regulator; Region: Rrf2; pfam02082 279808003685 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 279808003686 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 279808003687 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 279808003688 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 279808003689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279808003690 catalytic residue [active] 279808003691 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 279808003692 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 279808003693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279808003694 TPR motif; other site 279808003695 binding surface 279808003696 TPR repeat; Region: TPR_11; pfam13414 279808003697 TPR repeat; Region: TPR_11; pfam13414 279808003698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279808003699 binding surface 279808003700 TPR motif; other site 279808003701 TPR repeat; Region: TPR_11; pfam13414 279808003702 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 279808003703 AAA domain; Region: AAA_30; pfam13604 279808003704 Family description; Region: UvrD_C_2; pfam13538 279808003705 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 279808003706 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 279808003707 motif 1; other site 279808003708 active site 279808003709 motif 2; other site 279808003710 motif 3; other site 279808003711 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 279808003712 DHHA1 domain; Region: DHHA1; pfam02272 279808003713 hypothetical protein; Provisional; Region: PRK05473 279808003714 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 279808003715 hypothetical protein; Provisional; Region: PRK13678 279808003716 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 279808003717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808003718 S-adenosylmethionine binding site [chemical binding]; other site 279808003719 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 279808003720 Peptidase family U32; Region: Peptidase_U32; pfam01136 279808003721 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 279808003722 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 279808003723 Peptidase family U32; Region: Peptidase_U32; pfam01136 279808003724 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 279808003725 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 279808003726 Sugar specificity; other site 279808003727 Pyrimidine base specificity; other site 279808003728 ATP-binding site [chemical binding]; other site 279808003729 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 279808003730 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 279808003731 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 279808003732 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 279808003733 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 279808003734 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 279808003735 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 279808003736 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279808003737 carboxyltransferase (CT) interaction site; other site 279808003738 biotinylation site [posttranslational modification]; other site 279808003739 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279808003740 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 279808003741 ATP-grasp domain; Region: ATP-grasp_4; cl17255 279808003742 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 279808003743 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 279808003744 putative active site [active] 279808003745 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 279808003746 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 279808003747 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 279808003748 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 279808003749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808003750 active site 279808003751 motif I; other site 279808003752 motif II; other site 279808003753 GTPase YqeH; Provisional; Region: PRK13796 279808003754 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 279808003755 GTP/Mg2+ binding site [chemical binding]; other site 279808003756 G4 box; other site 279808003757 G5 box; other site 279808003758 G1 box; other site 279808003759 Switch I region; other site 279808003760 G2 box; other site 279808003761 G3 box; other site 279808003762 Switch II region; other site 279808003763 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 279808003764 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 279808003765 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 279808003766 shikimate binding site; other site 279808003767 NAD(P) binding site [chemical binding]; other site 279808003768 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 279808003769 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 279808003770 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 279808003771 active site 279808003772 (T/H)XGH motif; other site 279808003773 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279808003774 Zn2+ binding site [ion binding]; other site 279808003775 Mg2+ binding site [ion binding]; other site 279808003776 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 279808003777 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 279808003778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808003779 S-adenosylmethionine binding site [chemical binding]; other site 279808003780 comEA protein; Region: comE; TIGR01259 279808003781 Helix-hairpin-helix motif; Region: HHH; pfam00633 279808003782 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 279808003783 catalytic motif [active] 279808003784 Zn binding site [ion binding]; other site 279808003785 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 279808003786 Competence protein; Region: Competence; pfam03772 279808003787 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 279808003788 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279808003789 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 279808003790 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 279808003791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808003792 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808003793 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808003794 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 279808003795 GTP-binding protein LepA; Provisional; Region: PRK05433 279808003796 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 279808003797 G1 box; other site 279808003798 putative GEF interaction site [polypeptide binding]; other site 279808003799 GTP/Mg2+ binding site [chemical binding]; other site 279808003800 Switch I region; other site 279808003801 G2 box; other site 279808003802 G3 box; other site 279808003803 Switch II region; other site 279808003804 G4 box; other site 279808003805 G5 box; other site 279808003806 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 279808003807 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 279808003808 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 279808003809 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 279808003810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279808003811 FeS/SAM binding site; other site 279808003812 HemN C-terminal domain; Region: HemN_C; pfam06969 279808003813 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 279808003814 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 279808003815 heat shock protein GrpE; Provisional; Region: PRK14140 279808003816 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 279808003817 dimer interface [polypeptide binding]; other site 279808003818 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 279808003819 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 279808003820 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 279808003821 nucleotide binding site [chemical binding]; other site 279808003822 NEF interaction site [polypeptide binding]; other site 279808003823 SBD interface [polypeptide binding]; other site 279808003824 chaperone protein DnaJ; Provisional; Region: PRK14280 279808003825 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 279808003826 HSP70 interaction site [polypeptide binding]; other site 279808003827 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 279808003828 substrate binding site [polypeptide binding]; other site 279808003829 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 279808003830 Zn binding sites [ion binding]; other site 279808003831 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 279808003832 dimer interface [polypeptide binding]; other site 279808003833 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 279808003834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808003835 S-adenosylmethionine binding site [chemical binding]; other site 279808003836 RNA methyltransferase, RsmE family; Region: TIGR00046 279808003837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 279808003838 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 279808003839 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 279808003840 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279808003841 FeS/SAM binding site; other site 279808003842 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 279808003843 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 279808003844 hypothetical protein; Provisional; Region: PRK13665 279808003845 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 279808003846 PhoH-like protein; Region: PhoH; pfam02562 279808003847 metal-binding heat shock protein; Provisional; Region: PRK00016 279808003848 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 279808003849 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 279808003850 active site 279808003851 catalytic motif [active] 279808003852 Zn binding site [ion binding]; other site 279808003853 GTPase Era; Reviewed; Region: era; PRK00089 279808003854 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 279808003855 G1 box; other site 279808003856 GTP/Mg2+ binding site [chemical binding]; other site 279808003857 Switch I region; other site 279808003858 G2 box; other site 279808003859 Switch II region; other site 279808003860 G3 box; other site 279808003861 G4 box; other site 279808003862 G5 box; other site 279808003863 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 279808003864 Recombination protein O N terminal; Region: RecO_N; pfam11967 279808003865 DNA repair protein RecO; Region: reco; TIGR00613 279808003866 Recombination protein O C terminal; Region: RecO_C; pfam02565 279808003867 glycyl-tRNA synthetase; Provisional; Region: PRK04173 279808003868 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 279808003869 motif 1; other site 279808003870 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 279808003871 active site 279808003872 motif 2; other site 279808003873 motif 3; other site 279808003874 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 279808003875 anticodon binding site; other site 279808003876 FOG: CBS domain [General function prediction only]; Region: COG0517 279808003877 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 279808003878 PEP synthetase regulatory protein; Provisional; Region: PRK05339 279808003879 DNA primase, catalytic core; Region: dnaG; TIGR01391 279808003880 CHC2 zinc finger; Region: zf-CHC2; pfam01807 279808003881 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 279808003882 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 279808003883 active site 279808003884 metal binding site [ion binding]; metal-binding site 279808003885 interdomain interaction site; other site 279808003886 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 279808003887 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 279808003888 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 279808003889 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279808003890 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 279808003891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279808003892 DNA binding residues [nucleotide binding] 279808003893 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 279808003894 Family of unknown function (DUF633); Region: DUF633; pfam04816 279808003895 Uncharacterized conserved protein [Function unknown]; Region: COG0327 279808003896 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 279808003897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 279808003898 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 279808003899 Uncharacterized conserved protein [Function unknown]; Region: COG0327 279808003900 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 279808003901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 279808003902 ATP binding site [chemical binding]; other site 279808003903 putative Mg++ binding site [ion binding]; other site 279808003904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279808003905 nucleotide binding region [chemical binding]; other site 279808003906 ATP-binding site [chemical binding]; other site 279808003907 endonuclease IV; Provisional; Region: PRK01060 279808003908 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 279808003909 AP (apurinic/apyrimidinic) site pocket; other site 279808003910 DNA interaction; other site 279808003911 Metal-binding active site; metal-binding site 279808003912 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 279808003913 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 279808003914 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 279808003915 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279808003916 ABC-ATPase subunit interface; other site 279808003917 dimer interface [polypeptide binding]; other site 279808003918 putative PBP binding regions; other site 279808003919 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279808003920 metal binding site 2 [ion binding]; metal-binding site 279808003921 putative DNA binding helix; other site 279808003922 metal binding site 1 [ion binding]; metal-binding site 279808003923 dimer interface [polypeptide binding]; other site 279808003924 structural Zn2+ binding site [ion binding]; other site 279808003925 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 279808003926 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 279808003927 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 279808003928 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279808003929 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279808003930 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279808003931 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279808003932 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 279808003933 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 279808003934 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 279808003935 Rhomboid family; Region: Rhomboid; pfam01694 279808003936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 279808003937 TPR motif; other site 279808003938 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 279808003939 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 279808003940 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 279808003941 nucleotide binding site [chemical binding]; other site 279808003942 Uncharacterized conserved protein [Function unknown]; Region: COG0011 279808003943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279808003944 Type II/IV secretion system protein; Region: T2SE; pfam00437 279808003945 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 279808003946 Walker A motif; other site 279808003947 ATP binding site [chemical binding]; other site 279808003948 Walker B motif; other site 279808003949 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 279808003950 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 279808003951 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 279808003952 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 279808003953 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 279808003954 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 279808003955 ADP binding site [chemical binding]; other site 279808003956 magnesium binding site [ion binding]; other site 279808003957 putative shikimate binding site; other site 279808003958 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 279808003959 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 279808003960 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 279808003961 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 279808003962 tetramer interface [polypeptide binding]; other site 279808003963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808003964 catalytic residue [active] 279808003965 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 279808003966 tetramer interface [polypeptide binding]; other site 279808003967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808003968 catalytic residue [active] 279808003969 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 279808003970 active site residue [active] 279808003971 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 279808003972 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 279808003973 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 279808003974 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 279808003975 active site 279808003976 elongation factor P; Validated; Region: PRK00529 279808003977 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 279808003978 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 279808003979 RNA binding site [nucleotide binding]; other site 279808003980 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 279808003981 RNA binding site [nucleotide binding]; other site 279808003982 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 279808003983 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279808003984 carboxyltransferase (CT) interaction site; other site 279808003985 biotinylation site [posttranslational modification]; other site 279808003986 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 279808003987 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279808003988 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 279808003989 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 279808003990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 279808003991 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 279808003992 putative RNA binding site [nucleotide binding]; other site 279808003993 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 279808003994 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 279808003995 generic binding surface II; other site 279808003996 generic binding surface I; other site 279808003997 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 279808003998 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 279808003999 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 279808004000 substrate binding pocket [chemical binding]; other site 279808004001 chain length determination region; other site 279808004002 substrate-Mg2+ binding site; other site 279808004003 catalytic residues [active] 279808004004 aspartate-rich region 1; other site 279808004005 active site lid residues [active] 279808004006 aspartate-rich region 2; other site 279808004007 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 279808004008 arginine repressor; Provisional; Region: PRK04280 279808004009 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 279808004010 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 279808004011 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 279808004012 Walker A/P-loop; other site 279808004013 ATP binding site [chemical binding]; other site 279808004014 Q-loop/lid; other site 279808004015 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 279808004016 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 279808004017 ABC transporter signature motif; other site 279808004018 Walker B; other site 279808004019 D-loop; other site 279808004020 H-loop/switch region; other site 279808004021 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 279808004022 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 279808004023 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808004024 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279808004025 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 279808004026 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 279808004027 tetramer interface [polypeptide binding]; other site 279808004028 TPP-binding site [chemical binding]; other site 279808004029 heterodimer interface [polypeptide binding]; other site 279808004030 phosphorylation loop region [posttranslational modification] 279808004031 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 279808004032 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 279808004033 alpha subunit interface [polypeptide binding]; other site 279808004034 TPP binding site [chemical binding]; other site 279808004035 heterodimer interface [polypeptide binding]; other site 279808004036 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279808004037 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279808004038 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 279808004039 E3 interaction surface; other site 279808004040 lipoyl attachment site [posttranslational modification]; other site 279808004041 e3 binding domain; Region: E3_binding; pfam02817 279808004042 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 279808004043 Disulphide isomerase; Region: Disulph_isomer; pfam06491 279808004044 Predicted membrane protein [Function unknown]; Region: COG4129 279808004045 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 279808004046 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 279808004047 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808004048 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 279808004049 peptidase T-like protein; Region: PepT-like; TIGR01883 279808004050 metal binding site [ion binding]; metal-binding site 279808004051 putative dimer interface [polypeptide binding]; other site 279808004052 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 279808004053 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 279808004054 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 279808004055 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 279808004056 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 279808004057 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 279808004058 putative dimerization interface [polypeptide binding]; other site 279808004059 putative ligand binding site [chemical binding]; other site 279808004060 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 279808004061 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 279808004062 Ca binding site [ion binding]; other site 279808004063 active site 279808004064 catalytic site [active] 279808004065 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279808004066 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 279808004067 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 279808004068 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 279808004069 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 279808004070 ribonuclease Z; Region: RNase_Z; TIGR02651 279808004071 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 279808004072 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 279808004073 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 279808004074 classical (c) SDRs; Region: SDR_c; cd05233 279808004075 NAD(P) binding site [chemical binding]; other site 279808004076 active site 279808004077 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 279808004078 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279808004079 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279808004080 active site 279808004081 catalytic tetrad [active] 279808004082 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 279808004083 dimer interface [polypeptide binding]; other site 279808004084 ADP-ribose binding site [chemical binding]; other site 279808004085 active site 279808004086 nudix motif; other site 279808004087 metal binding site [ion binding]; metal-binding site 279808004088 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 279808004089 metal binding site 2 [ion binding]; metal-binding site 279808004090 putative DNA binding helix; other site 279808004091 metal binding site 1 [ion binding]; metal-binding site 279808004092 dimer interface [polypeptide binding]; other site 279808004093 structural Zn2+ binding site [ion binding]; other site 279808004094 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 279808004095 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 279808004096 active site 279808004097 Int/Topo IB signature motif; other site 279808004098 Domain of unknown function (DUF309); Region: DUF309; pfam03745 279808004099 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 279808004100 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 279808004101 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 279808004102 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279808004103 RNA binding surface [nucleotide binding]; other site 279808004104 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 279808004105 active site 279808004106 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808004108 active site 279808004109 phosphorylation site [posttranslational modification] 279808004110 intermolecular recognition site; other site 279808004111 dimerization interface [polypeptide binding]; other site 279808004112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279808004113 DNA binding site [nucleotide binding] 279808004114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 279808004115 dimerization interface [polypeptide binding]; other site 279808004116 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 279808004117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279808004118 dimer interface [polypeptide binding]; other site 279808004119 phosphorylation site [posttranslational modification] 279808004120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808004121 ATP binding site [chemical binding]; other site 279808004122 Mg2+ binding site [ion binding]; other site 279808004123 G-X-G motif; other site 279808004124 Predicted membrane protein [Function unknown]; Region: COG3601 279808004125 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 279808004126 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 279808004127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 279808004128 DEAD-like helicases superfamily; Region: DEXDc; smart00487 279808004129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279808004130 ATP binding site [chemical binding]; other site 279808004131 putative Mg++ binding site [ion binding]; other site 279808004132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279808004133 nucleotide binding region [chemical binding]; other site 279808004134 ATP-binding site [chemical binding]; other site 279808004135 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279808004136 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 279808004137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 279808004138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808004139 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 279808004140 active site 279808004141 homotetramer interface [polypeptide binding]; other site 279808004142 homodimer interface [polypeptide binding]; other site 279808004143 cytidylate kinase; Provisional; Region: cmk; PRK00023 279808004144 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 279808004145 CMP-binding site; other site 279808004146 The sites determining sugar specificity; other site 279808004147 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 279808004148 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 279808004149 RNA binding site [nucleotide binding]; other site 279808004150 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 279808004151 RNA binding site [nucleotide binding]; other site 279808004152 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 279808004153 RNA binding site [nucleotide binding]; other site 279808004154 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 279808004155 RNA binding site [nucleotide binding]; other site 279808004156 GTP-binding protein Der; Reviewed; Region: PRK00093 279808004157 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 279808004158 G1 box; other site 279808004159 GTP/Mg2+ binding site [chemical binding]; other site 279808004160 Switch I region; other site 279808004161 G2 box; other site 279808004162 Switch II region; other site 279808004163 G3 box; other site 279808004164 G4 box; other site 279808004165 G5 box; other site 279808004166 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 279808004167 G1 box; other site 279808004168 GTP/Mg2+ binding site [chemical binding]; other site 279808004169 Switch I region; other site 279808004170 G2 box; other site 279808004171 G3 box; other site 279808004172 Switch II region; other site 279808004173 G4 box; other site 279808004174 G5 box; other site 279808004175 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 279808004176 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 279808004177 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 279808004178 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 279808004179 IHF dimer interface [polypeptide binding]; other site 279808004180 IHF - DNA interface [nucleotide binding]; other site 279808004181 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808004182 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808004183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808004184 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808004185 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808004186 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 279808004187 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 279808004188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808004189 S-adenosylmethionine binding site [chemical binding]; other site 279808004190 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 279808004191 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 279808004192 substrate binding pocket [chemical binding]; other site 279808004193 chain length determination region; other site 279808004194 substrate-Mg2+ binding site; other site 279808004195 catalytic residues [active] 279808004196 aspartate-rich region 1; other site 