-- dump date   	20140620_080233
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
342451000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
342451000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
342451000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451000004	Walker A motif; other site
342451000005	ATP binding site [chemical binding]; other site
342451000006	Walker B motif; other site
342451000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
342451000008	arginine finger; other site
342451000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
342451000010	DnaA box-binding interface [nucleotide binding]; other site
342451000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
342451000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
342451000013	putative DNA binding surface [nucleotide binding]; other site
342451000014	dimer interface [polypeptide binding]; other site
342451000015	beta-clamp/clamp loader binding surface; other site
342451000016	beta-clamp/translesion DNA polymerase binding surface; other site
342451000017	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
342451000018	recombination protein F; Reviewed; Region: recF; PRK00064
342451000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
342451000020	Walker A/P-loop; other site
342451000021	ATP binding site [chemical binding]; other site
342451000022	Q-loop/lid; other site
342451000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451000024	ABC transporter signature motif; other site
342451000025	Walker B; other site
342451000026	D-loop; other site
342451000027	H-loop/switch region; other site
342451000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
342451000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451000030	Mg2+ binding site [ion binding]; other site
342451000031	G-X-G motif; other site
342451000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
342451000033	anchoring element; other site
342451000034	dimer interface [polypeptide binding]; other site
342451000035	ATP binding site [chemical binding]; other site
342451000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
342451000037	active site
342451000038	putative metal-binding site [ion binding]; other site
342451000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
342451000040	DNA gyrase subunit A; Validated; Region: PRK05560
342451000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
342451000042	CAP-like domain; other site
342451000043	active site
342451000044	primary dimer interface [polypeptide binding]; other site
342451000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342451000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342451000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342451000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342451000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342451000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342451000051	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
342451000052	putative substrate binding site [chemical binding]; other site
342451000053	putative ATP binding site [chemical binding]; other site
342451000054	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
342451000055	active sites [active]
342451000056	tetramer interface [polypeptide binding]; other site
342451000057	seryl-tRNA synthetase; Provisional; Region: PRK05431
342451000058	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
342451000059	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
342451000060	dimer interface [polypeptide binding]; other site
342451000061	active site
342451000062	motif 1; other site
342451000063	motif 2; other site
342451000064	motif 3; other site
342451000065	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
342451000066	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
342451000067	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
342451000068	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
342451000069	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
342451000070	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
342451000071	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
342451000072	DHH family; Region: DHH; pfam01368
342451000073	DHHA1 domain; Region: DHHA1; pfam02272
342451000074	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
342451000075	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
342451000076	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
342451000077	replicative DNA helicase; Region: DnaB; TIGR00665
342451000078	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
342451000079	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
342451000080	Walker A motif; other site
342451000081	ATP binding site [chemical binding]; other site
342451000082	Walker B motif; other site
342451000083	DNA binding loops [nucleotide binding]
342451000084	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
342451000085	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
342451000086	GDP-binding site [chemical binding]; other site
342451000087	ACT binding site; other site
342451000088	IMP binding site; other site
342451000089	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
342451000090	glycosyltransferase, MGT family; Region: MGT; TIGR01426
342451000091	active site
342451000092	TDP-binding site; other site
342451000093	acceptor substrate-binding pocket; other site
342451000094	Transcriptional regulators [Transcription]; Region: MarR; COG1846
342451000095	MarR family; Region: MarR_2; pfam12802
342451000096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000097	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451000098	putative substrate translocation pore; other site
342451000099	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342451000100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451000101	active site
342451000102	phosphorylation site [posttranslational modification]
342451000103	intermolecular recognition site; other site
342451000104	dimerization interface [polypeptide binding]; other site
342451000105	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
342451000106	DNA binding site [nucleotide binding]
342451000107	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
342451000108	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
342451000109	dimerization interface [polypeptide binding]; other site
342451000110	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342451000111	putative active site [active]
342451000112	heme pocket [chemical binding]; other site
342451000113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
342451000114	dimer interface [polypeptide binding]; other site
342451000115	phosphorylation site [posttranslational modification]
342451000116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451000117	ATP binding site [chemical binding]; other site
342451000118	Mg2+ binding site [ion binding]; other site
342451000119	G-X-G motif; other site
342451000120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
342451000121	YycH protein; Region: YycH; pfam07435
342451000122	YycH protein; Region: YycI; cl02015
342451000123	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
342451000124	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
342451000125	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
342451000126	DNA methylase; Region: N6_N4_Mtase; pfam01555
342451000127	DNA methylase; Region: N6_N4_Mtase; cl17433
342451000128	DNA methylase; Region: N6_N4_Mtase; cl17433
342451000129	Initiator Replication protein; Region: Rep_3; pfam01051
342451000130	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
342451000131	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
342451000132	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
342451000133	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
342451000134	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
342451000135	catalytic residues [active]
342451000136	catalytic nucleophile [active]
342451000137	Presynaptic Site I dimer interface [polypeptide binding]; other site
342451000138	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
342451000139	Synaptic Flat tetramer interface [polypeptide binding]; other site
342451000140	Synaptic Site I dimer interface [polypeptide binding]; other site
342451000141	DNA binding site [nucleotide binding]
342451000142	Recombinase; Region: Recombinase; pfam07508
342451000143	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
342451000144	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
342451000145	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
342451000146	catalytic residues [active]
342451000147	catalytic nucleophile [active]
342451000148	Recombinase; Region: Recombinase; pfam07508
342451000149	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
342451000150	Domain of unknown function (DUF927); Region: DUF927; pfam06048
342451000151	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
342451000152	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
342451000153	active site
342451000154	DNA binding site [nucleotide binding]
342451000155	catalytic site [active]
342451000156	Phage associated DNA primase [General function prediction only]; Region: COG3378
342451000157	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
342451000158	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
342451000159	catalytic residues [active]
342451000160	catalytic nucleophile [active]
342451000161	Recombinase; Region: Recombinase; pfam07508
342451000162	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
342451000163	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
342451000164	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
342451000165	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
342451000166	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
342451000167	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
342451000168	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
342451000169	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
342451000170	HsdM N-terminal domain; Region: HsdM_N; pfam12161
342451000171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451000172	S-adenosylmethionine binding site [chemical binding]; other site
342451000173	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
342451000174	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
342451000175	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
342451000176	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342451000177	ATP binding site [chemical binding]; other site
342451000178	putative Mg++ binding site [ion binding]; other site
342451000179	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
342451000180	Predicted secreted protein [Function unknown]; Region: COG4086
342451000181	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
342451000182	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
342451000183	active site
342451000184	tetramer interface; other site
342451000185	Chain length determinant protein; Region: Wzz; cl15801
342451000186	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
342451000187	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
342451000188	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
342451000189	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
342451000190	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
342451000191	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
342451000192	NAD(P) binding site [chemical binding]; other site
342451000193	homodimer interface [polypeptide binding]; other site
342451000194	substrate binding site [chemical binding]; other site
342451000195	active site
342451000196	putative glycosyl transferase; Provisional; Region: PRK10073
342451000197	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
342451000198	active site
342451000199	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
342451000200	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
342451000201	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
342451000202	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342451000203	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
342451000204	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
342451000205	Bacterial sugar transferase; Region: Bac_transf; pfam02397
342451000206	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451000207	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
342451000208	active site
342451000209	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451000210	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
342451000211	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
342451000212	active site
342451000213	Part of AAA domain; Region: AAA_19; pfam13245
342451000214	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
342451000215	AAA domain; Region: AAA_12; pfam13087
342451000216	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
342451000217	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
342451000218	active site
342451000219	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
342451000220	hypothetical protein; Provisional; Region: PRK08317
342451000221	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451000222	S-adenosylmethionine binding site [chemical binding]; other site
342451000223	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
342451000224	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
342451000225	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
342451000226	acetolactate synthase; Reviewed; Region: PRK08617
342451000227	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
342451000228	PYR/PP interface [polypeptide binding]; other site
342451000229	dimer interface [polypeptide binding]; other site
342451000230	TPP binding site [chemical binding]; other site
342451000231	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
342451000232	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
342451000233	TPP-binding site [chemical binding]; other site
342451000234	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
342451000235	L-lactate permease; Region: Lactate_perm; cl00701
342451000236	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
342451000237	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451000238	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
342451000239	dimerization interface [polypeptide binding]; other site
342451000240	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451000241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000243	putative substrate translocation pore; other site
342451000244	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451000245	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
342451000246	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
342451000247	Anaphase-promoting complex subunit 9; Region: Apc9; pfam12856
342451000248	FtsX-like permease family; Region: FtsX; pfam02687
342451000249	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
342451000250	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
342451000251	Walker A/P-loop; other site
342451000252	ATP binding site [chemical binding]; other site
342451000253	Q-loop/lid; other site
342451000254	ABC transporter signature motif; other site
342451000255	Walker B; other site
342451000256	D-loop; other site
342451000257	H-loop/switch region; other site
342451000258	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
342451000259	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
342451000260	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
342451000261	active site
342451000262	non-prolyl cis peptide bond; other site
342451000263	NAD-dependent deacetylase; Provisional; Region: PRK00481
342451000264	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
342451000265	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
342451000266	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451000267	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
342451000268	trimer interface [polypeptide binding]; other site
342451000269	active site
342451000270	substrate binding site [chemical binding]; other site
342451000271	CoA binding site [chemical binding]; other site
342451000272	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
342451000273	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
342451000274	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
342451000275	Predicted amidohydrolase [General function prediction only]; Region: COG0388
342451000276	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
342451000277	Predicted amidohydrolase [General function prediction only]; Region: COG0388
342451000278	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
342451000279	active site
342451000280	catalytic triad [active]
342451000281	dimer interface [polypeptide binding]; other site
342451000282	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
342451000283	Predicted transcriptional regulators [Transcription]; Region: COG1733
342451000284	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
342451000285	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
342451000286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
342451000287	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342451000288	melibiose:sodium symporter; Provisional; Region: PRK10429
342451000289	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
342451000290	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
342451000291	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
342451000292	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
342451000293	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
342451000294	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
342451000295	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
342451000296	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
342451000297	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
342451000298	Ligand binding site; other site
342451000299	Putative Catalytic site; other site
342451000300	DXD motif; other site
342451000301	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
342451000302	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
342451000303	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
342451000304	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342451000305	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
342451000306	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451000307	non-specific DNA binding site [nucleotide binding]; other site
342451000308	salt bridge; other site
342451000309	sequence-specific DNA binding site [nucleotide binding]; other site
342451000310	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
342451000311	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
342451000312	short chain dehydrogenase; Provisional; Region: PRK07677
342451000313	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
342451000314	NAD(P) binding site [chemical binding]; other site
342451000315	substrate binding site [chemical binding]; other site
342451000316	homotetramer interface [polypeptide binding]; other site
342451000317	active site
342451000318	homodimer interface [polypeptide binding]; other site
342451000319	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342451000320	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451000321	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
342451000322	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
342451000323	N-acetyl-D-glucosamine binding site [chemical binding]; other site
342451000324	catalytic residue [active]
342451000325	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
342451000326	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
342451000327	N-acetyl-D-glucosamine binding site [chemical binding]; other site
342451000328	catalytic residue [active]
342451000329	RibD C-terminal domain; Region: RibD_C; cl17279
342451000330	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
342451000331	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
342451000332	dimer interface [polypeptide binding]; other site
342451000333	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
342451000334	dimer interface [polypeptide binding]; other site
342451000335	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
342451000336	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
342451000337	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
342451000338	putative active site [active]
342451000339	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
342451000340	active site turn [active]
342451000341	phosphorylation site [posttranslational modification]
342451000342	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
342451000343	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
342451000344	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
342451000345	HPr interaction site; other site
342451000346	glycerol kinase (GK) interaction site [polypeptide binding]; other site
342451000347	active site
342451000348	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
342451000349	active site
342451000350	phosphorylation site [posttranslational modification]
342451000351	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
342451000352	beta-galactosidase; Region: BGL; TIGR03356
342451000353	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
342451000354	active site
342451000355	Mn binding site [ion binding]; other site
342451000356	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
342451000357	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
342451000358	active site residue [active]
342451000359	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
342451000360	methionine sulfoxide reductase A; Provisional; Region: PRK05528
342451000361	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
342451000362	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
342451000363	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451000364	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
342451000365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451000366	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
342451000367	Walker A/P-loop; other site
342451000368	ATP binding site [chemical binding]; other site
342451000369	Q-loop/lid; other site
342451000370	ABC transporter signature motif; other site
342451000371	Walker B; other site
342451000372	D-loop; other site
342451000373	H-loop/switch region; other site
342451000374	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
342451000375	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
342451000376	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
342451000377	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
342451000378	Cna protein B-type domain; Region: Cna_B; pfam05738
342451000379	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
342451000380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451000381	Walker A/P-loop; other site
342451000382	ATP binding site [chemical binding]; other site
342451000383	Q-loop/lid; other site
342451000384	ABC transporter signature motif; other site
342451000385	Walker B; other site
342451000386	D-loop; other site
342451000387	H-loop/switch region; other site
342451000388	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
342451000389	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
342451000390	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451000391	MarR family; Region: MarR_2; pfam12802
342451000392	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
342451000393	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
342451000394	Predicted permeases [General function prediction only]; Region: COG0679
342451000395	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
342451000396	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
342451000397	Class III ribonucleotide reductase; Region: RNR_III; cd01675
342451000398	effector binding site; other site
342451000399	active site
342451000400	Zn binding site [ion binding]; other site
342451000401	glycine loop; other site
342451000402	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
342451000403	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
342451000404	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
342451000405	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
342451000406	active site
342451000407	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
342451000408	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
342451000409	Zn binding site [ion binding]; other site
342451000410	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
342451000411	Zn binding site [ion binding]; other site
342451000412	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451000413	sequence-specific DNA binding site [nucleotide binding]; other site
342451000414	salt bridge; other site
342451000415	Cupin domain; Region: Cupin_2; pfam07883
342451000416	Protein of unknown function (DUF418); Region: DUF418; cl12135
342451000417	Protein of unknown function (DUF418); Region: DUF418; pfam04235
342451000418	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
342451000419	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
342451000420	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
342451000421	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
342451000422	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
342451000423	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
342451000424	oligomerization interface [polypeptide binding]; other site
342451000425	active site
342451000426	metal binding site [ion binding]; metal-binding site
342451000427	pantoate--beta-alanine ligase; Region: panC; TIGR00018
342451000428	Pantoate-beta-alanine ligase; Region: PanC; cd00560
342451000429	active site
342451000430	ATP-binding site [chemical binding]; other site
342451000431	pantoate-binding site; other site
342451000432	HXXH motif; other site
342451000433	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
342451000434	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
342451000435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451000436	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
342451000437	DoxX-like family; Region: DoxX_2; pfam13564
342451000438	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
342451000439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000440	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
342451000441	putative substrate translocation pore; other site
342451000442	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
342451000443	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
342451000444	FMN binding site [chemical binding]; other site
342451000445	active site
342451000446	catalytic residues [active]
342451000447	substrate binding site [chemical binding]; other site
342451000448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000449	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451000450	putative substrate translocation pore; other site
342451000451	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451000452	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451000453	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
342451000454	putative dimerization interface [polypeptide binding]; other site
342451000455	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
342451000456	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
342451000457	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
342451000458	putative active site [active]
342451000459	catalytic site [active]
342451000460	putative metal binding site [ion binding]; other site
342451000461	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451000462	MarR family; Region: MarR_2; pfam12802
342451000463	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
342451000464	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
342451000465	dimer interface [polypeptide binding]; other site
342451000466	PYR/PP interface [polypeptide binding]; other site
342451000467	TPP binding site [chemical binding]; other site
342451000468	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
342451000469	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
342451000470	TPP-binding site [chemical binding]; other site
342451000471	dimer interface [polypeptide binding]; other site
342451000472	hypothetical protein; Provisional; Region: PRK04194
342451000473	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
342451000474	AIR carboxylase; Region: AIRC; smart01001
342451000475	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
342451000476	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
342451000477	Ligand Binding Site [chemical binding]; other site
342451000478	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
342451000479	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
342451000480	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
342451000481	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
342451000482	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
342451000483	pyruvate phosphate dikinase; Provisional; Region: PRK09279
342451000484	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
342451000485	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
342451000486	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
342451000487	PEP synthetase regulatory protein; Provisional; Region: PRK05339
342451000488	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
342451000489	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
342451000490	siderophore binding site; other site
342451000491	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
342451000492	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451000493	non-specific DNA binding site [nucleotide binding]; other site
342451000494	salt bridge; other site
342451000495	sequence-specific DNA binding site [nucleotide binding]; other site
342451000496	Cupin domain; Region: Cupin_2; pfam07883
342451000497	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
342451000498	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000499	putative substrate translocation pore; other site
342451000500	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
342451000501	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
342451000502	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
342451000503	putative active site [active]
342451000504	catalytic site [active]
342451000505	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
342451000506	putative active site [active]
342451000507	catalytic site [active]
342451000508	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
342451000509	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342451000510	DNA-binding site [nucleotide binding]; DNA binding site
342451000511	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342451000512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451000513	homodimer interface [polypeptide binding]; other site
342451000514	catalytic residue [active]
342451000515	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
342451000516	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
342451000517	inhibitor-cofactor binding pocket; inhibition site
342451000518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451000519	catalytic residue [active]
342451000520	succinic semialdehyde dehydrogenase; Region: PLN02278
342451000521	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
342451000522	tetramerization interface [polypeptide binding]; other site
342451000523	NAD(P) binding site [chemical binding]; other site
342451000524	catalytic residues [active]
342451000525	amino acid transporter; Region: 2A0306; TIGR00909
342451000526	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
342451000527	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
342451000528	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
342451000529	catalytic residue [active]
342451000530	Methyltransferase domain; Region: Methyltransf_31; pfam13847
342451000531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451000532	S-adenosylmethionine binding site [chemical binding]; other site
342451000533	BCCT family transporter; Region: BCCT; pfam02028
342451000534	Predicted transcriptional regulators [Transcription]; Region: COG1510
342451000535	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
342451000536	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
342451000537	tetramerization interface [polypeptide binding]; other site
342451000538	NAD(P) binding site [chemical binding]; other site
342451000539	catalytic residues [active]
342451000540	choline dehydrogenase; Validated; Region: PRK02106
342451000541	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
342451000542	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
342451000543	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451000544	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451000545	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
342451000546	dimerization interface [polypeptide binding]; other site
342451000547	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
342451000548	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
342451000549	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
342451000550	classical (c) SDRs; Region: SDR_c; cd05233
342451000551	NAD(P) binding site [chemical binding]; other site
342451000552	active site
342451000553	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012
342451000554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000555	putative substrate translocation pore; other site
342451000556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000557	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
342451000558	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
342451000559	active site
342451000560	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
342451000561	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
342451000562	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451000563	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
342451000564	Coenzyme A binding pocket [chemical binding]; other site
342451000565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000567	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
342451000568	dimer interface [polypeptide binding]; other site
342451000569	FMN binding site [chemical binding]; other site
342451000570	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
342451000571	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
342451000572	putative active site [active]
342451000573	putative metal binding site [ion binding]; other site
342451000574	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
342451000575	active site
342451000576	dimerization interface [polypeptide binding]; other site
342451000577	proline/glycine betaine transporter; Provisional; Region: PRK10642
342451000578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000579	putative substrate translocation pore; other site
342451000580	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
342451000581	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
342451000582	Walker A/P-loop; other site
342451000583	ATP binding site [chemical binding]; other site
342451000584	Q-loop/lid; other site
342451000585	ABC transporter signature motif; other site
342451000586	Walker B; other site
342451000587	D-loop; other site
342451000588	H-loop/switch region; other site
342451000589	fructuronate transporter; Provisional; Region: PRK10034; cl15264
342451000590	fructuronate transporter; Provisional; Region: PRK10034; cl15264
342451000591	fructuronate transporter; Provisional; Region: PRK10034; cl15264
342451000592	Amino acid permease; Region: AA_permease; pfam00324
342451000593	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
342451000594	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
342451000595	inhibitor-cofactor binding pocket; inhibition site
342451000596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451000597	catalytic residue [active]
342451000598	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
342451000599	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
342451000600	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
342451000601	heterotetramer interface [polypeptide binding]; other site
342451000602	active site pocket [active]
342451000603	cleavage site
342451000604	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
342451000605	nucleotide binding site [chemical binding]; other site
342451000606	N-acetyl-L-glutamate binding site [chemical binding]; other site
342451000607	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
342451000608	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
342451000609	metal binding site [ion binding]; metal-binding site
342451000610	dimer interface [polypeptide binding]; other site
342451000611	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
342451000612	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
342451000613	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
342451000614	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342451000615	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451000616	active site
342451000617	metal binding site [ion binding]; metal-binding site
342451000618	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
342451000619	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
342451000620	L-lactate permease; Region: Lactate_perm; cl00701
342451000621	polyol permease family; Region: 2A0118; TIGR00897
342451000622	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000623	putative substrate translocation pore; other site
342451000624	ornithine carbamoyltransferase; Validated; Region: PRK02102
342451000625	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
342451000626	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
342451000627	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
342451000628	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
342451000629	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
342451000630	PTS system arbutin-specific transporter subunit IIB; Provisional; Region: PRK09702
342451000631	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
342451000632	active site turn [active]
342451000633	phosphorylation site [posttranslational modification]
342451000634	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
342451000635	active site
342451000636	trimer interface [polypeptide binding]; other site
342451000637	allosteric site; other site
342451000638	active site lid [active]
342451000639	hexamer (dimer of trimers) interface [polypeptide binding]; other site
342451000640	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
342451000641	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
342451000642	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
342451000643	NAD binding site [chemical binding]; other site
342451000644	catalytic Zn binding site [ion binding]; other site
342451000645	substrate binding site [chemical binding]; other site
342451000646	structural Zn binding site [ion binding]; other site
342451000647	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
342451000648	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
342451000649	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
342451000650	active site
342451000651	P-loop; other site
342451000652	phosphorylation site [posttranslational modification]
342451000653	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
342451000654	active site
342451000655	methionine cluster; other site
342451000656	phosphorylation site [posttranslational modification]
342451000657	metal binding site [ion binding]; metal-binding site
342451000658	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
342451000659	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
342451000660	substrate binding pocket [chemical binding]; other site
342451000661	membrane-bound complex binding site; other site
342451000662	hinge residues; other site
342451000663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451000664	dimer interface [polypeptide binding]; other site
342451000665	conserved gate region; other site
342451000666	putative PBP binding loops; other site
342451000667	ABC-ATPase subunit interface; other site
342451000668	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
342451000669	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
342451000670	Walker A/P-loop; other site
342451000671	ATP binding site [chemical binding]; other site
342451000672	Q-loop/lid; other site
342451000673	ABC transporter signature motif; other site
342451000674	Walker B; other site
342451000675	D-loop; other site
342451000676	H-loop/switch region; other site
342451000677	HTH domain; Region: HTH_11; cl17392
342451000678	HTH domain; Region: HTH_11; cl17392
342451000679	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
342451000680	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
342451000681	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
342451000682	CAAX protease self-immunity; Region: Abi; pfam02517
342451000683	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
342451000684	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
342451000685	A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290
342451000686	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
342451000687	NAD binding site [chemical binding]; other site
342451000688	dimer interface [polypeptide binding]; other site
342451000689	tetramer (dimer of dimers) interface [polypeptide binding]; other site
342451000690	substrate binding site [chemical binding]; other site
342451000691	HTH domain; Region: HTH_11; pfam08279
342451000692	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
342451000693	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
342451000694	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
342451000695	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
342451000696	homodimer interface [polypeptide binding]; other site
342451000697	substrate-cofactor binding pocket; other site
342451000698	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451000699	catalytic residue [active]
342451000700	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
342451000701	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
342451000702	dimer interface [polypeptide binding]; other site
342451000703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451000704	catalytic residue [active]
342451000705	cystathionine beta-lyase; Provisional; Region: PRK07671
342451000706	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
342451000707	homodimer interface [polypeptide binding]; other site
342451000708	substrate-cofactor binding pocket; other site
342451000709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451000710	catalytic residue [active]
342451000711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000712	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451000713	putative substrate translocation pore; other site
342451000714	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342451000715	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451000716	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
342451000717	active site
342451000718	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
342451000719	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
342451000720	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
342451000721	UreF; Region: UreF; pfam01730
342451000722	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
342451000723	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
342451000724	dimer interface [polypeptide binding]; other site
342451000725	catalytic residues [active]
342451000726	urease subunit alpha; Reviewed; Region: ureC; PRK13207
342451000727	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
342451000728	subunit interactions [polypeptide binding]; other site
342451000729	active site
342451000730	flap region; other site
342451000731	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
342451000732	gamma-beta subunit interface [polypeptide binding]; other site
342451000733	alpha-beta subunit interface [polypeptide binding]; other site
342451000734	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
342451000735	alpha-gamma subunit interface [polypeptide binding]; other site
342451000736	beta-gamma subunit interface [polypeptide binding]; other site
342451000737	urea transporter, Yersinia type; Region: urea_trans_yut; TIGR03441
342451000738	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
342451000739	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
342451000740	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
342451000741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451000742	dimer interface [polypeptide binding]; other site
342451000743	conserved gate region; other site
342451000744	putative PBP binding loops; other site
342451000745	ABC-ATPase subunit interface; other site
342451000746	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
342451000747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451000748	dimer interface [polypeptide binding]; other site
342451000749	conserved gate region; other site
342451000750	putative PBP binding loops; other site
342451000751	ABC-ATPase subunit interface; other site
342451000752	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
342451000753	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
342451000754	Walker A/P-loop; other site
342451000755	ATP binding site [chemical binding]; other site
342451000756	Q-loop/lid; other site
342451000757	ABC transporter signature motif; other site
342451000758	Walker B; other site
342451000759	D-loop; other site
342451000760	H-loop/switch region; other site
342451000761	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
342451000762	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
342451000763	Walker A/P-loop; other site
342451000764	ATP binding site [chemical binding]; other site
342451000765	Q-loop/lid; other site
342451000766	ABC transporter signature motif; other site
342451000767	Walker B; other site
342451000768	D-loop; other site
342451000769	H-loop/switch region; other site
342451000770	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
342451000771	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
342451000772	intersubunit interface [polypeptide binding]; other site
342451000773	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451000774	MarR family; Region: MarR_2; pfam12802
342451000775	amino acid transporter; Region: 2A0306; TIGR00909
342451000776	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342451000777	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
342451000778	active site
342451000779	metal binding site [ion binding]; metal-binding site
342451000780	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
342451000781	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
342451000782	active site
342451000783	motif I; other site
342451000784	motif II; other site
342451000785	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
342451000786	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
342451000787	Ligand Binding Site [chemical binding]; other site
342451000788	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
342451000789	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
342451000790	quinone interaction residues [chemical binding]; other site
342451000791	active site
342451000792	catalytic residues [active]
342451000793	FMN binding site [chemical binding]; other site
342451000794	substrate binding site [chemical binding]; other site
342451000795	Phosphotransferase enzyme family; Region: APH; pfam01636
342451000796	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
342451000797	active site
342451000798	ATP binding site [chemical binding]; other site
342451000799	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
342451000800	substrate binding site [chemical binding]; other site
342451000801	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
342451000802	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
342451000803	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
342451000804	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
342451000805	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451000806	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
342451000807	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
342451000808	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
342451000809	active site
342451000810	tetramer interface [polypeptide binding]; other site
342451000811	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
342451000812	Peptidase family M23; Region: Peptidase_M23; pfam01551
342451000813	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
342451000814	endonuclease III; Region: ENDO3c; smart00478
342451000815	minor groove reading motif; other site
342451000816	helix-hairpin-helix signature motif; other site
342451000817	active site
342451000818	Uncharacterized conserved protein [Function unknown]; Region: COG3189
342451000819	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
342451000820	active site
342451000821	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
342451000822	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
342451000823	transaminase; Reviewed; Region: PRK08068
342451000824	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342451000825	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451000826	homodimer interface [polypeptide binding]; other site
342451000827	catalytic residue [active]
342451000828	D-lactate dehydrogenase; Validated; Region: PRK08605
342451000829	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
342451000830	homodimer interface [polypeptide binding]; other site
342451000831	ligand binding site [chemical binding]; other site
342451000832	NAD binding site [chemical binding]; other site
342451000833	catalytic site [active]
342451000834	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
342451000835	metal-binding site [ion binding]
342451000836	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
342451000837	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
342451000838	metal-binding site [ion binding]
342451000839	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
342451000840	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
342451000841	metal-binding site [ion binding]
342451000842	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
342451000843	Soluble P-type ATPase [General function prediction only]; Region: COG4087
342451000844	high affinity sulphate transporter 1; Region: sulP; TIGR00815
342451000845	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
342451000846	Sulfate transporter family; Region: Sulfate_transp; pfam00916
342451000847	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
342451000848	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
342451000849	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
342451000850	Walker A/P-loop; other site
342451000851	ATP binding site [chemical binding]; other site
342451000852	Q-loop/lid; other site
342451000853	ABC transporter signature motif; other site
342451000854	Walker B; other site
342451000855	D-loop; other site
342451000856	H-loop/switch region; other site
342451000857	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
342451000858	FtsX-like permease family; Region: FtsX; pfam02687
342451000859	short chain dehydrogenase; Provisional; Region: PRK06701
342451000860	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451000861	NAD(P) binding site [chemical binding]; other site
342451000862	active site
342451000863	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
342451000864	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
342451000865	transmembrane helices; other site
342451000866	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
342451000867	Predicted integral membrane protein [Function unknown]; Region: COG5505
342451000868	maltose O-acetyltransferase; Provisional; Region: PRK10092
342451000869	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
342451000870	active site
342451000871	substrate binding site [chemical binding]; other site
342451000872	trimer interface [polypeptide binding]; other site
342451000873	CoA binding site [chemical binding]; other site
342451000874	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
342451000875	hypothetical protein; Provisional; Region: PRK05463
342451000876	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
342451000877	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
342451000878	Acyltransferase family; Region: Acyl_transf_3; pfam01757
342451000879	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
342451000880	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
342451000881	Glutamate binding site [chemical binding]; other site
342451000882	homodimer interface [polypeptide binding]; other site
342451000883	NAD binding site [chemical binding]; other site
342451000884	catalytic residues [active]
342451000885	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342451000886	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451000887	MMPL family; Region: MMPL; pfam03176
342451000888	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
342451000889	MMPL family; Region: MMPL; pfam03176
342451000890	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
342451000891	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
342451000892	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
342451000893	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
342451000894	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000895	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
342451000896	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
342451000897	metal binding site [ion binding]; metal-binding site
342451000898	dimer interface [polypeptide binding]; other site
342451000899	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
342451000900	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451000901	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451000902	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
342451000903	YrhK-like protein; Region: YrhK; pfam14145
342451000904	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
342451000905	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
342451000906	DNA binding site [nucleotide binding]
342451000907	active site
342451000908	BCCT family transporter; Region: BCCT; pfam02028
342451000909	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
342451000910	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
342451000911	dimer interface [polypeptide binding]; other site
342451000912	active site
342451000913	putative acyltransferase; Provisional; Region: PRK05790
342451000914	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
342451000915	dimer interface [polypeptide binding]; other site
342451000916	active site
342451000917	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
342451000918	homodimer interface [polypeptide binding]; other site
342451000919	catalytic residues [active]
342451000920	NAD binding site [chemical binding]; other site
342451000921	substrate binding pocket [chemical binding]; other site
342451000922	flexible flap; other site
342451000923	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
342451000924	Strictosidine synthase; Region: Str_synth; pfam03088
342451000925	Surface antigen [General function prediction only]; Region: COG3942
342451000926	CHAP domain; Region: CHAP; pfam05257
342451000927	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
342451000928	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451000929	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451000930	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
342451000931	putative dimerization interface [polypeptide binding]; other site
342451000932	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
342451000933	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
342451000934	pyruvate oxidase; Provisional; Region: PRK08611
342451000935	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
342451000936	PYR/PP interface [polypeptide binding]; other site
342451000937	tetramer interface [polypeptide binding]; other site
342451000938	dimer interface [polypeptide binding]; other site
342451000939	TPP binding site [chemical binding]; other site
342451000940	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
342451000941	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
342451000942	TPP-binding site [chemical binding]; other site
342451000943	Predicted membrane protein [Function unknown]; Region: COG1288
342451000944	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
342451000945	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342451000946	Helix-turn-helix domain; Region: HTH_38; pfam13936
342451000947	Homeodomain-like domain; Region: HTH_32; pfam13565
342451000948	Integrase core domain; Region: rve; pfam00665
342451000949	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
342451000950	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
342451000951	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
342451000952	active site turn [active]
342451000953	phosphorylation site [posttranslational modification]
342451000954	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
342451000955	HPr interaction site; other site
342451000956	glycerol kinase (GK) interaction site [polypeptide binding]; other site
342451000957	active site
342451000958	phosphorylation site [posttranslational modification]
342451000959	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