279808004197 active site lid residues [active] 279808004198 aspartate-rich region 2; other site 279808004199 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 279808004200 active site 279808004201 multimer interface [polypeptide binding]; other site 279808004202 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 279808004203 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 279808004204 Tetramer interface [polypeptide binding]; other site 279808004205 active site 279808004206 FMN-binding site [chemical binding]; other site 279808004207 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 279808004208 active site 279808004209 dimer interface [polypeptide binding]; other site 279808004210 metal binding site [ion binding]; metal-binding site 279808004211 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 279808004212 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 279808004213 hinge; other site 279808004214 active site 279808004215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279808004216 TPR motif; other site 279808004217 binding surface 279808004218 UPF0302 domain; Region: UPF0302; pfam08864 279808004219 Uncharacterized conserved protein [Function unknown]; Region: COG5582 279808004220 IDEAL domain; Region: IDEAL; pfam08858 279808004221 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 279808004222 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 279808004223 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 279808004224 homodimer interface [polypeptide binding]; other site 279808004225 metal binding site [ion binding]; metal-binding site 279808004226 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 279808004227 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 279808004228 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 279808004229 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 279808004230 active site 279808004231 NTP binding site [chemical binding]; other site 279808004232 metal binding triad [ion binding]; metal-binding site 279808004233 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 279808004234 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 279808004235 Biotin operon repressor [Transcription]; Region: BirA; COG1654 279808004236 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 279808004237 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 279808004238 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 279808004239 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 279808004240 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 279808004241 active site 279808004242 catalytic site [active] 279808004243 substrate binding site [chemical binding]; other site 279808004244 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 279808004245 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 279808004246 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 279808004247 putative dimer interface [polypeptide binding]; other site 279808004248 putative anticodon binding site; other site 279808004249 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 279808004250 homodimer interface [polypeptide binding]; other site 279808004251 motif 1; other site 279808004252 motif 2; other site 279808004253 active site 279808004254 motif 3; other site 279808004255 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 279808004256 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 279808004257 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 279808004258 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 279808004259 minor groove reading motif; other site 279808004260 helix-hairpin-helix signature motif; other site 279808004261 substrate binding pocket [chemical binding]; other site 279808004262 active site 279808004263 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 279808004264 Transglycosylase; Region: Transgly; pfam00912 279808004265 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 279808004266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 279808004267 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 279808004268 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 279808004269 hypothetical protein; Provisional; Region: PRK13660 279808004270 cell division protein GpsB; Provisional; Region: PRK14127 279808004271 DivIVA domain; Region: DivI1A_domain; TIGR03544 279808004272 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 279808004273 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 279808004274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 279808004275 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 279808004276 NADH(P)-binding; Region: NAD_binding_10; pfam13460 279808004277 putative NAD(P) binding site [chemical binding]; other site 279808004278 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 279808004279 Dynamin family; Region: Dynamin_N; pfam00350 279808004280 G1 box; other site 279808004281 GTP/Mg2+ binding site [chemical binding]; other site 279808004282 G2 box; other site 279808004283 Switch I region; other site 279808004284 G3 box; other site 279808004285 Switch II region; other site 279808004286 G4 box; other site 279808004287 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 279808004288 Dynamin family; Region: Dynamin_N; pfam00350 279808004289 G1 box; other site 279808004290 GTP/Mg2+ binding site [chemical binding]; other site 279808004291 G2 box; other site 279808004292 Switch I region; other site 279808004293 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 279808004294 G3 box; other site 279808004295 Switch II region; other site 279808004296 GTP/Mg2+ binding site [chemical binding]; other site 279808004297 G4 box; other site 279808004298 G5 box; other site 279808004299 5'-3' exonuclease; Region: 53EXOc; smart00475 279808004300 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 279808004301 active site 279808004302 metal binding site 1 [ion binding]; metal-binding site 279808004303 putative 5' ssDNA interaction site; other site 279808004304 metal binding site 3; metal-binding site 279808004305 metal binding site 2 [ion binding]; metal-binding site 279808004306 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 279808004307 putative DNA binding site [nucleotide binding]; other site 279808004308 putative metal binding site [ion binding]; other site 279808004309 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 279808004310 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 279808004311 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 279808004312 RNA/DNA hybrid binding site [nucleotide binding]; other site 279808004313 active site 279808004314 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 279808004315 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 279808004316 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 279808004317 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 279808004318 Virulence factor; Region: Virulence_fact; pfam13769 279808004319 HEAT repeats; Region: HEAT_2; pfam13646 279808004320 HEAT repeat; Region: HEAT; pfam02985 279808004321 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 279808004322 thymidylate synthase; Region: thym_sym; TIGR03284 279808004323 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 279808004324 dimerization interface [polypeptide binding]; other site 279808004325 active site 279808004326 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 279808004327 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 279808004328 folate binding site [chemical binding]; other site 279808004329 NADP+ binding site [chemical binding]; other site 279808004330 EDD domain protein, DegV family; Region: DegV; TIGR00762 279808004331 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 279808004332 methionine sulfoxide reductase A; Provisional; Region: PRK13014 279808004333 methionine sulfoxide reductase B; Provisional; Region: PRK00222 279808004334 SelR domain; Region: SelR; pfam01641 279808004335 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 279808004336 HPr interaction site; other site 279808004337 glycerol kinase (GK) interaction site [polypeptide binding]; other site 279808004338 active site 279808004339 phosphorylation site [posttranslational modification] 279808004340 hypothetical protein; Provisional; Region: PRK13672 279808004341 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 279808004342 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 279808004343 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 279808004344 protein binding site [polypeptide binding]; other site 279808004345 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 279808004346 Catalytic dyad [active] 279808004347 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 279808004348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 279808004349 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279808004350 Coenzyme A binding pocket [chemical binding]; other site 279808004351 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 279808004352 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 279808004353 active site 279808004354 homodimer interface [polypeptide binding]; other site 279808004355 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 279808004356 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 279808004357 active site 279808004358 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808004359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808004360 active site 279808004361 phosphorylation site [posttranslational modification] 279808004362 intermolecular recognition site; other site 279808004363 dimerization interface [polypeptide binding]; other site 279808004364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279808004365 DNA binding site [nucleotide binding] 279808004366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279808004367 HAMP domain; Region: HAMP; pfam00672 279808004368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 279808004369 dimer interface [polypeptide binding]; other site 279808004370 phosphorylation site [posttranslational modification] 279808004371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808004372 ATP binding site [chemical binding]; other site 279808004373 Mg2+ binding site [ion binding]; other site 279808004374 G-X-G motif; other site 279808004375 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 279808004376 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 279808004377 TPP-binding site [chemical binding]; other site 279808004378 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 279808004379 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 279808004380 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279808004381 E3 interaction surface; other site 279808004382 lipoyl attachment site [posttranslational modification]; other site 279808004383 e3 binding domain; Region: E3_binding; pfam02817 279808004384 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 279808004385 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808004386 MULE transposase domain; Region: MULE; pfam10551 279808004387 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279808004388 active site 279808004389 metal binding site [ion binding]; metal-binding site 279808004390 MoxR-like ATPases [General function prediction only]; Region: COG0714 279808004391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808004392 Walker A motif; other site 279808004393 ATP binding site [chemical binding]; other site 279808004394 Walker B motif; other site 279808004395 arginine finger; other site 279808004396 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 279808004397 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 279808004398 metal ion-dependent adhesion site (MIDAS); other site 279808004399 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 279808004400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808004401 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808004402 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808004403 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 279808004404 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 279808004405 acylphosphatase; Provisional; Region: PRK14431 279808004406 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 279808004407 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 279808004408 DNA-binding site [nucleotide binding]; DNA binding site 279808004409 RNA-binding motif; other site 279808004410 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808004411 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808004412 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 279808004413 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 279808004414 active site 279808004415 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279808004416 substrate binding site [chemical binding]; other site 279808004417 catalytic residues [active] 279808004418 dimer interface [polypeptide binding]; other site 279808004419 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 279808004420 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 279808004421 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279808004422 catalytic residue [active] 279808004423 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279808004424 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 279808004425 metal binding site [ion binding]; metal-binding site 279808004426 dimer interface [polypeptide binding]; other site 279808004427 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 279808004428 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 279808004429 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 279808004430 trimer interface [polypeptide binding]; other site 279808004431 active site 279808004432 substrate binding site [chemical binding]; other site 279808004433 CoA binding site [chemical binding]; other site 279808004434 dihydrodipicolinate reductase; Provisional; Region: PRK00048 279808004435 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 279808004436 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 279808004437 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 279808004438 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 279808004439 dimer interface [polypeptide binding]; other site 279808004440 active site 279808004441 catalytic residue [active] 279808004442 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 279808004443 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 279808004444 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 279808004445 aspartate kinase; Reviewed; Region: PRK06635 279808004446 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 279808004447 putative nucleotide binding site [chemical binding]; other site 279808004448 putative catalytic residues [active] 279808004449 putative Mg ion binding site [ion binding]; other site 279808004450 putative aspartate binding site [chemical binding]; other site 279808004451 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 279808004452 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 279808004453 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 279808004454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808004455 Walker A/P-loop; other site 279808004456 ATP binding site [chemical binding]; other site 279808004457 Q-loop/lid; other site 279808004458 ABC transporter signature motif; other site 279808004459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808004460 Walker B; other site 279808004461 D-loop; other site 279808004462 H-loop/switch region; other site 279808004463 ABC transporter; Region: ABC_tran_2; pfam12848 279808004464 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808004465 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 279808004466 S1 domain; Region: S1_2; pfam13509 279808004467 PBP superfamily domain; Region: PBP_like_2; cl17296 279808004468 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 279808004469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808004470 dimer interface [polypeptide binding]; other site 279808004471 conserved gate region; other site 279808004472 putative PBP binding loops; other site 279808004473 ABC-ATPase subunit interface; other site 279808004474 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 279808004475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808004476 dimer interface [polypeptide binding]; other site 279808004477 conserved gate region; other site 279808004478 ABC-ATPase subunit interface; other site 279808004479 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 279808004480 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 279808004481 Walker A/P-loop; other site 279808004482 ATP binding site [chemical binding]; other site 279808004483 Q-loop/lid; other site 279808004484 ABC transporter signature motif; other site 279808004485 Walker B; other site 279808004486 D-loop; other site 279808004487 H-loop/switch region; other site 279808004488 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 279808004489 PhoU domain; Region: PhoU; pfam01895 279808004490 PhoU domain; Region: PhoU; pfam01895 279808004491 oligoendopeptidase F; Region: pepF; TIGR00181 279808004492 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 279808004493 active site 279808004494 Zn binding site [ion binding]; other site 279808004495 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 279808004496 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 279808004497 intersubunit interface [polypeptide binding]; other site 279808004498 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 279808004499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 279808004500 active site 279808004501 motif I; other site 279808004502 motif II; other site 279808004503 FemAB family; Region: FemAB; pfam02388 279808004504 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 279808004505 FemAB family; Region: FemAB; pfam02388 279808004506 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 279808004507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808004508 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808004509 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808004510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 279808004511 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 279808004512 substrate binding site [chemical binding]; other site 279808004513 active site 279808004514 catalytic residues [active] 279808004515 heterodimer interface [polypeptide binding]; other site 279808004516 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 279808004517 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 279808004518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808004519 catalytic residue [active] 279808004520 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 279808004521 active site 279808004522 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 279808004523 active site 279808004524 ribulose/triose binding site [chemical binding]; other site 279808004525 phosphate binding site [ion binding]; other site 279808004526 substrate (anthranilate) binding pocket [chemical binding]; other site 279808004527 product (indole) binding pocket [chemical binding]; other site 279808004528 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 279808004529 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 279808004530 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 279808004531 Glutamine amidotransferase class-I; Region: GATase; pfam00117 279808004532 glutamine binding [chemical binding]; other site 279808004533 catalytic triad [active] 279808004534 anthranilate synthase component I; Provisional; Region: PRK13567 279808004535 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 279808004536 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 279808004537 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 279808004538 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 279808004539 putative oligomer interface [polypeptide binding]; other site 279808004540 putative active site [active] 279808004541 metal binding site [ion binding]; metal-binding site 279808004542 prephenate dehydrogenase; Validated; Region: PRK06545 279808004543 prephenate dehydrogenase; Validated; Region: PRK08507 279808004544 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 279808004545 DNA polymerase IV; Reviewed; Region: PRK03103 279808004546 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 279808004547 active site 279808004548 DNA binding site [nucleotide binding] 279808004549 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 279808004550 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 279808004551 active site 1 [active] 279808004552 dimer interface [polypeptide binding]; other site 279808004553 hexamer interface [polypeptide binding]; other site 279808004554 active site 2 [active] 279808004555 Transcriptional regulator [Transcription]; Region: LytR; COG1316 279808004556 methionine sulfoxide reductase A; Provisional; Region: PRK14054 279808004557 Predicted integral membrane protein [Function unknown]; Region: COG0392 279808004558 Uncharacterized conserved protein [Function unknown]; Region: COG2898 279808004559 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 279808004560 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 279808004561 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279808004562 CAT RNA binding domain; Region: CAT_RBD; smart01061 279808004563 transcriptional antiterminator BglG; Provisional; Region: PRK09772 279808004564 PRD domain; Region: PRD; pfam00874 279808004565 PRD domain; Region: PRD; pfam00874 279808004566 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 279808004567 amino acid carrier protein; Region: agcS; TIGR00835 279808004568 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 279808004569 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 279808004570 CAP-like domain; other site 279808004571 active site 279808004572 primary dimer interface [polypeptide binding]; other site 279808004573 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279808004574 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 279808004575 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 279808004576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808004577 ATP binding site [chemical binding]; other site 279808004578 Mg2+ binding site [ion binding]; other site 279808004579 G-X-G motif; other site 279808004580 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 279808004581 anchoring element; other site 279808004582 dimer interface [polypeptide binding]; other site 279808004583 ATP binding site [chemical binding]; other site 279808004584 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 279808004585 active site 279808004586 putative metal-binding site [ion binding]; other site 279808004587 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 279808004588 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 279808004589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 279808004590 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 279808004591 active site 279808004592 aconitate hydratase; Validated; Region: PRK09277 279808004593 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 279808004594 substrate binding site [chemical binding]; other site 279808004595 ligand binding site [chemical binding]; other site 279808004596 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 279808004597 substrate binding site [chemical binding]; other site 279808004598 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 279808004599 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 279808004600 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 279808004601 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 279808004602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808004603 Walker A/P-loop; other site 279808004604 ATP binding site [chemical binding]; other site 279808004605 Q-loop/lid; other site 279808004606 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 279808004607 ABC transporter signature motif; other site 279808004608 Walker B; other site 279808004609 D-loop; other site 279808004610 H-loop/switch region; other site 279808004611 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 279808004612 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279808004613 active site 279808004614 metal binding site [ion binding]; metal-binding site 279808004615 DNA binding site [nucleotide binding] 279808004616 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 279808004617 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 279808004618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 279808004619 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 279808004620 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 279808004621 TPP-binding site [chemical binding]; other site 279808004622 dimer interface [polypeptide binding]; other site 279808004623 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 279808004624 PYR/PP interface [polypeptide binding]; other site 279808004625 dimer interface [polypeptide binding]; other site 279808004626 TPP binding site [chemical binding]; other site 279808004627 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279808004628 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 279808004629 LexA repressor; Validated; Region: PRK00215 279808004630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279808004631 putative DNA binding site [nucleotide binding]; other site 279808004632 putative Zn2+ binding site [ion binding]; other site 279808004633 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 279808004634 Catalytic site [active] 279808004635 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 279808004636 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 279808004637 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 279808004638 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 279808004639 active site 279808004640 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 279808004641 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 279808004642 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 279808004643 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 279808004644 tetramer interface [polypeptide binding]; other site 279808004645 heme binding pocket [chemical binding]; other site 279808004646 NADPH binding site [chemical binding]; other site 279808004647 lysine transporter; Provisional; Region: PRK10836 279808004648 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279808004649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808004650 active site 279808004651 motif I; other site 279808004652 motif II; other site 279808004653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808004654 homoserine kinase; Provisional; Region: PRK01212 279808004655 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 279808004656 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 279808004657 threonine synthase; Reviewed; Region: PRK06721 279808004658 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 279808004659 homodimer interface [polypeptide binding]; other site 279808004660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808004661 catalytic residue [active] 279808004662 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 279808004663 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 279808004664 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 279808004665 aspartate kinase; Reviewed; Region: PRK09034 279808004666 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 279808004667 putative catalytic residues [active] 279808004668 putative nucleotide binding site [chemical binding]; other site 279808004669 putative aspartate binding site [chemical binding]; other site 279808004670 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 279808004671 allosteric regulatory residue; other site 279808004672 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 279808004673 Staphylococcal nuclease homologues; Region: SNc; smart00318 279808004674 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 279808004675 Catalytic site; other site 279808004676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 279808004677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808004678 active site 279808004679 phosphorylation site [posttranslational modification] 279808004680 intermolecular recognition site; other site 279808004681 dimerization interface [polypeptide binding]; other site 279808004682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 279808004683 DNA binding residues [nucleotide binding] 279808004684 dimerization interface [polypeptide binding]; other site 279808004685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 279808004686 Histidine kinase; Region: HisKA_3; pfam07730 279808004687 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 279808004688 ATP binding site [chemical binding]; other site 279808004689 Mg2+ binding site [ion binding]; other site 279808004690 G-X-G motif; other site 279808004691 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 279808004692 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 279808004693 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 279808004694 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 279808004695 Walker A/P-loop; other site 279808004696 ATP binding site [chemical binding]; other site 279808004697 Q-loop/lid; other site 279808004698 ABC transporter signature motif; other site 279808004699 Walker B; other site 279808004700 D-loop; other site 279808004701 H-loop/switch region; other site 279808004702 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 279808004703 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 279808004704 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 279808004705 putative active site [active] 279808004706 catalytic site [active] 279808004707 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 279808004708 putative active site [active] 279808004709 catalytic site [active] 279808004710 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 279808004711 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279808004712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279808004713 catalytic residue [active] 279808004714 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 279808004715 SPRY domain; Region: SPRY; cl02614 279808004716 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 279808004717 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 279808004718 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 279808004719 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 279808004720 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 279808004721 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279808004722 DNA binding residues [nucleotide binding] 279808004723 putative dimer interface [polypeptide binding]; other site 279808004724 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 279808004725 Aluminium resistance protein; Region: Alum_res; pfam06838 279808004726 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 279808004727 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 279808004728 HflX GTPase family; Region: HflX; cd01878 279808004729 G1 box; other site 279808004730 GTP/Mg2+ binding site [chemical binding]; other site 279808004731 Switch I region; other site 279808004732 G2 box; other site 279808004733 G3 box; other site 279808004734 Switch II region; other site 279808004735 G4 box; other site 279808004736 G5 box; other site 279808004737 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 279808004738 catalytic residues [active] 279808004739 dimer interface [polypeptide binding]; other site 279808004740 bacterial Hfq-like; Region: Hfq; cd01716 279808004741 hexamer interface [polypeptide binding]; other site 279808004742 Sm1 motif; other site 279808004743 RNA binding site [nucleotide binding]; other site 279808004744 Sm2 motif; other site 279808004745 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 279808004746 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 279808004747 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 279808004748 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279808004749 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 279808004750 glycerol kinase; Provisional; Region: glpK; PRK00047 279808004751 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 279808004752 N- and C-terminal domain interface [polypeptide binding]; other site 279808004753 active site 279808004754 MgATP binding site [chemical binding]; other site 279808004755 catalytic site [active] 279808004756 metal binding site [ion binding]; metal-binding site 279808004757 glycerol binding site [chemical binding]; other site 279808004758 homotetramer interface [polypeptide binding]; other site 279808004759 homodimer interface [polypeptide binding]; other site 279808004760 FBP binding site [chemical binding]; other site 279808004761 protein IIAGlc interface [polypeptide binding]; other site 279808004762 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808004763 MULE transposase domain; Region: MULE; pfam10551 279808004764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 279808004765 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 279808004766 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279808004767 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 279808004768 Phosphotransferase enzyme family; Region: APH; pfam01636 279808004769 active site 279808004770 ATP binding site [chemical binding]; other site 279808004771 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 279808004772 substrate binding site [chemical binding]; other site 279808004773 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279808004774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808004775 Coenzyme A binding pocket [chemical binding]; other site 279808004776 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808004777 MULE transposase domain; Region: MULE; pfam10551 279808004778 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 279808004779 amphipathic channel; other site 279808004780 Asn-Pro-Ala signature motifs; other site 279808004781 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 279808004782 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 279808004783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808004784 ATP binding site [chemical binding]; other site 279808004785 Mg2+ binding site [ion binding]; other site 279808004786 G-X-G motif; other site 279808004787 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 279808004788 ATP binding site [chemical binding]; other site 279808004789 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 279808004790 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 279808004791 MutS domain I; Region: MutS_I; pfam01624 279808004792 MutS domain II; Region: MutS_II; pfam05188 279808004793 MutS domain III; Region: MutS_III; pfam05192 279808004794 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 279808004795 Walker A/P-loop; other site 279808004796 ATP binding site [chemical binding]; other site 279808004797 Q-loop/lid; other site 279808004798 ABC transporter signature motif; other site 279808004799 Walker B; other site 279808004800 D-loop; other site 279808004801 H-loop/switch region; other site 279808004802 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 279808004803 Predicted membrane protein [Function unknown]; Region: COG4550 279808004804 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 279808004805 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 279808004806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279808004807 FeS/SAM binding site; other site 279808004808 TRAM domain; Region: TRAM; pfam01938 279808004809 Uncharacterized conserved protein [Function unknown]; Region: COG0011 279808004810 Protein of unknown function (DUF867); Region: DUF867; pfam05908 279808004811 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 279808004812 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 279808004813 TPP-binding site [chemical binding]; other site 279808004814 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 279808004815 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 279808004816 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 279808004817 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 279808004818 dimer interface [polypeptide binding]; other site 279808004819 PYR/PP interface [polypeptide binding]; other site 279808004820 TPP binding site [chemical binding]; other site 279808004821 substrate binding site [chemical binding]; other site 279808004822 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279808004823 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 279808004824 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 279808004825 putative active site [active] 279808004826 metal binding site [ion binding]; metal-binding site 279808004827 homodimer binding site [polypeptide binding]; other site 279808004828 phosphodiesterase; Provisional; Region: PRK12704 279808004829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279808004830 Zn2+ binding site [ion binding]; other site 279808004831 Mg2+ binding site [ion binding]; other site 279808004832 recombinase A; Provisional; Region: recA; PRK09354 279808004833 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 279808004834 hexamer interface [polypeptide binding]; other site 279808004835 Walker A motif; other site 279808004836 ATP binding site [chemical binding]; other site 279808004837 Walker B motif; other site 279808004838 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 279808004839 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 279808004840 putative MPT binding site; other site 279808004841 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 279808004842 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 279808004843 Helix-turn-helix domain; Region: HTH_25; pfam13413 279808004844 non-specific DNA binding site [nucleotide binding]; other site 279808004845 salt bridge; other site 279808004846 sequence-specific DNA binding site [nucleotide binding]; other site 279808004847 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 279808004848 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 279808004849 classical (c) SDRs; Region: SDR_c; cd05233 279808004850 NAD(P) binding site [chemical binding]; other site 279808004851 active site 279808004852 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 279808004853 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 279808004854 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 279808004855 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 279808004856 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 279808004857 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 279808004858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279808004859 DNA-binding site [nucleotide binding]; DNA binding site 279808004860 UTRA domain; Region: UTRA; pfam07702 279808004861 ER lumen protein retaining receptor; Region: ER_lumen_recept; cl02155 279808004862 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 279808004863 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 279808004864 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 279808004865 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 279808004866 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 279808004867 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 279808004868 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 279808004869 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 279808004870 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 279808004871 RNase E interface [polypeptide binding]; other site 279808004872 trimer interface [polypeptide binding]; other site 279808004873 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 279808004874 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 279808004875 RNase E interface [polypeptide binding]; other site 279808004876 trimer interface [polypeptide binding]; other site 279808004877 active site 279808004878 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 279808004879 putative nucleic acid binding region [nucleotide binding]; other site 279808004880 G-X-X-G motif; other site 279808004881 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 279808004882 RNA binding site [nucleotide binding]; other site 279808004883 domain interface; other site 279808004884 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 279808004885 16S/18S rRNA binding site [nucleotide binding]; other site 279808004886 S13e-L30e interaction site [polypeptide binding]; other site 279808004887 25S rRNA binding site [nucleotide binding]; other site 279808004888 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 279808004889 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 279808004890 active site 279808004891 Riboflavin kinase; Region: Flavokinase; smart00904 279808004892 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 279808004893 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 279808004894 RNA binding site [nucleotide binding]; other site 279808004895 active site 279808004896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808004897 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808004898 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 279808004899 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 279808004900 translation initiation factor IF-2; Region: IF-2; TIGR00487 279808004901 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 279808004902 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 279808004903 G1 box; other site 279808004904 putative GEF interaction site [polypeptide binding]; other site 279808004905 GTP/Mg2+ binding site [chemical binding]; other site 279808004906 Switch I region; other site 279808004907 G2 box; other site 279808004908 G3 box; other site 279808004909 Switch II region; other site 279808004910 G4 box; other site 279808004911 G5 box; other site 279808004912 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 279808004913 Translation-initiation factor 2; Region: IF-2; pfam11987 279808004914 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 279808004915 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 279808004916 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 279808004917 putative RNA binding cleft [nucleotide binding]; other site 279808004918 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 279808004919 NusA N-terminal domain; Region: NusA_N; pfam08529 279808004920 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 279808004921 RNA binding site [nucleotide binding]; other site 279808004922 homodimer interface [polypeptide binding]; other site 279808004923 NusA-like KH domain; Region: KH_5; pfam13184 279808004924 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 279808004925 G-X-X-G motif; other site 279808004926 ribosome maturation protein RimP; Reviewed; Region: PRK00092 279808004927 Sm and related proteins; Region: Sm_like; cl00259 279808004928 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 279808004929 putative oligomer interface [polypeptide binding]; other site 279808004930 putative RNA binding site [nucleotide binding]; other site 279808004931 DNA polymerase III PolC; Validated; Region: polC; PRK00448 279808004932 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 279808004933 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 279808004934 generic binding surface II; other site 279808004935 generic binding surface I; other site 279808004936 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 279808004937 active site 279808004938 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 279808004939 active site 279808004940 catalytic site [active] 279808004941 substrate binding site [chemical binding]; other site 279808004942 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 279808004943 prolyl-tRNA synthetase; Provisional; Region: PRK09194 279808004944 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 279808004945 dimer interface [polypeptide binding]; other site 279808004946 motif 1; other site 279808004947 active site 279808004948 motif 2; other site 279808004949 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 279808004950 putative deacylase active site [active] 279808004951 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 279808004952 active site 279808004953 motif 3; other site 279808004954 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 279808004955 anticodon binding site; other site 279808004956 RIP metalloprotease RseP; Region: TIGR00054 279808004957 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 279808004958 active site 279808004959 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 279808004960 protein binding site [polypeptide binding]; other site 279808004961 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 279808004962 putative substrate binding region [chemical binding]; other site 279808004963 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 279808004964 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 279808004965 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 279808004966 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 279808004967 catalytic residue [active] 279808004968 putative FPP diphosphate binding site; other site 279808004969 putative FPP binding hydrophobic cleft; other site 279808004970 dimer interface [polypeptide binding]; other site 279808004971 putative IPP diphosphate binding site; other site 279808004972 ribosome recycling factor; Reviewed; Region: frr; PRK00083 279808004973 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 279808004974 hinge region; other site 279808004975 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 279808004976 putative nucleotide binding site [chemical binding]; other site 279808004977 uridine monophosphate binding site [chemical binding]; other site 279808004978 homohexameric interface [polypeptide binding]; other site 279808004979 elongation factor Ts; Provisional; Region: tsf; PRK09377 279808004980 UBA/TS-N domain; Region: UBA; pfam00627 279808004981 Elongation factor TS; Region: EF_TS; pfam00889 279808004982 Elongation factor TS; Region: EF_TS; pfam00889 279808004983 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 279808004984 rRNA interaction site [nucleotide binding]; other site 279808004985 S8 interaction site; other site 279808004986 putative laminin-1 binding site; other site 279808004987 transcriptional repressor CodY; Validated; Region: PRK04158 279808004988 CodY GAF-like domain; Region: CodY; pfam06018 279808004989 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 279808004990 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 279808004991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808004992 Walker A motif; other site 279808004993 ATP binding site [chemical binding]; other site 279808004994 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 279808004995 Walker B motif; other site 279808004996 arginine finger; other site 279808004997 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 279808004998 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 279808004999 active site 279808005000 HslU subunit interaction site [polypeptide binding]; other site 279808005001 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279808005002 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 279808005003 active site 279808005004 DNA binding site [nucleotide binding] 279808005005 Int/Topo IB signature motif; other site 279808005006 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 279808005007 Glucose inhibited division protein A; Region: GIDA; pfam01134 279808005008 DNA topoisomerase I; Validated; Region: PRK05582 279808005009 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 279808005010 active site 279808005011 interdomain interaction site; other site 279808005012 putative metal-binding site [ion binding]; other site 279808005013 nucleotide binding site [chemical binding]; other site 279808005014 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 279808005015 domain I; other site 279808005016 DNA binding groove [nucleotide binding] 279808005017 phosphate binding site [ion binding]; other site 279808005018 domain II; other site 279808005019 domain III; other site 279808005020 nucleotide binding site [chemical binding]; other site 279808005021 catalytic site [active] 279808005022 domain IV; other site 279808005023 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 279808005024 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 279808005025 DNA protecting protein DprA; Region: dprA; TIGR00732 279808005026 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 279808005027 FemAB family; Region: FemAB; pfam02388 279808005028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 279808005029 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 279808005030 CoA binding domain; Region: CoA_binding; pfam02629 279808005031 CoA-ligase; Region: Ligase_CoA; pfam00549 279808005032 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 279808005033 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 279808005034 CoA-ligase; Region: Ligase_CoA; pfam00549 279808005035 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 279808005036 RNA/DNA hybrid binding site [nucleotide binding]; other site 279808005037 active site 279808005038 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 279808005039 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 279808005040 GTP/Mg2+ binding site [chemical binding]; other site 279808005041 G4 box; other site 279808005042 G5 box; other site 279808005043 G1 box; other site 279808005044 Switch I region; other site 279808005045 G2 box; other site 279808005046 G3 box; other site 279808005047 Switch II region; other site 279808005048 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 279808005049 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 279808005050 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 279808005051 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 279808005052 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 279808005053 RimM N-terminal domain; Region: RimM; pfam01782 279808005054 PRC-barrel domain; Region: PRC; pfam05239 279808005055 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 279808005056 signal recognition particle protein; Provisional; Region: PRK10867 279808005057 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 279808005058 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 279808005059 P loop; other site 279808005060 GTP binding site [chemical binding]; other site 279808005061 Signal peptide binding domain; Region: SRP_SPB; pfam02978 279808005062 putative DNA-binding protein; Validated; Region: PRK00118 279808005063 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 279808005064 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 279808005065 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 279808005066 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 279808005067 P loop; other site 279808005068 GTP binding site [chemical binding]; other site 279808005069 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 279808005070 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 279808005071 Walker A/P-loop; other site 279808005072 ATP binding site [chemical binding]; other site 279808005073 Q-loop/lid; other site 279808005074 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 279808005075 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 279808005076 ABC transporter signature motif; other site 279808005077 Walker B; other site 279808005078 D-loop; other site 279808005079 H-loop/switch region; other site 279808005080 ribonuclease III; Reviewed; Region: rnc; PRK00102 279808005081 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 279808005082 dimerization interface [polypeptide binding]; other site 279808005083 active site 279808005084 metal binding site [ion binding]; metal-binding site 279808005085 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 279808005086 dsRNA binding site [nucleotide binding]; other site 279808005087 acyl carrier protein; Provisional; Region: acpP; PRK00982 279808005088 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 279808005089 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 279808005090 NAD(P) binding site [chemical binding]; other site 279808005091 homotetramer interface [polypeptide binding]; other site 279808005092 homodimer interface [polypeptide binding]; other site 279808005093 active site 279808005094 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 279808005095 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 279808005096 putative phosphate acyltransferase; Provisional; Region: PRK05331 279808005097 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 279808005098 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 279808005099 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 279808005100 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 279808005101 generic binding surface II; other site 279808005102 ssDNA binding site; other site 279808005103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279808005104 ATP binding site [chemical binding]; other site 279808005105 putative Mg++ binding site [ion binding]; other site 279808005106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279808005107 nucleotide binding region [chemical binding]; other site 279808005108 ATP-binding site [chemical binding]; other site 279808005109 Staphylococcal nuclease homologues; Region: SNc; smart00318 279808005110 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 279808005111 Catalytic site; other site 279808005112 Excalibur calcium-binding domain; Region: Excalibur; smart00894 279808005113 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 279808005114 DAK2 domain; Region: Dak2; pfam02734 279808005115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 279808005116 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 279808005117 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 279808005118 Thiamine pyrophosphokinase; Region: TPK; cd07995 279808005119 active site 279808005120 dimerization interface [polypeptide binding]; other site 279808005121 thiamine binding site [chemical binding]; other site 279808005122 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 279808005123 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 279808005124 substrate binding site [chemical binding]; other site 279808005125 hexamer interface [polypeptide binding]; other site 279808005126 metal binding site [ion binding]; metal-binding site 279808005127 GTPase RsgA; Reviewed; Region: PRK00098 279808005128 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 279808005129 RNA binding site [nucleotide binding]; other site 279808005130 homodimer interface [polypeptide binding]; other site 279808005131 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 279808005132 GTPase/Zn-binding domain interface [polypeptide binding]; other site 279808005133 GTP/Mg2+ binding site [chemical binding]; other site 279808005134 G4 box; other site 279808005135 G5 box; other site 279808005136 G1 box; other site 279808005137 Switch I region; other site 279808005138 G2 box; other site 279808005139 G3 box; other site 279808005140 Switch II region; other site 279808005141 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 279808005142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 279808005143 active site 279808005144 ATP binding site [chemical binding]; other site 279808005145 substrate binding site [chemical binding]; other site 279808005146 activation loop (A-loop); other site 279808005147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 279808005148 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 279808005149 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 279808005150 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 279808005151 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 279808005152 Protein phosphatase 2C; Region: PP2C; pfam00481 279808005153 active site 279808005154 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 279808005155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279808005156 FeS/SAM binding site; other site 279808005157 16S rRNA methyltransferase B; Provisional; Region: PRK14902 279808005158 NusB family; Region: NusB; pfam01029 279808005159 putative RNA binding site [nucleotide binding]; other site 279808005160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808005161 S-adenosylmethionine binding site [chemical binding]; other site 279808005162 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 279808005163 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 279808005164 putative active site [active] 279808005165 substrate binding site [chemical binding]; other site 279808005166 putative cosubstrate binding site; other site 279808005167 catalytic site [active] 279808005168 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 279808005169 substrate binding site [chemical binding]; other site 279808005170 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 279808005171 active site 279808005172 catalytic residues [active] 279808005173 metal binding site [ion binding]; metal-binding site 279808005174 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 279808005175 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 279808005176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279808005177 ATP binding site [chemical binding]; other site 279808005178 putative Mg++ binding site [ion binding]; other site 279808005179 helicase superfamily c-terminal domain; Region: HELICc; smart00490 279808005180 nucleotide binding region [chemical binding]; other site 279808005181 ATP-binding site [chemical binding]; other site 279808005182 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 279808005183 Flavoprotein; Region: Flavoprotein; pfam02441 279808005184 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 279808005185 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 279808005186 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 279808005187 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 279808005188 catalytic site [active] 279808005189 G-X2-G-X-G-K; other site 279808005190 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 279808005191 Domain of unknown function (DUF814); Region: DUF814; pfam05670 279808005192 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 279808005193 dimer interface [polypeptide binding]; other site 279808005194 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279808005195 active site 279808005196 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 279808005197 active site 279808005198 dimer interface [polypeptide binding]; other site 279808005199 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 279808005200 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279808005201 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 279808005202 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 279808005203 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279808005204 ATP-grasp domain; Region: ATP-grasp_4; cl17255 279808005205 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 279808005206 IMP binding site; other site 279808005207 dimer interface [polypeptide binding]; other site 279808005208 interdomain contacts; other site 279808005209 partial ornithine binding site; other site 279808005210 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 279808005211 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 279808005212 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 279808005213 catalytic site [active] 279808005214 subunit interface [polypeptide binding]; other site 279808005215 dihydroorotase; Validated; Region: pyrC; PRK09357 279808005216 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279808005217 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 279808005218 active site 279808005219 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 279808005220 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 279808005221 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 279808005222 uracil transporter; Provisional; Region: PRK10720 279808005223 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 279808005224 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 279808005225 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 279808005226 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279808005227 RNA binding surface [nucleotide binding]; other site 279808005228 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 279808005229 active site 279808005230 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 279808005231 Surface antigen [General function prediction only]; Region: COG3942 279808005232 CHAP domain; Region: CHAP; pfam05257 279808005233 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 279808005234 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279808005235 active site 279808005236 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 