342451000960	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
342451000961	D-cysteine desulfhydrase; Validated; Region: PRK03910
342451000962	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
342451000963	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342451000964	catalytic residue [active]
342451000965	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
342451000966	active site
342451000967	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
342451000968	catalytic residues [active]
342451000969	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
342451000970	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451000971	Coenzyme A binding pocket [chemical binding]; other site
342451000972	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
342451000973	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
342451000974	EamA-like transporter family; Region: EamA; pfam00892
342451000975	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
342451000976	Cupin domain; Region: Cupin_2; pfam07883
342451000977	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342451000978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
342451000979	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
342451000980	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
342451000981	metal binding site [ion binding]; metal-binding site
342451000982	dimer interface [polypeptide binding]; other site
342451000983	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
342451000984	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342451000985	Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102
342451000986	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
342451000987	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
342451000988	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
342451000989	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
342451000990	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
342451000991	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
342451000992	inhibitor-cofactor binding pocket; inhibition site
342451000993	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451000994	catalytic residue [active]
342451000995	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
342451000996	substrate binding site; other site
342451000997	dimer interface; other site
342451000998	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
342451000999	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
342451001000	putative NAD(P) binding site [chemical binding]; other site
342451001001	putative catalytic Zn binding site [ion binding]; other site
342451001002	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
342451001003	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
342451001004	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
342451001005	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
342451001006	active site
342451001007	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
342451001008	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
342451001009	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
342451001010	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
342451001011	Walker A/P-loop; other site
342451001012	ATP binding site [chemical binding]; other site
342451001013	Q-loop/lid; other site
342451001014	ABC transporter signature motif; other site
342451001015	Walker B; other site
342451001016	D-loop; other site
342451001017	H-loop/switch region; other site
342451001018	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
342451001019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451001020	Walker A/P-loop; other site
342451001021	ATP binding site [chemical binding]; other site
342451001022	Q-loop/lid; other site
342451001023	ABC transporter signature motif; other site
342451001024	Walker B; other site
342451001025	D-loop; other site
342451001026	H-loop/switch region; other site
342451001027	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342451001028	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342451001029	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342451001030	DNA binding site [nucleotide binding]
342451001031	domain linker motif; other site
342451001032	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
342451001033	dimerization interface [polypeptide binding]; other site
342451001034	ligand binding site [chemical binding]; other site
342451001035	polyol permease family; Region: 2A0118; TIGR00897
342451001036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001037	putative substrate translocation pore; other site
342451001038	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
342451001039	N- and C-terminal domain interface [polypeptide binding]; other site
342451001040	D-xylulose kinase; Region: XylB; TIGR01312
342451001041	active site
342451001042	MgATP binding site [chemical binding]; other site
342451001043	catalytic site [active]
342451001044	metal binding site [ion binding]; metal-binding site
342451001045	xylulose binding site [chemical binding]; other site
342451001046	homodimer interface [polypeptide binding]; other site
342451001047	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
342451001048	L-idonate 5-dehydrogenase; Region: PLN02702
342451001049	inhibitor binding site; inhibition site
342451001050	catalytic Zn binding site [ion binding]; other site
342451001051	structural Zn binding site [ion binding]; other site
342451001052	NADP binding site [chemical binding]; other site
342451001053	tetramer interface [polypeptide binding]; other site
342451001054	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
342451001055	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451001056	motif II; other site
342451001057	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
342451001058	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
342451001059	metal binding site [ion binding]; metal-binding site
342451001060	dimer interface [polypeptide binding]; other site
342451001061	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
342451001062	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
342451001063	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451001064	Coenzyme A binding pocket [chemical binding]; other site
342451001065	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
342451001066	active site
342451001067	catalytic site [active]
342451001068	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
342451001069	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
342451001070	putative active site cavity [active]
342451001071	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
342451001072	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
342451001073	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
342451001074	putative active site [active]
342451001075	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
342451001076	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
342451001077	nucleotide binding site [chemical binding]; other site
342451001078	N-acetylneuraminate lyase; Provisional; Region: PRK04147
342451001079	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
342451001080	active site
342451001081	inhibitor site; inhibition site
342451001082	dimer interface [polypeptide binding]; other site
342451001083	catalytic residue [active]
342451001084	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
342451001085	putative transporter; Provisional; Region: PRK10484
342451001086	Na binding site [ion binding]; other site
342451001087	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
342451001088	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451001089	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
342451001090	active site
342451001091	motif I; other site
342451001092	motif II; other site
342451001093	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
342451001094	dimer interface [polypeptide binding]; other site
342451001095	FMN binding site [chemical binding]; other site
342451001096	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
342451001097	PRD domain; Region: PRD; pfam00874
342451001098	CAT RNA binding domain; Region: CAT_RBD; smart01061
342451001099	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
342451001100	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
342451001101	putative metal binding site [ion binding]; other site
342451001102	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342451001103	active site
342451001104	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
342451001105	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
342451001106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451001107	Walker A/P-loop; other site
342451001108	ATP binding site [chemical binding]; other site
342451001109	Q-loop/lid; other site
342451001110	ABC transporter signature motif; other site
342451001111	Walker B; other site
342451001112	D-loop; other site
342451001113	H-loop/switch region; other site
342451001114	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
342451001115	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
342451001116	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
342451001117	Walker A/P-loop; other site
342451001118	ATP binding site [chemical binding]; other site
342451001119	Q-loop/lid; other site
342451001120	ABC transporter signature motif; other site
342451001121	Walker B; other site
342451001122	D-loop; other site
342451001123	H-loop/switch region; other site
342451001124	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451001125	Coenzyme A binding pocket [chemical binding]; other site
342451001126	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
342451001127	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
342451001128	intersubunit interface [polypeptide binding]; other site
342451001129	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
342451001130	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
342451001131	NAD binding site [chemical binding]; other site
342451001132	catalytic residues [active]
342451001133	substrate binding site [chemical binding]; other site
342451001134	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451001135	MarR family; Region: MarR; pfam01047
342451001136	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
342451001137	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
342451001138	Zn binding site [ion binding]; other site
342451001139	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
342451001140	Zn binding site [ion binding]; other site
342451001141	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
342451001142	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
342451001143	Zn binding site [ion binding]; other site
342451001144	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
342451001145	Zn binding site [ion binding]; other site
342451001146	Predicted esterase [General function prediction only]; Region: COG0400
342451001147	Isochorismatase family; Region: Isochorismatase; pfam00857
342451001148	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
342451001149	catalytic triad [active]
342451001150	conserved cis-peptide bond; other site
342451001151	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
342451001152	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
342451001153	transmembrane helices; other site
342451001154	Uncharacterized membrane protein [Function unknown]; Region: COG3949
342451001155	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
342451001156	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
342451001157	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
342451001158	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
342451001159	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
342451001160	Na binding site [ion binding]; other site
342451001161	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
342451001162	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
342451001163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001164	D-galactonate transporter; Region: 2A0114; TIGR00893
342451001165	putative substrate translocation pore; other site
342451001166	Uncharacterized conserved protein [Function unknown]; Region: COG1359
342451001167	Predicted membrane protein [Function unknown]; Region: COG1289
342451001168	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
342451001169	Cgr1 family; Region: Cgr1; pfam03879
342451001170	TolA protein; Region: tolA_full; TIGR02794
342451001171	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
342451001172	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
342451001173	synthetase active site [active]
342451001174	NTP binding site [chemical binding]; other site
342451001175	metal binding site [ion binding]; metal-binding site
342451001176	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
342451001177	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
342451001178	DNA binding residues [nucleotide binding]
342451001179	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
342451001180	Transcriptional regulators [Transcription]; Region: GntR; COG1802
342451001181	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342451001182	DNA-binding site [nucleotide binding]; DNA binding site
342451001183	FCD domain; Region: FCD; pfam07729
342451001184	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
342451001185	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
342451001186	N- and C-terminal domain interface [polypeptide binding]; other site
342451001187	active site
342451001188	catalytic site [active]
342451001189	metal binding site [ion binding]; metal-binding site
342451001190	carbohydrate binding site [chemical binding]; other site
342451001191	ATP binding site [chemical binding]; other site
342451001192	fructuronate transporter; Provisional; Region: PRK10034; cl15264
342451001193	gluconate transporter; Region: gntP; TIGR00791
342451001194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451001195	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
342451001196	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451001197	NAD(P) binding site [chemical binding]; other site
342451001198	active site
342451001199	Uncharacterized membrane protein [Function unknown]; Region: COG3949
342451001200	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
342451001201	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
342451001202	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451001203	NAD(P) binding site [chemical binding]; other site
342451001204	active site
342451001205	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
342451001206	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
342451001207	Coenzyme A binding pocket [chemical binding]; other site
342451001208	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
342451001209	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
342451001210	dimer interface [polypeptide binding]; other site
342451001211	putative metal binding site [ion binding]; other site
342451001212	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
342451001213	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
342451001214	intersubunit interface [polypeptide binding]; other site
342451001215	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
342451001216	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
342451001217	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
342451001218	metal binding site [ion binding]; metal-binding site
342451001219	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
342451001220	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
342451001221	substrate binding site [chemical binding]; other site
342451001222	glutamase interaction surface [polypeptide binding]; other site
342451001223	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
342451001224	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
342451001225	catalytic residues [active]
342451001226	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
342451001227	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
342451001228	putative active site [active]
342451001229	oxyanion strand; other site
342451001230	catalytic triad [active]
342451001231	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
342451001232	putative active site pocket [active]
342451001233	4-fold oligomerization interface [polypeptide binding]; other site
342451001234	metal binding residues [ion binding]; metal-binding site
342451001235	3-fold/trimer interface [polypeptide binding]; other site
342451001236	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
342451001237	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342451001238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451001239	homodimer interface [polypeptide binding]; other site
342451001240	catalytic residue [active]
342451001241	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
342451001242	histidinol dehydrogenase; Region: hisD; TIGR00069
342451001243	NAD binding site [chemical binding]; other site
342451001244	dimerization interface [polypeptide binding]; other site
342451001245	product binding site; other site
342451001246	substrate binding site [chemical binding]; other site
342451001247	zinc binding site [ion binding]; other site
342451001248	catalytic residues [active]
342451001249	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
342451001250	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
342451001251	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
342451001252	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
342451001253	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
342451001254	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342451001255	catalytic residue [active]
342451001256	polyphosphate kinase; Provisional; Region: PRK05443
342451001257	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
342451001258	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
342451001259	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
342451001260	putative domain interface [polypeptide binding]; other site
342451001261	putative active site [active]
342451001262	catalytic site [active]
342451001263	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
342451001264	putative domain interface [polypeptide binding]; other site
342451001265	putative active site [active]
342451001266	catalytic site [active]
342451001267	exopolyphosphatase; Region: exo_poly_only; TIGR03706
342451001268	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
342451001269	AbgT putative transporter family; Region: ABG_transport; cl17431
342451001270	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
342451001271	short chain dehydrogenase; Validated; Region: PRK08589
342451001272	classical (c) SDRs; Region: SDR_c; cd05233
342451001273	NAD(P) binding site [chemical binding]; other site
342451001274	active site
342451001275	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
342451001276	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
342451001277	oligomer interface [polypeptide binding]; other site
342451001278	active site
342451001279	metal binding site [ion binding]; metal-binding site
342451001280	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
342451001281	catalytic residues [active]
342451001282	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
342451001283	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
342451001284	active site
342451001285	FMN binding site [chemical binding]; other site
342451001286	substrate binding site [chemical binding]; other site
342451001287	3Fe-4S cluster binding site [ion binding]; other site
342451001288	CAAX protease self-immunity; Region: Abi; pfam02517
342451001289	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
342451001290	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451001291	Walker A/P-loop; other site
342451001292	ATP binding site [chemical binding]; other site
342451001293	Q-loop/lid; other site
342451001294	ABC transporter signature motif; other site
342451001295	Walker B; other site
342451001296	D-loop; other site
342451001297	H-loop/switch region; other site
342451001298	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
342451001299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001300	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451001301	putative substrate translocation pore; other site
342451001302	amino acid transporter; Region: 2A0306; TIGR00909
342451001303	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
342451001304	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
342451001305	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342451001306	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451001307	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
342451001308	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
342451001309	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
342451001310	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
342451001311	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
342451001312	active site
342451001313	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
342451001314	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
342451001315	Walker A/P-loop; other site
342451001316	ATP binding site [chemical binding]; other site
342451001317	Q-loop/lid; other site
342451001318	ABC transporter signature motif; other site
342451001319	Walker B; other site
342451001320	D-loop; other site
342451001321	H-loop/switch region; other site
342451001322	FOG: CBS domain [General function prediction only]; Region: COG0517
342451001323	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
342451001324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451001325	dimer interface [polypeptide binding]; other site
342451001326	conserved gate region; other site
342451001327	putative PBP binding loops; other site
342451001328	ABC-ATPase subunit interface; other site
342451001329	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
342451001330	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
342451001331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451001332	dimer interface [polypeptide binding]; other site
342451001333	conserved gate region; other site
342451001334	ABC-ATPase subunit interface; other site
342451001335	Predicted esterase [General function prediction only]; Region: COG0627
342451001336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
342451001337	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
342451001338	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
342451001339	active site
342451001340	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
342451001341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451001342	dimer interface [polypeptide binding]; other site
342451001343	conserved gate region; other site
342451001344	putative PBP binding loops; other site
342451001345	ABC-ATPase subunit interface; other site
342451001346	NMT1-like family; Region: NMT1_2; pfam13379
342451001347	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
342451001348	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
342451001349	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
342451001350	Walker A/P-loop; other site
342451001351	ATP binding site [chemical binding]; other site
342451001352	Q-loop/lid; other site
342451001353	ABC transporter signature motif; other site
342451001354	Walker B; other site
342451001355	D-loop; other site
342451001356	H-loop/switch region; other site
342451001357	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
342451001358	antiholin-like protein LrgB; Provisional; Region: PRK04288
342451001359	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
342451001360	two-component response regulator; Provisional; Region: PRK14084
342451001361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451001362	active site
342451001363	phosphorylation site [posttranslational modification]
342451001364	intermolecular recognition site; other site
342451001365	dimerization interface [polypeptide binding]; other site
342451001366	LytTr DNA-binding domain; Region: LytTR; smart00850
342451001367	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
342451001368	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
342451001369	GAF domain; Region: GAF_3; pfam13492
342451001370	Histidine kinase; Region: His_kinase; pfam06580
342451001371	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451001372	ATP binding site [chemical binding]; other site
342451001373	Mg2+ binding site [ion binding]; other site
342451001374	G-X-G motif; other site
342451001375	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451001376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001377	putative substrate translocation pore; other site
342451001378	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
342451001379	putative metal binding site [ion binding]; other site
342451001380	putative dimer interface [polypeptide binding]; other site
342451001381	Protein of unknown function (DUF805); Region: DUF805; cl01224
342451001382	Protein of unknown function (DUF969); Region: DUF969; cl01573
342451001383	Protein of unknown function (DUF969); Region: DUF969; cl01573
342451001384	Predicted membrane protein [Function unknown]; Region: COG3817
342451001385	Protein of unknown function (DUF979); Region: DUF979; pfam06166
342451001386	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
342451001387	putative substrate binding pocket [chemical binding]; other site
342451001388	AC domain interface; other site
342451001389	catalytic triad [active]
342451001390	AB domain interface; other site
342451001391	interchain disulfide; other site
342451001392	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
342451001393	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
342451001394	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
342451001395	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
342451001396	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
342451001397	putative phosphoesterase; Region: acc_ester; TIGR03729
342451001398	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
342451001399	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
342451001400	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
342451001401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001402	putative substrate translocation pore; other site
342451001403	Predicted membrane protein [Function unknown]; Region: COG2246
342451001404	GtrA-like protein; Region: GtrA; pfam04138
342451001405	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
342451001406	Cation efflux family; Region: Cation_efflux; cl00316
342451001407	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
342451001408	catalytic core [active]
342451001409	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
342451001410	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451001411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001412	putative substrate translocation pore; other site
342451001413	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
342451001414	FemAB family; Region: FemAB; pfam02388
342451001415	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
342451001416	Thioredoxin; Region: Thioredoxin_4; pfam13462
342451001417	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
342451001418	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
342451001419	intersubunit interface [polypeptide binding]; other site
342451001420	YodA lipocalin-like domain; Region: YodA; pfam09223
342451001421	Uncharacterized conserved protein [Function unknown]; Region: COG2353
342451001422	Predicted transcriptional regulators [Transcription]; Region: COG1695
342451001423	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
342451001424	hypothetical protein; Provisional; Region: PRK07758
342451001425	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
342451001426	putative hydrophobic ligand binding site [chemical binding]; other site
342451001427	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
342451001428	Predicted transcriptional regulator [Transcription]; Region: COG1959
342451001429	Transcriptional regulator; Region: Rrf2; pfam02082
342451001430	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
342451001431	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
342451001432	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451001433	Coenzyme A binding pocket [chemical binding]; other site
342451001434	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
342451001435	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
342451001436	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
342451001437	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
342451001438	putative dimer interface [polypeptide binding]; other site
342451001439	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
342451001440	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
342451001441	putative dimer interface [polypeptide binding]; other site
342451001442	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451001443	MarR family; Region: MarR_2; cl17246
342451001444	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
342451001445	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
342451001446	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
342451001447	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
342451001448	Helix-turn-helix domain; Region: HTH_18; pfam12833
342451001449	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
342451001450	amidase catalytic site [active]
342451001451	Zn binding residues [ion binding]; other site
342451001452	substrate binding site [chemical binding]; other site
342451001453	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
342451001454	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
342451001455	active site turn [active]
342451001456	phosphorylation site [posttranslational modification]
342451001457	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
342451001458	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
342451001459	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
342451001460	Cl binding site [ion binding]; other site
342451001461	oligomer interface [polypeptide binding]; other site
342451001462	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
342451001463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451001464	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
342451001465	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
342451001466	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
342451001467	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
342451001468	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
342451001469	PhoU domain; Region: PhoU; pfam01895
342451001470	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
342451001471	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451001472	NAD(P) binding site [chemical binding]; other site
342451001473	active site
342451001474	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
342451001475	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
342451001476	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
342451001477	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
342451001478	active site
342451001479	non-prolyl cis peptide bond; other site
342451001480	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
342451001481	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
342451001482	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
342451001483	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
342451001484	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
342451001485	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
342451001486	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256
342451001487	putative NAD(P) binding site [chemical binding]; other site
342451001488	catalytic Zn binding site [ion binding]; other site
342451001489	structural Zn binding site [ion binding]; other site
342451001490	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
342451001491	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
342451001492	DAK2 domain; Region: Dak2; pfam02734
342451001493	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
342451001494	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
342451001495	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
342451001496	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
342451001497	intersubunit interface [polypeptide binding]; other site
342451001498	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
342451001499	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
342451001500	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451001501	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451001502	Coenzyme A binding pocket [chemical binding]; other site
342451001503	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
342451001504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001505	putative substrate translocation pore; other site
342451001506	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
342451001507	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
342451001508	NAD(P) binding site [chemical binding]; other site
342451001509	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
342451001510	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451001511	Coenzyme A binding pocket [chemical binding]; other site
342451001512	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
342451001513	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
342451001514	L-lactate permease; Region: Lactate_perm; cl00701
342451001515	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
342451001516	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
342451001517	putative ADP-binding pocket [chemical binding]; other site
342451001518	malate:quinone oxidoreductase; Validated; Region: PRK05257
342451001519	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
342451001520	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342451001521	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
342451001522	dimerization interface [polypeptide binding]; other site
342451001523	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
342451001524	dimer interface [polypeptide binding]; other site
342451001525	phosphorylation site [posttranslational modification]
342451001526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451001527	ATP binding site [chemical binding]; other site
342451001528	Mg2+ binding site [ion binding]; other site
342451001529	G-X-G motif; other site
342451001530	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342451001531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451001532	active site
342451001533	phosphorylation site [posttranslational modification]
342451001534	intermolecular recognition site; other site
342451001535	dimerization interface [polypeptide binding]; other site
342451001536	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
342451001537	DNA binding site [nucleotide binding]
342451001538	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
342451001539	FtsX-like permease family; Region: FtsX; pfam02687
342451001540	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
342451001541	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
342451001542	Walker A/P-loop; other site
342451001543	ATP binding site [chemical binding]; other site
342451001544	Q-loop/lid; other site
342451001545	ABC transporter signature motif; other site
342451001546	Walker B; other site
342451001547	D-loop; other site
342451001548	H-loop/switch region; other site
342451001549	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
342451001550	putative active site [active]
342451001551	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451001552	MarR family; Region: MarR_2; pfam12802
342451001553	Predicted membrane protein [Function unknown]; Region: COG4640
342451001554	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
342451001555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001556	putative substrate translocation pore; other site
342451001557	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
342451001558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451001559	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
342451001560	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
342451001561	lipoyl-biotinyl attachment site [posttranslational modification]; other site
342451001562	HlyD family secretion protein; Region: HlyD_3; pfam13437
342451001563	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
342451001564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001565	putative substrate translocation pore; other site
342451001566	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
342451001567	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
342451001568	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
342451001569	active site
342451001570	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
342451001571	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
342451001572	oligomer interface [polypeptide binding]; other site
342451001573	metal binding site [ion binding]; metal-binding site
342451001574	metal binding site [ion binding]; metal-binding site
342451001575	putative Cl binding site [ion binding]; other site
342451001576	aspartate ring; other site
342451001577	basic sphincter; other site
342451001578	hydrophobic gate; other site
342451001579	periplasmic entrance; other site
342451001580	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
342451001581	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
342451001582	homotetramer interface [polypeptide binding]; other site
342451001583	FMN binding site [chemical binding]; other site
342451001584	homodimer contacts [polypeptide binding]; other site
342451001585	putative active site [active]
342451001586	putative substrate binding site [chemical binding]; other site
342451001587	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
342451001588	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
342451001589	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
342451001590	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
342451001591	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
342451001592	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
342451001593	active site
342451001594	DNA binding site [nucleotide binding]
342451001595	Protein of unknown function (DUF805); Region: DUF805; pfam05656
342451001596	ribulokinase; Provisional; Region: PRK04123
342451001597	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
342451001598	N- and C-terminal domain interface [polypeptide binding]; other site
342451001599	active site
342451001600	MgATP binding site [chemical binding]; other site
342451001601	catalytic site [active]
342451001602	metal binding site [ion binding]; metal-binding site
342451001603	carbohydrate binding site [chemical binding]; other site
342451001604	homodimer interface [polypeptide binding]; other site
342451001605	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
342451001606	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451001607	Walker A/P-loop; other site
342451001608	ATP binding site [chemical binding]; other site
342451001609	Q-loop/lid; other site
342451001610	ABC transporter signature motif; other site
342451001611	Walker B; other site
342451001612	D-loop; other site
342451001613	H-loop/switch region; other site
342451001614	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
342451001615	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
342451001616	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
342451001617	active site
342451001618	catalytic residues [active]
342451001619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
342451001620	MOSC domain; Region: MOSC; pfam03473
342451001621	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
342451001622	tetramer (dimer of dimers) interface [polypeptide binding]; other site
342451001623	active site
342451001624	dimer interface [polypeptide binding]; other site
342451001625	CAAX protease self-immunity; Region: Abi; pfam02517
342451001626	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
342451001627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451001628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451001629	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
342451001630	dimerization interface [polypeptide binding]; other site
342451001631	urocanate hydratase; Provisional; Region: PRK05414
342451001632	imidazolonepropionase; Validated; Region: PRK09356
342451001633	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
342451001634	active site
342451001635	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
342451001636	Sulfate transporter family; Region: Sulfate_transp; pfam00916
342451001637	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
342451001638	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
342451001639	metal binding site [ion binding]; metal-binding site
342451001640	oxidoreductase; Provisional; Region: PRK07985
342451001641	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451001642	NAD(P) binding site [chemical binding]; other site
342451001643	active site
342451001644	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
342451001645	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
342451001646	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
342451001647	putative hydrophobic ligand binding site [chemical binding]; other site
342451001648	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
342451001649	Helix-turn-helix domain; Region: HTH_28; pfam13518
342451001650	Integrase core domain; Region: rve; pfam00665
342451001651	Integrase core domain; Region: rve_2; pfam13333
342451001652	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
342451001653	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
342451001654	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
342451001655	putative active site [active]
342451001656	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
342451001657	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
342451001658	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
342451001659	active site turn [active]
342451001660	phosphorylation site [posttranslational modification]
342451001661	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
342451001662	Sodium Bile acid symporter family; Region: SBF; pfam01758
342451001663	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
342451001664	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
342451001665	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451001666	motif II; other site
342451001667	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
342451001668	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
342451001669	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
342451001670	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
342451001671	dimer interface [polypeptide binding]; other site
342451001672	active site
342451001673	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
342451001674	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
342451001675	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
342451001676	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
342451001677	putative active site [active]
342451001678	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
342451001679	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
342451001680	active site turn [active]
342451001681	phosphorylation site [posttranslational modification]
342451001682	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
342451001683	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
342451001684	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
342451001685	putative active site [active]
342451001686	Uncharacterized conserved protein [Function unknown]; Region: COG3589
342451001687	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
342451001688	Predicted transcriptional regulator [Transcription]; Region: COG2378
342451001689	HTH domain; Region: HTH_11; pfam08279
342451001690	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
342451001691	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
342451001692	active site
342451001693	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
342451001694	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
342451001695	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
342451001696	catalytic loop [active]
342451001697	iron binding site [ion binding]; other site
342451001698	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
342451001699	4Fe-4S binding domain; Region: Fer4_6; pfam12837
342451001700	4Fe-4S binding domain; Region: Fer4; pfam00037
342451001701	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
342451001702	[4Fe-4S] binding site [ion binding]; other site
342451001703	molybdopterin cofactor binding site; other site
342451001704	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
342451001705	molybdopterin cofactor binding site; other site
342451001706	Uncharacterized conserved protein [Function unknown]; Region: COG2427
342451001707	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
342451001708	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
342451001709	hypothetical protein; Provisional; Region: PRK06753
342451001710	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
342451001711	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
342451001712	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
342451001713	putative ligand binding site [chemical binding]; other site
342451001714	putative NAD binding site [chemical binding]; other site
342451001715	catalytic site [active]
342451001716	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
342451001717	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
342451001718	Surface antigen [General function prediction only]; Region: COG3942
342451001719	CHAP domain; Region: CHAP; pfam05257
342451001720	Tic20-like protein; Region: Tic20; pfam09685
342451001721	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
342451001722	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
342451001723	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
342451001724	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
342451001725	Surface antigen [General function prediction only]; Region: COG3942
342451001726	CHAP domain; Region: CHAP; cl17642
342451001727	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
342451001728	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
342451001729	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
342451001730	Transcriptional regulators [Transcription]; Region: MarR; COG1846
342451001731	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
342451001732	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
342451001733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451001734	dimer interface [polypeptide binding]; other site
342451001735	conserved gate region; other site
342451001736	putative PBP binding loops; other site
342451001737	ABC-ATPase subunit interface; other site
342451001738	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
342451001739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451001740	dimer interface [polypeptide binding]; other site
342451001741	conserved gate region; other site
342451001742	putative PBP binding loops; other site
342451001743	ABC-ATPase subunit interface; other site
342451001744	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
342451001745	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
342451001746	substrate binding pocket [chemical binding]; other site
342451001747	membrane-bound complex binding site; other site
342451001748	hinge residues; other site
342451001749	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
342451001750	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451001751	Walker A/P-loop; other site
342451001752	ATP binding site [chemical binding]; other site
342451001753	Q-loop/lid; other site
342451001754	ABC transporter signature motif; other site
342451001755	Walker B; other site
342451001756	D-loop; other site
342451001757	H-loop/switch region; other site
342451001758	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
342451001759	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
342451001760	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
342451001761	active site
342451001762	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
342451001763	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
342451001764	intersubunit interface [polypeptide binding]; other site
342451001765	BioY family; Region: BioY; pfam02632
342451001766	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
342451001767	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451001768	Coenzyme A binding pocket [chemical binding]; other site
342451001769	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
342451001770	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342451001771	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342451001772	DNA binding site [nucleotide binding]
342451001773	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
342451001774	putative dimerization interface [polypeptide binding]; other site
342451001775	putative ligand binding site [chemical binding]; other site
342451001776	galactokinase; Provisional; Region: PRK05322
342451001777	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
342451001778	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
342451001779	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
342451001780	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
342451001781	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
342451001782	NAD binding site [chemical binding]; other site
342451001783	homodimer interface [polypeptide binding]; other site
342451001784	active site
342451001785	substrate binding site [chemical binding]; other site
342451001786	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
342451001787	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
342451001788	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
342451001789	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
342451001790	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
342451001791	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
342451001792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451001793	dimer interface [polypeptide binding]; other site
342451001794	conserved gate region; other site
342451001795	putative PBP binding loops; other site
342451001796	ABC-ATPase subunit interface; other site
342451001797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451001798	Walker A/P-loop; other site
342451001799	ATP binding site [chemical binding]; other site
342451001800	ABC transporter; Region: ABC_tran; pfam00005
342451001801	Q-loop/lid; other site
342451001802	ABC transporter signature motif; other site
342451001803	Walker B; other site
342451001804	D-loop; other site
342451001805	H-loop/switch region; other site
342451001806	putative hydrolase; Provisional; Region: PRK02113
342451001807	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
342451001808	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
342451001809	Predicted transcriptional regulators [Transcription]; Region: COG1510
342451001810	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
342451001811	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
342451001812	ATP binding site [chemical binding]; other site
342451001813	substrate interface [chemical binding]; other site
342451001814	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
342451001815	MPT binding site; other site
342451001816	trimer interface [polypeptide binding]; other site
342451001817	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
342451001818	trimer interface [polypeptide binding]; other site
342451001819	dimer interface [polypeptide binding]; other site
342451001820	putative active site [active]
342451001821	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
342451001822	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
342451001823	dimer interface [polypeptide binding]; other site
342451001824	putative functional site; other site
342451001825	putative MPT binding site; other site
342451001826	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
342451001827	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
342451001828	MoaE homodimer interface [polypeptide binding]; other site
342451001829	MoaD interaction [polypeptide binding]; other site
342451001830	active site residues [active]
342451001831	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
342451001832	MoaE interaction surface [polypeptide binding]; other site
342451001833	MoeB interaction surface [polypeptide binding]; other site
342451001834	thiocarboxylated glycine; other site
342451001835	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
342451001836	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
342451001837	GTP binding site; other site
342451001838	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
342451001839	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
342451001840	FeS/SAM binding site; other site
342451001841	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
342451001842	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
342451001843	Transcriptional regulators [Transcription]; Region: MarR; COG1846
342451001844	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451001845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001846	putative substrate translocation pore; other site
342451001847	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451001848	MarR family; Region: MarR_2; pfam12802
342451001849	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
342451001850	FemAB family; Region: FemAB; pfam02388
342451001851	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
342451001852	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
342451001853	Protein export membrane protein; Region: SecD_SecF; cl14618
342451001854	Protein export membrane protein; Region: SecD_SecF; cl14618
342451001855	Predicted permeases [General function prediction only]; Region: COG0679
342451001856	glucose-1-dehydrogenase; Provisional; Region: PRK08936
342451001857	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
342451001858	NAD binding site [chemical binding]; other site
342451001859	homodimer interface [polypeptide binding]; other site
342451001860	active site
342451001861	Sugar transport protein; Region: Sugar_transport; pfam06800
342451001862	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
342451001863	DNA topoisomerase III; Provisional; Region: PRK07726
342451001864	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
342451001865	active site
342451001866	putative interdomain interaction site [polypeptide binding]; other site
342451001867	putative metal-binding site [ion binding]; other site
342451001868	putative nucleotide binding site [chemical binding]; other site
342451001869	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
342451001870	domain I; other site
342451001871	DNA binding groove [nucleotide binding]
342451001872	phosphate binding site [ion binding]; other site
342451001873	domain II; other site
342451001874	domain III; other site
342451001875	nucleotide binding site [chemical binding]; other site
342451001876	catalytic site [active]
342451001877	domain IV; other site
342451001878	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
342451001879	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
342451001880	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
342451001881	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
342451001882	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
342451001883	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
342451001884	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
342451001885	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
342451001886	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
342451001887	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
342451001888	putative translocon binding site; other site
342451001889	protein-rRNA interface [nucleotide binding]; other site
342451001890	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
342451001891	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
342451001892	G-X-X-G motif; other site
342451001893	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
342451001894	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
342451001895	23S rRNA interface [nucleotide binding]; other site
342451001896	5S rRNA interface [nucleotide binding]; other site
342451001897	putative antibiotic binding site [chemical binding]; other site
342451001898	L25 interface [polypeptide binding]; other site
342451001899	L27 interface [polypeptide binding]; other site
342451001900	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
342451001901	23S rRNA interface [nucleotide binding]; other site
342451001902	putative translocon interaction site; other site
342451001903	signal recognition particle (SRP54) interaction site; other site
342451001904	L23 interface [polypeptide binding]; other site
342451001905	trigger factor interaction site; other site
342451001906	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
342451001907	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
342451001908	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
342451001909	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