279808005237 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 279808005238 putative NAD(P) binding site [chemical binding]; other site 279808005239 putative active site [active] 279808005240 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 279808005241 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 279808005242 HIGH motif; other site 279808005243 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 279808005244 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 279808005245 active site 279808005246 KMSKS motif; other site 279808005247 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 279808005248 tRNA binding surface [nucleotide binding]; other site 279808005249 anticodon binding site; other site 279808005250 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 279808005251 DivIVA protein; Region: DivIVA; pfam05103 279808005252 DivIVA domain; Region: DivI1A_domain; TIGR03544 279808005253 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 279808005254 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279808005255 RNA binding surface [nucleotide binding]; other site 279808005256 YGGT family; Region: YGGT; pfam02325 279808005257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 279808005258 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 279808005259 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 279808005260 catalytic residue [active] 279808005261 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 279808005262 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 279808005263 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 279808005264 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 279808005265 nucleotide binding site [chemical binding]; other site 279808005266 SulA interaction site; other site 279808005267 cell division protein FtsA; Region: ftsA; TIGR01174 279808005268 Cell division protein FtsA; Region: FtsA; smart00842 279808005269 Cell division protein FtsA; Region: FtsA; pfam14450 279808005270 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 279808005271 Cell division protein FtsQ; Region: FtsQ; pfam03799 279808005272 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 279808005273 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 279808005274 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279808005275 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279808005276 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 279808005277 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 279808005278 Mg++ binding site [ion binding]; other site 279808005279 putative catalytic motif [active] 279808005280 putative substrate binding site [chemical binding]; other site 279808005281 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 279808005282 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 279808005283 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 279808005284 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 279808005285 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 279808005286 Cell division protein FtsL; Region: FtsL; cl11433 279808005287 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 279808005288 MraW methylase family; Region: Methyltransf_5; pfam01795 279808005289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 279808005290 MraZ protein; Region: MraZ; pfam02381 279808005291 MraZ protein; Region: MraZ; pfam02381 279808005292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 279808005293 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 279808005294 hypothetical protein; Provisional; Region: PRK13688 279808005295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 279808005296 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 279808005297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808005298 motif II; other site 279808005299 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 279808005300 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 279808005301 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 279808005302 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 279808005303 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 279808005304 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 279808005305 CHAP domain; Region: CHAP; pfam05257 279808005306 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 279808005307 active site 279808005308 metal binding site [ion binding]; metal-binding site 279808005309 holin, SPP1 family; Region: holin_SPP1; TIGR01592 279808005310 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 279808005311 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 279808005312 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 279808005313 putative active site [active] 279808005314 putative metal binding site [ion binding]; other site 279808005315 Phage tail protein; Region: Sipho_tail; pfam05709 279808005316 Phage-related protein [Function unknown]; Region: COG5412 279808005317 Phage-related protein [Function unknown]; Region: COG5412 279808005318 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 279808005319 Peptidase family M23; Region: Peptidase_M23; pfam01551 279808005320 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 279808005321 N-acetyl-D-glucosamine binding site [chemical binding]; other site 279808005322 catalytic residue [active] 279808005323 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 279808005324 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 279808005325 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 279808005326 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 279808005327 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 279808005328 Helix-turn-helix domain; Region: HTH_28; pfam13518 279808005329 Winged helix-turn helix; Region: HTH_29; pfam13551 279808005330 Homeodomain-like domain; Region: HTH_32; pfam13565 279808005331 Integrase core domain; Region: rve; pfam00665 279808005332 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 279808005333 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279808005334 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 279808005335 catalytic residues [active] 279808005336 catalytic nucleophile [active] 279808005337 Presynaptic Site I dimer interface [polypeptide binding]; other site 279808005338 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 279808005339 Synaptic Flat tetramer interface [polypeptide binding]; other site 279808005340 Synaptic Site I dimer interface [polypeptide binding]; other site 279808005341 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 279808005342 DNA-binding interface [nucleotide binding]; DNA binding site 279808005343 Predicted transcriptional regulator [Transcription]; Region: COG3682 279808005344 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 279808005345 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 279808005346 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 279808005347 beta-lactamase TEM; Provisional; Region: PRK15442 279808005348 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 279808005349 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 279808005350 Phage capsid family; Region: Phage_capsid; pfam05065 279808005351 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 279808005352 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 279808005353 oligomer interface [polypeptide binding]; other site 279808005354 active site residues [active] 279808005355 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 279808005356 Phage-related protein [Function unknown]; Region: COG4695; cl01923 279808005357 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 279808005358 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 279808005359 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 279808005360 active site 279808005361 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 279808005362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279808005363 ATP binding site [chemical binding]; other site 279808005364 putative Mg++ binding site [ion binding]; other site 279808005365 nucleotide binding region [chemical binding]; other site 279808005366 helicase superfamily c-terminal domain; Region: HELICc; smart00490 279808005367 ATP-binding site [chemical binding]; other site 279808005368 VRR-NUC domain; Region: VRR_NUC; pfam08774 279808005369 Virulence-associated protein E; Region: VirE; pfam05272 279808005370 Transcriptional activator RinB; Region: RinB; pfam06116 279808005371 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 279808005372 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 279808005373 putative metal binding site [ion binding]; other site 279808005374 Protein of unknown function (DUF968); Region: DUF968; pfam06147 279808005375 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 279808005376 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 279808005377 dimer interface [polypeptide binding]; other site 279808005378 ssDNA binding site [nucleotide binding]; other site 279808005379 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279808005380 ERF superfamily; Region: ERF; pfam04404 279808005381 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 279808005382 Domain of unknown function (DUF771); Region: DUF771; cl09962 279808005383 ORF6C domain; Region: ORF6C; pfam10552 279808005384 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 279808005385 AntA/AntB antirepressor; Region: AntA; pfam08346 279808005386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808005387 non-specific DNA binding site [nucleotide binding]; other site 279808005388 salt bridge; other site 279808005389 sequence-specific DNA binding site [nucleotide binding]; other site 279808005390 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808005391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808005392 non-specific DNA binding site [nucleotide binding]; other site 279808005393 salt bridge; other site 279808005394 sequence-specific DNA binding site [nucleotide binding]; other site 279808005395 Domain of unknown function (DUF955); Region: DUF955; pfam06114 279808005396 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 279808005397 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 279808005398 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 279808005399 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 279808005400 Int/Topo IB signature motif; other site 279808005401 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 279808005402 active site 279808005403 metal binding site [ion binding]; metal-binding site 279808005404 homotetramer interface [polypeptide binding]; other site 279808005405 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 279808005406 active site 279808005407 dimerization interface [polypeptide binding]; other site 279808005408 glutamate racemase; Provisional; Region: PRK00865 279808005409 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 279808005410 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 279808005411 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 279808005412 L-aspartate oxidase; Provisional; Region: PRK06175 279808005413 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 279808005414 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 279808005415 putative Iron-sulfur protein interface [polypeptide binding]; other site 279808005416 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 279808005417 proximal heme binding site [chemical binding]; other site 279808005418 distal heme binding site [chemical binding]; other site 279808005419 putative dimer interface [polypeptide binding]; other site 279808005420 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 279808005421 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 279808005422 GIY-YIG motif/motif A; other site 279808005423 active site 279808005424 catalytic site [active] 279808005425 putative DNA binding site [nucleotide binding]; other site 279808005426 metal binding site [ion binding]; metal-binding site 279808005427 UvrB/uvrC motif; Region: UVR; pfam02151 279808005428 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 279808005429 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279808005430 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 279808005431 catalytic residues [active] 279808005432 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 279808005433 MutS domain III; Region: MutS_III; pfam05192 279808005434 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 279808005435 Walker A/P-loop; other site 279808005436 ATP binding site [chemical binding]; other site 279808005437 Q-loop/lid; other site 279808005438 ABC transporter signature motif; other site 279808005439 Walker B; other site 279808005440 D-loop; other site 279808005441 H-loop/switch region; other site 279808005442 Smr domain; Region: Smr; pfam01713 279808005443 hypothetical protein; Provisional; Region: PRK08609 279808005444 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 279808005445 active site 279808005446 primer binding site [nucleotide binding]; other site 279808005447 NTP binding site [chemical binding]; other site 279808005448 metal binding triad [ion binding]; metal-binding site 279808005449 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 279808005450 active site 279808005451 Colicin V production protein; Region: Colicin_V; pfam02674 279808005452 Cell division protein ZapA; Region: ZapA; cl01146 279808005453 ribonuclease HIII; Provisional; Region: PRK00996 279808005454 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 279808005455 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 279808005456 RNA/DNA hybrid binding site [nucleotide binding]; other site 279808005457 active site 279808005458 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 279808005459 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 279808005460 putative tRNA-binding site [nucleotide binding]; other site 279808005461 B3/4 domain; Region: B3_4; pfam03483 279808005462 tRNA synthetase B5 domain; Region: B5; smart00874 279808005463 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 279808005464 dimer interface [polypeptide binding]; other site 279808005465 motif 1; other site 279808005466 motif 3; other site 279808005467 motif 2; other site 279808005468 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 279808005469 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 279808005470 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 279808005471 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 279808005472 dimer interface [polypeptide binding]; other site 279808005473 motif 1; other site 279808005474 active site 279808005475 motif 2; other site 279808005476 motif 3; other site 279808005477 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 279808005478 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 279808005479 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 279808005480 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 279808005481 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 279808005482 hypothetical protein; Provisional; Region: PRK13670 279808005483 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 279808005484 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 279808005485 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 279808005486 active site 279808005487 (T/H)XGH motif; other site 279808005488 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 279808005489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808005490 S-adenosylmethionine binding site [chemical binding]; other site 279808005491 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 279808005492 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279808005493 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 279808005494 putative active site [active] 279808005495 catalytic site [active] 279808005496 putative metal binding site [ion binding]; other site 279808005497 Protein of unknown function (DUF964); Region: DUF964; pfam06133 279808005498 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 279808005499 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 279808005500 Protein of unknown function (DUF420); Region: DUF420; pfam04238 279808005501 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 279808005502 UbiA prenyltransferase family; Region: UbiA; pfam01040 279808005503 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 279808005504 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 279808005505 pyruvate carboxylase; Reviewed; Region: PRK12999 279808005506 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 279808005507 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 279808005508 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 279808005509 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 279808005510 active site 279808005511 catalytic residues [active] 279808005512 metal binding site [ion binding]; metal-binding site 279808005513 homodimer binding site [polypeptide binding]; other site 279808005514 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 279808005515 carboxyltransferase (CT) interaction site; other site 279808005516 biotinylation site [posttranslational modification]; other site 279808005517 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 279808005518 hypothetical protein; Provisional; Region: PRK13666 279808005519 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 279808005520 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 279808005521 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 279808005522 G1 box; other site 279808005523 putative GEF interaction site [polypeptide binding]; other site 279808005524 GTP/Mg2+ binding site [chemical binding]; other site 279808005525 Switch I region; other site 279808005526 G2 box; other site 279808005527 G3 box; other site 279808005528 Switch II region; other site 279808005529 G4 box; other site 279808005530 G5 box; other site 279808005531 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 279808005532 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 279808005533 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 279808005534 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 279808005535 active site 279808005536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 279808005537 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 279808005538 manganese transport protein MntH; Reviewed; Region: PRK00701 279808005539 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 279808005540 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 279808005541 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 279808005542 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 279808005543 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 279808005544 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 279808005545 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 279808005546 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 279808005547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808005548 dimer interface [polypeptide binding]; other site 279808005549 conserved gate region; other site 279808005550 putative PBP binding loops; other site 279808005551 ABC-ATPase subunit interface; other site 279808005552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808005553 putative PBP binding loops; other site 279808005554 dimer interface [polypeptide binding]; other site 279808005555 ABC-ATPase subunit interface; other site 279808005556 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 279808005557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808005558 Walker A/P-loop; other site 279808005559 ATP binding site [chemical binding]; other site 279808005560 Q-loop/lid; other site 279808005561 ABC transporter signature motif; other site 279808005562 Walker B; other site 279808005563 D-loop; other site 279808005564 H-loop/switch region; other site 279808005565 TOBE domain; Region: TOBE_2; pfam08402 279808005566 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808005567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808005568 non-specific DNA binding site [nucleotide binding]; other site 279808005569 salt bridge; other site 279808005570 sequence-specific DNA binding site [nucleotide binding]; other site 279808005571 Cupin domain; Region: Cupin_2; pfam07883 279808005572 hypothetical protein; Provisional; Region: PRK04387 279808005573 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 279808005574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 279808005575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808005576 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279808005577 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 279808005578 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 279808005579 E3 interaction surface; other site 279808005580 lipoyl attachment site [posttranslational modification]; other site 279808005581 e3 binding domain; Region: E3_binding; pfam02817 279808005582 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 279808005583 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 279808005584 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 279808005585 alpha subunit interface [polypeptide binding]; other site 279808005586 TPP binding site [chemical binding]; other site 279808005587 heterodimer interface [polypeptide binding]; other site 279808005588 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 279808005589 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 279808005590 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 279808005591 TPP-binding site [chemical binding]; other site 279808005592 tetramer interface [polypeptide binding]; other site 279808005593 heterodimer interface [polypeptide binding]; other site 279808005594 phosphorylation loop region [posttranslational modification] 279808005595 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 279808005596 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 279808005597 active site 279808005598 catalytic residues [active] 279808005599 metal binding site [ion binding]; metal-binding site 279808005600 hypothetical protein; Provisional; Region: PRK13667 279808005601 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 279808005602 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 279808005603 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 279808005604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808005605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 279808005606 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 279808005607 TrkA-N domain; Region: TrkA_N; pfam02254 279808005608 TrkA-C domain; Region: TrkA_C; pfam02080 279808005609 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 279808005610 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 279808005611 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 279808005612 catalytic residues [active] 279808005613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808005614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808005615 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808005616 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808005617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808005618 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 279808005619 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 279808005620 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 279808005621 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 279808005622 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 279808005623 dimerization domain swap beta strand [polypeptide binding]; other site 279808005624 regulatory protein interface [polypeptide binding]; other site 279808005625 active site 279808005626 regulatory phosphorylation site [posttranslational modification]; other site 279808005627 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 279808005628 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 279808005629 putative RNA binding site [nucleotide binding]; other site 279808005630 Methyltransferase domain; Region: Methyltransf_26; pfam13659 279808005631 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 279808005632 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 279808005633 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279808005634 Walker A/P-loop; other site 279808005635 ATP binding site [chemical binding]; other site 279808005636 Q-loop/lid; other site 279808005637 ABC transporter signature motif; other site 279808005638 Walker B; other site 279808005639 D-loop; other site 279808005640 H-loop/switch region; other site 279808005641 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 279808005642 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 279808005643 Walker A/P-loop; other site 279808005644 ATP binding site [chemical binding]; other site 279808005645 Q-loop/lid; other site 279808005646 ABC transporter signature motif; other site 279808005647 Walker B; other site 279808005648 D-loop; other site 279808005649 H-loop/switch region; other site 279808005650 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 279808005651 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 279808005652 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 279808005653 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 279808005654 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 279808005655 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 279808005656 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 279808005657 purine monophosphate binding site [chemical binding]; other site 279808005658 dimer interface [polypeptide binding]; other site 279808005659 putative catalytic residues [active] 279808005660 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 279808005661 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 279808005662 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 279808005663 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 279808005664 active site 279808005665 substrate binding site [chemical binding]; other site 279808005666 cosubstrate binding site; other site 279808005667 catalytic site [active] 279808005668 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 279808005669 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 279808005670 dimerization interface [polypeptide binding]; other site 279808005671 putative ATP binding site [chemical binding]; other site 279808005672 amidophosphoribosyltransferase; Provisional; Region: PRK07272 279808005673 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 279808005674 active site 279808005675 tetramer interface [polypeptide binding]; other site 279808005676 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279808005677 active site 279808005678 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 279808005679 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 279808005680 dimerization interface [polypeptide binding]; other site 279808005681 ATP binding site [chemical binding]; other site 279808005682 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 279808005683 dimerization interface [polypeptide binding]; other site 279808005684 ATP binding site [chemical binding]; other site 279808005685 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 279808005686 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 279808005687 putative active site [active] 279808005688 catalytic triad [active] 279808005689 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 279808005690 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 279808005691 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 279808005692 ATP binding site [chemical binding]; other site 279808005693 active site 279808005694 substrate binding site [chemical binding]; other site 279808005695 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 279808005696 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 279808005697 NAD binding site [chemical binding]; other site 279808005698 ATP-grasp domain; Region: ATP-grasp; pfam02222 279808005699 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 279808005700 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 279808005701 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 279808005702 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 279808005703 homodimer interface [polypeptide binding]; other site 279808005704 NADP binding site [chemical binding]; other site 279808005705 substrate binding site [chemical binding]; other site 279808005706 Transposase IS200 like; Region: Y1_Tnp; pfam01797 279808005707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808005708 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808005709 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808005710 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 279808005711 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 279808005712 heme-binding site [chemical binding]; other site 279808005713 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 279808005714 FAD binding pocket [chemical binding]; other site 279808005715 FAD binding motif [chemical binding]; other site 279808005716 phosphate binding motif [ion binding]; other site 279808005717 beta-alpha-beta structure motif; other site 279808005718 NAD binding pocket [chemical binding]; other site 279808005719 Heme binding pocket [chemical binding]; other site 279808005720 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 279808005721 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 279808005722 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 279808005723 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 279808005724 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 279808005725 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 279808005726 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 279808005727 D-pathway; other site 279808005728 Putative ubiquinol binding site [chemical binding]; other site 279808005729 Low-spin heme (heme b) binding site [chemical binding]; other site 279808005730 Putative water exit pathway; other site 279808005731 Binuclear center (heme o3/CuB) [ion binding]; other site 279808005732 K-pathway; other site 279808005733 Putative proton exit pathway; other site 279808005734 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 279808005735 Subunit I/III interface [polypeptide binding]; other site 279808005736 Subunit III/IV interface [polypeptide binding]; other site 279808005737 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 279808005738 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 