342451001910	RNA binding site [nucleotide binding]; other site
342451001911	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
342451001912	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
342451001913	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
342451001914	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
342451001915	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
342451001916	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
342451001917	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
342451001918	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
342451001919	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
342451001920	5S rRNA interface [nucleotide binding]; other site
342451001921	L27 interface [polypeptide binding]; other site
342451001922	23S rRNA interface [nucleotide binding]; other site
342451001923	L5 interface [polypeptide binding]; other site
342451001924	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
342451001925	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
342451001926	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
342451001927	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
342451001928	23S rRNA binding site [nucleotide binding]; other site
342451001929	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
342451001930	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
342451001931	SecY translocase; Region: SecY; pfam00344
342451001932	adenylate kinase; Reviewed; Region: adk; PRK00279
342451001933	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
342451001934	AMP-binding site [chemical binding]; other site
342451001935	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
342451001936	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
342451001937	rRNA binding site [nucleotide binding]; other site
342451001938	predicted 30S ribosome binding site; other site
342451001939	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
342451001940	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
342451001941	30S ribosomal protein S13; Region: bact_S13; TIGR03631
342451001942	30S ribosomal protein S11; Validated; Region: PRK05309
342451001943	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
342451001944	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
342451001945	alphaNTD homodimer interface [polypeptide binding]; other site
342451001946	alphaNTD - beta interaction site [polypeptide binding]; other site
342451001947	alphaNTD - beta' interaction site [polypeptide binding]; other site
342451001948	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
342451001949	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
342451001950	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
342451001951	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
342451001952	Walker A/P-loop; other site
342451001953	ATP binding site [chemical binding]; other site
342451001954	Q-loop/lid; other site
342451001955	ABC transporter signature motif; other site
342451001956	Walker B; other site
342451001957	D-loop; other site
342451001958	H-loop/switch region; other site
342451001959	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
342451001960	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
342451001961	Walker A/P-loop; other site
342451001962	ATP binding site [chemical binding]; other site
342451001963	Q-loop/lid; other site
342451001964	ABC transporter signature motif; other site
342451001965	Walker B; other site
342451001966	D-loop; other site
342451001967	H-loop/switch region; other site
342451001968	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
342451001969	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
342451001970	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
342451001971	dimerization interface 3.5A [polypeptide binding]; other site
342451001972	active site
342451001973	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
342451001974	23S rRNA interface [nucleotide binding]; other site
342451001975	L3 interface [polypeptide binding]; other site
342451001976	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
342451001977	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
342451001978	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
342451001979	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
342451001980	Prostaglandin dehydrogenases; Region: PGDH; cd05288
342451001981	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
342451001982	NAD(P) binding site [chemical binding]; other site
342451001983	substrate binding site [chemical binding]; other site
342451001984	dimer interface [polypeptide binding]; other site
342451001985	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
342451001986	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
342451001987	putative NAD(P) binding site [chemical binding]; other site
342451001988	dimer interface [polypeptide binding]; other site
342451001989	BCCT family transporter; Region: BCCT; pfam02028
342451001990	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
342451001991	Asp23 family; Region: Asp23; pfam03780
342451001992	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
342451001993	IucA / IucC family; Region: IucA_IucC; pfam04183
342451001994	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
342451001995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451001996	H+ Antiporter protein; Region: 2A0121; TIGR00900
342451001997	putative substrate translocation pore; other site
342451001998	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
342451001999	IucA / IucC family; Region: IucA_IucC; pfam04183
342451002000	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
342451002001	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
342451002002	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
342451002003	dimer interface [polypeptide binding]; other site
342451002004	active site
342451002005	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342451002006	substrate binding site [chemical binding]; other site
342451002007	catalytic residue [active]
342451002008	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
342451002009	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
342451002010	siderophore binding site; other site
342451002011	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
342451002012	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
342451002013	ABC-ATPase subunit  interface; other site
342451002014	dimer interface [polypeptide binding]; other site
342451002015	putative PBP binding regions; other site
342451002016	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
342451002017	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
342451002018	ABC-ATPase subunit  interface; other site
342451002019	dimer interface [polypeptide binding]; other site
342451002020	putative PBP binding regions; other site
342451002021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
342451002022	Nucleoside recognition; Region: Gate; pfam07670
342451002023	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13315
342451002024	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
342451002025	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
342451002026	substrate binding site; other site
342451002027	dimerization interface; other site
342451002028	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
342451002029	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
342451002030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451002031	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451002032	putative substrate translocation pore; other site
342451002033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451002034	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
342451002035	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
342451002036	Walker A motif; other site
342451002037	Arginase family; Region: Arginase; cd09989
342451002038	active site
342451002039	Mn binding site [ion binding]; other site
342451002040	oligomer interface [polypeptide binding]; other site
342451002041	TIGR00159 family protein; Region: TIGR00159
342451002042	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
342451002043	YbbR-like protein; Region: YbbR; pfam07949
342451002044	YbbR-like protein; Region: YbbR; pfam07949
342451002045	YbbR-like protein; Region: YbbR; pfam07949
342451002046	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
342451002047	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
342451002048	active site
342451002049	substrate binding site [chemical binding]; other site
342451002050	metal binding site [ion binding]; metal-binding site
342451002051	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
342451002052	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
342451002053	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
342451002054	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
342451002055	active site
342451002056	phosphorylation site [posttranslational modification]
342451002057	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
342451002058	HTH domain; Region: HTH_11; pfam08279
342451002059	PRD domain; Region: PRD; pfam00874
342451002060	PRD domain; Region: PRD; pfam00874
342451002061	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
342451002062	active site
342451002063	P-loop; other site
342451002064	phosphorylation site [posttranslational modification]
342451002065	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
342451002066	active site
342451002067	phosphorylation site [posttranslational modification]
342451002068	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
342451002069	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
342451002070	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
342451002071	active site
342451002072	P-loop; other site
342451002073	phosphorylation site [posttranslational modification]
342451002074	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
342451002075	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
342451002076	glutaminase active site [active]
342451002077	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
342451002078	dimer interface [polypeptide binding]; other site
342451002079	active site
342451002080	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
342451002081	dimer interface [polypeptide binding]; other site
342451002082	active site
342451002083	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
342451002084	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
342451002085	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451002086	Walker A/P-loop; other site
342451002087	ATP binding site [chemical binding]; other site
342451002088	Q-loop/lid; other site
342451002089	ABC transporter signature motif; other site
342451002090	Walker B; other site
342451002091	D-loop; other site
342451002092	H-loop/switch region; other site
342451002093	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
342451002094	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451002095	active site
342451002096	motif I; other site
342451002097	motif II; other site
342451002098	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451002099	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
342451002100	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
342451002101	active site
342451002102	metal binding site [ion binding]; metal-binding site
342451002103	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
342451002104	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
342451002105	dimerization interface [polypeptide binding]; other site
342451002106	putative DNA binding site [nucleotide binding]; other site
342451002107	putative Zn2+ binding site [ion binding]; other site
342451002108	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
342451002109	NADH(P)-binding; Region: NAD_binding_10; pfam13460
342451002110	NAD(P) binding site [chemical binding]; other site
342451002111	putative active site [active]
342451002112	Transcriptional regulators [Transcription]; Region: FadR; COG2186
342451002113	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342451002114	DNA-binding site [nucleotide binding]; DNA binding site
342451002115	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
342451002116	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
342451002117	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
342451002118	Predicted membrane protein [Function unknown]; Region: COG2855
342451002119	EVE domain; Region: EVE; cl00728
342451002120	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
342451002121	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
342451002122	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
342451002123	substrate binding site [chemical binding]; other site
342451002124	dimer interface [polypeptide binding]; other site
342451002125	ATP binding site [chemical binding]; other site
342451002126	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
342451002127	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
342451002128	dimerization interface [polypeptide binding]; other site
342451002129	DPS ferroxidase diiron center [ion binding]; other site
342451002130	ion pore; other site
342451002131	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
342451002132	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
342451002133	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
342451002134	intersubunit interface [polypeptide binding]; other site
342451002135	active site
342451002136	catalytic residue [active]
342451002137	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
342451002138	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
342451002139	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
342451002140	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
342451002141	phosphopentomutase; Provisional; Region: PRK05362
342451002142	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
342451002143	Predicted membrane protein [Function unknown]; Region: COG4270
342451002144	S-ribosylhomocysteinase; Provisional; Region: PRK02260
342451002145	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
342451002146	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
342451002147	metal binding site [ion binding]; metal-binding site
342451002148	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
342451002149	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
342451002150	pantothenate kinase; Provisional; Region: PRK13317
342451002151	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
342451002152	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
342451002153	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451002154	Coenzyme A binding pocket [chemical binding]; other site
342451002155	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
342451002156	CTP synthetase; Validated; Region: pyrG; PRK05380
342451002157	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
342451002158	Catalytic site [active]
342451002159	active site
342451002160	UTP binding site [chemical binding]; other site
342451002161	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
342451002162	active site
342451002163	putative oxyanion hole; other site
342451002164	catalytic triad [active]
342451002165	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
342451002166	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
342451002167	intersubunit interface [polypeptide binding]; other site
342451002168	active site
342451002169	zinc binding site [ion binding]; other site
342451002170	Na+ binding site [ion binding]; other site
342451002171	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
342451002172	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
342451002173	hinge; other site
342451002174	active site
342451002175	Predicted transcriptional regulators [Transcription]; Region: COG1733
342451002176	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
342451002177	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
342451002178	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
342451002179	NAD binding site [chemical binding]; other site
342451002180	catalytic residues [active]
342451002181	transcription termination factor Rho; Provisional; Region: rho; PRK09376
342451002182	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
342451002183	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
342451002184	RNA binding site [nucleotide binding]; other site
342451002185	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
342451002186	multimer interface [polypeptide binding]; other site
342451002187	Walker A motif; other site
342451002188	ATP binding site [chemical binding]; other site
342451002189	Walker B motif; other site
342451002190	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
342451002191	thymidine kinase; Provisional; Region: PRK04296
342451002192	peptide chain release factor 1; Validated; Region: prfA; PRK00591
342451002193	This domain is found in peptide chain release factors; Region: PCRF; smart00937
342451002194	RF-1 domain; Region: RF-1; pfam00472
342451002195	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
342451002196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451002197	S-adenosylmethionine binding site [chemical binding]; other site
342451002198	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
342451002199	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
342451002200	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
342451002201	Low molecular weight phosphatase family; Region: LMWPc; cd00115
342451002202	active site
342451002203	hypothetical protein; Provisional; Region: PRK13690
342451002204	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
342451002205	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
342451002206	dimer interface [polypeptide binding]; other site
342451002207	active site
342451002208	glycine-pyridoxal phosphate binding site [chemical binding]; other site
342451002209	folate binding site [chemical binding]; other site
342451002210	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451002211	active site
342451002212	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
342451002213	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
342451002214	active site
342451002215	homodimer interface [polypeptide binding]; other site
342451002216	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
342451002217	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
342451002218	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
342451002219	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
342451002220	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
342451002221	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
342451002222	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
342451002223	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
342451002224	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
342451002225	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
342451002226	beta subunit interaction interface [polypeptide binding]; other site
342451002227	Walker A motif; other site
342451002228	ATP binding site [chemical binding]; other site
342451002229	Walker B motif; other site
342451002230	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
342451002231	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
342451002232	core domain interface [polypeptide binding]; other site
342451002233	delta subunit interface [polypeptide binding]; other site
342451002234	epsilon subunit interface [polypeptide binding]; other site
342451002235	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
342451002236	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
342451002237	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
342451002238	alpha subunit interaction interface [polypeptide binding]; other site
342451002239	Walker A motif; other site
342451002240	ATP binding site [chemical binding]; other site
342451002241	Walker B motif; other site
342451002242	inhibitor binding site; inhibition site
342451002243	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
342451002244	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
342451002245	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
342451002246	gamma subunit interface [polypeptide binding]; other site
342451002247	epsilon subunit interface [polypeptide binding]; other site
342451002248	LBP interface [polypeptide binding]; other site
342451002249	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
342451002250	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
342451002251	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
342451002252	hinge; other site
342451002253	active site
342451002254	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
342451002255	YwpF-like protein; Region: YwpF; pfam14183
342451002256	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
342451002257	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
342451002258	dimer interface [polypeptide binding]; other site
342451002259	ssDNA binding site [nucleotide binding]; other site
342451002260	tetramer (dimer of dimers) interface [polypeptide binding]; other site
342451002261	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
342451002262	N-acetyl-D-glucosamine binding site [chemical binding]; other site
342451002263	catalytic residue [active]
342451002264	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
342451002265	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
342451002266	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
342451002267	dimer interface [polypeptide binding]; other site
342451002268	substrate binding site [chemical binding]; other site
342451002269	ATP binding site [chemical binding]; other site
342451002270	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
342451002271	substrate binding site [chemical binding]; other site
342451002272	multimerization interface [polypeptide binding]; other site
342451002273	ATP binding site [chemical binding]; other site
342451002274	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
342451002275	thiamine phosphate binding site [chemical binding]; other site
342451002276	active site
342451002277	pyrophosphate binding site [ion binding]; other site
342451002278	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
342451002279	OxaA-like protein precursor; Provisional; Region: PRK02463
342451002280	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
342451002281	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
342451002282	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
342451002283	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
342451002284	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
342451002285	putative active site [active]
342451002286	catalytic site [active]
342451002287	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
342451002288	putative active site [active]
342451002289	catalytic site [active]
342451002290	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
342451002291	putative homodimer interface [polypeptide binding]; other site
342451002292	putative homotetramer interface [polypeptide binding]; other site
342451002293	allosteric switch controlling residues; other site
342451002294	putative metal binding site [ion binding]; other site
342451002295	putative homodimer-homodimer interface [polypeptide binding]; other site
342451002296	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
342451002297	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
342451002298	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
342451002299	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
342451002300	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
342451002301	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
342451002302	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
342451002303	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342451002304	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
342451002305	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
342451002306	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
342451002307	ATP binding site [chemical binding]; other site
342451002308	Mg++ binding site [ion binding]; other site
342451002309	motif III; other site
342451002310	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342451002311	nucleotide binding region [chemical binding]; other site
342451002312	ATP-binding site [chemical binding]; other site
342451002313	Bacterial PH domain; Region: DUF304; pfam03703
342451002314	Predicted membrane protein [Function unknown]; Region: COG3428
342451002315	Bacterial PH domain; Region: DUF304; pfam03703
342451002316	Bacterial PH domain; Region: DUF304; pfam03703
342451002317	Uncharacterized conserved protein [Function unknown]; Region: COG3402
342451002318	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
342451002319	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
342451002320	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
342451002321	active site
342451002322	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342451002323	dimer interface [polypeptide binding]; other site
342451002324	substrate binding site [chemical binding]; other site
342451002325	catalytic residues [active]
342451002326	PemK-like protein; Region: PemK; pfam02452
342451002327	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
342451002328	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
342451002329	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
342451002330	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
342451002331	anti sigma factor interaction site; other site
342451002332	regulatory phosphorylation site [posttranslational modification]; other site
342451002333	serine-protein kinase RsbW; Provisional; Region: PRK04069
342451002334	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
342451002335	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342451002336	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342451002337	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
342451002338	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
342451002339	DNA binding residues [nucleotide binding]
342451002340	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
342451002341	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
342451002342	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
342451002343	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
342451002344	aromatic arch; other site
342451002345	DCoH dimer interaction site [polypeptide binding]; other site
342451002346	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
342451002347	DCoH tetramer interaction site [polypeptide binding]; other site
342451002348	substrate binding site [chemical binding]; other site
342451002349	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
342451002350	RNA binding site [nucleotide binding]; other site
342451002351	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
342451002352	hypothetical protein; Provisional; Region: PRK04351
342451002353	threonine dehydratase; Validated; Region: PRK08639
342451002354	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
342451002355	tetramer interface [polypeptide binding]; other site
342451002356	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451002357	catalytic residue [active]
342451002358	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
342451002359	putative Ile/Val binding site [chemical binding]; other site
342451002360	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
342451002361	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
342451002362	substrate binding site [chemical binding]; other site
342451002363	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
342451002364	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
342451002365	substrate binding site [chemical binding]; other site
342451002366	ligand binding site [chemical binding]; other site
342451002367	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
342451002368	tartrate dehydrogenase; Region: TTC; TIGR02089
342451002369	2-isopropylmalate synthase; Validated; Region: PRK00915
342451002370	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
342451002371	active site
342451002372	catalytic residues [active]
342451002373	metal binding site [ion binding]; metal-binding site
342451002374	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
342451002375	ketol-acid reductoisomerase; Provisional; Region: PRK05479
342451002376	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
342451002377	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
342451002378	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
342451002379	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
342451002380	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
342451002381	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
342451002382	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
342451002383	PYR/PP interface [polypeptide binding]; other site
342451002384	dimer interface [polypeptide binding]; other site
342451002385	TPP binding site [chemical binding]; other site
342451002386	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
342451002387	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
342451002388	TPP-binding site [chemical binding]; other site
342451002389	dimer interface [polypeptide binding]; other site
342451002390	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
342451002391	6-phosphogluconate dehydratase; Region: edd; TIGR01196
342451002392	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
342451002393	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
342451002394	Glycoprotease family; Region: Peptidase_M22; pfam00814
342451002395	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
342451002396	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451002397	Coenzyme A binding pocket [chemical binding]; other site
342451002398	UGMP family protein; Validated; Region: PRK09604
342451002399	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
342451002400	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
342451002401	dimer interface [polypeptide binding]; other site
342451002402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451002403	Walker A/P-loop; other site
342451002404	ATP binding site [chemical binding]; other site
342451002405	Q-loop/lid; other site
342451002406	ABC transporter signature motif; other site
342451002407	Walker B; other site
342451002408	D-loop; other site
342451002409	H-loop/switch region; other site
342451002410	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
342451002411	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
342451002412	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
342451002413	ABC transporter; Region: ABC_tran_2; pfam12848
342451002414	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
342451002415	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
342451002416	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
342451002417	CoA binding domain; Region: CoA_binding; pfam02629
342451002418	Predicted transporter component [General function prediction only]; Region: COG2391
342451002419	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
342451002420	Sulphur transport; Region: Sulf_transp; pfam04143
342451002421	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
342451002422	CPxP  motif; other site
342451002423	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342451002424	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342451002425	DNA binding site [nucleotide binding]
342451002426	domain linker motif; other site
342451002427	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
342451002428	dimerization interface [polypeptide binding]; other site
342451002429	ligand binding site [chemical binding]; other site
342451002430	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
342451002431	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
342451002432	substrate binding [chemical binding]; other site
342451002433	active site
342451002434	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
342451002435	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
342451002436	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
342451002437	putative substrate binding site [chemical binding]; other site
342451002438	putative ATP binding site [chemical binding]; other site
342451002439	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
342451002440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451002441	active site
342451002442	phosphorylation site [posttranslational modification]
342451002443	intermolecular recognition site; other site
342451002444	dimerization interface [polypeptide binding]; other site
342451002445	LytTr DNA-binding domain; Region: LytTR; pfam04397
342451002446	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
342451002447	Staphylococcal AgrD protein; Region: AgrD; smart00794
342451002448	Accessory gene regulator B; Region: AgrB; smart00793
342451002449	Predicted amidohydrolase [General function prediction only]; Region: COG0388
342451002450	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
342451002451	putative active site [active]
342451002452	catalytic triad [active]
342451002453	putative dimer interface [polypeptide binding]; other site
342451002454	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
342451002455	dimer interface [polypeptide binding]; other site
342451002456	FMN binding site [chemical binding]; other site
342451002457	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
342451002458	CAAX protease self-immunity; Region: Abi; pfam02517
342451002459	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
342451002460	oligomerisation interface [polypeptide binding]; other site
342451002461	mobile loop; other site
342451002462	roof hairpin; other site
342451002463	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
342451002464	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
342451002465	ring oligomerisation interface [polypeptide binding]; other site
342451002466	ATP/Mg binding site [chemical binding]; other site
342451002467	stacking interactions; other site
342451002468	hinge regions; other site
342451002469	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451002470	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
342451002471	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451002472	Coenzyme A binding pocket [chemical binding]; other site
342451002473	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342451002474	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
342451002475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451002476	homodimer interface [polypeptide binding]; other site
342451002477	catalytic residue [active]
342451002478	Predicted transcriptional regulators [Transcription]; Region: COG1725
342451002479	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342451002480	DNA-binding site [nucleotide binding]; DNA binding site
342451002481	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
342451002482	Walker A/P-loop; other site
342451002483	ATP binding site [chemical binding]; other site
342451002484	ABC transporter; Region: ABC_tran; pfam00005
342451002485	Q-loop/lid; other site
342451002486	ABC transporter signature motif; other site
342451002487	Walker B; other site
342451002488	D-loop; other site
342451002489	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
342451002490	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
342451002491	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
342451002492	Walker A/P-loop; other site
342451002493	ATP binding site [chemical binding]; other site
342451002494	Q-loop/lid; other site
342451002495	ABC transporter signature motif; other site
342451002496	Walker B; other site
342451002497	D-loop; other site
342451002498	H-loop/switch region; other site
342451002499	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
342451002500	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
342451002501	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
342451002502	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
342451002503	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
342451002504	active site
342451002505	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
342451002506	YolD-like protein; Region: YolD; pfam08863
342451002507	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
342451002508	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
342451002509	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
342451002510	NAD(P) binding site [chemical binding]; other site
342451002511	catalytic residues [active]
342451002512	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
342451002513	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
342451002514	DHHA2 domain; Region: DHHA2; pfam02833
342451002515	Isochorismatase family; Region: Isochorismatase; pfam00857
342451002516	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
342451002517	catalytic triad [active]
342451002518	conserved cis-peptide bond; other site
342451002519	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
342451002520	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
342451002521	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
342451002522	transmembrane helices; other site
342451002523	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
342451002524	Prephenate dehydratase; Region: PDT; pfam00800
342451002525	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
342451002526	putative L-Phe binding site [chemical binding]; other site
342451002527	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
342451002528	active site
342451002529	dimer interface [polypeptide binding]; other site
342451002530	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
342451002531	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
342451002532	active site
342451002533	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
342451002534	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
342451002535	homodimer interface [polypeptide binding]; other site
342451002536	NAD binding pocket [chemical binding]; other site
342451002537	ATP binding pocket [chemical binding]; other site
342451002538	Mg binding site [ion binding]; other site
342451002539	active-site loop [active]
342451002540	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
342451002541	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
342451002542	NETI protein; Region: NETI; pfam14044
342451002543	adenylosuccinate lyase; Provisional; Region: PRK07492
342451002544	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
342451002545	tetramer interface [polypeptide binding]; other site
342451002546	active site
342451002547	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
342451002548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
342451002549	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
342451002550	PcrB family; Region: PcrB; pfam01884
342451002551	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
342451002552	substrate binding site [chemical binding]; other site
342451002553	putative active site [active]
342451002554	dimer interface [polypeptide binding]; other site
342451002555	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
342451002556	Part of AAA domain; Region: AAA_19; pfam13245
342451002557	Family description; Region: UvrD_C_2; pfam13538
342451002558	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
342451002559	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
342451002560	nucleotide binding pocket [chemical binding]; other site
342451002561	K-X-D-G motif; other site
342451002562	catalytic site [active]
342451002563	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
342451002564	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
342451002565	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
342451002566	Dimer interface [polypeptide binding]; other site
342451002567	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
342451002568	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
342451002569	putative dimer interface [polypeptide binding]; other site
342451002570	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
342451002571	putative dimer interface [polypeptide binding]; other site
342451002572	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
342451002573	Na binding site [ion binding]; other site
342451002574	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
342451002575	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
342451002576	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
342451002577	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
342451002578	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
342451002579	GatB domain; Region: GatB_Yqey; pfam02637
342451002580	putative lipid kinase; Reviewed; Region: PRK13337
342451002581	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
342451002582	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
342451002583	TRAM domain; Region: TRAM; cl01282
342451002584	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
342451002585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451002586	S-adenosylmethionine binding site [chemical binding]; other site
342451002587	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
342451002588	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
342451002589	active site
342451002590	DNA polymerase IV; Validated; Region: PRK02406
342451002591	DNA binding site [nucleotide binding]
342451002592	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
342451002593	active site
342451002594	catalytic site [active]
342451002595	substrate binding site [chemical binding]; other site
342451002596	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
342451002597	Ferritin-like domain; Region: Ferritin; pfam00210
342451002598	ferroxidase diiron center [ion binding]; other site
342451002599	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
342451002600	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342451002601	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
342451002602	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
342451002603	catalytic triad [active]
342451002604	Homeodomain-like domain; Region: HTH_23; cl17451
342451002605	Integrase core domain; Region: rve; pfam00665
342451002606	Integrase core domain; Region: rve_2; pfam13333
342451002607	Predicted membrane protein [Function unknown]; Region: COG4129
342451002608	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
342451002609	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
342451002610	active site
342451002611	Predicted membrane protein [Function unknown]; Region: COG4758
342451002612	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
342451002613	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
342451002614	Histidine kinase; Region: HisKA_3; pfam07730
342451002615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451002616	ATP binding site [chemical binding]; other site
342451002617	Mg2+ binding site [ion binding]; other site
342451002618	G-X-G motif; other site
342451002619	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
342451002620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451002621	active site
342451002622	phosphorylation site [posttranslational modification]
342451002623	intermolecular recognition site; other site
342451002624	dimerization interface [polypeptide binding]; other site
342451002625	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
342451002626	DNA binding residues [nucleotide binding]
342451002627	dimerization interface [polypeptide binding]; other site
342451002628	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
342451002629	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
342451002630	Low molecular weight phosphatase family; Region: LMWPc; cd00115
342451002631	active site
342451002632	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
342451002633	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
342451002634	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
342451002635	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
342451002636	Radical SAM superfamily; Region: Radical_SAM; pfam04055
342451002637	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
342451002638	FeS/SAM binding site; other site
342451002639	YfkB-like domain; Region: YfkB; pfam08756
342451002640	intracellular protease, PfpI family; Region: PfpI; TIGR01382
342451002641	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
342451002642	proposed catalytic triad [active]
342451002643	conserved cys residue [active]
342451002644	glycosyltransferase; Provisional; Region: PRK13481
342451002645	Transglycosylase; Region: Transgly; pfam00912
342451002646	recombination regulator RecX; Provisional; Region: recX; PRK14135
342451002647	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
342451002648	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
342451002649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451002650	Walker A/P-loop; other site
342451002651	ATP binding site [chemical binding]; other site
342451002652	Q-loop/lid; other site
342451002653	ABC transporter signature motif; other site
342451002654	Walker B; other site
342451002655	D-loop; other site
342451002656	H-loop/switch region; other site
342451002657	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
342451002658	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
342451002659	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
342451002660	minor groove reading motif; other site
342451002661	helix-hairpin-helix signature motif; other site
342451002662	substrate binding pocket [chemical binding]; other site
342451002663	active site
342451002664	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
342451002665	DNA binding and oxoG recognition site [nucleotide binding]
342451002666	hypothetical protein; Provisional; Region: PRK13662
342451002667	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
342451002668	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
342451002669	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
342451002670	Walker A/P-loop; other site
342451002671	ATP binding site [chemical binding]; other site
342451002672	Q-loop/lid; other site
342451002673	ABC transporter signature motif; other site
342451002674	Walker B; other site
342451002675	D-loop; other site
342451002676	H-loop/switch region; other site
342451002677	Predicted membrane protein [Function unknown]; Region: COG4129
342451002678	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
342451002679	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
342451002680	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
342451002681	inhibitor-cofactor binding pocket; inhibition site
342451002682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451002683	catalytic residue [active]
342451002684	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
342451002685	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
342451002686	catalytic triad [active]
342451002687	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
342451002688	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
342451002689	putative ligand binding site [chemical binding]; other site
342451002690	NAD binding site [chemical binding]; other site
342451002691	catalytic site [active]
342451002692	ferric uptake regulator; Provisional; Region: fur; PRK09462
342451002693	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
342451002694	metal binding site 2 [ion binding]; metal-binding site
342451002695	putative DNA binding helix; other site
342451002696	metal binding site 1 [ion binding]; metal-binding site
342451002697	dimer interface [polypeptide binding]; other site
342451002698	structural Zn2+ binding site [ion binding]; other site
342451002699	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
342451002700	tetramerization interface [polypeptide binding]; other site
342451002701	active site
342451002702	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540
342451002703	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
342451002704	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
342451002705	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
342451002706	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
342451002707	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
342451002708	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
342451002709	substrate binding pocket [chemical binding]; other site
342451002710	membrane-bound complex binding site; other site
342451002711	hinge residues; other site
342451002712	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
342451002713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451002714	dimer interface [polypeptide binding]; other site
342451002715	conserved gate region; other site
342451002716	ABC-ATPase subunit interface; other site
342451002717	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
342451002718	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
342451002719	Walker A/P-loop; other site
342451002720	ATP binding site [chemical binding]; other site
342451002721	Q-loop/lid; other site
342451002722	ABC transporter signature motif; other site
342451002723	Walker B; other site
342451002724	D-loop; other site
342451002725	H-loop/switch region; other site
342451002726	epoxyqueuosine reductase; Region: TIGR00276
342451002727	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
342451002728	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
342451002729	HEAT repeats; Region: HEAT_2; pfam13646
342451002730	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
342451002731	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
342451002732	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
342451002733	active site
342451002734	fumarate hydratase; Reviewed; Region: fumC; PRK00485
342451002735	Class II fumarases; Region: Fumarase_classII; cd01362
342451002736	active site
342451002737	tetramer interface [polypeptide binding]; other site
342451002738	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
342451002739	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
342451002740	active site
342451002741	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
342451002742	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
342451002743	Histidine kinase; Region: HisKA_3; pfam07730
342451002744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451002745	ATP binding site [chemical binding]; other site
342451002746	Mg2+ binding site [ion binding]; other site
342451002747	G-X-G motif; other site
342451002748	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
342451002749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451002750	active site
342451002751	phosphorylation site [posttranslational modification]
342451002752	intermolecular recognition site; other site
342451002753	dimerization interface [polypeptide binding]; other site
342451002754	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
342451002755	DNA binding residues [nucleotide binding]
342451002756	dimerization interface [polypeptide binding]; other site
342451002757	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
342451002758	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
342451002759	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
342451002760	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
342451002761	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
342451002762	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
342451002763	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
342451002764	putative active site [active]
342451002765	putative substrate binding site [chemical binding]; other site
342451002766	putative cosubstrate binding site; other site
342451002767	catalytic site [active]
342451002768	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
342451002769	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451002770	non-specific DNA binding site [nucleotide binding]; other site
342451002771	salt bridge; other site
342451002772	sequence-specific DNA binding site [nucleotide binding]; other site
342451002773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
342451002774	hypothetical protein; Provisional; Region: PRK13676
342451002775	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
342451002776	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
342451002777	active site
342451002778	metal binding site [ion binding]; metal-binding site
342451002779	DNA binding site [nucleotide binding]
342451002780	Uncharacterized conserved protein [Function unknown]; Region: COG4717
342451002781	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451002782	Walker A/P-loop; other site
342451002783	ATP binding site [chemical binding]; other site
342451002784	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
342451002785	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
342451002786	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
342451002787	generic binding surface II; other site
342451002788	generic binding surface I; other site
342451002789	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
342451002790	Zn2+ binding site [ion binding]; other site
342451002791	Mg2+ binding site [ion binding]; other site
342451002792	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
342451002793	Integral membrane protein DUF106; Region: DUF106; pfam01956
342451002794	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
342451002795	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
342451002796	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
342451002797	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
342451002798	HIT family signature motif; other site
342451002799	catalytic residue [active]
342451002800	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
342451002801	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
342451002802	Walker A/P-loop; other site
342451002803	ATP binding site [chemical binding]; other site
342451002804	Q-loop/lid; other site
342451002805	ABC transporter signature motif; other site
342451002806	Walker B; other site
342451002807	D-loop; other site
342451002808	H-loop/switch region; other site
342451002809	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
342451002810	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
342451002811	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
342451002812	substrate binding site [chemical binding]; other site
342451002813	active site
342451002814	ferrochelatase; Provisional; Region: PRK12435
342451002815	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
342451002816	C-terminal domain interface [polypeptide binding]; other site
342451002817	active site
342451002818	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
342451002819	active site
342451002820	N-terminal domain interface [polypeptide binding]; other site
342451002821	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
342451002822	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
342451002823	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
342451002824	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
342451002825	Uncharacterized conserved protein [Function unknown]; Region: COG2128
342451002826	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
342451002827	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
342451002828	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
342451002829	acyl-activating enzyme (AAE) consensus motif; other site
342451002830	putative AMP binding site [chemical binding]; other site
342451002831	putative active site [active]
342451002832	putative CoA binding site [chemical binding]; other site
342451002833	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
342451002834	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
342451002835	metal binding site [ion binding]; metal-binding site
342451002836	substrate binding pocket [chemical binding]; other site
342451002837	Haemolytic domain; Region: Haemolytic; pfam01809
342451002838	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
342451002839	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
342451002840	nudix motif; other site
342451002841	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
342451002842	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
342451002843	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
342451002844	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
342451002845	active site
342451002846	substrate-binding site [chemical binding]; other site
342451002847	metal-binding site [ion binding]
342451002848	ATP binding site [chemical binding]; other site
342451002849	S-adenosylmethionine synthetase; Validated; Region: PRK05250
342451002850	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
342451002851	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
342451002852	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
342451002853	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
342451002854	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342451002855	active site
342451002856	catalytic tetrad [active]
342451002857	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
342451002858	camphor resistance protein CrcB; Provisional; Region: PRK14201
342451002859	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
342451002860	active site
342451002861	intersubunit interactions; other site
342451002862	catalytic residue [active]
342451002863	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
342451002864	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
342451002865	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
342451002866	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342451002867	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
342451002868	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
342451002869	HTH-like domain; Region: HTH_21; pfam13276
342451002870	Integrase core domain; Region: rve; pfam00665
342451002871	Integrase core domain; Region: rve_2; pfam13333
342451002872	Transposase; Region: HTH_Tnp_1; pfam01527
342451002873	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
342451002874	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
342451002875	Helix-turn-helix domain; Region: HTH_28; pfam13518
342451002876	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
342451002877	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
342451002878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
342451002879	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
342451002880	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
342451002881	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
342451002882	catalytic motif [active]
342451002883	Zn binding site [ion binding]; other site
342451002884	RibD C-terminal domain; Region: RibD_C; cl17279
342451002885	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
342451002886	Lumazine binding domain; Region: Lum_binding; pfam00677
342451002887	Lumazine binding domain; Region: Lum_binding; pfam00677
342451002888	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
342451002889	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
342451002890	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
342451002891	dimerization interface [polypeptide binding]; other site
342451002892	active site
342451002893	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
342451002894	homopentamer interface [polypeptide binding]; other site
342451002895	active site
342451002896	Proline dehydrogenase; Region: Pro_dh; cl03282
342451002897	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
342451002898	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
342451002899	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
342451002900	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
342451002901	tetramer (dimer of dimers) interface [polypeptide binding]; other site
342451002902	NAD binding site [chemical binding]; other site
342451002903	dimer interface [polypeptide binding]; other site
342451002904	substrate binding site [chemical binding]; other site
342451002905	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
342451002906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451002907	S-adenosylmethionine binding site [chemical binding]; other site
342451002908	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
342451002909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451002910	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451002911	putative substrate translocation pore; other site
342451002912	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
342451002913	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
342451002914	HIGH motif; other site
342451002915	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
342451002916	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
342451002917	active site
342451002918	KMSKS motif; other site
342451002919	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
342451002920	tRNA binding surface [nucleotide binding]; other site
342451002921	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
342451002922	active site residue [active]
342451002923	HI0933-like protein; Region: HI0933_like; pfam03486
342451002924	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
342451002925	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
342451002926	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
342451002927	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
342451002928	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342451002929	RNA binding surface [nucleotide binding]; other site
342451002930	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
342451002931	active site
342451002932	uracil binding [chemical binding]; other site
342451002933	YtxH-like protein; Region: YtxH; pfam12732
342451002934	dipeptidase PepV; Reviewed; Region: PRK07318
342451002935	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
342451002936	active site
342451002937	metal binding site [ion binding]; metal-binding site
342451002938	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
342451002939	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
342451002940	homodimer interface [polypeptide binding]; other site
342451002941	substrate-cofactor binding pocket; other site
342451002942	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451002943	catalytic residue [active]
342451002944	Phosphotransferase enzyme family; Region: APH; pfam01636
342451002945	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
342451002946	active site
342451002947	substrate binding site [chemical binding]; other site
342451002948	ATP binding site [chemical binding]; other site
342451002949	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
342451002950	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
342451002951	Predicted small secreted protein [Function unknown]; Region: COG5584
342451002952	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
342451002953	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
342451002954	oligomer interface [polypeptide binding]; other site
342451002955	active site
342451002956	metal binding site [ion binding]; metal-binding site
342451002957	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
342451002958	catalytic residues [active]
342451002959	hypothetical protein; Provisional; Region: PRK13668
342451002960	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
342451002961	putative tRNA-binding site [nucleotide binding]; other site
342451002962	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
342451002963	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
342451002964	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
342451002965	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
342451002966	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
342451002967	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342451002968	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
342451002969	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
342451002970	YtxH-like protein; Region: YtxH; pfam12732
342451002971	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
342451002972	Chorismate mutase type II; Region: CM_2; cl00693
342451002973	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
342451002974	catabolite control protein A; Region: ccpA; TIGR01481
342451002975	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342451002976	DNA binding site [nucleotide binding]
342451002977	domain linker motif; other site
342451002978	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
342451002979	dimerization interface [polypeptide binding]; other site
342451002980	effector binding site; other site
342451002981	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
342451002982	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
342451002983	active site
342451002984	Zn binding site [ion binding]; other site
342451002985	acetyl-CoA synthetase; Provisional; Region: PRK04319
342451002986	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
342451002987	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
342451002988	active site
342451002989	acyl-activating enzyme (AAE) consensus motif; other site
342451002990	putative CoA binding site [chemical binding]; other site
342451002991	AMP binding site [chemical binding]; other site
342451002992	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
342451002993	Potassium binding sites [ion binding]; other site
342451002994	Cesium cation binding sites [ion binding]; other site
342451002995	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
342451002996	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
342451002997	Transglycosylase; Region: Transgly; pfam00912
342451002998	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
342451002999	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
342451003000	active site
342451003001	HIGH motif; other site
342451003002	dimer interface [polypeptide binding]; other site
342451003003	KMSKS motif; other site
342451003004	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342451003005	RNA binding surface [nucleotide binding]; other site
342451003006	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
342451003007	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
342451003008	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
342451003009	protein binding site [polypeptide binding]; other site
342451003010	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
342451003011	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
342451003012	putative acyl-acceptor binding pocket; other site
342451003013	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
342451003014	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
342451003015	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
342451003016	active site turn [active]
342451003017	phosphorylation site [posttranslational modification]
342451003018	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
342451003019	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451003020	motif II; other site
342451003021	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
342451003022	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
342451003023	ligand binding site [chemical binding]; other site
342451003024	NAD binding site [chemical binding]; other site
342451003025	dimerization interface [polypeptide binding]; other site
342451003026	catalytic site [active]
342451003027	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
342451003028	putative L-serine binding site [chemical binding]; other site
342451003029	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
342451003030	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342451003031	catalytic residue [active]
342451003032	peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563
342451003033	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
342451003034	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
342451003035	active site
342451003036	catalytic site [active]
342451003037	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
342451003038	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451003039	Coenzyme A binding pocket [chemical binding]; other site
342451003040	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
342451003041	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
342451003042	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342451003043	RNA binding surface [nucleotide binding]; other site
342451003044	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
342451003045	GAF domain; Region: GAF_2; pfam13185
342451003046	septation ring formation regulator EzrA; Provisional; Region: PRK04778
342451003047	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
342451003048	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
342451003049	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342451003050	catalytic residue [active]
342451003051	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
342451003052	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
342451003053	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
342451003054	Ligand Binding Site [chemical binding]; other site
342451003055	hypothetical protein; Provisional; Region: PRK10621
342451003056	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
342451003057	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
342451003058	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
342451003059	oligomer interface [polypeptide binding]; other site
342451003060	tandem repeat interface [polypeptide binding]; other site
342451003061	active site residues [active]
342451003062	RDD family; Region: RDD; pfam06271
342451003063	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
342451003064	dimer interface [polypeptide binding]; other site
342451003065	catalytic triad [active]
342451003066	peroxidatic and resolving cysteines [active]
342451003067	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
342451003068	Methyltransferase domain; Region: Methyltransf_26; pfam13659
342451003069	S-adenosylmethionine binding site [chemical binding]; other site
342451003070	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
342451003071	propionate/acetate kinase; Provisional; Region: PRK12379
342451003072	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
342451003073	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
342451003074	Ligand Binding Site [chemical binding]; other site
342451003075	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
342451003076	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
342451003077	hexamer interface [polypeptide binding]; other site
342451003078	ligand binding site [chemical binding]; other site
342451003079	putative active site [active]
342451003080	NAD(P) binding site [chemical binding]; other site
342451003081	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
342451003082	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
342451003083	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
342451003084	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
342451003085	active site
342451003086	metal-dependent hydrolase; Provisional; Region: PRK00685
342451003087	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
342451003088	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
342451003089	Ligand Binding Site [chemical binding]; other site
342451003090	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
342451003091	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
342451003092	DNA-binding site [nucleotide binding]; DNA binding site
342451003093	DRTGG domain; Region: DRTGG; pfam07085
342451003094	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
342451003095	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
342451003096	DHH family; Region: DHH; pfam01368
342451003097	DHHA1 domain; Region: DHHA1; pfam02272
342451003098	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
342451003099	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
342451003100	active site
342451003101	PHP Thumb interface [polypeptide binding]; other site
342451003102	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
342451003103	generic binding surface I; other site
342451003104	generic binding surface II; other site
342451003105	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
342451003106	Malic enzyme, N-terminal domain; Region: malic; pfam00390
342451003107	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
342451003108	putative NAD(P) binding site [chemical binding]; other site
342451003109	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
342451003110	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
342451003111	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
342451003112	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
342451003113	6-phosphofructokinase; Provisional; Region: PRK03202
342451003114	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
342451003115	dimerization interface [polypeptide binding]; other site
342451003116	allosteric effector site; other site
342451003117	active site
342451003118	ADP/pyrophosphate binding site [chemical binding]; other site
342451003119	fructose-1,6-bisphosphate binding site; other site
342451003120	pyruvate kinase; Provisional; Region: PRK06354
342451003121	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
342451003122	domain interfaces; other site
342451003123	active site
342451003124	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
342451003125	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
342451003126	citrate synthase; Provisional; Region: PRK14035
342451003127	Citrate synthase; Region: Citrate_synt; pfam00285
342451003128	oxalacetate binding site [chemical binding]; other site
342451003129	citrylCoA binding site [chemical binding]; other site
342451003130	coenzyme A binding site [chemical binding]; other site
342451003131	catalytic triad [active]
342451003132	isocitrate dehydrogenase; Reviewed; Region: PRK07006
342451003133	isocitrate dehydrogenase; Validated; Region: PRK07362
342451003134	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342451003135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451003136	active site
342451003137	phosphorylation site [posttranslational modification]
342451003138	intermolecular recognition site; other site
342451003139	dimerization interface [polypeptide binding]; other site
342451003140	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
342451003141	DNA binding site [nucleotide binding]
342451003142	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
342451003143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
342451003144	dimer interface [polypeptide binding]; other site
342451003145	phosphorylation site [posttranslational modification]
342451003146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451003147	ATP binding site [chemical binding]; other site
342451003148	Mg2+ binding site [ion binding]; other site
342451003149	G-X-G motif; other site
342451003150	DNA polymerase I; Provisional; Region: PRK05755
342451003151	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
342451003152	active site
342451003153	metal binding site 1 [ion binding]; metal-binding site
342451003154	putative 5' ssDNA interaction site; other site
342451003155	metal binding site 3; metal-binding site
342451003156	metal binding site 2 [ion binding]; metal-binding site
342451003157	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
342451003158	putative DNA binding site [nucleotide binding]; other site
342451003159	putative metal binding site [ion binding]; other site
342451003160	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
342451003161	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
342451003162	active site
342451003163	DNA binding site [nucleotide binding]
342451003164	catalytic site [active]
342451003165	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
342451003166	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
342451003167	DNA binding site [nucleotide binding]
342451003168	catalytic residue [active]
342451003169	H2TH interface [polypeptide binding]; other site
342451003170	putative catalytic residues [active]
342451003171	turnover-facilitating residue; other site
342451003172	intercalation triad [nucleotide binding]; other site
342451003173	8OG recognition residue [nucleotide binding]; other site
342451003174	putative reading head residues; other site
342451003175	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
342451003176	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
342451003177	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
342451003178	dephospho-CoA kinase; Region: TIGR00152
342451003179	CoA-binding site [chemical binding]; other site
342451003180	ATP-binding [chemical binding]; other site
342451003181	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
342451003182	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
342451003183	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
342451003184	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
342451003185	ATP cone domain; Region: ATP-cone; pfam03477
342451003186	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
342451003187	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
342451003188	primosomal protein DnaI; Reviewed; Region: PRK08939
342451003189	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
342451003190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451003191	Walker A motif; other site
342451003192	ATP binding site [chemical binding]; other site
342451003193	Walker B motif; other site
342451003194	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
342451003195	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
342451003196	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
342451003197	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
342451003198	active site
342451003199	dimer interface [polypeptide binding]; other site
342451003200	motif 1; other site
342451003201	motif 2; other site
342451003202	motif 3; other site
342451003203	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
342451003204	anticodon binding site; other site
342451003205	Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833
342451003206	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
342451003207	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
342451003208	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
342451003209	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
342451003210	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
342451003211	23S rRNA binding site [nucleotide binding]; other site
342451003212	L21 binding site [polypeptide binding]; other site
342451003213	L13 binding site [polypeptide binding]; other site
342451003214	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
342451003215	trigger factor; Provisional; Region: tig; PRK01490
342451003216	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
342451003217	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
342451003218	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
342451003219	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
342451003220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451003221	Walker A motif; other site
342451003222	ATP binding site [chemical binding]; other site
342451003223	Walker B motif; other site
342451003224	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
342451003225	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
342451003226	G1 box; other site
342451003227	GTP/Mg2+ binding site [chemical binding]; other site
342451003228	Switch I region; other site
342451003229	G2 box; other site
342451003230	G3 box; other site
342451003231	Switch II region; other site
342451003232	G4 box; other site
342451003233	G5 box; other site
342451003234	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
342451003235	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
342451003236	tRNA; other site
342451003237	putative tRNA binding site [nucleotide binding]; other site
342451003238	putative NADP binding site [chemical binding]; other site
342451003239	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
342451003240	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
342451003241	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
342451003242	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
342451003243	domain interfaces; other site
342451003244	active site
342451003245	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
342451003246	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
342451003247	active site
342451003248	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
342451003249	dimer interface [polypeptide binding]; other site
342451003250	active site
342451003251	Schiff base residues; other site
342451003252	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
342451003253	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
342451003254	inhibitor-cofactor binding pocket; inhibition site
342451003255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451003256	catalytic residue [active]
342451003257	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
342451003258	Putative ammonia monooxygenase; Region: AmoA; pfam05145
342451003259	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
342451003260	proline/glycine betaine transporter; Provisional; Region: PRK10642
342451003261	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
342451003262	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
342451003263	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342451003264	active site
342451003265	HIGH motif; other site
342451003266	nucleotide binding site [chemical binding]; other site
342451003267	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
342451003268	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
342451003269	active site
342451003270	KMSKS motif; other site
342451003271	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
342451003272	tRNA binding surface [nucleotide binding]; other site
342451003273	anticodon binding site; other site
342451003274	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
342451003275	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
342451003276	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342451003277	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
342451003278	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
342451003279	substrate binding pocket [chemical binding]; other site
342451003280	substrate-Mg2+ binding site; other site
342451003281	aspartate-rich region 1; other site
342451003282	aspartate-rich region 2; other site
342451003283	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
342451003284	hypothetical protein; Reviewed; Region: PRK00024
342451003285	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
342451003286	MPN+ (JAMM) motif; other site
342451003287	Zinc-binding site [ion binding]; other site
342451003288	rod shape-determining protein MreC; Provisional; Region: PRK13922
342451003289	rod shape-determining protein MreC; Region: MreC; pfam04085
342451003290	rod shape-determining protein MreD; Region: MreD; cl01087
342451003291	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
342451003292	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
342451003293	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
342451003294	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
342451003295	GTPase CgtA; Reviewed; Region: obgE; PRK12297
342451003296	GTP1/OBG; Region: GTP1_OBG; pfam01018
342451003297	Obg GTPase; Region: Obg; cd01898
342451003298	G1 box; other site
342451003299	GTP/Mg2+ binding site [chemical binding]; other site
342451003300	Switch I region; other site
342451003301	G2 box; other site
342451003302	G3 box; other site
342451003303	Switch II region; other site
342451003304	G4 box; other site
342451003305	G5 box; other site
342451003306	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
342451003307	hypothetical protein; Provisional; Region: PRK04435
342451003308	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
342451003309	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
342451003310	RuvA N terminal domain; Region: RuvA_N; pfam01330
342451003311	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
342451003312	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451003313	Walker A motif; other site
342451003314	ATP binding site [chemical binding]; other site
342451003315	Walker B motif; other site
342451003316	arginine finger; other site
342451003317	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
342451003318	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
342451003319	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
342451003320	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
342451003321	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
342451003322	Preprotein translocase subunit; Region: YajC; pfam02699
342451003323	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
342451003324	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
342451003325	Protein export membrane protein; Region: SecD_SecF; cl14618
342451003326	Protein export membrane protein; Region: SecD_SecF; pfam02355
342451003327	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
342451003328	DHH family; Region: DHH; pfam01368
342451003329	DHHA1 domain; Region: DHHA1; pfam02272
342451003330	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
342451003331	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451003332	active site
342451003333	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
342451003334	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
342451003335	Zn2+ binding site [ion binding]; other site
342451003336	Mg2+ binding site [ion binding]; other site
342451003337	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
342451003338	synthetase active site [active]
342451003339	NTP binding site [chemical binding]; other site
342451003340	metal binding site [ion binding]; metal-binding site
342451003341	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
342451003342	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
342451003343	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
342451003344	putative active site [active]
342451003345	dimerization interface [polypeptide binding]; other site
342451003346	putative tRNAtyr binding site [nucleotide binding]; other site
342451003347	Bacterial SH3 domain homologues; Region: SH3b; smart00287
342451003348	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
342451003349	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
342451003350	active site
342451003351	metal binding site [ion binding]; metal-binding site
342451003352	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
342451003353	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
342451003354	dimer interface [polypeptide binding]; other site
342451003355	motif 1; other site
342451003356	active site
342451003357	motif 2; other site
342451003358	motif 3; other site
342451003359	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
342451003360	anticodon binding site; other site
342451003361	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
342451003362	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
342451003363	dimer interface [polypeptide binding]; other site
342451003364	anticodon binding site; other site
342451003365	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
342451003366	homodimer interface [polypeptide binding]; other site
342451003367	motif 1; other site
342451003368	active site
342451003369	motif 2; other site
342451003370	GAD domain; Region: GAD; pfam02938
342451003371	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
342451003372	motif 3; other site
342451003373	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
342451003374	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
342451003375	putative ATP binding site [chemical binding]; other site
342451003376	putative substrate interface [chemical binding]; other site
342451003377	recombination factor protein RarA; Reviewed; Region: PRK13342
342451003378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451003379	Walker A motif; other site
342451003380	ATP binding site [chemical binding]; other site
342451003381	Walker B motif; other site
342451003382	arginine finger; other site
342451003383	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
342451003384	Predicted transcriptional regulator [Transcription]; Region: COG1959
342451003385	Transcriptional regulator; Region: Rrf2; pfam02082
342451003386	CsbD-like; Region: CsbD; pfam05532
342451003387	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
342451003388	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
342451003389	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451003390	Walker A/P-loop; other site
342451003391	ATP binding site [chemical binding]; other site
342451003392	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451003393	H-loop/switch region; other site
342451003394	ABC transporter; Region: ABC_tran_2; pfam12848
342451003395	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
342451003396	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
342451003397	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
342451003398	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
342451003399	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342451003400	catalytic residue [active]
342451003401	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
342451003402	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
342451003403	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
342451003404	binding surface
342451003405	TPR motif; other site
342451003406	TPR repeat; Region: TPR_11; pfam13414
342451003407	TPR repeat; Region: TPR_11; pfam13414
342451003408	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
342451003409	binding surface
342451003410	TPR motif; other site
342451003411	TPR repeat; Region: TPR_11; pfam13414
342451003412	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
342451003413	binding surface
342451003414	TPR motif; other site
342451003415	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
342451003416	AAA domain; Region: AAA_30; pfam13604
342451003417	Family description; Region: UvrD_C_2; pfam13538
342451003418	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
342451003419	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
342451003420	motif 1; other site
342451003421	active site
342451003422	motif 2; other site
342451003423	motif 3; other site
342451003424	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
342451003425	DHHA1 domain; Region: DHHA1; pfam02272
342451003426	hypothetical protein; Provisional; Region: PRK05473
342451003427	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
342451003428	hypothetical protein; Provisional; Region: PRK13678
342451003429	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
342451003430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451003431	S-adenosylmethionine binding site [chemical binding]; other site
342451003432	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
342451003433	Peptidase family U32; Region: Peptidase_U32; pfam01136
342451003434	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
342451003435	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
342451003436	Peptidase family U32; Region: Peptidase_U32; pfam01136
342451003437	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
342451003438	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
342451003439	Sugar specificity; other site
342451003440	Pyrimidine base specificity; other site
342451003441	ATP-binding site [chemical binding]; other site
342451003442	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
342451003443	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
342451003444	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
342451003445	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
342451003446	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
342451003447	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
342451003448	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
342451003449	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
342451003450	carboxyltransferase (CT) interaction site; other site
342451003451	biotinylation site [posttranslational modification]; other site
342451003452	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
342451003453	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
342451003454	ATP-grasp domain; Region: ATP-grasp_4; cl17255
342451003455	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
342451003456	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
342451003457	putative active site [active]
342451003458	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
342451003459	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
342451003460	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
342451003461	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
342451003462	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451003463	active site
342451003464	motif I; other site
342451003465	motif II; other site
342451003466	GTPase YqeH; Provisional; Region: PRK13796
342451003467	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
342451003468	GTP/Mg2+ binding site [chemical binding]; other site
342451003469	G4 box; other site
342451003470	G5 box; other site
342451003471	G1 box; other site
342451003472	Switch I region; other site
342451003473	G2 box; other site
342451003474	G3 box; other site
342451003475	Switch II region; other site
342451003476	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
342451003477	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
342451003478	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
342451003479	shikimate binding site; other site
342451003480	NAD(P) binding site [chemical binding]; other site
342451003481	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
342451003482	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
342451003483	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
342451003484	active site
342451003485	(T/H)XGH motif; other site
342451003486	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
342451003487	Zn2+ binding site [ion binding]; other site
342451003488	Mg2+ binding site [ion binding]; other site
342451003489	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
342451003490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451003491	S-adenosylmethionine binding site [chemical binding]; other site
342451003492	comEA protein; Region: comE; TIGR01259
342451003493	Helix-hairpin-helix motif; Region: HHH; pfam00633
342451003494	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
342451003495	catalytic motif [active]
342451003496	Zn binding site [ion binding]; other site
342451003497	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
342451003498	Competence protein; Region: Competence; pfam03772
342451003499	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
342451003500	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
342451003501	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
342451003502	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
342451003503	GTP-binding protein LepA; Provisional; Region: PRK05433
342451003504	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
342451003505	G1 box; other site
342451003506	putative GEF interaction site [polypeptide binding]; other site
342451003507	GTP/Mg2+ binding site [chemical binding]; other site
342451003508	Switch I region; other site
342451003509	G2 box; other site
342451003510	G3 box; other site
342451003511	Switch II region; other site
342451003512	G4 box; other site
342451003513	G5 box; other site
342451003514	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
342451003515	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
342451003516	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
342451003517	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
342451003518	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
342451003519	FeS/SAM binding site; other site
342451003520	HemN C-terminal domain; Region: HemN_C; pfam06969
342451003521	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
342451003522	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
342451003523	heat shock protein GrpE; Provisional; Region: PRK14140
342451003524	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
342451003525	dimer interface [polypeptide binding]; other site
342451003526	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
342451003527	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
342451003528	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
342451003529	nucleotide binding site [chemical binding]; other site
342451003530	NEF interaction site [polypeptide binding]; other site
342451003531	SBD interface [polypeptide binding]; other site
342451003532	chaperone protein DnaJ; Provisional; Region: PRK14280
342451003533	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
342451003534	HSP70 interaction site [polypeptide binding]; other site
342451003535	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
342451003536	substrate binding site [polypeptide binding]; other site
342451003537	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
342451003538	Zn binding sites [ion binding]; other site
342451003539	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
342451003540	dimer interface [polypeptide binding]; other site
342451003541	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
342451003542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451003543	S-adenosylmethionine binding site [chemical binding]; other site
342451003544	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
342451003545	RNA methyltransferase, RsmE family; Region: TIGR00046
342451003546	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
342451003547	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
342451003548	hypothetical protein; Provisional; Region: PRK13665
342451003549	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
342451003550	PhoH-like protein; Region: PhoH; pfam02562
342451003551	metal-binding heat shock protein; Provisional; Region: PRK00016
342451003552	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
342451003553	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
342451003554	active site
342451003555	catalytic motif [active]
342451003556	Zn binding site [ion binding]; other site
342451003557	GTPase Era; Reviewed; Region: era; PRK00089
342451003558	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
342451003559	G1 box; other site
342451003560	GTP/Mg2+ binding site [chemical binding]; other site
342451003561	Switch I region; other site
342451003562	G2 box; other site
342451003563	Switch II region; other site
342451003564	G3 box; other site
342451003565	G4 box; other site
342451003566	G5 box; other site
342451003567	KH domain; Region: KH_2; pfam07650
342451003568	Recombination protein O N terminal; Region: RecO_N; pfam11967
342451003569	DNA repair protein RecO; Region: reco; TIGR00613
342451003570	Recombination protein O C terminal; Region: RecO_C; pfam02565
342451003571	glycyl-tRNA synthetase; Provisional; Region: PRK04173
342451003572	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
342451003573	motif 1; other site
342451003574	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
342451003575	active site
342451003576	motif 2; other site
342451003577	motif 3; other site
342451003578	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
342451003579	anticodon binding site; other site
342451003580	HTH domain; Region: HTH_11; pfam08279
342451003581	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
342451003582	FOG: CBS domain [General function prediction only]; Region: COG0517
342451003583	PEP synthetase regulatory protein; Provisional; Region: PRK05339
342451003584	DNA primase, catalytic core; Region: dnaG; TIGR01391
342451003585	CHC2 zinc finger; Region: zf-CHC2; pfam01807
342451003586	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
342451003587	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
342451003588	active site
342451003589	metal binding site [ion binding]; metal-binding site
342451003590	interdomain interaction site; other site
342451003591	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
342451003592	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
342451003593	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
342451003594	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342451003595	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
342451003596	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
342451003597	DNA binding residues [nucleotide binding]
342451003598	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
342451003599	Family of unknown function (DUF633); Region: DUF633; pfam04816
342451003600	Uncharacterized conserved protein [Function unknown]; Region: COG0327
342451003601	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
342451003602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
342451003603	Uncharacterized conserved protein [Function unknown]; Region: COG0327
342451003604	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
342451003605	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
342451003606	DEAD-like helicases superfamily; Region: DEXDc; smart00487
342451003607	ATP binding site [chemical binding]; other site
342451003608	Mg++ binding site [ion binding]; other site
342451003609	motif III; other site
342451003610	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342451003611	nucleotide binding region [chemical binding]; other site
342451003612	ATP-binding site [chemical binding]; other site
342451003613	endonuclease IV; Provisional; Region: PRK01060
342451003614	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
342451003615	AP (apurinic/apyrimidinic) site pocket; other site
342451003616	DNA interaction; other site
342451003617	Metal-binding active site; metal-binding site
342451003618	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
342451003619	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
342451003620	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
342451003621	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
342451003622	ABC-ATPase subunit  interface; other site
342451003623	dimer interface [polypeptide binding]; other site
342451003624	putative PBP binding regions; other site
342451003625	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
342451003626	metal binding site 2 [ion binding]; metal-binding site
342451003627	putative DNA binding helix; other site
342451003628	metal binding site 1 [ion binding]; metal-binding site
342451003629	dimer interface [polypeptide binding]; other site
342451003630	structural Zn2+ binding site [ion binding]; other site
342451003631	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
342451003632	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
342451003633	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
342451003634	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
342451003635	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
342451003636	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
342451003637	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
342451003638	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
342451003639	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
342451003640	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
342451003641	Rhomboid family; Region: Rhomboid; pfam01694
342451003642	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
342451003643	binding surface
342451003644	TPR motif; other site
342451003645	TPR repeat; Region: TPR_11; pfam13414
342451003646	Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543
342451003647	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
342451003648	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
342451003649	nucleotide binding site [chemical binding]; other site
342451003650	Uncharacterized conserved protein [Function unknown]; Region: COG0011
342451003651	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
342451003652	Type II/IV secretion system protein; Region: T2SE; pfam00437
342451003653	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
342451003654	Walker A motif; other site
342451003655	ATP binding site [chemical binding]; other site
342451003656	Walker B motif; other site
342451003657	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
342451003658	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
342451003659	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
342451003660	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
342451003661	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
342451003662	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
342451003663	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
342451003664	ADP binding site [chemical binding]; other site
342451003665	magnesium binding site [ion binding]; other site
342451003666	putative shikimate binding site; other site
342451003667	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
342451003668	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
342451003669	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
342451003670	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
342451003671	tetramer interface [polypeptide binding]; other site
342451003672	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451003673	catalytic residue [active]
342451003674	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
342451003675	tetramer interface [polypeptide binding]; other site
342451003676	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451003677	catalytic residue [active]
342451003678	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
342451003679	active site residue [active]
342451003680	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
342451003681	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
342451003682	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
342451003683	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
342451003684	active site
342451003685	elongation factor P; Validated; Region: PRK00529
342451003686	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
342451003687	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
342451003688	RNA binding site [nucleotide binding]; other site
342451003689	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
342451003690	RNA binding site [nucleotide binding]; other site
342451003691	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
342451003692	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
342451003693	carboxyltransferase (CT) interaction site; other site
342451003694	biotinylation site [posttranslational modification]; other site
342451003695	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
342451003696	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
342451003697	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
342451003698	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
342451003699	Asp23 family; Region: Asp23; pfam03780
342451003700	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
342451003701	putative RNA binding site [nucleotide binding]; other site
342451003702	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
342451003703	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
342451003704	generic binding surface II; other site
342451003705	generic binding surface I; other site
342451003706	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
342451003707	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
342451003708	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
342451003709	substrate binding pocket [chemical binding]; other site
342451003710	chain length determination region; other site
342451003711	substrate-Mg2+ binding site; other site
342451003712	catalytic residues [active]
342451003713	aspartate-rich region 1; other site
342451003714	active site lid residues [active]
342451003715	aspartate-rich region 2; other site
342451003716	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
342451003717	arginine repressor; Provisional; Region: PRK04280
342451003718	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
342451003719	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
342451003720	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
342451003721	Walker A/P-loop; other site
342451003722	ATP binding site [chemical binding]; other site
342451003723	Q-loop/lid; other site
342451003724	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
342451003725	ABC transporter signature motif; other site
342451003726	Walker B; other site
342451003727	D-loop; other site
342451003728	H-loop/switch region; other site
342451003729	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
342451003730	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
342451003731	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
342451003732	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451003733	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
342451003734	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
342451003735	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
342451003736	tetramer interface [polypeptide binding]; other site
342451003737	TPP-binding site [chemical binding]; other site
342451003738	heterodimer interface [polypeptide binding]; other site
342451003739	phosphorylation loop region [posttranslational modification]
342451003740	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
342451003741	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
342451003742	alpha subunit interface [polypeptide binding]; other site
342451003743	TPP binding site [chemical binding]; other site
342451003744	heterodimer interface [polypeptide binding]; other site
342451003745	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
342451003746	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
342451003747	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
342451003748	E3 interaction surface; other site
342451003749	lipoyl attachment site [posttranslational modification]; other site
342451003750	e3 binding domain; Region: E3_binding; pfam02817
342451003751	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
342451003752	Disulphide isomerase; Region: Disulph_isomer; pfam06491
342451003753	Predicted membrane protein [Function unknown]; Region: COG4129
342451003754	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
342451003755	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
342451003756	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
342451003757	peptidase T-like protein; Region: PepT-like; TIGR01883
342451003758	metal binding site [ion binding]; metal-binding site
342451003759	putative dimer interface [polypeptide binding]; other site
342451003760	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
342451003761	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
342451003762	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
342451003763	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342451003764	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342451003765	DNA binding site [nucleotide binding]
342451003766	domain linker motif; other site
342451003767	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
342451003768	putative dimerization interface [polypeptide binding]; other site
342451003769	putative ligand binding site [chemical binding]; other site
342451003770	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
342451003771	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
342451003772	Ca binding site [ion binding]; other site
342451003773	active site
342451003774	catalytic site [active]
342451003775	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342451003776	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
342451003777	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
342451003778	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
342451003779	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
342451003780	ribonuclease Z; Region: RNase_Z; TIGR02651
342451003781	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
342451003782	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
342451003783	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
342451003784	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451003785	NAD(P) binding site [chemical binding]; other site
342451003786	active site
342451003787	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
342451003788	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342451003789	active site
342451003790	catalytic tetrad [active]
342451003791	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
342451003792	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
342451003793	dimer interface [polypeptide binding]; other site
342451003794	ADP-ribose binding site [chemical binding]; other site
342451003795	active site
342451003796	nudix motif; other site
342451003797	metal binding site [ion binding]; metal-binding site
342451003798	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
342451003799	metal binding site 2 [ion binding]; metal-binding site
342451003800	putative DNA binding helix; other site
342451003801	metal binding site 1 [ion binding]; metal-binding site
342451003802	dimer interface [polypeptide binding]; other site
342451003803	structural Zn2+ binding site [ion binding]; other site
342451003804	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
342451003805	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
342451003806	active site
342451003807	Int/Topo IB signature motif; other site
342451003808	Domain of unknown function (DUF309); Region: DUF309; cl00667
342451003809	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
342451003810	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
342451003811	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
342451003812	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342451003813	RNA binding surface [nucleotide binding]; other site
342451003814	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
342451003815	active site
342451003816	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342451003817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451003818	active site
342451003819	phosphorylation site [posttranslational modification]
342451003820	intermolecular recognition site; other site
342451003821	dimerization interface [polypeptide binding]; other site
342451003822	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
342451003823	DNA binding site [nucleotide binding]
342451003824	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
342451003825	dimerization interface [polypeptide binding]; other site
342451003826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
342451003827	dimer interface [polypeptide binding]; other site
342451003828	phosphorylation site [posttranslational modification]
342451003829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451003830	ATP binding site [chemical binding]; other site