279808005739 active site 279808005740 tetramer interface [polypeptide binding]; other site 279808005741 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808005742 MULE transposase domain; Region: MULE; pfam10551 279808005743 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 279808005744 Beta-lactamase; Region: Beta-lactamase; pfam00144 279808005745 Transcriptional regulator [Transcription]; Region: LytR; COG1316 279808005746 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 279808005747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808005748 Coenzyme A binding pocket [chemical binding]; other site 279808005749 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 279808005750 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 279808005751 amidase catalytic site [active] 279808005752 Zn binding residues [ion binding]; other site 279808005753 substrate binding site [chemical binding]; other site 279808005754 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 279808005755 Lysozyme subfamily 2; Region: LYZ2; smart00047 279808005756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808005757 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808005758 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808005759 MarR family; Region: MarR; pfam01047 279808005760 MarR family; Region: MarR_2; cl17246 279808005761 TspO/MBR family; Region: TspO_MBR; pfam03073 279808005762 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 279808005763 Acyltransferase family; Region: Acyl_transf_3; pfam01757 279808005764 aminotransferase A; Validated; Region: PRK07683 279808005765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279808005766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808005767 homodimer interface [polypeptide binding]; other site 279808005768 catalytic residue [active] 279808005769 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 279808005770 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 279808005771 substrate binding site [chemical binding]; other site 279808005772 oxyanion hole (OAH) forming residues; other site 279808005773 trimer interface [polypeptide binding]; other site 279808005774 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 279808005775 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 279808005776 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 279808005777 dimer interface [polypeptide binding]; other site 279808005778 tetramer interface [polypeptide binding]; other site 279808005779 PYR/PP interface [polypeptide binding]; other site 279808005780 TPP binding site [chemical binding]; other site 279808005781 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 279808005782 TPP-binding site; other site 279808005783 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 279808005784 isochorismate synthases; Region: isochor_syn; TIGR00543 279808005785 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 279808005786 UbiA prenyltransferase family; Region: UbiA; pfam01040 279808005787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279808005788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808005789 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279808005790 Coenzyme A binding pocket [chemical binding]; other site 279808005791 TM2 domain; Region: TM2; pfam05154 279808005792 A short protein domain of unknown function; Region: IDEAL; smart00914 279808005793 ComK protein; Region: ComK; cl11560 279808005794 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808005795 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808005796 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 279808005797 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 279808005798 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 279808005799 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 279808005800 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 279808005801 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 279808005802 active site 279808005803 metal binding site [ion binding]; metal-binding site 279808005804 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279808005805 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 279808005806 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 279808005807 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 279808005808 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 279808005809 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 279808005810 protein binding site [polypeptide binding]; other site 279808005811 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 279808005812 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 279808005813 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 279808005814 G1 box; other site 279808005815 putative GEF interaction site [polypeptide binding]; other site 279808005816 GTP/Mg2+ binding site [chemical binding]; other site 279808005817 Switch I region; other site 279808005818 G2 box; other site 279808005819 G3 box; other site 279808005820 Switch II region; other site 279808005821 G4 box; other site 279808005822 G5 box; other site 279808005823 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 279808005824 YueH-like protein; Region: YueH; pfam14166 279808005825 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 279808005826 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 279808005827 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279808005828 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 279808005829 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 279808005830 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 279808005831 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 279808005832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808005833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279808005834 putative substrate translocation pore; other site 279808005835 hypothetical protein; Provisional; Region: PRK13679 279808005836 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 279808005837 Putative esterase; Region: Esterase; pfam00756 279808005838 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 279808005839 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 279808005840 Domain of unknown function DUF20; Region: UPF0118; pfam01594 279808005841 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 279808005842 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 279808005843 NAD binding site [chemical binding]; other site 279808005844 homotetramer interface [polypeptide binding]; other site 279808005845 homodimer interface [polypeptide binding]; other site 279808005846 substrate binding site [chemical binding]; other site 279808005847 active site 279808005848 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 279808005849 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 279808005850 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 279808005851 TrkA-N domain; Region: TrkA_N; pfam02254 279808005852 TrkA-C domain; Region: TrkA_C; pfam02080 279808005853 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 279808005854 MgtE intracellular N domain; Region: MgtE_N; smart00924 279808005855 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 279808005856 Divalent cation transporter; Region: MgtE; pfam01769 279808005857 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 279808005858 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 279808005859 active site 279808005860 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 279808005861 ATP-NAD kinase; Region: NAD_kinase; pfam01513 279808005862 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 279808005863 synthetase active site [active] 279808005864 NTP binding site [chemical binding]; other site 279808005865 metal binding site [ion binding]; metal-binding site 279808005866 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 279808005867 putative active site [active] 279808005868 putative metal binding residues [ion binding]; other site 279808005869 signature motif; other site 279808005870 putative triphosphate binding site [ion binding]; other site 279808005871 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 279808005872 apolar tunnel; other site 279808005873 heme binding site [chemical binding]; other site 279808005874 dimerization interface [polypeptide binding]; other site 279808005875 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 279808005876 Thioredoxin; Region: Thioredoxin_5; pfam13743 279808005877 oligoendopeptidase F; Region: pepF; TIGR00181 279808005878 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 279808005879 active site 279808005880 Zn binding site [ion binding]; other site 279808005881 Competence protein CoiA-like family; Region: CoiA; pfam06054 279808005882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808005883 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808005884 adaptor protein; Provisional; Region: PRK02315 279808005885 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 279808005886 ArsC family; Region: ArsC; pfam03960 279808005887 putative catalytic residues [active] 279808005888 thiol/disulfide switch; other site 279808005889 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 279808005890 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 279808005891 active site 279808005892 HIGH motif; other site 279808005893 dimer interface [polypeptide binding]; other site 279808005894 KMSKS motif; other site 279808005895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808005896 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808005897 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808005898 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808005899 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808005900 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 279808005901 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 279808005902 peptide binding site [polypeptide binding]; other site 279808005903 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 279808005904 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279808005905 Walker A/P-loop; other site 279808005906 ATP binding site [chemical binding]; other site 279808005907 Q-loop/lid; other site 279808005908 ABC transporter signature motif; other site 279808005909 Walker B; other site 279808005910 D-loop; other site 279808005911 H-loop/switch region; other site 279808005912 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279808005913 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 279808005914 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 279808005915 Walker A/P-loop; other site 279808005916 ATP binding site [chemical binding]; other site 279808005917 Q-loop/lid; other site 279808005918 ABC transporter signature motif; other site 279808005919 Walker B; other site 279808005920 D-loop; other site 279808005921 H-loop/switch region; other site 279808005922 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 279808005923 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 279808005924 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 279808005925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808005926 dimer interface [polypeptide binding]; other site 279808005927 conserved gate region; other site 279808005928 putative PBP binding loops; other site 279808005929 ABC-ATPase subunit interface; other site 279808005930 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 279808005931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808005932 dimer interface [polypeptide binding]; other site 279808005933 conserved gate region; other site 279808005934 putative PBP binding loops; other site 279808005935 ABC-ATPase subunit interface; other site 279808005936 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 279808005937 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 279808005938 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 279808005939 dimer interface [polypeptide binding]; other site 279808005940 active site 279808005941 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 279808005942 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 279808005943 dimer interface [polypeptide binding]; other site 279808005944 active site 279808005945 CoA binding pocket [chemical binding]; other site 279808005946 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 279808005947 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 279808005948 Clp amino terminal domain; Region: Clp_N; pfam02861 279808005949 Clp amino terminal domain; Region: Clp_N; pfam02861 279808005950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808005951 Walker A motif; other site 279808005952 ATP binding site [chemical binding]; other site 279808005953 Walker B motif; other site 279808005954 arginine finger; other site 279808005955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808005956 Walker A motif; other site 279808005957 ATP binding site [chemical binding]; other site 279808005958 Walker B motif; other site 279808005959 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 279808005960 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 279808005961 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 279808005962 catalytic triad [active] 279808005963 catalytic triad [active] 279808005964 oxyanion hole [active] 279808005965 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 279808005966 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 279808005967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808005968 active site 279808005969 motif I; other site 279808005970 motif II; other site 279808005971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808005972 coenzyme A disulfide reductase; Provisional; Region: PRK13512 279808005973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808005974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808005975 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279808005976 hypothetical protein; Provisional; Region: PRK13673 279808005977 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 279808005978 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 279808005979 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 279808005980 Part of AAA domain; Region: AAA_19; pfam13245 279808005981 Family description; Region: UvrD_C_2; pfam13538 279808005982 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 279808005983 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 279808005984 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 279808005985 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 279808005986 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279808005987 Catalytic site [active] 279808005988 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 279808005989 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279808005990 Catalytic site [active] 279808005991 Uncharacterized conserved protein [Function unknown]; Region: COG0398 279808005992 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 279808005993 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 279808005994 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 279808005995 active site 279808005996 dimer interface [polypeptide binding]; other site 279808005997 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 279808005998 dimer interface [polypeptide binding]; other site 279808005999 active site 279808006000 argininosuccinate synthase; Provisional; Region: PRK13820 279808006001 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 279808006002 ANP binding site [chemical binding]; other site 279808006003 Substrate Binding Site II [chemical binding]; other site 279808006004 Substrate Binding Site I [chemical binding]; other site 279808006005 argininosuccinate lyase; Provisional; Region: PRK00855 279808006006 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 279808006007 active sites [active] 279808006008 tetramer interface [polypeptide binding]; other site 279808006009 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 279808006010 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 279808006011 active site 279808006012 catalytic site [active] 279808006013 metal binding site [ion binding]; metal-binding site 279808006014 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 279808006015 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 279808006016 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 279808006017 NAD(P) binding site [chemical binding]; other site 279808006018 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 279808006019 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 279808006020 inhibitor-cofactor binding pocket; inhibition site 279808006021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808006022 catalytic residue [active] 279808006023 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 279808006024 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 279808006025 putative active site [active] 279808006026 putative FMN binding site [chemical binding]; other site 279808006027 putative substrate binding site [chemical binding]; other site 279808006028 putative catalytic residue [active] 279808006029 general stress protein 13; Validated; Region: PRK08059 279808006030 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 279808006031 RNA binding site [nucleotide binding]; other site 279808006032 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 279808006033 active site 279808006034 Kinase associated protein B; Region: KapB; pfam08810 279808006035 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 279808006036 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 279808006037 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 279808006038 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 279808006039 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 279808006040 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 279808006041 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 279808006042 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 279808006043 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 279808006044 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 279808006045 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 279808006046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808006047 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 279808006048 CoenzymeA binding site [chemical binding]; other site 279808006049 subunit interaction site [polypeptide binding]; other site 279808006050 PHB binding site; other site 279808006051 Predicted permease [General function prediction only]; Region: COG2056 279808006052 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 279808006053 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 279808006054 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 279808006055 interface (dimer of trimers) [polypeptide binding]; other site 279808006056 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 279808006057 Substrate-binding/catalytic site; other site 279808006058 Zn-binding sites [ion binding]; other site 279808006059 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 279808006060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808006061 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 279808006062 hypothetical protein; Provisional; Region: PRK13669 279808006063 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 279808006064 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808006065 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 279808006066 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 279808006067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808006068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808006069 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808006070 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 279808006071 DltD N-terminal region; Region: DltD_N; pfam04915 279808006072 DltD central region; Region: DltD_M; pfam04918 279808006073 DltD C-terminal region; Region: DltD_C; pfam04914 279808006074 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 279808006075 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 279808006076 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 279808006077 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 279808006078 acyl-activating enzyme (AAE) consensus motif; other site 279808006079 AMP binding site [chemical binding]; other site 279808006080 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 279808006081 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 279808006082 dimerization interface [polypeptide binding]; other site 279808006083 ligand binding site [chemical binding]; other site 279808006084 NADP binding site [chemical binding]; other site 279808006085 catalytic site [active] 279808006086 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 279808006087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808006088 active site 279808006089 motif I; other site 279808006090 motif II; other site 279808006091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808006092 Uncharacterized conserved protein [Function unknown]; Region: COG2445 279808006093 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 279808006094 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 279808006095 lipoyl synthase; Provisional; Region: PRK05481 279808006096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 279808006097 FeS/SAM binding site; other site 279808006098 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 279808006099 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 279808006100 active site 279808006101 metal binding site [ion binding]; metal-binding site 279808006102 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279808006103 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 279808006104 Uncharacterized conserved protein [Function unknown]; Region: COG1801 279808006105 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 279808006106 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 279808006107 FMN binding site [chemical binding]; other site 279808006108 substrate binding site [chemical binding]; other site 279808006109 putative catalytic residue [active] 279808006110 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808006111 MULE transposase domain; Region: MULE; pfam10551 279808006112 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 279808006113 FeS assembly protein SufB; Region: sufB; TIGR01980 279808006114 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 279808006115 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 279808006116 trimerization site [polypeptide binding]; other site 279808006117 active site 279808006118 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 279808006119 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 279808006120 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279808006121 catalytic residue [active] 279808006122 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 279808006123 FeS assembly protein SufD; Region: sufD; TIGR01981 279808006124 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 279808006125 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 279808006126 Walker A/P-loop; other site 279808006127 ATP binding site [chemical binding]; other site 279808006128 Q-loop/lid; other site 279808006129 ABC transporter signature motif; other site 279808006130 Walker B; other site 279808006131 D-loop; other site 279808006132 H-loop/switch region; other site 279808006133 Predicted membrane protein [Function unknown]; Region: COG2035 279808006134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808006135 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808006136 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808006137 CsbD-like; Region: CsbD; pfam05532 279808006138 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 279808006139 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 279808006140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808006141 dimer interface [polypeptide binding]; other site 279808006142 conserved gate region; other site 279808006143 ABC-ATPase subunit interface; other site 279808006144 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 279808006145 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 279808006146 Walker A/P-loop; other site 279808006147 ATP binding site [chemical binding]; other site 279808006148 Q-loop/lid; other site 279808006149 ABC transporter signature motif; other site 279808006150 Walker B; other site 279808006151 D-loop; other site 279808006152 H-loop/switch region; other site 279808006153 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 279808006154 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279808006155 catalytic residues [active] 279808006156 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 279808006157 putative active site [active] 279808006158 putative metal binding site [ion binding]; other site 279808006159 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 279808006160 lipoyl attachment site [posttranslational modification]; other site 279808006161 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 279808006162 ArsC family; Region: ArsC; pfam03960 279808006163 putative ArsC-like catalytic residues; other site 279808006164 putative TRX-like catalytic residues [active] 279808006165 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 279808006166 catalytic residues [active] 279808006167 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 279808006168 putative FMN binding site [chemical binding]; other site 279808006169 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 279808006170 active site 279808006171 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 279808006172 catalytic residue [active] 279808006173 dimer interface [polypeptide binding]; other site 279808006174 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 279808006175 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 279808006176 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279808006177 Lysine efflux permease [General function prediction only]; Region: COG1279 279808006178 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 279808006179 catalytic core [active] 279808006180 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 279808006181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808006182 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279808006183 Coenzyme A binding pocket [chemical binding]; other site 279808006184 Protein of unknown function (DUF867); Region: DUF867; pfam05908 279808006185 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808006186 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808006187 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 279808006188 Terminase small subunit; Region: Terminase_2; pfam03592 279808006189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 279808006190 DNA binding residues [nucleotide binding] 279808006191 Coat F domain; Region: Coat_F; cl17715 279808006192 seryl-tRNA synthetase; Region: PLN02320 279808006193 D5 N terminal like; Region: D5_N; smart00885 279808006194 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 279808006195 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 279808006196 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 279808006197 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808006198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808006199 non-specific DNA binding site [nucleotide binding]; other site 279808006200 salt bridge; other site 279808006201 sequence-specific DNA binding site [nucleotide binding]; other site 279808006202 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808006203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808006204 non-specific DNA binding site [nucleotide binding]; other site 279808006205 salt bridge; other site 279808006206 sequence-specific DNA binding site [nucleotide binding]; other site 279808006207 integrase; Provisional; Region: int; PHA02601 279808006208 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 279808006209 Int/Topo IB signature motif; other site 279808006210 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 279808006211 SmpB-tmRNA interface; other site 279808006212 ribonuclease R; Region: RNase_R; TIGR02063 279808006213 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 279808006214 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 279808006215 RNB domain; Region: RNB; pfam00773 279808006216 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 279808006217 RNA binding site [nucleotide binding]; other site 279808006218 Esterase/lipase [General function prediction only]; Region: COG1647 279808006219 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 279808006220 enolase; Provisional; Region: eno; PRK00077 279808006221 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 279808006222 dimer interface [polypeptide binding]; other site 279808006223 metal binding site [ion binding]; metal-binding site 279808006224 substrate binding pocket [chemical binding]; other site 279808006225 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 279808006226 phosphoglyceromutase; Provisional; Region: PRK05434 279808006227 triosephosphate isomerase; Provisional; Region: PRK14567 279808006228 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 279808006229 substrate binding site [chemical binding]; other site 279808006230 dimer interface [polypeptide binding]; other site 279808006231 catalytic triad [active] 279808006232 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 279808006233 Phosphoglycerate kinase; Region: PGK; pfam00162 279808006234 substrate binding site [chemical binding]; other site 279808006235 hinge regions; other site 279808006236 ADP binding site [chemical binding]; other site 279808006237 catalytic site [active] 279808006238 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 279808006239 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 279808006240 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 279808006241 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 279808006242 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 279808006243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808006244 TIGR01777 family protein; Region: yfcH 279808006245 NAD(P) binding site [chemical binding]; other site 279808006246 active site 279808006247 Clp protease; Region: CLP_protease; pfam00574 279808006248 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 279808006249 oligomer interface [polypeptide binding]; other site 279808006250 active site residues [active] 279808006251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 279808006252 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 279808006253 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 279808006254 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 279808006255 phosphate binding site [ion binding]; other site 279808006256 putative substrate binding pocket [chemical binding]; other site 279808006257 dimer interface [polypeptide binding]; other site 279808006258 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 279808006259 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 279808006260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808006261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808006262 TPR repeat; Region: TPR_11; pfam13414 279808006263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 279808006264 binding surface 279808006265 TPR motif; other site 279808006266 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 279808006267 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 279808006268 trimer interface [polypeptide binding]; other site 279808006269 active site 279808006270 substrate binding site [chemical binding]; other site 279808006271 CoA binding site [chemical binding]; other site 279808006272 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 279808006273 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 279808006274 HPr kinase/phosphorylase; Provisional; Region: PRK05428 279808006275 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 279808006276 Hpr binding site; other site 279808006277 active site 279808006278 homohexamer subunit interaction site [polypeptide binding]; other site 279808006279 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 279808006280 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 279808006281 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 279808006282 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 279808006283 excinuclease ABC subunit B; Provisional; Region: PRK05298 279808006284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279808006285 ATP binding site [chemical binding]; other site 279808006286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279808006287 nucleotide binding region [chemical binding]; other site 279808006288 ATP-binding site [chemical binding]; other site 279808006289 Ultra-violet resistance protein B; Region: UvrB; pfam12344 279808006290 UvrB/uvrC motif; Region: UVR; pfam02151 279808006291 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 279808006292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279808006293 Zn2+ binding site [ion binding]; other site 279808006294 Mg2+ binding site [ion binding]; other site 279808006295 similar to oxidoreductase; truncated or frameshifted 279808006296 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279808006297 Surface antigen [General function prediction only]; Region: COG3942 279808006298 CHAP domain; Region: CHAP; pfam05257 279808006299 peptide chain release factor 2; Provisional; Region: PRK06746 279808006300 This domain is found in peptide chain release factors; Region: PCRF; smart00937 279808006301 RF-1 domain; Region: RF-1; pfam00472 279808006302 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 279808006303 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 279808006304 SEC-C motif; Region: SEC-C; pfam02810 279808006305 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 279808006306 30S subunit binding site; other site 279808006307 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 279808006308 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279808006309 active site 279808006310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279808006311 putative Mg++ binding site [ion binding]; other site 279808006312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279808006313 nucleotide binding region [chemical binding]; other site 279808006314 ATP-binding site [chemical binding]; other site 279808006315 EDD domain protein, DegV family; Region: DegV; TIGR00762 279808006316 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 279808006317 Uncharacterized conserved protein [Function unknown]; Region: COG1739 279808006318 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 279808006319 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 279808006320 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14654 279808006321 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 279808006322 Mg++ binding site [ion binding]; other site 279808006323 putative catalytic motif [active] 279808006324 substrate binding site [chemical binding]; other site 279808006325 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 279808006326 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 279808006327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 279808006328 metal binding site [ion binding]; metal-binding site 279808006329 active site 279808006330 I-site; other site 279808006331 Uncharacterized conserved protein [Function unknown]; Region: COG2966 279808006332 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 279808006333 Uncharacterized conserved protein [Function unknown]; Region: COG3610 279808006334 peptidase T; Region: peptidase-T; TIGR01882 279808006335 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 279808006336 metal binding site [ion binding]; metal-binding site 279808006337 dimer interface [polypeptide binding]; other site 279808006338 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 279808006339 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 279808006340 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 279808006341 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 279808006342 FAD binding domain; Region: FAD_binding_4; pfam01565 279808006343 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 279808006344 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 279808006345 CHY zinc finger; Region: zf-CHY; pfam05495 279808006346 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 279808006347 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279808006348 putative ligand binding residues [chemical binding]; other site 279808006349 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 279808006350 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279808006351 putative ligand binding residues [chemical binding]; other site 279808006352 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 279808006353 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279808006354 Walker A/P-loop; other site 279808006355 ATP binding site [chemical binding]; other site 279808006356 Q-loop/lid; other site 279808006357 ABC transporter signature motif; other site 279808006358 Walker B; other site 279808006359 D-loop; other site 279808006360 H-loop/switch region; other site 279808006361 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279808006362 ABC-ATPase subunit interface; other site 279808006363 dimer interface [polypeptide binding]; other site 279808006364 putative PBP binding regions; other site 279808006365 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279808006366 ABC-ATPase subunit interface; other site 279808006367 dimer interface [polypeptide binding]; other site 279808006368 putative PBP binding regions; other site 279808006369 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 279808006370 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 279808006371 dimer interface [polypeptide binding]; other site 279808006372 putative radical transfer pathway; other site 279808006373 diiron center [ion binding]; other site 279808006374 tyrosyl radical; other site 279808006375 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 279808006376 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 279808006377 Class I ribonucleotide reductase; Region: RNR_I; cd01679 279808006378 active site 279808006379 dimer interface [polypeptide binding]; other site 279808006380 catalytic residues [active] 279808006381 effector binding site; other site 279808006382 R2 peptide binding site; other site 279808006383 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 279808006384 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 279808006385 EamA-like transporter family; Region: EamA; pfam00892 279808006386 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 279808006387 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 279808006388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808006389 putative substrate translocation pore; other site 279808006390 POT family; Region: PTR2; cl17359 279808006391 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 279808006392 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 279808006393 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 279808006394 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 279808006395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279808006396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808006397 homodimer interface [polypeptide binding]; other site 279808006398 catalytic residue [active] 279808006399 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 279808006400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808006401 putative substrate translocation pore; other site 279808006402 POT family; Region: PTR2; cl17359 279808006403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808006404 dimer interface [polypeptide binding]; other site 279808006405 conserved gate region; other site 279808006406 ABC-ATPase subunit interface; other site 279808006407 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 279808006408 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 279808006409 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 279808006410 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 279808006411 Walker A/P-loop; other site 279808006412 ATP binding site [chemical binding]; other site 279808006413 Q-loop/lid; other site 279808006414 ABC transporter signature motif; other site 279808006415 Walker B; other site 279808006416 D-loop; other site 279808006417 H-loop/switch region; other site 279808006418 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 279808006419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279808006420 ATP binding site [chemical binding]; other site 279808006421 putative Mg++ binding site [ion binding]; other site 279808006422 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279808006423 nucleotide binding region [chemical binding]; other site 279808006424 ATP-binding site [chemical binding]; other site 279808006425 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 279808006426 HRDC domain; Region: HRDC; pfam00570 279808006427 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279808006428 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808006429 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808006430 ABC transporter; Region: ABC_tran_2; pfam12848 279808006431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808006432 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 279808006433 ZIP Zinc transporter; Region: Zip; pfam02535 279808006434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808006435 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808006436 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808006437 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 279808006438 Sulfatase; Region: Sulfatase; pfam00884 279808006439 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 279808006440 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 279808006441 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 279808006442 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 279808006443 substrate-cofactor binding pocket; other site 279808006444 Aminotransferase class IV; Region: Aminotran_4; pfam01063 279808006445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808006446 aminodeoxychorismate synthase; Provisional; Region: PRK07508 279808006447 chorismate binding enzyme; Region: Chorismate_bind; cl10555 279808006448 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 279808006449 Glutamine amidotransferase class-I; Region: GATase; pfam00117 279808006450 glutamine binding [chemical binding]; other site 279808006451 catalytic triad [active] 279808006452 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 279808006453 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 279808006454 Ligand Binding Site [chemical binding]; other site 279808006455 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 279808006456 active site 279808006457 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 279808006458 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 279808006459 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 279808006460 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 279808006461 Ligand binding site; other site 279808006462 Putative Catalytic site; other site 279808006463 DXD motif; other site 279808006464 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808006465 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808006466 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279808006467 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279808006468 active site 279808006469 catalytic tetrad [active] 279808006470 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 279808006471 Domain of unknown function DUF21; Region: DUF21; pfam01595 279808006472 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 279808006473 Transporter associated domain; Region: CorC_HlyC; smart01091 279808006474 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 279808006475 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 279808006476 active site 279808006477 phosphorylation site [posttranslational modification] 279808006478 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 279808006479 active site 279808006480 P-loop; other site 279808006481 phosphorylation site [posttranslational modification] 279808006482 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 279808006483 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 279808006484 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 279808006485 putative substrate binding site [chemical binding]; other site 279808006486 putative ATP binding site [chemical binding]; other site 279808006487 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 279808006488 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 279808006489 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 279808006490 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 279808006491 putative deacylase active site [active] 279808006492 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 279808006493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808006494 putative substrate translocation pore; other site 279808006495 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 279808006496 trimer interface [polypeptide binding]; other site 279808006497 putative Zn binding site [ion binding]; other site 279808006498 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 279808006499 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 279808006500 DNA photolyase; Region: DNA_photolyase; pfam00875 279808006501 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 279808006502 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 279808006503 transmembrane helices; other site 279808006504 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 279808006505 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 279808006506 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 279808006507 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808006508 MarR family; Region: MarR; pfam01047 279808006509 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 279808006510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279808006511 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 279808006512 Walker A/P-loop; other site 279808006513 ATP binding site [chemical binding]; other site 279808006514 Q-loop/lid; other site 279808006515 ABC transporter signature motif; other site 279808006516 Walker B; other site 279808006517 D-loop; other site 279808006518 H-loop/switch region; other site 279808006519 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 279808006520 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279808006521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808006522 Walker A/P-loop; other site 279808006523 ATP binding site [chemical binding]; other site 279808006524 Q-loop/lid; other site 279808006525 ABC transporter signature motif; other site 279808006526 Walker B; other site 279808006527 D-loop; other site 279808006528 H-loop/switch region; other site 279808006529 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 279808006530 hypothetical protein; Validated; Region: PRK00124 279808006531 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 279808006532 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279808006533 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 279808006534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808006535 Coenzyme A binding pocket [chemical binding]; other site 279808006536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 279808006537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808006538 sugar efflux transporter; Region: 2A0120; TIGR00899 279808006539 putative substrate translocation pore; other site 279808006540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279808006541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279808006542 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279808006543 dimerization interface [polypeptide binding]; other site 279808006544 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 279808006545 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 279808006546 substrate binding site [chemical binding]; other site 279808006547 THF binding site; other site 279808006548 zinc-binding site [ion binding]; other site 279808006549 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 279808006550 hypothetical protein; Provisional; Region: PRK12378 279808006551 MarR family; Region: MarR_2; cl17246 279808006552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279808006553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279808006554 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 279808006555 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 279808006556 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279808006557 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279808006558 Surface antigen [General function prediction only]; Region: COG3942 279808006559 CHAP domain; Region: CHAP; pfam05257 279808006560 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 279808006561 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 279808006562 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 279808006563 FtsX-like permease family; Region: FtsX; pfam02687 279808006564 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279808006565 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279808006566 Walker A/P-loop; other site 279808006567 ATP binding site [chemical binding]; other site 279808006568 Q-loop/lid; other site 279808006569 ABC transporter signature motif; other site 279808006570 Walker B; other site 279808006571 D-loop; other site 279808006572 H-loop/switch region; other site 279808006573 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 279808006574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 279808006575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 279808006576 ATP binding site [chemical binding]; other site 279808006577 Mg2+ binding site [ion binding]; other site 279808006578 G-X-G motif; other site 279808006579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 279808006580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 279808006581 active site 279808006582 phosphorylation site [posttranslational modification] 279808006583 intermolecular recognition site; other site 279808006584 dimerization interface [polypeptide binding]; other site 279808006585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 279808006586 DNA binding site [nucleotide binding] 279808006587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 279808006588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808006589 Coenzyme A binding pocket [chemical binding]; other site 279808006590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279808006591 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 279808006592 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 279808006593 Uncharacterized membrane protein [Function unknown]; Region: COG3949 279808006594 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 279808006595 Na binding site [ion binding]; other site 279808006596 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 279808006597 DAK2 domain; Region: Dak2; cl03685 279808006598 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 279808006599 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 279808006600 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 279808006601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279808006602 ABC-ATPase subunit interface; other site 279808006603 dimer interface [polypeptide binding]; other site 279808006604 putative PBP binding regions; other site 279808006605 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 279808006606 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279808006607 ABC-ATPase subunit interface; other site 279808006608 dimer interface [polypeptide binding]; other site 279808006609 putative PBP binding regions; other site 279808006610 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 279808006611 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 279808006612 Walker A/P-loop; other site 279808006613 ATP binding site [chemical binding]; other site 279808006614 Q-loop/lid; other site 279808006615 ABC transporter signature motif; other site 279808006616 Walker B; other site 279808006617 D-loop; other site 279808006618 H-loop/switch region; other site 279808006619 Uncharacterized conserved protein [Function unknown]; Region: COG1284 279808006620 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 279808006621 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 279808006622 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 279808006623 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 279808006624 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 279808006625 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 279808006626 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279808006627 active site 279808006628 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 279808006629 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279808006630 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 279808006631 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 279808006632 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 279808006633 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 279808006634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 279808006635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808006636 Walker A/P-loop; other site 279808006637 ATP binding site [chemical binding]; other site 279808006638 Q-loop/lid; other site 279808006639 ABC transporter signature motif; other site 279808006640 Walker B; other site 279808006641 D-loop; other site 279808006642 H-loop/switch region; other site 279808006643 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 279808006644 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 279808006645 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 279808006646 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 279808006647 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 279808006648 active site 279808006649 nucleotide binding site [chemical binding]; other site 279808006650 HIGH motif; other site 279808006651 KMSKS motif; other site 279808006652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 279808006653 active site 279808006654 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 279808006655 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 279808006656 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 279808006657 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 279808006658 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 279808006659 Walker A/P-loop; other site 279808006660 ATP binding site [chemical binding]; other site 279808006661 Q-loop/lid; other site 279808006662 ABC transporter signature motif; other site 279808006663 Walker B; other site 279808006664 D-loop; other site 279808006665 H-loop/switch region; other site 279808006666 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 279808006667 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 279808006668 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 279808006669 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 279808006670 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 279808006671 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 279808006672 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 279808006673 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 279808006674 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 279808006675 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 279808006676 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 279808006677 metal binding site [ion binding]; metal-binding site 279808006678 dimer interface [polypeptide binding]; other site 279808006679 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 279808006680 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808006681 MULE transposase domain; Region: MULE; pfam10551 279808006682 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 279808006683 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 279808006684 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 279808006685 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 279808006686 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 279808006687 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 279808006688 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 279808006689 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 279808006690 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 279808006691 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 279808006692 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 279808006693 active site 279808006694 DNA binding site [nucleotide binding] 279808006695 Int/Topo IB signature motif; other site 279808006696 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 279808006697 Protein of unknown function, DUF606; Region: DUF606; pfam04657 279808006698 Protein of unknown function, DUF606; Region: DUF606; pfam04657 279808006699 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 279808006700 HlyD family secretion protein; Region: HlyD_3; pfam13437 279808006701 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 279808006702 Transcriptional regulators [Transcription]; Region: MarR; COG1846 279808006703 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808006704 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808006705 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 279808006706 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279808006707 Serine hydrolase (FSH1); Region: FSH1; pfam03959 279808006708 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 279808006709 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279808006710 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 279808006711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808006712 motif II; other site 279808006713 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 279808006714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 279808006715 ABC-ATPase subunit interface; other site 279808006716 dimer interface [polypeptide binding]; other site 279808006717 putative PBP binding regions; other site 279808006718 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 279808006719 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 279808006720 putative binding site residues; other site 279808006721 Protein of unknown function (DUF805); Region: DUF805; pfam05656 279808006722 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 279808006723 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 279808006724 DNA binding residues [nucleotide binding] 279808006725 dimer interface [polypeptide binding]; other site 279808006726 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 279808006727 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 279808006728 endonuclease III; Region: ENDO3c; smart00478 279808006729 minor groove reading motif; other site 279808006730 helix-hairpin-helix signature motif; other site 279808006731 substrate binding pocket [chemical binding]; other site 279808006732 active site 279808006733 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 279808006734 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 279808006735 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 279808006736 active site 279808006737 HIGH motif; other site 279808006738 KMSK motif region; other site 279808006739 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 279808006740 tRNA binding surface [nucleotide binding]; other site 279808006741 anticodon binding site; other site 279808006742 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 279808006743 Replication protein; Region: Rep_1; cl02412 279808006744 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 279808006745 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 279808006746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808006747 Walker A/P-loop; other site 279808006748 ATP binding site [chemical binding]; other site 279808006749 Q-loop/lid; other site 279808006750 ABC transporter signature motif; other site 279808006751 Walker B; other site 279808006752 D-loop; other site 279808006753 H-loop/switch region; other site 279808006754 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808006755 ABC transporter; Region: ABC_tran; pfam00005 279808006756 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808006757 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 279808006758 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 279808006759 Phosphotransferase enzyme family; Region: APH; pfam01636 279808006760 putative active site [active] 279808006761 putative substrate binding site [chemical binding]; other