342451003831	Mg2+ binding site [ion binding]; other site
342451003832	G-X-G motif; other site
342451003833	Predicted membrane protein [Function unknown]; Region: COG3601
342451003834	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
342451003835	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
342451003836	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
342451003837	DEAD-like helicases superfamily; Region: DEXDc; smart00487
342451003838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342451003839	ATP binding site [chemical binding]; other site
342451003840	putative Mg++ binding site [ion binding]; other site
342451003841	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342451003842	nucleotide binding region [chemical binding]; other site
342451003843	ATP-binding site [chemical binding]; other site
342451003844	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451003845	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
342451003846	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
342451003847	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451003848	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
342451003849	active site
342451003850	homotetramer interface [polypeptide binding]; other site
342451003851	homodimer interface [polypeptide binding]; other site
342451003852	cytidylate kinase; Provisional; Region: cmk; PRK00023
342451003853	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
342451003854	CMP-binding site; other site
342451003855	The sites determining sugar specificity; other site
342451003856	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
342451003857	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
342451003858	RNA binding site [nucleotide binding]; other site
342451003859	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
342451003860	RNA binding site [nucleotide binding]; other site
342451003861	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
342451003862	RNA binding site [nucleotide binding]; other site
342451003863	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
342451003864	RNA binding site [nucleotide binding]; other site
342451003865	GTP-binding protein Der; Reviewed; Region: PRK00093
342451003866	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
342451003867	G1 box; other site
342451003868	GTP/Mg2+ binding site [chemical binding]; other site
342451003869	Switch I region; other site
342451003870	G2 box; other site
342451003871	Switch II region; other site
342451003872	G3 box; other site
342451003873	G4 box; other site
342451003874	G5 box; other site
342451003875	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
342451003876	G1 box; other site
342451003877	GTP/Mg2+ binding site [chemical binding]; other site
342451003878	Switch I region; other site
342451003879	G2 box; other site
342451003880	G3 box; other site
342451003881	Switch II region; other site
342451003882	G4 box; other site
342451003883	G5 box; other site
342451003884	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
342451003885	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
342451003886	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
342451003887	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
342451003888	IHF dimer interface [polypeptide binding]; other site
342451003889	IHF - DNA interface [nucleotide binding]; other site
342451003890	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
342451003891	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
342451003892	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451003893	S-adenosylmethionine binding site [chemical binding]; other site
342451003894	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
342451003895	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
342451003896	substrate binding pocket [chemical binding]; other site
342451003897	chain length determination region; other site
342451003898	substrate-Mg2+ binding site; other site
342451003899	catalytic residues [active]
342451003900	aspartate-rich region 1; other site
342451003901	active site lid residues [active]
342451003902	aspartate-rich region 2; other site
342451003903	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
342451003904	active site
342451003905	multimer interface [polypeptide binding]; other site
342451003906	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
342451003907	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
342451003908	Tetramer interface [polypeptide binding]; other site
342451003909	active site
342451003910	FMN-binding site [chemical binding]; other site
342451003911	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
342451003912	active site
342451003913	dimer interface [polypeptide binding]; other site
342451003914	metal binding site [ion binding]; metal-binding site
342451003915	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
342451003916	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
342451003917	hinge; other site
342451003918	active site
342451003919	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
342451003920	binding surface
342451003921	TPR motif; other site
342451003922	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
342451003923	TPR motif; other site
342451003924	binding surface
342451003925	tetratricopeptide repeat protein; Provisional; Region: PRK11788
342451003926	Uncharacterized conserved protein [Function unknown]; Region: COG5582
342451003927	UPF0302 domain; Region: UPF0302; pfam08864
342451003928	IDEAL domain; Region: IDEAL; pfam08858
342451003929	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
342451003930	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
342451003931	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
342451003932	homodimer interface [polypeptide binding]; other site
342451003933	metal binding site [ion binding]; metal-binding site
342451003934	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
342451003935	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
342451003936	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
342451003937	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
342451003938	active site
342451003939	NTP binding site [chemical binding]; other site
342451003940	metal binding triad [ion binding]; metal-binding site
342451003941	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
342451003942	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
342451003943	Biotin operon repressor [Transcription]; Region: BirA; COG1654
342451003944	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
342451003945	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
342451003946	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
342451003947	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
342451003948	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
342451003949	active site
342451003950	catalytic site [active]
342451003951	substrate binding site [chemical binding]; other site
342451003952	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
342451003953	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
342451003954	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
342451003955	putative dimer interface [polypeptide binding]; other site
342451003956	putative anticodon binding site; other site
342451003957	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
342451003958	homodimer interface [polypeptide binding]; other site
342451003959	motif 1; other site
342451003960	motif 2; other site
342451003961	active site
342451003962	motif 3; other site
342451003963	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
342451003964	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
342451003965	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
342451003966	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
342451003967	minor groove reading motif; other site
342451003968	helix-hairpin-helix signature motif; other site
342451003969	substrate binding pocket [chemical binding]; other site
342451003970	active site
342451003971	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
342451003972	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
342451003973	Transglycosylase; Region: Transgly; pfam00912
342451003974	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
342451003975	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
342451003976	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
342451003977	hypothetical protein; Provisional; Region: PRK13660
342451003978	cell division protein GpsB; Provisional; Region: PRK14127
342451003979	DivIVA domain; Region: DivI1A_domain; TIGR03544
342451003980	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
342451003981	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
342451003982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
342451003983	rarD protein; Region: rarD; TIGR00688
342451003984	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
342451003985	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
342451003986	NADH(P)-binding; Region: NAD_binding_10; pfam13460
342451003987	putative NAD(P) binding site [chemical binding]; other site
342451003988	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
342451003989	amidase catalytic site [active]
342451003990	Zn binding residues [ion binding]; other site
342451003991	substrate binding site [chemical binding]; other site
342451003992	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
342451003993	Dynamin family; Region: Dynamin_N; pfam00350
342451003994	G1 box; other site
342451003995	GTP/Mg2+ binding site [chemical binding]; other site
342451003996	G2 box; other site
342451003997	Switch I region; other site
342451003998	G3 box; other site
342451003999	Switch II region; other site
342451004000	G4 box; other site
342451004001	G5 box; other site
342451004002	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
342451004003	Dynamin family; Region: Dynamin_N; pfam00350
342451004004	G1 box; other site
342451004005	GTP/Mg2+ binding site [chemical binding]; other site
342451004006	G2 box; other site
342451004007	Switch I region; other site
342451004008	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
342451004009	G3 box; other site
342451004010	Switch II region; other site
342451004011	GTP/Mg2+ binding site [chemical binding]; other site
342451004012	G4 box; other site
342451004013	G5 box; other site
342451004014	5'-3' exonuclease; Region: 53EXOc; smart00475
342451004015	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
342451004016	active site
342451004017	metal binding site 1 [ion binding]; metal-binding site
342451004018	putative 5' ssDNA interaction site; other site
342451004019	metal binding site 3; metal-binding site
342451004020	metal binding site 2 [ion binding]; metal-binding site
342451004021	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
342451004022	putative DNA binding site [nucleotide binding]; other site
342451004023	putative metal binding site [ion binding]; other site
342451004024	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
342451004025	RNA/DNA hybrid binding site [nucleotide binding]; other site
342451004026	active site
342451004027	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
342451004028	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342451004029	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
342451004030	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
342451004031	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
342451004032	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
342451004033	Virulence factor; Region: Virulence_fact; pfam13769
342451004034	HEAT repeats; Region: HEAT_2; pfam13646
342451004035	HEAT repeat; Region: HEAT; pfam02985
342451004036	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
342451004037	thymidylate synthase; Region: thym_sym; TIGR03284
342451004038	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
342451004039	dimerization interface [polypeptide binding]; other site
342451004040	active site
342451004041	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
342451004042	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
342451004043	folate binding site [chemical binding]; other site
342451004044	NADP+ binding site [chemical binding]; other site
342451004045	EDD domain protein, DegV family; Region: DegV; TIGR00762
342451004046	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
342451004047	methionine sulfoxide reductase A; Provisional; Region: PRK13014
342451004048	methionine sulfoxide reductase B; Provisional; Region: PRK00222
342451004049	SelR domain; Region: SelR; pfam01641
342451004050	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
342451004051	HPr interaction site; other site
342451004052	glycerol kinase (GK) interaction site [polypeptide binding]; other site
342451004053	active site
342451004054	phosphorylation site [posttranslational modification]
342451004055	hypothetical protein; Provisional; Region: PRK13672
342451004056	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
342451004057	C-terminal peptidase (prc); Region: prc; TIGR00225
342451004058	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
342451004059	protein binding site [polypeptide binding]; other site
342451004060	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
342451004061	Catalytic dyad [active]
342451004062	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
342451004063	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
342451004064	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
342451004065	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
342451004066	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
342451004067	active site
342451004068	homodimer interface [polypeptide binding]; other site
342451004069	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
342451004070	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
342451004071	active site
342451004072	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342451004073	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451004074	active site
342451004075	phosphorylation site [posttranslational modification]
342451004076	intermolecular recognition site; other site
342451004077	dimerization interface [polypeptide binding]; other site
342451004078	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
342451004079	DNA binding site [nucleotide binding]
342451004080	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342451004081	HAMP domain; Region: HAMP; pfam00672
342451004082	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
342451004083	dimer interface [polypeptide binding]; other site
342451004084	phosphorylation site [posttranslational modification]
342451004085	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451004086	ATP binding site [chemical binding]; other site
342451004087	Mg2+ binding site [ion binding]; other site
342451004088	G-X-G motif; other site
342451004089	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
342451004090	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
342451004091	TPP-binding site [chemical binding]; other site
342451004092	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
342451004093	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
342451004094	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
342451004095	E3 interaction surface; other site
342451004096	lipoyl attachment site [posttranslational modification]; other site
342451004097	e3 binding domain; Region: E3_binding; pfam02817
342451004098	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
342451004099	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
342451004100	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451004101	non-specific DNA binding site [nucleotide binding]; other site
342451004102	salt bridge; other site
342451004103	sequence-specific DNA binding site [nucleotide binding]; other site
342451004104	Cupin domain; Region: Cupin_2; pfam07883
342451004105	LysE type translocator; Region: LysE; cl00565
342451004106	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342451004107	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
342451004108	Cupin domain; Region: Cupin_2; cl17218
342451004109	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
342451004110	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
342451004111	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
342451004112	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
342451004113	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
342451004114	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
342451004115	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
342451004116	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
342451004117	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
342451004118	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
342451004119	RibD C-terminal domain; Region: RibD_C; cl17279
342451004120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451004121	Walker A/P-loop; other site
342451004122	ATP binding site [chemical binding]; other site
342451004123	ABC transporter; Region: ABC_tran; pfam00005
342451004124	Q-loop/lid; other site
342451004125	ABC transporter signature motif; other site
342451004126	Walker B; other site
342451004127	D-loop; other site
342451004128	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342451004129	active site
342451004130	MoxR-like ATPases [General function prediction only]; Region: COG0714
342451004131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451004132	Walker A motif; other site
342451004133	ATP binding site [chemical binding]; other site
342451004134	Walker B motif; other site
342451004135	arginine finger; other site
342451004136	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
342451004137	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
342451004138	metal ion-dependent adhesion site (MIDAS); other site
342451004139	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
342451004140	BCCT family transporter; Region: BCCT; pfam02028
342451004141	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
342451004142	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112
342451004143	acylphosphatase; Provisional; Region: PRK14431
342451004144	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
342451004145	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
342451004146	DNA-binding site [nucleotide binding]; DNA binding site
342451004147	RNA-binding motif; other site
342451004148	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
342451004149	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
342451004150	active site
342451004151	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342451004152	substrate binding site [chemical binding]; other site
342451004153	catalytic residues [active]
342451004154	dimer interface [polypeptide binding]; other site
342451004155	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
342451004156	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
342451004157	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342451004158	catalytic residue [active]
342451004159	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
342451004160	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
342451004161	metal binding site [ion binding]; metal-binding site
342451004162	dimer interface [polypeptide binding]; other site
342451004163	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
342451004164	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
342451004165	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
342451004166	active site
342451004167	trimer interface [polypeptide binding]; other site
342451004168	substrate binding site [chemical binding]; other site
342451004169	CoA binding site [chemical binding]; other site
342451004170	dihydrodipicolinate reductase; Provisional; Region: PRK00048
342451004171	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
342451004172	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
342451004173	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
342451004174	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
342451004175	dimer interface [polypeptide binding]; other site
342451004176	active site
342451004177	catalytic residue [active]
342451004178	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
342451004179	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
342451004180	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
342451004181	aspartate kinase; Reviewed; Region: PRK06635
342451004182	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
342451004183	putative nucleotide binding site [chemical binding]; other site
342451004184	putative catalytic residues [active]
342451004185	putative Mg ion binding site [ion binding]; other site
342451004186	putative aspartate binding site [chemical binding]; other site
342451004187	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
342451004188	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
342451004189	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
342451004190	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342451004191	active site
342451004192	catalytic tetrad [active]
342451004193	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
342451004194	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
342451004195	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
342451004196	ABC transporter; Region: ABC_tran_2; pfam12848
342451004197	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
342451004198	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
342451004199	S1 domain; Region: S1_2; pfam13509
342451004200	PBP superfamily domain; Region: PBP_like_2; cl17296
342451004201	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
342451004202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451004203	dimer interface [polypeptide binding]; other site
342451004204	conserved gate region; other site
342451004205	putative PBP binding loops; other site
342451004206	ABC-ATPase subunit interface; other site
342451004207	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
342451004208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451004209	dimer interface [polypeptide binding]; other site
342451004210	conserved gate region; other site
342451004211	putative PBP binding loops; other site
342451004212	ABC-ATPase subunit interface; other site
342451004213	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
342451004214	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
342451004215	Walker A/P-loop; other site
342451004216	ATP binding site [chemical binding]; other site
342451004217	Q-loop/lid; other site
342451004218	ABC transporter signature motif; other site
342451004219	Walker B; other site
342451004220	D-loop; other site
342451004221	H-loop/switch region; other site
342451004222	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
342451004223	PhoU domain; Region: PhoU; pfam01895
342451004224	PhoU domain; Region: PhoU; pfam01895
342451004225	oligoendopeptidase F; Region: pepF; TIGR00181
342451004226	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
342451004227	active site
342451004228	Zn binding site [ion binding]; other site
342451004229	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
342451004230	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
342451004231	intersubunit interface [polypeptide binding]; other site
342451004232	FemAB family; Region: FemAB; pfam02388
342451004233	FemAB family; Region: FemAB; pfam02388
342451004234	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
342451004235	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
342451004236	potential catalytic triad [active]
342451004237	conserved cys residue [active]
342451004238	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
342451004239	substrate binding site [chemical binding]; other site
342451004240	active site
342451004241	catalytic residues [active]
342451004242	heterodimer interface [polypeptide binding]; other site
342451004243	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
342451004244	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
342451004245	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451004246	catalytic residue [active]
342451004247	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
342451004248	active site
342451004249	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
342451004250	active site
342451004251	ribulose/triose binding site [chemical binding]; other site
342451004252	phosphate binding site [ion binding]; other site
342451004253	substrate (anthranilate) binding pocket [chemical binding]; other site
342451004254	product (indole) binding pocket [chemical binding]; other site
342451004255	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
342451004256	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
342451004257	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
342451004258	Glutamine amidotransferase class-I; Region: GATase; pfam00117
342451004259	glutamine binding [chemical binding]; other site
342451004260	catalytic triad [active]
342451004261	anthranilate synthase component I; Provisional; Region: PRK13567
342451004262	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
342451004263	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
342451004264	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
342451004265	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
342451004266	intersubunit interface [polypeptide binding]; other site
342451004267	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
342451004268	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
342451004269	putative oligomer interface [polypeptide binding]; other site
342451004270	putative active site [active]
342451004271	metal binding site [ion binding]; metal-binding site
342451004272	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
342451004273	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
342451004274	NAD binding site [chemical binding]; other site
342451004275	ligand binding site [chemical binding]; other site
342451004276	catalytic site [active]
342451004277	prephenate dehydrogenase; Validated; Region: PRK08507
342451004278	prephenate dehydrogenase; Validated; Region: PRK06545
342451004279	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
342451004280	DNA polymerase IV; Reviewed; Region: PRK03103
342451004281	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
342451004282	active site
342451004283	DNA binding site [nucleotide binding]
342451004284	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
342451004285	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
342451004286	active site 1 [active]
342451004287	dimer interface [polypeptide binding]; other site
342451004288	hexamer interface [polypeptide binding]; other site
342451004289	active site 2 [active]
342451004290	Transcriptional regulator [Transcription]; Region: LytR; COG1316
342451004291	methionine sulfoxide reductase A; Provisional; Region: PRK14054
342451004292	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
342451004293	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
342451004294	ligand binding site [chemical binding]; other site
342451004295	dimerization interface [polypeptide binding]; other site
342451004296	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
342451004297	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
342451004298	TM-ABC transporter signature motif; other site
342451004299	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
342451004300	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
342451004301	Walker A/P-loop; other site
342451004302	ATP binding site [chemical binding]; other site
342451004303	Q-loop/lid; other site
342451004304	ABC transporter signature motif; other site
342451004305	Walker B; other site
342451004306	D-loop; other site
342451004307	H-loop/switch region; other site
342451004308	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
342451004309	D-ribose pyranase; Provisional; Region: PRK11797
342451004310	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342451004311	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342451004312	DNA binding site [nucleotide binding]
342451004313	domain linker motif; other site
342451004314	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
342451004315	dimerization interface [polypeptide binding]; other site
342451004316	ligand binding site [chemical binding]; other site
342451004317	Predicted integral membrane protein [Function unknown]; Region: COG0392
342451004318	Uncharacterized conserved protein [Function unknown]; Region: COG2898
342451004319	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
342451004320	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
342451004321	Domain of unknown function DUF20; Region: UPF0118; pfam01594
342451004322	Acyltransferase family; Region: Acyl_transf_3; pfam01757
342451004323	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
342451004324	CAT RNA binding domain; Region: CAT_RBD; smart01061
342451004325	transcriptional antiterminator BglG; Provisional; Region: PRK09772
342451004326	PRD domain; Region: PRD; pfam00874
342451004327	PRD domain; Region: PRD; pfam00874
342451004328	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
342451004329	amino acid carrier protein; Region: agcS; TIGR00835
342451004330	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
342451004331	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
342451004332	CAP-like domain; other site
342451004333	active site
342451004334	primary dimer interface [polypeptide binding]; other site
342451004335	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342451004336	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
342451004337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451004338	ATP binding site [chemical binding]; other site
342451004339	Mg2+ binding site [ion binding]; other site
342451004340	G-X-G motif; other site
342451004341	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
342451004342	anchoring element; other site
342451004343	dimer interface [polypeptide binding]; other site
342451004344	ATP binding site [chemical binding]; other site
342451004345	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
342451004346	active site
342451004347	putative metal-binding site [ion binding]; other site
342451004348	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
342451004349	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
342451004350	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
342451004351	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
342451004352	active site
342451004353	aconitate hydratase; Validated; Region: PRK09277
342451004354	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
342451004355	substrate binding site [chemical binding]; other site
342451004356	ligand binding site [chemical binding]; other site
342451004357	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
342451004358	substrate binding site [chemical binding]; other site
342451004359	BCCT family transporter; Region: BCCT; pfam02028
342451004360	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
342451004361	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954
342451004362	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
342451004363	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
342451004364	Walker A/P-loop; other site
342451004365	ATP binding site [chemical binding]; other site
342451004366	Q-loop/lid; other site
342451004367	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
342451004368	ABC transporter signature motif; other site
342451004369	Walker B; other site
342451004370	D-loop; other site
342451004371	H-loop/switch region; other site
342451004372	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
342451004373	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
342451004374	active site
342451004375	metal binding site [ion binding]; metal-binding site
342451004376	DNA binding site [nucleotide binding]
342451004377	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
342451004378	Protein of unknown function (DUF1453); Region: DUF1453; cl02009
342451004379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
342451004380	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
342451004381	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
342451004382	TPP-binding site [chemical binding]; other site
342451004383	dimer interface [polypeptide binding]; other site
342451004384	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
342451004385	PYR/PP interface [polypeptide binding]; other site
342451004386	dimer interface [polypeptide binding]; other site
342451004387	TPP binding site [chemical binding]; other site
342451004388	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
342451004389	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
342451004390	LexA repressor; Validated; Region: PRK00215
342451004391	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
342451004392	putative DNA binding site [nucleotide binding]; other site
342451004393	putative Zn2+ binding site [ion binding]; other site
342451004394	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
342451004395	Catalytic site [active]
342451004396	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
342451004397	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
342451004398	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
342451004399	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
342451004400	active site
342451004401	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
342451004402	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
342451004403	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342451004404	Helix-turn-helix domain; Region: HTH_38; pfam13936
342451004405	Homeodomain-like domain; Region: HTH_32; pfam13565
342451004406	Integrase core domain; Region: rve; pfam00665
342451004407	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
342451004408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451004409	dimer interface [polypeptide binding]; other site
342451004410	conserved gate region; other site
342451004411	ABC-ATPase subunit interface; other site
342451004412	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
342451004413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451004414	dimer interface [polypeptide binding]; other site
342451004415	conserved gate region; other site
342451004416	ABC-ATPase subunit interface; other site
342451004417	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
342451004418	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
342451004419	Walker A/P-loop; other site
342451004420	ATP binding site [chemical binding]; other site
342451004421	Q-loop/lid; other site
342451004422	ABC transporter signature motif; other site
342451004423	Walker B; other site
342451004424	D-loop; other site
342451004425	H-loop/switch region; other site
342451004426	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
342451004427	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
342451004428	membrane-bound complex binding site; other site
342451004429	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
342451004430	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
342451004431	active site
342451004432	metal binding site [ion binding]; metal-binding site
342451004433	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
342451004434	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342451004435	Integrase core domain; Region: rve; pfam00665
342451004436	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
342451004437	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
342451004438	tetramer interface [polypeptide binding]; other site
342451004439	heme binding pocket [chemical binding]; other site
342451004440	NADPH binding site [chemical binding]; other site
342451004441	lysine transporter; Provisional; Region: PRK10836
342451004442	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
342451004443	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451004444	active site
342451004445	motif I; other site
342451004446	motif II; other site
342451004447	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451004448	homoserine kinase; Provisional; Region: PRK01212
342451004449	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
342451004450	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
342451004451	threonine synthase; Reviewed; Region: PRK06721
342451004452	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
342451004453	homodimer interface [polypeptide binding]; other site
342451004454	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451004455	catalytic residue [active]
342451004456	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
342451004457	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
342451004458	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
342451004459	aspartate kinase; Reviewed; Region: PRK09034
342451004460	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
342451004461	putative catalytic residues [active]
342451004462	putative nucleotide binding site [chemical binding]; other site
342451004463	putative aspartate binding site [chemical binding]; other site
342451004464	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
342451004465	allosteric regulatory residue; other site
342451004466	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
342451004467	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
342451004468	Staphylococcal nuclease homologues; Region: SNc; smart00318
342451004469	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
342451004470	Catalytic site; other site
342451004471	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
342451004472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451004473	active site
342451004474	phosphorylation site [posttranslational modification]
342451004475	intermolecular recognition site; other site
342451004476	dimerization interface [polypeptide binding]; other site
342451004477	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
342451004478	DNA binding residues [nucleotide binding]
342451004479	dimerization interface [polypeptide binding]; other site
342451004480	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
342451004481	Histidine kinase; Region: HisKA_3; pfam07730
342451004482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451004483	ATP binding site [chemical binding]; other site
342451004484	Mg2+ binding site [ion binding]; other site
342451004485	G-X-G motif; other site
342451004486	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
342451004487	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
342451004488	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
342451004489	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
342451004490	Walker A/P-loop; other site
342451004491	ATP binding site [chemical binding]; other site
342451004492	Q-loop/lid; other site
342451004493	ABC transporter signature motif; other site
342451004494	Walker B; other site
342451004495	D-loop; other site
342451004496	H-loop/switch region; other site
342451004497	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
342451004498	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
342451004499	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
342451004500	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
342451004501	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
342451004502	DNA binding residues [nucleotide binding]
342451004503	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
342451004504	Aluminium resistance protein; Region: Alum_res; pfam06838
342451004505	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
342451004506	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
342451004507	HflX GTPase family; Region: HflX; cd01878
342451004508	G1 box; other site
342451004509	GTP/Mg2+ binding site [chemical binding]; other site
342451004510	Switch I region; other site
342451004511	G2 box; other site
342451004512	G3 box; other site
342451004513	Switch II region; other site
342451004514	G4 box; other site
342451004515	G5 box; other site
342451004516	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
342451004517	catalytic residues [active]
342451004518	dimer interface [polypeptide binding]; other site
342451004519	bacterial Hfq-like; Region: Hfq; cd01716
342451004520	hexamer interface [polypeptide binding]; other site
342451004521	Sm1 motif; other site
342451004522	RNA binding site [nucleotide binding]; other site
342451004523	Sm2 motif; other site
342451004524	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
342451004525	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
342451004526	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
342451004527	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
342451004528	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
342451004529	glycerol kinase; Provisional; Region: glpK; PRK00047
342451004530	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
342451004531	N- and C-terminal domain interface [polypeptide binding]; other site
342451004532	active site
342451004533	MgATP binding site [chemical binding]; other site
342451004534	catalytic site [active]
342451004535	metal binding site [ion binding]; metal-binding site
342451004536	glycerol binding site [chemical binding]; other site
342451004537	homotetramer interface [polypeptide binding]; other site
342451004538	homodimer interface [polypeptide binding]; other site
342451004539	FBP binding site [chemical binding]; other site
342451004540	protein IIAGlc interface [polypeptide binding]; other site
342451004541	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
342451004542	amphipathic channel; other site
342451004543	Asn-Pro-Ala signature motifs; other site
342451004544	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
342451004545	putative dimer interface [polypeptide binding]; other site
342451004546	catalytic triad [active]
342451004547	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
342451004548	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
342451004549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451004550	ATP binding site [chemical binding]; other site
342451004551	Mg2+ binding site [ion binding]; other site
342451004552	G-X-G motif; other site
342451004553	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
342451004554	ATP binding site [chemical binding]; other site
342451004555	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
342451004556	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
342451004557	MutS domain I; Region: MutS_I; pfam01624
342451004558	MutS domain II; Region: MutS_II; pfam05188
342451004559	MutS domain III; Region: MutS_III; pfam05192
342451004560	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
342451004561	Walker A/P-loop; other site
342451004562	ATP binding site [chemical binding]; other site
342451004563	Q-loop/lid; other site
342451004564	ABC transporter signature motif; other site
342451004565	Walker B; other site
342451004566	D-loop; other site
342451004567	H-loop/switch region; other site
342451004568	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
342451004569	Predicted membrane protein [Function unknown]; Region: COG4550
342451004570	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
342451004571	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
342451004572	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
342451004573	FeS/SAM binding site; other site
342451004574	TRAM domain; Region: TRAM; pfam01938
342451004575	Uncharacterized conserved protein [Function unknown]; Region: COG0011
342451004576	Rrf2 family protein; Region: rrf2_super; TIGR00738
342451004577	Transcriptional regulator; Region: Rrf2; pfam02082
342451004578	Protein of unknown function (DUF867); Region: DUF867; cl01713
342451004579	Protein of unknown function (DUF867); Region: DUF867; cl01713
342451004580	Protein of unknown function (DUF867); Region: DUF867; pfam05908
342451004581	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
342451004582	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
342451004583	TPP-binding site [chemical binding]; other site
342451004584	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
342451004585	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
342451004586	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
342451004587	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
342451004588	dimer interface [polypeptide binding]; other site
342451004589	PYR/PP interface [polypeptide binding]; other site
342451004590	TPP binding site [chemical binding]; other site
342451004591	substrate binding site [chemical binding]; other site
342451004592	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
342451004593	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
342451004594	putative active site [active]
342451004595	metal binding site [ion binding]; metal-binding site
342451004596	homodimer binding site [polypeptide binding]; other site
342451004597	phosphodiesterase; Provisional; Region: PRK12704
342451004598	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
342451004599	Zn2+ binding site [ion binding]; other site
342451004600	Mg2+ binding site [ion binding]; other site
342451004601	recombinase A; Provisional; Region: recA; PRK09354
342451004602	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
342451004603	hexamer interface [polypeptide binding]; other site
342451004604	Walker A motif; other site
342451004605	ATP binding site [chemical binding]; other site
342451004606	Walker B motif; other site
342451004607	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
342451004608	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
342451004609	putative MPT binding site; other site
342451004610	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
342451004611	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
342451004612	Helix-turn-helix domain; Region: HTH_25; pfam13413
342451004613	non-specific DNA binding site [nucleotide binding]; other site
342451004614	salt bridge; other site
342451004615	sequence-specific DNA binding site [nucleotide binding]; other site
342451004616	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
342451004617	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
342451004618	classical (c) SDRs; Region: SDR_c; cd05233
342451004619	NAD(P) binding site [chemical binding]; other site
342451004620	active site
342451004621	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
342451004622	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
342451004623	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
342451004624	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
342451004625	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
342451004626	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
342451004627	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
342451004628	DNA-binding site [nucleotide binding]; DNA binding site
342451004629	UTRA domain; Region: UTRA; pfam07702
342451004630	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
342451004631	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
342451004632	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
342451004633	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
342451004634	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
342451004635	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
342451004636	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
342451004637	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
342451004638	RNase E interface [polypeptide binding]; other site
342451004639	trimer interface [polypeptide binding]; other site
342451004640	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
342451004641	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
342451004642	RNase E interface [polypeptide binding]; other site
342451004643	trimer interface [polypeptide binding]; other site
342451004644	active site
342451004645	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
342451004646	putative nucleic acid binding region [nucleotide binding]; other site
342451004647	G-X-X-G motif; other site
342451004648	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
342451004649	RNA binding site [nucleotide binding]; other site
342451004650	domain interface; other site
342451004651	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
342451004652	16S/18S rRNA binding site [nucleotide binding]; other site
342451004653	S13e-L30e interaction site [polypeptide binding]; other site
342451004654	25S rRNA binding site [nucleotide binding]; other site
342451004655	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
342451004656	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
342451004657	active site
342451004658	Riboflavin kinase; Region: Flavokinase; smart00904
342451004659	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
342451004660	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
342451004661	RNA binding site [nucleotide binding]; other site
342451004662	active site
342451004663	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
342451004664	HTH domain; Region: HTH_11; cl17392
342451004665	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
342451004666	translation initiation factor IF-2; Region: IF-2; TIGR00487
342451004667	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
342451004668	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
342451004669	G1 box; other site
342451004670	putative GEF interaction site [polypeptide binding]; other site
342451004671	GTP/Mg2+ binding site [chemical binding]; other site
342451004672	Switch I region; other site
342451004673	G2 box; other site
342451004674	G3 box; other site
342451004675	Switch II region; other site
342451004676	G4 box; other site
342451004677	G5 box; other site
342451004678	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
342451004679	Translation-initiation factor 2; Region: IF-2; pfam11987
342451004680	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
342451004681	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
342451004682	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
342451004683	putative RNA binding cleft [nucleotide binding]; other site
342451004684	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
342451004685	NusA N-terminal domain; Region: NusA_N; pfam08529
342451004686	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
342451004687	RNA binding site [nucleotide binding]; other site
342451004688	homodimer interface [polypeptide binding]; other site
342451004689	NusA-like KH domain; Region: KH_5; pfam13184
342451004690	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
342451004691	G-X-X-G motif; other site
342451004692	ribosome maturation protein RimP; Reviewed; Region: PRK00092
342451004693	Sm and related proteins; Region: Sm_like; cl00259
342451004694	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
342451004695	putative oligomer interface [polypeptide binding]; other site
342451004696	putative RNA binding site [nucleotide binding]; other site
342451004697	DNA polymerase III PolC; Validated; Region: polC; PRK00448
342451004698	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
342451004699	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
342451004700	generic binding surface II; other site
342451004701	generic binding surface I; other site
342451004702	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
342451004703	active site
342451004704	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
342451004705	active site
342451004706	catalytic site [active]
342451004707	substrate binding site [chemical binding]; other site
342451004708	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
342451004709	prolyl-tRNA synthetase; Provisional; Region: PRK09194
342451004710	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
342451004711	dimer interface [polypeptide binding]; other site
342451004712	motif 1; other site
342451004713	active site
342451004714	motif 2; other site
342451004715	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
342451004716	putative deacylase active site [active]
342451004717	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
342451004718	active site
342451004719	motif 3; other site
342451004720	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
342451004721	anticodon binding site; other site
342451004722	RIP metalloprotease RseP; Region: TIGR00054
342451004723	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
342451004724	active site
342451004725	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
342451004726	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
342451004727	protein binding site [polypeptide binding]; other site
342451004728	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
342451004729	putative substrate binding region [chemical binding]; other site
342451004730	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
342451004731	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
342451004732	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
342451004733	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
342451004734	catalytic residue [active]
342451004735	putative FPP diphosphate  binding site; other site
342451004736	putative FPP binding hydrophobic cleft; other site
342451004737	dimer interface [polypeptide binding]; other site
342451004738	putative IPP diphosphate binding site; other site
342451004739	ribosome recycling factor; Reviewed; Region: frr; PRK00083
342451004740	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
342451004741	hinge region; other site
342451004742	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
342451004743	putative nucleotide binding site [chemical binding]; other site
342451004744	uridine monophosphate binding site [chemical binding]; other site
342451004745	homohexameric interface [polypeptide binding]; other site
342451004746	elongation factor Ts; Provisional; Region: tsf; PRK09377
342451004747	UBA/TS-N domain; Region: UBA; pfam00627
342451004748	Elongation factor TS; Region: EF_TS; pfam00889
342451004749	Elongation factor TS; Region: EF_TS; pfam00889
342451004750	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
342451004751	rRNA interaction site [nucleotide binding]; other site
342451004752	S8 interaction site; other site
342451004753	putative laminin-1 binding site; other site
342451004754	transcriptional repressor CodY; Validated; Region: PRK04158
342451004755	CodY GAF-like domain; Region: CodY; pfam06018
342451004756	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
342451004757	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
342451004758	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451004759	Walker A motif; other site
342451004760	ATP binding site [chemical binding]; other site
342451004761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451004762	Walker B motif; other site
342451004763	arginine finger; other site
342451004764	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
342451004765	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
342451004766	active site
342451004767	HslU subunit interaction site [polypeptide binding]; other site
342451004768	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
342451004769	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
342451004770	active site
342451004771	DNA binding site [nucleotide binding]
342451004772	Int/Topo IB signature motif; other site
342451004773	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
342451004774	Glucose inhibited division protein A; Region: GIDA; pfam01134
342451004775	DNA topoisomerase I; Validated; Region: PRK05582
342451004776	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
342451004777	active site
342451004778	interdomain interaction site; other site
342451004779	putative metal-binding site [ion binding]; other site
342451004780	nucleotide binding site [chemical binding]; other site
342451004781	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
342451004782	domain I; other site
342451004783	DNA binding groove [nucleotide binding]
342451004784	phosphate binding site [ion binding]; other site
342451004785	domain II; other site
342451004786	domain III; other site
342451004787	nucleotide binding site [chemical binding]; other site
342451004788	catalytic site [active]
342451004789	domain IV; other site
342451004790	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
342451004791	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
342451004792	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
342451004793	DNA protecting protein DprA; Region: dprA; TIGR00732
342451004794	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
342451004795	CoA binding domain; Region: CoA_binding; smart00881
342451004796	CoA-ligase; Region: Ligase_CoA; pfam00549
342451004797	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
342451004798	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
342451004799	CoA-ligase; Region: Ligase_CoA; pfam00549
342451004800	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
342451004801	RNA/DNA hybrid binding site [nucleotide binding]; other site
342451004802	active site
342451004803	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
342451004804	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
342451004805	GTP/Mg2+ binding site [chemical binding]; other site
342451004806	G4 box; other site
342451004807	G5 box; other site
342451004808	G1 box; other site
342451004809	Switch I region; other site
342451004810	G2 box; other site
342451004811	G3 box; other site
342451004812	Switch II region; other site
342451004813	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
342451004814	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
342451004815	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
342451004816	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
342451004817	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
342451004818	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
342451004819	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
342451004820	RimM N-terminal domain; Region: RimM; pfam01782
342451004821	PRC-barrel domain; Region: PRC; pfam05239
342451004822	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
342451004823	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
342451004824	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451004825	NAD(P) binding site [chemical binding]; other site
342451004826	active site
342451004827	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
342451004828	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
342451004829	active site
342451004830	non-prolyl cis peptide bond; other site
342451004831	signal recognition particle protein; Provisional; Region: PRK10867
342451004832	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
342451004833	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
342451004834	P loop; other site
342451004835	GTP binding site [chemical binding]; other site
342451004836	Signal peptide binding domain; Region: SRP_SPB; pfam02978
342451004837	putative DNA-binding protein; Validated; Region: PRK00118
342451004838	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
342451004839	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
342451004840	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
342451004841	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
342451004842	P loop; other site
342451004843	GTP binding site [chemical binding]; other site
342451004844	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
342451004845	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
342451004846	Walker A/P-loop; other site
342451004847	ATP binding site [chemical binding]; other site
342451004848	Q-loop/lid; other site
342451004849	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
342451004850	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
342451004851	ABC transporter signature motif; other site
342451004852	Walker B; other site
342451004853	D-loop; other site
342451004854	H-loop/switch region; other site
342451004855	ribonuclease III; Reviewed; Region: rnc; PRK00102
342451004856	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
342451004857	dimerization interface [polypeptide binding]; other site
342451004858	active site
342451004859	metal binding site [ion binding]; metal-binding site
342451004860	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
342451004861	dsRNA binding site [nucleotide binding]; other site
342451004862	acyl carrier protein; Provisional; Region: acpP; PRK00982
342451004863	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
342451004864	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
342451004865	NAD(P) binding site [chemical binding]; other site
342451004866	homotetramer interface [polypeptide binding]; other site
342451004867	homodimer interface [polypeptide binding]; other site
342451004868	active site
342451004869	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
342451004870	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
342451004871	putative phosphate acyltransferase; Provisional; Region: PRK05331
342451004872	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
342451004873	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
342451004874	active site 2 [active]
342451004875	active site 1 [active]
342451004876	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
342451004877	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
342451004878	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
342451004879	active site
342451004880	Zn binding site [ion binding]; other site
342451004881	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
342451004882	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
342451004883	generic binding surface II; other site
342451004884	ssDNA binding site; other site
342451004885	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342451004886	ATP binding site [chemical binding]; other site
342451004887	putative Mg++ binding site [ion binding]; other site
342451004888	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342451004889	nucleotide binding region [chemical binding]; other site
342451004890	ATP-binding site [chemical binding]; other site
342451004891	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
342451004892	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
342451004893	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
342451004894	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
342451004895	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
342451004896	putative L-serine binding site [chemical binding]; other site
342451004897	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
342451004898	DAK2 domain; Region: Dak2; pfam02734
342451004899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
342451004900	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
342451004901	Thiamine pyrophosphokinase; Region: TPK; cd07995
342451004902	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
342451004903	active site
342451004904	dimerization interface [polypeptide binding]; other site
342451004905	thiamine binding site [chemical binding]; other site
342451004906	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
342451004907	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
342451004908	substrate binding site [chemical binding]; other site
342451004909	hexamer interface [polypeptide binding]; other site
342451004910	metal binding site [ion binding]; metal-binding site
342451004911	GTPase RsgA; Reviewed; Region: PRK00098
342451004912	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
342451004913	RNA binding site [nucleotide binding]; other site
342451004914	homodimer interface [polypeptide binding]; other site
342451004915	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
342451004916	GTPase/Zn-binding domain interface [polypeptide binding]; other site
342451004917	GTP/Mg2+ binding site [chemical binding]; other site
342451004918	G4 box; other site
342451004919	G5 box; other site
342451004920	G1 box; other site
342451004921	Switch I region; other site
342451004922	G2 box; other site
342451004923	G3 box; other site
342451004924	Switch II region; other site
342451004925	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342451004926	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
342451004927	active site
342451004928	ATP binding site [chemical binding]; other site
342451004929	substrate binding site [chemical binding]; other site
342451004930	activation loop (A-loop); other site
342451004931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
342451004932	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
342451004933	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
342451004934	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
342451004935	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
342451004936	Protein phosphatase 2C; Region: PP2C; pfam00481
342451004937	active site
342451004938	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
342451004939	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
342451004940	FeS/SAM binding site; other site
342451004941	16S rRNA methyltransferase B; Provisional; Region: PRK14902
342451004942	NusB family; Region: NusB; pfam01029
342451004943	putative RNA binding site [nucleotide binding]; other site
342451004944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451004945	S-adenosylmethionine binding site [chemical binding]; other site
342451004946	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
342451004947	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
342451004948	putative active site [active]
342451004949	substrate binding site [chemical binding]; other site
342451004950	putative cosubstrate binding site; other site
342451004951	catalytic site [active]
342451004952	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
342451004953	substrate binding site [chemical binding]; other site
342451004954	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
342451004955	active site
342451004956	catalytic residues [active]
342451004957	metal binding site [ion binding]; metal-binding site
342451004958	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
342451004959	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
342451004960	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
342451004961	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342451004962	ATP binding site [chemical binding]; other site
342451004963	putative Mg++ binding site [ion binding]; other site
342451004964	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342451004965	nucleotide binding region [chemical binding]; other site
342451004966	ATP-binding site [chemical binding]; other site
342451004967	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
342451004968	Flavoprotein; Region: Flavoprotein; pfam02441
342451004969	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
342451004970	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
342451004971	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
342451004972	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
342451004973	catalytic site [active]
342451004974	G-X2-G-X-G-K; other site
342451004975	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
342451004976	Domain of unknown function (DUF814); Region: DUF814; pfam05670
342451004977	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
342451004978	dimer interface [polypeptide binding]; other site
342451004979	Uncharacterized conserved protein [Function unknown]; Region: COG1284
342451004980	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
342451004981	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
342451004982	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451004983	active site
342451004984	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
342451004985	active site
342451004986	dimer interface [polypeptide binding]; other site
342451004987	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
342451004988	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
342451004989	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
342451004990	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
342451004991	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
342451004992	ATP-grasp domain; Region: ATP-grasp_4; cl17255
342451004993	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
342451004994	IMP binding site; other site
342451004995	dimer interface [polypeptide binding]; other site
342451004996	interdomain contacts; other site
342451004997	partial ornithine binding site; other site
342451004998	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
342451004999	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
342451005000	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
342451005001	catalytic site [active]
342451005002	subunit interface [polypeptide binding]; other site
342451005003	dihydroorotase; Validated; Region: pyrC; PRK09357
342451005004	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
342451005005	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
342451005006	active site
342451005007	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
342451005008	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
342451005009	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
342451005010	uracil-xanthine permease; Region: ncs2; TIGR00801
342451005011	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
342451005012	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451005013	active site
342451005014	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
342451005015	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342451005016	RNA binding surface [nucleotide binding]; other site
342451005017	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
342451005018	active site
342451005019	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
342451005020	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
342451005021	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342451005022	active site
342451005023	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
342451005024	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
342451005025	HIGH motif; other site
342451005026	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
342451005027	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
342451005028	active site
342451005029	KMSKS motif; other site
342451005030	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
342451005031	tRNA binding surface [nucleotide binding]; other site
342451005032	anticodon binding site; other site
342451005033	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
342451005034	DivIVA protein; Region: DivIVA; pfam05103
342451005035	DivIVA domain; Region: DivI1A_domain; TIGR03544
342451005036	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
342451005037	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342451005038	RNA binding surface [nucleotide binding]; other site
342451005039	YGGT family; Region: YGGT; pfam02325
342451005040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
342451005041	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
342451005042	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342451005043	catalytic residue [active]
342451005044	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
342451005045	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
342451005046	cell division protein FtsZ; Validated; Region: PRK09330
342451005047	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
342451005048	nucleotide binding site [chemical binding]; other site
342451005049	SulA interaction site; other site
342451005050	cell division protein FtsA; Region: ftsA; TIGR01174
342451005051	Cell division protein FtsA; Region: FtsA; smart00842
342451005052	Cell division protein FtsA; Region: FtsA; pfam14450
342451005053	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
342451005054	Cell division protein FtsQ; Region: FtsQ; pfam03799
342451005055	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
342451005056	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
342451005057	NAD binding site [chemical binding]; other site
342451005058	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342451005059	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
342451005060	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
342451005061	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
342451005062	Mg++ binding site [ion binding]; other site
342451005063	putative catalytic motif [active]
342451005064	putative substrate binding site [chemical binding]; other site
342451005065	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
342451005066	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
342451005067	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
342451005068	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
342451005069	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
342451005070	Cell division protein FtsL; Region: FtsL; cl11433
342451005071	MraW methylase family; Region: Methyltransf_5; pfam01795
342451005072	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
342451005073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
342451005074	MraZ protein; Region: MraZ; pfam02381
342451005075	MraZ protein; Region: MraZ; pfam02381
342451005076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
342451005077	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
342451005078	hypothetical protein; Provisional; Region: PRK13688
342451005079	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
342451005080	Coenzyme A binding pocket [chemical binding]; other site
342451005081	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
342451005082	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451005083	motif II; other site
342451005084	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
342451005085	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
342451005086	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
342451005087	active site
342451005088	topology modulation protein; Reviewed; Region: PRK08118
342451005089	AAA domain; Region: AAA_17; pfam13207
342451005090	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
342451005091	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
342451005092	metal-binding site [ion binding]
342451005093	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
342451005094	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
342451005095	metal-binding site [ion binding]
342451005096	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
342451005097	Soluble P-type ATPase [General function prediction only]; Region: COG4087
342451005098	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
342451005099	dimerization interface [polypeptide binding]; other site
342451005100	putative DNA binding site [nucleotide binding]; other site
342451005101	putative Zn2+ binding site [ion binding]; other site
342451005102	putative transposase OrfB; Reviewed; Region: PHA02517
342451005103	HTH-like domain; Region: HTH_21; pfam13276
342451005104	Integrase core domain; Region: rve; pfam00665
342451005105	Integrase core domain; Region: rve_2; pfam13333
342451005106	Helix-turn-helix domain; Region: HTH_28; pfam13518
342451005107	Winged helix-turn helix; Region: HTH_29; pfam13551
342451005108	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
342451005109	Helix-turn-helix domain; Region: HTH_28; pfam13518
342451005110	YolD-like protein; Region: YolD; pfam08863
342451005111	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
342451005112	Integrase core domain; Region: rve; pfam00665
342451005113	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
342451005114	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
342451005115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451005116	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
342451005117	tetramer interface [polypeptide binding]; other site
342451005118	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
342451005119	active site
342451005120	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
342451005121	active site
342451005122	dimer interface [polypeptide binding]; other site
342451005123	magnesium binding site [ion binding]; other site
342451005124	Predicted transcriptional regulators [Transcription]; Region: COG1733
342451005125	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
342451005126	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
342451005127	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342451005128	DNA-binding site [nucleotide binding]; DNA binding site
342451005129	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342451005130	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451005131	homodimer interface [polypeptide binding]; other site
342451005132	catalytic residue [active]
342451005133	EamA-like transporter family; Region: EamA; pfam00892
342451005134	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
342451005135	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
342451005136	NAD binding site [chemical binding]; other site
342451005137	catalytic Zn binding site [ion binding]; other site
342451005138	structural Zn binding site [ion binding]; other site
342451005139	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451005140	Walker A/P-loop; other site
342451005141	ATP binding site [chemical binding]; other site
342451005142	Q-loop/lid; other site
342451005143	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451005144	ABC transporter signature motif; other site
342451005145	Walker B; other site
342451005146	D-loop; other site
342451005147	H-loop/switch region; other site
342451005148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451005149	AAA domain; Region: AAA_21; pfam13304
342451005150	Walker A/P-loop; other site
342451005151	ATP binding site [chemical binding]; other site
342451005152	Q-loop/lid; other site
342451005153	ABC transporter signature motif; other site
342451005154	Walker B; other site
342451005155	D-loop; other site
342451005156	H-loop/switch region; other site
342451005157	intracellular protease, PfpI family; Region: PfpI; TIGR01382
342451005158	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
342451005159	proposed catalytic triad [active]
342451005160	conserved cys residue [active]
342451005161	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
342451005162	active site
342451005163	dimer interface [polypeptide binding]; other site
342451005164	magnesium binding site [ion binding]; other site
342451005165	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
342451005166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451005167	NAD(P) binding site [chemical binding]; other site
342451005168	active site
342451005169	Predicted transcriptional regulators [Transcription]; Region: COG1733
342451005170	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
342451005171	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
342451005172	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
342451005173	NAD binding site [chemical binding]; other site
342451005174	catalytic residues [active]
342451005175	substrate binding site [chemical binding]; other site
342451005176	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
342451005177	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
342451005178	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
342451005179	Low molecular weight phosphatase family; Region: LMWPc; cd00115
342451005180	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
342451005181	active site
342451005182	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
342451005183	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
342451005184	putative NAD(P) binding site [chemical binding]; other site
342451005185	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451005186	MarR family; Region: MarR; pfam01047
342451005187	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
342451005188	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451005189	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
342451005190	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
342451005191	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
342451005192	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
342451005193	substrate binding pocket [chemical binding]; other site
342451005194	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
342451005195	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
342451005196	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
342451005197	Integrase core domain; Region: rve; pfam00665
342451005198	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
342451005199	Int/Topo IB signature motif; other site
342451005200	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
342451005201	active site
342451005202	metal binding site [ion binding]; metal-binding site
342451005203	homotetramer interface [polypeptide binding]; other site
342451005204	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
342451005205	active site
342451005206	dimerization interface [polypeptide binding]; other site
342451005207	glutamate racemase; Provisional; Region: PRK00865
342451005208	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
342451005209	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
342451005210	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
342451005211	L-aspartate oxidase; Provisional; Region: PRK06175
342451005212	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
342451005213	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
342451005214	putative Iron-sulfur protein interface [polypeptide binding]; other site
342451005215	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
342451005216	proximal heme binding site [chemical binding]; other site
342451005217	distal heme binding site [chemical binding]; other site
342451005218	putative dimer interface [polypeptide binding]; other site
342451005219	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
342451005220	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
342451005221	GIY-YIG motif/motif A; other site
342451005222	active site
342451005223	catalytic site [active]
342451005224	putative DNA binding site [nucleotide binding]; other site
342451005225	metal binding site [ion binding]; metal-binding site
342451005226	UvrB/uvrC motif; Region: UVR; pfam02151
342451005227	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
342451005228	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
342451005229	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
342451005230	catalytic residues [active]
342451005231	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
342451005232	MutS domain III; Region: MutS_III; pfam05192
342451005233	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
342451005234	Walker A/P-loop; other site
342451005235	ATP binding site [chemical binding]; other site
342451005236	Q-loop/lid; other site
342451005237	ABC transporter signature motif; other site
342451005238	Walker B; other site
342451005239	D-loop; other site
342451005240	H-loop/switch region; other site
342451005241	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
342451005242	Smr domain; Region: Smr; pfam01713
342451005243	hypothetical protein; Provisional; Region: PRK08609
342451005244	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
342451005245	active site
342451005246	primer binding site [nucleotide binding]; other site
342451005247	NTP  binding site [chemical binding]; other site
342451005248	metal binding triad [ion binding]; metal-binding site
342451005249	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
342451005250	active site
342451005251	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
342451005252	Colicin V production protein; Region: Colicin_V; pfam02674
342451005253	Cell division protein ZapA; Region: ZapA; cl01146
342451005254	ribonuclease HIII; Provisional; Region: PRK00996
342451005255	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
342451005256	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
342451005257	RNA/DNA hybrid binding site [nucleotide binding]; other site
342451005258	active site
342451005259	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
342451005260	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
342451005261	putative tRNA-binding site [nucleotide binding]; other site
342451005262	B3/4 domain; Region: B3_4; pfam03483
342451005263	tRNA synthetase B5 domain; Region: B5; smart00874
342451005264	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
342451005265	dimer interface [polypeptide binding]; other site
342451005266	motif 1; other site
342451005267	motif 3; other site
342451005268	motif 2; other site
342451005269	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
342451005270	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
342451005271	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
342451005272	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
342451005273	dimer interface [polypeptide binding]; other site
342451005274	motif 1; other site
342451005275	active site
342451005276	motif 2; other site
342451005277	motif 3; other site
342451005278	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
342451005279	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
342451005280	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
342451005281	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
342451005282	Peptidase family M23; Region: Peptidase_M23; pfam01551
342451005283	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
342451005284	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
342451005285	hypothetical protein; Provisional; Region: PRK13670
342451005286	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
342451005287	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
342451005288	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
342451005289	active site
342451005290	(T/H)XGH motif; other site
342451005291	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
342451005292	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451005293	S-adenosylmethionine binding site [chemical binding]; other site
342451005294	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902
342451005295	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
342451005296	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
342451005297	putative active site [active]
342451005298	catalytic site [active]
342451005299	putative metal binding site [ion binding]; other site
342451005300	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
342451005301	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
342451005302	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
342451005303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451005304	Walker A/P-loop; other site
342451005305	ATP binding site [chemical binding]; other site
342451005306	Q-loop/lid; other site
342451005307	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
342451005308	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
342451005309	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451005310	Walker A/P-loop; other site
342451005311	ATP binding site [chemical binding]; other site
342451005312	Q-loop/lid; other site
342451005313	ABC transporter signature motif; other site
342451005314	Walker B; other site
342451005315	D-loop; other site
342451005316	H-loop/switch region; other site
342451005317	Protein of unknown function (DUF420); Region: DUF420; pfam04238
342451005318	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
342451005319	UbiA prenyltransferase family; Region: UbiA; pfam01040
342451005320	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
342451005321	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
342451005322	pyruvate carboxylase; Reviewed; Region: PRK12999
342451005323	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
342451005324	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
342451005325	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
342451005326	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
342451005327	active site
342451005328	catalytic residues [active]
342451005329	metal binding site [ion binding]; metal-binding site
342451005330	homodimer binding site [polypeptide binding]; other site
342451005331	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
342451005332	carboxyltransferase (CT) interaction site; other site
342451005333	biotinylation site [posttranslational modification]; other site
342451005334	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
342451005335	hypothetical protein; Provisional; Region: PRK13666
342451005336	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
342451005337	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
342451005338	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
342451005339	G1 box; other site
342451005340	putative GEF interaction site [polypeptide binding]; other site
342451005341	GTP/Mg2+ binding site [chemical binding]; other site
342451005342	Switch I region; other site
342451005343	G2 box; other site
342451005344	G3 box; other site
342451005345	Switch II region; other site
342451005346	G4 box; other site
342451005347	G5 box; other site
342451005348	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
342451005349	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
342451005350	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
342451005351	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
342451005352	active site
342451005353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
342451005354	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
342451005355	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
342451005356	manganese transport protein MntH; Reviewed; Region: PRK00701
342451005357	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
342451005358	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
342451005359	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
342451005360	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
342451005361	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
342451005362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451005363	dimer interface [polypeptide binding]; other site
342451005364	conserved gate region; other site
342451005365	putative PBP binding loops; other site
342451005366	ABC-ATPase subunit interface; other site
342451005367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451005368	dimer interface [polypeptide binding]; other site
342451005369	conserved gate region; other site
342451005370	putative PBP binding loops; other site
342451005371	ABC-ATPase subunit interface; other site
342451005372	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
342451005373	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451005374	Walker A/P-loop; other site
342451005375	ATP binding site [chemical binding]; other site
342451005376	Q-loop/lid; other site
342451005377	ABC transporter signature motif; other site
342451005378	Walker B; other site
342451005379	D-loop; other site
342451005380	H-loop/switch region; other site
342451005381	TOBE domain; Region: TOBE_2; pfam08402
342451005382	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
342451005383	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451005384	sequence-specific DNA binding site [nucleotide binding]; other site
342451005385	salt bridge; other site
342451005386	Cupin domain; Region: Cupin_2; pfam07883
342451005387	hypothetical protein; Provisional; Region: PRK04387
342451005388	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
342451005389	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
342451005390	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451005391	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
342451005392	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
342451005393	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
342451005394	E3 interaction surface; other site
342451005395	lipoyl attachment site [posttranslational modification]; other site
342451005396	e3 binding domain; Region: E3_binding; pfam02817
342451005397	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
342451005398	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
342451005399	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
342451005400	alpha subunit interface [polypeptide binding]; other site
342451005401	TPP binding site [chemical binding]; other site
342451005402	heterodimer interface [polypeptide binding]; other site
342451005403	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
342451005404	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
342451005405	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
342451005406	TPP-binding site [chemical binding]; other site
342451005407	tetramer interface [polypeptide binding]; other site
342451005408	heterodimer interface [polypeptide binding]; other site
342451005409	phosphorylation loop region [posttranslational modification]
342451005410	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
342451005411	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
342451005412	active site
342451005413	catalytic residues [active]
342451005414	metal binding site [ion binding]; metal-binding site
342451005415	hypothetical protein; Provisional; Region: PRK13667
342451005416	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
342451005417	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
342451005418	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
342451005419	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
342451005420	TrkA-N domain; Region: TrkA_N; pfam02254
342451005421	TrkA-C domain; Region: TrkA_C; pfam02080
342451005422	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
342451005423	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
342451005424	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
342451005425	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
342451005426	catalytic residues [active]
342451005427	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
342451005428	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
342451005429	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
342451005430	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
342451005431	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
342451005432	dimerization domain swap beta strand [polypeptide binding]; other site
342451005433	regulatory protein interface [polypeptide binding]; other site
342451005434	active site
342451005435	regulatory phosphorylation site [posttranslational modification]; other site
342451005436	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
342451005437	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
342451005438	putative RNA binding site [nucleotide binding]; other site
342451005439	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
342451005440	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
342451005441	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
342451005442	Walker A/P-loop; other site
342451005443	ATP binding site [chemical binding]; other site
342451005444	Q-loop/lid; other site
342451005445	ABC transporter signature motif; other site
342451005446	Walker B; other site
342451005447	D-loop; other site
342451005448	H-loop/switch region; other site
342451005449	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
342451005450	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
342451005451	Walker A/P-loop; other site
342451005452	ATP binding site [chemical binding]; other site
342451005453	Q-loop/lid; other site
342451005454	ABC transporter signature motif; other site
342451005455	Walker B; other site
342451005456	D-loop; other site
342451005457	H-loop/switch region; other site
342451005458	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
342451005459	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
342451005460	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
342451005461	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
342451005462	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
342451005463	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
342451005464	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
342451005465	purine monophosphate binding site [chemical binding]; other site
342451005466	dimer interface [polypeptide binding]; other site
342451005467	putative catalytic residues [active]
342451005468	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
342451005469	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
342451005470	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
342451005471	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
342451005472	active site
342451005473	substrate binding site [chemical binding]; other site
342451005474	cosubstrate binding site; other site
342451005475	catalytic site [active]
342451005476	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
342451005477	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
342451005478	dimerization interface [polypeptide binding]; other site
342451005479	putative ATP binding site [chemical binding]; other site
342451005480	amidophosphoribosyltransferase; Provisional; Region: PRK07272
342451005481	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
342451005482	active site
342451005483	tetramer interface [polypeptide binding]; other site
342451005484	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451005485	active site
342451005486	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
342451005487	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
342451005488	dimerization interface [polypeptide binding]; other site
342451005489	ATP binding site [chemical binding]; other site
342451005490	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
342451005491	dimerization interface [polypeptide binding]; other site
342451005492	ATP binding site [chemical binding]; other site
342451005493	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
342451005494	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
342451005495	putative active site [active]
342451005496	catalytic triad [active]
342451005497	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
342451005498	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
342451005499	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
342451005500	ATP binding site [chemical binding]; other site
342451005501	active site
342451005502	substrate binding site [chemical binding]; other site
342451005503	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
342451005504	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
342451005505	NAD binding site [chemical binding]; other site
342451005506	ATP-grasp domain; Region: ATP-grasp; pfam02222
342451005507	AIR carboxylase; Region: AIRC; pfam00731
342451005508	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
342451005509	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
342451005510	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
342451005511	homodimer interface [polypeptide binding]; other site
342451005512	NADP binding site [chemical binding]; other site
342451005513	substrate binding site [chemical binding]; other site
342451005514	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
342451005515	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
342451005516	heme-binding site [chemical binding]; other site
342451005517	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
342451005518	FAD binding pocket [chemical binding]; other site
342451005519	FAD binding motif [chemical binding]; other site
342451005520	phosphate binding motif [ion binding]; other site
342451005521	beta-alpha-beta structure motif; other site
342451005522	NAD binding pocket [chemical binding]; other site
342451005523	Heme binding  pocket [chemical binding]; other site
342451005524	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
342451005525	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
342451005526	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
342451005527	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
342451005528	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
342451005529	D-pathway; other site
342451005530	Putative ubiquinol binding site [chemical binding]; other site
342451005531	Low-spin heme (heme b) binding site [chemical binding]; other site
342451005532	Putative water exit pathway; other site
342451005533	Binuclear center (heme o3/CuB) [ion binding]; other site
342451005534	K-pathway; other site
342451005535	Putative proton exit pathway; other site
342451005536	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
342451005537	Subunit I/III interface [polypeptide binding]; other site
342451005538	Subunit III/IV interface [polypeptide binding]; other site
342451005539	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
342451005540	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
342451005541	active site
342451005542	tetramer interface [polypeptide binding]; other site
342451005543	Beta-lactamase; Region: Beta-lactamase; pfam00144
342451005544	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
342451005545	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
342451005546	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
342451005547	active site
342451005548	substrate binding site [chemical binding]; other site
342451005549	metal binding site [ion binding]; metal-binding site
342451005550	Transcriptional regulator [Transcription]; Region: LytR; COG1316
342451005551	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
342451005552	Autoinducer synthetase; Region: Autoind_synth; cl17404
342451005553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451005554	Coenzyme A binding pocket [chemical binding]; other site
342451005555	Protein of unknown function (DUF2457); Region: DUF2457; pfam10446
342451005556	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
342451005557	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
342451005558	amidase catalytic site [active]
342451005559	Zn binding residues [ion binding]; other site
342451005560	substrate binding site [chemical binding]; other site
342451005561	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
342451005562	Lysozyme subfamily 2; Region: LYZ2; smart00047
342451005563	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451005564	MarR family; Region: MarR; pfam01047
342451005565	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
342451005566	Acyltransferase family; Region: Acyl_transf_3; pfam01757
342451005567	aminotransferase A; Validated; Region: PRK07683
342451005568	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342451005569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451005570	homodimer interface [polypeptide binding]; other site
342451005571	catalytic residue [active]
342451005572	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451005573	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
342451005574	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
342451005575	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
342451005576	substrate binding site [chemical binding]; other site
342451005577	oxyanion hole (OAH) forming residues; other site
342451005578	trimer interface [polypeptide binding]; other site
342451005579	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
342451005580	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
342451005581	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
342451005582	dimer interface [polypeptide binding]; other site
342451005583	tetramer interface [polypeptide binding]; other site
342451005584	PYR/PP interface [polypeptide binding]; other site
342451005585	TPP binding site [chemical binding]; other site
342451005586	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
342451005587	TPP-binding site; other site
342451005588	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
342451005589	isochorismate synthases; Region: isochor_syn; TIGR00543
342451005590	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
342451005591	UbiA prenyltransferase family; Region: UbiA; pfam01040
342451005592	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
342451005593	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451005594	Coenzyme A binding pocket [chemical binding]; other site
342451005595	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
342451005596	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
342451005597	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
342451005598	ComK protein; Region: ComK; pfam06338
342451005599	A short protein domain of unknown function; Region: IDEAL; smart00914
342451005600	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
342451005601	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
342451005602	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
342451005603	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556
342451005604	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
342451005605	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
342451005606	active site
342451005607	metal binding site [ion binding]; metal-binding site
342451005608	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
342451005609	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
342451005610	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
342451005611	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
342451005612	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
342451005613	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
342451005614	protein binding site [polypeptide binding]; other site
342451005615	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
342451005616	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
342451005617	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
342451005618	G1 box; other site
342451005619	putative GEF interaction site [polypeptide binding]; other site
342451005620	GTP/Mg2+ binding site [chemical binding]; other site
342451005621	Switch I region; other site
342451005622	G2 box; other site
342451005623	G3 box; other site
342451005624	Switch II region; other site
342451005625	G4 box; other site
342451005626	G5 box; other site
342451005627	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
342451005628	YueH-like protein; Region: YueH; pfam14166
342451005629	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
342451005630	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
342451005631	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342451005632	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
342451005633	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
342451005634	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
342451005635	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342451005636	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451005637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451005638	putative substrate translocation pore; other site
342451005639	hypothetical protein; Provisional; Region: PRK13679
342451005640	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
342451005641	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
342451005642	Putative esterase; Region: Esterase; pfam00756
342451005643	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
342451005644	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
342451005645	Domain of unknown function DUF20; Region: UPF0118; pfam01594
342451005646	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
342451005647	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
342451005648	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
342451005649	NAD binding site [chemical binding]; other site
342451005650	homotetramer interface [polypeptide binding]; other site
342451005651	homodimer interface [polypeptide binding]; other site
342451005652	substrate binding site [chemical binding]; other site
342451005653	active site
342451005654	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
342451005655	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
342451005656	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
342451005657	TrkA-N domain; Region: TrkA_N; pfam02254
342451005658	TrkA-C domain; Region: TrkA_C; pfam02080
342451005659	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
342451005660	MgtE intracellular N domain; Region: MgtE_N; smart00924
342451005661	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
342451005662	Divalent cation transporter; Region: MgtE; pfam01769
342451005663	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
342451005664	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
342451005665	active site
342451005666	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
342451005667	ATP-NAD kinase; Region: NAD_kinase; pfam01513
342451005668	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
342451005669	synthetase active site [active]
342451005670	NTP binding site [chemical binding]; other site
342451005671	metal binding site [ion binding]; metal-binding site
342451005672	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
342451005673	putative active site [active]
342451005674	putative metal binding residues [ion binding]; other site
342451005675	signature motif; other site
342451005676	putative triphosphate binding site [ion binding]; other site
342451005677	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
342451005678	apolar tunnel; other site
342451005679	heme binding site [chemical binding]; other site
342451005680	dimerization interface [polypeptide binding]; other site
342451005681	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
342451005682	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
342451005683	catalytic residues [active]
342451005684	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
342451005685	NADH(P)-binding; Region: NAD_binding_10; pfam13460
342451005686	NAD binding site [chemical binding]; other site
342451005687	substrate binding site [chemical binding]; other site
342451005688	putative active site [active]
342451005689	oligoendopeptidase F; Region: pepF; TIGR00181
342451005690	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
342451005691	active site
342451005692	Zn binding site [ion binding]; other site
342451005693	Competence protein CoiA-like family; Region: CoiA; cl11541
342451005694	adaptor protein; Provisional; Region: PRK02315
342451005695	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
342451005696	ArsC family; Region: ArsC; pfam03960
342451005697	putative catalytic residues [active]
342451005698	thiol/disulfide switch; other site
342451005699	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
342451005700	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
342451005701	active site
342451005702	HIGH motif; other site
342451005703	dimer interface [polypeptide binding]; other site
342451005704	KMSKS motif; other site
342451005705	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
342451005706	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
342451005707	peptide binding site [polypeptide binding]; other site
342451005708	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
342451005709	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
342451005710	Walker A/P-loop; other site
342451005711	ATP binding site [chemical binding]; other site
342451005712	Q-loop/lid; other site
342451005713	ABC transporter signature motif; other site
342451005714	Walker B; other site
342451005715	D-loop; other site
342451005716	H-loop/switch region; other site
342451005717	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
342451005718	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
342451005719	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
342451005720	Walker A/P-loop; other site
342451005721	ATP binding site [chemical binding]; other site
342451005722	Q-loop/lid; other site
342451005723	ABC transporter signature motif; other site
342451005724	Walker B; other site
342451005725	D-loop; other site
342451005726	H-loop/switch region; other site
342451005727	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
342451005728	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
342451005729	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
342451005730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451005731	dimer interface [polypeptide binding]; other site
342451005732	conserved gate region; other site
342451005733	putative PBP binding loops; other site
342451005734	ABC-ATPase subunit interface; other site
342451005735	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
342451005736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451005737	dimer interface [polypeptide binding]; other site
342451005738	conserved gate region; other site
342451005739	putative PBP binding loops; other site
342451005740	ABC-ATPase subunit interface; other site
342451005741	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
342451005742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451005743	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451005744	putative substrate translocation pore; other site
342451005745	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
342451005746	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
342451005747	dimer interface [polypeptide binding]; other site
342451005748	active site
342451005749	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
342451005750	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
342451005751	dimer interface [polypeptide binding]; other site
342451005752	active site
342451005753	CoA binding pocket [chemical binding]; other site
342451005754	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
342451005755	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
342451005756	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451005757	Walker A motif; other site
342451005758	ATP binding site [chemical binding]; other site
342451005759	Walker B motif; other site
342451005760	arginine finger; other site
342451005761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451005762	Walker A motif; other site
342451005763	ATP binding site [chemical binding]; other site
342451005764	Walker B motif; other site
342451005765	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
342451005766	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
342451005767	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
342451005768	catalytic triad [active]
342451005769	catalytic triad [active]
342451005770	oxyanion hole [active]
342451005771	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
342451005772	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
342451005773	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451005774	active site
342451005775	motif I; other site
342451005776	motif II; other site
342451005777	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451005778	coenzyme A disulfide reductase; Provisional; Region: PRK13512
342451005779	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451005780	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
342451005781	hypothetical protein; Provisional; Region: PRK13673