site 279808006762 ATP binding site [chemical binding]; other site 279808006763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808006764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808006765 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 279808006766 multiple promoter invertase; Provisional; Region: mpi; PRK13413 279808006767 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 279808006768 catalytic residues [active] 279808006769 catalytic nucleophile [active] 279808006770 Presynaptic Site I dimer interface [polypeptide binding]; other site 279808006771 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 279808006772 Synaptic Flat tetramer interface [polypeptide binding]; other site 279808006773 Synaptic Site I dimer interface [polypeptide binding]; other site 279808006774 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 279808006775 DNA-binding interface [nucleotide binding]; DNA binding site 279808006776 multiple promoter invertase; Provisional; Region: mpi; PRK13413 279808006777 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 279808006778 catalytic residues [active] 279808006779 catalytic nucleophile [active] 279808006780 Presynaptic Site I dimer interface [polypeptide binding]; other site 279808006781 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 279808006782 Synaptic Flat tetramer interface [polypeptide binding]; other site 279808006783 Synaptic Site I dimer interface [polypeptide binding]; other site 279808006784 DNA binding site [nucleotide binding] 279808006785 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 279808006786 DNA-binding interface [nucleotide binding]; DNA binding site 279808006787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808006788 non-specific DNA binding site [nucleotide binding]; other site 279808006789 salt bridge; other site 279808006790 sequence-specific DNA binding site [nucleotide binding]; other site 279808006791 Peptidase family M23; Region: Peptidase_M23; pfam01551 279808006792 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 279808006793 cyanate transporter; Region: CynX; TIGR00896 279808006794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808006795 putative substrate translocation pore; other site 279808006796 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 279808006797 Cadmium resistance transporter; Region: Cad; pfam03596 279808006798 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 279808006799 putative DNA binding site [nucleotide binding]; other site 279808006800 putative Zn2+ binding site [ion binding]; other site 279808006801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 279808006802 Integrase core domain; Region: rve; pfam00665 279808006803 YwhD family; Region: YwhD; pfam08741 279808006804 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 279808006805 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 279808006806 Zn2+ binding site [ion binding]; other site 279808006807 Mg2+ binding site [ion binding]; other site 279808006808 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 279808006809 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 279808006810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808006811 Coenzyme A binding pocket [chemical binding]; other site 279808006812 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 279808006813 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279808006814 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 279808006815 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 279808006816 active site 279808006817 catalytic tetrad [active] 279808006818 Transcriptional regulator; Region: Rrf2; pfam02082 279808006819 Rrf2 family protein; Region: rrf2_super; TIGR00738 279808006820 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 279808006821 CHAP domain; Region: CHAP; pfam05257 279808006822 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 279808006823 amidase catalytic site [active] 279808006824 Zn binding residues [ion binding]; other site 279808006825 substrate binding site [chemical binding]; other site 279808006826 Bacterial SH3 domain; Region: SH3_5; pfam08460 279808006827 Bacteriophage holin; Region: Phage_holin_1; pfam04531 279808006828 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 279808006829 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 279808006830 active site 279808006831 catalytic triad [active] 279808006832 oxyanion hole [active] 279808006833 CHAP domain; Region: CHAP; pfam05257 279808006834 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 279808006835 Lysozyme subfamily 2; Region: LYZ2; smart00047 279808006836 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 279808006837 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 279808006838 B-Box C-terminal domain; Region: BBC; smart00502 279808006839 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 279808006840 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 279808006841 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 279808006842 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 279808006843 active site 279808006844 catalytic triad [active] 279808006845 oxyanion hole [active] 279808006846 Phage tail protein; Region: Sipho_tail; pfam05709 279808006847 Phage-related protein [Function unknown]; Region: COG5412 279808006848 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 279808006849 Phage protein; Region: DUF3647; pfam12363 279808006850 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 279808006851 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 279808006852 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 279808006853 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 279808006854 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 279808006855 Phage capsid family; Region: Phage_capsid; pfam05065 279808006856 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 279808006857 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 279808006858 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 279808006859 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 279808006860 Terminase-like family; Region: Terminase_6; pfam03237 279808006861 Phage terminase large subunit; Region: Terminase_3; cl12054 279808006862 Helix-turn-helix domain; Region: HTH_38; pfam13936 279808006863 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 279808006864 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 279808006865 Transcriptional activator RinB; Region: RinB; pfam06116 279808006866 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 279808006867 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 279808006868 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 279808006869 trimer interface [polypeptide binding]; other site 279808006870 active site 279808006871 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 279808006872 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 279808006873 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 279808006874 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 279808006875 hypothetical protein; Validated; Region: PRK08116 279808006876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808006877 Walker A motif; other site 279808006878 ATP binding site [chemical binding]; other site 279808006879 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 279808006880 AP2 domain; Region: AP2; pfam00847 279808006881 DNA binding site [nucleotide binding] 279808006882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808006883 sequence-specific DNA binding site [nucleotide binding]; other site 279808006884 salt bridge; other site 279808006885 Protein of unknown function (DUF968); Region: DUF968; pfam06147 279808006886 AAA domain; Region: AAA_24; pfam13479 279808006887 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 279808006888 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 279808006889 ORF6C domain; Region: ORF6C; pfam10552 279808006890 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 279808006891 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 279808006892 non-specific DNA binding site [nucleotide binding]; other site 279808006893 salt bridge; other site 279808006894 sequence-specific DNA binding site [nucleotide binding]; other site 279808006895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808006896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808006897 non-specific DNA binding site [nucleotide binding]; other site 279808006898 salt bridge; other site 279808006899 sequence-specific DNA binding site [nucleotide binding]; other site 279808006900 Predicted transcriptional regulator [Transcription]; Region: COG2932 279808006901 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 279808006902 Catalytic site [active] 279808006903 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279808006904 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 279808006905 catalytic residues [active] 279808006906 catalytic nucleophile [active] 279808006907 Presynaptic Site I dimer interface [polypeptide binding]; other site 279808006908 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 279808006909 Synaptic Flat tetramer interface [polypeptide binding]; other site 279808006910 Synaptic Site I dimer interface [polypeptide binding]; other site 279808006911 DNA binding site [nucleotide binding] 279808006912 Recombinase; Region: Recombinase; pfam07508 279808006913 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 279808006914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808006915 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 279808006916 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 279808006917 DNA-binding site [nucleotide binding]; DNA binding site 279808006918 RNA-binding motif; other site 279808006919 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 279808006920 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 279808006921 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 279808006922 diphosphomevalonate decarboxylase; Region: PLN02407 279808006923 mevalonate kinase; Region: mevalon_kin; TIGR00549 279808006924 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 279808006925 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 279808006926 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 279808006927 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 279808006928 putative heme peroxidase; Provisional; Region: PRK12276 279808006929 Uncharacterized conserved protein [Function unknown]; Region: COG2966 279808006930 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 279808006931 Uncharacterized conserved protein [Function unknown]; Region: COG3610 279808006932 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 279808006933 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 279808006934 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 279808006935 ligand binding site [chemical binding]; other site 279808006936 active site 279808006937 UGI interface [polypeptide binding]; other site 279808006938 catalytic site [active] 279808006939 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 279808006940 dimer interface [polypeptide binding]; other site 279808006941 substrate binding site [chemical binding]; other site 279808006942 ATP binding site [chemical binding]; other site 279808006943 proline/glycine betaine transporter; Provisional; Region: PRK10642 279808006944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808006945 putative substrate translocation pore; other site 279808006946 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 279808006947 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 279808006948 dimer interface [polypeptide binding]; other site 279808006949 active site 279808006950 acyl-CoA synthetase; Validated; Region: PRK07638 279808006951 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 279808006952 acyl-activating enzyme (AAE) consensus motif; other site 279808006953 AMP binding site [chemical binding]; other site 279808006954 active site 279808006955 CoA binding site [chemical binding]; other site 279808006956 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 279808006957 tetramer interface [polypeptide binding]; other site 279808006958 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 279808006959 active site 279808006960 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 279808006961 active site 279808006962 dimer interface [polypeptide binding]; other site 279808006963 magnesium binding site [ion binding]; other site 279808006964 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 279808006965 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 279808006966 putative GTP cyclohydrolase; Provisional; Region: PRK13674 279808006967 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 279808006968 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 279808006969 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 279808006970 Rib/alpha-like repeat; Region: Rib; cl07159 279808006971 Rib/alpha-like repeat; Region: Rib; cl07159 279808006972 Rib/alpha-like repeat; Region: Rib; cl07159 279808006973 Rib/alpha-like repeat; Region: Rib; cl07159 279808006974 Rib/alpha-like repeat; Region: Rib; cl07159 279808006975 Rib/alpha-like repeat; Region: Rib; cl07159 279808006976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808006977 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808006978 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808006979 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 279808006980 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 279808006981 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 279808006982 Predicted flavoprotein [General function prediction only]; Region: COG0431 279808006983 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 279808006984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808006985 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 279808006986 active site 279808006987 motif I; other site 279808006988 motif II; other site 279808006989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808006990 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 279808006991 nucleoside/Zn binding site; other site 279808006992 dimer interface [polypeptide binding]; other site 279808006993 catalytic motif [active] 279808006994 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 279808006995 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 279808006996 Substrate-binding site [chemical binding]; other site 279808006997 Substrate specificity [chemical binding]; other site 279808006998 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 279808006999 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 279808007000 Substrate-binding site [chemical binding]; other site 279808007001 Substrate specificity [chemical binding]; other site 279808007002 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 279808007003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 279808007004 motif II; other site 279808007005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808007006 Coenzyme A binding pocket [chemical binding]; other site 279808007007 Fic/DOC family; Region: Fic; pfam02661 279808007008 Fic family protein [Function unknown]; Region: COG3177 279808007009 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 279808007010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808007011 Coenzyme A binding pocket [chemical binding]; other site 279808007012 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279808007013 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279808007014 active site 279808007015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808007016 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808007017 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808007018 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808007019 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 279808007020 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 279808007021 homodimer interface [polypeptide binding]; other site 279808007022 substrate-cofactor binding pocket; other site 279808007023 catalytic residue [active] 279808007024 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 279808007025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808007026 NAD(P) binding site [chemical binding]; other site 279808007027 active site 279808007028 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 279808007029 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 279808007030 active site 279808007031 metal binding site [ion binding]; metal-binding site 279808007032 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 279808007033 ornithine cyclodeaminase; Validated; Region: PRK08618 279808007034 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 279808007035 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 279808007036 nudix motif; other site 279808007037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 279808007038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808007039 Coenzyme A binding pocket [chemical binding]; other site 279808007040 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 279808007041 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 279808007042 substrate-cofactor binding pocket; other site 279808007043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808007044 catalytic residue [active] 279808007045 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 279808007046 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 279808007047 metal binding site [ion binding]; metal-binding site 279808007048 dimer interface [polypeptide binding]; other site 279808007049 elongation factor Tu; Reviewed; Region: PRK00049 279808007050 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 279808007051 G1 box; other site 279808007052 GEF interaction site [polypeptide binding]; other site 279808007053 GTP/Mg2+ binding site [chemical binding]; other site 279808007054 Switch I region; other site 279808007055 G2 box; other site 279808007056 G3 box; other site 279808007057 Switch II region; other site 279808007058 G4 box; other site 279808007059 G5 box; other site 279808007060 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 279808007061 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 279808007062 Antibiotic Binding Site [chemical binding]; other site 279808007063 elongation factor G; Reviewed; Region: PRK00007 279808007064 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 279808007065 G1 box; other site 279808007066 putative GEF interaction site [polypeptide binding]; other site 279808007067 GTP/Mg2+ binding site [chemical binding]; other site 279808007068 Switch I region; other site 279808007069 G2 box; other site 279808007070 G3 box; other site 279808007071 Switch II region; other site 279808007072 G4 box; other site 279808007073 G5 box; other site 279808007074 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 279808007075 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 279808007076 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 279808007077 30S ribosomal protein S7; Validated; Region: PRK05302 279808007078 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 279808007079 S17 interaction site [polypeptide binding]; other site 279808007080 S8 interaction site; other site 279808007081 16S rRNA interaction site [nucleotide binding]; other site 279808007082 streptomycin interaction site [chemical binding]; other site 279808007083 23S rRNA interaction site [nucleotide binding]; other site 279808007084 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 279808007085 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 279808007086 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 279808007087 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 279808007088 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 279808007089 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 279808007090 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 279808007091 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 279808007092 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 279808007093 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 279808007094 G-loop; other site 279808007095 DNA binding site [nucleotide binding] 279808007096 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 279808007097 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 279808007098 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 279808007099 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 279808007100 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 279808007101 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 279808007102 RPB12 interaction site [polypeptide binding]; other site 279808007103 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 279808007104 RPB10 interaction site [polypeptide binding]; other site 279808007105 RPB1 interaction site [polypeptide binding]; other site 279808007106 RPB11 interaction site [polypeptide binding]; other site 279808007107 RPB3 interaction site [polypeptide binding]; other site 279808007108 RPB12 interaction site [polypeptide binding]; other site 279808007109 Methyltransferase domain; Region: Methyltransf_31; pfam13847 279808007110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808007111 S-adenosylmethionine binding site [chemical binding]; other site 279808007112 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 279808007113 peripheral dimer interface [polypeptide binding]; other site 279808007114 core dimer interface [polypeptide binding]; other site 279808007115 L10 interface [polypeptide binding]; other site 279808007116 L11 interface [polypeptide binding]; other site 279808007117 putative EF-Tu interaction site [polypeptide binding]; other site 279808007118 putative EF-G interaction site [polypeptide binding]; other site 279808007119 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 279808007120 23S rRNA interface [nucleotide binding]; other site 279808007121 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 279808007122 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808007123 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808007124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808007125 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808007126 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 279808007127 mRNA/rRNA interface [nucleotide binding]; other site 279808007128 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 279808007129 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 279808007130 23S rRNA interface [nucleotide binding]; other site 279808007131 L7/L12 interface [polypeptide binding]; other site 279808007132 putative thiostrepton binding site; other site 279808007133 L25 interface [polypeptide binding]; other site 279808007134 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 279808007135 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 279808007136 putative homodimer interface [polypeptide binding]; other site 279808007137 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 279808007138 heterodimer interface [polypeptide binding]; other site 279808007139 homodimer interface [polypeptide binding]; other site 279808007140 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 279808007141 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 279808007142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 279808007143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 279808007144 DNA binding residues [nucleotide binding] 279808007145 YacP-like NYN domain; Region: NYN_YacP; cl01491 279808007146 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 279808007147 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 279808007148 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 279808007149 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 279808007150 active site 279808007151 metal binding site [ion binding]; metal-binding site 279808007152 dimerization interface [polypeptide binding]; other site 279808007153 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 279808007154 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 279808007155 active site 279808007156 HIGH motif; other site 279808007157 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 279808007158 KMSKS motif; other site 279808007159 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 279808007160 tRNA binding surface [nucleotide binding]; other site 279808007161 anticodon binding site; other site 279808007162 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 279808007163 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 279808007164 trimer interface [polypeptide binding]; other site 279808007165 active site 279808007166 substrate binding site [chemical binding]; other site 279808007167 CoA binding site [chemical binding]; other site 279808007168 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 279808007169 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 279808007170 active site 279808007171 HIGH motif; other site 279808007172 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 279808007173 active site 279808007174 KMSKS motif; other site 279808007175 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 279808007176 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 279808007177 putative active site [active] 279808007178 DNA repair protein RadA; Provisional; Region: PRK11823 279808007179 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 279808007180 Walker A motif/ATP binding site; other site 279808007181 ATP binding site [chemical binding]; other site 279808007182 Walker B motif; other site 279808007183 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 279808007184 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 279808007185 Clp amino terminal domain; Region: Clp_N; pfam02861 279808007186 Clp amino terminal domain; Region: Clp_N; pfam02861 279808007187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808007188 Walker A motif; other site 279808007189 ATP binding site [chemical binding]; other site 279808007190 Walker B motif; other site 279808007191 arginine finger; other site 279808007192 UvrB/uvrC motif; Region: UVR; pfam02151 279808007193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808007194 Walker A motif; other site 279808007195 ATP binding site [chemical binding]; other site 279808007196 Walker B motif; other site 279808007197 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 279808007198 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 279808007199 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 279808007200 ADP binding site [chemical binding]; other site 279808007201 phosphagen binding site; other site 279808007202 substrate specificity loop; other site 279808007203 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 279808007204 UvrB/uvrC motif; Region: UVR; pfam02151 279808007205 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 279808007206 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 279808007207 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 279808007208 Nucleoside recognition; Region: Gate; pfam07670 279808007209 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 279808007210 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 279808007211 predicted active site [active] 279808007212 catalytic triad [active] 279808007213 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 279808007214 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 279808007215 active site 279808007216 multimer interface [polypeptide binding]; other site 279808007217 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 279808007218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279808007219 DNA-binding site [nucleotide binding]; DNA binding site 279808007220 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 279808007221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808007222 homodimer interface [polypeptide binding]; other site 279808007223 catalytic residue [active] 279808007224 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 279808007225 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 279808007226 dimer interface [polypeptide binding]; other site 279808007227 putative anticodon binding site; other site 279808007228 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 279808007229 motif 1; other site 279808007230 active site 279808007231 motif 2; other site 279808007232 motif 3; other site 279808007233 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 279808007234 catalytic center binding site [active] 279808007235 ATP binding site [chemical binding]; other site 279808007236 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 279808007237 homooctamer interface [polypeptide binding]; other site 279808007238 active site 279808007239 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 279808007240 dihydropteroate synthase; Region: DHPS; TIGR01496 279808007241 substrate binding pocket [chemical binding]; other site 279808007242 dimer interface [polypeptide binding]; other site 279808007243 inhibitor binding site; inhibition site 279808007244 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 279808007245 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 279808007246 dimer interface [polypeptide binding]; other site 279808007247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808007248 catalytic residue [active] 279808007249 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 279808007250 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 279808007251 dimerization interface [polypeptide binding]; other site 279808007252 domain crossover interface; other site 279808007253 redox-dependent activation switch; other site 279808007254 FtsH Extracellular; Region: FtsH_ext; pfam06480 279808007255 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 279808007256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808007257 Walker A motif; other site 279808007258 ATP binding site [chemical binding]; other site 279808007259 Walker B motif; other site 279808007260 arginine finger; other site 279808007261 Peptidase family M41; Region: Peptidase_M41; pfam01434 279808007262 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 279808007263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279808007264 active site 279808007265 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 279808007266 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 279808007267 Ligand Binding Site [chemical binding]; other site 279808007268 TilS substrate C-terminal domain; Region: TilS_C; smart00977 279808007269 hypothetical protein; Provisional; Region: PRK08582 279808007270 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 279808007271 RNA binding site [nucleotide binding]; other site 279808007272 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 279808007273 Septum formation initiator; Region: DivIC; pfam04977 279808007274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 279808007275 RNA binding surface [nucleotide binding]; other site 279808007276 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 279808007277 putative SAM binding site [chemical binding]; other site 279808007278 putative homodimer interface [polypeptide binding]; other site 279808007279 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 279808007280 homodimer interface [polypeptide binding]; other site 279808007281 metal binding site [ion binding]; metal-binding site 279808007282 stage V sporulation protein B; Region: spore_V_B; TIGR02900 279808007283 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 279808007284 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 279808007285 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 279808007286 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 279808007287 ATP binding site [chemical binding]; other site 279808007288 putative Mg++ binding site [ion binding]; other site 279808007289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 279808007290 nucleotide binding region [chemical binding]; other site 279808007291 ATP-binding site [chemical binding]; other site 279808007292 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 279808007293 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 279808007294 putative active site [active] 279808007295 catalytic residue [active] 279808007296 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 279808007297 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 279808007298 5S rRNA interface [nucleotide binding]; other site 279808007299 CTC domain interface [polypeptide binding]; other site 279808007300 L16 interface [polypeptide binding]; other site 279808007301 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 279808007302 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 279808007303 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279808007304 active site 279808007305 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 279808007306 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 279808007307 Substrate binding site; other site 279808007308 Mg++ binding site; other site 279808007309 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 279808007310 active site 279808007311 substrate binding site [chemical binding]; other site 279808007312 CoA binding site [chemical binding]; other site 279808007313 regulatory protein SpoVG; Reviewed; Region: PRK13259 279808007314 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 279808007315 homotrimer interaction site [polypeptide binding]; other site 279808007316 putative active site [active] 279808007317 pur operon repressor; Provisional; Region: PRK09213 279808007318 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 279808007319 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279808007320 active site 279808007321 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 279808007322 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 279808007323 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 279808007324 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 279808007325 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 279808007326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808007327 S-adenosylmethionine binding site [chemical binding]; other site 279808007328 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 279808007329 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 279808007330 putative active site [active] 279808007331 putative metal binding site [ion binding]; other site 279808007332 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 279808007333 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 279808007334 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 279808007335 active site 279808007336 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 279808007337 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 279808007338 active site 279808007339 HIGH motif; other site 279808007340 KMSKS motif; other site 279808007341 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 279808007342 tRNA binding surface [nucleotide binding]; other site 279808007343 anticodon binding site; other site 279808007344 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 279808007345 dimer interface [polypeptide binding]; other site 279808007346 putative tRNA-binding site [nucleotide binding]; other site 279808007347 Predicted methyltransferases [General function prediction only]; Region: COG0313 279808007348 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 279808007349 putative SAM binding site [chemical binding]; other site 279808007350 putative homodimer interface [polypeptide binding]; other site 279808007351 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 279808007352 GIY-YIG motif/motif A; other site 279808007353 putative active site [active] 279808007354 putative metal binding site [ion binding]; other site 279808007355 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 279808007356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808007357 S-adenosylmethionine binding site [chemical binding]; other site 279808007358 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 279808007359 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 279808007360 DNA polymerase III subunit delta'; Validated; Region: PRK08058 279808007361 DNA polymerase III subunit delta'; Validated; Region: PRK08485 279808007362 Protein of unknown function (DUF970); Region: DUF970; pfam06153 279808007363 thymidylate kinase; Validated; Region: tmk; PRK00698 279808007364 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 279808007365 TMP-binding site; other site 279808007366 ATP-binding site [chemical binding]; other site 279808007367 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 279808007368 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 279808007369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 279808007370 catalytic residue [active] 279808007371 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 279808007372 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279808007373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808007374 Coenzyme A binding pocket [chemical binding]; other site 279808007375 recombination protein RecR; Reviewed; Region: recR; PRK00076 279808007376 RecR protein; Region: RecR; pfam02132 279808007377 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 279808007378 putative active site [active] 279808007379 putative metal-binding site [ion binding]; other site 279808007380 tetramer interface [polypeptide binding]; other site 279808007381 hypothetical protein; Validated; Region: PRK00153 279808007382 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 279808007383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 279808007384 Walker A motif; other site 279808007385 ATP binding site [chemical binding]; other site 279808007386 DNA polymerase III subunit delta'; Validated; Region: PRK08485 279808007387 Walker B motif; other site 279808007388 arginine finger; other site 279808007389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808007390 Coenzyme A binding pocket [chemical binding]; other site 279808007391 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 279808007392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 279808007393 DNA-binding site [nucleotide binding]; DNA binding site 279808007394 UTRA domain; Region: UTRA; pfam07702 279808007395 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 279808007396 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 279808007397 Ca binding site [ion binding]; other site 279808007398 active site 279808007399 catalytic site [active] 279808007400 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 279808007401 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 279808007402 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 279808007403 active site turn [active] 279808007404 phosphorylation site [posttranslational modification] 279808007405 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 279808007406 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 279808007407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808007408 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 279808007409 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 279808007410 active site 279808007411 dimer interface [polypeptide binding]; other site 279808007412 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 279808007413 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 279808007414 active site 279808007415 FMN binding site [chemical binding]; other site 279808007416 substrate binding site [chemical binding]; other site 279808007417 3Fe-4S cluster binding site [ion binding]; other site 279808007418 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 279808007419 domain interface; other site 279808007420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 279808007421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 279808007422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 279808007423 dimerization interface [polypeptide binding]; other site 279808007424 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 279808007425 YibE/F-like protein; Region: YibE_F; cl02259 279808007426 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 279808007427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808007428 Coenzyme A binding pocket [chemical binding]; other site 279808007429 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 279808007430 nudix motif; other site 279808007431 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279808007432 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279808007433 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 279808007434 Surface antigen [General function prediction only]; Region: COG3942 279808007435 CHAP domain; Region: CHAP; pfam05257 279808007436 cystathionine beta-lyase; Provisional; Region: PRK07671 279808007437 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279808007438 homodimer interface [polypeptide binding]; other site 279808007439 substrate-cofactor binding pocket; other site 279808007440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808007441 catalytic residue [active] 279808007442 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 279808007443 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 279808007444 dimer interface [polypeptide binding]; other site 279808007445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808007446 catalytic residue [active] 279808007447 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 279808007448 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 279808007449 putative substrate binding site 2 [chemical binding]; other site 279808007450 putative substrate binding site 1 [chemical binding]; other site 279808007451 Na binding site 1 [ion binding]; other site 279808007452 Na2 binding site [ion binding]; other site 279808007453 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 279808007454 Esterase/lipase [General function prediction only]; Region: COG1647 279808007455 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 279808007456 Patatin-like phospholipase; Region: Patatin; pfam01734 279808007457 nucleophile elbow; other site 279808007458 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 279808007459 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 279808007460 active site 279808007461 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279808007462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279808007463 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 279808007464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 279808007465 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 279808007466 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 279808007467 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 279808007468 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 279808007469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 279808007470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808007471 Coenzyme A binding pocket [chemical binding]; other site 279808007472 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 279808007473 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 279808007474 Terminase small subunit; Region: Terminase_2; pfam03592 279808007475 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 279808007476 DNA binding residues [nucleotide binding] 279808007477 Coat F domain; Region: Coat_F; cl17715 279808007478 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808007479 MULE transposase domain; Region: MULE; pfam10551 279808007480 SAP domain; Region: SAP; pfam02037 279808007481 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808007482 MULE transposase domain; Region: MULE; pfam10551 279808007483 Transposase, Mutator family; Region: Transposase_mut; pfam00872 279808007484 MULE transposase domain; Region: MULE; pfam10551 279808007485 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 279808007486 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 279808007487 Int/Topo IB signature motif; other site 279808007488 GMP synthase; Reviewed; Region: guaA; PRK00074 279808007489 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 279808007490 AMP/PPi binding site [chemical binding]; other site 279808007491 candidate oxyanion hole; other site 279808007492 catalytic triad [active] 279808007493 potential glutamine specificity residues [chemical binding]; other site 279808007494 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 279808007495 ATP Binding subdomain [chemical binding]; other site 279808007496 Ligand Binding sites [chemical binding]; other site 279808007497 Dimerization subdomain; other site 279808007498 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 279808007499 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 279808007500 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 279808007501 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 279808007502 active site 279808007503 xanthine permease; Region: pbuX; TIGR03173 279808007504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 279808007505 active site 279808007506 putative mechanosensitive channel protein; Provisional; Region: PRK10929 279808007507 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 279808007508 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 279808007509 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 279808007510 dimer interface [polypeptide binding]; other site 279808007511 FMN binding site [chemical binding]; other site 279808007512 NADPH bind site [chemical binding]; other site 279808007513 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 279808007514 peroxiredoxin; Region: AhpC; TIGR03137 279808007515 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 279808007516 dimer interface [polypeptide binding]; other site 279808007517 decamer (pentamer of dimers) interface [polypeptide binding]; other site 279808007518 catalytic triad [active] 279808007519 peroxidatic and resolving cysteines [active] 279808007520 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 279808007521 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 279808007522 catalytic residue [active] 279808007523 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 279808007524 catalytic residues [active] 279808007525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 279808007526 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 279808007527 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 279808007528 catalytic core [active] 279808007529 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 279808007530 Transposase IS200 like; Region: Y1_Tnp; pfam01797 279808007531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 279808007532 Coenzyme A binding pocket [chemical binding]; other site 279808007533 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 279808007534 active site 279808007535 NTP binding site [chemical binding]; other site 279808007536 metal binding triad [ion binding]; metal-binding site 279808007537 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 279808007538 Helix-turn-helix domain; Region: HTH_28; pfam13518 279808007539 Winged helix-turn helix; Region: HTH_29; pfam13551 279808007540 Homeodomain-like domain; Region: HTH_32; pfam13565 279808007541 Integrase core domain; Region: rve; pfam00665 279808007542 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 279808007543 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 279808007544 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 279808007545 catalytic residues [active] 279808007546 catalytic nucleophile [active] 279808007547 Presynaptic Site I dimer interface [polypeptide binding]; other site 279808007548 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 279808007549 Synaptic Flat tetramer interface [polypeptide binding]; other site 279808007550 Synaptic Site I dimer interface [polypeptide binding]; other site 279808007551 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 279808007552 DNA-binding interface [nucleotide binding]; DNA binding site 279808007553 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 279808007554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808007555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808007556 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 279808007557 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 279808007558 Walker A/P-loop; other site 279808007559 ATP binding site [chemical binding]; other site 279808007560 Q-loop/lid; other site 279808007561 ABC transporter signature motif; other site 279808007562 Walker B; other site 279808007563 D-loop; other site 279808007564 H-loop/switch region; other site 279808007565 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 279808007566 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 279808007567 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808007568 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808007569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 279808007570 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 279808007571 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 279808007572 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 279808007573 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808007574 Transposase; Region: DDE_Tnp_ISL3; pfam01610 279808007575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 279808007576 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 279808007577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 279808007578 salt bridge; other site 279808007579 non-specific DNA binding site [nucleotide binding]; other site 279808007580 sequence-specific DNA binding site [nucleotide binding]; other site 279808007581 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 279808007582 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 279808007583 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 279808007584 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 279808007585 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 279808007586 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 279808007587 dimer interface [polypeptide binding]; other site 279808007588 ssDNA binding site [nucleotide binding]; other site 279808007589 tetramer (dimer of dimers) interface [polypeptide binding]; other site 279808007590 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 279808007591 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 279808007592 active site 279808007593 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 279808007594 GTP-binding protein YchF; Reviewed; Region: PRK09601 279808007595 YchF GTPase; Region: YchF; cd01900 279808007596 G1 box; other site 279808007597 GTP/Mg2+ binding site [chemical binding]; other site 279808007598 Switch I region; other site 279808007599 G2 box; other site 279808007600 Switch II region; other site 279808007601 G3 box; other site 279808007602 G4 box; other site 279808007603 G5 box; other site 279808007604 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 279808007605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 279808007606 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 279808007607 Mechanosensitive ion channel; Region: MS_channel; pfam00924 279808007608 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 279808007609 ParB-like nuclease domain; Region: ParB; smart00470 279808007610 cystathionine gamma-synthase; Reviewed; Region: PRK08247 279808007611 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279808007612 homodimer interface [polypeptide binding]; other site 279808007613 substrate-cofactor binding pocket; other site 279808007614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808007615 catalytic residue [active] 279808007616 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 279808007617 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 279808007618 homodimer interface [polypeptide binding]; other site 279808007619 substrate-cofactor binding pocket; other site 279808007620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 279808007621 catalytic residue [active] 279808007622 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 279808007623 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 279808007624 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 279808007625 FAD binding site [chemical binding]; other site 279808007626 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 279808007627 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 279808007628 THF binding site; other site 279808007629 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 279808007630 substrate binding site [chemical binding]; other site 279808007631 THF binding site; other site 279808007632 zinc-binding site [ion binding]; other site 279808007633 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 279808007634 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 279808007635 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 279808007636 active site 279808007637 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 279808007638 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808007639 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808007640 ABC transporter; Region: ABC_tran_2; pfam12848 279808007641 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 279808007642 DinB superfamily; Region: DinB_2; pfam12867 279808007643 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 279808007644 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 279808007645 beta-D-glucuronidase; Provisional; Region: PRK10150 279808007646 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 279808007647 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 279808007648 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 279808007649 D-mannonate oxidoreductase; Provisional; Region: PRK08277 279808007650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 279808007651 NAD(P) binding site [chemical binding]; other site 279808007652 active site 279808007653 mannonate dehydratase; Provisional; Region: PRK03906 279808007654 mannonate dehydratase; Region: uxuA; TIGR00695 279808007655 glucuronate isomerase; Reviewed; Region: PRK02925 279808007656 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 279808007657 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 279808007658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808007659 putative substrate translocation pore; other site 279808007660 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 279808007661 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 279808007662 substrate binding site [chemical binding]; other site 279808007663 ATP binding site [chemical binding]; other site 279808007664 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 279808007665 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 279808007666 active site 279808007667 intersubunit interface [polypeptide binding]; other site 279808007668 catalytic residue [active] 279808007669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279808007670 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 279808007671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 279808007672 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 279808007673 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 279808007674 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 279808007675 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 279808007676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 279808007677 Walker A/P-loop; other site 279808007678 ATP binding site [chemical binding]; other site 279808007679 Q-loop/lid; other site 279808007680 ABC transporter signature motif; other site 279808007681 Walker B; other site 279808007682 D-loop; other site 279808007683 H-loop/switch region; other site 279808007684 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 279808007685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808007686 dimer interface [polypeptide binding]; other site 279808007687 conserved gate region; other site 279808007688 ABC-ATPase subunit interface; other site 279808007689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 279808007690 putative PBP binding loops; other site 279808007691 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 279808007692 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 279808007693 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 279808007694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 279808007695 Predicted membrane protein [Function unknown]; Region: COG4640 279808007696 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 279808007697 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 279808007698 Double zinc ribbon; Region: DZR; pfam12773 279808007699 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 279808007700 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279808007701 Catalytic site [active] 279808007702 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 279808007703 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 279808007704 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 279808007705 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 279808007706 Walker A/P-loop; other site 279808007707 ATP binding site [chemical binding]; other site 279808007708 Q-loop/lid; other site 279808007709 ABC transporter signature motif; other site 279808007710 Walker B; other site 279808007711 D-loop; other site 279808007712 H-loop/switch region; other site 279808007713 FtsX-like permease family; Region: FtsX; pfam02687 279808007714 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 279808007715 T surface-antigen of pili; Region: FctA; pfam12892 279808007716 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 279808007717 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 279808007718 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 279808007719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 279808007720 non-specific DNA binding site [nucleotide binding]; other site 279808007721 salt bridge; other site 279808007722 sequence-specific DNA binding site [nucleotide binding]; other site 279808007723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 279808007724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 279808007725 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 279808007726 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 279808007727 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 279808007728 ParB-like nuclease domain; Region: ParBc; pfam02195 279808007729 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 279808007730 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 279808007731 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 279808007732 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 279808007733 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 279808007734 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 279808007735 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 279808007736 trmE is a tRNA modification GTPase; Region: trmE; cd04164 279808007737 G1 box; other site 279808007738 GTP/Mg2+ binding site [chemical binding]; other site 279808007739 Switch I region; other site 279808007740 G2 box; other site 279808007741 Switch II region; other site 279808007742 G3 box; other site 279808007743 G4 box; other site 279808007744 G5 box; other site 279808007745 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 279808007746 ribonuclease P; Reviewed; Region: rnpA; PRK00499 279808007747 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 279808007748 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 279808007749 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 279808007750 active site 279808007751 metal binding site [ion binding]; metal-binding site 279808007752 Replication protein; Region: Rep_1; pfam01446 279808007753 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 279808007754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 279808007755 S-adenosylmethionine binding site [chemical binding]; other site 279808007756 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 279808007757 putative switch regulator; other site 279808007758 non-specific DNA interactions [nucleotide binding]; other site 279808007759 DNA binding site [nucleotide binding] 279808007760 sequence specific DNA binding site [nucleotide binding]; other site 279808007761 putative cAMP binding site [chemical binding]; other site 279808007762 Initiator Replication protein; Region: Rep_3; pfam01051 279808007763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 279808007764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 279808007765 putative substrate translocation pore; other site 279808007766 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 279808007767 MarR family; Region: MarR; pfam01047 279808007768 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 279808007769 Cytochrome P450; Region: p450; cl12078 279808007770 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 279808007771 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432