342451005782	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
342451005783	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
342451005784	Predicted membrane protein [Function unknown]; Region: COG2311
342451005785	Protein of unknown function (DUF418); Region: DUF418; cl12135
342451005786	Protein of unknown function (DUF418); Region: DUF418; pfam04235
342451005787	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
342451005788	Family description; Region: UvrD_C_2; pfam13538
342451005789	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
342451005790	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
342451005791	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
342451005792	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
342451005793	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
342451005794	Catalytic site [active]
342451005795	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
342451005796	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
342451005797	Catalytic site [active]
342451005798	Uncharacterized conserved protein [Function unknown]; Region: COG0398
342451005799	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
342451005800	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
342451005801	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
342451005802	active site
342451005803	dimer interface [polypeptide binding]; other site
342451005804	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
342451005805	dimer interface [polypeptide binding]; other site
342451005806	active site
342451005807	argininosuccinate synthase; Provisional; Region: PRK13820
342451005808	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
342451005809	ANP binding site [chemical binding]; other site
342451005810	Substrate Binding Site II [chemical binding]; other site
342451005811	Substrate Binding Site I [chemical binding]; other site
342451005812	argininosuccinate lyase; Provisional; Region: PRK00855
342451005813	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
342451005814	active sites [active]
342451005815	tetramer interface [polypeptide binding]; other site
342451005816	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
342451005817	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
342451005818	active site
342451005819	catalytic site [active]
342451005820	metal binding site [ion binding]; metal-binding site
342451005821	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
342451005822	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
342451005823	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
342451005824	NAD(P) binding site [chemical binding]; other site
342451005825	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
342451005826	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
342451005827	inhibitor-cofactor binding pocket; inhibition site
342451005828	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451005829	catalytic residue [active]
342451005830	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
342451005831	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
342451005832	putative active site [active]
342451005833	putative FMN binding site [chemical binding]; other site
342451005834	putative substrate binding site [chemical binding]; other site
342451005835	putative catalytic residue [active]
342451005836	general stress protein 13; Validated; Region: PRK08059
342451005837	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
342451005838	RNA binding site [nucleotide binding]; other site
342451005839	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
342451005840	active site
342451005841	Kinase associated protein B; Region: KapB; pfam08810
342451005842	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
342451005843	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
342451005844	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
342451005845	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
342451005846	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
342451005847	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
342451005848	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
342451005849	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
342451005850	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
342451005851	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
342451005852	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
342451005853	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
342451005854	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
342451005855	CoenzymeA binding site [chemical binding]; other site
342451005856	subunit interaction site [polypeptide binding]; other site
342451005857	PHB binding site; other site
342451005858	Predicted permease [General function prediction only]; Region: COG2056
342451005859	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
342451005860	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
342451005861	multifunctional aminopeptidase A; Provisional; Region: PRK00913
342451005862	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
342451005863	interface (dimer of trimers) [polypeptide binding]; other site
342451005864	Substrate-binding/catalytic site; other site
342451005865	Zn-binding sites [ion binding]; other site
342451005866	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
342451005867	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451005868	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
342451005869	hypothetical protein; Provisional; Region: PRK13669
342451005870	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
342451005871	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451005872	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
342451005873	Protein of unknown function (DUF1462); Region: DUF1462; pfam07315
342451005874	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
342451005875	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
342451005876	DltD N-terminal region; Region: DltD_N; pfam04915
342451005877	DltD central region; Region: DltD_M; pfam04918
342451005878	DltD C-terminal region; Region: DltD_C; pfam04914
342451005879	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
342451005880	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
342451005881	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
342451005882	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
342451005883	acyl-activating enzyme (AAE) consensus motif; other site
342451005884	AMP binding site [chemical binding]; other site
342451005885	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
342451005886	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
342451005887	dimerization interface [polypeptide binding]; other site
342451005888	ligand binding site [chemical binding]; other site
342451005889	NADP binding site [chemical binding]; other site
342451005890	catalytic site [active]
342451005891	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
342451005892	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451005893	active site
342451005894	motif I; other site
342451005895	motif II; other site
342451005896	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451005897	Uncharacterized conserved protein [Function unknown]; Region: COG2445
342451005898	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
342451005899	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
342451005900	lipoyl synthase; Provisional; Region: PRK05481
342451005901	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
342451005902	FeS/SAM binding site; other site
342451005903	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
342451005904	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
342451005905	active site
342451005906	metal binding site [ion binding]; metal-binding site
342451005907	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
342451005908	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
342451005909	Uncharacterized conserved protein [Function unknown]; Region: COG1801
342451005910	Nitronate monooxygenase; Region: NMO; pfam03060
342451005911	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
342451005912	FMN binding site [chemical binding]; other site
342451005913	substrate binding site [chemical binding]; other site
342451005914	putative catalytic residue [active]
342451005915	Domain of unknown function DUF21; Region: DUF21; pfam01595
342451005916	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
342451005917	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
342451005918	FeS assembly protein SufB; Region: sufB; TIGR01980
342451005919	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
342451005920	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
342451005921	trimerization site [polypeptide binding]; other site
342451005922	active site
342451005923	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
342451005924	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
342451005925	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342451005926	catalytic residue [active]
342451005927	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
342451005928	FeS assembly protein SufD; Region: sufD; TIGR01981
342451005929	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
342451005930	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
342451005931	Walker A/P-loop; other site
342451005932	ATP binding site [chemical binding]; other site
342451005933	Q-loop/lid; other site
342451005934	ABC transporter signature motif; other site
342451005935	Walker B; other site
342451005936	D-loop; other site
342451005937	H-loop/switch region; other site
342451005938	Predicted membrane protein [Function unknown]; Region: COG2035
342451005939	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
342451005940	Domain of unknown function DUF21; Region: DUF21; pfam01595
342451005941	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
342451005942	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
342451005943	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
342451005944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451005945	dimer interface [polypeptide binding]; other site
342451005946	conserved gate region; other site
342451005947	ABC-ATPase subunit interface; other site
342451005948	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
342451005949	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
342451005950	Walker A/P-loop; other site
342451005951	ATP binding site [chemical binding]; other site
342451005952	Q-loop/lid; other site
342451005953	ABC transporter signature motif; other site
342451005954	Walker B; other site
342451005955	D-loop; other site
342451005956	H-loop/switch region; other site
342451005957	NIL domain; Region: NIL; pfam09383
342451005958	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
342451005959	catalytic residues [active]
342451005960	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
342451005961	putative active site [active]
342451005962	putative metal binding site [ion binding]; other site
342451005963	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
342451005964	lipoyl attachment site [posttranslational modification]; other site
342451005965	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
342451005966	ArsC family; Region: ArsC; pfam03960
342451005967	putative ArsC-like catalytic residues; other site
342451005968	putative TRX-like catalytic residues [active]
342451005969	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
342451005970	catalytic residues [active]
342451005971	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
342451005972	putative FMN binding site [chemical binding]; other site
342451005973	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
342451005974	active site
342451005975	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
342451005976	catalytic residue [active]
342451005977	dimer interface [polypeptide binding]; other site
342451005978	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
342451005979	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
342451005980	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
342451005981	Citrate transporter; Region: CitMHS; pfam03600
342451005982	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
342451005983	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
342451005984	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
342451005985	Sodium Bile acid symporter family; Region: SBF; cl17470
342451005986	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
342451005987	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
342451005988	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
342451005989	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451005990	non-specific DNA binding site [nucleotide binding]; other site
342451005991	salt bridge; other site
342451005992	sequence-specific DNA binding site [nucleotide binding]; other site
342451005993	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
342451005994	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
342451005995	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
342451005996	MepB protein; Region: MepB; pfam08877
342451005997	CsbD-like; Region: CsbD; pfam05532
342451005998	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
342451005999	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
342451006000	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
342451006001	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
342451006002	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
342451006003	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
342451006004	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451006005	motif II; other site
342451006006	DinB superfamily; Region: DinB_2; pfam12867
342451006007	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
342451006008	SmpB-tmRNA interface; other site
342451006009	ribonuclease R; Region: RNase_R; TIGR02063
342451006010	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
342451006011	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
342451006012	RNB domain; Region: RNB; pfam00773
342451006013	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
342451006014	RNA binding site [nucleotide binding]; other site
342451006015	Esterase/lipase [General function prediction only]; Region: COG1647
342451006016	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
342451006017	enolase; Provisional; Region: eno; PRK00077
342451006018	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
342451006019	dimer interface [polypeptide binding]; other site
342451006020	metal binding site [ion binding]; metal-binding site
342451006021	substrate binding pocket [chemical binding]; other site
342451006022	phosphoglyceromutase; Provisional; Region: PRK05434
342451006023	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
342451006024	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
342451006025	triosephosphate isomerase; Provisional; Region: PRK14565
342451006026	substrate binding site [chemical binding]; other site
342451006027	dimer interface [polypeptide binding]; other site
342451006028	catalytic triad [active]
342451006029	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
342451006030	Phosphoglycerate kinase; Region: PGK; pfam00162
342451006031	substrate binding site [chemical binding]; other site
342451006032	hinge regions; other site
342451006033	ADP binding site [chemical binding]; other site
342451006034	catalytic site [active]
342451006035	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
342451006036	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
342451006037	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
342451006038	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
342451006039	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
342451006040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451006041	TIGR01777 family protein; Region: yfcH
342451006042	NAD(P) binding site [chemical binding]; other site
342451006043	active site
342451006044	Clp protease; Region: CLP_protease; pfam00574
342451006045	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
342451006046	oligomer interface [polypeptide binding]; other site
342451006047	active site residues [active]
342451006048	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
342451006049	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
342451006050	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
342451006051	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342451006052	active site
342451006053	metal binding site [ion binding]; metal-binding site
342451006054	YolD-like protein; Region: YolD; pfam08863
342451006055	Coat F domain; Region: Coat_F; cl17715
342451006056	Phage terminase, small subunit; Region: Terminase_4; pfam05119
342451006057	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
342451006058	Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731
342451006059	Uncharacterized conserved protein [Function unknown]; Region: COG4983
342451006060	Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943
342451006061	D5 N terminal like; Region: D5_N; smart00885
342451006062	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
342451006063	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
342451006064	Domain of unknown function (DUF771); Region: DUF771; pfam05595
342451006065	Prophage antirepressor [Transcription]; Region: COG3617
342451006066	BRO family, N-terminal domain; Region: Bro-N; smart01040
342451006067	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451006068	non-specific DNA binding site [nucleotide binding]; other site
342451006069	salt bridge; other site
342451006070	sequence-specific DNA binding site [nucleotide binding]; other site
342451006071	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451006072	non-specific DNA binding site [nucleotide binding]; other site
342451006073	salt bridge; other site
342451006074	sequence-specific DNA binding site [nucleotide binding]; other site
342451006075	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
342451006076	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
342451006077	Int/Topo IB signature motif; other site
342451006078	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
342451006079	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
342451006080	Uncharacterized conserved protein [Function unknown]; Region: COG1284
342451006081	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
342451006082	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
342451006083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
342451006084	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
342451006085	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
342451006086	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
342451006087	phosphate binding site [ion binding]; other site
342451006088	putative substrate binding pocket [chemical binding]; other site
342451006089	dimer interface [polypeptide binding]; other site
342451006090	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
342451006091	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
342451006092	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
342451006093	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451006094	TPR repeat; Region: TPR_11; pfam13414
342451006095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
342451006096	binding surface
342451006097	TPR motif; other site
342451006098	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
342451006099	binding surface
342451006100	TPR motif; other site
342451006101	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
342451006102	trimer interface [polypeptide binding]; other site
342451006103	active site
342451006104	substrate binding site [chemical binding]; other site
342451006105	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
342451006106	CoA binding site [chemical binding]; other site
342451006107	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
342451006108	HPr kinase/phosphorylase; Provisional; Region: PRK05428
342451006109	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
342451006110	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
342451006111	Hpr binding site; other site
342451006112	active site
342451006113	homohexamer subunit interaction site [polypeptide binding]; other site
342451006114	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
342451006115	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
342451006116	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
342451006117	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
342451006118	excinuclease ABC subunit B; Provisional; Region: PRK05298
342451006119	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342451006120	ATP binding site [chemical binding]; other site
342451006121	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342451006122	nucleotide binding region [chemical binding]; other site
342451006123	ATP-binding site [chemical binding]; other site
342451006124	Ultra-violet resistance protein B; Region: UvrB; pfam12344
342451006125	UvrB/uvrC motif; Region: UVR; pfam02151
342451006126	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
342451006127	Zn2+ binding site [ion binding]; other site
342451006128	Mg2+ binding site [ion binding]; other site
342451006129	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
342451006130	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451006131	Surface antigen [General function prediction only]; Region: COG3942
342451006132	CHAP domain; Region: CHAP; pfam05257
342451006133	peptide chain release factor 2; Provisional; Region: PRK06746
342451006134	PCRF domain; Region: PCRF; pfam03462
342451006135	RF-1 domain; Region: RF-1; pfam00472
342451006136	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
342451006137	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
342451006138	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
342451006139	nucleotide binding region [chemical binding]; other site
342451006140	ATP-binding site [chemical binding]; other site
342451006141	SEC-C motif; Region: SEC-C; pfam02810
342451006142	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
342451006143	30S subunit binding site; other site
342451006144	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
342451006145	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451006146	active site
342451006147	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342451006148	putative Mg++ binding site [ion binding]; other site
342451006149	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342451006150	nucleotide binding region [chemical binding]; other site
342451006151	ATP-binding site [chemical binding]; other site
342451006152	EDD domain protein, DegV family; Region: DegV; TIGR00762
342451006153	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
342451006154	Uncharacterized conserved protein [Function unknown]; Region: COG1739
342451006155	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
342451006156	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
342451006157	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
342451006158	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
342451006159	Mg++ binding site [ion binding]; other site
342451006160	putative catalytic motif [active]
342451006161	substrate binding site [chemical binding]; other site
342451006162	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
342451006163	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
342451006164	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342451006165	metal binding site [ion binding]; metal-binding site
342451006166	active site
342451006167	I-site; other site
342451006168	Uncharacterized conserved protein [Function unknown]; Region: COG2966
342451006169	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
342451006170	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
342451006171	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
342451006172	peptidase T; Region: peptidase-T; TIGR01882
342451006173	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
342451006174	metal binding site [ion binding]; metal-binding site
342451006175	dimer interface [polypeptide binding]; other site
342451006176	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
342451006177	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
342451006178	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
342451006179	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
342451006180	FAD binding domain; Region: FAD_binding_4; pfam01565
342451006181	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
342451006182	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
342451006183	CHY zinc finger; Region: zf-CHY; pfam05495
342451006184	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
342451006185	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
342451006186	putative ligand binding residues [chemical binding]; other site
342451006187	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
342451006188	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
342451006189	Walker A/P-loop; other site
342451006190	ATP binding site [chemical binding]; other site
342451006191	Q-loop/lid; other site
342451006192	ABC transporter signature motif; other site
342451006193	Walker B; other site
342451006194	D-loop; other site
342451006195	H-loop/switch region; other site
342451006196	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
342451006197	ABC-ATPase subunit  interface; other site
342451006198	dimer interface [polypeptide binding]; other site
342451006199	putative PBP binding regions; other site
342451006200	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
342451006201	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
342451006202	ABC-ATPase subunit  interface; other site
342451006203	dimer interface [polypeptide binding]; other site
342451006204	putative PBP binding regions; other site
342451006205	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
342451006206	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
342451006207	dimer interface [polypeptide binding]; other site
342451006208	putative radical transfer pathway; other site
342451006209	diiron center [ion binding]; other site
342451006210	tyrosyl radical; other site
342451006211	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
342451006212	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
342451006213	Class I ribonucleotide reductase; Region: RNR_I; cd01679
342451006214	active site
342451006215	dimer interface [polypeptide binding]; other site
342451006216	catalytic residues [active]
342451006217	effector binding site; other site
342451006218	R2 peptide binding site; other site
342451006219	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
342451006220	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
342451006221	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
342451006222	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
342451006223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451006224	putative substrate translocation pore; other site
342451006225	POT family; Region: PTR2; cl17359
342451006226	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
342451006227	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451006228	putative substrate translocation pore; other site
342451006229	POT family; Region: PTR2; cl17359
342451006230	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
342451006231	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
342451006232	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
342451006233	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
342451006234	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342451006235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451006236	homodimer interface [polypeptide binding]; other site
342451006237	catalytic residue [active]
342451006238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
342451006239	dimer interface [polypeptide binding]; other site
342451006240	conserved gate region; other site
342451006241	ABC-ATPase subunit interface; other site
342451006242	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
342451006243	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
342451006244	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
342451006245	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
342451006246	Walker A/P-loop; other site
342451006247	ATP binding site [chemical binding]; other site
342451006248	Q-loop/lid; other site
342451006249	ABC transporter signature motif; other site
342451006250	Walker B; other site
342451006251	D-loop; other site
342451006252	H-loop/switch region; other site
342451006253	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
342451006254	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342451006255	ATP binding site [chemical binding]; other site
342451006256	putative Mg++ binding site [ion binding]; other site
342451006257	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342451006258	nucleotide binding region [chemical binding]; other site
342451006259	ATP-binding site [chemical binding]; other site
342451006260	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
342451006261	HRDC domain; Region: HRDC; pfam00570
342451006262	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
342451006263	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451006264	Walker A/P-loop; other site
342451006265	ATP binding site [chemical binding]; other site
342451006266	Q-loop/lid; other site
342451006267	ABC transporter signature motif; other site
342451006268	Walker B; other site
342451006269	D-loop; other site
342451006270	H-loop/switch region; other site
342451006271	ABC transporter; Region: ABC_tran_2; pfam12848
342451006272	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
342451006273	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
342451006274	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
342451006275	Sulfatase; Region: Sulfatase; pfam00884
342451006276	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
342451006277	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
342451006278	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
342451006279	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
342451006280	substrate-cofactor binding pocket; other site
342451006281	homodimer interface [polypeptide binding]; other site
342451006282	Aminotransferase class IV; Region: Aminotran_4; pfam01063
342451006283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451006284	catalytic residue [active]
342451006285	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
342451006286	chorismate binding enzyme; Region: Chorismate_bind; cl10555
342451006287	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
342451006288	Glutamine amidotransferase class-I; Region: GATase; pfam00117
342451006289	glutamine binding [chemical binding]; other site
342451006290	catalytic triad [active]
342451006291	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
342451006292	Ligand Binding Site [chemical binding]; other site
342451006293	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
342451006294	active site
342451006295	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
342451006296	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
342451006297	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
342451006298	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
342451006299	Ligand binding site; other site
342451006300	Putative Catalytic site; other site
342451006301	DXD motif; other site
342451006302	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
342451006303	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342451006304	active site
342451006305	catalytic tetrad [active]
342451006306	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
342451006307	Domain of unknown function DUF21; Region: DUF21; pfam01595
342451006308	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
342451006309	Transporter associated domain; Region: CorC_HlyC; smart01091
342451006310	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
342451006311	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
342451006312	active site
342451006313	dimer interface [polypeptide binding]; other site
342451006314	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
342451006315	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
342451006316	active site
342451006317	phosphorylation site [posttranslational modification]
342451006318	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
342451006319	active site
342451006320	P-loop; other site
342451006321	phosphorylation site [posttranslational modification]
342451006322	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
342451006323	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
342451006324	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
342451006325	putative substrate binding site [chemical binding]; other site
342451006326	putative ATP binding site [chemical binding]; other site
342451006327	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
342451006328	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
342451006329	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
342451006330	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
342451006331	putative deacylase active site [active]
342451006332	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
342451006333	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
342451006334	active site
342451006335	tetramer interface; other site
342451006336	D-galactonate transporter; Region: 2A0114; TIGR00893
342451006337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451006338	putative substrate translocation pore; other site
342451006339	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
342451006340	trimer interface [polypeptide binding]; other site
342451006341	putative Zn binding site [ion binding]; other site
342451006342	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
342451006343	malate dehydrogenase; Reviewed; Region: PRK06223
342451006344	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
342451006345	NAD(P) binding site [chemical binding]; other site
342451006346	dimer interface [polypeptide binding]; other site
342451006347	tetramer (dimer of dimers) interface [polypeptide binding]; other site
342451006348	substrate binding site [chemical binding]; other site
342451006349	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
342451006350	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
342451006351	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
342451006352	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342451006353	active site
342451006354	catalytic tetrad [active]
342451006355	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
342451006356	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
342451006357	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
342451006358	Transcriptional regulators [Transcription]; Region: MarR; COG1846
342451006359	MarR family; Region: MarR; pfam01047
342451006360	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
342451006361	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
342451006362	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
342451006363	Walker A/P-loop; other site
342451006364	ATP binding site [chemical binding]; other site
342451006365	Q-loop/lid; other site
342451006366	ABC transporter signature motif; other site
342451006367	Walker B; other site
342451006368	D-loop; other site
342451006369	H-loop/switch region; other site
342451006370	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
342451006371	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
342451006372	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
342451006373	Walker A/P-loop; other site
342451006374	ATP binding site [chemical binding]; other site
342451006375	Q-loop/lid; other site
342451006376	ABC transporter signature motif; other site
342451006377	Walker B; other site
342451006378	D-loop; other site
342451006379	H-loop/switch region; other site
342451006380	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
342451006381	hypothetical protein; Validated; Region: PRK00124
342451006382	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
342451006383	Lysine efflux permease [General function prediction only]; Region: COG1279
342451006384	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
342451006385	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342451006386	DNA-binding site [nucleotide binding]; DNA binding site
342451006387	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342451006388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451006389	homodimer interface [polypeptide binding]; other site
342451006390	catalytic residue [active]
342451006391	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
342451006392	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
342451006393	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
342451006394	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451006395	Coenzyme A binding pocket [chemical binding]; other site
342451006396	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
342451006397	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
342451006398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451006399	putative substrate translocation pore; other site
342451006400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
342451006401	sugar efflux transporter; Region: 2A0120; TIGR00899
342451006402	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451006403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451006404	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
342451006405	dimerization interface [polypeptide binding]; other site
342451006406	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
342451006407	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
342451006408	substrate binding site [chemical binding]; other site
342451006409	THF binding site; other site
342451006410	zinc-binding site [ion binding]; other site
342451006411	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
342451006412	hypothetical protein; Provisional; Region: PRK12378
342451006413	MarR family; Region: MarR_2; cl17246
342451006414	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342451006415	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
342451006416	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
342451006417	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
342451006418	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451006419	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
342451006420	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451006421	Surface antigen [General function prediction only]; Region: COG3942
342451006422	CHAP domain; Region: CHAP; pfam05257
342451006423	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
342451006424	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
342451006425	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342451006426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
342451006427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342451006428	ATP binding site [chemical binding]; other site
342451006429	Mg2+ binding site [ion binding]; other site
342451006430	G-X-G motif; other site
342451006431	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342451006432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
342451006433	active site
342451006434	phosphorylation site [posttranslational modification]
342451006435	intermolecular recognition site; other site
342451006436	dimerization interface [polypeptide binding]; other site
342451006437	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
342451006438	DNA binding site [nucleotide binding]
342451006439	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
342451006440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451006441	NAD(P) binding site [chemical binding]; other site
342451006442	active site
342451006443	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451006444	Coenzyme A binding pocket [chemical binding]; other site
342451006445	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
342451006446	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
342451006447	Uncharacterized membrane protein [Function unknown]; Region: COG3949
342451006448	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
342451006449	Na binding site [ion binding]; other site
342451006450	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
342451006451	DAK2 domain; Region: Dak2; cl03685
342451006452	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
342451006453	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
342451006454	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
342451006455	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
342451006456	ABC-ATPase subunit  interface; other site
342451006457	dimer interface [polypeptide binding]; other site
342451006458	putative PBP binding regions; other site
342451006459	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
342451006460	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
342451006461	ABC-ATPase subunit  interface; other site
342451006462	dimer interface [polypeptide binding]; other site
342451006463	putative PBP binding regions; other site
342451006464	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
342451006465	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
342451006466	Walker A/P-loop; other site
342451006467	ATP binding site [chemical binding]; other site
342451006468	Q-loop/lid; other site
342451006469	ABC transporter signature motif; other site
342451006470	Walker B; other site
342451006471	D-loop; other site
342451006472	H-loop/switch region; other site
342451006473	Uncharacterized conserved protein [Function unknown]; Region: COG1284
342451006474	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
342451006475	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
342451006476	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
342451006477	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
342451006478	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
342451006479	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
342451006480	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
342451006481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451006482	Walker A/P-loop; other site
342451006483	ATP binding site [chemical binding]; other site
342451006484	Q-loop/lid; other site
342451006485	ABC transporter signature motif; other site
342451006486	Walker B; other site
342451006487	D-loop; other site
342451006488	H-loop/switch region; other site
342451006489	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
342451006490	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
342451006491	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
342451006492	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342451006493	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
342451006494	active site
342451006495	nucleotide binding site [chemical binding]; other site
342451006496	HIGH motif; other site
342451006497	KMSKS motif; other site
342451006498	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
342451006499	active site
342451006500	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
342451006501	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
342451006502	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
342451006503	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
342451006504	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
342451006505	Walker A/P-loop; other site
342451006506	ATP binding site [chemical binding]; other site
342451006507	Q-loop/lid; other site
342451006508	ABC transporter signature motif; other site
342451006509	Walker B; other site
342451006510	D-loop; other site
342451006511	H-loop/switch region; other site
342451006512	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
342451006513	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
342451006514	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
342451006515	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
342451006516	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
342451006517	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
342451006518	FeoA domain; Region: FeoA; pfam04023
342451006519	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
342451006520	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
342451006521	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
342451006522	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
342451006523	dimer interface [polypeptide binding]; other site
342451006524	ABC-ATPase subunit  interface; other site
342451006525	putative PBP binding regions; other site
342451006526	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
342451006527	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
342451006528	intersubunit interface [polypeptide binding]; other site
342451006529	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
342451006530	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
342451006531	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
342451006532	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
342451006533	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
342451006534	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
342451006535	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
342451006536	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
342451006537	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
342451006538	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
342451006539	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
342451006540	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
342451006541	active site
342451006542	DNA binding site [nucleotide binding]
342451006543	Int/Topo IB signature motif; other site
342451006544	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
342451006545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
342451006546	Protein of unknown function, DUF606; Region: DUF606; pfam04657
342451006547	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
342451006548	HlyD family secretion protein; Region: HlyD_3; pfam13437
342451006549	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
342451006550	Transcriptional regulators [Transcription]; Region: MarR; COG1846
342451006551	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
342451006552	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
342451006553	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
342451006554	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
342451006555	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451006556	motif II; other site
342451006557	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
342451006558	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
342451006559	ABC-ATPase subunit  interface; other site
342451006560	dimer interface [polypeptide binding]; other site
342451006561	putative PBP binding regions; other site
342451006562	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
342451006563	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
342451006564	putative binding site residues; other site
342451006565	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
342451006566	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
342451006567	minor groove reading motif; other site
342451006568	helix-hairpin-helix signature motif; other site
342451006569	substrate binding pocket [chemical binding]; other site
342451006570	active site
342451006571	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
342451006572	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
342451006573	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
342451006574	active site
342451006575	HIGH motif; other site
342451006576	KMSK motif region; other site
342451006577	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
342451006578	tRNA binding surface [nucleotide binding]; other site
342451006579	anticodon binding site; other site
342451006580	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
342451006581	YwhD family; Region: YwhD; pfam08741
342451006582	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
342451006583	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
342451006584	Zn2+ binding site [ion binding]; other site
342451006585	Mg2+ binding site [ion binding]; other site
342451006586	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
342451006587	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
342451006588	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451006589	Coenzyme A binding pocket [chemical binding]; other site
342451006590	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
342451006591	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
342451006592	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
342451006593	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342451006594	active site
342451006595	catalytic tetrad [active]
342451006596	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
342451006597	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
342451006598	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
342451006599	diphosphomevalonate decarboxylase; Region: PLN02407
342451006600	mevalonate kinase; Region: mevalon_kin; TIGR00549
342451006601	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
342451006602	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
342451006603	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
342451006604	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
342451006605	putative heme peroxidase; Provisional; Region: PRK12276
342451006606	Uncharacterized conserved protein [Function unknown]; Region: COG2966
342451006607	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
342451006608	Uncharacterized conserved protein [Function unknown]; Region: COG3610
342451006609	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
342451006610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451006611	putative substrate translocation pore; other site
342451006612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451006613	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451006614	MarR family; Region: MarR; pfam01047
342451006615	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
342451006616	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
342451006617	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
342451006618	ligand binding site [chemical binding]; other site
342451006619	active site
342451006620	UGI interface [polypeptide binding]; other site
342451006621	catalytic site [active]
342451006622	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
342451006623	dimer interface [polypeptide binding]; other site
342451006624	substrate binding site [chemical binding]; other site
342451006625	ATP binding site [chemical binding]; other site
342451006626	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
342451006627	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
342451006628	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
342451006629	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
342451006630	MarR family; Region: MarR_2; pfam12802
342451006631	proline/glycine betaine transporter; Provisional; Region: PRK10642
342451006632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451006633	putative substrate translocation pore; other site
342451006634	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
342451006635	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
342451006636	dimer interface [polypeptide binding]; other site
342451006637	active site
342451006638	acyl-CoA synthetase; Validated; Region: PRK07638
342451006639	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
342451006640	acyl-activating enzyme (AAE) consensus motif; other site
342451006641	AMP binding site [chemical binding]; other site
342451006642	active site
342451006643	CoA binding site [chemical binding]; other site
342451006644	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
342451006645	tetramer interface [polypeptide binding]; other site
342451006646	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
342451006647	active site
342451006648	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
342451006649	active site
342451006650	dimer interface [polypeptide binding]; other site
342451006651	magnesium binding site [ion binding]; other site
342451006652	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
342451006653	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
342451006654	active site
342451006655	trimer interface [polypeptide binding]; other site
342451006656	allosteric site; other site
342451006657	active site lid [active]
342451006658	hexamer (dimer of trimers) interface [polypeptide binding]; other site
342451006659	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
342451006660	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
342451006661	putative GTP cyclohydrolase; Provisional; Region: PRK13674
342451006662	MarR family; Region: MarR_2; cl17246
342451006663	Predicted flavoprotein [General function prediction only]; Region: COG0431
342451006664	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
342451006665	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451006666	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
342451006667	active site
342451006668	motif I; other site
342451006669	motif II; other site
342451006670	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451006671	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
342451006672	nucleoside/Zn binding site; other site
342451006673	dimer interface [polypeptide binding]; other site
342451006674	catalytic motif [active]
342451006675	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
342451006676	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
342451006677	Substrate-binding site [chemical binding]; other site
342451006678	Substrate specificity [chemical binding]; other site
342451006679	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
342451006680	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
342451006681	Substrate-binding site [chemical binding]; other site
342451006682	Substrate specificity [chemical binding]; other site
342451006683	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
342451006684	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451006685	motif II; other site
342451006686	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
342451006687	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
342451006688	homodimer interface [polypeptide binding]; other site
342451006689	substrate-cofactor binding pocket; other site
342451006690	catalytic residue [active]
342451006691	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
342451006692	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451006693	NAD(P) binding site [chemical binding]; other site
342451006694	active site
342451006695	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
342451006696	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451006697	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451006698	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
342451006699	dimerization interface [polypeptide binding]; other site
342451006700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451006701	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451006702	putative substrate translocation pore; other site
342451006703	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
342451006704	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
342451006705	PhnA protein; Region: PhnA; pfam03831
342451006706	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
342451006707	putative hydrophobic ligand binding site [chemical binding]; other site
342451006708	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
342451006709	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
342451006710	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
342451006711	S-methylmethionine transporter; Provisional; Region: PRK11387
342451006712	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
342451006713	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
342451006714	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
342451006715	NAD(P) binding site [chemical binding]; other site
342451006716	agmatinase; Region: agmatinase; TIGR01230
342451006717	Agmatinase-like family; Region: Agmatinase-like; cd09990
342451006718	active site
342451006719	oligomer interface [polypeptide binding]; other site
342451006720	Mn binding site [ion binding]; other site
342451006721	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
342451006722	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
342451006723	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
342451006724	putative hydrophobic ligand binding site [chemical binding]; other site
342451006725	ribulokinase; Provisional; Region: PRK04123
342451006726	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
342451006727	N- and C-terminal domain interface [polypeptide binding]; other site
342451006728	active site
342451006729	MgATP binding site [chemical binding]; other site
342451006730	catalytic site [active]
342451006731	metal binding site [ion binding]; metal-binding site
342451006732	carbohydrate binding site [chemical binding]; other site
342451006733	homodimer interface [polypeptide binding]; other site
342451006734	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
342451006735	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
342451006736	NAD(P) binding site [chemical binding]; other site
342451006737	polyol permease family; Region: 2A0118; TIGR00897
342451006738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451006739	putative substrate translocation pore; other site
342451006740	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
342451006741	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
342451006742	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
342451006743	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
342451006744	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
342451006745	Walker B; other site
342451006746	D-loop; other site
342451006747	H-loop/switch region; other site
342451006748	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
342451006749	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
342451006750	active site
342451006751	intersubunit interface [polypeptide binding]; other site
342451006752	catalytic residue [active]
342451006753	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342451006754	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342451006755	DNA binding site [nucleotide binding]
342451006756	domain linker motif; other site
342451006757	Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272
342451006758	putative dimerization interface [polypeptide binding]; other site
342451006759	putative ligand binding site [chemical binding]; other site
342451006760	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451006761	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451006762	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
342451006763	putative dimerization interface [polypeptide binding]; other site
342451006764	beta-lactamase TEM; Provisional; Region: PRK15442
342451006765	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
342451006766	GntP family permease; Region: GntP_permease; pfam02447
342451006767	fructuronate transporter; Provisional; Region: PRK10034; cl15264
342451006768	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
342451006769	active site
342451006770	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342451006771	catalytic tetrad [active]
342451006772	putative monooxygenase; Provisional; Region: PRK11118
342451006773	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
342451006774	Domain of unknown function (DUF303); Region: DUF303; pfam03629
342451006775	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451006776	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
342451006777	NAD(P) binding site [chemical binding]; other site
342451006778	active site
342451006779	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
342451006780	ornithine cyclodeaminase; Validated; Region: PRK08618
342451006781	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
342451006782	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
342451006783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342451006784	NAD(P) binding site [chemical binding]; other site
342451006785	active site
342451006786	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
342451006787	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
342451006788	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
342451006789	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451006790	Coenzyme A binding pocket [chemical binding]; other site
342451006791	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
342451006792	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
342451006793	hypothetical protein; Provisional; Region: PRK06762
342451006794	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
342451006795	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
342451006796	substrate-cofactor binding pocket; other site
342451006797	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451006798	catalytic residue [active]
342451006799	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
342451006800	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
342451006801	metal binding site [ion binding]; metal-binding site
342451006802	dimer interface [polypeptide binding]; other site
342451006803	elongation factor Tu; Reviewed; Region: PRK00049
342451006804	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
342451006805	G1 box; other site
342451006806	GEF interaction site [polypeptide binding]; other site
342451006807	GTP/Mg2+ binding site [chemical binding]; other site
342451006808	Switch I region; other site
342451006809	G2 box; other site
342451006810	G3 box; other site
342451006811	Switch II region; other site
342451006812	G4 box; other site
342451006813	G5 box; other site
342451006814	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
342451006815	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
342451006816	Antibiotic Binding Site [chemical binding]; other site
342451006817	elongation factor G; Reviewed; Region: PRK00007
342451006818	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
342451006819	G1 box; other site
342451006820	putative GEF interaction site [polypeptide binding]; other site
342451006821	GTP/Mg2+ binding site [chemical binding]; other site
342451006822	Switch I region; other site
342451006823	G2 box; other site
342451006824	G3 box; other site
342451006825	Switch II region; other site
342451006826	G4 box; other site
342451006827	G5 box; other site
342451006828	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
342451006829	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
342451006830	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
342451006831	30S ribosomal protein S7; Validated; Region: PRK05302
342451006832	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
342451006833	S17 interaction site [polypeptide binding]; other site
342451006834	S8 interaction site; other site
342451006835	16S rRNA interaction site [nucleotide binding]; other site
342451006836	streptomycin interaction site [chemical binding]; other site
342451006837	23S rRNA interaction site [nucleotide binding]; other site
342451006838	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
342451006839	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
342451006840	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
342451006841	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
342451006842	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
342451006843	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
342451006844	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
342451006845	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
342451006846	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
342451006847	G-loop; other site
342451006848	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
342451006849	DNA binding site [nucleotide binding]
342451006850	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
342451006851	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
342451006852	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
342451006853	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
342451006854	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
342451006855	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
342451006856	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
342451006857	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
342451006858	RPB10 interaction site [polypeptide binding]; other site
342451006859	RPB1 interaction site [polypeptide binding]; other site
342451006860	RPB11 interaction site [polypeptide binding]; other site
342451006861	RPB3 interaction site [polypeptide binding]; other site
342451006862	RPB12 interaction site [polypeptide binding]; other site
342451006863	Methyltransferase domain; Region: Methyltransf_31; pfam13847
342451006864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451006865	S-adenosylmethionine binding site [chemical binding]; other site
342451006866	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
342451006867	peripheral dimer interface [polypeptide binding]; other site
342451006868	core dimer interface [polypeptide binding]; other site
342451006869	L10 interface [polypeptide binding]; other site
342451006870	L11 interface [polypeptide binding]; other site
342451006871	putative EF-Tu interaction site [polypeptide binding]; other site
342451006872	putative EF-G interaction site [polypeptide binding]; other site
342451006873	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
342451006874	23S rRNA interface [nucleotide binding]; other site
342451006875	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
342451006876	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
342451006877	mRNA/rRNA interface [nucleotide binding]; other site
342451006878	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
342451006879	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
342451006880	23S rRNA interface [nucleotide binding]; other site
342451006881	L7/L12 interface [polypeptide binding]; other site
342451006882	putative thiostrepton binding site; other site
342451006883	L25 interface [polypeptide binding]; other site
342451006884	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
342451006885	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
342451006886	putative homodimer interface [polypeptide binding]; other site
342451006887	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
342451006888	heterodimer interface [polypeptide binding]; other site
342451006889	homodimer interface [polypeptide binding]; other site
342451006890	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
342451006891	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
342451006892	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
342451006893	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342451006894	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
342451006895	YacP-like NYN domain; Region: NYN_YacP; cl01491
342451006896	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
342451006897	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
342451006898	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
342451006899	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
342451006900	dimerization interface [polypeptide binding]; other site
342451006901	active site
342451006902	metal binding site [ion binding]; metal-binding site
342451006903	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
342451006904	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
342451006905	active site
342451006906	HIGH motif; other site
342451006907	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
342451006908	KMSKS motif; other site
342451006909	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
342451006910	tRNA binding surface [nucleotide binding]; other site
342451006911	anticodon binding site; other site
342451006912	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
342451006913	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
342451006914	trimer interface [polypeptide binding]; other site
342451006915	active site
342451006916	substrate binding site [chemical binding]; other site
342451006917	CoA binding site [chemical binding]; other site
342451006918	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
342451006919	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
342451006920	active site
342451006921	HIGH motif; other site
342451006922	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
342451006923	active site
342451006924	KMSKS motif; other site
342451006925	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
342451006926	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
342451006927	putative active site [active]
342451006928	DNA repair protein RadA; Provisional; Region: PRK11823
342451006929	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
342451006930	Walker A motif/ATP binding site; other site
342451006931	ATP binding site [chemical binding]; other site
342451006932	Walker B motif; other site
342451006933	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
342451006934	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
342451006935	Clp amino terminal domain; Region: Clp_N; pfam02861
342451006936	Clp amino terminal domain; Region: Clp_N; pfam02861
342451006937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451006938	Walker A motif; other site
342451006939	ATP binding site [chemical binding]; other site
342451006940	Walker B motif; other site
342451006941	arginine finger; other site
342451006942	UvrB/uvrC motif; Region: UVR; pfam02151
342451006943	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451006944	Walker A motif; other site
342451006945	ATP binding site [chemical binding]; other site
342451006946	Walker B motif; other site
342451006947	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
342451006948	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
342451006949	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
342451006950	ADP binding site [chemical binding]; other site
342451006951	phosphagen binding site; other site
342451006952	substrate specificity loop; other site
342451006953	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
342451006954	UvrB/uvrC motif; Region: UVR; pfam02151
342451006955	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
342451006956	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
342451006957	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
342451006958	Nucleoside recognition; Region: Gate; pfam07670
342451006959	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
342451006960	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
342451006961	predicted active site [active]
342451006962	catalytic triad [active]
342451006963	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
342451006964	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
342451006965	active site
342451006966	multimer interface [polypeptide binding]; other site
342451006967	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
342451006968	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342451006969	DNA-binding site [nucleotide binding]; DNA binding site
342451006970	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342451006971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451006972	homodimer interface [polypeptide binding]; other site
342451006973	catalytic residue [active]
342451006974	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
342451006975	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
342451006976	dimer interface [polypeptide binding]; other site
342451006977	putative anticodon binding site; other site
342451006978	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
342451006979	motif 1; other site
342451006980	active site
342451006981	motif 2; other site
342451006982	motif 3; other site
342451006983	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
342451006984	catalytic center binding site [active]
342451006985	ATP binding site [chemical binding]; other site
342451006986	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
342451006987	homooctamer interface [polypeptide binding]; other site
342451006988	active site
342451006989	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
342451006990	dihydropteroate synthase; Region: DHPS; TIGR01496
342451006991	substrate binding pocket [chemical binding]; other site
342451006992	dimer interface [polypeptide binding]; other site
342451006993	inhibitor binding site; inhibition site
342451006994	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
342451006995	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
342451006996	dimer interface [polypeptide binding]; other site
342451006997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451006998	catalytic residue [active]
342451006999	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
342451007000	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
342451007001	dimerization interface [polypeptide binding]; other site
342451007002	domain crossover interface; other site
342451007003	redox-dependent activation switch; other site
342451007004	FtsH Extracellular; Region: FtsH_ext; pfam06480
342451007005	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
342451007006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451007007	Walker A motif; other site
342451007008	ATP binding site [chemical binding]; other site
342451007009	Walker B motif; other site
342451007010	arginine finger; other site
342451007011	Peptidase family M41; Region: Peptidase_M41; pfam01434
342451007012	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451007013	active site
342451007014	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
342451007015	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
342451007016	Ligand Binding Site [chemical binding]; other site
342451007017	TilS substrate C-terminal domain; Region: TilS_C; smart00977
342451007018	hypothetical protein; Provisional; Region: PRK08582
342451007019	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
342451007020	RNA binding site [nucleotide binding]; other site
342451007021	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
342451007022	Septum formation initiator; Region: DivIC; pfam04977
342451007023	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342451007024	RNA binding surface [nucleotide binding]; other site
342451007025	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
342451007026	putative SAM binding site [chemical binding]; other site
342451007027	putative homodimer interface [polypeptide binding]; other site
342451007028	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
342451007029	homodimer interface [polypeptide binding]; other site
342451007030	metal binding site [ion binding]; metal-binding site
342451007031	stage V sporulation protein B; Region: spore_V_B; TIGR02900
342451007032	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
342451007033	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
342451007034	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
342451007035	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342451007036	ATP binding site [chemical binding]; other site
342451007037	putative Mg++ binding site [ion binding]; other site
342451007038	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342451007039	nucleotide binding region [chemical binding]; other site
342451007040	ATP-binding site [chemical binding]; other site
342451007041	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
342451007042	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
342451007043	putative active site [active]
342451007044	catalytic residue [active]
342451007045	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
342451007046	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
342451007047	5S rRNA interface [nucleotide binding]; other site
342451007048	CTC domain interface [polypeptide binding]; other site
342451007049	L16 interface [polypeptide binding]; other site
342451007050	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
342451007051	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
342451007052	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451007053	active site
342451007054	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
342451007055	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
342451007056	Substrate binding site; other site
342451007057	Mg++ binding site; other site
342451007058	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
342451007059	active site
342451007060	substrate binding site [chemical binding]; other site
342451007061	CoA binding site [chemical binding]; other site
342451007062	regulatory protein SpoVG; Reviewed; Region: PRK13259
342451007063	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
342451007064	homotrimer interaction site [polypeptide binding]; other site
342451007065	putative active site [active]
342451007066	pur operon repressor; Provisional; Region: PRK09213
342451007067	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
342451007068	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451007069	active site
342451007070	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
342451007071	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
342451007072	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
342451007073	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
342451007074	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
342451007075	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
342451007076	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
342451007077	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
342451007078	putative active site [active]
342451007079	putative metal binding site [ion binding]; other site
342451007080	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
342451007081	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
342451007082	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
342451007083	active site
342451007084	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
342451007085	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
342451007086	active site
342451007087	HIGH motif; other site
342451007088	KMSKS motif; other site
342451007089	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
342451007090	tRNA binding surface [nucleotide binding]; other site
342451007091	anticodon binding site; other site
342451007092	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
342451007093	dimer interface [polypeptide binding]; other site
342451007094	putative tRNA-binding site [nucleotide binding]; other site
342451007095	Predicted methyltransferases [General function prediction only]; Region: COG0313
342451007096	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
342451007097	putative SAM binding site [chemical binding]; other site
342451007098	putative homodimer interface [polypeptide binding]; other site
342451007099	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
342451007100	GIY-YIG motif/motif A; other site
342451007101	putative active site [active]
342451007102	putative metal binding site [ion binding]; other site
342451007103	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
342451007104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451007105	S-adenosylmethionine binding site [chemical binding]; other site
342451007106	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
342451007107	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
342451007108	DNA polymerase III subunit delta'; Validated; Region: PRK08058
342451007109	DNA polymerase III subunit delta'; Validated; Region: PRK08485
342451007110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
342451007111	thymidylate kinase; Validated; Region: tmk; PRK00698
342451007112	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
342451007113	TMP-binding site; other site
342451007114	ATP-binding site [chemical binding]; other site
342451007115	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
342451007116	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342451007117	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342451007118	catalytic residue [active]
342451007119	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
342451007120	recombination protein RecR; Reviewed; Region: recR; PRK00076
342451007121	RecR protein; Region: RecR; pfam02132
342451007122	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
342451007123	putative active site [active]
342451007124	putative metal-binding site [ion binding]; other site
342451007125	tetramer interface [polypeptide binding]; other site
342451007126	hypothetical protein; Validated; Region: PRK00153
342451007127	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
342451007128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
342451007129	Walker A motif; other site
342451007130	ATP binding site [chemical binding]; other site
342451007131	Walker B motif; other site
342451007132	arginine finger; other site
342451007133	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
342451007134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451007135	Coenzyme A binding pocket [chemical binding]; other site
342451007136	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
342451007137	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342451007138	DNA-binding site [nucleotide binding]; DNA binding site
342451007139	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
342451007140	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
342451007141	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
342451007142	Ca binding site [ion binding]; other site
342451007143	active site
342451007144	catalytic site [active]
342451007145	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
342451007146	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
342451007147	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
342451007148	active site turn [active]
342451007149	phosphorylation site [posttranslational modification]
342451007150	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
342451007151	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
342451007152	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
342451007153	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
342451007154	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
342451007155	active site
342451007156	dimer interface [polypeptide binding]; other site
342451007157	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
342451007158	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
342451007159	active site
342451007160	FMN binding site [chemical binding]; other site
342451007161	substrate binding site [chemical binding]; other site
342451007162	3Fe-4S cluster binding site [ion binding]; other site
342451007163	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
342451007164	domain interface; other site
342451007165	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451007166	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451007167	LysR substrate binding domain; Region: LysR_substrate; pfam03466
342451007168	dimerization interface [polypeptide binding]; other site
342451007169	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
342451007170	YibE/F-like protein; Region: YibE_F; cl02259
342451007171	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
342451007172	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
342451007173	nudix motif; other site
342451007174	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
342451007175	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
342451007176	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451007177	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451007178	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451007179	Surface antigen [General function prediction only]; Region: COG3942
342451007180	CHAP domain; Region: CHAP; pfam05257
342451007181	N-acetyltransferase; Region: Acetyltransf_2; cl00949
342451007182	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
342451007183	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
342451007184	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
342451007185	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
342451007186	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
342451007187	Na2 binding site [ion binding]; other site
342451007188	putative substrate binding site 1 [chemical binding]; other site
342451007189	Na binding site 1 [ion binding]; other site
342451007190	putative substrate binding site 2 [chemical binding]; other site
342451007191	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
342451007192	Uncharacterized conserved protein [Function unknown]; Region: COG5646
342451007193	Esterase/lipase [General function prediction only]; Region: COG1647
342451007194	Protein of unknown function (DUF867); Region: DUF867; pfam05908
342451007195	cyanate transporter; Region: CynX; TIGR00896
342451007196	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451007197	putative substrate translocation pore; other site
342451007198	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
342451007199	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451007200	putative substrate translocation pore; other site
342451007201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451007202	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451007203	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
342451007204	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451007205	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451007206	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
342451007207	dimerization interface [polypeptide binding]; other site
342451007208	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
342451007209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451007210	putative substrate translocation pore; other site
342451007211	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
342451007212	DNA-binding site [nucleotide binding]; DNA binding site
342451007213	RNA-binding motif; other site
342451007214	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
342451007215	dimer interface [polypeptide binding]; other site
342451007216	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
342451007217	active site
342451007218	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
342451007219	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
342451007220	GMP synthase; Reviewed; Region: guaA; PRK00074
342451007221	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
342451007222	AMP/PPi binding site [chemical binding]; other site
342451007223	candidate oxyanion hole; other site
342451007224	catalytic triad [active]
342451007225	potential glutamine specificity residues [chemical binding]; other site
342451007226	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
342451007227	ATP Binding subdomain [chemical binding]; other site
342451007228	Ligand Binding sites [chemical binding]; other site
342451007229	Dimerization subdomain; other site
342451007230	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
342451007231	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
342451007232	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
342451007233	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
342451007234	active site
342451007235	xanthine permease; Region: pbuX; TIGR03173
342451007236	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
342451007237	active site
342451007238	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
342451007239	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
342451007240	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
342451007241	dimer interface [polypeptide binding]; other site
342451007242	FMN binding site [chemical binding]; other site
342451007243	NADPH bind site [chemical binding]; other site
342451007244	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
342451007245	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451007246	non-specific DNA binding site [nucleotide binding]; other site
342451007247	salt bridge; other site
342451007248	sequence-specific DNA binding site [nucleotide binding]; other site
342451007249	peroxiredoxin; Region: AhpC; TIGR03137
342451007250	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
342451007251	dimer interface [polypeptide binding]; other site
342451007252	decamer (pentamer of dimers) interface [polypeptide binding]; other site
342451007253	catalytic triad [active]
342451007254	peroxidatic and resolving cysteines [active]
342451007255	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
342451007256	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
342451007257	catalytic residue [active]
342451007258	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
342451007259	catalytic residues [active]
342451007260	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
342451007261	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451007262	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
342451007263	catalytic core [active]
342451007264	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
342451007265	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
342451007266	LysE type translocator; Region: LysE; cl00565
342451007267	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
342451007268	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
342451007269	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
342451007270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342451007271	Coenzyme A binding pocket [chemical binding]; other site
342451007272	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
342451007273	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451007274	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
342451007275	Predicted transcriptional regulator [Transcription]; Region: COG1959
342451007276	Transcriptional regulator; Region: Rrf2; pfam02082
342451007277	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
342451007278	putative hydrophobic ligand binding site [chemical binding]; other site
342451007279	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
342451007280	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
342451007281	Protein of unknown function (DUF867); Region: DUF867; pfam05908
342451007282	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
342451007283	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
342451007284	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
342451007285	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
342451007286	putative DNA binding site [nucleotide binding]; other site
342451007287	putative Zn2+ binding site [ion binding]; other site
342451007288	AsnC family; Region: AsnC_trans_reg; pfam01037
342451007289	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
342451007290	amidase catalytic site [active]
342451007291	Zn binding residues [ion binding]; other site
342451007292	substrate binding site [chemical binding]; other site
342451007293	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451007294	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451007295	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
342451007296	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
342451007297	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
342451007298	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
342451007299	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
342451007300	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
342451007301	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
342451007302	dimer interface [polypeptide binding]; other site
342451007303	ssDNA binding site [nucleotide binding]; other site
342451007304	tetramer (dimer of dimers) interface [polypeptide binding]; other site
342451007305	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
342451007306	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
342451007307	active site
342451007308	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
342451007309	GTP-binding protein YchF; Reviewed; Region: PRK09601
342451007310	YchF GTPase; Region: YchF; cd01900
342451007311	G1 box; other site
342451007312	GTP/Mg2+ binding site [chemical binding]; other site
342451007313	Switch I region; other site
342451007314	G2 box; other site
342451007315	Switch II region; other site
342451007316	G3 box; other site
342451007317	G4 box; other site
342451007318	G5 box; other site
342451007319	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
342451007320	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
342451007321	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
342451007322	Mechanosensitive ion channel; Region: MS_channel; pfam00924
342451007323	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
342451007324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
342451007325	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
342451007326	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
342451007327	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
342451007328	Uncharacterized conserved protein [Function unknown]; Region: COG2966
342451007329	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
342451007330	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
342451007331	arsenical pump membrane protein; Provisional; Region: PRK15445
342451007332	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
342451007333	transmembrane helices; other site
342451007334	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
342451007335	dimerization interface [polypeptide binding]; other site
342451007336	putative DNA binding site [nucleotide binding]; other site
342451007337	putative Zn2+ binding site [ion binding]; other site
342451007338	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
342451007339	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451007340	non-specific DNA binding site [nucleotide binding]; other site
342451007341	salt bridge; other site
342451007342	sequence-specific DNA binding site [nucleotide binding]; other site
342451007343	Protein of unknown function (DUF805); Region: DUF805; pfam05656
342451007344	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
342451007345	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
342451007346	acyl-activating enzyme (AAE) consensus motif; other site
342451007347	AMP binding site [chemical binding]; other site
342451007348	active site
342451007349	CoA binding site [chemical binding]; other site
342451007350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451007351	Major Facilitator Superfamily; Region: MFS_1; pfam07690
342451007352	putative substrate translocation pore; other site
342451007353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451007354	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
342451007355	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
342451007356	formate dehydrogenase; Provisional; Region: PRK07574
342451007357	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
342451007358	NAD binding site [chemical binding]; other site
342451007359	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
342451007360	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
342451007361	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
342451007362	active site
342451007363	Methyltransferase domain; Region: Methyltransf_31; pfam13847
342451007364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451007365	S-adenosylmethionine binding site [chemical binding]; other site
342451007366	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
342451007367	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
342451007368	active site
342451007369	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
342451007370	ligand-binding site [chemical binding]; other site
342451007371	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
342451007372	ATP-sulfurylase; Region: ATPS; cd00517
342451007373	active site
342451007374	HXXH motif; other site
342451007375	flexible loop; other site
342451007376	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
342451007377	Rifin/stevor family; Region: Rifin_STEVOR; cl14106
342451007378	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
342451007379	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
342451007380	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
342451007381	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
342451007382	putative active site [active]
342451007383	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
342451007384	putative active site [active]
342451007385	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
342451007386	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
342451007387	active site
342451007388	SAM binding site [chemical binding]; other site
342451007389	homodimer interface [polypeptide binding]; other site
342451007390	sulfite reductase subunit beta; Provisional; Region: PRK13504
342451007391	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
342451007392	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
342451007393	Protein of unknown function (DUF1636); Region: DUF1636; cl17843
342451007394	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
342451007395	Flavodoxin; Region: Flavodoxin_1; pfam00258
342451007396	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
342451007397	FAD binding pocket [chemical binding]; other site
342451007398	FAD binding motif [chemical binding]; other site
342451007399	catalytic residues [active]
342451007400	NAD binding pocket [chemical binding]; other site
342451007401	phosphate binding motif [ion binding]; other site
342451007402	beta-alpha-beta structure motif; other site
342451007403	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
342451007404	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
342451007405	Active Sites [active]
342451007406	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
342451007407	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
342451007408	heme-binding site [chemical binding]; other site
342451007409	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
342451007410	FAD binding pocket [chemical binding]; other site
342451007411	FAD binding motif [chemical binding]; other site
342451007412	phosphate binding motif [ion binding]; other site
342451007413	beta-alpha-beta structure motif; other site
342451007414	NAD binding pocket [chemical binding]; other site
342451007415	Heme binding  pocket [chemical binding]; other site
342451007416	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
342451007417	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
342451007418	ParB-like nuclease domain; Region: ParB; smart00470
342451007419	cystathionine gamma-synthase; Reviewed; Region: PRK08247
342451007420	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342451007421	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342451007422	catalytic residue [active]
342451007423	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
342451007424	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
342451007425	homodimer interface [polypeptide binding]; other site
342451007426	substrate-cofactor binding pocket; other site
342451007427	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342451007428	catalytic residue [active]
342451007429	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
342451007430	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
342451007431	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
342451007432	FAD binding site [chemical binding]; other site
342451007433	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
342451007434	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
342451007435	THF binding site; other site
342451007436	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
342451007437	substrate binding site [chemical binding]; other site
342451007438	THF binding site; other site
342451007439	zinc-binding site [ion binding]; other site
342451007440	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
342451007441	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
342451007442	Flavodoxin; Region: Flavodoxin_1; pfam00258
342451007443	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
342451007444	FAD binding pocket [chemical binding]; other site
342451007445	FAD binding motif [chemical binding]; other site
342451007446	catalytic residues [active]
342451007447	NAD binding pocket [chemical binding]; other site
342451007448	phosphate binding motif [ion binding]; other site
342451007449	beta-alpha-beta structure motif; other site
342451007450	VPS10 domain; Region: VPS10; smart00602
342451007451	LytTr DNA-binding domain; Region: LytTR; smart00850
342451007452	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
342451007453	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
342451007454	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
342451007455	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
342451007456	dimer interface [polypeptide binding]; other site
342451007457	active site
342451007458	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
342451007459	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
342451007460	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
342451007461	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
342451007462	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
342451007463	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
342451007464	substrate binding site [chemical binding]; other site
342451007465	oxyanion hole (OAH) forming residues; other site
342451007466	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
342451007467	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
342451007468	active site
342451007469	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
342451007470	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
342451007471	acyl-activating enzyme (AAE) consensus motif; other site
342451007472	AMP binding site [chemical binding]; other site
342451007473	active site
342451007474	CoA binding site [chemical binding]; other site
342451007475	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
342451007476	Coenzyme A transferase; Region: CoA_trans; smart00882
342451007477	Coenzyme A transferase; Region: CoA_trans; cl17247
342451007478	BCCT family transporter; Region: BCCT; cl00569
342451007479	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
342451007480	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451007481	amino acid transporter; Region: 2A0306; TIGR00909
342451007482	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
342451007483	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342451007484	active site
342451007485	catalytic tetrad [active]
342451007486	FeoA domain; Region: FeoA; pfam04023
342451007487	RES domain; Region: RES; smart00953
342451007488	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
342451007489	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
342451007490	DNA binding residues [nucleotide binding]
342451007491	dimer interface [polypeptide binding]; other site
342451007492	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
342451007493	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
342451007494	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342451007495	non-specific DNA binding site [nucleotide binding]; other site
342451007496	salt bridge; other site
342451007497	sequence-specific DNA binding site [nucleotide binding]; other site
342451007498	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
342451007499	Carbon starvation protein CstA; Region: CstA; pfam02554
342451007500	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
342451007501	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
342451007502	ParB-like nuclease domain; Region: ParBc; pfam02195
342451007503	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
342451007504	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
342451007505	S-adenosylmethionine binding site [chemical binding]; other site
342451007506	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
342451007507	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
342451007508	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
342451007509	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
342451007510	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
342451007511	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
342451007512	trmE is a tRNA modification GTPase; Region: trmE; cd04164
342451007513	G1 box; other site
342451007514	GTP/Mg2+ binding site [chemical binding]; other site
342451007515	Switch I region; other site
342451007516	G2 box; other site
342451007517	Switch II region; other site
342451007518	G3 box; other site
342451007519	G4 box; other site
342451007520	G5 box; other site
342451007521	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
342451007522	ribonuclease P; Reviewed; Region: rnpA; PRK00499
342451007523	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
342451007524	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
342451007525	phosphate binding site [ion binding]; other site
342451007526	MarR family; Region: MarR_2; pfam12802
342451007527	Predicted membrane protein [Function unknown]; Region: COG1511
342451007528	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
342451007529	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
342451007530	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
342451007531	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
342451007532	CHAP domain; Region: CHAP; pfam05257
342451007533	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
342451007534	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
342451007535	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
342451007536	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342451007537	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
342451007538	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
342451007539	putative dimerization interface [polypeptide binding]; other site
342451007540	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
342451007541	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
342451007542	catalytic residues [active]
342451007543	catalytic nucleophile [active]
342451007544	Presynaptic Site I dimer interface [polypeptide binding]; other site
342451007545	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
342451007546	Synaptic Flat tetramer interface [polypeptide binding]; other site
342451007547	Synaptic Site I dimer interface [polypeptide binding]; other site
342451007548	DNA binding site [nucleotide binding]
342451007549	HTH domain; Region: HTH_11; cl17392
342451007550	Low molecular weight phosphatase family; Region: LMWPc; cd00115
342451007551	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
342451007552	active site
342451007553	arsenical pump membrane protein; Provisional; Region: PRK15445
342451007554	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
342451007555	transmembrane helices; other site
342451007556	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
342451007557	dimerization interface [polypeptide binding]; other site
342451007558	putative DNA binding site [nucleotide binding]; other site
342451007559	putative Zn2+ binding site [ion binding]; other site
342451007560	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
342451007561	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
342451007562	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
342451007563	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
342451007564	active site residue [active]
342451007565	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
342451007566	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
342451007567	P loop; other site
342451007568	Nucleotide binding site [chemical binding]; other site
342451007569	DTAP/Switch II; other site
342451007570	Switch I; other site
342451007571	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
342451007572	P loop; other site
342451007573	Nucleotide binding site [chemical binding]; other site
342451007574	DTAP/Switch II; other site
342451007575	Switch I; other site
342451007576	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
342451007577	hypothetical protein; Provisional; Region: PRK00955
342451007578	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
342451007579	dimerization interface [polypeptide binding]; other site
342451007580	putative DNA binding site [nucleotide binding]; other site
342451007581	putative Zn2+ binding site [ion binding]; other site
342451007582	Predicted permeases [General function prediction only]; Region: COG0701
342451007583	Predicted transcriptional regulator [Transcription]; Region: COG3905
342451007584	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
342451007585	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
342451007586	P-loop; other site
342451007587	Magnesium ion binding site [ion binding]; other site
342451007588	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
342451007589	Magnesium ion binding site [ion binding]; other site
342451007590	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
342451007591	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
342451007592	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
342451007593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
342451007594	Integrase core domain; Region: rve; pfam00665
342451007595	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
342451007596	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
342451007597	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
342451007598	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
342451007599	ATP binding site [chemical binding]; other site
342451007600	substrate interface [chemical binding]; other site
342451007601	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
342451007602	ThiS interaction site; other site
342451007603	putative active site [active]
342451007604	tetramer interface [polypeptide binding]; other site
342451007605	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
342451007606	thiS-thiF/thiG interaction site; other site
342451007607	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
342451007608	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
342451007609	thiamine phosphate binding site [chemical binding]; other site
342451007610	active site
342451007611	pyrophosphate binding site [ion binding]; other site
342451007612	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
342451007613	N- and C-terminal domain interface [polypeptide binding]; other site
342451007614	D-xylulose kinase; Region: XylB; TIGR01312
342451007615	active site
342451007616	MgATP binding site [chemical binding]; other site
342451007617	catalytic site [active]
342451007618	metal binding site [ion binding]; metal-binding site
342451007619	xylulose binding site [chemical binding]; other site
342451007620	homodimer interface [polypeptide binding]; other site
342451007621	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
342451007622	Integrase core domain; Region: rve; pfam00665
342451007623	Replication protein; Region: Rep_1; cl02412
342451007624	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
342451007625	amphipathic channel; other site
342451007626	Asn-Pro-Ala signature motifs; other site
342451007627	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
342451007628	Integrase core domain; Region: rve; pfam00665
342451007629	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342451007630	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342451007631	LysE type translocator; Region: LysE; cl00565
342451007632	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
342451007633	Replication protein; Region: Rep_1; cl02412
342451007634	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
342451007635	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
342451007636	active site
342451007637	motif I; other site
342451007638	motif II; other site
342451007639	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
342451007640	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
342451007641	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
342451007642	conserved cys residue [active]
342451007643	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
342451007644	DNA-binding site [nucleotide binding]; DNA binding site
342451007645	RNA-binding motif; other site
342451007646	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
342451007647	Integrase core domain; Region: rve; pfam00665
342451007648	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
342451007649	Integrase core domain; Region: rve; pfam00665
342451007650	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
342451007651	amphipathic channel; other site
342451007652	Asn-Pro-Ala signature motifs; other site
342451007653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
342451007654	Integrase core domain; Region: rve; pfam00665
342451007655	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
342451007656	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
342451007657	catalytic residues [active]
342451007658	catalytic nucleophile [active]
342451007659	cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779
342451007660	Cadmium resistance transporter; Region: Cad; pfam03596
342451007661	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
342451007662	metal-binding site [ion binding]
342451007663	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
342451007664	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
342451007665	metal-binding site [ion binding]
342451007666	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
342451007667	Soluble P-type ATPase [General function prediction only]; Region: COG4087
342451007668	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
342451007669	dimerization interface [polypeptide binding]; other site
342451007670	putative DNA binding site [nucleotide binding]; other site
342451007671	putative Zn2+ binding site [ion binding]; other site
342451007672	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
342451007673	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
342451007674	Predicted transcriptional regulators [Transcription]; Region: COG1695
342451007675	Transcriptional regulator PadR-like family; Region: PadR; cl17335
342451007676	MMPL family; Region: MMPL; pfam03176
342451007677	MMPL family; Region: MMPL; pfam03176
342451007678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342451007679	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
342451007680	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891